glycyrrhiza

Summary

Summary: A genus of leguminous herbs or shrubs whose roots yield GLYCYRRHETINIC ACID and its derivative, CARBENOXOLONE.

Top Publications

  1. Fiore C, Eisenhut M, Krausse R, Ragazzi E, Pellati D, Armanini D, et al. Antiviral effects of Glycyrrhiza species. Phytother Res. 2008;22:141-8 pubmed
    Historical sources for the use of Glycyrrhiza species include ancient manuscripts from China, India and Greece. They all mention its use for symptoms of viral respiratory tract infections and hepatitis...
  2. Kalani K, Kushwaha V, Verma R, Murthy P, Srivastava S. Glycyrrhetinic acid and its analogs: a new class of antifilarial agents. Bioorg Med Chem Lett. 2013;23:2566-70 pubmed publisher
    Although a number of chemicals have been isolated from Glycyrrhiza glabra, only a few have been evaluated for their biological significance...
  3. Arino A, Herrera M, Langa E, Raso J, Herrera A. Ochratoxin A in liquorice as affected by processing methods. Food Addit Contam. 2007;24:987-92 pubmed
    ..1% reduction). A great reduction in the OTA level was found during the production of liquorice extract (78.6%) and block liquorice (91.8%). ..
  4. Chandrasekaran C, Sundarajan K, Gupta A, Srikanth H, Edwin J, Agarwal A. Evaluation of the genotoxic potential of standardized extract of Glycyrrhiza glabra (GutGard™). Regul Toxicol Pharmacol. 2011;61:373-80 pubmed publisher
    b>Glycyrrhiza glabra Linn. (licorice) is widespread throughout the Mediterranean region and certain areas of Asia...
  5. Cui Y, Ao M, Li W, Yu L. Effect of glabridin from Glycyrrhiza glabra on learning and memory in mice. Planta Med. 2008;74:377-80 pubmed publisher
    Glabridin was isolated from the roots of Glycyrrhiza glabra and its effects on cognitive functions and cholinesterase activity were investigated in mice. Glabridin (1, 2 and 4 mg kg (-1), P. O.) and piracetam (400 mg kg (-1), i. p...
  6. Franceschelli S, Pesce M, Vinciguerra I, Ferrone A, Riccioni G, Patruno A, et al. Licocalchone-C extracted from Glycyrrhiza glabra inhibits lipopolysaccharide-interferon-? inflammation by improving antioxidant conditions and regulating inducible nitric oxide synthase expression. Molecules. 2011;16:5720-34 pubmed publisher
    The genus Glycyrrhiza consists of about 30 species, amoung these, G...
  7. Boganen H, van Hee K, Grundmeijer H. [Hypertension due to liquorice and liquorice tea consumption]. Ned Tijdschr Geneeskd. 2007;151:2825-8 pubmed
    ..5 mg a day. This means no more than 10-30 g liquorice and no more than half a cup of liquorice tea a day. --On diagnosing hypertension, the effects of liquorice and liquorice tea consumption on blood pressure should be kept in mind...
  8. Yang Y, He F, Yu L, Chen X, Lei J, Ji J. Influence of drought on oxidative stress and flavonoid production in cell suspension culture of Glycyrrhiza inflata Batal. Z Naturforsch C. 2007;62:410-6 pubmed
    ..and physiological parameters characteristic for oxidative stress were studied in a cell suspension culture of Glycyrrhiza inflata Batal to investigate its drought tolerance...
  9. Yoon G, Lee W, Kim S, Cheon S. Inhibitory effect of chalcones and their derivatives from Glycyrrhiza inflata on protein tyrosine phosphatase 1B. Bioorg Med Chem Lett. 2009;19:5155-7 pubmed publisher
    Compounds (1-6) isolated from the CH(2)Cl(2) extract of Glycyrrhiza inflata and semisynthetic licochalcone A derivatives (7-14) were evaluated for their protein tyrosine phosphatase 1B (PTP1B) inhibitory activities...

More Information

Publications66

  1. Simons R, Vincken J, Bakx E, Verbruggen M, Gruppen H. A rapid screening method for prenylated flavonoids with ultra-high-performance liquid chromatography/electrospray ionisation mass spectrometry in licorice root extracts. Rapid Commun Mass Spectrom. 2009;23:3083-93 pubmed publisher
    ..ethanol, ethanol and ethyl acetate extract of the roots of Glycyrrhiza glabra indicated the presence of 70 mono- and di-prenylated flavonoids...
  2. Siracusa L, Saija A, Cristani M, Cimino F, D Arrigo M, Trombetta D, et al. Phytocomplexes from liquorice (Glycyrrhiza glabra L.) leaves--chemical characterization and evaluation of their antioxidant, anti-genotoxic and anti-inflammatory activity. Fitoterapia. 2011;82:546-56 pubmed publisher
    Three extracts of different polarities of Glycyrrhiza glabra L. leaves were characterized and evaluated for their antioxidant, anti-genotoxic and anti-inflammatory activity...
  3. Ito C, Oi N, Hashimoto T, Nakabayashi H, Aoki F, Tominaga Y, et al. Absorption of dietary licorice isoflavan glabridin to blood circulation in rats. J Nutr Sci Vitaminol (Tokyo). 2007;53:358-65 pubmed
    ..Thus, dietary glabridin was at least partly incorporated into the body in an unchanged form, though most dietary flavonoids are converted to non-active conjugate forms during intestinal absorption...
  4. Wu Y, Meng X, Bao Y, Wang S, Kang T. Simultaneous quantitative determination of nine active chemical compositions in traditional Chinese medicine Glycyrrhiza by RP-HPLC with full-time five-wavelength fusion method. Am J Chin Med. 2013;41:211-9 pubmed publisher
    ..calycosin, isoliquiritigenin, Glycyrrhizic acid monoammonium salt) in traditional Chinese medicine Glycyrrhiza was developed using reverse phase high-performance liquid chromatography (RP-HPLC) coupled with a diode-array ..
  5. Yoon G, Kang B, Cheon S. Topoisomerase I inhibition and cytotoxicity of licochalcones A and E from Glycyrrhiza inflata. Arch Pharm Res. 2007;30:313-6 pubmed
    Licochalcones A (1) and E (2), retrochalcones or reversely constructed chalcones, isolated from the roots of Glycyrrhiza inflata, were evaluated for their cytotoxicities against four different human tumor cell lines; A549 (lung), SK-OV-3 ..
  6. Choi Y, Lim S, Jung J, Choi J, Kim J, Han S, et al. Blockade of nitroxidative stress by roasted licorice extracts in high glucose-exposed endothelial cells. J Cardiovasc Pharmacol. 2008;52:344-54 pubmed publisher
    ..5 mM and 33 mM glucose for 5 d in the absence and presence of 1 to 20 mug/mL roasted licorice (Glycyrrhiza inflata Bat.) ethanol extracts (rLE)...
  7. Thiyagarajan P, Chandrasekaran C, Deepak H, Agarwal A. Modulation of lipopolysaccharide-induced pro-inflammatory mediators by an extract of Glycyrrhiza glabra and its phytoconstituents. Inflammopharmacology. 2011;19:235-41 pubmed publisher
    To evaluate the inhibitory property of de-glycyrrhizinated extract of Glycyrrhiza glabra root and its phytoconstituents (glabridin, isoliquiritigenin and glycyrrhizin) on LPS-induced production of pro-inflammatory mediators.
  8. Nakagawa K, Kitano M, Kishida H, Hidaka T, Nabae K, Kawabe M, et al. 90-Day repeated-dose toxicity study of licorice flavonoid oil (LFO) in rats. Food Chem Toxicol. 2008;46:2349-57 pubmed publisher
    ..Based on these findings, it is concluded that the no-observed-adverse-effect level (NOAEL) for the LFO concentrate solution is estimated to be 800 mg/kg/day for female rats, and approximately 400 mg/kg/day for male rats...
  9. Dong S, Inoue A, Zhu Y, Tanji M, Kiyama R. Activation of rapid signaling pathways and the subsequent transcriptional regulation for the proliferation of breast cancer MCF-7 cells by the treatment with an extract of Glycyrrhiza glabra root. Food Chem Toxicol. 2007;45:2470-8 pubmed
    b>Glycyrrhiza glabra root is one of the common traditional Chinese medicines and used as flavoring and sweetening agents for tobaccos, chewing gums, candies, toothpaste and beverages...
  10. Liu H, Wang J, Zhou W, Wang Y, Yang L. Systems approaches and polypharmacology for drug discovery from herbal medicines: an example using licorice. J Ethnopharmacol. 2013;146:773-93 pubmed publisher
    ..Licorice was used as an example to show drug discovery from herbal drugs using systems approaches and polypharmacology...
  11. Kuroda M, Mimaki Y, Honda S, Tanaka H, Yokota S, Mae T. Phenolics from Glycyrrhiza glabra roots and their PPAR-gamma ligand-binding activity. Bioorg Med Chem. 2010;18:962-70 pubmed publisher
    Bioassay-guided fractionation of the EtOH extract of licorice (Glycyrrhiza glabra roots), using a GAL-4-PPAR-gamma chimera assay method, resulted in the isolation of 39 phenolics, including 10 new compounds (1-10)...
  12. Carmeli E, Harpaz Y, Kogan N, Fogelman Y. The effect of an endogenous antioxidant glabridin on oxidized LDL. J Basic Clin Physiol Pharmacol. 2008;19:49-63 pubmed
    ..We conclude that the dietary consumption of glabridin can partially protect LDL from oxidation...
  13. Aoki F, Honda S, Kishida H, Kitano M, Arai N, Tanaka H, et al. Suppression by licorice flavonoids of abdominal fat accumulation and body weight gain in high-fat diet-induced obese C57BL/6J mice. Biosci Biotechnol Biochem. 2007;71:206-14 pubmed
    ..These findings suggest that LFO prevented and ameliorated diet-induced obesity via the regulation of lipid metabolism-related gene expression in the liver...
  14. Asl M, Hosseinzadeh H. Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds. Phytother Res. 2008;22:709-24 pubmed publisher
    The roots and rhizomes of licorice (Glycyrrhiza) species have long been used worldwide as a herbal medicine and natural sweetener...
  15. Ju Y, Doerge D, Helferich W. A dietary supplement for female sexual dysfunction, Avlimil, stimulates the growth of estrogen-dependent breast tumors (MCF-7) implanted in ovariectomized athymic nude mice. Food Chem Toxicol. 2008;46:310-20 pubmed
  16. Zhu Z, Li C, Wang X, Yang Z, Chen J, Hu L, et al. 2,2',4'-trihydroxychalcone from Glycyrrhiza glabra as a new specific BACE1 inhibitor efficiently ameliorates memory impairment in mice. J Neurochem. 2010;114:374-85 pubmed publisher
    ..Here, we reported that the natural product 2,2',4'-trihydroxychalcone (TDC) from Glycyrrhiza glabra functioned as a specific non-competitive inhibitor against BACE1 enzyme, and potently repressed beta-..
  17. Nakagawa K, Hidaka T, Kitano M, Asakura M, Kamigaito T, Noguchi T, et al. Genotoxicity studies on licorice flavonoid oil (LFO). Food Chem Toxicol. 2008;46:2525-32 pubmed publisher
    ..From the findings obtained from the genotoxicity assays performed in this study and the published pharmacokinetic studies of LFO, it appears unlikely that dietary consumption of LFO will present any genotoxic hazard to humans...
  18. Kondo K, Shiba M, Nakamura R, Morota T, Shoyama Y. Constituent properties of licorices derived from Glycyrrhiza uralensis, G. glabra, or G. inflata identified by genetic information. Biol Pharm Bull. 2007;30:1271-7 pubmed
    Constituent properties of licorices derived from Glycyrrhiza uralensis, G. glabra, and G...
  19. Kamisoyama H, Honda K, Tominaga Y, Yokota S, Hasegawa S. Investigation of the anti-obesity action of licorice flavonoid oil in diet-induced obese rats. Biosci Biotechnol Biochem. 2008;72:3225-31 pubmed
    Licorice flavonoid oil (LFO), which contains hydrophobic flavonoids from Glycyrrhiza glabra LINNE, is a new ingredient for functional foods. In this study, we investigated the anti-obesity action of LFO in diet-induced obese rats...
  20. Fatima A, Gupta V, Luqman S, Negi A, Kumar J, Shanker K, et al. Antifungal activity of Glycyrrhiza glabra extracts and its active constituent glabridin. Phytother Res. 2009;23:1190-3 pubmed publisher
    Glabridin, an active constituent of Glycyrrhiza glabra roots, was found to be active against both yeast and filamentous fungi...
  21. Montoro P, Maldini M, Russo M, Postorino S, Piacente S, Pizza C. Metabolic profiling of roots of liquorice (Glycyrrhiza glabra) from different geographical areas by ESI/MS/MS and determination of major metabolites by LC-ESI/MS and LC-ESI/MS/MS. J Pharm Biomed Anal. 2011;54:535-44 pubmed publisher
    ..to the full characterization of saponins and phenolics in hydroalcoholic extracts of roots of liquorice (Glycyrrhiza glabra)...
  22. Chang Y, Chen C, Kuo C, Chen B, You J. Glycyrrhetinic acid inhibits ICAM-1 expression via blocking JNK and NF-kappaB pathways in TNF-alpha-activated endothelial cells. Acta Pharmacol Sin. 2010;31:546-53 pubmed publisher
  23. Gupta V, Fatima A, Faridi U, Negi A, Shanker K, Kumar J, et al. Antimicrobial potential of Glycyrrhiza glabra roots. J Ethnopharmacol. 2008;116:377-80 pubmed publisher
    The present study was aimed to investigate antimicrobial potential of Glycyrrhiza glabra roots. Antimycobacterial activity of Glycyrrhiza glabra was found at 500 microg/mL concentration...
  24. Furusawa J, Funakoshi Tago M, Mashino T, Tago K, Inoue H, Sonoda Y, et al. Glycyrrhiza inflata-derived chalcones, Licochalcone A, Licochalcone B and Licochalcone D, inhibit phosphorylation of NF-kappaB p65 in LPS signaling pathway. Int Immunopharmacol. 2009;9:499-507 pubmed
    ..Licochalcone A is a major component of Xinjiang licorice, Glycyrrhiza inflata...
  25. Birari R, Gupta S, Mohan C, Bhutani K. Antiobesity and lipid lowering effects of Glycyrrhiza chalcones: experimental and computational studies. Phytomedicine. 2011;18:795-801 pubmed publisher
    Twelve flavonoids (1-12), isolated from Glycyrrhiza glabra roots were evaluated for their pancreatic lipase (PL) inhibitory activity in vitro. The structures of the isolated compounds were elucidated by spectroscopic methods...
  26. Li Y, Li S, Dong Y, Zhang Y, Fu C, Yu L. Stable transformation of suspension-cultured Glycyrrhiza inflata batalin cells with Agrobacterium tumefaciens. Z Naturforsch C. 2012;67:603-10 pubmed
    A protocol for the efficient genetic transformation of licorice (Glycyrrhiza inflata Batalin) cells in suspension culture using Agrobacterium tumefaciens-mediated T-DNA delivery is described. G...
  27. Herrera M, Herrera A, Arino A. Estimation of dietary intake of ochratoxin A from liquorice confectionery. Food Chem Toxicol. 2009;47:2002-6 pubmed publisher
    ..Risk assessment in a worst case scenario (children high consumers and maximum content of OTA) represented 8.94% TWI by liquorice confectionery alone...
  28. Mersereau J, Levy N, Staub R, Baggett S, Zogovic T, Zogric T, et al. Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist. Mol Cell Endocrinol. 2008;283:49-57 pubmed publisher
    ..In a mouse xenograph model, liquiritigenin did not stimulate uterine size or tumorigenesis of MCF-7 breast cancer cells. Our results demonstrate that some plants contain highly selective estrogens for ERbeta...
  29. Kawakami Z, Ikarashi Y, Kase Y. Glycyrrhizin and its metabolite 18 beta-glycyrrhetinic acid in glycyrrhiza, a constituent herb of yokukansan, ameliorate thiamine deficiency-induced dysfunction of glutamate transport in cultured rat cortical astrocytes. Eur J Pharmacol. 2010;626:154-8 pubmed publisher
    ..Among the seven constituent herbs of yokukansan, significant effects were found for glycyrrhiza. Furthermore, glycyrrhizin and its metabolite 18 beta-glycyrrhetinic acid (10(-7)-10(-4)M), among the eight ..
  30. Kalani K, Agarwal J, Alam S, Khan F, Pal A, SRIVASTAVA S. In silico and in vivo anti-malarial studies of 18? glycyrrhetinic acid from Glycyrrhiza glabra. PLoS ONE. 2013;8:e74761 pubmed publisher
    ..5-250 mg/kg on day 8. To the best of our knowledge this is the first ever report on the anti-malarial potential of GA. Further work on optimization of the anti-malarial lead is under progress...
  31. Shin Y, Bae E, Lee B, Lee S, Kim J, Kim Y, et al. In vitro and in vivo antiallergic effects of Glycyrrhiza glabra and its components. Planta Med. 2007;73:257-61 pubmed
    Licorice (Glycyrrhiza glabra L., Leguminosae) is frequently used in traditional medicine to treat inflammatory and allergic diseases...
  32. Honda K, Kamisoyama H, Tominaga Y, Yokota S, Hasegawa S. The molecular mechanism underlying the reduction in abdominal fat accumulation by licorice flavonoid oil in high fat diet-induced obese rats. Anim Sci J. 2009;80:562-9 pubmed publisher
    Licorice (Glycyrrhiza glabra) has been widely used in traditional medicines, and its flavonoid oil (LFO) decreases abdominal adipose tissue weight in mammals...
  33. Lee C, Park K, Lim S, Park J, Chung W. Effects of the licorice extract against tumor growth and cisplatin-induced toxicity in a mouse xenograft model of colon cancer. Biol Pharm Bull. 2007;30:2191-5 pubmed
    ..Therefore, the licorice extract may be a candidate for an anticancer and chemopreventive agent. However, cancer patients with cisplatin therapy should avoid the supplementation of the licorice extract...
  34. Zheng A, Moritani T. Effect of the combination of ginseng, oriental bezoar and glycyrrhiza on autonomic nervous activity and immune system under mental arithmetic stress. J Nutr Sci Vitaminol (Tokyo). 2008;54:244-9 pubmed
    ..Ginseng, oriental bezoar and glycyrrhiza have been used for Kampo (herbal treatment) for thousand years and a number of pharmacological and clinical ..
  35. Malekinejad H, Mirzakhani N, Razi M, Cheraghi H, Alizadeh A, Dardmeh F. Protective effects of melatonin and Glycyrrhiza glabra extract on ochratoxin A--induced damages on testes in mature rats. Hum Exp Toxicol. 2011;30:110-23 pubmed publisher
    The effect of Glycyrrhiza glabra extract (GgE) as a natural antioxidant and melatonin (MEL) on ochratoxin A (OTA)-induced histopathological damages on the testes and oxidative stress was evaluated in male rats...
  36. Fu Y, Chen J, Li Y, Zheng Y, Li P. Antioxidant and anti-inflammatory activities of six flavonoids separated from licorice. Food Chem. 2013;141:1063-71 pubmed publisher
    Licorice, the roots and rhizomes of several Glycyrrhiza species (Leguminosae), is an important natural sweetening agent and a widely used herbal medicine...
  37. Zwickey H, Brush J, Iacullo C, Connelly E, Gregory W, Soumyanath A, et al. The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD25 expression in humans: a pilot study. Phytother Res. 2007;21:1109-12 pubmed
    ..on T cells after ingestion of three commonly used herbs: Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra, administered singly and in combination...
  38. Hong Y, Wu H, Ma T, Liu W, He X. Effects of Glycyrrhiza glabra polysaccharides on immune and antioxidant activities in high-fat mice. Int J Biol Macromol. 2009;45:61-4 pubmed publisher
    The purpose of this study was to investigate the immune and antioxidant activities of Glycyrrhiza glabra polysaccharides (GGP) in rats fed high-fat diet. The experiment was performed on four groups of growing Kunming mice...
  39. Asha M, Debraj D, Prashanth D, Edwin J, Srikanth H, Muruganantham N, et al. In vitro anti-Helicobacter pylori activity of a flavonoid rich extract of Glycyrrhiza glabra and its probable mechanisms of action. J Ethnopharmacol. 2013;145:581-6 pubmed publisher
    b>Glycyrrhiza glabra Linn. is regarded useful for peptic ulcer in traditional systems of medicine in India and Helicobacter pylori has been considered as one of the causative factors for peptic ulcer...
  40. Simons R, Vincken J, Mol L, The S, Bovee T, Luijendijk T, et al. Agonistic and antagonistic estrogens in licorice root (Glycyrrhiza glabra). Anal Bioanal Chem. 2011;401:305-13 pubmed publisher
    The roots of licorice (Glycyrrhiza glabra) are a rich source of flavonoids, in particular, prenylated flavonoids, such as the isoflavan glabridin and the isoflavene glabrene...
  41. Zore G, Winston U, Surwase B, Meshram N, Sangle V, Kulkarni S, et al. Chemoprofile and bioactivities of Taverniera cuneifolia (Roth) Arn.: a wild relative and possible substitute of Glycyrrhiza glabra L. Phytomedicine. 2008;15:292-300 pubmed
    Chemoprofile of Taverniera cuneifolia (Roth) Arn. a wild relative of commercial licorice (Glycyrrhiza glabra L) is presented. Both T. cuneifolia and G. glabra L were found to be very similar phytochemically...
  42. Chin Y, Jung H, Liu Y, Su B, Castoro J, Keller W, et al. Anti-oxidant constituents of the roots and stolons of licorice (Glycyrrhiza glabra). J Agric Food Chem. 2007;55:4691-7 pubmed
    ..4'-O-methylglabridin, and paratocarpin B) (3-9) were isolated from the roots and stolons of licorice (Glycyrrhiza glabra)...
  43. Qiao X, Ye M, Xiang C, Wang Q, Liu C, Miao W, et al. Analytical strategy to reveal the in vivo process of multi-component herbal medicine: a pharmacokinetic study of licorice using liquid chromatography coupled with triple quadrupole mass spectrometry. J Chromatogr A. 2012;1258:84-93 pubmed publisher
    ..Licorice (Glycyrrhiza uralensis Fisch.), a most commonly used herbal medicine, was chosen as a model...
  44. Tabuchi M, Imamura S, Kawakami Z, Ikarashi Y, Kase Y. The blood-brain barrier permeability of 18?-glycyrrhetinic acid, a major metabolite of glycyrrhizin in Glycyrrhiza root, a constituent of the traditional Japanese medicine yokukansan. Cell Mol Neurobiol. 2012;32:1139-46 pubmed
    18?-Glycyrrhetinic acid (GA) is a major metabolite of glycyrrhizin (GL), which is one of the components of glycyrrhiza root, a constituent herb of the traditional Japanese medicine yokukansan...
  45. Hasanein P. Glabridin as a major active isoflavan from Glycyrrhiza glabra (licorice) reverses learning and memory deficits in diabetic rats. Acta Physiol Hung. 2011;98:221-30 pubmed publisher
    Cognitive impairment occurs in diabetes mellitus. Glabridin as a major active flavonoids in Glycyrrhiza glabra (licorice) improves learning and memory in mice...
  46. Cui Y, Ao M, Li W, Hu J, Yu L. Anti-inflammatory activity of licochalcone A isolated from Glycyrrhiza inflata. Z Naturforsch C. 2008;63:361-5 pubmed
    Licochalcone A was isolated from the roots of Glycyrrhiza inflata and evaluated for its anti-inflammatory activity in xylene-induced mice ear edema and carrageenan-induced paw edema tests...
  47. Visavadiya N, Soni B, Dalwadi N. Evaluation of antioxidant and anti-atherogenic properties of Glycyrrhiza glabra root using in vitro models. Int J Food Sci Nutr. 2009;60 Suppl 2:135-49 pubmed publisher
    The aim of present study was to evaluate antioxidant property of Glycyrrhiza glabra root extracts using in vitro models...
  48. Yin G, Cao L, Xu P, Jeney G, Nakao M, Lu C. Hepatoprotective and antioxidant effects of Glycyrrhiza glabra extract against carbon tetrachloride (CCl(4))-induced hepatocyte damage in common carp (Cyprinus carpio). Fish Physiol Biochem. 2011;37:209-16 pubmed publisher
    The present study is aiming at evaluating the hepatoprotective and antioxidant effects of Glycyrrhiza glabra extract (2.5, 5 and 10 ?g/ml) on the carbon tetrachloride (CCl(4))-induced carp hepatocyte damage in vitro...
  49. Chandrasekaran C, Deepak H, Thiyagarajan P, Kathiresan S, Sangli G, Deepak M, et al. Dual inhibitory effect of Glycyrrhiza glabra (GutGard™) on COX and LOX products. Phytomedicine. 2011;18:278-84 pubmed publisher
    b>Glycyrrhiza glabra and its phytoconstituents have been known to possess widespread pharmacological properties as an anti-inflammatory, anti-viral, antitumour and hepatoprotective drug...
  50. Li Y, Chen J, Li Y, Li Q, Zheng Y, Fu Y, et al. Screening and characterization of natural antioxidants in four Glycyrrhiza species by liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry. J Chromatogr A. 2011;1218:8181-91 pubmed publisher
    Licorice, derived from the dried roots and rhizomes of several species of genus Glycyrrhiza L. (Leguminosae family), has been traditionally used in herbal medicine for over 4000 years...
  51. Yu X, Xue C, Zhou Z, Li C, Du Y, Liang J, et al. In vitro and in vivo neuroprotective effect and mechanisms of glabridin, a major active isoflavan from Glycyrrhiza glabra (licorice). Life Sci. 2008;82:68-78 pubmed
    ..Glabridin, a major flavonoid of Glycyrrhiza glabra (licorice), possesses multiple pharmacological activities...
  52. Li L, Sinkko H, Montonen L, Wei G, Lindström K, Räsänen L. Biogeography of symbiotic and other endophytic bacteria isolated from medicinal Glycyrrhiza species in China. FEMS Microbiol Ecol. 2012;79:46-68 pubmed publisher
    A total of 159 endophytic bacteria were isolated from surface-sterilized root nodules of wild perennial Glycyrrhiza legumes growing on 40 sites in central and northwestern China...
  53. Kaur P, Kaur S, Kumar N, Singh B, Kumar S. Evaluation of antigenotoxic activity of isoliquiritin apioside from Glycyrrhiza glabra L. Toxicol In Vitro. 2009;23:680-6 pubmed publisher
    ..In search for lead molecules in cancer chemoprevention from natural products, a fraction 'Rlicca' isolated from Glycyrrhiza glabra was studied for modulatory effect against hydrogen peroxide and 4-nitroquinoline-N-oxide induced ..
  54. Aoki F, Nakagawa K, Kitano M, Ikematsu H, Nakamura K, Yokota S, et al. Clinical safety of licorice flavonoid oil (LFO) and pharmacokinetics of glabridin in healthy humans. J Am Coll Nutr. 2007;26:209-18 pubmed
    ..Glabridin is one of the bioactive flavonoids included specifically in licorice Glycyrrhiza glabra L. and is the most abundant flavonoid in LFO...
  55. Chowdhury B, Bhattamisra S, Das M. Anti-convulsant action and amelioration of oxidative stress by Glycyrrhiza glabra root extract in pentylenetetrazole- induced seizure in albino rats. Indian J Pharmacol. 2013;45:40-3 pubmed publisher
    The aim of the present study was to evaluate the anti-convulsant potential of aqueous and ethanol e xtract of Glycyrrhiza glabra (AEGG and EEGG) and its action on markers of oxidant stress in albino rats.
  56. Wittschier N, Faller G, Hensel A. Aqueous extracts and polysaccharides from liquorice roots (Glycyrrhiza glabra L.) inhibit adhesion of Helicobacter pylori to human gastric mucosa. J Ethnopharmacol. 2009;125:218-23 pubmed publisher
    Aqueous extracts from the roots of Glycyrrhiza glabra L. (Fabaceae) are widely used for treatment of stomach ulcer. The clinical proven effects are related to the presence of anti-inflammatory 12-keto-triterpensaponins in the extracts...
  57. Gao X, Wang W, Wei S, Li W. [Review of pharmacological effects of Glycyrrhiza radix and its bioactive compounds]. Zhongguo Zhong Yao Za Zhi. 2009;34:2695-700 pubmed
    b>Glycyrrhiza Radix is a commonly used Chinese herbal medicine, derived from the dried roots and rhizomes of Glycyrrhiza uralensis, G. glabra and G. inflata...