psoralea

Summary

Summary: A plant genus of the family FABACEAE that is a source of psoralen (FICUSIN).

Top Publications

  1. Liu R, Li A, Sun A, Kong L. Preparative isolation and purification of psoralen and isopsoralen from Psoralea corylifolia by high-speed counter-current chromatography. J Chromatogr A. 2004;1057:225-8 pubmed
    Psoralen and isopsoralen were separated from Psoralea corylifolia by high-speed counter-current chromatography (HSCCC). A two-phase solvent system composed of n-hexane-ethyl acetate-methanol-water (5:5:4.5:5...
  2. Mar W, Je K, Seo E. Cytotoxic constituents of Psoralea corylifolia. Arch Pharm Res. 2001;24:211-3 pubmed
    A coumestan derivative, psoralidin (1) was found to be a cytotoxic principle of the seeds of Psoralea corylifolia L. (Leguminosae) with the IC50 values of 0.3 and 0...
  3. Zhao L, Wu M, Xiang B. Analysis of Psoralea corylifolia L. fruits in different regions. Chem Pharm Bull (Tokyo). 2005;53:1054-7 pubmed
    ..It was shown that the samples could be clustered reasonably into three groups, hence corresponding with the typical habitats of Psoralea corylifolia L.
  4. Chen Y, Wang H, Xia X, Kung H, Pan Y, Kong L. Behavioral and biochemical studies of total furocoumarins from seeds of Psoralea corylifolia in the chronic mild stress model of depression in mice. Phytomedicine. 2007;14:523-9 pubmed
    ..The seeds of Psoralea corylifolia, otherwise known as Buguzhi, have long been used for treatments of various symptoms associated with ..
  5. Szliszka E, Czuba Z, Sędek Ł, Paradysz A, Krol W. Enhanced TRAIL-mediated apoptosis in prostate cancer cells by the bioactive compounds neobavaisoflavone and psoralidin isolated from Psoralea corylifolia. Pharmacol Rep. 2011;63:139-48 pubmed
    ..The data indicate the potential role of the bioactive compounds isolated from the medicinal plant Psoralea corylifolia (neobavaisoflavone and psoralidin) in prostate cancer chemoprevention through enhancement of TRAIL-..
  6. Dua V, Kumar A, Pandey A, Kumar S. Insecticidal and genotoxic activity of Psoralea corylifolia Linn. (Fabaceae) against Culex quinquefasciatus Say, 1823. Parasit Vectors. 2013;6:30 pubmed publisher
    ..In the present study the larvicidal, adulticidal and genotoxic activity of essential oil of Psoralea corylifolia Linn. against Culex quinquefasciatus Say was explored.
  7. Wong R, Rabie A. Effect of Buguzhi (Psoralea corylifolia fruit) extract on bone formation. Phytother Res. 2010;24 Suppl 2:S155-60 pubmed publisher
    The objective of the study is to compare the amount of new bone produced by Buguzhi (Psoralea corylifolia fruit) extract in collagen matrix to that produced and collagen matrix in vivo...
  8. Choi Y, Yon G, Hong K, Yoo D, Choi C, Park W, et al. In vitro BACE-1 inhibitory phenolic components from the seeds of Psoralea corylifolia. Planta Med. 2008;74:1405-8 pubmed publisher
    A new isoflavone, neocorylin ( 1) was isolated from the seeds extract of Psoralea corylifolia L. (Fabaceae), together with eight known constituents ( 2 - 9), i. e...
  9. Lee M, Kim J, Ryu J. Prenylflavones from Psoralea corylifolia inhibit nitric oxide synthase expression through the inhibition of I-kappaB-alpha degradation in activated microglial cells. Biol Pharm Bull. 2005;28:2253-7 pubmed
    ..From the methanol extracts of Psoralea corylifolia, we purified two inhibitors of NO production in lipopolysaccharide (LPS)-activated microglia by ..

More Information

Publications80

  1. Lee S, Yun B, Kim M, Park C, Lee W, Oh H, et al. Phenolic compounds isolated from Psoralea corylifolia inhibit IL-6-induced STAT3 activation. Planta Med. 2012;78:903-6 pubmed publisher
    ..In this study, seven flavonoids were isolated from the methanol extracts of Psoralea corylifolia by bioactivity-guided fractionation...
  2. Xin D, Wang H, Yang J, Su Y, Fan G, Wang Y, et al. Phytoestrogens from Psoralea corylifolia reveal estrogen receptor-subtype selectivity. Phytomedicine. 2010;17:126-31 pubmed publisher
    The seed of Psoralea corylifolia L. (PCL), a well-known traditional Chinese medicine, has been applied as a tonic or an aphrodisiac agent and commonly used as a remedy for bone fracture, osteomalacia and osteoporosis in China...
  3. Haraguchi H, Inoue J, Tamura Y, Mizutani K. Antioxidative components of Psoralea corylifolia (Leguminosae). Phytother Res. 2002;16:539-44 pubmed
    A meroterpene and four flavonoids were isolated from the seeds of Psoralea corylifolia as antioxidative components...
  4. Yi L, Li Y, Pan Y, Li J, Xu Q, Mo S, et al. Antidepressant-like effects of psoralidin isolated from the seeds of Psoralea Corylifolia in the forced swimming test in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32:510-9 pubmed
    The antidepressant-like effects of psoralidin isolated from the seeds of Psoralea corylifolia were investigated in the forced swimming test (FST) in ICR strain of male mice...
  5. Cho H, Jun J, Song E, Kang K, Baek H, Ko Y, et al. Bakuchiol: a hepatoprotective compound of Psoralea corylifolia on tacrine-induced cytotoxicity in Hep G2 cells. Planta Med. 2001;67:750-1 pubmed
    Bioassay-guided fractionation of the H(2)O extract of the seeds of Psoralea corylifolia furnished one hepatoprotective compound, bakuchiol (1), together with two moderately active compounds, bakuchicin (2) and psoralen (3), on tacrine-..
  6. Yang W, Chang M, Park S. Effects of Psoralea corylifolia on the cAMP-responsive element modulator (CREM) expression and spermatogenesis in rats. J Ethnopharmacol. 2008;117:503-6 pubmed publisher
    b>Psoralea corylifolia (PC) is a medicinal herb used to improve male reproductive function in Korean traditional medicine. It has been used for treatment of male infertility including sexual dysfunction by improving kidney function.
  7. Khatune N, Islam M, Haque M, Khondkar P, Rahman M. Antibacterial compounds from the seeds of Psoralea corylifolia. Fitoterapia. 2004;75:228-30 pubmed
    Psoralidin, bakuchicin, psoralin and angelicin, isolated from the seeds of Psoralea corylifolia, showed significant antibacterial activities against a number of Gram (+) and Gram (-) bacteria.
  8. Rajendra Prasad N, Anandi C, Balasubramanian S, Pugalendi K. Antidermatophytic activity of extracts from Psoralea corylifolia (Fabaceae) correlated with the presence of a flavonoid compound. J Ethnopharmacol. 2004;91:21-4 pubmed
    Extracts obtained from seeds of Psoralea corylifolia showed several degrees of antifungal activity against Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum and Microsporum gypseum by the disc diffusion method on ..
  9. Yin S, Fan C, Wang Y, Dong L, Yue J. Antibacterial prenylflavone derivatives from Psoralea corylifolia, and their structure-activity relationship study. Bioorg Med Chem. 2004;12:4387-92 pubmed
    ..new prenylflavonoids, namely corylifols A-C (1-3), together with 13 known ones, were isolated from the seeds of Psoralea corylifolia. Their structures were elucidated by spectral methods including 1D and 2D NMR techniques...
  10. Lim S, Ha T, Ahn J, Kim S. Estrogenic activities of Psoralea corylifolia L. seed extracts and main constituents. Phytomedicine. 2011;18:425-30 pubmed publisher
    Estrogenic activities of ethanol extract and its active components from Psoralea corylifolia L. were studied using various in vitro assays...
  11. Zhao G, Zheng X, Qin G, Gai Y, Jiang Z, Guo L. In vitro dopaminergic neuroprotective and in vivo antiparkinsonian-like effects of Delta 3,2-hydroxybakuchiol isolated from Psoralea corylifolia (L.). Cell Mol Life Sci. 2009;66:1617-29 pubmed publisher
    Cocktail recipes containing Psoralea corylifolia seeds (PCS) are used to empirically treat Parkinson disease...
  12. Backhouse C, Delporte C, Negrete R, Erazo S, Zuniga A, Pinto A, et al. Active constituents isolated from Psoralea glandulosa L. with antiinflammatory and antipyretic activities. J Ethnopharmacol. 2001;78:27-31 pubmed
    ..the petroleum ether extract (PEE), dichloromethane extract (DME) and methanol extract (ME1) of the aerial part of Psoralea glandulosa L. (Papilionaceae) were studied...
  13. Lim S, Ha T, Kim S, Ahn J, Park H, Kim S. Ethanol extract of Psoralea corylifolia L. and its main constituent, bakuchiol, reduce bone loss in ovariectomised Sprague-Dawley rats. Br J Nutr. 2009;101:1031-9 pubmed publisher
    The aim of the present study was to investigate whether ethanol extracts of Psoralea corylifolia L. (PCE) and its active component protect against bone loss in ovariectomised rats...
  14. Jan S, Parween T, Siddiqi T, Mahmooduzzafar -. Anti-oxidant modulation in response to gamma radiation induced oxidative stress in developing seedlings of Psoralea corylifolia L. J Environ Radioact. 2012;113:142-9 pubmed publisher
    The seeds of Psoralea corylifolia L., an important medicinal herb in Indian and Chinese Pharmacopeia were exposed to gamma rays (2.5, 5, 10, 15 and 20 kGy) from Co(60) source at dose rate of 1.65 kGy h(-1)...
  15. Kim Y, Oh H, Kim B, Kang T, Ko E, Han Y, et al. In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia. Planta Med. 2005;71:87-9 pubmed
    ..Bioassay-guided fractionation of the EtOAc-soluble extract of the seeds of Psoralea corylifolia afforded two protein tyrosine phosphatase 1B inhibitory compounds, psoralidin (1) and bakuchiol (2), ..
  16. Yang X, Li J, Wang X, Fang W, Bidochka M, She R, et al. Psc-AFP, an antifungal protein with trypsin inhibitor activity from Psoralea corylifolia seeds. Peptides. 2006;27:1726-31 pubmed
    ..with an apparent molecular mass of 18kDa, was isolated from a traditional Chinese herb, malaytea scurfpea (Psoralea corylifolia L.)...
  17. Qiao C, Han Q, Mo S, Song J, Xu L, Chen S, et al. Psoralenoside and isopsoralenoside, two new benzofuran glycosides from Psoralea corylifolia. Chem Pharm Bull (Tokyo). 2006;54:714-6 pubmed
    Two new benzofuran glycosides, called psoralenoside and isopsoralenoside, were isolated from the fruits of Psoralea corylifolia, together with nine known compounds...
  18. Shinde A, Malpathak N, Fulzele D. Studied enhancement strategies for phytoestrogens production in shake flasks by suspension culture of Psoralea corylifolia. Bioresour Technol. 2009;100:1833-9 pubmed publisher
    ..and nitrogen on growth and production of phytoestrogens daidzein and genistein by suspension cultures of Psoralea corylifolia was investigated for the first time...
  19. Ruan B, Kong L, Takaya Y, Niwa M. Studies on the chemical constituents of Psoralea corylifolia L. J Asian Nat Prod Res. 2007;9:41-4 pubmed
    ..A (4), neobavaisoflavone (5), daidzin (6) and uracil (7), have been isolated from the dried fruits of Psoralea corylifolia L...
  20. Misra P, Pandey A, Tewari S, Nath P, Trivedi P. Characterization of isoflavone synthase gene from Psoralea corylifolia: a medicinal plant. Plant Cell Rep. 2010;29:747-55 pubmed publisher
    ..and functionally characterized an isoflavones synthase (IFS) gene from a traditionally acclaimed medicinal plant Psoralea corylifolia abundantly growing in tropical and subtropical regions...
  21. Park E, Zhao Y, Kim Y, Sohn D. Protective effect of (S)-bakuchiol from Psoralea corylifolia on rat liver injury in vitro and in vivo. Planta Med. 2005;71:508-13 pubmed
    The aim of this study was to investigate the protective effect of (S)-bakuchiol isolated from the seed of Psoralea corylifolia, on liver injury...
  22. Matsuda H, Sugimoto S, Morikawa T, Matsuhira K, Mizuguchi E, Nakamura S, et al. Bioactive constituents from Chinese natural medicines. XX. Inhibitors of antigen-induced degranulation in RBL-2H3 cells from the seeds of Psoralea corylifolia. Chem Pharm Bull (Tokyo). 2007;55:106-10 pubmed
    The ethyl acetate-soluble fraction of the methanolic extract from the seeds of Psoralea corylifolia was found to inhibit the release of beta-hexosaminidase, as a marker of antigen-IgE-induced degranulation in RBL-2H3 cells...
  23. Qiao C, Han Q, Song J, Mo S, Kong L, Kung H, et al. Chemical fingerprint and quantitative analysis of fructus psoraleae by high-performance liquid chromatography. J Sep Sci. 2007;30:813-8 pubmed
    ..A more comprehensive analytical method was established for the fingerprint of Fructus Psoraleae. It is very useful for authentication and quality assessment of the crude drug...
  24. Tsai M, Huang G, Hung Y, Bin L, Liao L, Lin L. Psoralea corylifolia extract ameliorates experimental osteoporosis in ovariectomized rats. Am J Chin Med. 2007;35:669-80 pubmed
    We evaluated the protective effect of Psoralea corylifolia L. (PCL) extract on the ovariectomized (OVX) rat model. The biochemical markers of bone turnover, calcium metabolism, and calcium balance were examined...
  25. Takizawa T, Mitsumori K, Takagi H, Nasu M, Yasuhara K, Onodera H, et al. Sequential analysis of testicular lesions and serum hormone levels in rats treated with a Psoralea corylifolia extract. Food Chem Toxicol. 2004;42:1-7 pubmed
    In order to clarify pathogenetic targets for the testicular toxicity of a extract of Psoralea corylifolia (P. corylifolia), F344 rats were fed diet containing 3% P...
  26. Newton S, Lau C, Gurcha S, Besra G, Wright C. The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis. J Ethnopharmacol. 2002;79:57-67 pubmed
    ..aurum were comparable with those against M. bovis BCG with compound (2) being the most active (M. bovis BCG, IC(50)=14.3 microg/ml [37.3 microM]). These results support the use of these plants in traditional medicine...
  27. Feng L, Wang L, Jiang X. Pharmacokinetics, tissue distribution and excretion of coumarin components from Psoralea corylifolia L. in rats. Arch Pharm Res. 2010;33:225-30 pubmed publisher
    Coumarin components from Psoralea corylifolia L. are novel drugs in which psoralen and isopsoralen are the active components...
  28. Xu Q, Pan Y, Yi L, Li Y, Mo S, Jiang F, et al. Antidepressant-like effects of psoralen isolated from the seeds of Psoralea corylifolia in the mouse forced swimming test. Biol Pharm Bull. 2008;31:1109-14 pubmed
    ..The behavioral and biochemical effects of psoralen, a major furocoumarin isolated from Psoralea corylifolia, were investigated in the FST model of depression in male mice...
  29. Chen Y, Kong L, Xia X, Kung H, Zhang L. Behavioral and biochemical studies of total furocoumarins from seeds of Psoralea corylifolia in the forced swimming test in mice. J Ethnopharmacol. 2005;96:451-9 pubmed
    The behavioral and biochemical effects of total furocoumarins from seeds of Psoralea corylifolia (TFPC) were investigated in the forced swimming test (FST) in mice in comparison with amitriptyline and fluoxetine...
  30. Wang D, Li F, Jiang Z. Osteoblastic proliferation stimulating activity of Psoralea corylifolia extracts and two of its flavonoids. Planta Med. 2001;67:748-9 pubmed
    b>Psoralea corylifolia L. fruit extracts exhibited osteoblastic proliferation stimulating activity in UMR106 cell line cultured in vitro...
  31. Guo Y, Jia T, Lin G. [Study on micro-wave processed of Psoralea corylifolia with uniform and regression analysis]. Zhongguo Zhong Yao Za Zhi. 2007;32:1167-70 pubmed
    ..the herb processing process for the total contains of psoralen and isopsoralen and the rate of extract in Psoralea corylifolia by micro-wave herb processing. The contains of psoralen and isopsoralen was obtained by HPLC...
  32. Ren Y, Qin Y, Zheng L, Dai X, Tao L, Chen Y, et al. [Electron microscopical observation on rats with Pneumocystis carinii pneumonia treated with Brucea javanica and Fructus Psoraleae]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2006;24:473-5 pubmed
    ..The results show that a combination of Brucea javanica and Fructus Psoraleae played a significant restraining and killing effect on cysts, and helped repair the impairment of pneumonia. ..
  33. Shoji M, Arakaki Y, Esumi T, Kohnomi S, Yamamoto C, Suzuki Y, et al. Bakuchiol Is a Phenolic Isoprenoid with Novel Enantiomer-selective Anti-influenza A Virus Activity Involving Nrf2 Activation. J Biol Chem. 2015;290:28001-17 pubmed publisher
    ..Bakuchiol is a phenolic isoprenoid compound present in Babchi (Psoralea corylifolia L.) seeds...
  34. Alam F, Khan G, Asad M. Psoralea corylifolia L: Ethnobotanical, biological, and chemical aspects: A review. Phytother Res. 2017;: pubmed publisher
    b>Psoralea corylifolia L. (Leguminosae) is a well-known traditional medicinal plant used from ancient times for treatment of various ailments...
  35. Song P, Yang X, Yuan J. Cytotoxic constituents from Psoralea corylifolia. J Asian Nat Prod Res. 2013;15:624-30 pubmed publisher
    Bioassay directed isolation of the EtOAc extract from a traditional Chinese medicine Psoralea corylifolia resulted in the purification of two isoflavonoids, corylifols D (1) and E (2), along with four known ones...
  36. Vardhan P, Shukla L. Gamma irradiation of medicinally important plants and the enhancement of secondary metabolite production. Int J Radiat Biol. 2017;93:967-979 pubmed publisher
    ..compounds increase with ?-irradiation in whole plants/plant parts; psoralen content in the common herb babchi (Psoralea corylifolia) was increased as high as 32-fold with ?-irradiation of seeds at 20 kGy...
  37. Yan Y, Liao H, Guo L. [Study on the extraction process of total flavonoids from Psoralea corylifolia by enzyme-assisted technique]. Zhong Yao Cai. 2012;35:1144-7 pubmed
    To study the optimum extraction process of total flavonoids from Psoralea coryl folia by cellulose-assisted technique...
  38. Feng J, Yang Y, Zhou Y, Wang B, Xiong H, Fan C, et al. Bakuchiol attenuates myocardial ischemia reperfusion injury by maintaining mitochondrial function: the role of silent information regulator 1. Apoptosis. 2016;21:532-45 pubmed publisher
    ..Bakuchiol (BAK), an analog of resveratrol and a monoterpene phenol isolated from the seeds of Psoralea corylifolia (Leguminosae), protects tissues from injury...
  39. Kim D, Li H, Han Y, Jeong J, Lee H, Ryu J. Modulation of Inducible Nitric Oxide Synthase Expression in LPS-Stimulated BV-2 Microglia by Prenylated Chalcones from Cullen corylifolium (L.) Medik. through Inhibition of I-κBα Degradation. Molecules. 2018;23: pubmed publisher
    ..From the activity-guided purification of Cullen corylifolium (L.) Medik. (syn. Psoralea corylifolia L...
  40. Pae H, Cho H, Oh G, Kim N, Song E, Kim Y, et al. Bakuchiol from Psoralea corylifolia inhibits the expression of inducible nitric oxide synthase gene via the inactivation of nuclear transcription factor-kappaB in RAW 264.7 macrophages. Int Immunopharmacol. 2001;1:1849-55 pubmed
  41. Arora R, Dhaker A, Adhikari M, Sharma J, Chawla R, Gupta D, et al. Radical scavenging and radiomodulatory effects of Psoralea corylifolia Linn. substantiated by in vitro assays and EPR spectroscopy. Z Naturforsch C. 2011;66:35-46 pubmed
    The present study is the first report of the radiomodulatory effects of Psoralea corylifolia Linn. The extract (IBG-RA-26) prepared from P. corylifolia was chemically analysed by HPLC, LC-MS/MS and NMR...
  42. Jan S, Parween T, Siddiqi T, Mahmooduzzafar -. Enhancement in furanocoumarin content and phenylalanine ammonia lyase activity in developing seedlings of Psoralea corylifolia L. in response to gamma irradiation of seeds. Radiat Environ Biophys. 2012;51:341-7 pubmed publisher
    ..Furanocoumarin content was estimated in seeds of Psoralea corylifolia L...
  43. Yang Y, Zhang Y, Chen Z, Zhang Y, Yang X. Plasma pharmacokinetics and cerebral nuclei distribution of major constituents of Psoraleae fructus in rats after oral administration. Phytomedicine. 2018;38:166-174 pubmed publisher
    The fruit of Psoralea corylifolia L., Psoraleae fructus (PF), is widely used in traditional Chinese medicine as a well-known herbal tonic...
  44. Wei S, Yan Z, Zhou J. Psoralea corylifolia protects against testicular torsion/detorsion-induced ischemia/reperfusion injury. J Ethnopharmacol. 2011;137:568-74 pubmed publisher
    ..The transcription factor cAMP-responsive element modulator-? (CREM?) plays an essential role in spermatogenesis. Psoralea corylifolia, a medicinal herb with anti-oxidative activity, has been used to treat male reproductive dysfunction ..
  45. Yang T, Qin M. [Isolation and structure identification of a new isoflavone from Psoralea corylifolias]. Yao Xue Xue Bao. 2006;41:76-9 pubmed
    To study the chemical constituents of the fruits of Psoralea corylifolia L. The constituents were separated and purified by column chromatography with normal phase silica gel and polyamide...
  46. Weng Z, Gao Q, Wang F, Zhao G, Yin F, Cai B, et al. Positive skeletal effect of two ingredients of Psoralea corylifolia L. on estrogen deficiency-induced osteoporosis and the possible mechanisms of action. Mol Cell Endocrinol. 2015;417:103-13 pubmed publisher
    ..b>Psoralea corylifolia L. has long been used as tonic and food additives in many countries...
  47. Liu H, Bai Y, Chen Y, Zhao Y. [Studies on chemical constituents from seed of Psoralea corylifolia]. Zhongguo Zhong Yao Za Zhi. 2008;33:1410-2 pubmed
    To study the chemical constituents of Psoralea corylifolia. Chromatographic methods were used to separate compounds, and spectroscopic methods were used to determine the structures...
  48. Ali S, Mahmooduzzafar -, Abdin M, Iqbal M. Ontogenetic changes in foliar features and psoralen content of Psoralea corylifolia Linn. exposed to SO2 stress. J Environ Biol. 2008;29:661-8 pubmed
    Field-grown Psoralea corylifolia plants were exposed to 0.5 ppm and 1.0 ppm concentrations of sulphur dioxide gas and sampled for observation at the pre-flowering, flowering and post-flowering stages of plant ontogeny...
  49. Li X, Lee Y, Kim Y, Jeong G, Cui H, Kim H, et al. Bakuchicin induces vascular relaxation via endothelium-dependent NO-cGMP signaling. Phytother Res. 2011;25:1574-8 pubmed publisher
    Bakuchicin is a furanocoumarin derived from the seeds of Psoralea corylifolia. The aim of the present study was to investigate the effect of bakuchicin on vascular tone in rat aortic tissue...
  50. Ming L, Cheng K, Ge B, Ma H, Zai Y. [Effect of isopsoralen on the proliferation and differentiate of osteoblasts in vitro]. Zhong Yao Cai. 2011;34:404-8 pubmed
    ..To investigate the effect of isopsoralen on proliferation, osteogenic differentiation and calcification capacity of rat calvarial osteoblasts (ROB)...
  51. Xiu Y, Shi B, Pan L, Wang J, Zhang D. [Study on tissue distribution of psoraleae fructus decoction in rats]. Zhongguo Zhong Yao Za Zhi. 2013;38:1242-6 pubmed
    ..05). MRT(0-t) of both psoralen and isopsoralen were about 10 h. Therefore, psoralen and isopsoralen showed stronger targeting selection in liver, kidney and lung...
  52. Chen X, Yang Y, Zhang Y. Isobavachalcone and bavachinin from Psoraleae Fructus modulate A?42 aggregation process through different mechanisms in vitro. FEBS Lett. 2013;587:2930-5 pubmed publisher
    ..Both of the compounds attenuated A?42-induced toxicity in a SH-SY5Y cell model. These findings may provide valuable information for new drug development and Alzheimer's therapy in the future. ..
  53. Park C, Lee Y, Chang E, Lee M, Yoon J, Ryu J, et al. Bavachalcone inhibits osteoclast differentiation through suppression of NFATc1 induction by RANKL. Biochem Pharmacol. 2008;75:2175-82 pubmed publisher
    ..Bavachalcone was isolated from Psoralea corylifolia, and its effects on osteoclast differentiation were evaluated with primary cultures of osteoclast ..
  54. Liu Z, Zhang X, Zhao S, Zhou R. [Extraction and purification of psoralen from Psoralea corylifolia L]. Di Yi Jun Yi Da Xue Xue Bao. 2005;25:751-2 pubmed
    To establish a method for extracting psoralen from the seed of Psoralea corylifolia L.
  55. Li Z, Abulizi A, Zhao G, Wang T, Zhou F, Jiang Z, et al. Bakuchiol Contributes to the Hepatotoxicity of Psoralea corylifolia in Rats. Phytother Res. 2017;31:1265-1272 pubmed publisher
    b>Psoralea corylifolia L. (Fructus Psoraleae) is widely used in Asia, but there are concerns about hepatotoxicity caused by constituents such as psoralens and bakukiol...
  56. Zhang H, Zhu J, Qi S, Chen X, Hu Z. Separation and determination of psoralen and isopsoralen by microemulsion electrokinetic chromatography. Biomed Chromatogr. 2007;21:1083-7 pubmed
    The use of microemulsion electrokinetic chromatography was proposed to separate psoralen and isopsoralen in Psoralea corylitolia L. and its preparations...
  57. Faiyazuddin M, Akhtar N, Akhter J, Suri S, Shakeel F, Shafiq S, et al. Production, characterization, in vitro and ex vivo studies of babchi oil-encapsulated nanostructured solid lipid carriers produced by a hot aqueous titration method. Pharmazie. 2010;65:348-55 pubmed
    ..33%), CAT (6.67%)], Tween 80 (9.25% v/v), transcutol-P (28.75% v/v) and distilled water (53% v/v). These results suggest that the studied SLN might be promising vehicles for babchi oil in the management of psoriasis...
  58. Madrid A, Espinoza L, Gonzalez C, Mellado M, Villena J, Santander R, et al. Antifungal study of the resinous exudate and of meroterpenoids isolated from Psoralea glandulosa (Fabaceae). J Ethnopharmacol. 2012;144:809-11 pubmed publisher
    b>Psoralea glandulosa L. (Fabaceae) is a medicinal resinous shrub used in Chilean folk medicine as antiseptic in treatment of infections and skin diseases caused by bacteria and fungus.
  59. Baskaran P, Jayabalan N. Psoralen production in hairy roots and adventitious roots cultures of Psoralea coryfolia. Biotechnol Lett. 2009;31:1073-7 pubmed publisher
    b>Psoralea corylifolia is an endangered plant producing various compounds of medical importance. Adventitious roots and hairy roots were induced in cultures prepared from hypocotyl explants...
  60. Sultan T, Ali S. Psoralea corylifolia extracts stimulate cholinergic-like psoralen receptors of tadpole-tail melanophores, leading to skin darkening. J Recept Signal Transduct Res. 2011;31:39-44 pubmed publisher
    The present work was carried out to determine the effects of lyophilized seed extracts of Psoralea corylifolia along with pure psoralen, its active ingredient on the isolated tail-piece melanophores of Bufo melanostictus, a type of ..
  61. Ling F, Lu C, Tu X, Yi Y, Huang A, Zhang Q, et al. Antiprotozoal screening of traditional medicinal plants: evaluation of crude extract of Psoralea corylifolia against Ichthyophthirius multifiliis in goldfish. Parasitol Res. 2013;112:2331-40 pubmed publisher
    ..The screening results showed that the methanol extract of Psoralea corylifolia had the highest activity against I. multifiliis theronts. In vivo theront trials demonstrated that 1...
  62. Qin Y, Cui Y, Ren Y, Zhang X, Wang Y, Zheng X, et al. [Immunological regulation and treatment of Brucea javanica and Fructus Psoraleae on rats with Pneumocystis carinii pneumonia]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2006;24:59-62 pubmed
    ..To study the immunological regulation and treatment of Brucea javanica and Fructus Psoraleae, traditional Chinese medicine, on rats with Pneumocystis carinii pneumonia (PCP)...
  63. Chen X, Kong L, Su X, Pan C, Ye M, Zou H. Integration of ion-exchange chromatography fractionation with reversed-phase liquid chromatography-atmospheric pressure chemical ionization mass spectrometer and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for isolati. J Chromatogr A. 2005;1089:87-100 pubmed
    An approach for the separation and identification of components in a traditional Chinese medicine Psoralea corylifolia was developed. Ion-exchange chromatography (IEC) was applied for the fractionation of P...
  64. Jo J, Kim J, Lee H, Jeong G, Lee J, Lee S. Investigation of pharmacokinetic parameters of bakuchicin isolated from Psoralea corylifolia in mice. Fitoterapia. 2017;120:194-198 pubmed publisher
    Bakuchicin is a furanocoumarin isolated from the seeds of Psoralea corylifolia, which is used in oriental medicine...
  65. Cheung W, Tse M, Ngan T, Lin J, Lee W, Poon W, et al. Liver injury associated with the use of Fructus Psoraleae (Bol-gol-zhee or Bu-gu-zhi) and its related proprietary medicine. Clin Toxicol (Phila). 2009;47:683-5 pubmed publisher
    ..In summary, FP is associated with hepatotoxicity in some individuals. Pharmacovigilance for the potential side effects of herbal products is necessary...
  66. Qamaruddin -, Parveen N, Khan N, Singhal K. Potential antifilarial activity of the leaves and seeds extracts of Psoralea corylifolia on cattle filarial parasite Setaria cervi. J Ethnopharmacol. 2002;82:23-8 pubmed
    The effect of aqueous and alcohol extracts of the leaves and seeds of Psoralea corylifolia, on the spontaneous movements of both the whole worm and the nerve muscle preparation of Setaria cervi and on the survival of microfilariae in ..
  67. Wong R, Rabie A. Systemic effect of Fructus Psoraleae extract on bone in mice. Phytother Res. 2010;24:1578-80 pubmed publisher
    ..8%. The bone trabeculae increased by 7.1% in thickness so that the bone density was increased. To conclude, Fructus Psoraleae extract taken orally increases bone density and alters bone histomorphology...
  68. Jeong D, Watari K, Shirouzu T, Ono M, Koizumi K, Saiki I, et al. Studies on lymphangiogenesis inhibitors from Korean and Japanese crude drugs. Biol Pharm Bull. 2013;36:152-7 pubmed
    ..These compounds might offer clinical benefits as lymphangiogenesis inhibitors and may be good candidates for novel anti-cancer and anti-metastatic agents...
  69. Xu M, Tian X, Leung K, Lee K, Chow T, Deng B, et al. Embryotoxicity of Psoralea corylifolia L.: in vivo and in vitro studies. Birth Defects Res B Dev Reprod Toxicol. 2012;95:386-94 pubmed publisher
    b>Psoralea corylifolia L. (PC) was commonly used to treat miscarriages clinically. The aim of this study was to examine its embryotoxicity in mice and embryonic stem cells (ESCs).
  70. Siu W, Wong H, Lau C, Shum W, Wong C, Gao S, et al. The effects of an antiosteoporosis herbal formula containing epimedii herba, ligustri lucidi fructus and psoraleae fructus on density and structure of rat long bones under tail-suspension, and its mechanisms of action. Phytother Res. 2013;27:484-92 pubmed publisher
    ..Our study presents the first scientific evidence that ELP had a significant preventive effect against bone loss induced by TS through the actions of enhancing osteogenesis, suppressing adipogenesis and osteoclastogenesis...
  71. Liu Z, Lu C, Chen J. [Correlation comparison of uterotrophic assay and E-SCREEN assay for estrogenic activities]. Wei Sheng Yan Jiu. 2004;33:458-60 pubmed