leonurus

Summary

Summary: A plant genus of the family LAMIACEAE that contains leonurine.

Top Publications

  1. Ahmed F, Islam M, Rahman M. Antibacterial activity of Leonurus sibiricus aerial parts. Fitoterapia. 2006;77:316-7 pubmed
    Different solvent extracts (carbon tetrachloride, chloroform, acetone and methanol) of Leonurus sibiricus were studied for their antibacterial activity...
  2. Islam M, Ahmed F, Das A, Bachar S. Analgesic and anti-inflammatory activity of Leonurus sibiricus. Fitoterapia. 2005;76:359-62 pubmed
    The methanolic extract of Leonurus sibiricus aerial parts injected intraperitoneally at dose of 250 and 500 mg/kg showed a significant analgesic effect in acetic acid-induced writhing in mice...
  3. Ojewole J. Antinociceptive, antiinflammatory and antidiabetic effects of Leonotis leonurus (L.) R. BR. [Lamiaceae] leaf aqueous extract in mice and rats. Methods Find Exp Clin Pharmacol. 2005;27:257-64 pubmed
    ..the antinociceptive, antiinflammatory, and antidiabetic properties of the aqueous leaf extract of Leonotis leonurus (L.) R. BR...
  4. Yang X, Li J, Li X, She R, Pei Y. Isolation and characterization of a novel thermostable non-specific lipid transfer protein-like antimicrobial protein from motherwort (Leonurus japonicus Houtt) seeds. Peptides. 2006;27:3122-8 pubmed
    ..seeds, a novel heat-stable antimicrobial protein, designated LJAMP2, was purified from seeds of the motherwort (Leonurus japonicus Houtt), a medicine herb, with a procedure involving cation exchange chromatography on a CM FF column, ..
  5. Yang X, Xiao Y, Wang X, Pei Y. Expression of a novel small antimicrobial protein from the seeds of motherwort (Leonurus japonicus) confers disease resistance in tobacco. Appl Environ Microbiol. 2007;73:939-46 pubmed
    ..with antimicrobial activities, designated LJAMP1, was purified from the seeds of a medicinal herb, motherwort (Leonurus japonicus Houtt). LJAMP1 is a heat-stable protein with a molecular mass of 7...
  6. Yu J, Wang J, Zhao R, Bao Z, Cai S. [Advances in studies of renal adverse reactions of Leonurus heterophyllus]. Zhongguo Zhong Yao Za Zhi. 2010;35:1213-6 pubmed
    Motherwort (Herb of Leonurus heterophyllus) was a traditional Chinese medicine used for the treatment of various kinds of gynaecological diseases, which was considered as non-toxic medicine since ancient times...
  7. Jia Z, Gou J, Sun Y, Yuan L, Tang Q, Yang X, et al. Enhanced resistance to fungal pathogens in transgenic Populus tomentosa Carr. by overexpression of an nsLTP-like antimicrobial protein gene from motherwort (Leonurus japonicus). Tree Physiol. 2010;30:1599-605 pubmed publisher
    The antimicrobial protein gene LJAMP2 is a plant non-specific lipid transfer protein from motherwort (Leonurus japonicus). In this study, it was introduced into Chinese white poplar (Populus tomentosa Carr...
  8. Liang H, Liu P, Wang Y, Song S, Ji A. Protective effects of alkaloid extract from Leonurus heterophyllus on cerebral ischemia reperfusion injury by middle cerebral ischemic injury (MCAO) in rats. Phytomedicine. 2011;18:811-8 pubmed publisher
    ..The aim of this study was to investigate the neuroprotective effects of alkaloid extract from Leonurus heterophyllus (LHAE) on cerebral ischemic injury...
  9. Pitschmann A, Waschulin C, Sykora C, Purevsuren S, Glasl S. Microscopic and Phytochemical Comparison of the Three Leonurus Species L. cardiaca, L. japonicus, and L. sibiricus. Planta Med. 2017;83:1233-1241 pubmed publisher
    At least three Leonurus species, Leonurus cardiaca, Leonurus japonicus, and Leonurus sibiricus, are used in various traditional medicinal systems for different therapeutic purposes. The plant names "L...

More Information

Publications106 found, 100 shown here

  1. Shi X, Hong Z, Liu H, Zhang Y, Zhu Y. Neuroprotective effects of SCM198 on 6-hydroxydopamine-induced behavioral deficit in rats and cytotoxicity in neuronal SH-SY5Y cells. Neurochem Int. 2011;58:851-60 pubmed publisher
    ..Therefore we suggest that SCM198 might provide a useful therapeutic strategy for neurodegenerative diseases such as Parkinson's disease. ..
  2. Nsuala B, Enslin G, Viljoen A. "Wild cannabis": A review of the traditional use and phytochemistry of Leonotis leonurus. J Ethnopharmacol. 2015;174:520-39 pubmed publisher
    Leonotis leonurus, locally commonly known as "wilde dagga" (=wild cannabis), is traditionally used as a decoction, both topically and orally, in the treatment of a wide variety of conditions such as haemorrhoids, eczema, skin rashes, ..
  3. Wu H, Sun T, Zhao F, Zhang L, Li G, Zhang J. New diterpenoids isolated from Leonurus japonicus and their acetylcholinesterase inhibitory activity. Chin J Nat Med. 2017;15:860-864 pubmed publisher
    ..leojaponicone A (1), isoleojaponicone A (2) and methylisoleojaponicone A (3), were isolated from the herb of Leonurus japonicus...
  4. Zheng X, Lv P, Wang L, Feng W, Wang J, Niu J. [Experimental study of estrogenic activities of five kinds of Chinese herbal medicines]. Zhongguo Zhong Yao Za Zhi. 2006;31:1254-7 pubmed
    ..To evaluate the estrogenic activity of several kinds of Chinese herbal medicines...
  5. Saeed M, Meyer M, Hussein A, Efferth T. Cytotoxicity of South-African medicinal plants towards sensitive and multidrug-resistant cancer cells. J Ethnopharmacol. 2016;186:209-223 pubmed publisher
    ..Seven extracts inhibited both cell lines (Acokanthera oppositifolia, Hypoestes aristata, Laurus nobilis, Leonotis leonurus, Plectranthus barbatus, Plectranthus ciliates, Salvia apiana)...
  6. Li B, Wu J, Li X. Simultaneous determination and pharmacokinetic study of stachydrine and leonurine in rat plasma after oral administration of Herba Leonuri extract by LC-MS/MS. J Pharm Biomed Anal. 2013;76:192-9 pubmed publisher
    ..75±0.27 and 0.83±0.26h. The results demonstrated that the present LC-MS/MS method was sensitive enough for pharmacokinetic study of stachydrine and leonurine following oral administration of Herba Leonuri extract. ..
  7. Zhang X, Zhang Z. Heart-cut two-dimensional separation method via hyphenation of micellar electrokinetic capillary chromatography and capillary zone electrophoresis using analyte focusing by micelle collapse. J Chromatogr B Analyt Technol Biomed Life Sci. 2011;879:1641-6 pubmed publisher
    ..chromatography (MEKC) and capillary zone electrophoresis (CZE), was developed for analysis of flavonoids in Leonurus cardiaca. The Leonurus cardiaca sample was separated and purified in first dimension by MEKC...
  8. Oliveira A, Cercato L, de Santana Souza M, Melo A, Lima B, Duarte M, et al. The ethanol extract of Leonurus sibiricus L. induces antioxidant, antinociceptive and topical anti-inflammatory effects. J Ethnopharmacol. 2017;206:144-151 pubmed publisher
    b>Leonurus sibiricus L...
  9. Xiao C, Liu Y, Luo S, Hua J, Liu Y, Li S. Localisation of Two Bioactive Labdane Diterpenoids in the Peltate Glandular Trichomes of Leonurus japonicus by Laser Microdissection Coupled with UPLC-MS/MS. Phytochem Anal. 2017;28:404-409 pubmed publisher
    ..The Labiatae plant Leonurus japonicus is an important traditional Chinese medicine used to treat gynecological diseases, and has abundant ..
  10. Zhao L, Wu D, Sang M, Xu Y, Liu Z, Wu Q. Stachydrine ameliorates isoproterenol-induced cardiac hypertrophy and fibrosis by suppressing inflammation and oxidative stress through inhibiting NF-κB and JAK/STAT signaling pathways in rats. Int Immunopharmacol. 2017;48:102-109 pubmed publisher
    ..Stachydrine (STA), which is isolated from Leonurus, has various activities, including resistance to cardiovascular disease, but little is known about its effect on ..
  11. Mamadalieva N, Akramov D, Ovidi E, Tiezzi A, Nahar L, Azimova S, et al. Aromatic Medicinal Plants of the Lamiaceae Family from Uzbekistan: Ethnopharmacology, Essential Oils Composition, and Biological Activities. Medicines (Basel). 2017;4: pubmed publisher
    ..Various species of the genera Hyssopus, Leonurus, Mentha, Nepeta, Origanum, Perovskia, Phlomis, Salvia, ..
  12. Lee M, Park K, Ma J. Leonurus japonicus Houtt Attenuates Nonalcoholic Fatty Liver Disease in Free Fatty Acid-Induced HepG2 Cells and Mice Fed a High-Fat Diet. Nutrients. 2017;10: pubmed publisher
    We investigated the effects of a Leonurus japonicus ethanol extract (LJE) on nonalcoholic fatty liver disease (NAFLD). An in vitro model of hepatic steatosis was treated with 1 mM free fatty acid (FFA) in HepG2 cells...
  13. Wu H, Fronczek F, Ferreira D, Burandt C, Zjawiony J. Labdane diterpenoids from Leonurus sibiricus. J Nat Prod. 2011;74:831-6 pubmed publisher
    ..A (3), leosibirone A (4), leosibirone B (5), and 15-epi-leosibirone B (6), were isolated from the leaves of Leonurus sibiricus...
  14. Yang Z, Pan S, Huo K, Wu B, Chao Z. Molecular analysis of Leonurus species in China based on ITS and matK sequences. Am J Chin Med. 2011;39:411-22 pubmed
    The genus Leonurus has long been recognized as a natural group, but its interspecific relationship has not yet been studied in the light of sequence data...
  15. Leem H, Lee G, Lee J, Lee H, Kim J, Kim Y. Soluble epoxide hydrolase inhibitory activity of components from Leonurus japonicus. Int J Biol Macromol. 2017;103:451-457 pubmed publisher
    ..and four known compounds (2-5) were purified by silica gel, C-18, and Sephadex LH-20 column chromatography from Leonurus japonicus...
  16. Ritter M, Melichar K, Strahler S, Kuchta K, Schulte J, Sartiani L, et al. Cardiac and electrophysiological effects of primary and refined extracts from Leonurus cardiaca L. (Ph.Eur.). Planta Med. 2010;76:572-82 pubmed publisher
    ..On the other hand, aqueous extracts from the aerial parts of the European Lamiaceae Leonurus cardiaca (Ph.Eur.) have been used for centuries as a remedy against tachyarrhythmia and other cardiac disorders...
  17. Chen S, Wang A, Lin L, Qiu H, Wang Y, Wang Y. In Vitro Study on Anti-Hepatitis C Virus Activity of Spatholobus suberectus Dunn. Molecules. 2016;21: pubmed
    ..flower), Crataegus pinnatifida Bge. (fruit), and Leonurus japonicas Houtt. (leaf) extracts failed to show a similar activity. Active S...
  18. Chen Z, Wu J, Liao X, Yang W, Song K. Development and validation of an UPLC-DAD-MS method for the determination of leonurine in Chinese motherwort (Leonurus japonicus). J Chromatogr Sci. 2010;48:802-6 pubmed
    ..diode array detection (UPLC-DAD) was developed for the analysis and determination of leonurine from motherwort (Leonurus japonicus), a traditional Chinese medicinal plant...
  19. Zhang C, Gu Y, Yuan B, Liu Y, Guo W, Wei H, et al. [Protective effects of Leonurus japonicas on myocardial remodeling induced by isoproterenol in rats]. Zhong Yao Cai. 2011;34:1399-402 pubmed
    To investigate the effects of Leonurus japonicas on myocardial remodeling induced by isoproterenol (ISO) in rats...
  20. Zhang K, Zeng X, Chen Y, Zhao R, Wang H, Wu J. Therapeutic effects of Qian-Yu decoction and its three extracts on carrageenan-induced chronic prostatitis/chronic pelvic pain syndrome in rats. BMC Complement Altern Med. 2017;17:75 pubmed publisher
    ..K. Hsiao, Fabaceae ), Herba epimedii (Epimedium brevicornum Maxim., Berberidaceae), Herba leonuri (Leonurus japonicus Houtt., Lamiaceae), Cortex phellodendri (Phellodendron chinense Schneid...
  21. Guo W, Zhang C, Liao Y, Lv R, Wei H. [Effect of Leonurus stachydrine on myocardial cell hypertrophy]. Zhong Yao Cai. 2012;35:940-3 pubmed
    To investigate the effects of Leonurus stachydrine on myocardial cell hypertrophy induced by angiotensin II in rats...
  22. Yang M, Yang S, Jin Z, Zhu S. [Study on the biological assay of Herba Leonuri--analysis the dosage response curve of Herba Leonuri and oxytocin and establishment of adequate potency pattern]. Zhong Yao Cai. 2002;25:409-11 pubmed
    ..The result error of Herba Leonuri assay is under 20%, not exceed the demand limits of biological assay. ..
  23. Ye M, Xiong J, Zhu J, Hong J, Zhao Y, Fan H, et al. Leonurusoleanolides E-J, minor spirocyclic triterpenoids from Leonurus japonicus fruits. J Nat Prod. 2014;77:178-82 pubmed publisher
    ..E-J, 1-6) and five known (7-11) nortriterpenoids were isolated and characterized from the dried fruits of Leonurus japonicus...
  24. Ovanesov K. [The effect of tofisopam and tinctura leonuri on the color-discrimination function in young humans]. Eksp Klin Farmakol. 2005;68:56-9 pubmed
    ..It is suggested that this improvement is related to the drug action upon the GABAergic processes both in the retina and in the related cerebral structures. ..
  25. Tao J, Zhang P, Liu G, Yan H, Bu X, Ma Z, et al. Cytotoxicity of Chinese motherwort (YiMuCao) aqueous ethanol extract is non-apoptotic and estrogen receptor independent on human breast cancer cells. J Ethnopharmacol. 2009;122:234-9 pubmed
    ..Aerial part of Chinese motherwort (Leonurus japonicus Houtt) dry powder is extracted with 70% ethanol and the chemical components were characterized with ..
  26. Du Y, Yi Q, Xiong Y, Xu L. [Effect of fluidized bed technology on micromeritics properties of Leonurus Herba extract]. Zhongguo Zhong Yao Za Zhi. 2017;42:2977-2983 pubmed publisher
    Based on different binders, the Leonurus Herba extract powders were fluidized and modified...
  27. Yang M, Yang S, Jin Z, Guo Y. [Study on the biological assay of Herba Leonuri(I)--Establishment of standard uterus models and optimizing uterus environment conditions]. Zhong Yao Cai. 2002;25:333-6 pubmed
    ..06 g and 0.25 g. Under the selected conditions, the contracting uterus effect of Herba Leonuri were more obvious and the errors of bioassay were less smaller. ..
  28. Loh K, Huang S, Tan B, Zhu Y. Cerebral protection of purified Herba Leonuri extract on middle cerebral artery occluded rats. J Ethnopharmacol. 2009;125:337-43 pubmed publisher
    ..pHL could reduce the level of apoptosis and also the pro-apoptotic proteins, but increase the level of anti-apoptotic proteins. pHL is believed to have promising therapeutic effect for stroke treatment through antioxidant mechanisms. ..
  29. Lee M, Lee H, Park S, Moon H, Park W. Leonurus sibiricus herb extract suppresses oxidative stress and ameliorates hypercholesterolemia in C57BL/6 mice and TNF-alpha induced expression of adhesion molecules and lectin-like oxidized LDL receptor-1 in human umbilical vein endothelial cells. Biosci Biotechnol Biochem. 2010;74:279-84 pubmed
    In Leonurus sibiricus herb extract (LHE)-supplemented animals, plasma cholesterol decreased and high-density lipoprotein-cholesterol increased, resulting in a lowered atherogenic index...
  30. Chen H, Zhao P, Zhao W, Tian J, Guo W, Xu M, et al. Stachydrine ameliorates pressure overload-induced diastolic heart failure by suppressing myocardial fibrosis. Am J Transl Res. 2017;9:4250-4260 pubmed
    Stachydrine (Sta), a major constituent of Leonurus japonicus Houtt, has been reported to possess numerous cardioprotective effects...
  31. Satoh M, Satoh Y, Isobe K, Fujimoto Y. Studies on the constituents of Leonurus sibiricus L. Chem Pharm Bull (Tokyo). 2003;51:341-2 pubmed
    ..and LS-2 (2), were isolated along with four known furanoditerpene-lactones 3, 4, 5 and 6 from the aerial part of Leonurus sibiricus L. The structures of the new compounds were determined by spectroscopic means...
  32. Qi J, Hong Z, Xin H, Zhu Y. Neuroprotective effects of leonurine on ischemia/reperfusion-induced mitochondrial dysfunctions in rat cerebral cortex. Biol Pharm Bull. 2010;33:1958-64 pubmed
    ..The findings of this study suggest that leonurine has promising therapeutic effect for ischemic stroke treatment through antioxidant and anti-apoptotic mechanisms. ..
  33. Huang Y, Liu H, Jia Z, Fang Q, Luo K. Combined expression of antimicrobial genes (Bbchit1 and LJAMP2) in transgenic poplar enhances resistance to fungal pathogens. Tree Physiol. 2012;32:1313-20 pubmed publisher
    ..These results indicated that the combined expression of the LJAMP2 and Bbchit-1 genes could significantly enhance resistance to necrotrophic fungal pathogens in poplar. ..
  34. Cai X, Che C, Lam C, Mak T, Wu L. A new labdane diterpene from Leonurus heterophyllus. J Asian Nat Prod Res. 2006;8:599-603 pubmed
    ..B (1), together with a known labdane diterpene, heteronone A (2), have been isolated from the aerial part of Leonurus heterophyllus...
  35. An H, Rim H, Lee J, Suh S, Lee J, Kim N, et al. Leonurus sibiricus induces nitric oxide and tumor necrosis factor-alpha in mouse peritoneal macrophages. Can J Physiol Pharmacol. 2008;86:682-90 pubmed publisher
    Using mouse peritoneal macrophages, we have examined the mechanism by which Leonurus sibiricus (LS) regulates nitric oxide (NO) production...
  36. Sitarek P, Kowalczyk T, Rijo P, Białas A, Wielanek M, Wysokinska H, et al. Over-Expression of AtPAP1 Transcriptional Factor Enhances Phenolic Acid Production in Transgenic Roots of Leonurus sibiricus L. and Their Biological Activities. Mol Biotechnol. 2018;60:74-82 pubmed publisher
    ..and p-coumaric acid) following over-expression of AtPAP1 transcription factor by four transgenic root clones of Leonurus sibiricus after Agrobacterium rhizogenes transformation...
  37. Liu G. [Advances in pharmacological study of Leonurus heterophyllus Sweet]. Zhong Yao Cai. 2002;25:71-2 pubmed
  38. Chen Z, Song K, Li X, Wang L. [Determination of leonurine in leonurus granule and extractum by UPLC]. Zhongguo Zhong Yao Za Zhi. 2009;34:1509-11 pubmed
    ..The results showed that there was significant difference in the content of leonurine in the leonurus products from different pharmaceutical companies. The leonurine content in those products is in the range of 45...
  39. Han S, Han H, Lee B, Min B, Chung M, Young Jeong J, et al. Toxicity assessment of Leonuri Herba aqueous extract orally administered to rats for 13 consecutive weeks. J Ethnopharmacol. 2013;149:371-6 pubmed publisher
    ..And the acceptable daily intake value for Leonuri Herba aqueous extract was calculated to be 10mg/kg body weight per day using a safety factor of 100 to the NOAEL. ..
  40. Giang P, Son P, Matsunami K, Otsuka H. New labdane-type diterpenoids from Leonurus heterophyllus SW. Chem Pharm Bull (Tokyo). 2005;53:938-41 pubmed
    ..of beta-sitosterol and stigmasterol, and the flavone genkwanin (10) were isolated from the aerial parts of Leonurus heterophyllus SW. (Lamiaceae) collected in northern Vietnam...
  41. Liu J, Peng C, Zhou Q, Guo L, Liu Z, Xiong L. Alkaloids and flavonoid glycosides from the aerial parts of Leonurus japonicus and their opposite effects on uterine smooth muscle. Phytochemistry. 2018;145:128-136 pubmed publisher
    The crude extract and some Chinese patented medicines of Leonurus japonicus Houtt. have been proven to affect the uterine smooth muscle. L...
  42. Bernatoniene J, Kucinskaite A, Masteikova R, Kalveniene Z, Kasparaviciene G, Savickas A. The comparison of anti-oxidative kinetics in vitro of the fluid extract from maidenhair tree, motherwort and hawthorn. Acta Pol Pharm. 2009;66:415-21 pubmed
    ..motherwort (Leonurus cardiaca L.) and hawthorn (Crataegus monogyna Jacq...
  43. Sitarek P, Skała E, Wysokinska H, Wielanek M, Szemraj J, Toma M, et al. The Effect of Leonurus sibiricus Plant Extracts on Stimulating Repair and Protective Activity against Oxidative DNA Damage in CHO Cells and Content of Phenolic Compounds. Oxid Med Cell Longev. 2016;2016:5738193 pubmed publisher
    b>Leonurus sibiricus L. has been used as a traditional and medicinal herb for many years in Asia and Europe...
  44. Ebrahimzadeh M, Nabavi S, Nabavi S. Correlation between the in vitro iron chelating activity and poly phenol and flavonoid contents of some medicinal plants. Pak J Biol Sci. 2009;12:934-8 pubmed
    ..4-194.9 mg g(-1) of extract. The highest chelating activity was found in aerial parts of Leonurus cardiana and Grammosciadium platycarpum which had high amount of phenol and flavonoid contents...
  45. Zheng Y, Yan H, Han J, Tan N. [A new C-28 nortriterpenoid from fruits of Leonurus japonicus]. Zhongguo Zhong Yao Za Zhi. 2012;37:2088-91 pubmed
    To study the chemical constituents from the fruits of Leonurus japonicus.
  46. Ji S, Fattahi A, Raffel N, Hoffmann I, Beckmann M, Dittrich R, et al. Antioxidant effect of aqueous extract of four plants with therapeutic potential on gynecological diseases; Semen persicae, Leonurus cardiaca, Hedyotis diffusa, and Curcuma zedoaria. Eur J Med Res. 2017;22:50 pubmed publisher
    ..The aqueous extracts of Semen persicae, Leonurus cardiaca, Hedyotis diffusa, and Curcuma zedoaria rhizome were prepared and then their effects on copper-induced ..
  47. Luo Y, Luo S, Zhou B. [Chromatographic identification of a compound similar to ferulic acid in the decoction of Herb Leonuri]. Zhong Yao Cai. 2002;25:713-4 pubmed
    ..To identify whether there is ferulic acid in decoction of Herb Leonuri...
  48. Yu D, Xu D, Feng Y, Wei H. [Enriching of total flavonoids from Herba Leonuri with polyamide and macroporous resin]. Zhongguo Zhong Yao Za Zhi. 2008;33:264-8 pubmed
    ..To study the enriching method of total flavonoid from Herba Leonuri with polyamide and macroporous resin...
  49. Moon H, Jin Q, Shin J, Choi E, Han H, Kim Y, et al. Bis-spirolabdane-type diterpenoids from Leonurus sibiricus. J Nat Prod. 2010;73:123-6 pubmed publisher
    ..E (5), and 3alpha-acetoxy-15-epileoheteronone E (6), were isolated from the aerial parts of Leonurus sibiricus...
  50. Gajdziok J, Bernatoniene J, Muselik J, Masteikova R, Dvorácková K, Petkeviciūte Z, et al. The evaluation of formulations for the preparation of new formula pellets. Pharm Dev Technol. 2011;16:520-8 pubmed publisher
    The aim of the study was to prepare pellets of maidenhair tree (Ginkgo biloba), motherwort (Leonurus cardiaca) and hawthorn (Crataegus monogyna) dry extracts by extrusion/spheronization method...
  51. Chang J, Shen C, Huang Y, Shieh B, Chen C. Two new glycosides from Leonurus japonicus. J Asian Nat Prod Res. 2010;12:740-4 pubmed publisher
    ..3-O-[(3-O-syringoyl-?-L-rhamnopyranosyl)-(1?6)-?-D-glucopyranoside] (2), along with seven known compounds were isolated from the MeOH extract of Leonurus japonicus. The structures of these compounds were elucidated by spectral analysis.
  52. Huang H, Xin H, Liu X, Xu Y, Wen D, Zhang Y, et al. Novel anti-diabetic effect of SCM-198 via inhibiting the hepatic NF-?B pathway in db/db mice. Biosci Rep. 2012;32:185-95 pubmed publisher
    ..Consequently, we suggest that SCM-198 may be a prospective agent for prevention and/or moderation of the progress of Type 2 diabetes...
  53. Im A, Han L, Kim E, Kim J, Kim Y, Park Y. Enhanced antibacterial activities of leonuri herba extracts containing silver nanoparticles. Phytother Res. 2012;26:1249-55 pubmed publisher
    ..The process reported here has the potential to be a new approach to improve the antibacterial activities of plant extracts...
  54. Sun Y, Ma Y, Xing X, Xiao X. [Probing into objectivity of adverse drug reaction of traditional Chinese medicine]. Zhongguo Zhong Yao Za Zhi. 2006;31:1381-3 pubmed
    ..The ADR of 6 kinds of typical TCM which state attached importance to was chosen to discuss. Based on the retrospect investigation, the objectivity of ADR was explored in this study...
  55. Chen L, Zhao L, Bai Y, Hu R, Si J. [Genetic relationship analysis of different provenances of Leonurus japonicus by ISSR marker]. Zhongguo Zhong Yao Za Zhi. 2009;34:1343-5 pubmed
    To study the genetic polymorphism and genetic relationship of different provenances of Leonurus japonicus.
  56. Xie C, Zhang B, Wang D, Kou F, Zhao X, Yang X. Molecular cloning and characterization of an achene-seed-specific promoter from motherwort (Leonurus japonicus Houtt). Biotechnol Lett. 2011;33:167-72 pubmed publisher
    ..The analysis of cis-acting elements also revealed pLJAMP1 promoter contained pollen and seed related transcriptional control elements...
  57. Hung T, Luan T, Vinh B, Cuong T, Min B. Labdane-type diterpenoids from Leonurus heterophyllus and their cholinesterase inhibitory activity. Phytother Res. 2011;25:611-4 pubmed publisher
    ..of screening plants used in natural medicines as memory enhancers, a 70% ethanol extract of the aerial parts of Leonurus heterophyllus showed significant AChE inhibitory activity...
  58. Zhu Q, Cai W, Sha X, Ma G, Zheng Y, Shi X, et al. Quantification of leonurine, a novel potential cardiovascular agent, in rat plasma by liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic study in rats. Biomed Chromatogr. 2012;26:518-23 pubmed publisher
    ..73-105.42%. The validated HPLC-MS/MS method was successfully applied to the pharmacokinetic study in rats following oral administration of leonurine...
  59. Xin H, Gu M, Wang W, Huang S, Li F, Cai H, et al. Effects of Leonurine on L-type calcium channel in rat ventricular myocytes. Biol Pharm Bull. 2012;35:1249-56 pubmed
    ..We conclude that Leo inhibits L-type calcium channels in cardiomyocytes...
  60. Kuchta K, Ortwein J, Rauwald H. Leonurus japonicus, Leonurus cardiaca, Leonotis leonurus: a novel HPLC study on the occurrence and content of the pharmacologically active guanidino derivative leonurine. Pharmazie. 2012;67:973-9 pubmed
    ..It is commonly regarded as the predominant active principle of Leonurus and Leonotis drugs (subfamily Lamioideae), though its presence has only been unambiguously proven for the aerial ..
  61. Narukawa Y, Niimura A, Noguchi H, Tamura H, Kiuchi F. New diterpenoids with estrogen sulfotransferase inhibitory activity from Leonurus sibiricus L. J Nat Med. 2014;68:125-31 pubmed publisher
    Four new diterpenoids (1-4), along with eight known diterpenoids (5-12) were isolated from the acetone extract of Leonurus herb (aerial parts of Leonurus sibiricus L.)...
  62. Kuchta K, Volk R, Rauwald H. Stachydrine in Leonurus cardiaca, Leonurus japonicus, Leonotis leonurus: detection and quantification by instrumental HPTLC and 1H-qNMR analyses. Pharmazie. 2013;68:534-40 pubmed
    ..acid) may be regarded as an essential active principle of the aerial parts of Leonurus japonicus Houtt. (Leonuri herba, yimucao; Chin.Ph...
  63. Bernatoniene R, Bernatoniene J, Ramanauskiene K. [The analysis of tincture for improvement of blood circulation]. Medicina (Kaunas). 2004;40:758-61 pubmed
    ..The refractive index, relative density, loss of drying and ethanol concentration were determined according to European Pharmacopoeia Requirements...
  64. Zheng L, Fang C. [Effect of Leonurus Heterophyllus Sweet on tissue factor transcription and expression in human umbilical vein endothelial cells in vitro]. Nan Fang Yi Ke Da Xue Xue Bao. 2007;27:805-8 pubmed
    To investigate the effect of Leonurus Heterophyllus Sweet, (LHS) on tissue factor (TF) transcription and expression induced by thrombin in human umbilical vein endothelial cells (HUVECs).
  65. Zhao X, Sun X, Zhang Z, Hui J. [Experimental studies on compound Duzhong Jiangya prescription by semi-bionic extraction]. Zhongguo Zhong Yao Za Zhi. 2007;32:2247-52 pubmed
    ..Optimize the technic condition of Duzhong Jiangya prescription with Semi-bionic Extraction...
  66. Masteikova R, Muselik J, Bernatoniene J, Majiene D, Savickas A, Malinauskas F, et al. [Antioxidant activity of tinctures prepared from hawthorn fruits and motherwort herb]. Ceska Slov Farm. 2008;57:35-8 pubmed
    ..In the hawthorn fruit tincture it was epicatechine and hyperosid, whereas in the motherwort herb tincture it was rutin...
  67. Shin H, Kim S, Kang S, Chang I, Kim S, Jeon H, et al. Anti-inflammatory activity of Motherwort (Leonurus sibiricus L.). Immunopharmacol Immunotoxicol. 2009;31:209-13 pubmed publisher
    ..MW inhibited secretion of TNF-alpha, IL-6, and IL-8 possibly by inhibiting NF-kappaB activation. These results indicate that MW may be helpful in regulating inflammatory diseases...
  68. Cong Y, Guo J, Wang T, Li M, Li K, Wang J, et al. [Chemical constituents and antitumor activity on leukemia K562 cell of Leonurus heterophyllus]. Zhongguo Zhong Yao Za Zhi. 2009;34:1816-8 pubmed
    The chemical constituents of Leonurus heterophyllus were separated and purified by repeated column chromatography on silica gel, HPD 100, Sephadex LH-20, and PHPLC. Each compound was characterized by spectroscopic and physical data...
  69. Liu X, Pan L, Zhu Y. Active chemical compounds of traditional Chinese medicine Herba Leonuri: implications for cardiovascular diseases. Clin Exp Pharmacol Physiol. 2012;39:274-82 pubmed publisher
    ..3.?The present review provides an overview of the chemical composition, with a focus on biological activity, of Herba Leonuri to stimulate new studies on traditional Chinese medicine...
  70. Pitschmann A, Zehl M, Heiss E, Purevsuren S, Urban E, Dirsch V, et al. Quantitation of phenylpropanoids and iridoids in insulin-sensitising extracts of Leonurus sibiricus L. (Lamiaceae). Phytochem Anal. 2016;27:23-31 pubmed publisher
    b>Leonurus sibiricus L. is regularly used in traditional Mongolian medicine including for the treatment of symptoms of diabetes mellitus.
  71. Zitkevicius V, Savickiene N, Abdrachmanovas O, Ryselis S, Masteikova R, Chalupova Z, et al. [Estimation of maximum acceptable concentration of lead and cadmium in plants and their medicinal preparations]. Medicina (Kaunas). 2003;39 Suppl 2:117-21 pubmed
    ..are produced using medicinal plants. The objective of this research was to study the impurities of heavy metals (lead, cadmium) in medicinal plants and some drug preparations...
  72. Giang P, Son P, Matsunami K, Otsuka H. New bis-spirolabdane-type diterpenoids from Leonurus heterophyllus Sw. Chem Pharm Bull (Tokyo). 2005;53:1475-9 pubmed
    ..C, together with hispanone and galeopsin were isolated from the aerial parts of the medicinal plant Leonurus heterophyllus SW. (Lamiaceae) grown in Vietnam. Their structures were determined by spectroscopic analyses...
  73. Makarov V, Aleksandrova A, Shikov A, Shiler L, Ryzhenkov V. [Experimental and clinical study of preparation Iridol action on the central nevros system]. Eksp Klin Farmakol. 2006;69:23-5 pubmed
    ..This effect of Iridol was approximately the same as by diazepam. In patients with arterial hypertension I - II degree, accompanied by psychoemotional disturbances, the use of Iridol in complex treatment increases efficacy of therapy...
  74. Lin J, Lin Q, Liu X, Yan J, He J, Li L, et al. [Multi-center study of motherwort injection to prevent postpartum hemorrhage after caesarian section]. Zhonghua Fu Chan Ke Za Zhi. 2009;44:175-8 pubmed
    To evaluate the efficacy and safety of motherwort (herba leonuri/leonurus heterophyllus sweet) injection for preventing postpartum hemorrhage after caesarian section.
  75. Moon H. Three diterpenes from Leonurus japonicus Houtt protect primary cultured rat cortical cells from glutamate-induced toxicity. Phytother Res. 2010;24:1256-9 pubmed publisher
    To examine the cytoprotective effects of Leonurus japonicus Houtt, its protection against the glutamate-induced toxicity in primary cortical cultured neurons was tested...
  76. Zhang Y, Deng S, Qu L, An Y, Wu C, Han L, et al. Rare syringyl acylated flavonol glycosides from the aerial parts of Leonurus japonicus Houtt. Molecules. 2013;18:2967-77 pubmed publisher
    ..A (1), B (2), C (3), D (4), and E (5), together with one known one 6 were obtained from the aerial parts of Leonurus japonicus...
  77. Peng F, Xiong L, Zhao X. A bicyclic diterpenoid with a new 15,16-dinorlabdane carbon skeleton from Leonurus japonicus and its coagulant bioactivity. Molecules. 2013;18:13904-9 pubmed publisher
    ..2, together with three known ergosterols 3-5, were isolated from the EtOAc-soluble portion of the EtOH extract of Leonurus japonicus. Their structures were elucidated by physical and spectroscopic analysis...
  78. Bernatoniene J, Bernatoniene R, Jakstas V, Malinauskas F, Brusokas V. [Production technology and analysis of blood circulation improving tincture]. Medicina (Kaunas). 2003;39 Suppl 2:76-9 pubmed
    This article deals with the production of the tincture of Ginkgo biloba leaves, Crataegus fruits and Leonurus herbs while selecting an extractant, the size of particles in a raw material and possible methods of extraction...
  79. Sun J, Huang S, Zhu Y, Whiteman M, Wang M, Tan B, et al. Anti-oxidative stress effects of Herba leonuri on ischemic rat hearts. Life Sci. 2005;76:3043-56 pubmed
    ..Its effects of scavenging free radicals and inhibiting the formation of reactive oxygen species may play a key role in protecting the endogenous antioxidant system from oxidative stress in vivo...
  80. Agnihotri V, ElSohly H, Smillie T, Khan I, Walker L. New labdane diterpenes from Leonurus cardiaca. Planta Med. 2008;74:1288-90 pubmed publisher
    b>Leonurus cardiaca L. has been used in oriental medicine against several types of disorders...
  81. Yin J, Zhang Z, Yu W, Liao J, Luo X, Shen Y. Stachydrine, a major constituent of the Chinese herb leonurus heterophyllus sweet, ameliorates human umbilical vein endothelial cells injury induced by anoxia-reoxygenation. Am J Chin Med. 2010;38:157-71 pubmed
    Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet, which is used in clinics to promote blood circulation and dispel blood stasis...
  82. Schmidt S, Jakab M, Jav S, Streif D, Pitschmann A, Zehl M, et al. Extracts from Leonurus sibiricus L. increase insulin secretion and proliferation of rat INS-1E insulinoma cells. J Ethnopharmacol. 2013;150:85-94 pubmed publisher
    ..We evaluated the effect of extracts from the plant Leonurus sibiricus L...
  83. Brenyo A, Aktas M. Review of complementary and alternative medical treatment of arrhythmias. Am J Cardiol. 2014;113:897-903 pubmed publisher
    ..We stress persistent vigilance on the part of the provider in discussing the use of herbal or other CAM agents within the arrhythmia population...
  84. Boalino D, McLean S, Reynolds W, Tinto W. Labdane diterpenes of Leonurus sibiricus. J Nat Prod. 2004;67:714-7 pubmed
    ..6) and 15-epi-sibiricinones D and E (5 and 7), and the flavone genkwanin were isolated from the aerial parts of Leonurus sibiricus...
  85. Chao Z, Ma L, Zhou X. [Determination of stachydrine and leonurine in Herba Leonuri by ion- pair reversed-phase high-performance liquid chromatography]. Di Yi Jun Yi Da Xue Xue Bao. 2004;24:1223-6 pubmed
    To establish a high-performance liquid chromatography (HPLC) for determining stachydrine and leonurine contents in the crude drug of Yimu Cao, a Chinese motherwort herb(Herba Leonuri, the aerial part of Leonurus japonicus).
  86. Shikov A, Pozharitskaya O, Makarov V, Demchenko D, Shikh E. Effect of Leonurus cardiaca oil extract in patients with arterial hypertension accompanied by anxiety and sleep disorders. Phytother Res. 2011;25:540-3 pubmed publisher
    b>Leonurus cardiaca L. (Lamiaceae) is used traditionally for its sedative, hypotensive and cardiotonic effects...
  87. Liu X, Pan L, Deng H, Xiong Q, Wu D, Huang G, et al. Leonurine (SCM-198) attenuates myocardial fibrotic response via inhibition of NADPH oxidase 4. Free Radic Biol Med. 2013;54:93-104 pubmed publisher
    ..In conclusion, our results provide the first evidence that leonurine could prevent cardiac fibrosis and the activation of cardiac fibroblasts partly through modulation of a Nox4-ROS pathway...
  88. Chinwala M, Gao M, Dai J, Shao J. In vitro anticancer activities of Leonurus heterophyllus sweet (Chinese motherwort herb). J Altern Complement Med. 2003;9:511-8 pubmed
    To investigate the anticancer activities of Chinese motherwort herb (Leonurus heterophyllus Sweet; LHS).
  89. Romero González R, Avila Núñez J, Aubert L, Alonso Amelot M. Labdane diterpenes from Leonurus japonicus leaves. Phytochemistry. 2006;67:965-70 pubmed
    ..and (9alpha,13R);15,16-diepoxy-6beta-hydroxylabd-14-en-7-one (iso-preleoheterin) were isolated from the leaves of Leonurus japonicus, in addition to the previously reported preleoheterin...
  90. Wojtyniak K, Szymanski M, Matławska I. Leonurus cardiaca L. (motherwort): a review of its phytochemistry and pharmacology. Phytother Res. 2013;27:1115-20 pubmed publisher
    b>Leonurus cardiaca is a perennial plant indigenous to central Europe and Scandinavia, but it is also found in the area spanning temperate Russia to central Asia...
  91. Xiong L, Zhou Q, Peng C, Xie X, Guo L, Li X, et al. Sesquiterpenoids from the herb of Leonurus japonicus. Molecules. 2013;18:5051-8 pubmed publisher
    ..2), along with six known compounds 3-8, were isolated from the EtOH extract of the herb of Leonurus japonicus. Their structures were elucidated by physical and spectroscopic analysis...
  92. Krasteva S, Heiss E, Krenn L. Optimization and application of a fluorimetric assay for the identification of histone deacetylase inhibitors from plant origin. Pharm Biol. 2011;49:658-68 pubmed publisher
    ..To accelerate the isolation of potential candidates from plants bioassays well suited for screenings of extracts are an indispensable prerequisite...