tabebuia

Summary

Summary: A plant genus of the family BIGNONIACEAE that is a source of lapachol and beta-lapachone.

Top Publications

  1. Pereira I, Burci L, da Silva L, Baggio C, Heller M, Micke G, et al. Antiulcer effect of bark extract of Tabebuia avellanedae: activation of cell proliferation in gastric mucosa during the healing process. Phytother Res. 2013;27:1067-73 pubmed publisher
    b>Tabebuia avellanedae (syn. Handroanthus impetiginosus) is popularly known as 'ipê-roxo' and has been used in folk medicine as anti-inflammatory and in the treatment of ulcers, bacterial and fungal infections...
  2. Coelho J, Antoniolli A, Nunes e Silva D, Carvalho T, Pontes E, Odashiro A. [Effects of silver sulfadiazine, ipê roxo (tabebuia avellanedae) extract and barbatimão (stryphnodendron adstringens) extract on cutaneous wound healing in rats]. Rev Col Bras Cir. 2010;37:45-51 pubmed
    Morphological study of effects of silver sulfadiazine, Tabebuia avellanedae (ipê-roxo) extract and Stryphnodendron adstringens (barbatimão) extract on cutaneous wound healing was done.
  3. Freitas A, Budni J, Lobato K, Binfaré R, Machado D, Jacinto J, et al. Antidepressant-like action of the ethanolic extract from Tabebuia avellanedae in mice: evidence for the involvement of the monoaminergic system. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34:335-43 pubmed publisher
    The antidepressant-like effect of the ethanolic extract obtained from barks of Tabebuia avellanedae, a plant widely employed in folk medicine, was investigated in two predictive models of depression: forced swimming test (FST) and tail ..
  4. Warashina T, Nagatani Y, Noro T. Constituents from the bark of Tabebuia impetiginosa. Phytochemistry. 2004;65:2003-11 pubmed
    The bark of Tabebuia impetiginosa afforded nineteen glycosides, consisting of four iridoid glycosides, two lignan glycosides, two isocoumarin glycosides, three phenylethanoid glycosides and eight phenolic glycosides...
  5. Algranti E, Mendonça E, Ali S, Kokron C, Raile V. Occupational asthma caused by Ipe (Tabebuia spp) dust. J Investig Allergol Clin Immunol. 2005;15:81-3 pubmed
    ..Ipe is a resistant hardwood that contains naphtoquinones. It is easily found and frequently used in South and Central America. Naphtoquinones are skin sensitizers...
  6. Byeon S, Chung J, Lee Y, Kim B, Kim K, Cho J. In vitro and in vivo anti-inflammatory effects of taheebo, a water extract from the inner bark of Tabebuia avellanedae. J Ethnopharmacol. 2008;119:145-52 pubmed publisher
    b>Tabebuia spp. (Bignoniaceae) are native to tropical rain forests throughout Central and South America and have long been used as a folk medicine to treat bacterial infection, blood coagulation, cancer and inflammatory diseases...
  7. Pereira E, Machado T, Leal I, Jesus D, Damaso C, Pinto A, et al. Tabebuia avellanedae naphthoquinones: activity against methicillin-resistant staphylococcal strains, cytotoxic activity and in vivo dermal irritability analysis. Ann Clin Microbiol Antimicrob. 2006;5:5 pubmed
    ..study evaluated the antibacterial activity, toxicity and in vivo dermal irritability of lapachol extracted from Tabebuia avellanedae and derivatives against methicillin-resistant staphylococcal isolates...
  8. Son D, Lim Y, Park Y, Chang S, Yun Y, Hong J, et al. Inhibitory effects of Tabebuia impetiginosa inner bark extract on platelet aggregation and vascular smooth muscle cell proliferation through suppressions of arachidonic acid liberation and ERK1/2 MAPK activation. J Ethnopharmacol. 2006;108:148-51 pubmed
    The antiplatelet and antiproliferative activities of extract of Tabebuia impetiginosa inner bark (taheebo) were investigated using washed rabbit platelets and cultured rat aortic vascular smooth muscle cells (VSMCs) in vitro...
  9. Sanchez Azofeifa A, Rivard B, Wright J, Feng J, Li P, Chong M, et al. Estimation of the distribution of Tabebuia guayacan (Bignoniaceae) using high-resolution remote sensing imagery. Sensors (Basel). 2011;11:3831-51 pubmed publisher
    ..describe our use of high resolution imagery from the Quickbird Satellite to estimate the flowering population of Tabebuia guayacan trees at Barro Colorado Island (BCI), in Panama...

More Information

Publications75

  1. Yamashita M, Kaneko M, Tokuda H, Nishimura K, Kumeda Y, Iida A. Synthesis and evaluation of bioactive naphthoquinones from the Brazilian medicinal plant, Tabebuia avellanedae. Bioorg Med Chem. 2009;17:6286-91 pubmed publisher
    ..2), which are secondary metabolites found in the inner bark of Tabebuia avellanedae, were stereoselectively synthesized and their biological activities were evaluated in conjunction ..
  2. Warashina T, Nagatani Y, Noro T. Further constituents from the bark of Tabebuia impetiginosa. Phytochemistry. 2005;66:589-97 pubmed
    Further study on the constituents from the bark of Tabebuia impetiginosa (Mart...
  3. Gomez Castellanos J, Prieto J, Heinrich M. Red Lapacho (Tabebuia impetiginosa)--a global ethnopharmacological commodity?. J Ethnopharmacol. 2009;121:1-13 pubmed publisher
    Red Lapacho (Tabebuia impetiginosa, syn. Tabebuia avellanedae), a canopy tree indigenous to the Amazonian rainforest and other parts of South America, has been acclaimed to be one of the "miraculous" cures for cancer and tumours...
  4. Yamashita M, Kaneko M, Iida A, Tokuda H, Nishimura K. Stereoselective synthesis and cytotoxicity of a cancer chemopreventive naphthoquinone from Tabebuia avellanedae. Bioorg Med Chem Lett. 2007;17:6417-20 pubmed
    Stereoselective synthesis of 1, one of biologically active naphthoquinones from a Brazilian traditional medicine Tabebuia avellanedae, was achieved by utilizing Noyori reduction as a key step...
  5. Park B, Lee H, Lee S, Piao X, Takeoka G, Wong R, et al. Antibacterial activity of Tabebuia impetiginosa Martius ex DC (Taheebo) against Helicobacter pylori. J Ethnopharmacol. 2006;105:255-62 pubmed
    The growth-inhibiting activity of Tabebuia impetiginosa Martius ex DC dried inner bark-derived constituents against Helicobacter pylori ATCC 43504 was examined using paper disc diffusion and minimum inhibitory concentration (MIC) ..
  6. Woo H, Park K, Rhu C, Lee W, Choi B, Kim G, et al. Beta-lapachone, a quinone isolated from Tabebuia avellanedae, induces apoptosis in HepG2 hepatoma cell line through induction of Bax and activation of caspase. J Med Food. 2006;9:161-8 pubmed
    The DNA topoisomerase inhibitor beta-lapachone is a quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) in South America...
  7. de Miranda F, Vilar J, Alves I, Cavalcanti S, Antoniolli A. Antinociceptive and antiedematogenic properties and acute toxicity of Tabebuia avellanedae Lor. ex Griseb. inner bark aqueous extract. BMC Pharmacol. 2001;1:6 pubmed
    b>Tabebuia avellanedae is a tree from the Bignoniaceae family. Commonly know as "pau d'arco" in Brazil, its inner bark is used as analgesic, anti-inflammatory, antineoplasic and diuretic at the Brazilian northeast...
  8. de Melo W, Lima Ribeiro M, Terribile L, Collevatti R. Coalescent Simulation and Paleodistribution Modeling for Tabebuia rosealba Do Not Support South American Dry Forest Refugia Hypothesis. PLoS ONE. 2016;11:e0159314 pubmed publisher
    ..We studied the demographic history of Tabebuia rosealba (Bignoniaceae) to understand the disjunct geographic distribution of South American SDTFs based on ..
  9. Rahman M, Islam M, Biswas M, Khurshid Alam A. In vitro antioxidant and free radical scavenging activity of different parts of Tabebuia pallida growing in Bangladesh. BMC Res Notes. 2015;8:621 pubmed publisher
    ..Here, we aimed to investigate the antioxidant and free radical scavenging properties of methanolic extracts from Tabebuia pallida (T. pallida) stem bark (TPSB), root bark (TPRB), leaves (TPL), and flowers (TPF)...
  10. Moura B, Almeida P, Balliana A, Cobos J, Erbano M, do Prado K, et al. Effects of changes in micro-weather conditions on structural features, total protein and carbohydrate content in leaves of the Atlantic rain forest tree golden trumpet (Tabebuia chrysotricha). Braz J Biol. 2017;77:535-541 pubmed publisher
    Golden trumpet, Tabebuia chrysotricha, is a native tree from the Brazilian Atlantic rain forest, with a broad latitudinal distribution...
  11. Brito Rocha E, Schilling A, dos Anjos L, Piotto D, Dalmolin A, Mielke M. Regression models for estimating leaf area of seedlings and adult individuals of Neotropical rainforest tree species. Braz J Biol. 2016;76:983-989 pubmed publisher
    ..rubescens, Manilkara maxima, Pouteria caimito, Pouteria torta, Psidium cattleyanum, Symphonia globulifera and Tabebuia stenocalyx) with the objective to test the feasibility of single regression models to estimate LA of both adults ..
  12. Lee E, Ko H, Jeong Y, Park E, Kim H. β-Lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microglia. J Neuroinflammation. 2015;12:133 pubmed publisher
    Lapachone (β-LAP) is a natural naphthoquinone compound isolated from the lapacho tree (Tabebuia sp.), and it has been used for treatment of rheumatoid arthritis, infection, and cancer...
  13. Noguera M, Escandón P, Castañeda E. Cryptococcosis in Atlántico, Colombia: an approximation of the prevalence of this mycosis and the distribution of the etiological agent in the environment. Rev Soc Bras Med Trop. 2015;48:580-6 pubmed publisher
    ..e., Quickstick ( Gliricidia sepium ), Almond ( Terminalia catappa ), and Pink trumpet ( Tabebuia rosea ). Environmental and clinical samples/isolates were analyzed for phenotypic and genotypic confirmation...
  14. Milato J, Silva R, Figueiredo F, Azevedo D, Ribeiro C, Leitão G. Use of counter-current chromatography as a selective extractor for the diterpenequinone 7α-hydroxyroyleanone from Tetradenia riparia. J Chromatogr A. 2018;1537:135-140 pubmed publisher
    ..prompted by the extraction procedure used for the extraction of lapachol (a natural naphtoquinone) from a Tabebuia species wood...
  15. Pérez Hernández I, Ochoa Gaona S, Adams R, Rivera Cruz M, Pérez Hernández V, Jarquín Sánchez A, et al. Growth of four tropical tree species in petroleum-contaminated soil and effects of crude oil contamination. Environ Sci Pollut Res Int. 2017;24:1769-1783 pubmed publisher
    ..Cedrela odorata (tropical cedar), Haematoxylum campechianum (tinto bush), Swietenia macrophylla (mahogany), and Tabebuia rosea (macuilis)...
  16. Dalling J, Cernusak L, Winter K, Aranda J, Garcia M, Virgo A, et al. Two tropical conifers show strong growth and water-use efficiency responses to altered CO2 concentration. Ann Bot. 2016;118:1113-1125 pubmed
    ..Two conifers (Araucaria heterophylla and Podocarpus guatemalensis) and two angiosperm trees (Tabebuia rosea and Chrysophyllum cainito) were grown in climate-controlled glasshouses in Panama...
  17. Vitorino L, Lima Ribeiro M, Terribile L, Collevatti R. Demographical history and palaeodistribution modelling show range shift towards Amazon Basin for a Neotropical tree species in the LGM. BMC Evol Biol. 2016;16:213 pubmed
    We studied the phylogeography and demographical history of Tabebuia serratifolia (Bignoniaceae) to understand the disjunct geographical distribution of South American seasonally dry tropical forests (SDTFs)...
  18. Lambais M, Barrera S, Santos E, Crowley D, Jumpponen A. Phyllosphere Metaproteomes of Trees from the Brazilian Atlantic Forest Show High Levels of Functional Redundancy. Microb Ecol. 2017;73:123-134 pubmed publisher
    ..of four tree species of the Atlantic Forest (Mollinedia schottiana, Ocotea dispersa, Ocotea teleiandra, and Tabebuia serratifolia) and their metaproteomes to examine the basic protein functional groups expressed in the ..
  19. Iwamoto K, Fukuda Y, Tokikura C, Noda M, Yamamoto A, Yamamoto M, et al. The anti-obesity effect of Taheebo (Tabebuia avellanedae Lorentz ex Griseb) extract in ovariectomized mice and the identification of a potential anti-obesity compound. Biochem Biophys Res Commun. 2016;478:1136-40 pubmed publisher
    ..It is also associated with many adverse health conditions. Taheebo extract from Tabebuia avellanedae has been recognized as playing several biological and pharmacological roles...
  20. Park H, Lee S, Kwon D, Heo S, Park S, Kim S, et al. Oral administration of taheebo (Tabebuia avellanedae Lorentz ex Griseb.) water extract prevents DSS-induced colitis in mice by up-regulating type II T helper immune responses. BMC Complement Altern Med. 2017;17:448 pubmed publisher
    ..Previous studies have demonstrated that taheebo water extract (TWE) derived from Tabebuia avellanedae Lorentz ex Griseb., as folk remedy, has been used to treat various inflammatory diseases...
  21. Tsang N, Chik W, Sze L, Tsang S, Zhang H. The Use of Naphthoquinones and Furano-naphthoquinones as Anti-invasive Agents. Curr Med Chem. 2017;: pubmed publisher
    ..BBI608, a natural FNQ, which can be found in the woods or barks of several Tabebuia species, has entered phases I and II clinical trials...
  22. Cavalcante F, Monteiro F, Martins I, Barbosa T, Camara C, Pinto A, et al. Synthetic lapachol derivatives relax guinea-pig ileum by blockade of the voltage-gated calcium channels. Z Naturforsch C. 2010;65:627-36 pubmed
    ..2). In addition, in the functional level, the spasmolytic effect of beta-norlapachone does not involve participation of free radicals, since its curve of relaxation was unchanged in the presence of glutathione, an antioxidant agent...
  23. Duarte da Silva M, Bezerra B, Gomes Battistelle R, Valarelli I. Prospects for the use of municipal tree pruning wastes in particleboard production. Waste Manag Res. 2013;31:960-5 pubmed publisher
    ..study was to evaluate the physical and mechanical properties of particleboard made with pruning wastes from Ipê (Tabebuia serratifolia) and Chapéu-de-Sol (Terminalia catappa) trees...
  24. Bohler T, Nolting J, Gurragchaa P, Lupescu A, Neumayer H, Budde K, et al. Tabebuia avellanedae extracts inhibit IL-2-independent T-lymphocyte activation and proliferation. Transpl Immunol. 2008;18:319-23 pubmed
    ..We found for the extract of the inner bark of Tabebuia avellanedae (Tabebuia) dose dependent and reproducible inhibitory effects on lymphocyte proliferation...
  25. Maistro E, Fernandes D, Pereira F, Andrade S. Lapachol induces clastogenic effects in rats. Planta Med. 2010;76:858-62 pubmed publisher
    ..occurring naphthoquinone derivative found in the heartwood of several plants, particularly those of the genus Tabebuia (Bignoneaceae)...
  26. Moon D, Kang C, Kim M, Jeon Y, Lee J, Choi Y, et al. Beta-lapachone (LAPA) decreases cell viability and telomerase activity in leukemia cells: suppression of telomerase activity by LAPA. J Med Food. 2010;13:481-8 pubmed publisher
    ..Recent reports have suggested that beta-lapachone (LAPA), the product of the South American Tabebuia avellanedae tree, inhibits growth of tumor cells...
  27. Theoduloz C, Carrión I, Pertino M, Valenzuela D, Schmeda Hirschmann G. Potential gastroprotective effect of novel cyperenoic acid/quinone derivatives in human cell cultures. Planta Med. 2012;78:1807-12 pubmed publisher
    The stem bark of Tabebuia species and the rhizomes of Jatropha isabelii are used in Paraguayan traditional medicine to treat gastric lesions and as anti-inflammatory agents. The sesquiterpene cyperenoic acid obtained from J...
  28. Nossa P, Guenka L, Couto L, da Cruz Perez D. Effects of the serjania erecta and zeyheria montana ethanol extracts in experimental pulpitis in rats: a histological study. Med Oral Patol Oral Cir Bucal. 2013;18:e337-42 pubmed
    ..The aim of this study was to evaluate, by the semi-quantitative histological analysis, the anti-inflammatory activity of the ethanolic extracts of Serjania erecta e Zeyheria Montana, in experimental pulpits in rats...
  29. Plath M, Dorn S, Riedel J, Barrios H, Mody K. Associational resistance and associational susceptibility: specialist herbivores show contrasting responses to tree stand diversification. Oecologia. 2012;169:477-87 pubmed publisher
    ..We tested the associational effects of tree diversity on herbivory patterns of the tropical focal tree Tabebuia rosea in an experimental plantation setup, which contained tree monocultures and mixed stands...
  30. Kim M, Jeon J, Lee H. Larvicidal activity of the active constituent isolated from Tabebuia avellanedae bark and structurally related derivatives against three mosquito species. J Agric Food Chem. 2013;61:10741-5 pubmed publisher
    Mosquito larvicidal activities of active constituent isolated from Tabebuia avellanedae bark and its structurally related derivatives were examined against the fourth instar larvae of Aedes aegypti, Culex pipiens pallens, and Ochlerotatus ..
  31. Freitas A, Moretti M, Budni J, Balen G, Fernandes S, Veronezi P, et al. NMDA receptors and the L-arginine-nitric oxide-cyclic guanosine monophosphate pathway are implicated in the antidepressant-like action of the ethanolic extract from Tabebuia avellanedae in mice. J Med Food. 2013;16:1030-8 pubmed publisher
    Bark infusion of Tabebuia avellanedae Lorentz ex Griseb is consumed in tropical America folk medicine for the treatment of several diseases, including depressive disorders...
  32. Sichaem J, Kaennakam S, Siripong P, Tip Pyang S. Tabebuialdehydes A-C, cyclopentene dialdehyde derivatives from the roots of Tabebuia rosea. Fitoterapia. 2012;83:1456-9 pubmed publisher
    ..monoaldehyde, tabebuialdehyde C (3), along with ten known compounds were isolated from the roots of Tabebuia rosea...
  33. Freitas A, Machado D, Budni J, Neis V, Balen G, Lopes M, et al. Antidepressant-like action of the bark ethanolic extract from Tabebuia avellanedae in the olfactory bulbectomized mice. J Ethnopharmacol. 2013;145:737-45 pubmed publisher
    b>Tabebuia avellanedae Lorentz ex Griseb is a plant employed in tropical America folk medicine for the treatment of several diseases, including depressive disorders.
  34. Zabka A, Trzaskoma P, Maszewski J. Dissimilar effects of ?-lapachone- and hydroxyurea-induced DNA replication stress in root meristem cells of Allium cepa. Plant Physiol Biochem. 2013;73:282-93 pubmed publisher
  35. Queiroz M, Valadares M, Torello C, Ramos A, Oliveira A, Rocha F, et al. Comparative studies of the effects of Tabebuia avellanedae bark extract and beta-lapachone on the hematopoietic response of tumour-bearing mice. J Ethnopharmacol. 2008;117:228-35 pubmed publisher
    The effects of Tabebuia avellanedae (TACE), traditionally prescribed in the treatment of cancer, and the naphtoquinone beta-lapachone (beta-lap) on the growth and differentiation of granulocyte and macrophage progenitor cells (CFU-GM) ..
  36. Lemos T, Monte F, Santos A, Fonseca A, Santos H, Oliveira M, et al. Quinones from plants of northeastern Brazil: structural diversity, chemical transformations, NMR data and biological activities. Nat Prod Res. 2007;21:529-50 pubmed
    ..in quinones found in species of Brazilian northeastern Capraria biflora, Lippia sidoides, Lippia microphylla and Tabebuia serratifolia...
  37. Sullivan J. Density-dependent shoot-borer herbivory increases the age of first reproduction and mortality of neotropical tree saplings. Oecologia. 2003;136:96-106 pubmed
    ..large direct and indirect effects on the rates of height increment and mortality of saplings of its host tree, Tabebuia ochracea (Bignoniaceae), in the secondary successional tropical dry forests of the Area de Conservación ..
  38. Lopez O, Kursar T. Does flood tolerance explain tree species distribution in tropical seasonally flooded habitats?. Oecologia. 2003;136:193-204 pubmed
    ..For example, after 90 days, flooding reduced leaf area growth by 10-50% in all species, except in Tabebuia, a common species from non-flooded habitats...
  39. Inagaki R, Ninomiya M, Tanaka K, Watanabe K, Koketsu M. Synthesis and cytotoxicity on human leukemia cells of furonaphthoquinones isolated from tabebuia plants. Chem Pharm Bull (Tokyo). 2013;61:670-3 pubmed
    ..In particular, methoxylated furonaphthoquinones are characteristic constituents of Tabebuia plants...
  40. Santacruz A, Valdez Herández J, Angeles Pérez G, Musálem Santiago M, Vaquera Huerta H. [Establishment and development of Tabebuia rosea (Bignoniaceae) seedlings in a semideciduous tropical forest under management, Pacific coast of Mexico]. Rev Biol Trop. 2006;54:1215-25 pubmed
    ..and vegetation clearing treatments on the natural regeneration and initial development of Tabebuia rosea (Bertold) DC...
  41. Lipinski L, Wouk A, da Silva N, Perotto D, Ollhoff R. Effects of 3 topical plant extracts on wound healing in beef cattle. Afr J Tradit Complement Altern Med. 2012;9:542-7 pubmed
    ..treated for 17 days with a saline control or decoctions of Schinus terebinthifolius Raddi (Aroeira mansa), Tabebuia avellanedae Lorentz ex Griseb (Ipê Roxo), and Casearia sylvestris Sw...
  42. Ragusa Netro J. Extensive consumption of Tabebuia aurea (Manso) Benth. & Hook. (Bignoniaceae) nectar by parrots in a Tecoma savanna in the southern Pantanal (Brazil). Braz J Biol. 2005;65:339-44 pubmed
    ..activity during a brief synchronous and massive flowering in August 1998 in a tecoma savanna (dominated by Tabebuia aurea) in the southern Pantanal...
  43. de Cássia da Silveira E Sá R, de Oliveira Guerra M. Reproductive toxicity of lapachol in adult male Wistar rats submitted to short-term treatment. Phytother Res. 2007;21:658-62 pubmed
    ..The results suggest a reproductive toxicity effect of lapachol, indicating the seminal vesicle as a possible target organ...
  44. Suo M, Yan S. Iridoid Glycosides from Tabebuia avellanedae. Chem Biodivers. 2016;13:1611-1616 pubmed publisher
    Five novel iridoid glycosides, avellanedaesides A-E (1 - 5) were isolated from the H2 O extract of Tabebuia avellanedae. Their structures were determined on the basis of NMR and MS analysis...
  45. Mistrangelo M, Cornaglia S, Pizzio M, Rimonda R, Gavello G, Dal Conte I, et al. Immunostimulation to reduce recurrence after surgery for anal condyloma acuminata: a prospective randomized controlled trial. Colorectal Dis. 2010;12:799-803 pubmed publisher
    ..Human papillomavirus is the most common cause of sexually transmitted disease. It is associated with immunosuppression and shows a marked tendency to recur. We investigated a natural immunostimulant aimed to reduce recurrence...
  46. Wright S, Trakhtenbrot A, Bohrer G, Detto M, Katul G, Horvitz N, et al. Understanding strategies for seed dispersal by wind under contrasting atmospheric conditions. Proc Natl Acad Sci U S A. 2008;105:19084-9 pubmed publisher
    ..Several of the same plant traits are crucial for both seed dispersal and other aspects of life history variation. Observed traits that limit dispersal are likely to be constrained by their life history consequences...
  47. Awale S, Kawakami T, Tezuka Y, Ueda J, Tanaka K, Kadota S. Nitric oxide (NO) production inhibitory constituents of Tabebuia avellanedae from Brazil. Chem Pharm Bull (Tokyo). 2005;53:710-3 pubmed
    From the water extract of Brazilian Tabebuia avellanedae, two new iridoids (1, 2) and a new phenylethanoid glycoside (3) have been isolated together with twelve known compounds (4-15)...
  48. Lamberti M, Vittar N, da Silva F, Ferreira V, Rivarola V. Synergistic enhancement of antitumor effect of ?-Lapachone by photodynamic induction of quinone oxidoreductase (NQO1). Phytomedicine. 2013;20:1007-12 pubmed publisher
    ..The combination of ?-Lapachone and PDT is a potentially promising modality for the treatment of cancer. ..
  49. Hussain H, Green I. Lapachol and lapachone analogs: a journey of two decades of patent research(1997-2016). Expert Opin Ther Pat. 2017;27:1111-1121 pubmed publisher
    Lapachol (1), ?-lapachone (2) and ?-lapachone (3) are three well-studied natural products isolated from Tabebuia impetiginosa having most interesting chemodiversity and demonstrating diverse biological effects...
  50. Lee H, Ko W, Lee H, Chen H. Clinical manifestations and complications of rickettsiosis in southern Taiwan. J Formos Med Assoc. 2002;101:385-92 pubmed
    ..This study describes the clinical manifestations and complications of cases of rickettsial infections treated at a medical center in southern Taiwan...
  51. Suo M, Ohta T, Takano F, Jin S. Bioactive phenylpropanoid glycosides from Tabebuia avellanedae. Molecules. 2013;18:7336-45 pubmed publisher
    Three novel phenylpropanoid glycosides 2, 5, 6 were isolated from water extract of Tabebuia avellanedae, together with three known phenylpropanoid glycosides 1, 3, 4...
  52. Suo M, Isao H, Kato H, Takano F, Ohta T. Anti-inflammatory constituents from Tabebuia avellanedae. Fitoterapia. 2012;83:1484-8 pubmed publisher
    Five novel compounds were isolated from the water extract of Tabebuia avellanedae, and their structures were established by analysis of NMR spectroscopy and mass spectrometry...
  53. Lee M, Choi H, Hahm D, Her E, Yang H, Yoo M, et al. Analgesic and anti-inflammatory effects in animal models of an ethanolic extract of Taheebo, the inner bark of Tabebuia avellanedae. Mol Med Rep. 2012;6:791-6 pubmed publisher
    Taheebo, the purple inner bark of the Bignoniaceae tree Tabebuia avellanedae Lorentz ex Griseb, which is found in tropical rain forests in northeastern Brazil, has been used as a traditional medicine for various diseases for more than 1,..
  54. Higa R, Aydos R, Silva I, Ramalho R, Souza A. Study of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in mice. Acta Cir Bras. 2011;26:125-8 pubmed
    To study the antitumor action of Tabebuia avellanedae in experimentally induced colon carcinogenesis by azoxymethane in mice.
  55. Melo e Silva F, de Paula J, Espindola L. Evaluation of the antifungal potential of Brazilian Cerrado medicinal plants. Mycoses. 2009;52:511-7 pubmed publisher
    ..Extracts of Kielmeyera coriacea, Renealmia alpinia, Stryphnodendron adstringens and Tabebuia caraiba were very active against T. rubrum, presented geometric means of the MIC values between 170.39 and 23...
  56. Machado T, Pinto A, Pinto M, Leal I, Silva M, Amaral A, et al. In vitro activity of Brazilian medicinal plants, naturally occurring naphthoquinones and their analogues, against methicillin-resistant Staphylococcus aureus. Int J Antimicrob Agents. 2003;21:279-84 pubmed
    ..Staphylococcus aureus strains were susceptible to extracts of Punica granatum and Tabebuia avellanedae...
  57. Kiage Mokua B, Roos N, Schrezenmeir J. Lapacho tea (Tabebuia impetiginosa) extract inhibits pancreatic lipase and delays postprandial triglyceride increase in rats. Phytother Res. 2012;26:1878-83 pubmed publisher
    Earlier work in our laboratory indicated that ethanolic extracts of Tabebuia impetiginosa, Arctium lappa L., Calendula officinalis, Helianthus annuus, Linum usitatissimum and L. propolis, inhibit pancreatic lipase in vitro...
  58. Garkavtsev I, Chauhan V, Wong H, Mukhopadhyay A, Glicksman M, Peterson R, et al. Dehydro-alpha-lapachone, a plant product with antivascular activity. Proc Natl Acad Sci U S A. 2011;108:11596-601 pubmed publisher
    ..We show that DAL targets cell adhesion by promoting ubiquitination of the Rho-GTPase Rac1, which is frequently up-regulated in many different cancers...
  59. Budán F, Szabo I, Varjas T, Nowrasteh G, Dávid T, Gergely P, et al. Mixtures of Uncaria and Tabebuia extracts are potentially chemopreventive in CBA/Ca mice: a long-term experiment. Phytother Res. 2011;25:493-500 pubmed publisher
    ..U. tomentosa) and Palmer trumpet-tree (Tabebuia sp. T...
  60. Mukherjee B, Telang N, Wong G. Growth inhibition of estrogen receptor positive human breast cancer cells by Taheebo from the inner bark of Tabebuia avellandae tree. Int J Mol Med. 2009;24:253-60 pubmed
    ..Taheebo, extracted from the inner bark of the Tabebuia avellandae tree found in the Brazilian Amazon, exhibits selective anti-proliferative effects in carcinoma cell ..
  61. Twardowschy A, Freitas C, Baggio C, Mayer B, dos Santos A, Pizzolatti M, et al. Antiulcerogenic activity of bark extract of Tabebuia avellanedae, Lorentz ex Griseb. J Ethnopharmacol. 2008;118:455-9 pubmed publisher
    b>Tabebuia avellanedae is commonly used for the treatment of peptic ulcers...
  62. Woo H, Choi Y. Growth inhibition of A549 human lung carcinoma cells by beta-lapachone through induction of apoptosis and inhibition of telomerase activity. Int J Oncol. 2005;26:1017-23 pubmed
    ..study was to investigate the effect of beta-lapachone, a quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae), on the cell growth and apoptosis in human lung carcinoma cell line A549...
  63. Park B, Kim J, Lee S, Kim K, Takeoka G, Ahn Y, et al. Selective growth-inhibiting effects of compounds identified in Tabebuia impetiginosa inner bark on human intestinal bacteria. J Agric Food Chem. 2005;53:1152-7 pubmed
    ..activity of anthraquinone-2-carboxylic acid and lapachol identified in the inner bark of taheebo, Tabebuia impetiginosa, toward 10 human intestinal bacteria was evaluated by using a paper disk diffusion bioassay and ..
  64. Macedo L, Fernandes T, Silveira L, Mesquita A, Franchitti A, Ximenes E. ?-Lapachone activity in synergy with conventional antimicrobials against methicillin resistant Staphylococcus aureus strains. Phytomedicine. 2013;21:25-9 pubmed publisher
    ..This study demonstrated that, in general, ?-lapachone combined with beta lactams antimicrobials, fluoroquinolones and carbapenems acts synergistically inhibiting MRSA strains. ..
  65. Costa W, Oliveira A, Nepomuceno J. Lapachol as an epithelial tumor inhibitor agent in Drosophila melanogaster heterozygote for tumor suppressor gene wts. Genet Mol Res. 2011;10:3236-45 pubmed publisher
    ..Lapachol, a natural organic compound isolated from the lapacho tree (Tabebuia avellandedae), is chemically identified as belonging to the naphthoquinone group and is known for its anti-..
  66. Pertino M, Theoduloz C, Palenzuela J, Afonso M, Yesilada E, Monsalve F, et al. Synthesis and pharmacological activity of diterpenylnaphthoquinone derivatives. Molecules. 2011;16:8614-28 pubmed publisher
    ..Several of the new compounds were significantly active as antiulcer agents and showed selective cytotoxicity against AGS cells...