sophora

Summary

Summary: A plant genus of the family FABACEAE.

Top Publications

  1. Zhang L, Liu W, Zhang R, Wang Z, Shen Z, Chen X, et al. Pharmacokinetic study of matrine, oxymatrine and oxysophocarpine in rat plasma after oral administration of Sophora flavescens Ait. extract by liquid chromatography tandem mass spectrometry. J Pharm Biomed Anal. 2008;47:892-8 pubmed publisher
    ..of matrine (MT), oxymatrine (OMT) and oxysophocarpine (OSP) in rat plasma after oral administration of Sophora flavescens Ait. extract using pseudoephedrine hydrochloride as an internal standard (I.S.)...
  2. Shen C, Lin T, Huang Y, Wan S, Shien B, Chen C. Phenolic constituents of the roots of Sophora flavescens. J Nat Prod. 2006;69:1237-40 pubmed
    From the roots of Sophora flavescens collected in Taiwan, four new prenylflavonoids, sophoraflavanone K (1), sophoraflavanone L (2), 8-lavandulylkaempferol (3), and cyclokuraridin (4), a new arylbenzofuran, 2-(2,4-dihydroxy-5-..
  3. Yang J, Ip S, Xian Y, Zhao M, Lin Z, Yeung J, et al. Impact of the herbal medicine Sophora flavescens on the oral pharmacokinetics of indinavir in rats: the involvement of CYP3A and P-glycoprotein. PLoS ONE. 2012;7:e31312 pubmed publisher
    b>Sophora flavescens is a Chinese medicinal herb used for the treatment of gastrointestinal hemorrhage, skin diseases, pyretic stranguria and viral hepatitis. In this study the herb-drug interactions between S...
  4. Ryu Y, Curtis Long M, Kim J, Jeong S, Yang M, Lee K, et al. Pterocarpans and flavanones from Sophora flavescens displaying potent neuraminidase inhibition. Bioorg Med Chem Lett. 2008;18:6046-9 pubmed publisher
    Pterocarpans (1-3) and flavanones (4-10) were isolated from Sophora flavescens and screened for their ability to inhibit neuraminidase (an enzyme crucial in the proliferation of the influenza virus)...
  5. Kim J, Yun Choi H. Anti-platelet effects of flavonoids and flavonoid-glycosides from Sophora japonica. Arch Pharm Res. 2008;31:886-90 pubmed publisher
    A methanol extract of Sophora japonica was subjected to anti-platelet activity guided fractionation affording the isolation of four flavonoids and six flavonoid-glycosides: biochanin A (1), irisolidone (2), genistein (3), sissotrin (4), ..
  6. Hwang J, Lee S, Hong S, Lee K, Lee M, Hwang B, et al. Monoamine oxidase inhibitory components from the roots of Sophora flavescens. Arch Pharm Res. 2005;28:190-4 pubmed
    ..for monoamine oxidase (MAO) inhibitors from natural resources, we found that the methanol extract of the roots of Sophora flavescens showed an inhibitory effect on mouse brain monoamine oxidase (MAO)...
  7. Li T, Yin X, Liu D, Ma X, Lv H, Sun S. Isolation and characterization of a novel lectin with antifungal and antiproliferative activities from Sophora alopecuroides seeds. Acta Biochim Biophys Sin (Shanghai). 2012;44:606-13 pubmed publisher
    b>Sophora alopecuroides lectin (SAL), a novel lectin from the seeds of Sophora alopecuroides, was purified by ion-exchange chromatography on diethylaminoethyl (DEAE)- and carboxymethyl (CM)-Sepharose columns, followed by gel filtration on ..
  8. Zhou Y, Wei Y, Liu H, Zhang G, Wu X. Preparation and in vitro evaluation of ethosomal total alkaloids of Sophora alopecuroides loaded by a transmembrane pH-gradient method. AAPS PharmSciTech. 2010;11:1350-8 pubmed publisher
    ..Using this novel method, binary ethosomes containing total alkaloids extracted from Sophora alopecuroides (TASA) were prepared successfully at the temperature below the phase transition temperature (Tc) of ..
  9. Jung H, Kang S, Hyun S, Choi J. In vitro free radical and ONOO- scavengers from Sophora flavescens. Arch Pharm Res. 2005;28:534-40 pubmed
    Activity-guided fractionation of the CH2Cl2-soluble fraction of the roots of Sophora flavescens furnished five 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavengers: trans-hexadecyl ferulic acid (1), cis-octadecyl ferulic acid (2),..

More Information

Publications67

  1. Youn H, Lakritz J, Rottinghaus G, Seo H, Kim D, Cho M, et al. Anti-protozoal efficacy of high performance liquid chromatography fractions of Torilis japonica and Sophora flavescens extracts on Neospora caninum and Toxoplasma gondii. Vet Parasitol. 2004;125:409-14 pubmed
    We previously reported that alcoholic extracts of Sophora flavescens and Torilis japonica from South Korea demonstrated good efficacy in reducing replication of Toxoplasma gondii and Neospora caninum...
  2. Wang Z, Sun J, Wang D, Xie Y, Wang S, Zhao W. Pharmacological studies of the large-scaled purified genistein from Huaijiao (Sophora japonica-Leguminosae) on anti-osteoporosis. Phytomedicine. 2006;13:718-23 pubmed
    In this report, we used genistein that was extracted from a Chinese herbal medicine Huaijiao (Sophora japonica-Leguminosae) to evaluate its pharmacological function on anti-osteoporosis...
  3. Han C, Guo J. Antibacterial and anti-inflammatory activity of traditional Chinese herb pairs, Angelica sinensis and Sophora flavescens. Inflammation. 2012;35:913-9 pubmed publisher
    ..study was to investigate the antibacterial and anti-inflammatory activity of Angelica sinensis extract (AE), Sophora flavescens extract (SE), and herb pair A. sinensis and S. flavescens extract (HPE)...
  4. De Naeyer A, Vanden Berghe W, Pocock V, Milligan S, Haegeman G, De Keukeleire D. Estrogenic and anticarcinogenic properties of kurarinone, a lavandulyl flavanone from the roots of Sophora flavescens. J Nat Prod. 2004;67:1829-32 pubmed
    Kurarinone, a lavandulyl flavanone, was isolated from a polyphenolic extract of the roots of Sophora flavescens using fractionation guided by estrogenic activity, which was determined by recombinant yeast and Ishikawa Var-I bioassays...
  5. Runtao G, Guo D, Jiangbo Y, Xu W, Shusen Y. Oxymatrine, the main alkaloid component of Sophora roots, protects heart against arrhythmias in rats. Planta Med. 2011;77:226-30 pubmed publisher
    Oxymatrine is one of the main alkaloid components extracted from SOPHORA roots and has been shown to play various protective roles in the cardiovascular system...
  6. Hyun S, Lee W, Jeong D, Kim Y, Choi J. Inhibitory effects of kurarinol, kuraridinol, and trifolirhizin from Sophora flavescens on tyrosinase and melanin synthesis. Biol Pharm Bull. 2008;31:154-8 pubmed
    ..reported that some prenylated flavonoids contained in the dichloromethane fraction of the ethanolic extract of Sophora flavescens, such as kuraridin, sophoraflavanone G, kurarinone, and kushenol F, are tyrosinase inhibitors; however,..
  7. Cao Y, Jing S, Li L, Gao J, Shen Z, Liu Y, et al. Antiarrhythmic effects and ionic mechanisms of oxymatrine from Sophora flavescens. Phytother Res. 2010;24:1844-9 pubmed publisher
    ..The beneficial effects of oxymatrine may be related to the shortening of APD through reduction of I(Ca-L) , enhancement of I(to) and inhibition of I(K1)...
  8. Funaya N, Haginaka J. Matrine- and oxymatrine-imprinted monodisperse polymers prepared by precipitation polymerization and their applications for the selective extraction of matrine-type alkaloids from Sophora flavescens Aiton. J Chromatogr A. 2012;1248:18-23 pubmed publisher
    ..MIP(MT) was used to selectively extract MT and sophocarpine (13,14-dehydromatrine) from Sophora flavescens root, while MIP(OMT) was used to extract OMT and oxysophocarpine (13,14-dehydrooxymatrine).
  9. Sasaki K, Mito K, Ohara K, Yamamoto H, Yazaki K. Cloning and characterization of naringenin 8-prenyltransferase, a flavonoid-specific prenyltransferase of Sophora flavescens. Plant Physiol. 2008;146:1075-84 pubmed publisher
    ..We have isolated a prenyltransferase gene from Sophora flavescens, SfN8DT-1, responsible for the prenylation of the flavonoid naringenin at the 8-position, which is ..
  10. Ueng Y, Chen C, Tsai C, Soucek P. Differential inductive profiles of hepatic cytochrome P450s by the extracts of Sophora flavescens in male and female C57BL/6JNarl mice. J Ethnopharmacol. 2009;126:437-46 pubmed publisher
    b>Sophora flavescens has been used as an antipyretic and analgesic agent. To assess the possible herb-drug interaction, effects of S. flavescens extracts on hepatic cytochrome P450 (P450, CYP) enzymes were studied.
  11. Jung S, Kim Y, Gwon A, Lee J, Jo D, Jeon T, et al. Genistein mediates the anti-adipogenic actions of Sophora japonica L. extracts. J Med Food. 2011;14:360-8 pubmed publisher
    Previous studies showed that feeding diets containing the mature fruits of Sophora japonica L. prevented body weight gain and reduced fat mass in high-fat diet-induced obese mice...
  12. Liang L, Wang X, Zhang X, Zhao W, Deng H. [Screening on alkaloid of Sophora alopecuraides against adenocarcinoma of colon cell line SW620 in vitro]. Zhong Yao Cai. 2008;31:866-9 pubmed
    To test 5 kinds of alkaloid of Sophora alopecuraides L., the effects of TBSA, MT, OMT, SC, SRI against adenocarcinoma of colon cell line SW620.
  13. Jin J, Kim J, Kang S, Son K, Chang H, Kim H. Anti-inflammatory and anti-arthritic activity of total flavonoids of the roots of Sophora flavescens. J Ethnopharmacol. 2010;127:589-95 pubmed publisher
    The roots of Sophora flavescens have long been used in Chinese medicine for the treatment of fever, inflammatory disorders, ulcers and skin burns. Sophora flavescens contains flavonoids and alkaloids.
  14. Shen Y, Feng Z, Jiang J, Yang Y, Zhang P. Dibenzoyl and isoflavonoid glycosides from Sophora flavescens: inhibition of the cytotoxic effect of D-galactosamine on human hepatocyte HL-7702. J Nat Prod. 2013;76:2337-45 pubmed publisher
    ..sophodibenzoside A-L (1-12) and five new isoflavone glycosides (13-17) have been isolated from the roots of Sophora flavescens together with eight known compounds (18-25)...
  15. Kim S, Son K, Chang H, Kang S, Kim H. Tyrosinase inhibitory prenylated flavonoids from Sophora flavescens. Biol Pharm Bull. 2003;26:1348-50 pubmed
    For the purpose of the development of a skin-whitening agent, Sophora flavescens was evaluated for tyrosinase inhibitory activity and its active principles were identified following activity-guided isolation...
  16. Choi B, Oh G, Lee J, Mok J, Kim D, Jeong S, et al. Prenylated chalcone from Sophora flavescens suppresses Th2 chemokine expression induced by cytokines via heme oxygenase-1 in human keratinocytes. Arch Pharm Res. 2010;33:753-60 pubmed publisher
    We recently reported the inhibitory effect of an oral administration of a Sophora flavescens Aiton methanol extract on the development of atopic dermatitis in the NC/Nga model mice...
  17. Lo Y, Lin R, Lin Y, Liu Y, Lee M. Active constituents from Sophora japonica exhibiting cellular tyrosinase inhibition in human epidermal melanocytes. J Ethnopharmacol. 2009;124:625-9 pubmed publisher
    There is greater consumer awareness of plant-based skin-care products. Sophora japonica L. (Fabaceae) has been used traditionally as a hemostatic agent and also has skin-care and whitening benefits...
  18. Ye G, Zhu H, Li Z, Ma C, Fan M, Sun Z, et al. LC-MS characterization of efficacy substances in serum of experimental animals treated with Sophora flavescens extracts. Biomed Chromatogr. 2007;21:655-60 pubmed
    Anti-DHBV (duck hepatitis B virus) activity was found in the aqueous extracts of Sophora flavescens Ait. in vivo...
  19. Sato S, Takeo J, Aoyama C, Kawahara H. Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens. Bioorg Med Chem. 2007;15:3445-9 pubmed
    The methanol extract of Sophora flavescens, which is used in traditional Chinese medicine (sophorae radix), showed potent Na(+)-glucose cotransporter (SGLT) inhibitory activity...
  20. Zhang L, Xu L, Xiao S, Liao Q, Li Q, Liang J, et al. Characterization of flavonoids in the extract of Sophora flavescens Ait. by high-performance liquid chromatography coupled with diode-array detector and electrospray ionization mass spectrometry. J Pharm Biomed Anal. 2007;44:1019-28 pubmed
    ..ionization mass spectrometry (ESI) was established for the separation and characterization of flavonoids in Sophora flavescens Ait. Based on the chromatographic separation of most flavonoids present in S. flavescens Ait...
  21. Roh S, Kim C, Lee M, Hwang S, Rang M, Yoon Y. The hair growth promoting effect of Sophora flavescens extract and its molecular regulation. J Dermatol Sci. 2002;30:43-9 pubmed
    In search of natural extracts for hair growth, we found that the extract of dried root of Sophora flavescens has outstanding hair growth promoting effect...
  22. Ueng Y, Tsai C, Lo W, Yun C. Induction of hepatic cytochrome P450s by the herbal medicine Sophora flavescens extract in rats: impact on the elimination of theophylline. Drug Metab Pharmacokinet. 2010;25:560-7 pubmed
    The roots of Sophora flavescens (Sf) have been widely used as a herbal medicine for the treatment of diarrhea, gastrointestinal hemorrhage, and eczema...
  23. Park S, Nam K, Lee H, Cho E, Koo U, Mar W. Neuroprotective effects of an alkaloid-free ethyl acetate extract from the root of Sophora flavescens Ait. against focal cerebral ischemia in rats. Phytomedicine. 2009;16:1042-51 pubmed publisher
    ..Oxymatrine and matrine are two major alkaloids of the Chinese herb Sophora flavescens Ait...
  24. Zhao P, Hamada C, Inoue K, Yamamoto H. Efficient production and capture of 8-prenylnaringenin and leachianone G-biosynthetic intermediates of sophoraflavanone G--by the addition of cork tissue to cell suspension cultures of Sophora flavescens. Phytochemistry. 2003;62:1093-9 pubmed
    It has previously been demonstrated that the addition of cork tissue to cell suspension cultures of Sophora flavescens stimulates the production of sophoraflavanone G, most of which has been recovered from the added cork tissue...
  25. Tang Y, Li Y, Hu J, Lou F. Isolation and identification of antioxidants from Sophora japonica. J Asian Nat Prod Res. 2002;4:123-8 pubmed
    ..3), were isolated from the n-BuOH extract of the pericarps of Sophora japonica by bioassay-guided fractionation...
  26. Han C, Wei H, Guo J. Anti-inflammatory effects of fermented and non-fermented Sophora flavescens: a comparative study. BMC Complement Altern Med. 2011;11:100 pubmed publisher
    The roots of Sophora flavescens (Leguminosae) have been used in East Asian countries as an herbal medicine and a food ingredient for thousands of years. The aim of the present study was to investigate the effects of S...
  27. Cha J, Jeong M, Jeong S, Lee K. Antibacterial activity of sophoraflavanone G isolated from the roots of Sophora flavescens. J Microbiol Biotechnol. 2007;17:858-64 pubmed
    This study investigated the antibacterial activities of sophoraflavanone G from Sophora flavescens in combination with two antimicrobial agents against oral bacteria...
  28. Ling J, Zhang G, Cui Z, Zhang C. Supercritical fluid extraction of quinolizidine alkaloids from Sophora flavescens Ait. and purification by high-speed counter-current chromatography. J Chromatogr A. 2007;1145:123-7 pubmed
    Supercritical fluid extraction (SFE) was used to extract quinolizidine alkaloids from Sophora flavescens Ait. (Kushen)...
  29. Rasul A, Yu B, Yang L, Ali M, Khan M, Ma T, et al. Induction of mitochondria-mediated apoptosis in human gastric adenocarcinoma SGC-7901 cells by kuraridin and Nor-kurarinone isolated from Sophora flavescens. Asian Pac J Cancer Prev. 2011;12:2499-504 pubmed
    ..For this purpose, we screened an ethanol extract of 300 herbs against SGC-7901 cells. Sophora flavescen was included in those showing potential cytotoxic activity...
  30. Sohn H, Son K, Kwon C, Kwon G, Kang S. Antimicrobial and cytotoxic activity of 18 prenylated flavonoids isolated from medicinal plants: Morus alba L., Morus mongolica Schneider, Broussnetia papyrifera (L.) Vent, Sophora flavescens Ait and Echinosophora koreensis Nakai. Phytomedicine. 2004;11:666-72 pubmed
    ..These results support the use of prenylated flavonoids in Asian traditional medicine to treat microbial infection and indicate a high potential for prenylated flavonoids as antimicrobial agents as well as anti-inflammatory agents...
  31. El Halawany A, Chung M, Abdallah H, Nishihara T, Hattori M. Estrogenic activity of a naringinase-treated extract of Sophora japonica cultivated in Egypt. Pharm Biol. 2010;48:177-81 pubmed publisher
    The naringinase-treated methanol extract of Sophora japonica L. (Fabaceae) seeds showed potent estrogen agonist activity...
  32. Daikonya A, Kitanaka S. Polyphenols from Sophora yunnanensis, and their inhibitory effects on nitric oxide production. Chem Pharm Bull (Tokyo). 2011;59:1567-9 pubmed
    ..named sophorayunnanol (1), together with eight known polyphenols (2-9), were isolated from the roots of Sophora yunnanensis C.Y.MA (Leguminosae)...
  33. Han J, Jin Y, Kim H, Park K, Lee W, Jeong T. Lavandulyl flavonoids from Sophora flavescens suppress lipopolysaccharide-induced activation of nuclear factor-kappaB and mitogen-activated protein kinases in RAW264.7 cells. Biol Pharm Bull. 2010;33:1019-23 pubmed
    ..Previously, we examined LDL-antioxidant activities of the nine flavonoids isolated from Sophora flavescens...
  34. Zhao L, Deng Z, Yang W, Cao Y, Wang E, Wei G. Diverse rhizobia associated with Sophora alopecuroides grown in different regions of Loess Plateau in China. Syst Appl Microbiol. 2010;33:468-77 pubmed publisher
    A total of seventy-five symbiotic bacterial strains isolated from root nodules of wild Sophora alopecuroides grown in different regions of China's Loess Plateau were characterized...
  35. Shuai X, Hu T, Liu H, Su Z, Zeng Y, Li Y. Immunomodulatory effect of a Sophora subprosrate polysaccharide in mice. Int J Biol Macromol. 2010;46:79-84 pubmed publisher
    The aims of the present study were to investigate the immunomodulatory effect of a Sophora subprosrate polysaccharide (SSP1) on splenic lymphocyte proliferation, production of cytokines and antioxidant capacities in dexamethasone-induced ..
  36. Song J, Clemens J, Jameson P. Quantitative expression analysis of the ABC genes in Sophora tetraptera, a woody legume with an unusual sequence of floral organ development. J Exp Bot. 2008;59:247-59 pubmed publisher
    b>Sophora is a woody genus of the Leguminosae in which an unusual order and process of floral organ development is often observed...
  37. Son J, Park J, Kim J, Kim Y, Chung S, Lee S. Prenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activity. Planta Med. 2003;69:559-61 pubmed
    Prenylated flavonoids containing the resorcinol moiety were isolated as tyrosinase inhibitors from the roots of Sophora flavescens by activity-guided fractionation...
  38. Xu Z, Tang M, Chen H, Ban Y, Zhang H. Microbial community structure in the rhizosphere of Sophora viciifolia grown at a lead and zinc mine of northwest China. Sci Total Environ. 2012;435-436:453-64 pubmed publisher
    ..In this study, we investigated arbuscular mycorrhizal (AM) fungi and bacteria associated with Sophora viciifolia growing at a lead and zinc mine in Qinling Mountain, China...
  39. Lee S, Lee H, Nam J, Kwon O, Baek J, Chang J, et al. Kurarinone isolated from Sophora flavescens Ait inhibited MCP-1-induced chemotaxis. J Ethnopharmacol. 2005;97:515-9 pubmed
    ..natural sources, we isolated one active compound through active-guided fractionations from the MeOH extracts of Sophora flavescens Ait (Leguminosae)...
  40. Chen L, Cheng X, Shi W, Lu Q, Go V, Heber D, et al. Inhibition of growth of Streptococcus mutans, methicillin-resistant Staphylococcus aureus, and vancomycin-resistant enterococci by kurarinone, a bioactive flavonoid isolated from Sophora flavescens. J Clin Microbiol. 2005;43:3574-5 pubmed
  41. Zhou Y, Shan H, Qiao G, Sui X, Lu Y, Yang B. Inotropic effects and mechanisms of matrine, a main alkaloid from Sophora flavescens AIT. Biol Pharm Bull. 2008;31:2057-62 pubmed
    ..In a conclusion, ICa-L might be a main target of matrine. Matrine enhanced [Ca2+]i by stimulating ICa-L and exerted positive inotropic effects on electrically driven guinea pig papillary muscles...
  42. Liu S, Li Q, Chen X, Hu Z. Field-amplified sample stacking in capillary electrophoresis for on-column concentration of alkaloids in Sophora flavescens Ait. Electrophoresis. 2002;23:3392-7 pubmed
    ..and rapid capillary zone electrophoresis method was developed for the separation of the main alkaloids from Sophora flavescens Ait. with the optimum buffer solution containing 110 mM NaH(2)PO(4) and 15% 2-propanol (pH 3.0)...
  43. Wang H, Lu Y, Chen J, Li J, Liu S. Subcritical water extraction of alkaloids in Sophora flavescens Ait. and determination by capillary electrophoresis with field-amplified sample stacking. J Pharm Biomed Anal. 2012;58:146-51 pubmed publisher
    The extraction and determination of cytisine, sophocarpine, matrine, sophoridine and oxymatrine in Sophora flavescens Ait...
  44. Lai J, He X, Jiang Y, Chen F. Preparative separation and determination of matrine from the Chinese medicinal plant Sophora flavescens Ait by molecularly imprinted solid-phase extraction. Anal Bioanal Chem. 2003;375:264-9 pubmed
    ..SPE) and as chromatographic stationary phase for the determination of MT from the Chinese medicinal plant Sophora flavescens...
  45. Berghe W, De Naeyer A, Dijsselbloem N, David J, De Keukeleire D, Haegeman G. Attenuation of ERK/RSK2-driven NF?B gene expression and cancer cell proliferation by kurarinone, a lavandulyl flavanone isolated from Sophora flavescens ait. roots. Endocr Metab Immune Disord Drug Targets. 2011;11:247-61 pubmed
    We have analyzed in molecular detail how kurarinone, a lavandulyl flavanone isolated from Sophora flavescens, suppresses nuclear factor-?B (NF?B)-driven interleukin-6 (IL6) expression and cancer cell growth...
  46. Ding P, Liao Z, Huang H, Zhou P, Chen D. (+)-12alpha-Hydroxysophocarpine, a new quinolizidine alkaloid and related anti-HBV alkaloids from Sophora flavescens. Bioorg Med Chem Lett. 2006;16:1231-5 pubmed
    12alpha-Hydroxysophocarpine (8), a new quinolizidine alkaloid was isolated from the roots of Sophora flavescens, together with 10 known quinolizidine alkaloids, (+)-oxymatrine (1), (+)-matrine (2), (+)-9alpha-hydroxymatrine (3), (+)-..
  47. Piao X, Piao X, Kim S, Park J, Kim H, Cai S. Identification and characterization of antioxidants from Sophora flavescens. Biol Pharm Bull. 2006;29:1911-5 pubmed
    The objectives of this study were to investigate the radical-scavenging activity and protective potential of Sophora flavescens from oxidative damage by the radical generator 2,2'-azobis(2-amidinopropane)dihydrochloride (AAPH) in renal ..
  48. Lee J, Baek N, Kim S, Park H, Yang J, Lee J, et al. A new cytotoxic prenylated chalcone from Sophora flavescens. Arch Pharm Res. 2007;30:408-11 pubmed
    We have isolated a new prenylated chalcone from the roots of Sophora flavescens (Leguminosae)...
  49. Liu Z, Liu B, Zhang Z, Zhou T, Bian H, Min M, et al. A mannose-binding lectin from Sophora flavescens induces apoptosis in HeLa cells. Phytomedicine. 2008;15:867-75 pubmed publisher
    The objective of this study was to investigate the anti-tumor activity of a lectin from Sophora flavescens and explore its potential apoptotic induction mechanism...
  50. Jung H, Yoon N, Kang S, Kim Y, Choi J. Inhibitory activities of prenylated flavonoids from Sophora flavescens against aldose reductase and generation of advanced glycation endproducts. J Pharm Pharmacol. 2008;60:1227-36 pubmed publisher
    ..Here we evaluate the inhibitory activities of prenylated flavonoids isolated from Sophora flavescens, a traditional herbal medicine, on rat lens AR (RLAR), human recombinant AR (HRAR) and AGE formation...
  51. Jin H, Lv J, Chen S. Paenibacillus sophorae sp. nov., a nitrogen-fixing species isolated from the rhizosphere of Sophora japonica. Int J Syst Evol Microbiol. 2011;61:767-71 pubmed publisher
    A nitrogen-fixing bacterium, designated strain S27(T), was isolated from rhizosphere soil of Sophora japonica...
  52. Hwang E, Ryu Y, Kim H, Kim D, Hong S, Lee J, et al. BACE1 inhibitory effects of lavandulyl flavanones from Sophora flavescens. Bioorg Med Chem. 2008;16:6669-74 pubmed publisher
    ..In this study, lipophilic alkylated (C(10)-C(5)) flavanones from Sophora flavescens were examined for their inhibitory effects against beta-secretase...
  53. Lin Z, Huang C, Liu X, Jiang J. In vitro anti-tumour activities of quinolizidine alkaloids derived from Sophora flavescens Ait. Basic Clin Pharmacol Toxicol. 2011;108:304-9 pubmed publisher
    The dry root of Sophora flavescens Ait. (SF) has long been used in a variety of Chinese herbal formulations to treat patients with cancer. Alkaloids are commonly known to present in SF as main active constituents...
  54. Hillerns P, Wink M. Binding of flavonoids from Sophora flavescens to the rat uterine estrogen receptor. Planta Med. 2005;71:1065-8 pubmed
    Prenylflavonoids and lavandulylflavonoids were isolated from the roots of Sophora flavescens Aiton (Fabaceae)...
  55. Lao C, Lin J, Kuo J, Chao P, Cheng C, Tang N, et al. Microglia, apoptosis and interleukin-1beta expression in the effect of sophora japonica l. on cerebral infarct induced by ischemia-reperfusion in rats. Am J Chin Med. 2005;33:425-38 pubmed
    b>Sophora Japonica L. (SJ) is a traditional Chinese herb used to cool blood, stop bleeding and to treat hemorrhoids with bleeding...
  56. Banko P, Cipollini M, Breton G, Paulk E, Wink M, Izhaki I. Seed chemistry of Sophora chrysophylla (mamane) in relation to diet of specialist avian seed predator Loxioides bailleui (palila) in Hawaii. J Chem Ecol. 2002;28:1393-410 pubmed
    ..the chemical ecology of a tritrophic interaction among species endemic to the island of Hawaii, USA: a tree (Sophora chrysophylla: mamane), an endangered bird (Loxioides bailleui; palila), and moth larvae (Cydia spp.)...
  57. Wang L, Li F, Lu J, Li G, Li D, Zhong X, et al. The Chinese herbal medicine Sophora flavescens activates pregnane X receptor. Drug Metab Dispos. 2010;38:2226-31 pubmed publisher
    b>Sophora flavescens (SF) is an herbal medicine widely used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage, and skin diseases. It was recently reported that SF up-regulates CYP3A expression...
  58. Lee W, Tokuoka T, Heo K. Molecular evidence for the inclusion of the Korean endemic genus " Echinosophora" in Sophora (Fabaceae), and embryological features of the genus. J Plant Res. 2004;117:209-19 pubmed
    ..of Papillionoideae of Fabaceae in Korea, it has been controversial whether it is distinct from or merged with Sophora. To resolve this matter, we conducted molecular phylogenetic analyses using nucleotide sequence data from the ..