abrus

Summary

Summary: A plant genus of the family FABACEAE whose members contain the highly toxic compound ABRIN.

Top Publications

  1. Menezes R, Rao P, Baliga B, Arya A, Jain A, Manipady S. Abrus precatorius poisoning. J Assoc Physicians India. 2007;55:458 pubmed
  2. Tripathi S, Maiti T. Stimulation of murine macrophages by native and heat-denatured lectin from Abrus precatorius. Int Immunopharmacol. 2003;3:375-81 pubmed
    ..evaluated the immunostimulant activity of native agglutinin (NA) and heat-denatured agglutinin (HDA) obtained from Abrus precatorius seed kernels on murine macrophages...
  3. Silva A, Horta A, Moreira R, Beltramini L, Araujo A. Production of Abrus pulchellus ribosome-inactivating protein from seeds callus culture. Toxicon. 2003;41:841-9 pubmed
    Ribosome inactivating proteins (RIPs) were isolated from callus culture that were established from seed explants of Abrus pulchellus...
  4. Ramnath V, Kuttan G, Kuttan R. Effect of abrin on cell-mediated immune responses in mice. Immunopharmacol Immunotoxicol. 2006;28:259-68 pubmed
    Effect of abrin isolated from Abrus precatorius on the cellular immune responses was studied in normal as well as tumor-bearing animals...
  5. Jang D, Hoffman R, Nelson L. Attempted suicide, by mail order: Abrus precatorius. J Med Toxicol. 2010;6:427-30 pubmed publisher
    b>Abrus precatorius is cultivated in many subtropical areas. The seeds exist in a variety of colors such as black, orange, and most commonly, glossy red. A black band is found at the end of the seed...
  6. Rahman A, Samoylenko V, Jain S, Tekwani B, Khan S, Jacob M, et al. Antiparasitic and antimicrobial isoflavanquinones from Abrus schimperi. Nat Prod Commun. 2011;6:1645-50 pubmed
    The EtOH extract of Abrus schimperi (Fabaceae), collected in Kenya, demonstrated significant activity against Leishmania donovani promastigotes with IC50 value of 3.6 microg/mL...
  7. Adelowotan O, Aibinu I, Adenipekun E, Odugbemi T. The in-vitro antimicrobial activity of Abrus precatorius (L) fabaceae extract on some clinical pathogens. Niger Postgrad Med J. 2008;15:32-7 pubmed
    To investigate the in-vitro antimicrobial activities of the extracts of Abrus precatorius on some clinical isolates as resistance to available and affordable antibiotics by these pathogens is on the increase.
  8. Goto L, Beltramini L, de Moraes D, Moreira R, de Araújo A. Abrus pulchellus type-2 RIP, pulchellin: heterologous expression and refolding of the sugar-binding B chain. Protein Expr Purif. 2003;31:12-8 pubmed
    b>Abrus pulchellus type-2 RIP, or pulchellin, is a heterodimeric glycoprotein found in A. pulchellus seeds...
  9. Bhutia S, Mallick S, Stevens S, Prokai L, Vishwanatha J, Maiti T. Induction of mitochondria-dependent apoptosis by Abrus agglutinin derived peptides in human cervical cancer cell. Toxicol In Vitro. 2008;22:344-51 pubmed
    In our previous study, Abrus agglutinin showed antitumor activity both native and heat-denatured condition in mouse model...

More Information

Publications76

  1. Fernando C. Poisoning due to Abrus precatorius (jequirity bean). Anaesthesia. 2001;56:1178-80 pubmed
    The management of a patient with poisoning due to ingestion of the jequirity bean (Abrus precatorius) is presented...
  2. Tilwari A, Shukla N, Pathirissery U. Immunomodulatory activity of the aqueous extract of seeds of Abrus precatorius Linn (Jequirity) in mice. Iran J Immunol. 2011;8:96-103 pubmed publisher
    ..Various compounds of plant origin have been widely investigated since ancient times for their possible immunomodulatory properties as well as for the treatment of a wide range of diseases...
  3. Taur D, Patil R. Mast cell stabilizing and antiallergic activity of Abrus precatorius in the management of asthma. Asian Pac J Trop Med. 2011;4:46-9 pubmed publisher
    To investigate effects of ethanol extract of Abrus precatorius leaves (EAPL) on egg albumin induced mast cell degranulation in mice and passive cutaneous anaphylaxis in rats...
  4. Bhutia S, Mallick S, Maiti S, Mishra D, Maiti T. Abrus abrin derived peptides induce apoptosis by targeting mitochondria in HeLa cells. Cell Biol Int. 2009;33:720-7 pubmed publisher
    In our previous study, Abrus abrin derived peptide fraction (ABP) with molecular weight in range of 600-1500Da was shown to have potent antitumor activity in Dalton's lymphoma (DL) tumor bearing mice...
  5. Hata Y, Raith M, Ebrahimi S, Zimmermann S, Mokoka T, Naidoo D, et al. Antiprotozoal isoflavan quinones from Abrus precatorius ssp. africanus. Planta Med. 2013;79:492-8 pubmed publisher
    ..A CH2Cl2/MeOH (1 : 1) extract of Abrus precatorius L. ssp. africanus strongly inhibited P. falciparum (98 %), T. b. rhodesiense (100 %), and L...
  6. Bagaria A, Surendranath K, Ramagopal U, Ramakumar S, Karande A. Structure-function analysis and insights into the reduced toxicity of Abrus precatorius agglutinin I in relation to abrin. J Biol Chem. 2006;281:34465-74 pubmed
    Abrin and agglutinin-I from the seeds of Abrus precatorius are type II ribosome-inactivating proteins that inhibit protein synthesis in eukaryotic cells...
  7. Limmatvapirat C, Sirisopanaporn S, Kittakoop P. Antitubercular and antiplasmodial constituents of Abrus precatorius. Planta Med. 2004;70:276-8 pubmed
    ..abruquinone B ( 1), and a new derivative, abruquinone G ( 2), were isolated from the aerial parts of Abrus precatorius. Chemical structures of these compounds were elucidated by spectral analyses...
  8. Tripathi S, Maiti T. Immunomodulatory role of native and heat denatured agglutinin from Abrus precatorius. Int J Biochem Cell Biol. 2005;37:451-62 pubmed
    ..b>Abrus agglutinin, similar to ML-1 with respect to carbohydrate specificity [gal (beta1-->3) gal/Nac], was studied ..
  9. Ramnath V, Kuttan G, Kuttan R. Immunopotentiating activity of abrin, a lectin from Abrus precatorius Linn. Indian J Exp Biol. 2002;40:910-3 pubmed
    ..The results suggest that abrin can potentiate the humoral immune response of the host...
  10. Bhutia S, Mallick S, Maiti S, Maiti T. Inhibitory effect of Abrus abrin-derived peptide fraction against Dalton's lymphoma ascites model. Phytomedicine. 2009;16:377-85 pubmed publisher
    ..It has been reported that Abrus abrin, isolated from the seeds of Abrus precatorius, showed in vitro and in vivo antitumor properties by the ..
  11. Reyes L, Nobre T, Pavinatto F, Zaniquelli M, Caseli L, Oliveira O, et al. The role of the C-terminal region of pulchellin A-chain in the interaction with membrane model systems. Biochim Biophys Acta. 2012;1818:82-9 pubmed publisher
    ..These results confirm the importance of the C-terminal region for PAC-ER membrane interaction. The partial unfolding only with preserved C-terminal appears a key step for the protein to reach the cytosol and develop its toxic activity...
  12. Wu A, Wu J, Liu J, Chen Y, Singha B, Chow L, et al. Roles of mammalian structural units, ligand cluster and polyvalency in the Abrus precatorius agglutinin and glycoprotein recognition process. Mol Immunol. 2009;46:3427-37 pubmed publisher
    Previous studies on one of the toxic type 2 ribosome inactivating proteins (RIP), Abrus precatorius agglutinin (APA), have shown that the recognition domains of APA are restricted to monomers of Galbeta1-3GalNAc (T, Thomsen-Friedenreich ..
  13. Ghosh D, Bhutia S, Mallick S, Banerjee I, Maiti T. Stimulation of murine B and T lymphocytes by native and heat-denatured Abrus agglutinin. Immunobiology. 2009;214:227-34 pubmed publisher
    In our previous studies, Abrus agglutinin showed non-specific immunostimulatory activity both native (NA) and heat-denatured (HDA) condition in mouse model...
  14. Zore G, Awad V, Thakre A, Halde U, Meshram N, Surwase B, et al. Activity-directed fractionation and isolation of four antibacterial compounds from Abrus precatorius L. roots. Nat Prod Res. 2007;21:933-40 pubmed
    Root extracts of the plant Abrus precatorius L. was tested for antibacterial activity. Various solvent fractions exhibited inhibitory activity against 13 gram-positive and gram-negative bacteria...
  15. Bhutia S, Mallick S, Maiti T. In vitro immunostimulatory properties of Abrus lectins derived peptides in tumor bearing mice. Phytomedicine. 2009;16:776-82 pubmed publisher
    In vitro immunostimulatory effect of Abrus lectins derived peptide fractions (AGP and ABP) was investigated in DL bearing mice...
  16. Igarashi Y, Ogura H, Furihata K, Oku N, Indananda C, Thamchaipenet A. Maklamicin, an antibacterial polyketide from an endophytic Micromonospora sp. J Nat Prod. 2011;74:670-4 pubmed publisher
    ..Maklamicin (1) showed strong to modest antimicrobial activity against Gram-positive bacteria...
  17. Wang H, Jiang Z, Du H, Liang C, Wang Y, Zhang M, et al. Simultaneous determination of three flavonoid C-glycosides in mice biosamples by HPLC-ESI-MS method after oral administration of Abrus mollis extract and its application to biodistribution studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2012;903:68-74 pubmed publisher
    ..method was developed for the determination of vicenin-2 (1), isoschaftoside (2), and schaftoside (3) of Abrus mollis extract in mice plasma and tissues (heart, liver, spleen, lungs, and kidneys)...
  18. Amujoyegbe O, Idu M, Agbedahunsi J, Erhabor J. Ethnomedicinal survey of medicinal plants used in the management of sickle cell disorder in Southern Nigeria. J Ethnopharmacol. 2016;185:347-60 pubmed publisher
    ..69 and 0.64 respectively. Plants with the least use value (0.001) include Abrus canescens, Acacia xanthophloea, Aerva lanata and Axonopus compressus...
  19. Tiwari V, Bagaria S, Karande A. A chimeric protein of abrin and Abrus precatorius agglutinin that neutralizes abrin mediated lethality in mice. Toxicon. 2017;127:122-129 pubmed publisher
    Abrin, a type II ribosome inactivating protein from the Abrus precatorius plant, is extremely toxic...
  20. Taur D, Patil R, Patil R. Antiasthmatic related properties of Abrus precatorius leaves on various models. J Tradit Complement Med. 2017;7:428-432 pubmed publisher
    ..i>Abrus precatorius Linn (Fabacease) is a climbing shrub...
  21. Panda P, Naik P, Meher B, Das D, Mukhopadhyay S, Praharaj P, et al. PUMA dependent mitophagy by Abrus agglutinin contributes to apoptosis through ceramide generation. Biochim Biophys Acta Mol Cell Res. 2018;1865:480-495 pubmed publisher
    ..In this study, we reported mitophagy inducing potential of PUMA triggered by phytolectin Abrus agglutinin (AGG) in U87MG glioblastoma cells and established AGG-induced ceramide acts as the chief mediator of ..
  22. Hansbauer E, Worbs S, Volland H, Simon S, Junot C, Fenaille F, et al. Rapid Detection of Abrin Toxin and Its Isoforms in Complex Matrices by Immuno-Extraction and Quantitative High Resolution Targeted Mass Spectrometry. Anal Chem. 2017;89:11719-11727 pubmed publisher
    Abrin expressed by the tropical plant Abrus precatorius is highly dangerous with an estimated human lethal dose of 0.1-1 ?g/kg body weight. Due to the potential misuse as a biothreat agent, abrin is in the focus of surveillance...
  23. Yu Y, Yang R, Zhao X, Qin D, Liu Z, Liu F, et al. Abrin P2 suppresses proliferation and induces apoptosis of colon cancer cells via mitochondrial membrane depolarization and caspase activation. Acta Biochim Biophys Sin (Shanghai). 2016;48:420-9 pubmed publisher
    ..the cytotoxic mechanism of abrin P2 on human colon cancer HCT-8 cells, abrin P2 was isolated from the seed of Abrus precatorius L. It was found that abrin P2 exhibited cytotoxicity toward 12 different human cancer cell lines...
  24. TAM C, Henderson T, Stanker L, He X, Cheng L. Abrin Toxicity and Bioavailability after Temperature and pH Treatment. Toxins (Basel). 2017;9: pubmed publisher
    Abrin, one of most potent toxins known to man, is derived from the rosary pea (jequirity pea), Abrus precatorius and is a potential bioterror weapon...
  25. He X, Patfield S, Cheng L, Stanker L, Rasooly R, McKeon T, et al. Detection of Abrin Holotoxin Using Novel Monoclonal Antibodies. Toxins (Basel). 2017;9: pubmed publisher
    Abrin, a member of the ribosome-inactivating protein family, is produced by the Abrus precatorius plant. Having the potential to pose a severe threat to both human and animal health, abrin is classified as a Select Agent by the U...
  26. Sadraeian M, Guimarães F, Araújo A, Worthylake D, LeCour L, Pincus S. Selective cytotoxicity of a novel immunotoxin based on pulchellin A chain for cells expressing HIV envelope. Sci Rep. 2017;7:7579 pubmed publisher
    ..The toxin pulchellin, isolated from the Abrus pulchellus plant, has similar structure and function as ricin...
  27. Jeong Y, Park J, Kim D, Kang J, Kim H. Anti-inflammatory mechanism of lonchocarpine in LPS- or poly(I:C)-induced neuroinflammation. Pharmacol Res. 2017;119:431-442 pubmed publisher
    ..In this study, we investigated the anti-inflammatory effects of lonchocarpine, a natural compound isolated from Abrus precatorius, under in vitro and in vivo neuroinflammatory conditions induced by challenge with lipopolysaccharide (..
  28. Serge N, Laurette Blandine M, Kumar S, Clergé T, Vijayalakshmi M. Extraction, purification, and biochemical characterization of serine protease from leaves of Abrus precatorius. Prep Biochem Biotechnol. 2017;47:1016-1024 pubmed publisher
    A protease from fresh leaves of Abrus precatorius was purified using two classical chromatography techniques: ion-exchange (DEAE-Sepharose) and Gel filtration (Sephadex G-75)...
  29. Wu S, Fu X, You L, Abbasi A, Meng H, Liu D, et al. Antioxidant, antitumor and immunomodulatory activities of water-soluble polysaccharides in Abrus cantoniensis. Int J Biol Macromol. 2016;89:707-16 pubmed publisher
    b>Abrus cantoniensis is a vegetative food in tropical areas of Asia and claimed as folk beverages and soups consumed for cleansing liver toxicants and preventing liver diseases...
  30. Duracova M, Klimentova J, Fucikova A, Dresler J. Proteomic Methods of Detection and Quantification of Protein Toxins. Toxins (Basel). 2018;10: pubmed publisher
    ..toxins, Clostridium perfringens epsilon toxin, ricin from Ricinus communis, Abrin from Abrus precatorius or control of trade in dual-use items in the European Union, including lesser known protein toxins ..
  31. Yan W, Han Q, Guo P, Wang C, Zhang Z. Simultaneous Detection of Flavonoids, Phenolic Acids and Alkaloids in Abri Herba and Abri Mollis Herba using Liquid Chromatography Tandem Mass Spectrometry. Phytochem Anal. 2016;27:50-6 pubmed publisher
    ..Abri mollis Herba is often used as Abri Herba. Hierarchical cluster analysis (HCA) was applied to compare the similarities and differences of the chemical compositions in the two types of medicinal materials...
  32. Behera B, Mukherjee D, Agarwal T, Das J, Ghosh S, Maiti T. Cell penetrating peptides from agglutinin protein of Abrus precatorius facilitate the uptake of Imatinib mesylate. Colloids Surf B Biointerfaces. 2016;140:169-175 pubmed publisher
    ..two peptides: NH2-SGASDDEEIAR-COOH (SR11) and NH2-ICSSHYEPTVRIGGR-COOH (IR15), derived from the tryptic digest of Abrus precatorius agglutinin. Both IR15 and SR11 were found to be non-toxic at lower doses (up to 50 μg/ml)...
  33. Yadava R, Reddy V. A new biologically active flavonol glycoside from the seeds of Abrus precatorius Linn. J Asian Nat Prod Res. 2002;4:103-7 pubmed
    ..was separated from the chloroform soluble fraction of the concentrated 80% methanolic extract of the seeds of Abrus precatorius (Linn)...
  34. Gul M, Ahmad F, Kondapi A, Qureshi I, Ghazi I. Antioxidant and antiproliferative activities of Abrus precatorius leaf extracts--an in vitro study. BMC Complement Altern Med. 2013;13:53 pubmed publisher
    ..b>Abrus precatorius is a widely distributed tropical medicinal plant with several therapeutic properties...
  35. Gadadhar S, Karande A. Abrin immunotoxin: targeted cytotoxicity and intracellular trafficking pathway. PLoS ONE. 2013;8:e58304 pubmed publisher
    ..The toxin Abrin, isolated from the Abrus precatorius plant, is a type II ribosome inactivating protein, has a catalytic efficiency higher than any other ..
  36. Han Y, Gao S, Xin W, Kang L, Wang J. A recombinant mutant abrin A chain expressed in Escherichia coli can be used as an effective vaccine candidate. Hum Vaccin. 2011;7:838-44 pubmed publisher
    ..This study describes the generation of a substantial amount of mABRA from E. coli and the potential application of mABRA as an effective vaccine candidate for humans, to protect against a high-dose of native abrin...
  37. Ramos M, Sampaio A, Cavada B, Calvete J, Grangeiro T, Debray H. Characterization of the sugar-binding specificity of the toxic lectins isolated from Abrus pulchellus seeds. Glycoconj J. 2001;18:391-400 pubmed
    The sugar-binding specificity of the toxic lectins from Abrus pulchellus seeds was investigated by combination of affinity chromatography of glycopeptides and oligosaccharides of well-defined structures on a lectin-Sepharose column and ..
  38. Okoko I, Osinubi A, Olabiyi O, Kusemiju T, Noronha C, Okanlawon A. Antiovulatory and anti-implantation potential of the methanolic extract of seeds of Abrus precatorius in the rat. Endocr Pract. 2010;16:554-60 pubmed publisher
    To investigate the effect of the methanolic extract of seeds of Abrus precatorius on the estrous cycle, ovulation, and implantation of fetuses in Sprague-Dawley rats.
  39. Silva A, Goto L, Dinarte A, Hansen D, Moreira R, Beltramini L, et al. Pulchellin, a highly toxic type 2 ribosome-inactivating protein from Abrus pulchellus. Cloning heterologous expression of A-chain and structural studies. FEBS J. 2005;272:1201-10 pubmed
    Pulchellin is a type 2 ribosome-inactivating protein isolated from seeds of the Abrus pulchellus tenuiflorus plant...
  40. Garber E, Walker J, O Brien T. Detection of abrin in food using enzyme-linked immunosorbent assay and electrochemiluminescence technologies. J Food Prot. 2008;71:1868-74 pubmed
    Abrin is a toxic ribosome-inactivating protein present in beans of Abrus precatorius, also known as rosary peas...
  41. Subrahmanyan D, Mathew J, Raj M. An unusual manifestation of Abrus precatorius poisoning: a report of two cases. Clin Toxicol (Phila). 2008;46:173-5 pubmed publisher
    b>Abrus precatorius seeds are highly toxic and are often ingested as a means of suicide in India...
  42. Sahoo R, Hamide A, Amalnath S, Narayana B. Acute demyelinating encephalitis due to Abrus precatorius poisoning--complete recovery after steroid therapy. Clin Toxicol (Phila). 2008;46:1071-3 pubmed publisher
    Poisoning from Abrus precatorius is attributed to a toxalbumin (abrin) that acts by inhibiting protein synthesis and rarely can cause immuno-mediated demyelination. We report a case of abrin poisoning with demyelination.
  43. Roy B, Das T, Maiti T, Chakraborty S. Effect of fluidic transport on the reaction kinetics in lectin microarrays. Anal Chim Acta. 2011;701:6-14 pubmed publisher
    ..Here we show, using two standard lectins namely Concanavalin A and Abrus Agglutinin, that the steady state binding efficiency unexpectedly declines beyond a critical shear rate magnitude...
  44. Vaidya A, Raut A, Vaidya R. Abrus precatorius, Gaertin--an ayurvedic potent phytomedicine. J Assoc Physicians India. 2005;53:739-40; author reply 740 pubmed
  45. Wu S, Fu X, BRENNAN M, Brennan C, Chun C. The Effects of Different Purifying Methods on the Chemical Properties, in Vitro Anti-Tumor and Immunomodulatory Activities of Abrus cantoniensis Polysaccharide Fractions. Int J Mol Sci. 2016;17:511 pubmed publisher
    b>Abrus cantoniensis (Hance) is a popular Chinese vegetable consumed as a beverage, soup or folk medicine...
  46. Bagul M, Srinivasa H, Padh H, Rajani M. A rapid densitometric method for simultaneous quantification of gallic acid and ellagic acid in herbal raw materials using HPTLC. J Sep Sci. 2005;28:581-4 pubmed
    ..The above method was used for the quantification of gallic acid and ellagic acid content in seeds of Abrus precatorius Linn., whole plant of Phyllanthus maderaspatensis Linn., and flowers of Nymphaea alba Linn...
  47. Castilho P, Goto L, Roberts L, Araujo A. Isolation and characterization of four type 2 ribosome inactivating pulchellin isoforms from Abrus pulchellus seeds. FEBS J. 2008;275:948-59 pubmed publisher
    b>Abrus pulchellus seeds contain at least seven closely related and highly toxic type 2 ribosome-inactivating pulchellins, each consisting of a toxic A-chain linked to a sugar binding B-chain...
  48. Ramnath V, Kuttan G, Kuttan R. Antitumour effect of abrin on transplanted tumours in mice. Indian J Physiol Pharmacol. 2002;46:69-77 pubmed
    Abrin, a galactose specific lectin was purified using sepharose 4B affinity column from seeds of Abrus precatorius. It exhibited antitumour activity in mice when used at a sublethal dose of 7...
  49. de Matos D, de Ribeiro L, Tansini A, Ferreira L, Placeres M, Colombo L, et al. Immunological response in mice bearing LM3 breast tumor undergoing pulchellin treatment. BMC Complement Altern Med. 2012;12:107 pubmed publisher
    ..Pulchellin, a type 2 RIP, is suggested to induce immune responses that have a role in controlling cancer...
  50. Xiao Z, Wang F, Sun A, Li C, Huang C, Zhang S. A new triterpenoid saponin from Abrus precatorius Linn. Molecules. 2011;17:295-302 pubmed publisher
    ..acid B (4), abruslactone A (5), abrusogenin (6) and abrusoside C (7) were isolated from the leaves and stems of Abrus precatorius. Their structures were elucidated on the basis of physical and NMR analysis, respectively...
  51. Nwodo N, Nwodo O. Antitrypanosomal potentials of the extract and fractions of Abrus precatorius seeds. Asian Pac J Trop Med. 2012;5:857-61 pubmed publisher
    To evaluate the in vivo trypanocidal activity of the methanol extract and fractions of Abrus precatorius seeds in mice. Parasiteamia was induced unto mice by intraperitoneal injection of 1.25×10(5)Trypanosoma in normal saline...
  52. Felder E, Mossbrugger I, Lange M, Wölfel R. Simultaneous detection of ricin and abrin DNA by real-time PCR (qPCR). Toxins (Basel). 2012;4:633-42 pubmed publisher
    ..2 genomes per reaction for abrin DNA. The suitability of the assays was exemplified by detection of ricin and abrin contaminations in a food matrix...
  53. Johnson R, Zhou Y, Jain R, Lemire S, Fox S, Sabourin P, et al. Quantification of L-abrine in human and rat urine: a biomarker for the toxin abrin. J Anal Toxicol. 2009;33:77-84 pubmed
    ..Quantification of L-abrine beyond 24 h is limited by rapid excretion of the biomarker and the level of the L-abrine dose...
  54. Wu J, Wu A, Yang Z, Chen Y, Singha B, Chow L, et al. Recognition intensities of submolecular structures, mammalian glyco-structural units, ligand cluster and polyvalency in abrin-a-carbohydrate interactions. Biochimie. 2010;92:147-56 pubmed publisher
    Abrin-a is the most toxic fraction of lectins isolated from Abrus precatorius seeds and belongs to the family of type 2 ribosome inactivating proteins (RIP)...
  55. Huang R, Yu Y, Hu Y, Sheng X. [Effects of different nitrogenous compounds on growth and nodulation of Abrus cantoniensis]. Zhongguo Zhong Yao Za Zhi. 2005;30:1906-9 pubmed
    The research aimed at the effects of different nitrogenous compounds on growth and nodulation of Abrus cantoniensis.
  56. Kim N, Kim D, Kinghorn A. New triterpenoids from the leaves of Abrus precatorius. Nat Prod Lett. 2002;16:261-6 pubmed
    ..and one known (4) triterpenoid were isolated from an acid hydrolyzed methanol-soluble extract of the leaves of Abrus precatorius...
  57. Ohba H, Moriwaki S, Bakalova R, Yasuda S, Yamasaki N. Plant-derived abrin-a induces apoptosis in cultured leukemic cell lines by different mechanisms. Toxicol Appl Pharmacol. 2004;195:182-93 pubmed
  58. Cheng J, Lu T, Liu C, Lin J. A biophysical elucidation for less toxicity of agglutinin than abrin-a from the seeds of Abrus precatorius in consequence of crystal structure. J Biomed Sci. 2010;17:34 pubmed publisher
    X-ray crystal structure determination of agglutinin from Abrus precatorius in Taiwan is presented...
  59. Pillay V, Bhagyanathan P, Krishnaprasad R, Rajesh R, Vishnupriya N. Poisoning due to white seed variety of Abrus precatorius. J Assoc Physicians India. 2005;53:317-9 pubmed
    We report an unusual case of poisoning involving the white seed variety of Abrus precatorius that caused serious manifestations in a middle-aged male who had consumed the seeds on the advice of a folk medicine practitioner...
  60. Huang J, Zhang W, Li X, Feng S, Ye G, Wei H, et al. Acute abrin poisoning treated with continuous renal replacement therapy and hemoperfusion successfully: A case report. Medicine (Baltimore). 2017;96:e7423 pubmed publisher
    Abrin is a highly toxic protein obtained from the seeds of Abrus precatorius, but poisoning due to ingestion of A precatorius is extremely rare in China.
  61. Sinha N, Panda P, Naik P, Das D, Mukhopadhyay S, Maiti T, et al. Abrus agglutinin promotes irreparable DNA damage by triggering ROS generation followed by ATM-p73 mediated apoptosis in oral squamous cell carcinoma. Mol Carcinog. 2017;56:2400-2413 pubmed publisher
    ..Herein, we evaluated the anticancer efficacy of Abrus agglutinin (AGG), a plant lectin, in oral squamous cell carcinoma...
  62. Huang R, Sheng X, Yu Y. [Isolation and biological characteristics of rhizobia strains from Abrus cantoniensis]. Zhongguo Zhong Yao Za Zhi. 2005;30:971-7 pubmed
    The research aimed at studying the biological characteristics of rhizobia isolated from Abrus cantoniensis.
  63. Huang R, Yu Y, Hu Y, Sheng X. [Determination of total flavonoids in Abrus cantoniensis and its dynamic changes]. Zhongguo Zhong Yao Za Zhi. 2006;31:1428-31 pubmed
    To develop a method for ultrasonic extraction and determination of total flavonoids in Abrus cantoniensis, and to analyze its dynamic changes.
  64. Adedapo A, Omoloye O, Ohore O. Studies on the toxicity of an aqueous extract of the leaves of Abrus precatorius in rats. Onderstepoort J Vet Res. 2007;74:31-6 pubmed
    The toxic effects of an aqueous extract of Abrus precatorius were studied in 20 male white rats over a period of 18 days. The rats were divided into four groups of five rats per group...
  65. Ghosh D, Maiti T. Effects of native and heat-denatured Abrus agglutinin on tumor-associated macrophages in Dalton's lymphoma mice. Immunobiology. 2007;212:667-73 pubmed
    ..Various immunomodulatory compounds could be used to modulate TAMs. In this study we used Abrus agglutinin, a plant lectin, in its native and heat-denatured forms, to investigate its effect on TAMs in Dalton's ..
  66. Zhang Q, Cai H, Mo Z, Shi J, Sun X, Peng Q, et al. [Experimental research on prevention and treatment of fatty liver rats with Abrus cantoniensis]. Zhong Yao Cai. 2012;35:1450-5 pubmed
    To investigate the effects of Abrus cantoniensis (AC) on blood lipid metabolism, pathomorphological change of the liver and fenestrae of liver sinus endothelial cell (LSEC) in fatty liver disease rats.
  67. Singh R, Shelley -. Polysaccharide structure of degraded glucomannan from Abrus precatorius Linn. seeds. J Environ Biol. 2007;28:461-4 pubmed
    Degraded glucomannan was isolated from Abrus precatorius Linn. seed polysaccharide (Papilionaceae)...