manihot

Summary

Summary: A plant genus of the family EUPHORBIACEAE that is perennial with conspicuous, almost palmate leaves like those of RICINUS but more deeply parted into five to nine lobes. It is a source of a starch after removal of the cyanogenic glucosides. The common name of Arrowroot is also used with Maranta (MARANTACEAE). The common name of yuca is also used for YUCCA.

Top Publications

  1. Yang J, An D, Zhang P. Expression profiling of cassava storage roots reveals an active process of glycolysis/gluconeogenesis. J Integr Plant Biol. 2011;53:193-211 pubmed publisher
    ..These studies should facilitate our understanding of the storage root formation and cassava improvement. ..
  2. Tiendrébéogo F, Lefeuvre P, Hoareau M, Harimalala M, De Bruyn A, Villemot J, et al. Evolution of African cassava mosaic virus by recombination between bipartite and monopartite begomoviruses. Virol J. 2012;9:67 pubmed publisher
    ..This is the first report of an ACMV-like recombinant begomovirus arisen by interspecific recombination between bipartite and monopartite African begomoviruses. ..
  3. Sojikul P, Kongsawadworakul P, Viboonjun U, Thaiprasit J, Intawong B, Narangajavana J, et al. AFLP-based transcript profiling for cassava genome-wide expression analysis in the onset of storage root formation. Physiol Plant. 2010;140:189-98 pubmed publisher
    Cassava (Manihot esculenta Crantz) is a root crop that accumulates large quantities of starch, and it is an important source of carbohydrate...
  4. Chabwine J, Masheka C, Balol ebwami Z, Maheshe B, Balegamire S, Rutega B, et al. Appearance of konzo in South-Kivu, a wartorn area in the Democratic Republic of Congo. Food Chem Toxicol. 2011;49:644-9 pubmed publisher
    ..Contributory factors included the introduction of new varieties of (bitter) cassava, but konzo may actually be caused by a combination of factors that are yet to be understood...
  5. Carabalí A, Belloti A, Montoya Lerma J. Biological parameters of Bemisia tabaci (Gennadius) biotype B (Hemiptera: Aleyrodidae) on Jatropha gossypiifolia, commercial (Manihot esculenta) and wild cassava (Manihot flabellifolia and M. carthaginensis) (Euphorbiaceae). Neotrop Entomol. 2010;39:562-7 pubmed
    ..hosts in the adaptation process may lead to the establishment of biotype B on commercial varieties of Manihot esculenta. In here, we evaluated Jatropha gossypiifolia, two wild species of cassava (Manihot flabellifolia and M...
  6. Monde G, Walangululu J, Winter S, Bragard C. Dual infection by cassava begomoviruses in two leguminous species (Fabaceae) in Yangambi, Northeastern Democratic Republic of Congo. Arch Virol. 2010;155:1865-9 pubmed publisher
    ..This study shows that whiteflies may transmit CMBs to non-cassava plants under high epidemic pressure...
  7. Duffy S, Holmes E. Validation of high rates of nucleotide substitution in geminiviruses: phylogenetic evidence from East African cassava mosaic viruses. J Gen Virol. 2009;90:1539-47 pubmed publisher
    ..We also validated our rate estimates by comparing them with those depicting the emergence of TYLCV in North America. These results further support the notion that geminiviruses evolve as rapidly as many RNA viruses...
  8. Cliff J, Muquingue H, Nhassico D, Nzwalo H, Bradbury J. Konzo and continuing cyanide intoxication from cassava in Mozambique. Food Chem Toxicol. 2011;49:631-5 pubmed publisher
    ..Attention should be given to the wider question of agricultural development and food security in the regions of Africa where dependence on bitter cassava results in chronic cyanide intoxication and persistent and emerging konzo. ..
  9. Raji A, Anderson J, Kolade O, Ugwu C, Dixon A, Ingelbrecht I. Gene-based microsatellites for cassava (Manihot esculenta Crantz): prevalence, polymorphisms, and cross-taxa utility. BMC Plant Biol. 2009;9:118 pubmed publisher
    Cassava (Manihot esculenta Crantz), a starchy root crop grown in tropical and subtropical climates, is the sixth most important crop in the world after wheat, rice, maize, potato and barley...

More Information

Publications63

  1. Quintero A, Pérez Quintero A, Lopez C. Identification of ta-siRNAs and cis-nat-siRNAs in cassava and their roles in response to cassava bacterial blight. Genomics Proteomics Bioinformatics. 2013;11:172-81 pubmed publisher
    ..This work represents a significant step toward understanding the roles of sRNAs in the immune response of cassava. ..
  2. Vanderschuren H, Alder A, Zhang P, Gruissem W. Dose-dependent RNAi-mediated geminivirus resistance in the tropical root crop cassava. Plant Mol Biol. 2009;70:265-72 pubmed publisher
    ..The method is scalable to stacking by targeting multiple virus isolates with additional hairpins...
  3. An D, Yang J, Zhang P. Transcriptome profiling of low temperature-treated cassava apical shoots showed dynamic responses of tropical plant to cold stress. BMC Genomics. 2012;13:64 pubmed publisher
    ..The development of microarray technology has accelerated the study of global transcription profiling under certain conditions...
  4. Miles D, Jansson E, Mai M, Azer M, Day P, Shadbolt C, et al. A survey of total hydrocyanic acid content in ready-to-eat cassava-based chips obtained in the Australian market in 2008. J Food Prot. 2011;74:980-5 pubmed publisher
    Cassava (Manihot esculenta Crantz) is a widely consumed food in the tropics that naturally contains cyanogenic glycosides (cyanogens, mainly composed of linamarin, acetone cyanohydrin, and hydrocyanic acid)...
  5. Mbanzibwa D, Tian Y, Tugume A, Patil B, Yadav J, Bagewadi B, et al. Evolution of cassava brown streak disease-associated viruses. J Gen Virol. 2011;92:974-87 pubmed publisher
  6. Marie Magdeleine C, Udino L, Philibert L, Bocage B, Archimede H. In vitro effects of Cassava (Manihot esculenta) leaf extracts on four development stages of Haemonchus contortus. Vet Parasitol. 2010;173:85-92 pubmed publisher
    Three extracts (aqueous, methanolic and dichloromethane) of Manihot esculenta (Cassava) leaf were tested in vitro on four development stages of Haemonchus contortus using egg hatch assay (EHA), larval development assay (LDA), L3 ..
  7. Papong S, Malakul P. Life-cycle energy and environmental analysis of bioethanol production from cassava in Thailand. Bioresour Technol. 2010;101 Suppl 1:S112-8 pubmed publisher
    ..It is suggested that a partial substitution of coal with biogas produced from existing wastewater treatment could lead to a significant reduction in the environmental impact...
  8. Thang V, Kanda K, Kobayashi G. Production of acetone-butanol-ethanol (ABE) in direct fermentation of cassava by Clostridium saccharoperbutylacetonicum N1-4. Appl Biochem Biotechnol. 2010;161:157-70 pubmed publisher
    ..9 and 15.5 g/L, respectively. Solvent yield and butanol yield (based on potential glucose) was 0.33 and 0.41, respectively, for fermentation of cassava starch and 0.30 and 0.38, respectively for fermentation using cassava chips...
  9. Gleadow R, Evans J, McCaffery S, Cavagnaro T. Growth and nutritive value of cassava (Manihot esculenta Cranz.) are reduced when grown in elevated CO. Plant Biol (Stuttg). 2009;11 Suppl 1:76-82 pubmed publisher
    ..Here, we examined the direct effect of atmospheric CO(2) on cassava (Manihot esculenta Cranz., manioc), a staple for 750 million people worldwide...
  10. Patil B, Fauquet C. Differential interaction between cassava mosaic geminiviruses and geminivirus satellites. J Gen Virol. 2010;91:1871-82 pubmed publisher
    ..These results call for more detailed analyses of these subviral components and an investigation of their possible interaction with the cassava mosaic disease complex...
  11. Welsch R, Arango J, B r C, Salazar B, Al Babili S, Beltr n J, et al. Provitamin A accumulation in cassava (Manihot esculenta) roots driven by a single nucleotide polymorphism in a phytoene synthase gene. Plant Cell. 2010;22:3348-56 pubmed publisher
    Cassava (Manihot esculenta) is an important staple crop, especially in the arid tropics...
  12. Thakkar S, Huo T, Maziya Dixon B, Failla M. Impact of style of processing on retention and bioaccessibility of beta-carotene in cassava (Manihot esculanta, Crantz). J Agric Food Chem. 2009;57:1344-8 pubmed publisher
  13. Patanun O, Lertpanyasampatha M, Sojikul P, Viboonjun U, Narangajavana J. Computational identification of microRNAs and their targets in cassava (Manihot esculenta Crantz.). Mol Biotechnol. 2013;53:257-69 pubmed publisher
  14. Mbanzibwa D, Tian Y, Tugume A, Mukasa S, Tairo F, Kyamanywa S, et al. Genetically distinct strains of Cassava brown streak virus in the Lake Victoria basin and the Indian Ocean coastal area of East Africa. Arch Virol. 2009;154:353-9 pubmed publisher
    ..Hence, two genetically different and geographically separated populations of CSBV exist in East Africa...
  15. Rabbi I, Kulembeka H, Masumba E, Marri P, Ferguson M. An EST-derived SNP and SSR genetic linkage map of cassava (Manihot esculenta Crantz). Theor Appl Genet. 2012;125:329-42 pubmed publisher
    Cassava (Manihot esculenta Crantz) is one of the most important food security crops in the tropics and increasingly being adopted for agro-industrial processing...
  16. Gomes S, Torres A, Godoy R, Pacheco S, Carvalho J, Nutti M. Effects of boiling and frying on the bioaccessibility of beta-carotene in yellow-fleshed cassava roots (Manihot esculenta Crantz cv. BRS Jari). Food Nutr Bull. 2013;34:65-74 pubmed
    ..The effects of boiling and frying on the bioaccessibility of all-trans-beta-carotene in biofortified BRS Jari cassava roots have not been investigated, although these are conventional methods of cassava preparation...
  17. Patil B, Fauquet C. Cassava mosaic geminiviruses: actual knowledge and perspectives. Mol Plant Pathol. 2009;10:685-701 pubmed publisher
  18. Onzo A, Sabelis M, Hanna R. Effects of ultraviolet radiation on predatory mites and the role of refuges in plant structures. Environ Entomol. 2010;39:695-701 pubmed publisher
    ..This might explain why T. aripo moves out of the apex to forage on leaves only during the night...
  19. Ciglenecki I, Eyema R, Kabanda C, Taafo F, Mekaoui H, Urbaniak V. Konzo outbreak among refugees from Central African Republic in Eastern region, Cameroon. Food Chem Toxicol. 2011;49:579-82 pubmed publisher
    ..Eastern Cameroon is an area with konzo. More effort needs to be put into preventive and educational measures. In addition, timely balanced food rations have to be provided to refugees...
  20. Adeleke M, Popoola S, Agbaje W, Adewale B, Adeoye M, Jimoh W. Larvicidal efficacy of seed oils of Pterocarpus santalinoides and tropical Manihot species against Aedes aegypti and effects on aquatic fauna. Tanzan J Health Res. 2009;11:250-2 pubmed
    ..The larvicidal potentials of the seed oils of Pterocarpus santalinoides and Tropical Manihot species (TMS 30572) were investigated in the laboratory against larvae of Aedes aegypti...
  21. Niklaus M, Gruissem W, Vanderschuren H. Efficient transformation and regeneration of transgenic cassava using the neomycin phosphotransferase gene as aminoglycoside resistance marker gene. GM Crops. 2011;2:193-200 pubmed publisher
  22. Stephenson K, Amthor R, Mallowa S, Nungo R, Maziya Dixon B, Gichuki S, et al. Consuming cassava as a staple food places children 2-5 years old at risk for inadequate protein intake, an observational study in Kenya and Nigeria. Nutr J. 2010;9:9 pubmed publisher
    ..This study tested the hypothesis that Nigerian and Kenyan children consuming cassava as their staple food are at greater risk for inadequate dietary protein intake than those children who consume less cassava...
  23. Patil B, Ogwok E, Wagaba H, Mohammed I, Yadav J, Bagewadi B, et al. RNAi-mediated resistance to diverse isolates belonging to two virus species involved in Cassava brown streak disease. Mol Plant Pathol. 2011;12:31-41 pubmed publisher
    Cassava brown streak disease (CBSD) is emerging as one of the most important viral diseases of cassava (Manihot esculenta) and is considered today as the biggest threat to cassava cultivation in East Africa...
  24. Nitayavardhana S, Shrestha P, Rasmussen M, Lamsal B, van Leeuwen J, Khanal S. Ultrasound improved ethanol fermentation from cassava chips in cassava-based ethanol plants. Bioresour Technol. 2010;101:2741-7 pubmed publisher
    ..Integration of ultrasound application in cassava-based ethanol plants can significantly improve ethanol yields and reduce the overall production costs...
  25. Gu Y, Hu S, Chen J, Shao L, He H, Yang Y, et al. Ammonium acetate enhances solvent production by Clostridium acetobutylicum EA 2018 using cassava as a fermentation medium. J Ind Microbiol Biotechnol. 2009;36:1225-32 pubmed publisher
    ..acetobutylicum EA 2018 were enhanced by the addition of ammonium acetate to the cassava medium...
  26. Dufour D. Assessing diet in populations at risk for konzo and neurolathyrism. Food Chem Toxicol. 2011;49:655-61 pubmed publisher
    ..Biomarkers for assessing the cyanogen exposure from cassava-based diets are available; biomarkers for the ?-ODAP exposure from grass pea diets need development...
  27. Nunn P, Lyddiard J, Christopher Perera K. Brain glutathione as a target for aetiological factors in neurolathyrism and konzo. Food Chem Toxicol. 2011;49:662-7 pubmed publisher
  28. Koehorst van Putten H, Wolters A, Pereira Bertram I, van den Berg H, van der Krol A, Visser R. Cloning and characterization of a tuberous root-specific promoter from cassava (Manihot esculenta Crantz). Planta. 2012;236:1955-65 pubmed publisher
    ..These results show that the cassava GBSSI promoter is an excellent candidate to achieve tuberous root-specific expression in cassava...
  29. Soler Martín C, Riera J, Seoane A, Cutillas B, Ambrosio S, Boadas Vaello P, et al. The targets of acetone cyanohydrin neurotoxicity in the rat are not the ones expected in an animal model of konzo. Neurotoxicol Teratol. 2010;32:289-94 pubmed publisher
    ..Similar effects were not elicited by equimolar KCN exposure. Therefore, acetone cyanohydrin may cause selective neuronal degeneration in the rat, but the affected areas are not those expected in an animal model of konzo...
  30. Moreno I, Gruissem W, Vanderschuren H. Reference genes for reliable potyvirus quantitation in cassava and analysis of Cassava brown streak virus load in host varieties. J Virol Methods. 2011;177:49-54 pubmed publisher
    ..The selected reference genes were used as internal controls to quantify CBSV in various symptomatic and asymptomatic plant organs to establish a correlation between virus load and symptom severity...
  31. Sraphet S, Boonchanawiwat A, Thanyasiriwat T, Boonseng O, Tabata S, Sasamoto S, et al. SSR and EST-SSR-based genetic linkage map of cassava (Manihot esculenta Crantz). Theor Appl Genet. 2011;122:1161-70 pubmed publisher
    ..Therefore, sufficient markers now exist to encompass most of the genomes and efficiently map traits in cassava...
  32. Sardos J, McKey D, Duval M, Malapa R, Noyer J, Lebot V. Evolution of cassava (Manihot esculenta Crantz) after recent introduction into a South Pacific Island system: the contribution of sex to the diversification of a clonally propagated crop. Genome. 2008;51:912-21 pubmed publisher
    Cassava (Manihot esculenta Crantz) is a clonally propagated crop that was introduced into the South Pacific archipelago of Vanuatu in the 1850s...
  33. Bradbury J, Cliff J, Denton I. Uptake of wetting method in Africa to reduce cyanide poisoning and konzo from cassava. Food Chem Toxicol. 2011;49:539-42 pubmed publisher
    ..The Ministry of Health in Mozambique is now using our posters in Macua. In Uvira DRC, the wetting method has been taught in many villages and over 1200 posters distributed...
  34. Tsumbu C, Deby Dupont G, Tits M, Angenot L, Franck T, Serteyn D, et al. Antioxidant and antiradical activities of Manihot esculenta Crantz (Euphorbiaceae) leaves and other selected tropical green vegetables investigated on lipoperoxidation and phorbol-12-myristate-13-acetate (PMA) activated monocytes. Nutrients. 2011;3:818-38 pubmed publisher
    Abelmoschus esculentus (Malvaceae), Hibiscus acetosella (Malvaceae), Manihot esculenta Crantz (Euphorbiaceae) and Pteridium aquilinum (Dennstaedtiaceae) leaves are currently consumed as vegetables by migrants from sub-Saharan Africa ..
  35. Adamolekun B. Etiology of Konzo, epidemic spastic paraparesis associated with cyanogenic glycosides in cassava: role of thiamine deficiency?. J Neurol Sci. 2010;296:30-3 pubmed publisher
    ..in Africa, invariably associated with monotonous consumption of inadequately processed bitter cassava roots (Manihot esculenta) with very minimal protein supplementation...
  36. Alves Pereira A, Peroni N, Abreu A, Gribel R, Clement C. Genetic structure of traditional varieties of bitter manioc in three soils in Central Amazonia. Genetica. 2011;139:1259-71 pubmed publisher
    ..This is the first time that genetic divergence of bitter manioc varieties in cultivation in different Amazonian soils in a small geographic area is reported...
  37. Mlingi N, Nkya S, Tatala S, Rashid S, Bradbury J. Recurrence of konzo in southern Tanzania: rehabilitation and prevention using the wetting method. Food Chem Toxicol. 2011;49:673-7 pubmed publisher
    ..This model to help prevent konzo requires the widespread education of women activists to use the wetting method...
  38. Winter S, Koerbler M, Stein B, Pietruszka A, Paape M, Butgereitt A. Analysis of cassava brown streak viruses reveals the presence of distinct virus species causing cassava brown streak disease in East Africa. J Gen Virol. 2010;91:1365-72 pubmed publisher
    ..It is suggested that those of clade 1 retain the species name Cassava brown streak virus, whilst those of clade 2 be classified as Cassava brown streak Mozambique virus...
  39. Yi B, Hu L, Mei W, Zhou K, Wang H, Luo Y, et al. Antioxidant phenolic compounds of cassava (Manihot esculenta) from Hainan. Molecules. 2011;16:10157-67 pubmed publisher
    ..The results showed that these phenolic compounds contributed to the antioxidant activity of cassava...
  40. Sanchez T, Dufour D, Moreno I, Ceballos H. Comparison of pasting and gel stabilities of waxy and normal starches from potato, maize, and rice with those of a novel waxy cassava starch under thermal, chemical, and mechanical stress. J Agric Food Chem. 2010;58:5093-9 pubmed publisher
    ..Waxy cassava starch was the only one not showing any syneresis after 5 weeks of storage at -20 degrees C. Natural waxy cassava starch is, therefore, a promising ingredient to formulate refrigerated or frozen food...
  41. Li Y, Pan Y, Sun C, Dong H, Luo X, Wang Z, et al. An ordered EST catalogue and gene expression profiles of cassava (Manihot esculenta) at key growth stages. Plant Mol Biol. 2010;74:573-90 pubmed publisher
  42. Ferguson M, Hearne S, Close T, Wanamaker S, Moskal W, Town C, et al. Identification, validation and high-throughput genotyping of transcribed gene SNPs in cassava. Theor Appl Genet. 2012;124:685-95 pubmed publisher
    ..The resources presented allow for improved genetic dissection of economically important traits and the application of modern genomics-based approaches to cassava breeding and conservation...
  43. Yadav J, Ogwok E, Wagaba H, Patil B, Bagewadi B, Alicai T, et al. RNAi-mediated resistance to Cassava brown streak Uganda virus in transgenic cassava. Mol Plant Pathol. 2011;12:677-87 pubmed publisher
    ..streak Uganda virus (CBSUV) and Cassava brown streak virus (CBSV), is of new epidemic importance to cassava (Manihot esculenta Crantz) production in East Africa, and an emerging threat to the crop in Central and West Africa...
  44. Whankaew S, Poopear S, Kanjanawattanawong S, Tangphatsornruang S, Boonseng O, Lightfoot D, et al. A genome scan for quantitative trait loci affecting cyanogenic potential of cassava root in an outbred population. BMC Genomics. 2011;12:266 pubmed publisher
    Cassava (Manihot esculenta Crantz) can produce cyanide, a toxic compound, without self-injury. That ability was called the cyanogenic potential (CN)...
  45. Liu J, Zheng Q, Ma Q, Gadidasu K, Zhang P. Cassava genetic transformation and its application in breeding. J Integr Plant Biol. 2011;53:552-69 pubmed publisher
    As a major source of food, cassava (Manihot esculenta Crantz) is an important root crop in the tropics and subtropics of Africa and Latin America, and serves as raw material for the production of starches and bioethanol in tropical Asia...
  46. Blagbrough I, Bayoumi S, Rowan M, Beeching J. Cassava: an appraisal of its phytochemistry and its biotechnological prospects. Phytochemistry. 2010;71:1940-51 pubmed publisher
    ..state of knowledge of the phytochemistry of small molecules isolated from the roots and leaves of cassava, Manihot esculenta Crantz (Euphorbiaceae), is reviewed...
  47. Abbasi B, Ahmed K, Khalique F, Ayub N, Liu H, Raza Kazmi S, et al. Rearing the cotton bollworm, Helicoverpa armigera, on a tapioca-based artificial diet. J Insect Sci. 2007;7:35 pubmed publisher
    ..13 times less than the cost of rearing on the agar-based artificial diet. These results demonstrate the effectiveness and potential cost savings of the tapioca-based artificial diet for rearing H. armigera...
  48. Vanderschuren H, Moreno I, Anjanappa R, Zainuddin I, Gruissem W. Exploiting the combination of natural and genetically engineered resistance to cassava mosaic and cassava brown streak viruses impacting cassava production in Africa. PLoS ONE. 2012;7:e45277 pubmed publisher
    ..The innovative combination of natural and engineered virus resistance in farmer-preferred landraces will be particularly important to reducing the increasing impact of cassava viral diseases in Africa...
  49. Legg J, Jeremiah S, Obiero H, Maruthi M, Ndyetabula I, Okao Okuja G, et al. Comparing the regional epidemiology of the cassava mosaic and cassava brown streak virus pandemics in Africa. Virus Res. 2011;159:161-70 pubmed publisher
    ..This emphasizes the pivotal role played by the vector in both pandemics and the urgent need to identify effective and sustainable strategies for controlling whiteflies on cassava...
  50. Zeng C, Wang W, Zheng Y, Chen X, Bo W, Song S, et al. Conservation and divergence of microRNAs and their functions in Euphorbiaceous plants. Nucleic Acids Res. 2010;38:981-95 pubmed publisher
    ..2%) of the 85 miRNAs in at least one of four Euphorbiaceous species, the Castor bean, the Cassava (Manihot esculenta), the Rubber tree (Hevea brasiliensis) and the Jatropha (Jatropha curcas) during normal seedling ..
  51. Adamolekun B. Neurological disorders associated with cassava diet: a review of putative etiological mechanisms. Metab Brain Dis. 2011;26:79-85 pubmed publisher
    ..epidemic spastic paraparesis (konzo) are two neurological disorders associated with the consumption of cassava (Manihot esculenta) in several African countries...
  52. Mbanzibwa D, Tian Y, Tugume A, Mukasa S, Tairo F, Kyamanywa S, et al. Simultaneous virus-specific detection of the two cassava brown streak-associated viruses by RT-PCR reveals wide distribution in East Africa, mixed infections, and infections in Manihot glaziovii. J Virol Methods. 2011;171:394-400 pubmed publisher
    ..CBSV was also detected in the perennial species Manihot glaziovii (DNA-barcoded in this study) in Tanzania, which revealed the first virus reservoir other than cassava...
  53. Kassa R, Kasensa N, Monterroso V, Kayton R, Klimek J, David L, et al. On the biomarkers and mechanisms of konzo, a distinct upper motor neuron disease associated with food (cassava) cyanogenic exposure. Food Chem Toxicol. 2011;49:571-8 pubmed publisher
    ..g. protein disulfide isomerase), and maintenance of the cytoskeleton integrity (e.g. ?-spectrin). Studies are needed to elucidate the role of the aformentioned modifications in the pathogenesis of cassava-associated motor-system disease...
  54. Llorens J, Soler Martín C, Saldaña Ruíz S, Cutillas B, Ambrosio S, Boadas Vaello P. A new unifying hypothesis for lathyrism, konzo and tropical ataxic neuropathy: nitriles are the causative agents. Food Chem Toxicol. 2011;49:563-70 pubmed publisher
    ..Recently, neuronal degeneration has been found in rats exposed to acetone cyanohydrin. Taken together, the neurotoxic properties of nitriles make them excellent candidates as causative agents for konzo, lathyrism and TAN...