phyllanthus

Summary

Summary: A plant genus of the family EUPHORBIACEAE. Bahupatra (MEDICINE, AYURVEDIC) is prepared from this.

Top Publications

  1. Bhattacharjee R, Sil P. The protein fraction of Phyllanthus niruri plays a protective role against acetaminophen induced hepatic disorder via its antioxidant properties. Phytother Res. 2006;20:595-601 pubmed
    The aim of this study was to investigate the hepatoprotective action of the protein fraction of Phyllanthus niruri against acetaminophen (APAP) hepatotoxicity. The partially purified protein fraction of P...
  2. Raphael K, Kuttan R. Inhibition of experimental gastric lesion and inflammation by Phyllanthus amarus extract. J Ethnopharmacol. 2003;87:193-7 pubmed
    Methanolic extract of Phyllanthus amarus Shum & Thonn (Euphorbiaceae) 50, 200, and 1000 mg/kg body weight significantly inhibited gastric lesions, induced by intragastric administration of absolute ethanol (8 ml/kg)...
  3. Barros M, Schor N, Boim M. Effects of an aqueous extract from Phyllantus niruri on calcium oxalate crystallization in vitro. Urol Res. 2003;30:374-9 pubmed
    b>Phyllanthus niruri is a plant used in Brazilian folk medicine for the treatment of urolithiasis. It was previously observed that P...
  4. Khatoon S, Rai V, Rawat A, Mehrotra S. Comparative pharmacognostic studies of three Phyllanthus species. J Ethnopharmacol. 2006;104:79-86 pubmed
    Different species of Phyllanthus are considered to be very effective hepatoprotective agents in the Indian indigenous systems of medicine and are considered bitter, astringent, stomachic, diuretic, febrifuge, deobstruant and antiseptic...
  5. Khanna A, Rizvi F, Chander R. Lipid lowering activity of Phyllanthus niruri in hyperlipemic rats. J Ethnopharmacol. 2002;82:19-22 pubmed
    The lipid lowering activity (LLA) of Phyllanthus niruri has been studied in triton and cholesterol fed hyperlipemic rats. Serum lipids were lowered by P. niruri extract orally fed (250 mg/kg b.w...
  6. Ali H, Houghton P, Soumyanath A. alpha-Amylase inhibitory activity of some Malaysian plants used to treat diabetes; with particular reference to Phyllanthus amarus. J Ethnopharmacol. 2006;107:449-55 pubmed
    ..Inhibitory activity studied by two different protocols (with and without pre-incubation) showed that Phyllanthus amarus hexane extract had alpha-amylase inhibitory properties...
  7. Jain N, Lodhi S, Jain A, Nahata A, Singhai A. Effects of Phyllanthus acidus (L.) Skeels fruit on carbon tetrachloride-induced acute oxidative damage in livers of rats and mice. Zhong Xi Yi Jie He Xue Bao. 2011;9:49-56 pubmed
    The present study was undertaken with a view to validate the traditional use of Phyllanthus acidus (L.) Skeels fruit as a hepatoprotective agent. The 70% ethanolic extract of P. acidus fruit (100, 200 and 400 mg/kg, p.o...
  8. Tuchinda P, Kumkao A, Pohmakotr M, Sophasan S, Santisuk T, Reutrakul V. Cytotoxic arylnaphthalide lignan glycosides from the aerial parts of Phyllanthus taxodiifolius. Planta Med. 2006;72:60-2 pubmed
    ..A methyl ether, together with a triterpene, glochidone, have been isolated from the aerial parts of Phyllanthus taxodiifolius. The structures were established using spectral and chemical methods...
  9. Asha V, Sheeba M, Suresh V, Wills P. Hepatoprotection of Phyllanthus maderaspatensis against experimentally induced liver injury in rats. Fitoterapia. 2007;78:134-41 pubmed
    The hexane extract of Phyllanthus maderaspatensis (200 and 100 mg/kg) showed significant hepatoprotection on carbon tetrachloride and thioacetamide induced liver damage in rats...

More Information

Publications84

  1. Xu M, Zha Z, Qin X, Zhang X, Yang C, Zhang Y. Phenolic antioxidants from the whole plant of Phyllanthus urinaria. Chem Biodivers. 2007;4:2246-52 pubmed
    The 1,1-diphenyl-2-picrydydrazyl (DPPH) assay on the extract of Phyllanthus urinaria L. (Euphorbiaceae) displayed considerable radical-scavenging activity (SC50 = 14.3 microg/ml)...
  2. Surya Narayanan B, Latha P, Rukkumani R. Protective effects of Phyllanthus amarus on fibrotic markers during alcohol and polyunsaturated fatty acid-induced toxicity. Toxicol Mech Methods. 2011;21:48-52 pubmed publisher
    ..The focus of the present study is to analyze the effect of Phyllanthus amarus on MMP and TIMPs activity in alcohol and thermally oxidized polyunsaturated fatty acid (PUFA)-induced ..
  3. Mazumder A, Mahato A, Mazumder R. Antimicrobial potentiality of Phyllanthus amarus against drug resistant pathogens. Nat Prod Res. 2006;20:323-6 pubmed
    The antimicrobial potentiality of the methanolic extract of Phyllanthus amarus (Family: Euphorbiaceae) was studied against some drug resistant pathogenic bacterial strains by disc diffusion and agar dilution method...
  4. Leite D, Kassuya C, Mazzuco T, Silvestre A, de Melo L, Rehder V, et al. The cytotoxic effect and the multidrug resistance reversing action of lignans from Phyllanthus amarus. Planta Med. 2006;72:1353-8 pubmed
    ..evaluated the possible cytotoxic effect and MDR reversing properties of the extract and compounds isolated from Phyllanthus amarus...
  5. Alvarez A, Dalton K, Nicieza I, Diñeiro Y, Picinelli A, Melon S, et al. Bioactivity-guided fractionation of Phyllanthus orbicularis and identification of the principal anti HSV-2 compounds. Phytother Res. 2012;26:1513-20 pubmed publisher
    The antiherpes virus properties of Phyllanthus orbicularis Kunth, a Cuban-endemic medicinal plant, have been reported previously but data on its phytochemical profile and identification of antiviral metabolites as well as their ..
  6. Jain N, Singhai A. Protective effects of Phyllanthus acidus (L.) Skeels leaf extracts on acetaminophen and thioacetamide induced hepatic injuries in Wistar rats. Asian Pac J Trop Med. 2011;4:470-4 pubmed publisher
    To investigate and compare the hepatoprotective effects of crude ethanolic and aqueous extracts of Phyllanthus acidus (L.) Skeels (P. acidus) leaves on acetaminophen (APAP) and thioacetamide (TAA) induced liver toxicity in wistar rats...
  7. Gopi S, Setty O. Protective effect of Phyllanthus fraternus against bromobenzene induced mitochondrial dysfunction in rat liver mitochondria. Food Chem Toxicol. 2010;48:2170-5 pubmed publisher
    The objective of the current study was to investigate the protective effect of an aqueous extract of Phyllanthus fraternus (AEPF) against bromobenzene induced mitochondrial dysfunction in rat liver mitochondria...
  8. Naaz F, Javed S, Abdin M. Hepatoprotective effect of ethanolic extract of Phyllanthus amarus Schum. et Thonn. on aflatoxin B1-induced liver damage in mice. J Ethnopharmacol. 2007;113:503-9 pubmed
    b>Phyllanthus amarus Schum. et Thonn. (Bhuia amla; Euphorbiacae) is a herb common to central and southern India. It is an ayurvedic herb and has a wide range of traditional uses in different diseases...
  9. Dirjomuljono M, Kristyono I, Tjandrawinata R, Nofiarny D. Symptomatic treatment of acute tonsillo-pharyngitis patients with a combination of Nigella sativa and Phyllanthus niruri extract. Int J Clin Pharmacol Ther. 2008;46:295-306 pubmed
    ..NSPN extract containing Nigella sativa and Phyllanthus niruri extracts has both antiinflammatory and immunomodulatory effects...
  10. Huang S, Yang R, Chen M, Pang J. Phyllanthus urinaria induces the Fas receptor/ligand expression and ceramide-mediated apoptosis in HL-60 cells. Life Sci. 2004;75:339-51 pubmed
    b>Phyllanthus urinaria (P. urinaria), a widely used herb medicine, was tested for the anticancer effect on human myeloid leukemia cells in this study. The water extract of P...
  11. Priya K, Yin W, Chan K. Anti-quorum sensing activity of the traditional Chinese herb, Phyllanthus amarus. Sensors (Basel). 2013;13:14558-69 pubmed publisher
    ..In this study, crude extracts of Phyllanthus amarus Schumach...
  12. Singh M, Tiwari N, Shanker K, Verma R, Gupta A, Gupta M. Two new lignans from Phyllanthus amarus. J Asian Nat Prod Res. 2009;11:562-8 pubmed publisher
    ..2), were isolated from the leaves of Phyllanthus amarus and their structures were established by spectral analysis...
  13. Ifeoma O, Samuel O, Itohan A, Adeola S. Isolation, fractionation and evaluation of the antiplasmodial properties of Phyllanthus niruri resident in its chloroform fraction. Asian Pac J Trop Med. 2013;6:169-75 pubmed publisher
    To investigate the antiplasmodial activity of Phyllanthus niruri (P. niruri) methanol extract (ME) and its fractions in mice. P...
  14. Huang S, Yang R, Lee P, Yang S, Liao S, Chen T, et al. Anti-tumor and anti-angiogenic effects of Phyllanthus urinaria in mice bearing Lewis lung carcinoma. Int Immunopharmacol. 2006;6:870-9 pubmed
    b>Phyllanthus urinaria, a widely used herb medicine in Asia, was tested for its anti-tumor effect in vivo for the first time. The anti-tumor activity in P...
  15. Lam W, Leung K, Law P, Lee S, Chan H, Fung K, et al. Antiviral effect of Phyllanthus nanus ethanolic extract against hepatitis B virus (HBV) by expression microarray analysis. J Cell Biochem. 2006;97:795-812 pubmed
    Ethanolic extract of Phyllanthus nanus (P. nanus) treatment exhibited potent antiviral activity against Hepatitis B virus (HBV). The effects of these extracts on HBV in the HBV genome integrated cell lines--Alexander cells and HepG2 2.2...
  16. Huang R, Huang Y, Ou J, Chen C, Hsu F, Chang C. Screening of 25 compounds isolated from Phyllanthus species for anti-human hepatitis B virus in vitro. Phytother Res. 2003;17:449-53 pubmed
    ..of the HBsAg and HBeAg as antiviral indicators, a study was conducted on 25 compounds isolated from four Phyllanthus (Euphorbiaceae) plants, including P. amarus Schum. & Thonn., P. multi florus Willd., P. tenellus Roxb...
  17. Naik A, Juvekar A. Effects of alkaloidal extract of Phyllanthus niruri on HIV replication. Indian J Med Sci. 2003;57:387-93 pubmed
    b>Phyllanthus niruri has been found to exhibit marked inhibitory effect on hepatitis B virus evident by its exhaustive utility in cases of chronic jaundice...
  18. Colombo R, de L Batista A, Teles H, Silva G, Bomfim G, Burgos R, et al. Validated HPLC method for the standardization of Phyllanthus niruri (herb and commercial extracts) using corilagin as a phytochemical marker. Biomed Chromatogr. 2009;23:573-80 pubmed publisher
    b>Phyllanthus niruri L., commonly known in Brazil as 'quebra-pedra', has long been used in the treatment of diverse diseases and especially urolithiasis. The therapeutic effects of P...
  19. Amaechina F, Omogbai E. Hypotensive effect of aqueous extract of the leaves of Phyllanthus amarus Schum and Thonn (Euphorbiaceae). Acta Pol Pharm. 2007;64:547-52 pubmed
    The plant of Phyllanthus amarus is used as diuretic and to lower blood pressure in traditional medicine practice...
  20. Lin S, Wang C, Lu Y, Wu W, Hou W. Antioxidant, anti-semicarbazide-sensitive amine oxidase, and anti-hypertensive activities of geraniin isolated from Phyllanthus urinaria. Food Chem Toxicol. 2008;46:2485-92 pubmed publisher
    The wrinkle-fruited leaf flower (Phyllanthus urinaria L.) (Euphorbiaceae) is widely used as a traditional folk medicine for inflammatory relief...
  21. Lai C, Fang S, Rao Y, Geethangili M, Tang C, Lin Y, et al. Inhibition of Helicobacter pylori-induced inflammation in human gastric epithelial AGS cells by Phyllanthus urinaria extracts. J Ethnopharmacol. 2008;118:522-6 pubmed publisher
    ..This study is aimed at evaluating the antimicrobial activity of Phyllanthus urinaria Linnea (Euphorbiaceae), chloroform (PUC) and methanol (PUM) extracts, and its eight isolates on H...
  22. Kassuya C, Silvestre A, Menezes de Lima O, Marotta D, Rehder V, Calixto J. Antiinflammatory and antiallodynic actions of the lignan niranthin isolated from Phyllanthus amarus. Evidence for interaction with platelet activating factor receptor. Eur J Pharmacol. 2006;546:182-8 pubmed
    Previous studies have shown that the extracts obtained from Phyllanthus amarus, and some of the lignans isolated from it, exhibit pronounced antiinflammatory properties...
  23. Hari Kumar K, Kuttan R. Inhibition of drug metabolizing enzymes (cytochrome P450) in vitro as well as in vivo by Phyllanthus amarus SCHUM & THONN. Biol Pharm Bull. 2006;29:1310-3 pubmed
    An alcoholic extract of Phyllanthus amarus (P. amarus) was found to inhibit cytochrome P450 (P450) enzymes both in vivo as well as in vitro...
  24. Sousa M, Ousingsawat J, Seitz R, Puntheeranurak S, Regalado A, Schmidt A, et al. An extract from the medicinal plant Phyllanthus acidus and its isolated compounds induce airway chloride secretion: A potential treatment for cystic fibrosis. Mol Pharmacol. 2007;71:366-76 pubmed
    ..We examined herbal extracts of the common Thai medicinal euphorbiaceous plant Phyllanthus acidus for their potential effects on epithelial transport...
  25. Ravikumar Y, Ray U, Nandhitha M, Perween A, Raja Naika H, Khanna N, et al. Inhibition of hepatitis C virus replication by herbal extract: Phyllanthus amarus as potent natural source. Virus Res. 2011;158:89-97 pubmed publisher
    ..Effect on viral RNA replication was investigated by using TaqMan Real time RT-PCR. Interestingly, Phyllanthus amarus root (PAR) extract showed significant inhibition of HCV-NS3 protease enzyme; whereas P...
  26. Ramasamy S, Abdul Wahab N, Zainal Abidin N, Manickam S, Zakaria Z. Growth inhibition of human gynecologic and colon cancer cells by Phyllanthus watsonii through apoptosis induction. PLoS ONE. 2012;7:e34793 pubmed publisher
    b>Phyllanthus watsonii Airy Shaw is an endemic plant found in Peninsular Malaysia. Although there are numerous reports on the anti cancer properties of other Phyllanthus species, published information on the cytotoxicity of P...
  27. Kassuya C, Silvestre A, Rehder V, Calixto J. Anti-allodynic and anti-oedematogenic properties of the extract and lignans from Phyllanthus amarus in models of persistent inflammatory and neuropathic pain. Eur J Pharmacol. 2003;478:145-53 pubmed
    ..the hexanic extract, lignan-rich fraction and purified lignans from a plant used in the traditional medicine, Phyllanthus amarus, in the inflammatory and neuropathic models of nociception...
  28. Saleem M, Nazir M, Akhtar N, Onocha P, Riaz N, Jabbar A, et al. New phthalates from Phyllanthus muellerianus (Euphorbiaceae). J Asian Nat Prod Res. 2009;11:974-7 pubmed publisher
    Species of the genus Phyllanthus are known for their medicinal values and many are explored phytochemically. Some of them produce phthalates which usually have antimicrobial properties...
  29. Chularojmontri L, Ihara Y, Muroi E, Goto S, Kondo T, Wattanapitayakul S. Cytoprotective role of Phyllanthus urinaria L. and glutathione-S transferase Pi in doxorubicin-induced toxicity in H9c2 cells. J Med Assoc Thai. 2009;92 Suppl 3:S43-51 pubmed
    To examine cytoprotective effect of Phyllanthus urinaria (PU) ethanolic extract in doxorubicin (DOX)-induced toxicity...
  30. Rajkapoor B, Sankari M, Sumithra M, Anbu J, Harikrishnan N, Gobinath M, et al. Antitumor and cytotoxic effects of Phyllanthus polyphyllus on Ehrlich ascites carcinoma and human cancer cell lines. Biosci Biotechnol Biochem. 2007;71:2177-83 pubmed
    To evaluate the antitumor and cytotoxic activity of methanol extract of Phyllanthus polyphyllus (MPP) in mice and human cancer cell lines, the antitumor activity of MPP was evaluated against an Ehrlich ascites carcinoma (EAC) tumor model...
  31. Shabeer J, Srivastava R, Singh S. Antidiabetic and antioxidant effect of various fractions of Phyllanthus simplex in alloxan diabetic rats. J Ethnopharmacol. 2009;124:34-8 pubmed publisher
    To evaluate the antidiabetic and antioxidant effects of various fractions of Phyllanthus simplex on alloxan induced diabetes in rats.
  32. Ahmed B, al Howiriny T, Mathew R. Antihepatotoxic activity of Phyllanthus fraternus. Pharmazie. 2002;57:855-6 pubmed
    Different fractions of alcoholic extracts of aerial parts and roots of Phyllanthus fraternus Webster (Euphorbiaceae) were screened for antihepatotoxic activity on carbon tetrachloride induced liver damage in albino rats...
  33. Vernhes M, González Pumariega M, Andrade L, Schuch A, de Lima Bessa K, Menck C, et al. Protective effect of a Phyllanthus orbicularis aqueous extract against UVB light in human cells. Pharm Biol. 2013;51:1-7 pubmed publisher
    ..b>Phyllanthus orbicularis Kunth (Euphorbiaceae) is a Cuban endemic plant used in popular medicine...
  34. Harikumar K, Kuttan G, Kuttan R. Phyllanthus amarus inhibits cell growth and induces apoptosis in Dalton's lymphoma ascites cells through activation of caspase-3 and downregulation of Bcl-2. Integr Cancer Ther. 2009;8:190-4 pubmed publisher
    The authors found in an earlier study that Phyllanthus amarus extract could significantly inhibit the solid and ascites tumor development in mice induced by Dalton's lymphoma ascites (DLA) cells...
  35. Zhang L, Guo Y, Tu G, Guo W, Miao F. Isolation and identification of a novel ellagitannin from Phyllanthus urinaria L. Yao Xue Xue Bao. 2004;39:119-22 pubmed
    To investigate the chemical constituents of Phyllanthus urinaria L.
  36. Tuchinda P, Kornsakulkarn J, Pohmakotr M, Kongsaeree P, Prabpai S, Yoosook C, et al. Dichapetalin-type triterpenoids and lignans from the aerial parts of Phyllanthus acutissima. J Nat Prod. 2008;71:655-63 pubmed publisher
    Chemical investigation of the aerial parts of Phyllanthus acutissima resulted in the isolation of five new dichapetalin-type triterpenoids, acutissimatriterpenes A-E ( 1- 5), and two new lignans, acutissimalignans A ( 6) and B ( 7), ..
  37. Srirama R, Senthilkumar U, Sreejayan N, Ravikanth G, Gurumurthy B, Shivanna M, et al. Assessing species admixtures in raw drug trade of Phyllanthus, a hepato-protective plant using molecular tools. J Ethnopharmacol. 2010;130:208-15 pubmed publisher
    b>Phyllanthus (Euphorbiaceae) species are well known for their hepato-protective activity and are used in several ethno-medicines in indigenous health care systems in India.
  38. Pruesapan K, Telford I, Bruhl J, Draisma S, Van Welzen P. Delimitation of Sauropus (Phyllanthaceae) based on plastid matK and nuclear ribosomal ITS DNA Sequence data. Ann Bot. 2008;102:1007-18 pubmed publisher
    A recent molecular phylogenetic study showed that Sauropus is deeply embedded within Phyllanthus together with its allies, Breynia and Glochidion...
  39. Harikumar K, Kuttan R. An extract of Phyllanthus amarus protects mouse chromosomes and intestine from radiation induced damages. J Radiat Res. 2007;48:469-76 pubmed
    We reported earlier on our preliminary study of the radioprotective effect of Phyllanthus amarus (P.amarus) in mice. P.amarus was found to inhibit the myelosuppression and elevated the levels of antioxidant enzymes in the blood and liver...
  40. Pramyothin P, Ngamtin C, Poungshompoo S, Chaichantipyuth C. Hepatoprotective activity of Phyllanthus amarus Schum. et. Thonn. extract in ethanol treated rats: in vitro and in vivo studies. J Ethnopharmacol. 2007;114:169-73 pubmed
    ..study was undertaken to investigate the protective effect and possible mechanism of aqueous extract from Phyllanthus amarus Schum. et. Thonn. (PA) on ethanol-induced rat hepatic injury...
  41. Rai V, Mehrotra S. Chromium-induced changes in ultramorphology and secondary metabolites of Phyllanthus amarus Schum & Thonn. - an hepatoprotective plant. Environ Monit Assess. 2008;147:307-15 pubmed publisher
    ..In this context attempts have been made to see the effect of Cr on a very important medicinal plant Phyllanthus amarus Schum and Thonn. It has focused as a hepatoprotective plant curing hepatitis 'B' in modern research...
  42. Barros M, Lima R, Mercuri L, Matos J, Schor N, Boim M. Effect of extract of Phyllanthus niruri on crystal deposition in experimental urolithiasis. Urol Res. 2006;34:351-7 pubmed
    b>Phyllanthus niruri (Pn) is a plant that has been shown to interfere in the growth and aggregation of calcium oxalate (CaOx) crystals...
  43. Chularojmontri L, Wattanapitayakul S, Herunsalee A, Charuchongkolwongse S, Niumsakul S, Srichairat S. Antioxidative and cardioprotective effects of Phyllanthus urinaria L. on doxorubicin-induced cardiotoxicity. Biol Pharm Bull. 2005;28:1165-71 pubmed
    ..In this study, we investigated the antioxidative and cytoprotective effects of Phyllanthus urinaria (PU) against DOX toxicity using H9c2 cardiac myoblasts...
  44. Fang S, Rao Y, Tzeng Y. Anti-oxidant and inflammatory mediator's growth inhibitory effects of compounds isolated from Phyllanthus urinaria. J Ethnopharmacol. 2008;116:333-40 pubmed publisher
    b>Phyllanthus urinaria Linnea (Euphorbiaceae), is a traditional anti-hepatitis herb used in Taiwan...
  45. Subeki S, Matsuura H, Takahashi K, Yamasaki M, Yamato O, Maede Y, et al. Anti-babesial and anti-plasmodial compounds from Phyllanthus niruri. J Nat Prod. 2005;68:537-9 pubmed
    Bioassay-guided fractionation of boiled aqueous extracts from the whole plant of Phyllanthus niruri led to the isolation of 1-O-galloyl-6-O-luteoyl-alpha-d-glucose (1), with IC(50) values of 4.7 microg/mL against Babesia gibsoni and 1...
  46. Gowrishankar R, Kumar M, Menon V, Divi S, Saravanan M, Magudapathy P, et al. Trace Element Studies on Tinospora cordifolia (Menispermaceae), Ocimum sanctum (Lamiaceae), Moringa oleifera (Moringaceae), and Phyllanthus niruri (Euphorbiaceae) Using PIXE. Biol Trace Elem Res. 2010;133:357-63 pubmed publisher
    ..F. & Thomson (Menispermaceae), Ocimum sanctum L. (Lamiaceae), Moringa oleifera Lam. (Moringaceae), and Phyllanthus niruri L...
  47. Iizuka T, Moriyama H, Nagai M. Vasorelaxant effects of methyl brevifolincarboxylate from the leaves of Phyllanthus niruri. Biol Pharm Bull. 2006;29:177-9 pubmed
    Methyl brevifolincarboxylate (1) isolated from the leaves of Phyllanthus niruri L. showed a vasorelaxant effect on rat aortic rings...
  48. Ratnayake R, Covell D, Ransom T, Gustafson K, Beutler J. Englerin A, a selective inhibitor of renal cancer cell growth, from Phyllanthus engleri. Org Lett. 2009;11:57-60 pubmed publisher
    An extract from Phyllanthus engleri was identified in a bioinformatic analysis of NCI 60-cell natural product extract screening data that selectively inhibited the growth of renal cancer cell lines...
  49. Chang C, Lien Y, Liu K, Lee S. Lignans from Phyllanthus urinaria. Phytochemistry. 2003;63:825-33 pubmed
    Chemical investigation on the aerial and the root parts of Phyllanthus urinaria L. culminated in the isolation of four lignans, namely 5-demethoxyniranthin, urinatetralin, dextrobursehernin, urinaligran, together with nine known lignans...
  50. Poompachee K, Chudapongse N. Comparison of the antioxidant and cytotoxic activities of Phyllanthus virgatus and Phyllanthus amarus extracts. Med Princ Pract. 2012;21:24-9 pubmed publisher
    To determine the antioxidant activity and cytotoxicity of Phyllanthus virgatus crude extract compared to Phyllanthus amarus.
  51. Chouhan H, Singh S. Phytochemical analysis, antioxidant and anti-inflammatory activities of Phyllanthus simplex. J Ethnopharmacol. 2011;137:1337-44 pubmed publisher
    b>Phyllanthus simplex (Family: Euphorbiacae) is widely used in traditional medicines for treatment of various diseases including inflammation.
  52. Huang S, Yang R, Yang L, Lee P, Pang J. Phyllanthus urinaria triggers the apoptosis and Bcl-2 down-regulation in Lewis lung carcinoma cells. Life Sci. 2003;72:1705-16 pubmed
    b>Phyllanthus urinaria (P. urinaria), a widely used herb medicine, was tested for the anticancer effect in its water extract for the first time. The water extract of P...
  53. Harikumar K, Kuttan G, Kuttan R. Inhibition of viral carcinogenesis by Phyllanthus amarus. Integr Cancer Ther. 2009;8:254-60 pubmed publisher
    ..In the present study, the authors have evaluated the potential of an extract of Phyllanthus amarus against FMuLv-induced erythroleukemia in BALB/c mice...
  54. Moreira J, Klein Júnior L, Cechinel Filho V, de Campos Buzzi F. Anti-hyperalgesic activity of corilagin, a tannin isolated from Phyllanthus niruri L. (Euphorbiaceae). J Ethnopharmacol. 2013;146:318-23 pubmed publisher
    Corilagin (?-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-D-glucose) is a tannin isolated from Phyllanthus niruri (Euphorbiaceae)...
  55. Krithika R, Verma R. Mitigation of carbon tetrachloride-induced damage by Phyllanthus amarus in liver of mice. Acta Pol Pharm. 2009;66:439-44 pubmed
    ..The aim of the present study was to determine the hepatoprotective activity of Phyllanthus amarus plant extract against carbon tetrachloride (CCl4-induced liver damage in female mice...
  56. Huang S, Yang R, Pang J. Aqueous extract of Phyllanthus urinaria induces apoptosis in human cancer cells. Am J Chin Med. 2004;32:175-83 pubmed
    ..The anticancer effect of aqueous extract prepared from Phyllanthus urinaria (P. urinaria) was investigated by analyzing its potential to induce apoptosis in human cancer cells...
  57. Murugaiyah V, Chan K. Mechanisms of antihyperuricemic effect of Phyllanthus niruri and its lignan constituents. J Ethnopharmacol. 2009;124:233-9 pubmed publisher
    b>Phyllanthus niruri Linn. (Euphorbiaceae) is used as folk medicine in South America to treat excess uric acid...
  58. Micali S, Sighinolfi M, Celia A, De Stefani S, Grande M, Cicero A, et al. Can Phyllanthus niruri affect the efficacy of extracorporeal shock wave lithotripsy for renal stones? A randomized, prospective, long-term study. J Urol. 2006;176:1020-2 pubmed
    b>Phyllanthus niruri is a plant used in Brazilian folk medicine for the treatment of urolithiasis. We assessed the efficacy of P. niruri after extracorporeal shock wave lithotripsy for renal stones.
  59. Parmar J, Verma P, Sharma P, Goyal P. Anti-tumor activity of Phyllanthus niruri (a medicinal plant) on chemical-induced skin carcinogenesis in mice. Asian Pac J Cancer Prev. 2009;10:1089-94 pubmed
    ..Thus, there is a need for exploring drugs/agents which act as chemopreventive agents. Phyllanthus niruri is a well known medicinal plant which has been used in Ayurvedic medicine as hepatoprotective, antiviral,..
  60. Kassuya C, Leite D, de Melo L, Rehder V, Calixto J. Anti-inflammatory properties of extracts, fractions and lignans isolated from Phyllanthus amarus. Planta Med. 2005;71:721-6 pubmed
    This study assessed the anti-inflammatory effect of the extracts and purified lignans obtained from Phyllanthus amarus...
  61. Yadav N, Pal A, Shanker K, Bawankule D, Gupta A, Darokar M, et al. Synergistic effect of silymarin and standardized extract of Phyllanthus amarus against CCl4-induced hepatotoxicity in Rattus norvegicus. Phytomedicine. 2008;15:1053-61 pubmed publisher
    ..of the effective and standardized hepatoprotective combination therapy, silymarin and standardized extract of Phyllanthus amarus has been evaluated against CCl(4)-induced hepatotoxicity in rats. Eight groups of rats were used...
  62. Asare G, Bugyei K, Sittie A, Yahaya E, Gyan B, Adjei S, et al. Genotoxicity, cytotoxicity and toxicological evaluation of whole plant extracts of the medicinal plant Phyllanthus niruri (Phyllanthaceae). Genet Mol Res. 2012;11:100-11 pubmed publisher
    b>Phyllanthus niruri is a medicinal plant (commonly known as stone breaker) found in the tropics and other parts of the world...
  63. Mahdi E, Noor A, Sakeena M, Abdullah G, Abdulkarim M, Sattar M. Formulation and in vitro release evaluation of newly synthesized palm kernel oil esters-based nanoemulsion delivery system for 30% ethanolic dried extract derived from local Phyllanthus urinaria for skin antiaging. Int J Nanomedicine. 2011;6:2499-512 pubmed publisher
    ..The aim of this research was to develop a nanoemulsion cream for topical delivery of 30% ethanolic extract derived from local Phyllanthus urinaria (P. urinaria) for skin antiaging.
  64. Tang Y, Jaganath I, Sekaran S. Phyllanthus spp. induces selective growth inhibition of PC-3 and MeWo human cancer cells through modulation of cell cycle and induction of apoptosis. PLoS ONE. 2010;5:e12644 pubmed publisher
    b>Phyllanthus is a traditional medicinal plant that has been used in the treatment of many diseases including hepatitis and diabetes...
  65. Ramasamy S, Abdul Wahab N, Zainal Abidin N, Manickam S. Effect of extracts from Phyllanthus watsonii Airy Shaw on cell apoptosis in cultured human breast cancer MCF-7 cells. Exp Toxicol Pathol. 2013;65:341-9 pubmed publisher
    Species of Phyllanthus have traditionally been used for hundreds of years for treating many ailments including diabetes, anemia, bronchitis and hepatitis...
  66. Devi V, Shanbhag T, Bairy K, Rao N, Shenoy S. Effect of Phyllanthus niruri on wound healing in rats. Indian J Physiol Pharmacol. 2005;49:487-90 pubmed
  67. Lee S, Jaganath I, Wang S, Sekaran S. Antimetastatic effects of Phyllanthus on human lung (A549) and breast (MCF-7) cancer cell lines. PLoS ONE. 2011;6:e20994 pubmed publisher
    ..Therefore, the purpose of this study was to evaluate the antimetastatic potential of Phyllanthus (P. niruri, P. urinaria, P. watsonii, and P. amarus) on lung and breast carcinoma cells.
  68. Brusotti G, Cesari I, Frassà G, Grisoli P, Dacarro C, Caccialanza G. Antimicrobial properties of stem bark extracts from Phyllanthus muellerianus (Kuntze) Excell. J Ethnopharmacol. 2011;135:797-800 pubmed publisher
    The plants of the genus Phyllanthus (Euphorbiaceae) are widely distributed in most tropical and subtropical countries, and have long been used in folk medicine to treat several diseases...
  69. Manissorn J, Sukrong S, Ruangrungsi N, Mizukami H. Molecular phylogenetic analysis of Phyllanthus species in Thailand and the application of polymerase chain reaction-restriction fragment length polymorphism for Phyllanthus amarus identification. Biol Pharm Bull. 2010;33:1723-7 pubmed
    The genus Phyllanthus (Phyllanthaceae) is distributed in tropical and subtropical regions, and its members are widely used as medicinal plants in many countries...
  70. Dnyaneshwar W, Preeti C, Kalpana J, Bhushan P. Development and application of RAPD-SCAR marker for identification of Phyllanthus emblica LINN. Biol Pharm Bull. 2006;29:2313-6 pubmed
    ..The present study was carried out to develop DNA based marker for identification of Phyllanthus emblica LINN. A putative marker (1.1 kb) specific for P...
  71. Yang C, Cheng H, Lin T, Chiang L, Lin C. Acetone, ethanol and methanol extracts of Phyllanthus urinaria inhibit HSV-2 infection in vitro. Antiviral Res. 2005;67:24-30 pubmed
    b>Phyllanthus urinaria Linnea (Euphorbiaceae) is one of the traditional medicinal plants that are widely applied by oriental people, especially by Chinese and Indian, to ameliorate various kinds of ailments...
  72. Hau D, Gambari R, Wong R, Yuen M, Cheng G, Tong C, et al. Phyllanthus urinaria extract attenuates acetaminophen induced hepatotoxicity: involvement of cytochrome P450 CYP2E1. Phytomedicine. 2009;16:751-60 pubmed publisher
    ..administered intraperitoneally with a lethal dose of acetaminophen, when followed by oral administration of Phyllanthus urinaria extract, may be prevented from death...
  73. Yang C, Cheng H, Lin T, Chiang L, Lin C. Hippomanin A from acetone extract of Phyllanthus urinaria inhibited HSV-2 but not HSV-1 infection in vitro. Phytother Res. 2007;21:1182-6 pubmed
    b>Phyllanthus urinaria Linnea (Euphorbiaceae) is a commonly used traditional medicinal plant in oriental countries and has been reported to possess various biological activities...
  74. Bhattacharyya S, Pal P, Sil P. A 35 kD Phyllanthus niruri protein modulates iron mediated oxidative impairment to hepatocytes via the inhibition of ERKs, p38 MAPKs and activation of PI3k/Akt pathway. Food Chem Toxicol. 2013;56:119-30 pubmed publisher
    It has been reported that the herb, Phyllanthus niruri, possess antioxidant, anti-infection, anti-asthmatic, anti-diuretic, anti-soresis and many more beneficial activities...
  75. Wada S, Iida A, Tanaka R. Screening of triterpenoids isolated from Phyllanthus flexuosus for DNA topoisomerase inhibitory activity. J Nat Prod. 2001;64:1545-7 pubmed
    ..Naturally occurring lupane- and oleanane-type triterpenoids isolated from the bark of Phyllanthus flexuosus were screened for human Topos I and II inhibitory activities...