astragalus plant

Summary

Summary: A plant genus in the family FABACEAE, subfamily Papilionaceae, order Fabales, subclass Rosidae. Many of the species are associated with poisoning of grazing animals. Some of the species are used medicinally.

Top Publications

  1. Ma X, Shi Q, Duan J, Dong T, Tsim K. Chemical analysis of Radix Astragali (Huangqi) in China: a comparison with its adulterants and seasonal variations. J Agric Food Chem. 2002;50:4861-6 pubmed
    ..membranaceus var.mongholicus changed according to seasonal variation and age of the plant. The chemical composition of different species of Astragalus would provide useful information for the quality control of Radix Astragali...
  2. Tang D, He B, Zheng Z, Wang R, Gu F, Duan T, et al. Inhibitory effects of two major isoflavonoids in Radix Astragali on high glucose-induced mesangial cells proliferation and AGEs-induced endothelial cells apoptosis. Planta Med. 2011;77:729-32 pubmed publisher
    ..Therefore, the results obtained in this study suggest that both calycosin and calycosin-7-O-?-D-glucoside have a significant therapeutic potential to modulate the development and/or progression of diabetic nephropathy...
  3. Xu X, Ji H, Gu S, Shao Q, Huang Q, Cheng Y. Cardioprotective effects of Astragali Radix against isoproterenol-induced myocardial injury in rats and its possible mechanism. Phytother Res. 2008;22:389-94 pubmed
  4. Liu Q, Yao Y, Zhang S, Sheng Z. Astragalus polysaccharides regulate T cell-mediated immunity via CD11c(high)CD45RB(low) DCs in vitro. J Ethnopharmacol. 2011;136:457-64 pubmed publisher
    ..However, it is not yet clear whether APS can induce the activation and differentiation of dendritic cells (DCs) and subsequently activate T cells...
  5. Galeas M, Zhang L, Freeman J, Wegner M, Pilon Smits E. Seasonal fluctuations of selenium and sulfur accumulation in selenium hyperaccumulators and related nonaccumulators. New Phytol. 2007;173:517-25 pubmed
  6. Tin M, Cho C, Chan K, James A, Ko J. Astragalus saponins induce growth inhibition and apoptosis in human colon cancer cells and tumor xenograft. Carcinogenesis. 2007;28:1347-55 pubmed
  7. You H, Lu Y, Gui D, Peng A, Chen J, Gu Y. Aqueous extract of Astragali Radix ameliorates proteinuria in adriamycin nephropathy rats through inhibition of oxidative stress and endothelial nitric oxide synthase. J Ethnopharmacol. 2011;134:176-82 pubmed publisher
    ..To investigate the effects of aqueous extract of Astragali Radix (ARE) on the oxidative stress status and endothelial nitric oxide synthase level in adriamycin (ADR) nephropathy rats...
  8. Li J, Bao Y, Lam W, Li W, Lu F, Zhu X, et al. Immunoregulatory and anti-tumor effects of polysaccharopeptide and Astragalus polysaccharides on tumor-bearing mice. Immunopharmacol Immunotoxicol. 2008;30:771-82 pubmed
    ..These findings suggest that the immunomodulatory and anti-cancer effects of this new formula (PSP+APS) were better than those of PSP alone, and also could resist immunosuppression induced by AMD...
  9. Chan J, Lam F, Leung P, Che C, Fung K. Antihyperglycemic and antioxidative effects of a herbal formulation of Radix Astragali, Radix Codonopsis and Cortex Lycii in a mouse model of type 2 diabetes mellitus. Phytother Res. 2009;23:658-65 pubmed publisher
    ..The activities and expression of antioxidant enzymes, catalase and superoxide dismutase, were up-regulated when treated with SR10. Moreover, SR10 treatment did not exhibit any toxic effect to the host...

More Information

Publications83

  1. Cheng G, Li Y, Zhou J. Cloning and identification of opa22, a new gene involved in nodule formation by Mesorhizobium huakuii. FEMS Microbiol Lett. 2006;257:152-7 pubmed
    ..The complement stain HK24 was able to restore the nodule forming ability of the mutant...
  2. Mao X, Piao X, Lai C, Li D, Xing J, Shi B. Effects of beta-glucan obtained from the Chinese herb Astragalus membranaceus and lipopolysaccharide challenge on performance, immunological, adrenal, and somatotropic responses of weanling pigs. J Anim Sci. 2005;83:2775-82 pubmed
  3. Li S, Zhao X, Wang J. Synergy of Astragalus polysaccharides and probiotics (Lactobacillus and Bacillus cereus) on immunity and intestinal microbiota in chicks. Poult Sci. 2009;88:519-25 pubmed publisher
    ..05). The results showed that probiotics combined with APS administration in feed displayed synergistic modulation effects on immunity and intestinal microbiota, which is very important for the exploration of new prebiotics...
  4. Zhang R, Zhang X, Ruan Y, Ye S, Zhao H, Cheng Q, et al. Protective effect of Radix Astragali injection on immune organs of rats with obstructive jaundice and its mechanism. World J Gastroenterol. 2009;15:2862-9 pubmed
    ..To observe the protective effect of Radix Astragali injection on immune organs (lymph nodes, spleen and thymus) of rats with obstructive jaundice (OJ) and its mechanism...
  5. Qiu B, DU J, Shen D. [Mechanism of hepatocytes transdifferentiation to bile duct epithelial cells and intervention of huangqi decoction]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010;30:513-8 pubmed
    ..To investigate the mechanism of hepatocytes transdifferentiation to bile duct epithelial cells (BECs) and intervention of Huangqi decoction (HQD) on hepatic fibrosis formation in rats with secondary cholestasis...
  6. Huang X, Wang D, Hu Y, Lu Y, Guo Z, Kong X, et al. Effect of sulfated astragalus polysaccharide on cellular infectivity of infectious bursal disease virus. Int J Biol Macromol. 2008;42:166-71 pubmed
  7. DU J, Qiu B, Liu P, Sun M, Chen G, Liu J. [Huangqi decoction inhibits cholangiocyte proliferation and transdifferentiation in cholestatic liver fibrosis induced by BDL in rats]. Zhonghua Gan Zang Bing Za Zhi. 2010;18:13-8 pubmed publisher
    ..To elucidate the antifibrotic mechanism of Huangqi decoction in rats with BDL-induced cholestatic liver fibrosis...
  8. Li Q, Bao J, Li X, Zhang T, Shen X. Inhibiting effect of Astragalus polysaccharides on the functions of CD4+CD25 highTreg cells in the tumor microenvironment of human hepatocellular carcinoma. Chin Med J (Engl). 2012;125:786-93 pubmed
  9. Hong X, Zhang X, He X, Huang X, Chen H, Wang Y. [Effect of Astragalus mongholicus on renal gene expression profile in mice with diabetic nephropathy]. Zhongguo Zhong Yao Za Zhi. 2008;33:676-80 pubmed
    ..To study the effect of Astragalus mongholicus on renal gene expression profile in mice with diabetic nephropathy by cDNA microarray...
  10. Auyeung K, Cho C, Ko J. A novel anticancer effect of Astragalus saponins: Transcriptional activation of NSAID-activated gene. Int J Cancer. 2009;125:1082-91 pubmed publisher
    ..The information obtained could facilitate future development of a novel target-specific chemotherapeutic agent with known molecular pathway...
  11. Wang N, Zhang D, Mao X, Zou F, Jin H, Ouyang J. Astragalus polysaccharides decreased the expression of PTP1B through relieving ER stress induced activation of ATF6 in a rat model of type 2 diabetes. Mol Cell Endocrinol. 2009;307:89-98 pubmed publisher
  12. Liu X, Zhang C, Jin X, Li Y, Zheng X, Li L. Inhibitory effect of schisandrin B on gastric cancer cells in vitro. World J Gastroenterol. 2007;13:6506-11 pubmed
    ..To investigate the inhibitory effect and possible mechanism of action of schisandrin B in SC-B on gastric cancer cells in vitro...
  13. Zhang Y, Wu C, Cheng J. Merit of Astragalus polysaccharide in the improvement of early diabetic nephropathy with an effect on mRNA expressions of NF-kappaB and IkappaB in renal cortex of streptozotoxin-induced diabetic rats. J Ethnopharmacol. 2007;114:387-92 pubmed
  14. Freeman J, Zhang L, Marcus M, Fakra S, McGrath S, Pilon Smits E. Spatial imaging, speciation, and quantification of selenium in the hyperaccumulator plants Astragalus bisulcatus and Stanleya pinnata. Plant Physiol. 2006;142:124-34 pubmed
    ..The high concentration of Se in the plant periphery may contribute to Se tolerance and may also serve as an elemental plant defense mechanism...
  15. Sors T, Ellis D, Na G, Lahner B, Lee S, Leustek T, et al. Analysis of sulfur and selenium assimilation in Astragalus plants with varying capacities to accumulate selenium. Plant J. 2005;42:785-97 pubmed
  16. Freeman J, Lindblom S, Quinn C, Fakra S, Marcus M, Pilon Smits E. Selenium accumulation protects plants from herbivory by Orthoptera via toxicity and deterrence. New Phytol. 2007;175:490-500 pubmed
    ..Protection offered by organic selenium accumulation against these herbivores may have promoted the evolution of selenium hyperaccumulation in plants...
  17. Chen X, Bian Z, Lu S, Xu J, Gu C, Yang D, et al. Cardiac protective effect of Astragalus on viral myocarditis mice: comparison with Perindopril. Am J Chin Med. 2006;34:493-502 pubmed
    ..These results indicated that the beneficial effects of Astragalus and Perindopril for treating viral myocarditis might be partly mediated by preserving the functions of SERCA 2 activity and ET system...
  18. Xu D, Xia Q, Wang J, Wang P. Molecular weight and monosaccharide composition of Astragalus polysaccharides. Molecules. 2008;13:2408-15 pubmed
    ..45 and 1:6.25:17.86, respectively. The molecular weights (Mw) of APS-I and APS-II were 1,699,100 Da and 1,197,600 Da, respectively...
  19. Auyeung K, Woo P, Law P, Ko J. Astragalus saponins modulate cell invasiveness and angiogenesis in human gastric adenocarcinoma cells. J Ethnopharmacol. 2012;141:635-41 pubmed publisher
    ..In the present study, we further investigated the anti-angiogenic property of AST in human gastric adenocarcinoma cells (AGS) and attempted to elucidate the underlying mechanism...
  20. Yin X, Chen L, Liu Y, Yang J, Ma C, Yao Z, et al. Enhancement of the innate immune response of bladder epithelial cells by Astragalus polysaccharides through upregulation of TLR4 expression. Biochem Biophys Res Commun. 2010;397:232-8 pubmed publisher
    ..The findings establish the use of APS to modulate the innate immune response of the urinary tract through TLR4 expression regulation as an alternative option for UTI treatment...
  21. Zhao L, Ma Z, Zhu J, Yu X, Weng D. Characterization of polysaccharide from Astragalus radix as the macrophage stimulator. Cell Immunol. 2011;271:329-34 pubmed publisher
    ..Blocking NF-?B with specific inhibitor resulted in decreased levels of NO and TNF-?. The results suggested that APS possess potent immunomodulatory activity by stimulating macrophage and could be used as an immunotherapeutic adjuvant...
  22. El Mehdawi A, Pilon Smits E. Ecological aspects of plant selenium hyperaccumulation. Plant Biol (Stuttg). 2012;14:1-10 pubmed publisher
    ..Better ecological insight will also help in the management of seleniferous areas and the agricultural production of Se-rich crops for phytoremediation or biofortification...
  23. Cheng G, Li Y, Xie B, Yang C, Zhou J. Cloning and identification of lpsH, a novel gene playing a fundamental role in symbiotic nitrogen fixation of Mesorhizobium huakuii. Curr Microbiol. 2007;54:371-5 pubmed
    ..Plant studies showed that the lpsH gene mutant formed ineffective nodules, and this symbiotic phenotype was linked to abnormal nodule development...
  24. Lin Y, Wang B, Luo X. [Clinical study of astragalus's preventing the recurrence of asthma in children]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011;31:1090-2 pubmed
    ..To study the clinical efficacy of astragalus's preventing the recurrence and regulatory effects on Th1/Th2 cytokines in asthmatic children during the remission stage...
  25. Zuo C, Xie X, Deng Y, Fan J. [Effect of Astragalus mongholicus on expression of transforming growth factor- beta1 in SD rats with unilateral ureteral occlusion]. Zhongguo Zhong Yao Za Zhi. 2009;34:193-8 pubmed
  26. Gao G, Li Q, Shen H. Effect of Astragali-Cordyceps Mixtura on TGF-beta/Smad signal pathway in the lung of asthma airway remodeling. J Ethnopharmacol. 2009;125:68-74 pubmed publisher
    ..We try to find out the influence of traditional Chinese Medicine Astragali-Cordyceps Mixtura (ACM) on TGF-beta/Smad signal pathway in the lung of asthma airway remodeling...
  27. Dang S, Jia X, Song P, Cheng Y, Zhang X, Sun M, et al. Inhibitory effect of emodin and Astragalus polysaccharide on the replication of HBV. World J Gastroenterol. 2009;15:5669-73 pubmed
    ..To evaluate the anti-viral effect of emodin plus Astragalus polysaccharide (APS) in hepatitis B virus (HBV) transgenic mice...
  28. Cui R, He J, Wang B, Zhang F, Chen G, Yin S, et al. Suppressive effect of Astragalus membranaceus Bunge on chemical hepatocarcinogenesis in rats. Cancer Chemother Pharmacol. 2003;51:75-80 pubmed
    ..The formation of GST-P-positive foci and the expression of GST-P protein and mRNA caused by DEN-PH-AAF were reduced in the treatment groups, which clearly suggests that AM is effective in delaying DEN-PH-AAF-induced hepatocarcinogenesis...
  29. Shon Y, Nam K. Protective effect of Astragali radix extract on interleukin 1beta-induced in fl ammation in human amnion. Phytother Res. 2003;17:1016-20 pubmed
    ..These results indicate that Astragali radix has a broad antiinflammatory effect in human amnion and may be considered a promising agent to protect preterm labour...
  30. Yesilada E, Bedir E, Calis I, Takaishi Y, Ohmoto Y. Effects of triterpene saponins from Astragalus species on in vitro cytokine release. J Ethnopharmacol. 2005;96:71-7 pubmed
    ..Accordingly, the IL-2 inducing activity of the triterpene saponins might be the mechanism involved in order to explain the immunomodulatory and anticancer effects of Astragalus species...
  31. Li X, Chen D, Mai Y, Wen B, Wang X. Concordance between antioxidant activities in vitro and chemical components of Radix Astragali (Huangqi). Nat Prod Res. 2012;26:1050-3 pubmed publisher
    ..This large difference clearly demonstrates that the antioxidant effects of RA in vitro might be generally considered to be a result of the presence of phenolic compounds (including flavonoids) but not astragalosides and polysaccharides. ..
  32. Crone E, Polansky L, Lesica P. Empirical models of pollen limitation, resource acquisition, and mast seeding by a bee-pollinated wildflower. Am Nat. 2005;166:396-408 pubmed
    ..scaphoides. Precipitation does not act as a direct cue for synchrony in this species but might affect long-term resource gain and fruiting dynamics. ..
  33. Tan G, Jing J, Zhu Z, Lou Z, Li W, Zhao L, et al. Detection and identification of diterpenoid alkaloids, isoflavonoids and saponins in Qifu decoction and rat plasma by liquid chromatography-time-of-flight mass spectrometry. Biomed Chromatogr. 2012;26:178-91 pubmed publisher
    ..The experimental data indicated that the decocting process could result in differences in the amounts of active components. ..
  34. El Mawla A. Production of cycloartane triterpene glycosides in shoot cultures of Astragalus sieberi DC. Nat Prod Res. 2010;24:416-22 pubmed publisher
    ..5 mg L(-1) each of NAA and BA. The isolated cycloastragenol-3-O-glucoside was identified by spectral analysis and compared with an authentic sample. ..
  35. Teyeb H, Zouari S, Douki W, Najjar M, Neffati M. Variation in volatiles of Astragalus gombiformis Pomel. Z Naturforsch C. 2011;66:1-6 pubmed
    ..This study is the first report on the chemical composition of essential oils from A. gombiformis and indicates that these oils should be more studied. ..
  36. Naghiloo S, Dadpour M, Movafeghi A. Floral ontogeny in Astragalus compactus (Leguminosae: Papilionoideae: Galegeae): variable occurrence of bracteoles and variable patterns of sepal initiation. Planta. 2012;235:793-805 pubmed publisher
    ..Relationships between mechanical force and auxin signalling are discussed. ..
  37. Jalsrai A, Grecksch G, Becker A. Evaluation of the effects of Astragalus mongholicus Bunge saponin extract on central nervous system functions. J Ethnopharmacol. 2010;131:544-9 pubmed publisher
    ..The mechanisms underlying this effect on hippocampal morphology are not yet understood. ..
  38. Yu D, Bao Y, Wei C, An L. Studies of chemical constituents and their antioxidant activities from Astragalus mongholicus Bunge. Biomed Environ Sci. 2005;18:297-301 pubmed
    ..Compound II, VI, and VII are first reported in this plant. Calycosin exhibits the most potent antioxidant activity both in the cell-free system and in the cell system. ..
  39. Cakir O, Candar Cakir B, Zhang B. Small RNA and degradome sequencing reveals important microRNA function in Astragalus chrysochlorus response to selenium stimuli. Plant Biotechnol J. 2016;14:543-56 pubmed publisher
  40. Zheng Y, Jin Y, Zhu H, Xu S, Xia Y, Huang Y. Effects of a Chinese medicinal plant Radix astragali on the ovariectomized female rats. Afr J Tradit Complement Altern Med. 2012;10:9-14 pubmed
    ..05). It is concluded that RA can significantly improve the immune functions of the ovariectomized female rats, although it cannot change the sex hormones levels as significantly as estrogen. ..
  41. Chen W, Xia Y, Chen W, Yu M, Li Y, Ye H. Improvement of myocardial glycolipid metabolic disorder in diabetic hamster with Astragalus polysaccharides treatment. Mol Biol Rep. 2012;39:7609-15 pubmed publisher
    ..APS can partially improve myocardial glucose and lipid metabolism disorders in diabetic hamsters and protect myocardium in some extent. ..
  42. Zhou Q, Ye Z, Ruan Z, Zeng S. Investigation on modulation of human P-gp by multiple doses of Radix Astragali extract granules using fexofenadine as a phenotyping probe. J Ethnopharmacol. 2013;146:744-9 pubmed publisher
    ..Further investigations are necessary in patients who receive long-term use of RA extract formulation and combined P-gp substrates, especially in those ABCB1 3435CC carriers. ..
  43. Alijani S, Balaghi S, Mohammadifar M. Effect of gamma irradiation on rheological properties of polysaccharides exuded by A. fluccosus and A. gossypinus. Int J Biol Macromol. 2011;49:471-9 pubmed publisher
    ..The notable changes in functional properties of each variety of irradiated gum should be taken into consideration before using the radiation technology as a commercial tool for sterilisation. ..
  44. Chunmei K, Zhujun Z, Xiuhui Z. Effects of Gan lian Yu ping feng powder on the antibody titers to infectious laryngotracheitis vaccine and some nonspecific immune indexes in chickens. Afr J Tradit Complement Altern Med. 2013;10:70-7 pubmed
    ..01) and the immune organ index (P<0.05). The results indicate that Gan lian Yu ping feng powder effectively improves the immunity in chickens. ..
  45. Ding W, Li J, Chai Z. [Culture-filtrate producing condition and biological activity of Fusarium solani]. Zhongguo Zhong Yao Za Zhi. 2009;34:2571-6 pubmed
    ..The best condition for F. solani to produce toxin was that it was cultured in PSC liquid medium, in dark, at 25 degrees C for 12 d. The toxin produced by isolate HQM40 was non-host specific toxin. ..
  46. Yang C, Wang Q, Guo Y. Pollination in a patchily distributed lousewort is facilitated by presence of a co-flowering plant due to enhancement of quantity and quality of pollinator visits. Ann Bot. 2013;112:1751-8 pubmed publisher
    ..Plants surrounded by individuals of other co-flowering species may suffer a reproductive cost from interspecific pollen transfer (IPT). However, differences in floral architecture may reduce or eliminate IPT...
  47. Wang Y, Ji Y, Xing Y, Li X, Gao X. Astragalosides rescue both cardiac function and sarcoplasmic reticulum Ca²? transport in rats with chronic heart failure. Phytother Res. 2012;26:231-8 pubmed publisher
    ..Rescue of sarcoplasmic reticulum Ca²? cycling by astragalosides could normalize excitation-contraction coupling and improve overall cardiac function. ..
  48. Jiang J, Wu C, Gao H, Song J, Li H. Effects of astragalus polysaccharides on immunologic function of erythrocyte in chickens infected with infectious bursa disease virus. Vaccine. 2010;28:5614-6 pubmed publisher
    ..The results suggest that the immunological function of chicken erythrocytes declines after infected with IBDV and APS obviously enhances the immunological function of chicken erythrocytes. ..
  49. Tanaka K, Tamura T, Fukuda S, Batkhuu J, Sanchir C, Komatsu K. Quality evaluation of Astragali Radix using a multivariate statistical approach. Phytochemistry. 2008;69:2081-7 pubmed publisher
  50. Xiping Z, Ke W, Yaping Y, Hongchan Z, Qihui C. Protective effect and mechanisms of radix astragali injection on the intestinal mucosa of rats with obstructive jaundice. Mediators Inflamm. 2010;2010:757191 pubmed publisher
    ..To research the protective effects and mechanisms of Radix Astragali injection on the intestinal mucosa of rats with obstructive jaundice (OJ)...
  51. Yuan L, Hua C, Gao S, Yin Y, Dai M, Meng H, et al. Astragalus Polysaccharides Attenuate Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats. Am J Chin Med. 2017;45:773-789 pubmed publisher
    ..In couclusion, APS ameliorates MCT-induced pulmonary artery hypertension by inhibiting pulmonary arterial remodeling partially via eNOS/NO and NF-[Formula: see text]B signaling pathways. ..
  52. Li D, Chen Q, Yi L. [Effects of yiqi huoxue method on cardiac function in patients with congestive heart failure]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006;26:552-4 pubmed
    ..To compare the clinical effect of three TCM therapeutic methods, Yiqi (YQ, supplementing Qi), Huoxue (HX, activating blood circulation) and Yiqi Huoxue (YQHX) method on congestive heart failure and heart function...
  53. Mehdawi A, Cappa J, Fakra S, Self J, Pilon Smits E. Interactions of selenium hyperaccumulators and nonaccumulators during cocultivation on seleniferous or nonseleniferous soil--the importance of having good neighbors. New Phytol. 2012;194:264-77 pubmed publisher
    ..pinnata. • Thus, plants can affect Se accumulation in neighbors, and soil Se affects competition and facilitation between plants. This helps to explain why hyperaccumulators are found predominantly on seleniferous soils...
  54. Xing R, Zhou K, Song J. [Pharmacokinetics behavior of raltitrexed in rats after single injected with astragali radix]. Zhongguo Zhong Yao Za Zhi. 2013;38:1823-6 pubmed
    ..Between RTX and RTX with RA groups, half-life (t1/2), AUC(0-t) and CL showed no statistically significant differences; RA co-administration did not affect the pharmacokinetics of raltitrexed...
  55. Gompert Z, Fordyce J, Forister M, Shapiro A, Nice C. Homoploid hybrid speciation in an extreme habitat. Science. 2006;314:1923-5 pubmed
    ..As predicted, adaptive traits may allow for persistence in the environmentally extreme alpine habitat and reproductively isolate these populations from their parental species...
  56. Pu X, Ma X, Liu L, Ren J, Li H, Li X, et al. Structural characterization and antioxidant activity in vitro of polysaccharides from angelica and astragalus. Carbohydr Polym. 2016;137:154-164 pubmed publisher
    ..AAP-2A exhibited a surface with a sheet-like appearance in scanning electron microscope and stronger antioxidant capacity compared with AAP. ..
  57. Bagheri A, Maassoumi A, Rahiminejad M, Blattner F. Molecular Phylogeny and Morphological Analysis Support a New Species and New Synonymy in Iranian Astragalus (Leguminosae). PLoS ONE. 2016;11:e0149726 pubmed publisher
    ..Also the placement of A. sciureus var. subsessilis was found to be wrong and this taxon should be treated as a synonym within A. kohrudicus. ..
  58. Lu L, Wang D, Shi Y, Yin Y, Wei L, Zou Y, et al. Astragalus polysaccharide improves muscle atrophy from dexamethasone- and peroxide-induced injury in vitro. Int J Biol Macromol. 2013;61:7-16 pubmed publisher
    ..Moreover, Antioxidant effect of APS was also detected in this work. Our findings suggested that APS could be explored as a protective and perhaps as a therapeutic agent in the management of muscle wasting...
  59. Xie X, Huang W, Liu F, Tang N, Liu Y, Lin H, et al. Functional analysis of the novel mycorrhiza-specific phosphate transporter AsPT1 and PHT1 family from Astragalus sinicus during the arbuscular mycorrhizal symbiosis. New Phytol. 2013;198:836-52 pubmed publisher
    ..AsPT4 but not AsPT1 is required for symbiotic Pi uptake. These results suggest that both, AsPT1 and AsPT4, are required for the AM symbiosis, most importantly, AsPT1 may serve as a novel symbiotic transporter for AM development...
  60. Song M, Chen Y, Du H, Zhang S, Wang Y, Zeng L, et al. RAW REHMANNIA RADIX POLYSACCHARIDE CAN EFFECTIVELY RELEASE PEROXIDATIVE INJURY INDUCED BY DUCK HEPATITIS A VIRUS. Afr J Tradit Complement Altern Med. 2017;14:8-21 pubmed publisher
    ..Duck viral hepatitis (DVH), caused by duck hepatitis A virus (DHAV), is a fatal contagious infectious disease which spreads rapidly with high morbidity and high mortality, and there is no effective clinical drug against DVH...
  61. Wei W, Xiao H, Bao W, Ma D, Leung C, Han X, et al. TLR-4 may mediate signaling pathways of Astragalus polysaccharide RAP induced cytokine expression of RAW264.7 cells. J Ethnopharmacol. 2016;179:243-52 pubmed publisher
    ..These results are helpful to better understand the immunomodulating effects of Radix Astragali. RAP may induce cytokine production of RAW264.7 cells through TLR4-mediated activation of MAPKs and NF-κB. ..
  62. Xiao W, Motley T, Unachukwu U, Lau C, Jiang B, Hong F, et al. Chemical and genetic assessment of variability in commercial Radix Astragali (Astragalus spp.) by ion trap LC-MS and nuclear ribosomal DNA barcoding sequence analyses. J Agric Food Chem. 2011;59:1548-56 pubmed publisher
    ..e., point of purchase) factors were considered. Therefore, chemical profiles determined by LC-MS and DNA profiles in ITS spacer domains could serve as barcode markers for quality control of Radix Astragali...
  63. Zhang X, Xiao H, Xue X, Sun Y, Liang X. Simultaneous characterization of isoflavonoids and astragalosides in two Astragalus species by high-performance liquid chromatography coupled with atmospheric pressure chemical ionization tandem mass spectrometry. J Sep Sci. 2007;30:2059-69 pubmed
    ..membranaceus for the first time and five IFs were firstly identified in A. mongholicus. The results indicate that HPLC-APCI-MS/MS is a powerful tool for the simultaneous characterization of IFs and AGs in complex matrix...
  64. Zuo C, Xie X, Deng Y, Fan J. [Effect of Astragalus mongholicus on expression of connective tissue growth factor in kidney of SD rats with unilateral ureteral obstruction]. Zhong Yao Cai. 2008;31:1185-90 pubmed
    ..To study the effect of Astrangalus mongholicus (AM) on the expression of Connective Tissue Growth Factor (CTGF) in SD rats with Unilateral Ureteral Obstruction (UUO) and elucidate the mechanism underlying the renorotective effects of AM...
  65. Meng L, Van Putten V, Qu L, Nemenoff R, Shang M, Cai S, et al. Altered expression of genes profiles modulated by a combination of Astragali Radix and Angelicae Sinensis Radix in obstructed rat kidney. Planta Med. 2010;76:1431-8 pubmed publisher
  66. Lu J, Chen X, Zhang Y, Xu J, Zhang L, Li Z, et al. Astragalus polysaccharide induces anti-inflammatory effects dependent on AMPK activity in palmitate-treated RAW264.7 cells. Int J Mol Med. 2013;31:1463-70 pubmed publisher
    ..These results suggest that APS effectively ameliorates palmitate-induced pro-inflammatory responses through AMPK activity...
  67. Yu Y, Wang S, Nie B, Sun Y, Yan Y, Zhu L. [Effect of Astragali Radix injection on myocardial cell mitochondrial structure and function in process of reversing myocardial cell hypertrophy]. Zhongguo Zhong Yao Za Zhi. 2012;37:979-84 pubmed
    ..To study pathological and therapeutical problems concerning myocardial cell mitochondria changes during myocardial cell hypertrophy by culturing rat primary myocardial cells...
  68. Hu G, Siu S, Li S, Chu I, Kwan Y, Chan S, et al. Metabolism of calycosin, an isoflavone from Astragali Radix, in zebrafish larvae. Xenobiotica. 2012;42:294-303 pubmed publisher
  69. Yi Y, Li S, Nie Y, Jia D, Zhang Z, Wang Y, et al. Effect of astragalus injection on renal tubular epithelial transdifferentiation in type 2 diabetic mice. BMC Complement Altern Med. 2016;16:222 pubmed publisher
    ..Administration of astragalus likely prevents or mitigates DN by suppressing tubular epithelial transdifferentiation, protecting KKAy mice from renal damage. ..
  70. Liu Y, Zhang X, Zhao Y, Chen H, Wang B, Zhang Q. Comparative chemical analysis of Radix Astragali and Radix Hedysari by HPLC. Nat Prod Res. 2012;26:1935-8 pubmed
    ..The similarities and differences of the chemicals may be responsible, at least partially, for the similarities and differences in their efficacies or bioactivities...
  71. Du Q, Zhang X, Song F, Liu Z, Liu S. [Change of the content of chemical constituents and anti-oxidative action of the decoction of radix ginseng combined with Flos Lonicerae, radix Polygoni Multiflori and Radix Astragali]. Yao Xue Xue Bao. 2010;45:756-60 pubmed
    ..The experimental results showed that antioxidative activity was better in the combinative decoction than that in single decoction, and the FRAP values of n-butanol extract were also greater compared with that of water extract...
  72. Zhang M, Kang Y, Zhou L, Podlech D. Phylogenetic origin of Phyllolobium with a further implication for diversification of Astragalus in China. J Integr Plant Biol. 2009;51:889-99 pubmed publisher
    ..Robusti) was estimated to originate 2.5 million years ago and this section with a tendency for dry habitats seems to be evidence of Asian intensified aridity resulting from the intense uplift of the Qinghai-Tibetan Plateau...
  73. Lau K, Lai K, Liu C, Tam J, To M, Kwok H, et al. Synergistic interaction between Astragali Radix and Rehmanniae Radix in a Chinese herbal formula to promote diabetic wound healing. J Ethnopharmacol. 2012;141:250-6 pubmed publisher
    ..Astragali Radix (AR) and Rehmanniae Radix (RR) are two traditional Chinese medicines widely used in China for treating diabetes mellitus and its complications, such as diabetic foot ulcer...
  74. Qi L, Liu C, Wu W, Gu Z, Guo C. Protective effect of flavonoids from Astragalus complanatus on radiation induced damages in mice. Fitoterapia. 2011;82:383-92 pubmed publisher
    ..Eleven monomers of the FAC were analyzed by HPLC. These results seem to support the use of FAC in relieving radiation damage...