ajuga

Summary

Summary: A plant genus of the family LAMIACEAE that contains cyasterone, ajugasterone, 20-hydroxyecdysone, 8-acetylharpagide (an iridoid glycoside).

Top Publications

  1. Singh N, Mahmood U, Kaul V, Jirovetz L. A new phthalic acid ester from Ajuga bracteosa. Nat Prod Res. 2006;20:593-7 pubmed
    ..acid bis(2S-methyl heptyl) ester (1) was isolated from the hexane extract of the whole plant of Ajuga bracteosa...
  2. Makonnen E, Debella A, Abebe D, Teka F. Analgesic properties of some ethiopian medicinal plants in different models of nociception in mice. Phytother Res. 2003;17:1108-12 pubmed
    ..The plants subject for the present screening were Ocimum suave, Ocimum lamiifolium, Lippia adoensis, and Ajuga remota...
  3. Debella A, Makonnen E, Abebe D, Teka F, Kidanemariam A. Pain management in mice using the aqueous and ethanol extracts of four medicinal plants. East Afr Med J. 2003;80:435-9 pubmed
    ..There are many traditionally used analgesic plants in Ethiopia. They, however, have not been subject to scientific investigation for their efficacy and safety...
  4. El Hilaly J, Lyoussi B. Hypoglycaemic effect of the lyophilised aqueous extract of Ajuga iva in normal and streptozotocin diabetic rats. J Ethnopharmacol. 2002;80:109-13 pubmed
    ..of this study was to examine the hypoglycaemic effect of the lyophilised aqueous extract of the whole plant of Ajuga iva (L.) Schreber (Labiatae) in normal and streptozotocin-induced diabetic rats...
  5. Coll J. NMR shift data of neo-clerodane diterpenes from the genus Ajuga. Phytochem Anal. 2002;13:372-80 pubmed
    ..spectra of ajugarin I and ajugareptansin, as models for other neo-clerodane diterpenoids isolated from the genus Ajuga, is reported in order to improve their usefulness as reference compounds...
  6. Kumar G, Kanaujia N, Bafana A. Functional and phylogenetic diversity of root-associated bacteria of Ajuga bracteosa in Kangra valley. Microbiol Res. 2012;167:220-5 pubmed publisher
    Present study investigates the cultivable diversity of root-associated bacteria from a medicinal plant Ajuga bracteosa in the Kangra valley, in order to determine their plant growth promoting (PGP) and biotechnological potential...
  7. Manguro L, Ogur J, Okora D, Wagai S, Lemmen P. Further flavonol and iridoid glycosides from Ajuga remota aerial parts. J Asian Nat Prod Res. 2007;9:617-29 pubmed
    ..and isorhamnetin 3-O-rutinoside-7-O-rutinoside-4'-O-beta-glucoside (8) have been isolated from the aerial parts of Ajuga remota. Also isolated were two known compounds ajugarin IV and ajugarin V...
  8. Castro A, Coll J, Tandrón Y, Pant A, Mathela C. Phytoecdysteroids from Ajuga macrosperma var. breviflora roots. J Nat Prod. 2008;71:1294-6 pubmed publisher
    ..phytoecdysteroids, ajugacetalsterones C (1) and D (3) and breviflorasterone (2), were isolated from the roots of Ajuga macrosperma var...
  9. Chenni A, Yahia D, Boukortt F, Prost J, Lacaille Dubois M, Bouchenak M. Effect of aqueous extract of Ajuga iva supplementation on plasma lipid profile and tissue antioxidant status in rats fed a high-cholesterol diet. J Ethnopharmacol. 2007;109:207-13 pubmed
    ..present study was designed to explore the possible antioxidant and hypolipidemic effects of the aqueous extract of Ajuga iva (0.5% in the diet) in rats fed a high-cholesterol (1%) diet (HCD)...

More Information

Publications89

  1. Peters S, Keller F. Frost tolerance in excised leaves of the common bugle (Ajuga reptans L.) correlates positively with the concentrations of raffinose family oligosaccharides (RFOs). Plant Cell Environ. 2009;32:1099-107 pubmed publisher
    ..Our focus here was on the longer RFO members as they commonly occur in the frost-hardy evergreen labiate Ajuga reptans in its natural habitat, and accumulate to their highest concentrations in winter when the plant is faced ..
  2. El Hilaly J, Tahraoui A, Israili Z, Lyoussi B. Hypolipidemic effects of acute and sub-chronic administration of an aqueous extract of Ajuga iva L. whole plant in normal and diabetic rats. J Ethnopharmacol. 2006;105:441-8 pubmed
    ..The plant Ajuga iva (L.) Schreiber (Labiatea) is used in the treatment of diabetes in Moroccan folk medicine...
  3. El Hilaly J, Israili Z, Lyoussi B. Acute and chronic toxicological studies of Ajuga iva in experimental animals. J Ethnopharmacol. 2004;91:43-50 pubmed
    b>Ajuga iva (L.) Schreber (AI), is widely used in the Moroccan pharmacopoeia as a panacea (cure-all), and specifically for gastrointestinal disorders and diabetes, and as an anthelmintic...
  4. Bouderbala S, Lamri Senhadji M, Prost J, Lacaille Dubois M, Bouchenak M. Changes in antioxidant defense status in hypercholesterolemic rats treated with Ajuga iva. Phytomedicine. 2008;15:453-61 pubmed
    The aim of the study was to investigate the effect of aqueous extract of Ajuga iva (Ai) on serum and tissues lipid peroxidation as well as antioxidant enzymes activities in red blood cells (RBC) and tissues, in high hypercholesterolemic ..
  5. Hamden K, Ayadi F, Jamoussi K, Masmoudi H, Elfeki A. Therapeutic effect of phytoecdysteroids rich extract from Ajuga iva on alloxan induced diabetic rats liver, kidney and pancreas. Biofactors. 2008;33:165-75 pubmed
    In the current study, the effect of Ajuga iva extract on blood glucose, lipid profile, hepatic and renal toxicity and antioxidant enzyme activities in alloxan-induced diabetic rats was investigated...
  6. Di Paola R, Esposito E, Mazzon E, Riccardi L, Caminiti R, Dal Toso R, et al. Teupolioside, a phenylpropanoid glycosides of Ajuga reptans, biotechnologically produced by IRBN22 plant cell line, exerts beneficial effects on a rodent model of colitis. Biochem Pharmacol. 2009;77:845-57 pubmed publisher
    ..study was to examine the effects of phenylpropanoid glycoside, teupolioside, biotechnologically produced by IRBN22 Ajuga reptans cell line, in rats subjected to experimental colitis...
  7. Gautam R, Jachak S, Saklani A. Anti-inflammatory effect of Ajuga bracteosa Wall Ex Benth. mediated through cyclooxygenase (COX) inhibition. J Ethnopharmacol. 2011;133:928-30 pubmed publisher
    b>Ajuga bracteosa Wall Ex Benth. (Labiateae) is described in Ayurveda for the treatment of rheumatism, gout, palsy and amenorrhea.
  8. Hsieh W, Liu Y, Lin W. Anti-inflammatory properties of Ajuga bracteosa in vivo and in vitro study and their effects on mouse model of liver fibrosis. J Ethnopharmacol. 2011;135:116-25 pubmed publisher
    The entire plant of Ajuga bracteosa Wall has been used to treat various inflammatory disorders, including hepatitis, in Taiwan.
  9. Ványolós A, Simon A, Toth G, Polgar L, Kele Z, Ilku A, et al. C-29 ecdysteroids from Ajuga reptans var. reptans. J Nat Prod. 2009;72:929-32 pubmed publisher
    Investigation of the ecdysteroid constituents of the herb Ajuga reptans var...
  10. Israili Z, Lyoussi B. Ethnopharmacology of the plants of genus Ajuga. Pak J Pharm Sci. 2009;22:425-62 pubmed
    The plants of genus Ajuga are evergreen, clump-forming rhizomatous perennial or annual herbaceous flowering species, with Ajuga being one of the 266 genera of the family Lamiaceae...
  11. Chandel S, Bagai U. Antiplasmodial activity of Ajuga bracteosa against Plasmodium berghei infected BALB/c mice. Indian J Med Res. 2010;131:440-4 pubmed
    ..work was undertaken to evaluate antiplasmodial activity of ethanolic leaves extract of traditional medicinal plant Ajuga bracteosa in Plasmodium berghei infected BALB/c mice along with its phytochemical screening and acute toxicity ..
  12. Chiou C, Kuo Y, Chan Y, Juang S, Chan H, Wu T. Ajugalide-B (ATMA) is an anoikis-inducing agent from Ajuga taiwanensis with antiproliferative activity against tumor cells in vitro. Phytochemistry. 2012;80:64-9 pubmed publisher
    b>Ajuga taiwanensis is widely used for the treatment of hepatitis and hepatoma in Taiwanese folk medicine. However, its bioactive components and mechanism of action are unclear...
  13. Ono Y, Fukaya Y, Imai S, Yamakuni T. Beneficial effects of Ajuga decumbens on osteoporosis and arthritis. Biol Pharm Bull. 2008;31:1199-204 pubmed
    Extract of the whole plant, Ajuga decumbens (KE) has long been used in China as a medication for the relief of joint pain. Previously, we proved that KE up-regulated the synthesis of collagen in false aged model rats...
  14. El Hilaly J, Tahraoui A, Israili Z, Lyoussi B. Acute hypoglycemic, hypocholesterolemic and hypotriglyceridemic effects of continuous intravenous infusion of a lyophilised aqueous extract of Ajuga iva L. Schreber whole plant in streptozotocin-induced diabetic rats. Pak J Pharm Sci. 2007;20:261-8 pubmed
    ..and hypolipidemic effect of continuous intravenous infusion of a lyophilised aqueous extract of the whole plant Ajuga iva (L...
  15. Chan Y. Neoclerodane diterpenoids from Ajuga taiwanensis. Chem Pharm Bull (Tokyo). 2005;53:164-7 pubmed
    Phytochemical investigation of Ajuga taiwanensis resulted in the isolation of seven neoclerodane diterpenes, four of which ajugalide-A (1), -B (2), -C (3), and -D (4), are new and the remaining three are known diterpenes, ajugamacrin B (..
  16. Asnake S, Teklehaymanot T, Hymete A, Erko B, Giday M. Evaluation of the antiplasmodial properties of selected plants in southern Ethiopia. BMC Complement Altern Med. 2015;15:448 pubmed publisher
    ..Thus, the aim of this study was to evaluate the safety and antimalarial activity of extracts of Ajuga integrifolia, Clerodendrum myricoides, Melia azedarach, Peponium vogelii and Premna schimperi, locally used by the ..
  17. Nardos A, Makonnen E. In vivo antiplasmodial activity and toxicological assessment of hydroethanolic crude extract of Ajuga remota. Malar J. 2017;16:25 pubmed publisher
    ..This study aimed at investigating the in vivo antiplasmodial activity of crude extract of the leaves of Ajuga remota together with its safety in mice models...
  18. Lin Y, Lin C, Wang H, Hsu Y. Induction of Mitotic Delay in Pharyngeal and Nasopharyngeal Carcinoma Cells Using an Aqueous Extract of Ajuga bracteosa. Int J Med Sci. 2017;14:462-469 pubmed publisher
    ..to have potential uses in chemotherapy; however, the mechanisms underlying the observed antitumor activity of Ajuga bracteosa (AB) against NPC remain unclear...
  19. Verma V, Mahmood U, Singh B. Clerodane diterpenoids from Ajuga bracteosa Wall. Nat Prod Lett. 2002;16:255-9 pubmed
    The whole plant of Ajuga bracteosa afforded five compounds including one new clerodane diterpenoid designated as Bracteonin-A (1) 6alpha-acetoxy, 15 (R&S)-methoxy, 18-(4'-hydroxy, 3'-beta-methyl, 3'-alpha-acetoxy, butyryloxy) ..
  20. Thakur M, Asrani R, Thakur S, Sharma P, Patil R, Lal B, et al. Observations on traditional usage of ethnomedicinal plants in humans and animals of Kangra and Chamba districts of Himachal Pradesh in North-Western Himalaya, India. J Ethnopharmacol. 2016;191:280-300 pubmed publisher
    ..b>Ajuga parviflora, Berberis lycium, Viola canescens, Vitex negundo and Zanthoxylum armatum were the most important ..
  21. Yildirim A, Karakaş F, Turker A. In vitro antibacterial and antitumor activities of some medicinal plant extracts, growing in Turkey. Asian Pac J Trop Med. 2013;6:616-24 pubmed publisher
    ..different extracts prepared with 3 types of solvents (water, ethanol and methanol) of 16 different plant species (Ajuga reptans (A. reptans) L., Phlomis pungens (P. pungens) Willd., Marrubium astracanicum (M. astracanicum) Jacq...
  22. Hsieh C, Ko W, Ho W, Chang C, Chen G, Tsai J. Antioxidant and hepatoprotective effects of Ajuga nipponensis extract by ultrasonic-assisted extraction. Asian Pac J Trop Med. 2016;9:420-5 pubmed publisher
    To investigate suitable condition for extraction of the active components from Ajuga nipponensis (A. nipponensis). Orthogonal experimental design was used to determine the optimal extraction parameters for ecdysterones and flavonoids...
  23. Pastore S, Potapovich A, Kostyuk V, Mariani V, Lulli D, De Luca C, et al. Plant polyphenols effectively protect HaCaT cells from ultraviolet C-triggered necrosis and suppress inflammatory chemokine expression. Ann N Y Acad Sci. 2009;1171:305-13 pubmed publisher
    ..Verbascoside and teupolioside are hence of potential interest in the protection of the skin from both environmental and inflammatory insults...
  24. Kayani W, Dilshad E, Ahmed T, Ismail H, Mirza B. Evaluation of Ajuga bracteosa for antioxidant, anti-inflammatory, analgesic, antidepressant and anticoagulant activities. BMC Complement Altern Med. 2016;16:375 pubmed
    b>Ajuga bracteosa has been extensively used traditionally for the treatment of a variety of diseases. The aim of the study was to scientifically validate the wide-scale exploitation of A...
  25. Tsukagoshi Y, Ohyama K, Seki H, Akashi T, Muranaka T, Suzuki H, et al. Functional characterization of CYP71D443, a cytochrome P450 catalyzing C-22 hydroxylation in the 20-hydroxyecdysone biosynthesis of Ajuga hairy roots. Phytochemistry. 2016;127:23-8 pubmed publisher
    ..proposed involvement of 3?-hydroxy-5?-cholestan-6-one (5?-ketone) in 20HE biosynthesis in the hairy roots of Ajuga reptans var. atropurpurea (Lamiaceae)...
  26. Yousaf T, Rafique S, Wahid F, Rehman S, Nazir A, Rafique J, et al. Phytochemical profiling and antiviral activity of Ajuga bracteosa, Ajuga parviflora, Berberis lycium and Citrus lemon against Hepatitis C Virus. Microb Pathog. 2018;118:154-158 pubmed publisher
    ..this study was designed to find out phytochemicals and investigate antiviral activity of methanol extract of Ajuga bracteosa, Ajuga parviflora, Berberis lycium and Citrus lemon against Hepatitis C Virus (HCV infection)...
  27. Goren A, Zhou B, Topcu G, Kökdil G, Kingston D. DNA damaging activities of methanol extract of Ajuga postii and iridoid glucoside reptoside. Nat Prod Res. 2005;19:457-60 pubmed
    ..1) has been isolated as a DNA damaging active agent by bioassay-guided fractionation of the methanol extract of Ajuga postii. Furthermore, from the acetone extract of A...
  28. Yacob T, Shibeshi W, Nedi T. Antidiarrheal activity of 80 % methanol extract of the aerial part of Ajuga remota Benth (Lamiaceae) in mice. BMC Complement Altern Med. 2016;16:303 pubmed publisher
    In the Ethiopian traditional medicine, the aerial part of Ajuga remota Benth is used in the treatment of diarrhea. There are different mechanisms by which Ajuga remota may have antidiarrheal effect...
  29. Ganaie H, Ali M, Ganai B, Meraj M, Ahmad M. Antibacterial activity of 14, 15-dihydroajugapitin and 8-o-acetylharpagide isolated from Ajuga bracteosa Wall ex. Benth against human pathogenic bacteria. Microb Pathog. 2017;103:114-118 pubmed publisher
    b>Ajuga bracteosa Wall ex. Benth. (Lamiaceae) commonly known as Bungle Weed has been in use since ancient times and is mentioned Ayurvedic literature. The upper ground parts of the plant are used for treatment of various diseases...
  30. Samaniego Castruita J, Zepeda Mendoza M, Barnett R, Wales N, Gilbert M. Odintifier--A computational method for identifying insertions of organellar origin from modern and ancient high-throughput sequencing data based on haplotype phasing. BMC Bioinformatics. 2015;16:232 pubmed publisher
    ..leo) to characterize insertions from mitochondrial origin, and from common grapevine (Vitis vinifera) and bugle (Ajuga reptans) to characterize insertions derived from plastid genomes...
  31. Khanavi M, Najafi B, Sadati S, Abai M, Vatandoost H. Chemical Constitute and Larvicidal Activity of Fractions of Ajuga chamaecistus tomentella Plant against Malaria Vector Anopheles stephensi. J Arthropod Borne Dis. 2017;11:116-123 pubmed
    The genus Ajuga, belongs to Lamiaceae family, is one of the exclusive subspecies in the flora of Iran. The plants of this genus are used traditionally for treatment of joints pain, gout, jaundice, and as insecticide.
  32. Wen B, Li J. [Pharmacokinetics of 8-O-acetylharpagide and harpagide after oral administration of Ajuga decumbens extract in beagle dog]. Zhongguo Zhong Yao Za Zhi. 2013;38:2015-8 pubmed
    8-O-acetylharpagide and harpagide are two kinds of effective component of Ajuga decumbens extract...
  33. Tafesse T, Hymete A, Mekonnen Y, Tadesse M. Antidiabetic activity and phytochemical screening of extracts of the leaves of Ajuga remota Benth on alloxan-induced diabetic mice. BMC Complement Altern Med. 2017;17:243 pubmed publisher
    b>Ajuga remota Benth is traditionally used in Ethiopia for the management of diabetes mellitus...
  34. Peng B, He R, Xu Q, Gao J, Lu Y, Li J. [Correlation between antimetastatic action of Ajuga decumbens and expression of MMPs and TIMPs]. Zhongguo Zhong Yao Za Zhi. 2011;36:3511-4 pubmed
    To investigate the anticancer and anti-metastatic effect of Ajuga decumbens extraction (HBG) on breast cancer and to clarify the effect of HBG on MMPs and TIMPs...
  35. Sawada Y, Sugimoto A, Hananouchi T, Sato N, Nagaoka I. Evaluation of the efficacy of Ajuga decumbens extract supplement in individuals with knee discomfort associated with physical activity: A randomized, double-blind, placebo-controlled study. Exp Ther Med. 2017;14:4561-4571 pubmed publisher
    The aim of the present study was to assess the efficacy and safety of the oral administration of Ajuga decumbens extract (ADE) supplement to individuals with knee discomfort associated with physical activity...
  36. Hamden K, Carreau S, Jamoussi K, Ayadi F, Garmazi F, Mezgenni N, et al. Inhibitory effects of 1alpha, 25dihydroxyvitamin D3 and Ajuga iva extract on oxidative stress, toxicity and hypo-fertility in diabetic rat testes. J Physiol Biochem. 2008;64:231-9 pubmed
    ..Thus diabetic rats were treated with 1alpha, 25dihydroxyvitaminD3 or Ajuga iva extract as both therapeutic and preventive treatments on diabetes toxicity in rats testes...
  37. Liu Y, Fan Q. [Pharmacognostical studies on Prunella vulgaris and Ajuga decumbens]. Zhong Yao Cai. 2007;30:1230-4 pubmed
    b>Ajuga decumbens Thunb. is superficially similar to Prunella vulgaris Linn. and has been used as a substitution of the latter for along time. Systematical studies on external and internal structure were carried out on the two species...
  38. Fekete G, Polgár l, Bathori M, Col J, Darvas B. Per os efficacy of Ajuga extracts against sucking insects. Pest Manag Sci. 2004;60:1099-104 pubmed
    We studied the efficacy of water-soluble extracts from four Ajuga spp on the post-embryonic development of two exopterygota (sucking insect) species...
  39. Yue D, Ding G, Wang W, Wang Z, Li J, Tong Y. [Determination of acetylharpagide in Ajuga decumbens by HPLC]. Zhongguo Zhong Yao Za Zhi. 2006;31:289-90 pubmed
    To establish a method of the quantitative determination of acetylharpagide in Ajuga decumbens...
  40. Cocquyt K, Cos P, Herdewijn P, Maes L, Van den Steen P, Laekeman G. Ajuga remota Benth.: from ethnopharmacology to phytomedical perspective in the treatment of malaria. Phytomedicine. 2011;18:1229-37 pubmed publisher
    ..The genus of Ajuga belongs to the family Lamiaceae and contains at least 301 species...
  41. Ushid K, Maekawa M, Arakawa T. Influence of dietary supplementation of herb extracts on volatile sulfur production in pig large intestine. J Nutr Sci Vitaminol (Tokyo). 2002;48:18-23 pubmed
    ..The extracts Perilla frutescens (Soyou), Mentha piperita (Peppermint), and Ajuga decumbens (Kiransou) were fed to pigs equipped with a permanent cannula at the cecum...
  42. Rahman N, Ahmad M, Riaz M, Mehjabeen -, Jahan N, Ahmad R. Phytochemical, antimicrobial, insecticidal and brine shrimp lethality bioassay of the crude methanolic extract of Ajuga parviflora Benth. Pak J Pharm Sci. 2013;26:751-6 pubmed
    Methanolic extract of medicinal herb Ajuga parviflora Benth...
  43. Guo P, Li Y, Xu J, Liu C, Ma Y, Guo Y. Bioactive neo-clerodane diterpenoids from the whole plants of Ajuga ciliata Bunge. J Nat Prod. 2011;74:1575-83 pubmed publisher
    ..ajugaciliatins A-J (1-5, 8-12), along with 17 known analogues (6, 7, 13-27) were isolated from the whole plants of Ajuga ciliata Bunge...
  44. Chan Y, Wu T, Kuoh C, Damu A. A new phytoecdysteroid from Ajuga taiwanensis. Chem Pharm Bull (Tokyo). 2005;53:836-8 pubmed
    A new phytoecdysteroid, namely ajugalide-E (1), together with twenty five known compounds were isolated from Ajuga taiwanensis collected from Tainan, Taiwan...
  45. Tapernoux Lüthi E, Bohm A, Keller F. Cloning, functional expression, and characterization of the raffinose oligosaccharide chain elongation enzyme, galactan:galactan galactosyltransferase, from common bugle leaves. Plant Physiol. 2004;134:1377-87 pubmed
    ..Here, we report the cloning and functional expression of a cDNA encoding GGT from leaves of the common bugle (Ajuga reptans), a winter-hardy long-chain RFO-storing Lamiaceae. The cDNA comprises an open reading frame of 1215 bp...
  46. Manguro L, Wagai S, Lemmen P. Flavonol and iridoid glycosides of Ajuga remota aerial parts. Phytochemistry. 2006;67:830-7 pubmed
    ..and 6,8-diacetylharpagide-1-O-beta-(3',4'-di-O-acetylglucoside) have been isolated from extract of Ajuga remota aerial parts...
  47. Li J, Wu L, Zhang G. [Improvement effects of Jincao tablet on immune function of model of hysteromyoma in rats]. Zhongguo Zhong Yao Za Zhi. 2007;32:2277-81 pubmed
    ..To investigate the improvement effects of Jincao tablet on immune function of the model of hysteromyoma in rat and the relationship between the model and pathogenesis...
  48. Coll J, Tandrón Y, Zeng X. New phytoecdysteroids from cultured plants of Ajuga nipponensis Makino. Steroids. 2007;72:270-7 pubmed
    An extract from aerial parts of Ajuga nipponensis Makino was examined by high performance liquid chromatography for minor ecdysteroids...
  49. Dumas M, Gondran C, Barre P, Sougrat R, Verbavatz J, Heusele C, et al. Effect of an Ajuga turkestanica extract on aquaporin 3 expression, water flux, differentiation and barrier parameters of the human epidermis. Eur J Dermatol. 2002;12:XXV-XXVI pubmed
  50. Gitua J, Muchiri D, Nguyen X. In vivo antimalarial activity of Ajuga remota water extracts against Plasmodium berghei in mice. Southeast Asian J Trop Med Public Health. 2012;43:545-8 pubmed
    We investigated the in vivo activity of crude water extracts of Ajuga remota Benth (Labiatae) against Plasmodium berghei in mice using plants harvested from two areas in Kenya where the plant is commonly used to treat malaria...
  51. Riaz N, Nawaz S, Mukhtar N, Malik A, Afza N, Ali S, et al. Isolation and enzyme-inhibition studies of the chemical constituents from Ajuga bracteosa. Chem Biodivers. 2007;4:72-83 pubmed
    ..acid; 3), a long-chain polyhydroxy acid, were isolated from the whole plant Ajuga bracteosa along with four known diterpenoids 4-7...
  52. Hussain J, Begum N, Hussain H, Khan F, Rehman N, Al Harrasi A, et al. Ajuganane: a new phenolic compound from Ajuga bracteosa. Nat Prod Commun. 2012;7:615-6 pubmed
    Phytochemical investigation of Ajuga bracteosa Wall ex Benth...
  53. Venditti A, Frezza C, Riccardelli M, Foddai S, Nicoletti M, Serafini M, et al. Unusual molecular pattern in Ajugoideae subfamily: the case of Ajuga genevensis L. from Dolomites. Nat Prod Res. 2016;30:1098-102 pubmed publisher
    We analysed the ethanolic extract from Ajuga genevensis L. (Lamiaceae) growing in Dolomites, part of Italian Alps...
  54. Wen B, He R, Li P, Xu Q, Lu Y, Peng B, et al. Pharmacokinetics of 8-O-acetylharpagide and harpagide after oral administration of Ajuga decumbens Thunb extract in rats. J Ethnopharmacol. 2013;147:503-8 pubmed publisher
    b>Ajuga decumbens Thunb is a medicinal plant native to China popularly used to treat chronic pelvic inflammation and hysteromyoma...
  55. Sadati N, Jenett Siems K, Siems K, Ardekani M, Hadjiakhoondi A, Akbarzadeh T, et al. Major constituents and cytotoxic effects of Ajuga chamaecistus ssp. tomentella. Z Naturforsch C. 2012;67:275-81 pubmed
    The n-butanolic fraction of a methanolic extract (80%) from aerial parts of Ajuga chamaecistus ssp. tomentella was analysed using different chromatographic methods...
  56. Akbay P, Calis I, Heilmann J, Sticher O. New stigmastane sterols from Ajuga salicifolia. J Nat Prod. 2003;66:461-5 pubmed
    ..three new sterol glycosides, ajugasaliciosides F-H (2-4), were isolated and characterized from the aerial parts of Ajuga salicifolia. Compounds 1-4 are further representatives of the stigmastane type of sterols...
  57. Taleb Senouci D, Lacaille Dubois M, Bouchenak M. Ajuga iva aqueous extract improves reverse cholesterol transport in streptozotocin-induced diabetic rat. J Pharm Pharmacol. 2012;64:1188-94 pubmed publisher
    The aim of this study was to determine the effects of Ajuga iva aqueous extract on lecithin : cholesterol acyltransferase (LCAT) activity and amount and composition of high-density lipoprotein (HDL)(2) and (HDL)(3), in streptozotocin (..
  58. Schneider T, Keller F. Raffinose in chloroplasts is synthesized in the cytosol and transported across the chloroplast envelope. Plant Cell Physiol. 2009;50:2174-82 pubmed publisher
    ..protoplasts that raffinose is clearly (to about 20%) present in chloroplasts of cold-treated common bugle (Ajuga reptans L.), spinach (Spinacia oleracea L.) and Arabidopsis [Arabidopsis thaliana (L.) Heynh.] plants...
  59. Tapernoux Lüthi E, Schneider T, Keller F. The C-terminal sequence from common bugle leaf galactan:galactan galactosyltransferase is a non-sequence-specific vacuolar sorting determinant. FEBS Lett. 2007;581:1811-8 pubmed
    The Ajuga reptans L. galactan:galactan galactosyltransferase (ArGGT) is a vacuolar enzyme that synthesizes long-chain raffinose family oligosaccharides (RFOs), the major storage carbohydrates of this plant...
  60. Coll J, Tandrón Y. Isolation and identification of neo-clerodane diterpenes from Ajuga remota by high-performance liquid chromatography. Phytochem Anal. 2005;16:61-7 pubmed
    ..HPLC for the rapid isolation, identification and semi-preparative fractionation of neo-clerodane diterpenes from Ajuga remota, an extract from aerial parts of the plant was examined using a C18 column with UV detection and gradient ..
  61. Ono M, Furusawa C, Ozono T, Oda K, Yasuda S, Okawa M, et al. Four new iridoid glucosides from Ajuga reptans. Chem Pharm Bull (Tokyo). 2011;59:1065-8 pubmed
    Four new iridoid glucosides were isolated from the whole plant of Ajuga reptans L. (Labiatae) along with four known iridoid glucosides, one known diterpenoid glycoside, one known aliphatic alcohol glycoside, and three known ecdysteroids...
  62. Bouderbala S, Prost J, Lacaille Dubois M, Bouchenak M. Iridoid extracts from Ajuga iva increase the antioxidant enzyme activities in red blood cells of rats fed a cholesterol-rich diet. Nutr Res. 2010;30:358-65 pubmed publisher
    The lyophilized aqueous extract of Ajuga iva (Ai) is able to reduce oxidative stress, which may prevent lipid peroxidation in hypercholesterolemic rats. Iridoids (I) were isolated from Ai...
  63. Aly R, Ravid U, Abu Nassar J, Botnick I, Lebedev G, Gal S, et al. Biological activity of natural phytoecdysteroids from Ajuga iva against the sweetpotato whitefly Bemisia tabaci and the persea mite Oligonychus perseae. Pest Manag Sci. 2011;67:1493-8 pubmed publisher
    ..Many representatives of the genus Ajuga plants contain phytoecdysteroids with a 5?-7-ene-6-one system exhibiting physiological activities in insects.
  64. Dumas M, Sadick N, Noblesse E, Juan M, Lachmann Weber N, Boury Jamot M, et al. Hydrating skin by stimulating biosynthesis of aquaporins. J Drugs Dermatol. 2007;6:s20-4 pubmed
    ..We selected an ethanolic/water (70/30 v/v) extract of Ajuga turkestanica, a plant from Central Asia, as the hydrating agent...
  65. Korkina L, Mikhal chik E, Suprun M, Pastore S, Dal Toso R. Molecular mechanisms underlying wound healing and anti-inflammatory properties of naturally occurring biotechnologically produced phenylpropanoid glycosides. Cell Mol Biol (Noisy-le-grand). 2007;53:84-91 pubmed
    ..glycosides, verbascoside (VB) and teupolioside (TP), produced biotechnologically by Syringa vulgaris and Ajuga reptans plant cell cultures, were studied in vitro and in vivo for their anti-inflammatory and wound healing ..
  66. Alekseeva L. [Ecdysone 20-monooxygenase activity of cytochrome P450 in plants and cell culture of Ajuga reptans L]. Prikl Biokhim Mikrobiol. 2004;40:159-64 pubmed
    ..of cytochrome P450 and ecdysone 20-monooxygenase activity in plants and callus cell culture of the bugleweed Ajuga reptans L. were determined...
  67. Sun Z, Li Y, Jin D, Guo P, Song H, Xu J, et al. neo-Clerodane diterpenes from Ajuga decumbens and their inhibitory activities on LPS-induced NO production. Fitoterapia. 2012;83:1409-14 pubmed publisher
    A phytochemical investigation of the whole plants of Ajuga decumbens led to the isolation of three new (1, 2a, and 2b) and three known (3a-3c) neo-clerodane diterpenes...
  68. Guo P, Li Y, Xu J, Guo Y, Jin D, Gao J, et al. neo-Clerodane diterpenes from Ajuga ciliata Bunge and their neuroprotective activities. Fitoterapia. 2011;82:1123-7 pubmed publisher
    Three new (1-3) and three known (4-6) neo-clerodane diterpenes have been isolated from the whole plants of Ajuga ciliata Bunge...
  69. Castro A, Coll J, Arfan M. neo-Clerodane diterpenoids from Ajuga bracteosa. J Nat Prod. 2011;74:1036-41 pubmed publisher
    Different neo-clerodane diterpenoids were isolated from a dichloromethane extract of Ajuga bracteosa depending on the isolation procedure used, owing to the labile nature of these tetrahydrofurofuran derivatives...
  70. Venditti A, Frezza C, Maggi F, Lupidi G, Bramucci M, Quassinti L, et al. Phytochemistry, micromorphology and bioactivities of Ajuga chamaepitys (L.) Schreb. (Lamiaceae, Ajugoideae): Two new harpagide derivatives and an unusual iridoid glycosides pattern. Fitoterapia. 2016;113:35-43 pubmed publisher
    b>Ajuga chamaepitys (L.) Schreb, well-known as Camaepitium or Ground Pine, is an annual herb typical of the Mediterranean area accounting several uses in the traditional medicine...
  71. Riaz N, Malik A, Nawaz S, Muhammad P, Choudhary M. Cholinesterase-inhibiting withanolides from Ajuga bracteosa. Chem Biodivers. 2004;1:1289-95 pubmed
    ..3), have been isolated from the whole plants of Ajuga bracteosa. Their structures were deduced by spectral analysis, including 1D- and 2D-NMR techniques...
  72. Sajjadi S, Ghannadi A. Volatile oil composition of the aerial parts of Ajuga orientalis L. from Iran. Z Naturforsch C. 2004;59:166-8 pubmed
    The volatile oil content and composition of the aerial parts of Ajuga orientalis L. (Lamiaceae) grown in northern parts of Iran have been analyzed by GC/MS. Thirty compounds were identified, representing 97.9% of the total oil...
  73. Sun Z, Li Y, Jin D, Guo P, Xu J, Guo Y, et al. Structure elucidation and inhibitory effects on NO production of clerodane diterpenes from Ajuga decumbens. Planta Med. 2012;78:1579-93 pubmed
    ..clerodane diterpenes (1-3), together with five known analogues (4-8), have been isolated from the whole plants of Ajuga decumbens...
  74. Rharrabe K, Sayan F, Lafont R. Dietary effects of four phytoecdysteroids on growth and development of the Indian meal moth, Plodia interpunctella. J Insect Sci. 2010;10:13 pubmed publisher
    Using pure phytoecdysteroids isolated from Ajuga iva (L.) Schreber (Lamiales: Lamiaceae) and Silene nutans L...
  75. Zahra S, Ahmed M, Qasim M, Gul B, Zia M, Mirza B, et al. Polarity based characterization of biologically active extracts of Ajuga bracteosa Wall. ex Benth. and RP-HPLC analysis. BMC Complement Altern Med. 2017;17:443 pubmed publisher
    ..Therefore, the ameliorative characteristics of Ajuga bracteosa were studied...
  76. Chandel S, Bagai U. Screening of antiplasmodial efficacy of Ajuga bracteosa Wall ex. Benth. Parasitol Res. 2011;108:801-5 pubmed publisher
    ..In the present study, the traditional medicinal plant Ajuga bracteosa has been screened for its antiplasmodial efficacy...
  77. El Hilaly J, Lyoussi B, Wibo M, Morel N. Vasorelaxant effect of the aqueous extract of Ajuga iva in rat aorta. J Ethnopharmacol. 2004;93:69-74 pubmed
    ..The aim of the present study was to investigate the ex vivo and in vitro vascular activity of the aqueous extract of Ajuga iva (L.) Schreber (Labiatae) in normotensive Wistar rats...
  78. Qian J, Yang Y, Li X, Chi D. 20-hydroxyecdysone accumulation and regulation in Ajuga lobata D. Don suspension culture. Biosci Biotechnol Biochem. 2016;80:591-9 pubmed publisher
    Suspension culture of Ajuga lobata D. Don cells provides a method of synthesis of the phytoecdysteroid 20-hydroxyecdysone (20E) which can regulate the molting process of larvae...
  79. Ben Jannet H, Chaari A, Bakhrouf A, Mighri Z. Structure-antibacterial activity relationship of secondary metabolites from Ajuga pseudoiva Rob. leaves. Nat Prod Res. 2006;20:299-304 pubmed
    ..glycerides, clerodane diterpenoids, and a beta-hydroxy fatty acid methyl ester, all previously isolated from Ajuga pseudoiva leaves, were tested for their antibacterial activity toward three Gram- rods and one Gram+ coccus using ..
  80. Liao S, Chiu T, Chen J, Lin C. Ajuga nipponensis Makino poisoning. Clin Toxicol (Phila). 2005;43:583-5 pubmed
    A 58-year-old man ingested an herbal preparation of Ajuga nipponesis Makino, as recommended in folk medicine for the treatment of hepatoma...