isodon

Summary

Summary: A plant genus of the family LAMIACEAE used in TRADITIONAL CHINESE MEDICINE.

Top Publications

  1. Sun H, Huang S, Han Q. Diterpenoids from Isodon species and their biological activities. Nat Prod Rep. 2006;23:673-98 pubmed
    b>Isodon species (Labiatae) are widely distributed plants, many of which are used in folk medicine. Over the past twenty years, they have received considerable phytochemical and biological attention...
  2. Li L, Li G, Ding L, Yang L, Zhao Y, Pu J, et al. ent-Kaurane Diterpenoids from Isodon nervosus. J Nat Prod. 2008;71:684-8 pubmed publisher
    ..other new ent-kaurane diterpenoids, nervonins B-J ( 2- 10), along with 10 known ones ( 11- 20), were isolated from Isodon nervosus. Their structures were elucidated by detailed spectroscopic analysis...
  3. Kim B, Koppula S, Kim I, Lim H, Hong S, Han S, et al. Anti-neuroinflammatory activity of Kamebakaurin from Isodon japonicus via inhibition of c-Jun NH?-terminal kinase and p38 mitogen-activated protein kinase pathway in activated microglial cells. J Pharmacol Sci. 2011;116:296-308 pubmed
    ..The present study investigated the effects of Kamebakaurin (KMBK), a kaurane diterpene isolated from Isodon japonicus HARA (Labiatae), on the production of pro-inflammatory mediators in lipopolysaccharide (LPS)-stimulated ..
  4. Li S, Niu X, Peng L, Zhang H, Yao P, Sun H. ent-Kaurane diterpenoids from the leaves of Isodon xerophilus. Planta Med. 2002;68:946-8 pubmed
    From the ethanolic extract of the leaves of Isodon xerophilus, three new ent-kaurane diterpenoids named xerophilusins L-N (1 - 3), together with three known ones designated as rabdoternin A (4), longikaurin F (5) and ponicidin (6), were ..
  5. Zhang J, Han Q, Zhao A, Sun H. Diterpenoids from Isodon japonica. Fitoterapia. 2003;74:435-8 pubmed
    ..maoyecrystal F (1) and its acetonide derivative (2), together with seven known compounds, lasiodonin, maoyerabdosin, odonicin, enmenin, oridonin, beta-sitosterol and daucosterol, were isolated from the leaves of Isodon japonica.
  6. Han Q, Xiao W, Shen Y, Sun H. Ent-kaurane diterpenoids from Isodon rubescens var. rubescens. Chem Pharm Bull (Tokyo). 2004;52:767-9 pubmed
    ..ones, xindongnins A and B (6, 7), melissoidesins G (8), dawoensin A (9), and glabcensin V (10) were isolated from Isodon rubescens var. rubescens...
  7. Ding L, Liu G, Yang D, Wang H, Wang L, Sun K. Cytotoxic ent-kaurane diterpenoids from Isodon weisiensis C. Y. Wu. Pharmazie. 2005;60:458-60 pubmed
    A new ent-kaurane diterpenoid, weisiensin B (1), was isolated from the leaves of Isodon weisiensis C. Y. Wu, along with four known ones, kamebanin (2), kamebacetal A (3), macrocalyxin D (4) and excisanin D (5)...
  8. Hong S, Lee S, Han X, Hwang J, Lee C, Lee D, et al. ent-Kaurane diterpenoids from Isodon japonicus. J Nat Prod. 2008;71:1055-8 pubmed publisher
    ..B (12), lasiokaurin (13), megathyrin A (14), and loxothyrin A (15), were isolated from the aerial parts of Isodon japonicus...
  9. Thirugnanasampandan R, Jayakumar R. Cytotoxic and anticarcinogenic activity of the ent-kaurene diterpenoid, melissoidesin, from Isodon wightii (Bentham) H. Hara. Nat Prod Res. 2009;23:1499-506 pubmed publisher
    b>Isodon wightii is a common plant found in the Western Ghats of South India. The ent-kaurene diterpenoid melissoidesin, isolated from the leaves of I...

More Information

Publications122 found, 100 shown here

  1. Zhang H, Pu J, Wang Y, He F, Zhao Y, Li X, et al. Four new ent-kauranoids from Isodon rubescens var. lushanensis and data reassignment of dayecrystal B. Chem Pharm Bull (Tokyo). 2010;58:56-60 pubmed
    Four new 7, 20-epoxy-ent-kauranoids, rubluanins A-D (1-4) and eleven known ones, were isolated from Isodon rubescens var. lushanensis, and their structures were elucidated by spectroscopic analysis...
  2. Wang W, Du X, Li X, Wu H, Liu X, Shang S, et al. New bicyclo[3.1.0]hexane unit ent-kaurane diterpene and its seco-derivative from Isodon eriocalyx var. laxiflora. Org Lett. 2012;14:302-5 pubmed publisher
    ..its seco-derivative, neolaxiflorin B (2), along with two known compounds 3 and 4 were isolated from the leaves of Isodon eriocalyx var. laxiflora...
  3. Liu J, Yang F, Zhang Y, Li J. Studies on the cell-immunosuppressive mechanism of Oridonin from Isodon serra. Int Immunopharmacol. 2007;7:945-54 pubmed
    Distinct effects of Oridonin and Lasiodonin, which were extracted from Isodon serra was compared by the ratio of IC(50) versus EC(50), the therapeutic index...
  4. Yu Z, Liang Y, Xiao H, Shan Y, Dong B, Huang R, et al. Melissoidesin G, a diterpenoid purified from Isodon melissoides, induces leukemic-cell apoptosis through induction of redox imbalance and exhibits synergy with other anticancer agents. Int J Cancer. 2007;121:2084-94 pubmed
    Melissoidesin G (MOG) is a new diterpenoid purified from Isodon melissoides, a plant used in Chinese traditional medicine as antitumor and anti-inflammatory agents...
  5. Zhao Y, Huang S, Yang L, Pu J, Xiao W, Li L, et al. Cytotoxic ent-kaurane diterpenoids from Isodon henryi. Planta Med. 2009;75:65-9 pubmed publisher
    Chromatographic fractionation of the extract of Isodon henryi resulted in the isolation of seven new ENT-kaurane diterpenoids, named minheryins A-G (1-7), together with the six known ENT-kaurane diterpenoids leukamenin F (8), excisoidesin ..
  6. Deng R, Tang J, Xia L, Li D, Zhou W, Wang L, et al. ExcisaninA, a diterpenoid compound purified from Isodon MacrocalyxinD, induces tumor cells apoptosis and suppresses tumor growth through inhibition of PKB/AKT kinase activity and blockade of its signal pathway. Mol Cancer Ther. 2009;8:873-82 pubmed publisher
    b>Isodon diterpenoids have received considerable phytochemical and biological attention for their strong antitumor activity with low toxicity...
  7. Harris E, Klooster M. Development of microsatellite markers for the medicinal plant Isodon rubescens (Lamiaceae) and related species. Am J Bot. 2011;98:e293-5 pubmed publisher
    Microsatellite markers were developed for the medicinal plant Isodon rubescens to investigate genetic variability of the species and, in future studies, to assess its relation to the content of pharmacologically active chemicals produced ..
  8. Hong S, Lee S, Lee C, Han X, Choe S, Kim N, et al. Dimeric ent-kaurane diterpenoids from Isodon excisus. J Nat Prod. 2011;74:2382-7 pubmed publisher
    Five new dimeric ent-kauranoids, biexcisusins A-E (1-5), were isolated from the aerial parts of Isodon excisus...
  9. Wang W, Li X, Du X, Wu H, Liu X, Su J, et al. Laxiflorolides A and B, epimeric bishomoditerpene lactones from Isodon eriocalyx. J Nat Prod. 2012;75:1102-7 pubmed publisher
    ..All of the compounds isolated were evaluated for their cytotoxicity against five tumor cell lines. Compounds 3, 6, and 8 showed remarkable cytotoxic activity against certain cell lines compared with the positive control...
  10. Zou J, Du X, Pang G, Shi Y, Wang W, Zhan R, et al. Ternifolide A, a new diterpenoid possessing a rare macrolide motif from Isodon ternifolius. Org Lett. 2012;14:3210-3 pubmed publisher
    ..and C-15, along with ternifolide B (2), a nor-diterpenoid, and ternifolide C (3) were isolated from the leaves of Isodon ternifolius. Both H-8 and H-9 being ?-orientations in compound 1 were found for the first time...
  11. Niu X, Li S, Mei S, Na Z, Zhao Q, Lin Z, et al. Cytotoxic 3,20-epoxy-ent-kaurane diterpenoids from Isodon eriocalyx var. laxiflora. J Nat Prod. 2002;65:1892-6 pubmed
    ..laxiflorins J-M (1-4), along with maoecrystal A (5) and maoecrystal P (6), were isolated from the leaves of Isodon eriocalyx var. laxiflora. Their structures were determined by spectroscopic analyses...
  12. Abbaskhan A, Choudhary M, Tsuda Y, Parvez M, Atta Ur Rahman -, Shaheen F, et al. A new diepoxy-ent-kauranoid, rugosinin, from Isodon rugosus. Planta Med. 2003;69:94-6 pubmed
    A new diterpenoid, rugosinin (1), isolated from Isodon rugosus, with absolute configuration was proved by single-crystal X-ray diffraction analysis, to be the member of a rare class of C-20/C-7 and C-20/C-14 diepoxy- ent-kauranoids...
  13. Han Q, Li M, Li S, Mou Y, Lin Z, Sun H. Ent-kaurane diterpenoids from Isodon rubescens var. lushanensis. Chem Pharm Bull (Tokyo). 2003;51:790-3 pubmed
    ..B (10), rabdoternins A and B (11 and 12), enmenol (13), epinodosin (14), and inflexusin (15), were isolated from Isodon rubescens var. lushanensis, and the structures were elucidated by spectroscopic analysis...
  14. Leung C, Grill S, Lam W, Han Q, Sun H, Cheng Y. Novel mechanism of inhibition of nuclear factor-kappa B DNA-binding activity by diterpenoids isolated from Isodon rubescens. Mol Pharmacol. 2005;68:286-97 pubmed
    ..Several diterpenoids, oridonin, ponicidin, xindongnin A, and xindongnin B were isolated from the herb Isodon rubescens...
  15. Sienkiewicz P, Ciolino H, Leslie B, Hergenrother P, Singletary K, Yeh G. A novel synthetic analogue of a constituent of Isodon excisus inhibits transcription of CYP1A1, -1A2 and -1B1 by preventing activation of the aryl hydrocarbon receptor. Carcinogenesis. 2007;28:1052-7 pubmed
    We investigated the effect of a novel synthetic analogue of a constituent from the Chinese medicinal herb Isodon excisus, 3-(3-methoxy-phenyl)-N-(3, 4, 5-trimethoxy-phenyl)-acrylamide (compound 343), on the carcinogen activation pathway ..
  16. Hong S, Lee S, Han X, Jin H, Lee J, Lee D, et al. Kaurane diterpenoids from Isodon excisus inhibit LPS-induced NF-kappaB activation and NO production in macrophage RAW264.7 cells. J Nat Prod. 2007;70:632-6 pubmed
    ..for plant-derived compounds that inhibit the activation of NF-kappaB, the methanol extract of the aerial parts of Isodon excisus was found to have significant inhibitory effects on the activation of NF-kappaB in murine macrophage ..
  17. Zhao Y, Pu J, Huang S, Ding L, Wu Y, Li X, et al. ent-Kaurane diterpenoids from Isodon pharicus. J Nat Prod. 2009;72:988-93 pubmed publisher
    Phytochemical investigation of the aerial parts of Isodon pharicus led to the isolation of 13 new ent-kaurane diterpenoids, compounds 1-13, together with 12 known analogues (14-25)...
  18. Li L, Li G, Pu J, Xiao W, Ding L, Sun H. ent-Kaurane and cembrane diterpenoids from Isodon sculponeatus and their cytotoxicity. J Nat Prod. 2009;72:1851-6 pubmed publisher
    ..new ent-kauranoids, sculponins D-L (1-9), and 14 known diterpenoids (10-23) were isolated from the aerial parts of Isodon sculponeatus...
  19. He F, Xiao W, Pu J, Wu Y, Zhang H, Li X, et al. Cytotoxic ent-kaurane diterpenoids from Isodon sinuolata. Phytochemistry. 2009;70:1462-6 pubmed publisher
    Five (1-5) ent-kaurane diterpenoids and 17 other known ones, were isolated from the leaves and stems of Isodon sinuolata...
  20. Li X, Xiao W, Pu J, Ban L, Shen Y, Weng Z, et al. Cytotoxic ent-kaurene diterpenoids from Isodon phyllostachys. Phytochemistry. 2006;67:1336-40 pubmed
    ..12), oleanolic acid (13) and daucosterol (14), were isolated from aerial parts of Isodon phyllostachys...
  21. Li J, Du J, Sun L, Liu J, Quan Z. Anti-inflammatory function of Nodosin via inhibition of IL-2. Am J Chin Med. 2010;38:127-42 pubmed
    In order to explore the anti-inflammatory effects of Nodosin from Isodon serra, a traditional Chinese herb medicine, mouse T lymphocytes were incubated with Nodosin...
  22. Wan J, Liu M, Jiang H, Yang J, Du X, Li X, et al. Bioactive ent-kaurane diterpenoids from Isodon serra. Phytochemistry. 2016;130:244-51 pubmed publisher
    ..H, serrin I, and 15-acetylenanderianin N), along with seven known ones, were isolated from the aerial parts of Isodon serra...
  23. Li L, Li G, Li S, Weng Z, Xiao W, Han Q, et al. Cytotoxic ent-kauranoids from Isodon parvifolius. Chem Biodivers. 2006;3:1031-8 pubmed
    ..parvifoline AA (2), and parvifoline AB (3), together with 14 known compounds, were isolated from the leaves of Isodon parvifolius...
  24. White W, Ebert D, Naylor G. Revision of the genus <i>Centrophorus</i> (Squaliformes: Centrophoridae): Part 2-Description of two new species of <i>Centrophorus</i> and clarification of the status of <i>Centrophorus</i> <i>lusitanicus<. Zootaxa. 2017;4344:86-114 pubmed publisher
    ..longipinnis. The two species are similar morphologically and belong to the long-snout Centrophorus group (e.g. C. isodon and C. harrissoni) but are clearly separable based on their very long first dorsal fins...
  25. Rashid N, Gbedomon R, Ahmad M, Salako V, Zafar M, Malik K. Traditional knowledge on herbal drinks among indigenous communities in Azad Jammu and Kashmir, Pakistan. J Ethnobiol Ethnomed. 2018;14:16 pubmed publisher
    ..00%), roots (17.25%), and fruits (16.47%). Based on UV, the top five most used species were Valeriana jatamansi, Isodon rugosus, Onopordum acanthium, Acacia nilotica, and Viola canescens; and the UV was similar among gender and age ..
  26. Li S, Wang J, Niu X, Shen Y, Zhang H, Sun H, et al. Maoecrystal V, cytotoxic diterpenoid with a novel C19 skeleton from Isodon eriocalyx (Dunn.) hara. Org Lett. 2004;6:4327-30 pubmed
    ..skeleton, was isolated from the leaves of a Chinese medicinal herb, Isodon eriocalyx...
  27. Li L, Huang S, Peng L, Li G, Xiao W, Zhou Y, et al. Ent-abietane and ent-labdane diterpenoids from Isodon parvifolius. Chem Pharm Bull (Tokyo). 2006;54:1050-2 pubmed
    A phytochemical investigation on the leaves of Isodon parvifolius yielded three new ent-abietanoids parvifolines L-N (1-3), together with five known ent-abietanoids (4-8) and one known ent-labdane diterpenoid (9)...
  28. Du Y, Liu P, Zhu H, Shi X, Zhao C, Wang N, et al. A sensitive analysis method for 7 diterpenoids in rat plasma by liquid chromatography-electrospray ionization mass spectrometry and its application to pharmacokinetic study of Isodon serra extract. J Chromatogr A. 2011;1218:7771-80 pubmed publisher
    ..The proposed method was further applied to investigate the pharmacokinetics of all analytes after a single oral administration of Isodon serra extract to rats.
  29. Han Q, Xiang W, Li R, Li M, Li S, Sun H. Cytotoxic ent-kaurane diterpenoids from Isodon rubescens var. rubescens. Planta Med. 2004;70:269-72 pubmed
    ..and B ( 6 and 7), melissoidesin G ( 8), dawoensin A ( 9), and glabcensin V ( 10), were isolated from the leaves of Isodon rubescens var. rubescens, and structurally elucidated...
  30. Li L, Li G, Huang S, Xiao W, Liao X, Lou L, et al. Antiproliferative ent-Kauranoids from Isodon parvifolius. Planta Med. 2006;72:740-5 pubmed
    ..rosthorin A (11), longikaurin E (12), adenolin D (13) and longikaurin B (14), were isolated from the leaves of Isodon parvifolius. Their structures were determined by means of spectroscopic analysis...
  31. Chen J, Wang S, Lu X. Study on Wangzaozin-A-Inducing Cancer Apoptosis and Its Theoretical Protein Targets. Technol Cancer Res Treat. 2016;15:589-96 pubmed publisher
    Wangzaozin A is the most representative cytotoxic C-20-nonoxide compound of Isodon plants of Labiatae. The protein targets of the 2 isomers (X and X') of Wangzaozin A are, respectively, extracted from target fishing dock Web site...
  32. Liu X, Zhan R, Wang W, Du X, Li Y, Zhang P, et al. Three new 11,20-epoxy-ent-kauranoids from Isodon rubescens. Arch Pharm Res. 2012;35:2147-51 pubmed publisher
    ..named jianshirubesins D-F (1-3), along with one known analogue (4), were isolated from the aerial parts of Isodon rubescens. Their structures were established by analysis of spectroscopic data...
  33. Zhang J, He Z, Chen Z, Wang Y, Bai S, Sun H. Cytotoxic ent-kaurane diterpenoids from Isodon macrophyllus. J Asian Nat Prod Res. 2009;11:693-7 pubmed publisher
    ..C (7), rabdosin B (8), isodonal (9), shikokianin (10), and effusanin A (11), were isolated from the leaves of Isodon macrophyllus. The structures of the new compounds were elucidated using 1D and 2D NMR spectroscopy...
  34. Ma Y, Ke Y, Zi X, Zhao W, Shi X, Liu H. Jaridonin, a novel ent-kaurene diterpenoid from Isodon rubescens, inducing apoptosis via production of reactive oxygen species in esophageal cancer cells. Curr Cancer Drug Targets. 2013;13:611-24 pubmed
    b>Isodon rubescens, a Chinese herb, has been used as a folk, botanical medicine in China for inflammatory diseases and cancer treatment for many years...
  35. Yeoman J, Mak V, REISMAN S. A unified strategy to ent-kauranoid natural products: total syntheses of (-)-trichorabdal A and (-)-longikaurin E. J Am Chem Soc. 2013;135:11764-7 pubmed publisher
    ..2.1]octane framework. These studies, taken together with our previous synthesis of (-)-maoecrystal Z, demonstrate that three architecturally distinct ent-kauranoids can be prepared from a common spirolactone intermediate. ..
  36. He F, Bai Y, Wang J, Wei J, Yu C, Li S, et al. Isolation and purification of oridonin from the whole plant of Isodon rubescens by high-speed counter-current chromatography. Molecules. 2011;16:7949-57 pubmed publisher
    ..counter-current chromatography (HSCCC) was successfully used for isolation and purification of oridonin from Isodon rubescens by using a two-phase-solvent system composed of n-hexane-ethyl acetate-methanol-water (2.8:5:2...
  37. Mo X, Zeng Q, Huang S, Cai Y, Wang Y, Yan Z. [Identification of herba rabdosiae serrae from different plant resources by RAPD method]. Zhong Yao Cai. 2012;35:1388-91 pubmed
    ..12 primers were selected with polymorphism and 7 of them showed good polymorphism in RAPD map. RAPD method can be used to identify the plant resources of Herba Rabdosiae Serrae. ..
  38. Xu H, Huang Y, Wu Y, Zhao Y, Xiao W, Lin Q, et al. Pharicin A, a novel natural ent-kaurene diterpenoid, induces mitotic arrest and mitotic catastrophe of cancer cells by interfering with BubR1 function. Cell Cycle. 2010;9:2897-907 pubmed
    ..functional characterization of a new ent-kaurene diterpenoid termed pharicin A, which was originally isolated from Isodon, a perennial shrub frequently used in Chinese folk medicine for tumor treatment...
  39. Shi X, Ding L, Zhou W, Ji Y, Wang J, Wang H, et al. Pro-Apoptotic Effects of JDA-202, a Novel Natural Diterpenoid, on Esophageal Cancer Through Targeting Peroxiredoxin I. Antioxid Redox Signal. 2017;27:73-92 pubmed publisher
    ..JDA-202, a novel natural compound isolated from Isodon rubescens (Labiatae), was proved to possess strong anti-proliferative activities on those cell lines...
  40. Jin B, Cui G, Guo J, Tang J, Duan L, Lin H, et al. Functional Diversification of Kaurene Synthase-Like Genes in Isodon rubescens. Plant Physiol. 2017;174:943-955 pubmed publisher
    i>Ent-kaurene diterpenoids are the largest group of known Isodon diterpenoids...
  41. Thirugnanasampandan R, Jayakumar R, Narmatha Bai V, Martin E, Rajendra Prasad K. Antiacetylcholinesterase and antioxidant ent-Kaurene diterpenoid, melissoidesin from Isodon wightii (Bentham) H. Hara. Nat Prod Res. 2008;22:681-8 pubmed publisher
    The ent kaurene diterpenoid, melissoidesin was isolated from the acetone extract of the leaves of Isodon wightii and the structure was designated as 3beta, 11beta, 15beta-trihydroxy-6alpha-acetoxy-ent-kaur-16-ene based on spectral data ..
  42. Zhan R, Li X, Du X, Wang W, Dong K, Su J, et al. Bioactive ent-kaurane diterpenoids from Isodon rosthornii. J Nat Prod. 2013;76:1267-77 pubmed publisher
    ..new ent-kauranoids, isorosthins B-P (2-16), along with 22 known analogues were isolated from the aerial parts of Isodon rosthornii. The structures of 1-16 were elucidated by means of spectroscopic analysis...
  43. Yang N, Xiong A, Wang R, Yang L, Wang Z. Quality Evaluation of Traditional Chinese Medicine Compounds in Xiaoyan Lidan Tablets: Fingerprint and Quantitative Analysis Using UPLC-MS. Molecules. 2016;21:83 pubmed publisher
    ..Moreover, the combined approach can potentially differentiate the origin, determine the authenticity and assess the overall quality of the formulae. ..
  44. Isobe T, Nagata K. [Study on the antibacterial activity of compounds from the isodon species]. Yakugaku Zasshi. 2010;130:447-50 pubmed
    We investigated antibacterial activities of ten compounds from Isodon species against five strains of Escherichia coli, Staphylococcus epidermidis, Serratia marcescens, Streptococcus mutans, and Helicobacter pylori...
  45. Gao S, Li J, Qu X, Zhu N, Ji Y. Downregulation of Cdk1 and cyclinB1 expression contributes to oridonin-induced cell cycle arrest at G2/M phase and growth inhibition in SGC-7901 gastric cancer cells. Asian Pac J Cancer Prev. 2014;15:6437-41 pubmed
    ..The agent also decreased the protein expression of cyclinB1 and CDK1. Oridonin may inhibit SGC-7901 growth and block the cells in the G2/M phase by decreasing Cdk1 and cyclinB1 proteins. ..
  46. Han Q, Zhao A, Zhang J, Lu Y, Zhang L, Zheng Q, et al. Cytotoxic constituents of Isodon rubescens var. lushiensis. J Nat Prod. 2003;66:1391-4 pubmed
    ..gardenin D, 5,3',4'-trihydroxy-6,7,8-trimethoxyflavone, pedalitin, and quercetin, were isolated from the leaves of Isodon rubescens var. lushiensis...
  47. Du Y, Liu P, Yuan Z, Jin Y, Zhang X, Sheng X, et al. Simultaneous qualitative and quantitative analysis of 28 components in Isodon rubescens by HPLC-ESI-MS/MS. J Sep Sci. 2010;33:545-57 pubmed publisher
    ..and quantitatively determine the 28 components including 19 diterpenoids, 6 phenolic acids and 3 flavonoids in Isodon rubescens, an important traditional Chinese medicine...
  48. Xie R, Yan F, Hai G, Hou R, Ding M, Bai Y. Two new diterpenoids and other constituents from Isodon rubescens. Fitoterapia. 2011;82:726-30 pubmed publisher
    ..2), together with ten known compounds (5-14) were isolated from the leaves of Isodon rubescens...
  49. Xiang W, Na Z, Li S, Li M, Li R, Tian Q, et al. Cytotoxic diterpenoids from Isodon enanderianus. Planta Med. 2003;69:1031-5 pubmed
    ..B (8), rabdocoetsin D (9), megathyrin A (10), megathyrin B (11) were isolated from the aerial parts of Isodon enanderianus. Their structures were determined by spectral means...
  50. Zhou Y, Yang B, Yang J, Huang S, Sun H, Xu H, et al. Electrospray ionization tandem mass spectrometric analysis of ent-6,7-seco-kaurane diterpenoids from the Isodon species. Rapid Commun Mass Spectrom. 2009;23:138-46 pubmed publisher
    ..and differentiation of the enmein and spiro-lactone types of ent-6,7-seco-kaurane diterpenoids from Isodon species...
  51. Ding L, Zhou Q, Wang L, Wang W, Zhang S, Liu B. Comparison of cytotoxicity and DNA damage potential induced by ent-kaurene diterpenoids from Isodon plant. Nat Prod Res. 2011;25:1402-11 pubmed publisher
    The cytotoxicity of six ent-kaurene diterpenoids isolated from the leaves of Isodon japonica (Burm.f.) Hara var...
  52. Zhou M, Geng H, Zhang H, Dong K, Wang W, Du X, et al. Scopariusins, a new class of ent-halimane diterpenoids isolated from Isodon scoparius, and biomimetic synthesis of scopariusin A and isoscoparin N. Org Lett. 2013;15:314-7 pubmed publisher
    ..0]undecane ring system, two new normal ent-halimanoids (4 and 5), and a new ent-clerodanoid (6) were isolated from Isodon scoparius...
  53. Xiang Z, Wang G, Huang L, Heng L, Li X. A new ent-kaurane diterpenoid glycoside from Isodon japonica var. glaucocalyx. J Asian Nat Prod Res. 2013;15:574-8 pubmed publisher
    ..1), named glaucocalyxin G, has been isolated from the n-butanol-soluble fraction of the dried whole plants of Isodon japonica var...
  54. He Z, Chen Z, Wang Y, Qiu P, Zhang J. [Chemical constituents of Isodon macrophyllus (II)]. Zhong Yao Cai. 2007;30:794-6 pubmed
    To study the chemical constituents of Isodon macrophyllus. Compounds were spearated and purified by silica gel column chromatography and their structures were elucidated on the basis of spectral data and chemical evidences...
  55. Zhao A, Han Q, Li R, Li S, Qing C, Zhang Y, et al. Diterpenoids from Isodon melissoides. J Nat Prod. 2004;67:1441-4 pubmed
    ..B (11), melissoidesin G (12), melissoidesin E (13), and dawoensin A (14), were isolated from the aerial parts of Isodon melissoides...
  56. Weng Z, Huang S, Li M, Zeng Y, Han Q, Rios J, et al. Isolation of two bioactive ent-kauranoids from the leaves of Isodon xerophilus. J Agric Food Chem. 2007;55:6039-43 pubmed
    b>Isodon xerophilus has been used as a herbal cold tea for the prevention and treatment of sore throat and inflammation in southernwestern China. A phytochemical study on the ethyl acetate (EtOAc) soluble fraction of I...
  57. Luo X, Pu J, Xiao W, Zhao Y, Gao X, Li X, et al. Cytotoxic ent-kaurane diterpenoids from Isodon rubescens var. lushiensis. J Nat Prod. 2010;73:1112-6 pubmed publisher
    ..diterpenoids, isolushinins A-J (1-10), together with 20 known compounds, were isolated from the aerial parts of Isodon rubescens var. lushiensis. The structures of 1-10 were elucidated by spectroscopic analysis...
  58. Liang Y, Xie H, Wu P, Jiang Y, Wei X. Podocarpane, isopimarane, and abietane diterpenoids from Isodon lophanthoides var. graciliflorus. Food Chem. 2013;136:1177-82 pubmed publisher
    ..acetal, graciliflorin C (3), and a rearranged abietane, graciliflorin D (4) were isolated from the aerial parts of Isodon lophanthoides var...
  59. Zhou Y, Huang S, Li L, Yang J, Liu X, Peng S, et al. Negative electrospray ionization tandem mass spectrometric investigation of ent-kaurane diterpenoids from the genus Isodon. J Mass Spectrom. 2008;43:63-73 pubmed
    ent-Kaurane diterpenoids are a class of natural compounds isolated from genus Isodon, which have been found to have important bioactivities...
  60. Du Y, Liu P, Shi X, Jin Y, Wang Q, Zhang X, et al. A novel analysis method for diterpenoids in rat plasma by liquid chromatography-electrospray ionization mass spectrometry. Anal Biochem. 2010;407:111-9 pubmed publisher
    ..The proposed method was further applied to investigate the pharmacokinetics of all analytes after a single oral administration of Isodon rubescens extract to rats.
  61. Li J, Chen Q, Jin Q, Gao J, Zhao P, Lu S, et al. IeCPS2 is potentially involved in the biosynthesis of pharmacologically active Isodon diterpenoids rather than gibberellin. Phytochemistry. 2012;76:32-9 pubmed publisher
    The traditional Chinese medicinal plant, Isodon L., is remarkably rich in pharmacologically active ent-kaurane diterpenoids of diverse carbon skeletons...
  62. Xia R, Chen S, Qin Q, Chen Y, Zhang W, Zhu R, et al. Oridonin Suppresses Proliferation of Human Ovarian Cancer Cells via Blockage of mTOR Signaling. Asian Pac J Cancer Prev. 2016;17:667-71 pubmed
    ..In summary, our results indicate that oridonin is a potential inhibitor of ovarian cancer by blocking the mTOR signaling pathway. ..
  63. Liu Y, Chia L, Ding J, Shen Y, Li R, Goh N, et al. Two new rearranged abietane diterpenoids from tropical Isodon coetsa. J Asian Nat Prod Res. 2006;8:671-5 pubmed
    ..new rearranged abietane diterpenoids, sincoetsin A (1) and sincoetsin B (2), were isolated from the aerial part of Isodon coetsa (Buth-Ham ex D...
  64. Zhang H, Pu J, Zhao Y, He F, Zhao W, Lou L, et al. Three new 18-oxygenated ent-kaurane diterpenoids from Isodon leucophyllus. Nat Prod Commun. 2010;5:1873-6 pubmed
    ..ent-kaurane diterpenoids, isoleuconins A-C (1-3) and ten known diterpenoids were isolated from the aerial parts of Isodon leucophyllus. The structures were elucidated by 1D and 2D NMR spectroscopic analysis...
  65. Hu Z, Zhan R, Du X, Su J, Li X, Yang J, et al. Cytotoxic ent-kaurane diterpenoids from Isodon henryi. Chem Pharm Bull (Tokyo). 2011;59:1562-6 pubmed
    ..diterpenoids, isodonhenrins A-E (1-5), together with thirteen known ones were isolated from the aerial parts of Isodon henryi...
  66. Kim J, Kim H, Kim Y, Lee H, Kim J, Kang J, et al. Effusanin C inhibits inflammatory responses via blocking NF-?B and MAPK signaling in monocytes. Int Immunopharmacol. 2013;15:84-8 pubmed publisher
    Effusanin C, a constituent of Isodon japonicus, has been used in oriental countries as a traditional folk medicine to treat inflammatory diseases, but its mechanism of action remains unknown...
  67. Jin Y, Tian T, Ma Y, Liu M, Xie W, Wang X, et al. Differentiation of Isodon japonica and Adulterants Based on Identification and Quantitation 14 Diterpenoids Using LC-MS-MS Library Search Approach and Hierarchical Cluster Analysis. J Chromatogr Sci. 2016;54:367-76 pubmed publisher
    The aim of this study was to investigate the chemical differences between genunine Isodon japonica and its adulterants...
  68. Ma Y, Su N, Zhao N, Li Q, Zhang M, Zhao H, et al. [Jaridonin, a new diterpenoid from Isodon rubescens, induces cell cycle arrest in gastric cancer cells through activating ataxia telangiectasia mutated kinase]. Zhonghua Zhong Liu Za Zhi. 2016;38:258-62 pubmed publisher
    To study the effects of Jaridonin, a novel diterpenoid from isodon rubescens, on the cell cycle of human gastric cancer cells and its molecular mechanism of action...
  69. Shin T, Kim S, Choi C, Shin H, Kim H. Isodon japonicus decreases immediate-type allergic reaction and tumor necrosis factor-alpha production. Int Arch Allergy Immunol. 2004;135:17-23 pubmed
    ..b>Isodon japonicus Hara (Labiatae) (IJAE) has been used for centuries as a traditional medicine in Korea and is known to ..
  70. Feng T, Pu J, Hu Z, Liu D, Sun H, Zhou G. [Rabdocoetsin B, a diterpenoid isolated from Isodon coetsa, is a potential proteasome inhibitor and induced apoptosis of t(8;21) leukemia cells]. Sheng Wu Gong Cheng Xue Bao. 2009;25:1218-24 pubmed
    Effects of Rabdocoetsin B (Rabd-B), a diterpenoid extracted from Isodon coetsa, on t(8;21) leukemic cells was tested by CCK-8 assay and Flow cytometry...
  71. Zou J, Pan L, Li Q, Zhao J, Pu J, Yao P, et al. Rubesanolides A and B: diterpenoids from Isodon rubescens. Org Lett. 2011;13:1406-9 pubmed publisher
    From the medicinal plant Isodon rubescens, we isolated two novel diterpenes, rubesanolides A (1) and B (2). The compounds contain a unique ?-lactone subgroup...
  72. Ohsaki A, Ozawa M, Komiyama K, Kishida A, Isobe T. The cytotoxic activity of diterpenoids from Isodon species. Nat Prod Commun. 2012;7:977-8 pubmed
    Fifteen Isodon diterpenoids (1-15) were evaluated for their cytotoxic activity against HeLa and HL-60 human cancer cell lines, and against murine vincristine (VCR)-resistant P388 cells...
  73. Yang J, Du X, He F, Zhang H, Li X, Su J, et al. Bioactive abietane and ent-kaurane diterpenoids from Isodon tenuifolius. J Nat Prod. 2013;76:256-64 pubmed publisher
    ..tenuifolins A-M (4-16), along with four known compounds (17-20), were isolated from the aerial parts of Isodon tenuifolius...
  74. Huang S, Pu J, Xiao W, Li L, Weng Z, Zhou Y, et al. ent-Abietane diterpenoids from Isodon rubescens var. rubescens. Phytochemistry. 2007;68:616-22 pubmed
    ..diterpenoids, hebeiabinins A-F (1-5), together with seven known diterpenoids were isolated from leaves of Isodon rubescens var. rubescens...
  75. Ding L, Qi L, Jing H, Li J, Wang W, Wang T. Phytotoxic effects of leukamenin E (an ent-kaurene diterpenoid) on root growth and root hair development in Lactuca sativa L. seedlings. J Chem Ecol. 2008;34:1492-500 pubmed publisher
    Leukamenin E, an ent-kaurene diterpenoid isolated from Isodon racemosa (Hemsl) Hara, showed phytotoxic effects on root growth and root hair development of lettuce seedlings (Lactuca sativa L.)...
  76. Jin Y, Du Y, Shi X, Liu P. Simultaneous quantification of 19 diterpenoids in Isodon amethystoides by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry. J Pharm Biomed Anal. 2010;53:403-11 pubmed publisher
    ..mass spectrometry (HPLC-ESI-MS/MS) method was developed to characterize and quantify 19 diterpenoid compounds in Isodon amethystoides simultaneously...
  77. Gao X, Luo X, Pu J, Wu Y, Zhao Y, Yang L, et al. Antiproliferative diterpenoids from the leaves of Isodon rubescens. Planta Med. 2011;77:169-74 pubmed publisher
    A phytochemical study of Isodon rubescens leaves led to the isolation of five new diterpenoids, isorubesins A-E ( 1- 5), and fifteen known diterpenoids. The structures of these new compounds were elucidated by spectroscopic evidence...
  78. Li X, Pu J, Du X, Lou L, Li L, Huang S, et al. Structure and cytotoxicity of diterpenoids from Isodon eriocalyx. J Nat Prod. 2010;73:1803-9 pubmed publisher
    ..8, 10-14) and 3?-acetoxy-maoesin A (9), together with 21 known compounds, were isolated from the aerial parts of Isodon eriocalyx. The structures of 1-14 were determined by spectroscopic data interpretation...
  79. Muchowicz A, Firczuk M, Chlebowska J, Nowis D, Stachura J, Barankiewicz J, et al. Adenanthin targets proteins involved in the regulation of disulphide bonds. Biochem Pharmacol. 2014;89:210-6 pubmed publisher
    ..This observation might be of importance in considering potential therapeutic applications of adenanthin to include a range of diseases, where aberrant activity of Prdx, Trx-TrxR and PDI is involved in their pathogenesis. ..
  80. Cheng C, Guo S, Chen J. [IR-fingerprinting ordination comparison on different organs of three species of isodon]. Guang Pu Xue Yu Guang Pu Fen Xi. 2002;22:954-8 pubmed
    The plants of the genus Isodon are of important medicinal values, being widely used in the production of the Chinese traditional and herbal drugs...
  81. Lee J, Choi J, Noh M, Hwang B, Hong Y, Lee J. Anti-inflammatory effect of kamebakaurin in in vivo animal models. Planta Med. 2004;70:526-30 pubmed
    ..Taken together, kamebakaurin, a specific inhibitor of DNA-binding activity of the p50 subunit, is a valuable candidate for the intervention in NF-KB-dependent pathological conditions such as inflammation...
  82. Huang L, Li C, Lu Z, Ma Z, Yu D. Total synthesis and biological evaluation of (+)- and (-)-Butyl ester of rosmarinic acid. J Asian Nat Prod Res. 2006;8:561-6 pubmed
    ..Their antioxidative and anti-tumor activities were evaluated...
  83. Hong S, Lee C, Lee C, Park M, Lee M, Hong J, et al. A new furofuran lignan from Isodon japonicus. Arch Pharm Res. 2009;32:501-4 pubmed publisher
    ..with two known flavonoids (2 and 3) and three phenolic compounds (4-6) were isolated from the aerial parts of Isodon japonicus...
  84. Gu Z, Wu Y, Zhou M, Liu C, Xu H, Yan H, et al. Pharicin B stabilizes retinoic acid receptor-? and presents synergistic differentiation induction with ATRA in myeloid leukemic cells. Blood. 2010;116:5289-97 pubmed publisher
    ..Here, we identify a novel natural ent-kaurene diterpenoid derived from Isodon pharicus leaves, called pharicin B, that can rapidly stabilize RAR-? protein in various acute myeloid leukemic (..
  85. Kondoh M, Suzuki I, Harada M, Nagashima F, Fujii M, Asakawa Y, et al. Activation of p38 mitogen-activated protein kinase during ent-11alpha-hydroxy-16-kauren-15-one-induced apoptosis in human leukemia HL-60 cells. Planta Med. 2005;71:275-7 pubmed
    ..Cleavage of Bid, a typical substrate of caspase-8, was also inhibited by treatment with SB203580, suggesting that activation of p38 (MAPK) occurs upstream of caspase-8 during KD-induced apoptosis...
  86. Na Z. [Study on the chemical constituents of the volatile oil from aerial parts of Isodon eriocalyx var. laxiflora]. Zhongguo Zhong Yao Za Zhi. 2005;30:1268-70 pubmed
    To study the chemical constituents of the volatile oil from the aerial parts of Isodon eriocalyx var. laxiflora.
  87. Krawczuk P, Schöne N, Baran P. A synthesis of the carbon skeleton of maoecrystal V. Org Lett. 2009;11:4774-6 pubmed publisher
    ..The key transformations include arylation of a 1,3-dicarbonyl compound with a triarylbismuth(V) dichloride species, oxidative dearomatization of a phenol, and a subsequent intramolecular Diels-Alder reaction...
  88. Zhao W, Pu J, Du X, Wu Y, Zhao Y, He F, et al. Chemical constituents from the aerial parts of Isodon coetsa and their cytotoxicity. Arch Pharm Res. 2011;34:2007-14 pubmed publisher
    ..and a diterpenoid, together with twenty known compounds (4-23), were isolated from the aerial parts of Isodon coetsa. Their structures and relative configurations were elucidated on the basis of spectroscopic data...
  89. Liu W, Fan B, Guo H, Yuan Y, Liang H, Bai S. Isolation and identification of a new ent-kaurane diterpenoid from the leaves of Isodon japonica. Nat Prod Res. 2013;27:1388-92 pubmed publisher
    ..14?, 16?-trihydroxy-ent-kaurane (1), together with seven known diterpenoids (2-8), was isolated from the leaves of Isodon japonica...
  90. Zeb A, Sadiq A, Ullah F, Ahmad S, Ayaz M. Phytochemical and toxicological investigations of crude methanolic extracts, subsequent fractions and crude saponins of Isodon rugosus. Biol Res. 2014;47:57 pubmed publisher
    b>Isodon rugosus is used traditionally in the management of hypertension, rheumatism, tooth-ache and pyrexia. Present study was arranged to investigate I...
  91. Zhao Y, Pu J, Huang S, Wu Y, Yang L, Xiao W, et al. ent-Kaurane diterpenoids from Isodon scoparius. J Nat Prod. 2009;72:125-9 pubmed publisher
    ..the acetonide of rabdoloxin A (10), along with 16 known analogues (11-26), were isolated from the leaves of Isodon scoparius. The new structures were determined by 1D and 2D NMR spectroscopic analysis...
  92. Du Y, Jin Y, Liu P, Zhang X, Sheng X, Shi X, et al. Rapid method for simultaneous determination of 20 components in Isodon nervosa by high-performance liquid chromatography-electrospray ionisation tandem mass spectrometry. Phytochem Anal. 2010;21:416-27 pubmed publisher
    b>Isodon nervosa is a commonly used traditional Chinese medicine including diterpenoids, phenolic acids, triterpenoids and volatile oil. Qualitative and quantitative analysis of multi-components is important for its quality control.