glycyrrhiza uralensis

Summary

Summary: A plant species of the family FABACEAE.

Top Publications

  1. Jo E, Hong H, Ahn N, Jung J, Yang S, Park J, et al. Modulations of the Bcl-2/Bax family were involved in the chemopreventive effects of licorice root (Glycyrrhiza uralensis Fisch) in MCF-7 human breast cancer cell. J Agric Food Chem. 2004;52:1715-9 pubmed
    ..In this study, licorice (Glycyrrhiza uralensis Fisch) root also inhibits cell proliferation in human breast cancer cell...
  2. Hu C, Liu H, Du J, Mo B, Qi H, Wang X, et al. Estrogenic activities of extracts of Chinese licorice (Glycyrrhiza uralensis) root in MCF-7 breast cancer cells. J Steroid Biochem Mol Biol. 2009;113:209-16 pubmed publisher
    Despite the wide use of Chinese licorice root (Glycyrrhiza uralensis) for the treatment of menopausal complaints, little is known on its potential estrogenic properties, and available information relative to its effects on cell ..
  3. Zhang Q, Ye M. Chemical analysis of the Chinese herbal medicine Gan-Cao (licorice). J Chromatogr A. 2009;1216:1954-69 pubmed publisher
    Gan-Cao, or licorice, is a popular Chinese herbal medicine derived from the dried roots and rhizomes of Glycyrrhiza uralensis, G. glabra, and G. inflata...
  4. Wu T, Khor T, Saw C, Loh S, Chen A, Lim S, et al. Anti-inflammatory/Anti-oxidative stress activities and differential regulation of Nrf2-mediated genes by non-polar fractions of tea Chrysanthemum zawadskii and licorice Glycyrrhiza uralensis. AAPS J. 2011;13:1-13 pubmed publisher
    ..and differential regulation of Nrf2-mediated genes by tea Chrysanthemum zawadskii (CZ) and licorice Glycyrrhiza uralensis (LE) extracts...
  5. Mu Y, Zhang J, Zhang S, Zhou H, Toma D, Ren S, et al. Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in rats. J Pharmacol Exp Ther. 2006;316:1369-77 pubmed
    ..In this report, we show that two TCMs, Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch), and their selected constituents activate the xenobiotic orphan nuclear receptor pregnane X ..
  6. Choi E. Liquiritigenin isolated from Glycyrrhiza uralensis stimulates osteoblast function in osteoblastic MC3T3-E1 cells. Int Immunopharmacol. 2012;12:139-43 pubmed publisher
    ..These results demonstrate that liquiritigenin may have positive effects on skeletal structure...
  7. Cheng A, Wan F, Wang J, Jin Z, Xu X. Macrophage immunomodulatory activity of polysaccharides isolated from Glycyrrhiza uralensis Fish. Int Immunopharmacol. 2008;8:43-50 pubmed
    ..fraction of water-soluble polysaccharides, with estimated molecular weight of 10 kDa, was isolated from Glycyrrhiza uralensis Fish using ion exchange and size exclusion chromatography...
  8. Margaret Oliver I, Lei W, Parada M, Rodríguez Carvajal M, Crespo Rivas J, Hidalgo A, et al. Sinorhizobium fredii HH103 does not strictly require KPS and/or EPS to nodulate Glycyrrhiza uralensis, an indeterminate nodule-forming legume. Arch Microbiol. 2012;194:87-102 pubmed publisher
    ..HH103 mutants unable to produce KPS or exopolysaccharide (EPS) also showed reduced symbiotic capacity with Glycyrrhiza uralensis, an indeterminate nodule-forming legume...
  9. Zhang H, Liu J, Lu H, Gao S. Enhanced flavonoid production in hairy root cultures of Glycyrrhiza uralensis Fisch by combining the over-expression of chalcone isomerase gene with the elicitation treatment. Plant Cell Rep. 2009;28:1205-13 pubmed publisher
    ..The Glycyrrhiza uralensis Fisch cDNA encoding chalcone isomerase gene (chi) was over-expressed in hairy roots of G...

More Information

Publications85

  1. Liu Y, Yang J, Cai Z. Chemical investigation on Sijunzi decoction and its two major herbs Panax ginseng and Glycyrrhiza uralensis by LC/MS/MS. J Pharm Biomed Anal. 2006;41:1642-7 pubmed
    Sijunzi decoction consists of Panax ginseng, Poria cocos, Atractylodes macrocephala and Glycyrrhiza uralensis. High performance liquid chromatography coupled with tandem mass spectrometry (LC/MS(n)) was applied to identify and ..
  2. Li S, Li W, Wang Y, Asada Y, Koike K. Prenylflavonoids from Glycyrrhiza uralensis and their protein tyrosine phosphatase-1B inhibitory activities. Bioorg Med Chem Lett. 2010;20:5398-401 pubmed publisher
    ..9), isokaempferide (10), glycycoumarin (11), and isoglycycoumarin (12), were isolated from the roots of Glycyrrhiza uralensis and their structures were determined by extensive spectroscopic analyses...
  3. Wang W, Hu X, Zhao Z, Liu P, Hu Y, Zhou J, et al. Antidepressant-like effects of liquiritin and isoliquiritin from Glycyrrhiza uralensis in the forced swimming test and tail suspension test in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32:1179-84 pubmed publisher
    ..Test (TST) were used to evaluate the antidepressant activity of liquiritin and isoliquiritin from Glycyrrhiza uralensis in mice...
  4. Hennell J, Lee S, Khoo C, Gray M, Bensoussan A. The determination of glycyrrhizic acid in Glycyrrhiza uralensis Fisch. ex DC. (Zhi Gan Cao) root and the dried aqueous extract by LC-DAD. J Pharm Biomed Anal. 2008;47:494-500 pubmed publisher
    ..of glycyrrhizic acid in both the raw herb and a commercially prepared dried aqueous extract of Glycyrrhiza uralensis Fisch. ex DC. root (Zhi Gan Cao, liquorice)...
  5. Lee J, Ji Y, Yu M, Bo M, Seo H, Lee S, et al. Antimicrobial effect and resistant regulation of Glycyrrhiza uralensis on methicillin-resistant Staphylococcus aureus. Nat Prod Res. 2009;23:101-11 pubmed publisher
    In the present study, we investigated antimicrobial activity of Glycyrrhiza uralensis against various strains of methicillin-resistant Staphylococcus aureus (MRSA) (KCCM 11812, 40510, 40512)...
  6. Wang J, Chen X, Wang W, Zhang Y, Yang Z, Jin Y, et al. Glycyrrhizic acid as the antiviral component of Glycyrrhiza uralensis Fisch. against coxsackievirus A16 and enterovirus 71 of hand foot and mouth disease. J Ethnopharmacol. 2013;147:114-21 pubmed publisher
    The radices of Glycyrrhiza uralensis Fisch. and herbal preparations containing Glycyrrhiza spp...
  7. He J, Chen L, Heber D, Shi W, Lu Q. Antibacterial compounds from Glycyrrhiza uralensis. J Nat Prod. 2006;69:121-4 pubmed
    From the roots of Glycyrrhiza uralensis, two new pterocarpenes, glycyrrhizol A (1) and glycyrrhizol B (2), along with four known isoflavonoids, 5-O-methylglycryol (3), isoglycyrol (4), 6,8-diisoprenyl-5,7,4'-trihydroxyisoflavone (5), and ..
  8. Hwang C, Chun H. Isoliquiritigenin isolated from licorice Glycyrrhiza uralensis prevents 6-hydroxydopamine-induced apoptosis in dopaminergic neurons. Biosci Biotechnol Biochem. 2012;76:536-43 pubmed
    Licorice (Glycyrrhiza uralensis) is a medicinal herb containing various bioactive components implicated in antioxidative, anti-inflammatory, antiviral, and neuroprotective effects, but the effects of licorice against Parkinson's disease (..
  9. Ramilowski J, Sawai S, Seki H, Mochida K, Yoshida T, Sakurai T, et al. Glycyrrhiza uralensis transcriptome landscape and study of phytochemicals. Plant Cell Physiol. 2013;54:697-710 pubmed publisher
    Medicinal and industrial properties of phytochemicals (e.g. glycyrrhizin) from the root of Glycyrrhiza uralensis (licorice plant) made it an attractive, multimillion-dollar trade item...
  10. Zhao Z, Wang W, Guo H, Zhou D. Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats. Behav Brain Res. 2008;194:108-13 pubmed publisher
    ..The present study was designed to observe the effects of liquiritin, a flavone compound derived from Glycyrrhiza uralensis, on the behaviors of chronic variable stress induced depression model rats and to explore the possible ..
  11. Sun Z, Zhai M, Wang W, Li Y. [Effects of density on seedling growth and glycyrrhizinic acid content in Glycyrrhiza uralensis]. Zhongguo Zhong Yao Za Zhi. 2007;32:2222-6, 2281 pubmed
    To study the principle of interaction among individuals and populations in different Glycyrrhiza uralensis growth density.
  12. Seon M, Park S, Kwon S, Lim S, Choi H, Park H, et al. Hexane/ethanol extract of Glycyrrhiza uralensis and its active compound isoangustone A induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells. J Nutr Biochem. 2012;23:85-92 pubmed publisher
    ..We have previously demonstrated that the hexane/ethanol extract of Glycyrrhiza uralensis (HEGU) contains no detectable GL and suppresses doxorubicin-induced apoptosis in H9c2 rat cardiac ..
  13. Kim J, Park S, Yun K, Cho Y, Park H, Lee K. Isoliquiritigenin isolated from the roots of Glycyrrhiza uralensis inhibits LPS-induced iNOS and COX-2 expression via the attenuation of NF-kappaB in RAW 264.7 macrophages. Eur J Pharmacol. 2008;584:175-84 pubmed publisher
    In this study, the anti-inflammatory effects of flavonoids isolated from the roots of Glycyrrhiza uralensis (Leguminosae), namely, isoliquiritin (the glycoside of isoliquirigenin) and isoliquiritigenin (the aglycone of isoliquiritin) ..
  14. Kondo K, Shiba M, Nakamura R, Morota T, Shoyama Y. Constituent properties of licorices derived from Glycyrrhiza uralensis, G. glabra, or G. inflata identified by genetic information. Biol Pharm Bull. 2007;30:1271-7 pubmed
    Constituent properties of licorices derived from Glycyrrhiza uralensis, G. glabra, and G...
  15. Tang J, Song X, Zhu M, Zhang J. Study on the pharmacokinetics drug-drug interaction potential of Glycyrrhiza uralensis, a traditional Chinese medicine, with lidocaine in rats. Phytother Res. 2009;23:603-7 pubmed publisher
    Drug-drug interaction potentials of an herbal medicine named Glycyrrhiza uralensis was investigated in rats via in vitro and in vivo pharmacokinetic studies...
  16. Ahn J, Um M, Choi W, Kim S, Ha T. Protective effects of Glycyrrhiza uralensis Fisch. on the cognitive deficits caused by beta-amyloid peptide 25-35 in young mice. Biogerontology. 2006;7:239-47 pubmed
    ..This study was designed to determine the effects of Glycyrrhiza uralensis Fisch...
  17. Tao W, Duan J, Yang N, Tang Y, Liu M, Qian Y. Antithrombotic phenolic compounds from Glycyrrhiza uralensis. Fitoterapia. 2012;83:422-5 pubmed publisher
    ..and nine phenolic compounds were isolated from the ethyl acetate extract of the roots and rhizomes of Glycyrrhiza uralensis. Their structures were elucidated based on spectroscopic analysis and literature data, and anticoagulative ..
  18. Shin E, Zhou H, Guo L, Kim J, Lee S, Merfort I, et al. Anti-inflammatory effects of glycyrol isolated from Glycyrrhiza uralensis in LPS-stimulated RAW264.7 macrophages. Int Immunopharmacol. 2008;8:1524-32 pubmed publisher
    ..Taken together, our results indicate that glycyrol is an important anti-inflammatory constituent of Glycyrrhizae Radix, and that its anti-inflammatory effect is attributed to the inhibition I-kappaBalpha phosphorylation...
  19. Lee Y, Kim S, Jung S, Kim J, Pan C, Lim S. Aldose reductase inhibitory compounds from Glycyrrhiza uralensis. Biol Pharm Bull. 2010;33:917-21 pubmed
    We evaluated the inhibitory effects of components from the root of Glycyrrhiza uralensis (G...
  20. Li J, Tu Y, Tong L, Zhang W, Zheng J, Wei Q. Immunosuppressive activity on the murine immune responses of glycyrol from Glycyrrhiza uralensis via inhibition of calcineurin activity. Pharm Biol. 2010;48:1177-84 pubmed publisher
    ..Calcineurin (CN), a unique protein phosphatase, plays an important role in immune regulation. Our laboratory has established an effective molecular drug-screening model based on CN activity...
  21. Park S, Lim S, Kim J, Kang I, Kim J, Lee C, et al. Hexane-ethanol extract of Glycyrrhiza uralensis containing licoricidin inhibits the metastatic capacity of DU145 human prostate cancer cells. Br J Nutr. 2010;104:1272-82 pubmed publisher
    ..In the present study, we evaluated the effects of a hexane-ethanol extract of Glycyrrhiza uralensis (HEGU), which lacks glycyrrhizin, on the metastatic characteristics of DU145 prostate cancer cells...
  22. Kim J, Kim K, Lee Y, Cho C, Yoo H, Bang J, et al. Anti-angiogenic effects of water extract of a formula consisting of Pulsatilla koreana, Panax ginseng and Glycyrrhiza uralensis. Zhong Xi Yi Jie He Xue Bao. 2011;9:1005-13 pubmed
    This study aimed to investigate the anti-angiogenic effects of the water extract of Pulsatilla koreana (Yabe ex Nakai) Nakai ex T. Mori., Panax ginseng C.A. Meyer and Glycyrrhiza uralensis Fisch (WEPPG).
  23. Afreen F, Zobayed S, Kozai T. Melatonin in Glycyrrhiza uralensis: response of plant roots to spectral quality of light and UV-B radiation. J Pineal Res. 2006;41:108-15 pubmed
    ..Evidence for the occurrence of melatonin in the roots of Glycyrrhiza uralensis plants and the response of this plant to the spectral quality of light including red, blue and white light ..
  24. Kim H, Seo S, Lee B, Lee Y. Identification of tyrosinase inhibitors from Glycyrrhiza uralensis. Planta Med. 2005;71:785-7 pubmed
    Tyrosinase is a key enzyme in the production of melanins. Phytochemical studies of a Glycyrrhiza uralensis extract were performed by measuring the tyrosinase and melanin synthesis inhibitory activity...
  25. Kuo K, Chang J, Wang K, Chiang L. Water extract of Glycyrrhiza uralensis inhibited enterovirus 71 in a human foreskin fibroblast cell line. Am J Chin Med. 2009;37:383-94 pubmed
    ..Since EV71 infection commonly involves skin lesions, we tested our hypothesis that water extract of Glycyrrhiza uralensis (G...
  26. Ryu Y, Kim J, Park S, Chang J, Rho M, Bae K, et al. Inhibition of neuraminidase activity by polyphenol compounds isolated from the roots of Glycyrrhiza uralensis. Bioorg Med Chem Lett. 2010;20:971-4 pubmed publisher
    We isolated 18 polyphenols with neuraminidase inhibitory activity from methanol extracts of the roots of Glycyrrhiza uralensis. These polyphenols consisted of four chalcones (1-4), nine flavonoids (5-13), four coumarins (14-17), and one ..
  27. Seon M, Lim S, Choi H, Park S, Cho H, Kim J, et al. Isoangustone A present in hexane/ethanol extract of Glycyrrhiza uralensis induces apoptosis in DU145 human prostate cancer cells via the activation of DR4 and intrinsic apoptosis pathway. Mol Nutr Food Res. 2010;54:1329-39 pubmed publisher
    b>Glycyrrhiza uralensis (licorice) is one of the most frequently prescribed ingredients in Oriental medicine, and licorice extract has been shown to exert anti-carcinogenic effects...
  28. Wei G, Yang X, Zhang J, Gao J, Ma Y, Fu Y, et al. Rhizobialide: a new stearolactone produced by Mesorhizobium sp. CCNWGX022, a rhizobial endophyte from Glycyrrhiza uralensis. Chem Biodivers. 2007;4:893-8 pubmed
    The endophytic strain Mesorhizobium sp. CCNWGX022 was isolated from licorice (Glycyrrhiza uralensis Fisch.) grown in the arid and semi-arid regions of Northwest China...
  29. Kwon H, Kim H, Ryu Y, Kim J, Jeong H, Lee S, et al. In vitro anti-rotavirus activity of polyphenol compounds isolated from the roots of Glycyrrhiza uralensis. Bioorg Med Chem. 2010;18:7668-74 pubmed publisher
    We evaluated the ability of six polyphenols isolated from the roots of Glycyrrhiza uralensis to inactivate rotaviruses, specially G5P[7] and G8P[7]...
  30. Liu P, Ge Y, Ma T, Ren H, Xu Y, Xu D. [Effects of the extracts from decoction for resuscitation and its component herbs on PGI2, TXA2 and NO release from rat vascular endothelial cells under hypoxia in vitro]. Zhongguo Zhong Yao Za Zhi. 2004;29:988-92 pubmed
    ..The effect of DRE on the parameters in culture medium of rat vascular endothelial cells under hypoxia was better than that of the extracts from its component herbs. ..
  31. Li Y, Luo H, Sun C, Song J, Sun Y, Wu Q, et al. EST analysis reveals putative genes involved in glycyrrhizin biosynthesis. BMC Genomics. 2010;11:268 pubmed publisher
    b>Glycyrrhiza uralensis is one of the most popular medicinal plants in the world and is also widely used in the flavoring of food and tobacco...
  32. Wang J, Liu C, Wang W. [The investigation of the licorice resources in northeast China]. Zhongguo Zhong Yao Za Zhi. 2003;28:308-12 pubmed
    To find out the licorice(Glycyrrhiza uralensis) distribution area, resource complexion and resource reserves of northeast China, to analyze the cause of the swing of the pendulum of resources, to put forward the countermeasure of ..
  33. Li Z, Han J, Li C, Cai W, Cen Q. [Study of hydroscopicity of Glycyrrhiza uralensis Fisch]. Zhong Yao Cai. 2007;30:223-5 pubmed
    To study hydroscopicity of Glycyrrhiza uralensis Fisch and screen the best compounding of adjuvant, and measure critical relative humidity of the best anagraph for providing reasonable relative humidity of production...
  34. Zhao R, Zhao L, Zhou Y, Li D, Hao W, Chen K. [Experimental study of Bailian Caogen granule on pharmacodynamics]. Zhongguo Zhong Yao Za Zhi. 2006;31:672-5 pubmed
    ..To study the analgesic, antipyretic and anti-inflammatory effect of Bailian Caogen granule...
  35. Yang N, Patil S, Zhuge J, Wen M, Bolleddula J, Doddaga S, et al. Glycyrrhiza uralensis flavonoids present in anti-asthma formula, ASHMI™, inhibit memory Th2 responses in vitro and in vivo. Phytother Res. 2013;27:1381-91 pubmed publisher
    Allergic asthma is associated with Th2-mediated inflammation. Several flavonoids were isolated from Glycyrrhiza uralensis, one of the herbs in the anti-asthma herbal medicine intervention...
  36. Park S, Kwon S, Lim S, Kim J, Lee K, Park J. Licoricidin, an Active Compound in the Hexane/Ethanol Extract of Glycyrrhiza uralensis, Inhibits Lung Metastasis of 4T1 Murine Mammary Carcinoma Cells. Int J Mol Sci. 2016;17: pubmed publisher
    ..Because glycyrrhizin induces severe hypokalemia and hypertension, we prepared a hexane/ethanol extract of Glycyrrhiza uralensis (HEGU) that lacks glycyrrhizin, and showed that HEGU induces apoptosis and G1 cell cycle arrest and ..
  37. Egamberdieva D, Wirth S, Li L, Abd Allah E, Lindström K. Microbial cooperation in the rhizosphere improves liquorice growth under salt stress. Bioengineered. 2017;8:433-438 pubmed publisher
    Liquorice (Glycyrrhiza uralensis Fisch.) is one of the most widely used plants in food production, and it can also be used as an herbal medicine or for reclamation of salt-affected soils...
  38. Gafner S, Bergeron C, Villinski J, Godejohann M, Kessler P, Cardellina J, et al. Isoflavonoids and coumarins from Glycyrrhiza uralensis: antibacterial activity against oral pathogens and conversion of isoflavans into isoflavan-quinones during purification. J Nat Prod. 2011;74:2514-9 pubmed publisher
    Phytochemical investigation of a supercritical fluid extract of Glycyrrhiza uralensis has led to the isolation of 20 known isoflavonoids and coumarins, and glycycarpan (7), a new pterocarpan...
  39. López Baena F, Ruiz Sainz J, Rodríguez Carvajal M, Vinardell J. Bacterial Molecular Signals in the Sinorhizobium fredii-Soybean Symbiosis. Int J Mol Sci. 2016;17: pubmed publisher
    ..nodules, such as the important crops soybean and cowpea, and plants forming indeterminate nodules, such as Glycyrrhiza uralensis and pigeon-pea...
  40. Singh A, Zhao K. Treatment of Insomnia With Traditional Chinese Herbal Medicine. Int Rev Neurobiol. 2017;135:97-115 pubmed publisher
    ..in Chinese herbal medicine including Suanzaoren (Ziziphus spinose ), Fuling (Poria cocos ), and Gancao (Glycyrrhiza uralensis )...
  41. Feng W, Wang W, Zhao P. [Content variation of saponins and flavonoids from growing and harvesting time of Glycyrrhiza uralensis]. Zhong Yao Cai. 2008;31:184-6 pubmed
    ..uralensis Fisch to know theObjective: Determining and comparing the saponins and flavonoids contents in Glycyrrhiza uralensis Fisch to know the dynamic variation. The contents were determined by ultraviolet spectrophotometry...
  42. Wang Y, Liu Z, Song F, Liu S. [Study on the combination principles about aconite roots by electrospray ionization mass spectrometry]. Yao Xue Xue Bao. 2003;38:451-4 pubmed
    ..Acidity is a key factor to influence the hydrolysis of diester-diterpenoid alkaloids, and the hydrolysis of alkaloids are inhibited in high acidity, which lead to the high toxicity of the decoction containing aconite roots. ..
  43. Liu X, Chen H, Li J, Zhang R, Turlings T, Chen L. Volatiles released by Chinese liquorice roots mediate host location behaviour by neonate Porphyrophora sophorae (Hemiptera: Margarodidae). Pest Manag Sci. 2016;72:1959-64 pubmed publisher
    ..Hemiptera: Coccoidea, Margarodidae), is one of the most serious arthropod pests of Chinese liquorice, Glycyrrhiza uralensis (Fabaceae), an important medicinal herb...
  44. Qiu C, Zhang T, Zhang W, Zhou L, Yu B, Wang W, et al. Licochalcone A Inhibits the Proliferation of Human Lung Cancer Cell Lines A549 and H460 by Inducing G2/M Cell Cycle Arrest and ER Stress. Int J Mol Sci. 2017;18: pubmed publisher
    Licochalcone A (LicA), a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch, has wide spectrum of pharmacological activities...
  45. Wu L, Fan Y, Fan C, Yu Y, Sun L, Jin Y, et al. Licocoumarone isolated from Glycyrrhiza uralensis selectively alters LPS-induced inflammatory responses in RAW 264.7 macrophages. Eur J Pharmacol. 2017;801:46-53 pubmed publisher
    The effects of licocoumarone (LC) isolated from Glycyrrhiza uralensis were studied in LPS-stimulated RAW 264.7 macrophages...
  46. Rong Q, Xu Q, Liu C, Huang L. [Cloning and characterization of 3-hydroxy-3-methylglutary CoA reductase cDNA of Glycyrrhiza uralensis]. Zhongguo Zhong Yao Za Zhi. 2011;36:1275-9 pubmed
    To clone and analysis the sequence of 3-hydroxy-3-methylglutary CoA reductase (HMGR) cDNA from Glycyrrhiza uralensis. The primers were designed based on the conservative region of HMGR nucleic acids sequence from public database...
  47. Fukai T, Oku Y, Hano Y, Terada S. Antimicrobial activities of hydrophobic 2-arylbenzofurans and an isoflavone against vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus. Planta Med. 2004;70:685-7 pubmed
    ..13-6.25 microg/mL). Five compounds also showed antibacterial activity against ten MRSA strains (MIC80 = 3.13 microg/mL). ..
  48. Zhang L, Xu D, Feng Y. [Study on adscription of plasma effective constituents of rat after administrated with Paeonia lacliflora and Glycyrrhiza uralensis compound]. Zhongguo Zhong Yao Za Zhi. 2007;32:1789-91 pubmed
    ..adscription of plasma effective constituents of rat after oral administration of Paeonia lacliflora and Glycyrrhiza uralensis compound...
  49. Lin T, Yeh M, Cheng Y, Lin L, Sung J. Using ITS2 PCR-RFLP to generate molecular markers for authentication of Sophora flavescens Ait. J Sci Food Agric. 2012;92:892-8 pubmed
    ..flavescens Ait. The technique is also suitable for analysing S. flavescens Ait. mixed with other adulterants. ..
  50. Lee S, Lee H, Shin Y, Kang H, Cho H. The anti-HSV-1 effect of quercetin is dependent on the suppression of TLR-3 in Raw 264.7 cells. Arch Pharm Res. 2017;40:623-630 pubmed publisher
    Quercetin is a major component of the plant Glycyrrhiza uralensis, which is largely used as a traditional medicine in Asia...
  51. Wang D, Wan C, Wang W, Gu B, Li J, Wang W, et al. [Effect of Tongfeng trace elements nutrient balance agent on growth, physiological characteristics and content of active constituents of Glycyrrhiza uralensis]. Zhongguo Zhong Yao Za Zhi. 2011;36:2027-31 pubmed
    ..indicators, physiological indicators, and the contents of liquiritin and glycyrrhizic acid in one-year old Glycyrrhiza uralensis. The plants of G...
  52. Alfajaro M, Kim H, Park J, Ryu E, Kim J, Jeong Y, et al. Anti-rotaviral effects of Glycyrrhiza uralensis extract in piglets with rotavirus diarrhea. Virol J. 2012;9:310 pubmed publisher
    ..has exerted antiviral properties against several viruses. In this study, anti-rotaviral efficacy of Glycyrrhiza uralensis extract (GUE) as an effective and cheaper remedy without side-effects was evaluated in colostrums-deprived ..
  53. Wang Y, Wang Y, Yan H. [The research of the adsorption and desorption behaveior of macroporous resin for glycyrrhizic acid]. Zhongguo Zhong Yao Za Zhi. 2006;31:295-7 pubmed
    ..To investigate the performance of static and dynamic adsorption and desorption of the three macroporous resins of AB-8, D-101 and H-103...
  54. Chu M, Liu G. [Kinetic model for extraction process of Chinese traditional medicine]. Yao Xue Xue Bao. 2002;37:559-62 pubmed
    ..To present a theory bases for Chinese traditional medicine extraction process...
  55. Wang P, Zhong Z, Zhou J, Cai T, Zhu J. Exopolysaccharide biosynthesis is important for Mesorhizobium tianshanense: plant host interaction. Arch Microbiol. 2008;189:525-30 pubmed publisher
    Mesorhizobium tianshanense is a nitrogen-fixing bacterium that can establish symbiotic associations with Glycyrrhiza uralensis in the form of root nodules. Nodule formation in rhizobia often requires various secreted carbohydrates...
  56. Zhang H, Dong Y, Hu S, Ren S. [The comparison about inhibition of five Chinese herbal medicines to two different resources alpha-glycosidase]. Zhong Yao Cai. 2008;31:1024-7 pubmed
    ..To compare alpha-glycosidase inhibitor microamount screening models which are established by two different resources alpha-glycosidase to screen the Chinese herbal medicines which have great alpha-glycosidase inhibition...
  57. Cao H, Yang M, Zheng H, Zhang J, Zhong Z, Zhu J. Complex quorum-sensing regulatory systems regulate bacterial growth and symbiotic nodulation in Mesorhizobium tianshanense. Arch Microbiol. 2009;191:283-9 pubmed publisher
    ..deficient mutants showed a reduced growth rate and were defective in nodule formation on their host plant Glycyrrhiza uralensis. These data suggest that different M...
  58. Dai Y, Li Z, Xue L, Dou C, Zhou Y, Zhang L, et al. Metabolomics study on the anti-depression effect of xiaoyaosan on rat model of chronic unpredictable mild stress. J Ethnopharmacol. 2010;128:482-9 pubmed publisher
    ..Wolf), Radix Paeoniae Alba (Paeonia lactiflora Pall.), Radix Glycyrrhizae (Glycyrrhiza uralensis Fisch.), Radix Bupleuri (Bupleurum chinense DC.), Radix Angelicae Sinensis (Angelica sinensis (Oliv...
  59. Zheng Y, Yang J, Wei J, Huang L, Peng G. [Multi-index determination and optimization of liquirtin separated from polyamide resin]. Zhongguo Zhong Yao Za Zhi. 2013;38:3902-6 pubmed
    ..86% to 88.5%. The method was simple and feasible, it could obtain a higher purity in extracts from liquirtin and provide basis for industrialized separation and preparation of liquirtin...
  60. Fukuda E, Uesawa Y, Baba M, Okada Y. Application of mixture analysis to crude materials from natural resources (IV)[1(a-c)]: identification of Glycyrrhiza species by direct analysis in real time mass spectrometry (II). Nat Prod Commun. 2013;8:1721-4 pubmed
    In order to identify Glycyrrhiza species by chemical fingerprinting, the bark of the roots and stolons of Glycyrrhiza uralensis Fischer and G. glabra Linné were analyzed using DART (Direct Analysis in Real Time)-MS...
  61. Liu Y, Xu Q, Wang X, Liu C, Chen H. [Researches on the influence of 3-hydroxy-3-methylglutary-coenzyme A reductase gene polymorphism on catalytic efficiency of its encode enzyme in Glycyrrhiza uralensis]. Zhongguo Zhong Yao Za Zhi. 2012;37:3784-8 pubmed
    ..genic mutation on the conversion efficiency of MVA with GC-MS method, in order to lay a foundation for revealing the function of HMGR gene polymorphism of Glycyrrhiza uralensis in the production of high-quality G. uralensis medicines.
  62. Keyler D, Baker J, Lee D, Overstreet D, Boucher T, Lenz S. Toxicity study of an antidipsotropic Chinese herbal mixture in rats: NPI-028. J Altern Complement Med. 2002;8:175-83 pubmed
    ..To determine the potential toxicity and safety of the Chinese herbal medicine NPI-028 in rats following subchronic (3-month) exposure via daily oral consumption...
  63. Xin X, Liu Y, Ye M, Guo H, Guo D. Microbial transformation of glycyrrhetinic acid by Mucor polymorphosporus. Planta Med. 2006;72:156-61 pubmed
    ..Glycyrrhetinic acid (GA; 1) is one of the major constituents of a traditional Chinese medicine, the roots of Glycyrrhiza uralensis, called Gancao in Chinese...
  64. Chen Y, Qian D, Shang E, Qian Y, Liu P, Su S, et al. [The incompatibility mechanism based on the interaction of multiple-components for Flos Genkwa and Radix et Rhizoma Glycyrrhizae]. Yao Xue Xue Bao. 2012;47:1043-8 pubmed
  65. Wang W, Shi X, Zhai L, Wang P, Peng X, Xu Y. [Influence of compatibility on content of berberine in Maxingganshi decoction]. Zhong Yao Cai. 2007;30:602-5 pubmed
    ..To set up the quantitative method of herberine in decoctions prepared from various combinations of Maxingganshi decotion by HPLC and to determine the change of general contents in different decoction...
  66. Hayashi H, Inoue K, Ozaki K, Watanabe H. Comparative analysis of ten strains of Glycyrrhiza uralensis cultivated in Japan. Biol Pharm Bull. 2005;28:1113-6 pubmed
    Comparative analysis of 10 strains of Glycyrrhiza uralensis cultivated in Kyoto, Japan, was undertaken to characterize their variations...
  67. Wu Z, Luo J, Tan X. [Research on the influence of compatibility on fingerprint of Glycyrrhiza uralensis in mahuang decoctions by HPLC]. Zhongguo Zhong Yao Za Zhi. 2006;31:209-12 pubmed
    To set up the HPLC fingerprint of Glycyrrhiza uralensis in decoctions prepared from various combinations of the recipe named Mahuang decoctions and study the influence of compatibility on fingerprint of G. wralensis in decoctions.
  68. Liu K, Wu W, He W, Sun H. [Study on sini decoction in treatment of intestinal ischemia-reperfusion injury in rats: mechanism relating to oxygen radical and bcl-2 protein]. Zhongguo Zhong Yao Za Zhi. 2006;31:329-32, 348 pubmed
    ..To investigate the protective effect of Sini decoction (SND) on intestinal mucosa in rats with intestinal ischemia reperfusion (I/R) and the mechanism relating to oxygen radical and Bcl-2 protein expression...
  69. Rong Q, Liu C, Duan T. [Content deternmination of glycyrrhizic acid in cortex glycyrrhizae]. Zhong Yao Cai. 2006;29:891-2 pubmed
    ..Furtheronore, Fen Gancao should be further studied in order to reveal the differences of pharmacological effects between Fen Gancao and Licorice Root (Radix Glycyrrhizae)...
  70. Yang Q, Zhang H, Wang W, Liu C, Wei S. [Construction and analysis of root cDNA library in Glycyrrhiza uralensis]. Zhongguo Zhong Yao Za Zhi. 2008;33:1386-9 pubmed
    To screen and isolate secondary metabolite biosynthesis-related gene for establishing the foundation of functional gene research, we construct a cDNA library of Glycyrrhiza uralensis.
  71. Shen Z, Liu C, Wang X, Guo W, Li B. [Correlation analysis between single nucleotide polymorphism of beta-amyrin synthase and content of glycyrrhizic acid in Glycyrrhiza uralensis]. Zhongguo Zhong Yao Za Zhi. 2010;35:813-6 pubmed
    To analyze the correlation between content of glycyrrhizic acid and the single nucleotide polymorphism of beta-amyrin synthase (bAS) in Glycyrrhiza uralensis.
  72. Luo L, Shen L, Sun F, Ma Z. Immunoprecipitation coupled with HPLC-MS/MS to discover the aromatase ligands from Glycyrrhiza uralensis. Food Chem. 2013;138:315-20 pubmed publisher
    ..immunoprecipitation (IP) coupled with HPLC-DAD-MS was developed to discover the aromatase ligands from Glycyrrhiza uralensis. An SB-C18 column was employed to separate target compounds without special consideration in mobile phase...
  73. Armanini D, Nacamulli D, Francini Pesenti F, Battagin G, Ragazzi E, Fiore C. Glycyrrhetinic acid, the active principle of licorice, can reduce the thickness of subcutaneous thigh fat through topical application. Steroids. 2005;70:538-42 pubmed
  74. Liu Y, Liu C. [Study on the spatial and temporal expression of beta-AS gene of Glycyrriza uralensis]. Zhong Yao Cai. 2012;35:528-31 pubmed
    ..To reveal the temporal and spatial specificity of the expression of beta-AS gene of Glycyrriza uralensis...
  75. Wei S, Wang W, Wang J, Sun Z, Liu C, Wang H, et al. [Preliminary study in glycyrrhizin content and its influencing factors of wild and cultivated in different region of China]. Zhongguo Zhong Yao Za Zhi. 2012;37:1341-5 pubmed
    In order to understand the glycyrrhizin content range in the wild and cultivated Glycyrrhiza uralensis in China and to find the related influencing factors of glycyrrhizin content.
  76. Cheng A, Wan F, Jin Z, Wang J, Xu X. Nitrite oxide and inducible nitric oxide synthase were regulated by polysaccharides isolated from Glycyrrhiza uralensis Fisch. J Ethnopharmacol. 2008;118:59-64 pubmed publisher
    Water-soluble polysaccharide(Glycyrrhiza polysaccharide, GP) was isolated from Glycyrrhiza uralensis Fisch, with glycosidic units were composed of alpha (1-4) linked D-glucana...