Summary: A plant family of the order Eucommiales, subclass Hamamelidae, class Magnoliopsida (some botanists have classified this in the order Hamamelidales or Urticales). Eucomia is an elmlike tree of central and eastern China. Leaves are alternate; deciduous flowers are solitary and unisexual and lack petals and sepals. The male flowers have 6 to 10 stamens and female flowers have one ovary of two carpels, one of which aborts during development so the fruit (a dry, winged structure) contains only one seed. The latex is a source of RUBBER. Tochu tea is an aqueous extract of Eucommia ulmoides leaves and a popular beverage in Japan. (Mutat Res 1997 Jan 15;388(1):7-20).

Top Publications

  1. Bamba T, Fukusaki E, Nakazawa Y, Kobayashi A. In-situ chemical analyses of trans-polyisoprene by histochemical staining and Fourier transform infrared microspectroscopy in a rubber-producing plant, Eucommia ulmoides Oliver. Planta. 2002;215:934-9 pubmed
  2. Jiang J, Kai G, Cao X, Chen F, He D, Liu Q. Molecular cloning of a HMG-CoA reductase gene from Eucommia ulmoides Oliver. Biosci Rep. 2006;26:171-81 pubmed
    ..Functional complementation of EuHMGR in HMGR-deficient mutant yeast JRY2394 demonstrated that EuHMGR mediates the mevalonate biosynthesis in yeast...
  3. Takeno S, Bamba T, Nakazawa Y, Fukusaki E, Okazawa A, Kobayashi A. Quantification of trans-1,4-polyisoprene in Eucommia ulmoides by fourier transform infrared spectroscopy and pyrolysis-gas chromatography/mass spectrometry. J Biosci Bioeng. 2008;105:355-9 pubmed publisher
    ..We successfully applied the extraction/quantification method for study of seasonal changes in EU-rubber content and molecular weight distribution...
  4. Hirata T, Kobayashi T, Wada A, Ueda T, Fujikawa T, Miyashita H, et al. Anti-obesity compounds in green leaves of Eucommia ulmoides. Bioorg Med Chem Lett. 2011;21:1786-91 pubmed publisher
    ..These results suggest that asperuloside in Eucommia leaves has important anti-obesity effects. ..
  5. Chai X, Wang Y, Su Y, Bah A, Hu L, Gao Y, et al. A rapid ultra performance liquid chromatography-tandem mass spectrometric method for the qualitative and quantitative analysis of ten compounds in Eucommia ulmodies Oliv. J Pharm Biomed Anal. 2012;57:52-61 pubmed publisher
    ..The contents of the investigated compounds varied very remarkably for the bark of E. ulmoides collected from different habitats. This study might provide a comprehensive method for the quality assessment of E. ulmoides. ..
  6. Di L, Liu S, Zhao X, Bi X, Shan J, Mao Y, et al. [Research on the quality changes in pre- and post-processed pieces of Eucommia ulmoides]. Zhong Yao Cai. 2007;30:525-9 pubmed
    ..Processing can reduce the content of pinoresinol diglucoside. Alcohol extract has different changes. Eucommia ulmoides common peaks of its fingerprint reduce and mostly components descend after processed by salt-water. ..
  7. Lee S, Kim H, Song Y, Jung H, Ji S, Jang H, et al. The effect of Eucommia ulmoides leaf supplementation on the growth performance, blood and meat quality parameters in growing and finishing pigs. Anim Sci J. 2009;80:41-5 pubmed publisher
    ..05) in T1 and T2 than in C. The results indicate that the addition of EUL affected growth performance, blood parameters and meat quality parameters in growing and finishing pigs. ..
  8. Hong Y, Liu W, Li T, She S. Optimization of extraction of Eucommia ulmoides polysaccharides by response surface methodology. Carbohydr Polym. 2013;92:1761-6 pubmed publisher
    ..The findings indicate that the extract of E. ulmoides polysaccharides can protect the kidney against IR induced oxidative damage in rabbits. ..
  9. Duan L, Li M, Liu H. Biosynthesised palladium nanoparticles using Eucommia ulmoides bark aqueous extract and their catalytic activity. IET Nanobiotechnol. 2015;9:349-54 pubmed publisher
    ..The PdNPs show excellent catalytic activity for the electro-catalytic oxidation of hydrazine and the catalytic reducing degradation of p-aminoazobenzene, a model compound of azo-dyes. ..

More Information

Publications102 found, 100 shown here

  1. Koh W, Shin J, Lee J, Lee I, Lee S, Ha I, et al. Anti-inflammatory effect of Cortex Eucommiae via modulation of the toll-like receptor 4 pathway in lipopolysaccharide-stimulated RAW 264.7 macrophages. J Ethnopharmacol. 2017;209:255-263 pubmed publisher
    ..CE down-regulated both Myd88-dependent and independent TLR-4 pathways, thus exerting anti-inflammatory effects. These results suggest that CE may be used as a potential therapeutic agent against chronic inflammatory diseases. ..
  2. Zhang R, Liu Z, Li C, Hu S, Liu L, Wang J, et al. Du-Zhong (Eucommia ulmoides Oliv.) cortex extract prevent OVX-induced osteoporosis in rats. Bone. 2009;45:553-9 pubmed publisher
  3. Zhu H, Di H, Zhang Y, Zhang J, Chen D. A protein-bound polysaccharide from the stem bark of Eucommia ulmoides and its anti-complementary effect. Carbohydr Res. 2009;344:1319-24 pubmed publisher
    ..The results suggested that EWDS-2 could be valuable for the treatment of diseases associated with the excessive activation of the complement system. ..
  4. Nam J, Kim S, Yoon T, Lee Y, Kil Y, Lee Y, et al. Heat shock factor 1 inducers from the bark of Eucommia ulmoides as cytoprotective agents. Chem Biodivers. 2013;10:1322-7 pubmed publisher
    The barks of Eucommia ulmoides (Eucommiae Cortex, Eucommiaceae) have been used as a traditional medicine in Korea, Japan, and China to treat hypertension, reinforce the muscles and bones, and recover the damaged liver and kidney functions...
  5. Li C, Qiu G, Liu B, Chen J, Fu H. Neuroprotective effect of lignans extracted from Eucommia ulmoides Oliv. on glaucoma-related neurodegeneration. Neurol Sci. 2016;37:755-62 pubmed publisher
    ..This study provides evidence that lignans possesses protective effect on glaucoma-associated optic neuropathy. Lignans might be an alternative for the prevention and treatment of glaucomatous neurodegeneration. ..
  6. Li H, Chen B, Nie L, Yao S. Solvent effects on focused microwave assisted extraction of polyphenolic acids from Eucommia ulmodies. Phytochem Anal. 2004;15:306-12 pubmed
    ..The repeatability test of extraction and chromatographic analysis was satisfactory for the analysis of these polyphenolic compounds. ..
  7. Lee M, Kim M, Cho S, Park S, Park K, Jung U, et al. Hypoglycemic effect of Du-zhong (Eucommia ulmoides Oliv.) leaves in streptozotocin-induced diabetic rats. Diabetes Res Clin Pract. 2005;67:22-8 pubmed
    ..They improved hyperglycemia and seemingly enhance the function of pancreatic beta-cells in STZ-induced diabetic rats. ..
  8. Kubota Y, Umegaki K, Kobayashi K, Tanaka N, Kagota S, Nakamura K, et al. Anti-hypertensive effects of Brazilian propolis in spontaneously hypertensive rats. Clin Exp Pharmacol Physiol. 2004;31 Suppl 2:S29-30 pubmed
    ..3. These results suggest that propolis and tochu produce an antihypertensive effect that may be mediated by potentiation of acetylcholine-induced vasodilatation. ..
  9. Cao H, Chen X, Xlao J, Tang Z, Ouyang D. [Isolation, purification and identification of geniposidic acid in Eucommia ulmoides oliv. by silica column chromatography, reversed-phase high performance liquid chromatography, liquid chromatography-electrospray ionization mass spectrometry and nuc. Se Pu. 2005;23:534-7 pubmed
    ..The ultraviolet and infrared spectra of the eluted solution were essentially the same to those of GPA. On the other hand, LC-ESI-MS, 1H- and 13C-NMR experiments also indicated that the fraction was identical to GPA. ..
  10. Li L, Guo Y, Zhao L, Zu Y, Gu H, Yang L. Enzymatic Hydrolysis and Simultaneous Extraction for Preparation of Genipin from Bark of Eucommia ulmoides after Ultrasound, Microwave Pretreatment. Molecules. 2015;20:18717-31 pubmed publisher
    ..The results indicated that the EHSE method provided a good alternative for the preparation of genipin from Eucommia ulmoides bark as well as other herbs. ..
  11. Cho S, Hong R, Yim P, Yeom M, Lee B, Yang W, et al. An herbal formula consisting of Schisandra chinensis (Turcz.) Baill, Lycium chinense Mill and Eucommia ulmoides Oliv alleviates disuse muscle atrophy in rats. J Ethnopharmacol. 2018;213:328-339 pubmed publisher
    ..Taken together, we conclude that the SSLE formula is invaluable for the development of therapeutic medicines to prevent disuse muscle atrophy and its accompanying muscle weakness. ..
  12. Sun Q, Zhao X, Wang D, Dong J, She D, Peng P. Preparation and characterization of nanocrystalline cellulose/Eucommia ulmoides gum nanocomposite film. Carbohydr Polym. 2018;181:825-832 pubmed publisher
    ..28×10-9, 0.30×10-9, and 0.58×10-9g/m/h/Pa at RH 34%, 55%, and 76%, respectively. ..
  13. Guan S, Su W. [Advances in the study of chemical constituents and pharmacology of Eucommia ulmoides Oliver]. Zhong Yao Cai. 2003;26:124-9 pubmed
  14. Liang S, Sun H. [Determination of six nutritional elements in Chinese herbal medicines by graphite furnace atomic absorption spectrometry]. Guang Pu Xue Yu Guang Pu Fen Xi. 2002;22:847-9 pubmed
    ..Makino were obviously higher than other herbal drugs. They are worth much more comprehensive utilization. The relation between concentrations of these nutritional elements and curative effect was also discussed...
  15. Zhang Q, Su Y, Zhang J. Seasonal difference in antioxidant capacity and active compounds contents of Eucommia ulmoides oliver leaf. Molecules. 2013;18:1857-68 pubmed publisher
    ..Flavonoids played an important role in the inhibitory effects on rapeseed oil and linoleic acid oxidation. Therefore, August and May were indicated as the best months to harvest EU leaves for industry. ..
  16. Sun G, Shih J, Chiou S, Hong C, Lu S, Pao L. Chinese herbal medicines promote hippocampal neuroproliferation, reduce stress hormone levels, inhibit apoptosis, and improve behavior in chronically stressed mice. J Ethnopharmacol. 2016;193:159-168 pubmed publisher
    ..The possible mechanisms of action include modulation of the HPA axis, reduction in stress hormone levels, inhibition of apoptosis, and promotion of hippocampal neuronal plasticity and neurogenesis. ..
  17. Dai X, Huang Q, Zhou B, Gong Z, Liu Z, Shi S. Preparative isolation and purification of seven main antioxidants from Eucommia ulmoides Oliv. (Du-zhong) leaves using HSCCC guided by DPPH-HPLC experiment. Food Chem. 2013;139:563-70 pubmed publisher
    ..ulmoides leaves by HSCCC. The results indicated that the combinative methods using DPPH-HPLC and HSCCC could be widely applied for screening and isolation of antioxidants from complex extracts. ..
  18. Gong X, Luan Q, Zhou X, Zhao Y, Zhao C. UHPLC-ESI-MS/MS determination and pharmacokinetics of pinoresinol glucoside and chlorogenic acid in rat plasma after oral administration of Eucommia ulmoides Oliv extract. Biomed Chromatogr. 2017;31: pubmed publisher
    ..46 and 5.15%, respectively, and the accuracy (RE) values ranged from -12.76 to 0.00. This is the first study on pharmacokinetics of bioactive compounds in rat plasma after oral administration of E. ulmoides extract. ..
  19. Li K, Liu M, Wei X. [Study of xixin, duzhong and mixture to the antioxidant system of D-galactose-induced senile mice]. Zhong Yao Cai. 2000;23:161-3 pubmed
    ..01); Xixin and Duzhong could enhance the activity of SOD, GSH-Px and NOS; The time of effect for mixture and Duzhong to above index was short than Xixin's. The time of Mixture and Duzhong was 15 days, and Xixin was 30 days. ..
  20. Zhang W, Li G, Dong H, Liu Z, Xiong C. [The effects of eucommia ulmoides oliv on catching action of diabetic rats and myelinated nerve fibers in penile tissues]. Zhonghua Nan Ke Xue. 2006;12:466-9 pubmed
    ..By remitting the impairement of myelinated nerve fibers and enhancing the expression of nNOS in penile tissue, eucommia ulmoides oliv can improve erectile function of diabetic rats. ..
  21. Wang A, Huang L, Shao A, Cui G, Chen M, Tong C. [Genetic diversity of Eucommia ulmoides by RAPD analysis]. Zhongguo Zhong Yao Za Zhi. 2006;31:1583-6 pubmed
    ..65% within populations. The genetic variation was relatively high in E. ulmoides, so the genetic diversity conservation principle should mainly focus on protection of the populations. ..
  22. Dong J, Ma X. [Determination of geniposidic acid and chlorogenic acid in male flowers and related products of Eucommia ulmoides by reversed-phase high performance liquid chromatography]. Se Pu. 2007;25:217-20 pubmed
    ..It is suitable for the determination of the two compounds in the male flowers of E. ulmoides and related products. ..
  23. Ma X, Gao W, Zhang L, Chen Z, Xiao F, Yuan D. [Effects of growth regulator, full exposure and mist spray on the cutting of Eucommia ulmoides]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2001;23:552-5 pubmed
    ..The present study shows that both full exposure mist spray and growth regulators have remarkable effects on cuttings of tree with different ages for rooting or forming callus. ..
  24. Lv P, Feng H, Huang W, Tian Y, Wang Y, Qin Y, et al. Aucubin and its hydrolytic derivative attenuate activation of hepatic stellate cells via modulation of TGF-? stimulation. Environ Toxicol Pharmacol. 2017;50:234-239 pubmed publisher
    ..Taken together, aucubin and aucubigenin both inhibit the activation and ECM deposition of LX-2 cells activated by TGF-?1. Aucubin and aucubigenin are potential therapeutic candidate drugs for liver fibrosis. ..
  25. Jing T, Wang L, Liu H, Wuyun T, Du H. Genome-Wide Identification of Mitogen-activated Protein Kinase Cascade Genes and Transcriptional Profiling Analysis during Organ Development in Eucommia ulmoides. Sci Rep. 2017;7:17732 pubmed publisher
    ..Overall, our results could be used for further research on the precise role of MAPK cascades during organ development in E. ulmoides. ..
  26. Yang Z, Jiang Y, Ge F, Yuan Y, Yu S. [Study on isolation of Chlorogenic acid from Eucommia ulmoides leaves by ultrafiltration technique]. Zhong Yao Cai. 2008;31:585-8 pubmed
    ..38%. High Chlorogenic acid transfering ratio can be gotten by ultrafiltration technique, which is helpful to the further isolation and purification of Chlorogenic acid in the subsequent process. ..
  27. Chen R, Harada Y, Bamba T, Nakazawa Y, Gyokusen K. Overexpression of an isopentenyl diphosphate isomerase gene to enhance trans-polyisoprene production in Eucommia ulmoides Oliver. BMC Biotechnol. 2012;12:78 pubmed publisher
    ..Our results demonstrated that regulation of IPI expression is a key target for efficient production of trans-polyisoprene in E. ulmoides. ..
  28. Wang J, Yuan Y, Chen X, Fu S, Zhang L, Hong Y, et al. Extract from Eucommia ulmoides Oliv. ameliorates arthritis via regulation of inflammation, synoviocyte proliferation and osteoclastogenesis in vitro and in vivo. J Ethnopharmacol. 2016;194:609-616 pubmed publisher
  29. Wang W, Zhang X. Identification of the Sex-Biased Gene Expression and Putative Sex-Associated Genes in Eucommia ulmoides Oliver Using Comparative Transcriptome Analyses. Molecules. 2017;22: pubmed publisher
    ..In addition, the SNPs density was 1.02 per kilobase (kb) in the expressed genes of E. ulmoides, implying a relatively high genetic diversity. ..
  30. Zhang X, Cheng C, Zhang M, Lan X, Wang Q, Han S. Effect of alkali and enzymatic pretreatments of Eucommia ulmoides leaves and barks on the extraction of gutta percha. J Agric Food Chem. 2008;56:8936-43 pubmed publisher
    ..2%. The tensile strength of obtained gutta percha increased from 0.02 MPa of milled Eucommia leaves to 60.5 MPa, the breakage extensibility ranged from about 0 to 24%, and the tearing strength ranged from 0.5 to 36 kN/m. ..
  31. Dong X, Zhao Y, Ran X, Guo L, Zhao D. Overexpression of a New Chitinase Gene EuCHIT2 Enhances Resistance to Erysiphe cichoracearum DC in Tobacco Plants. Int J Mol Sci. 2017;18: pubmed publisher
    ..cichoracearum DC. The present study supports the notion that PR-1a and POD participate in resistance to E. cichoracearum DC in the transgenic tobacco plants. ..
  32. Zhang W, Fujikawa T, Mizuno K, Ishida T, Ooi K, Hirata T, et al. Eucommia leaf extract (ELE) prevents OVX-induced osteoporosis and obesity in rats. Am J Chin Med. 2012;40:735-52 pubmed publisher
    ..These results suggest that ELE may have curative properties for BMD and BMI in OVX rats, and could provide an alternative therapy for the prevention of both postmenopausal osteoporosis and obesity. ..
  33. Li Q, Feng Y, He W, Wang L, Wang R, Dong L, et al. Post-screening characterisation and in vivo evaluation of an anti-inflammatory polysaccharide fraction from Eucommia ulmoides. Carbohydr Polym. 2017;169:304-314 pubmed publisher
    ..In summary, EUP1, with a clearly elucidated chemical structure and solid anti-inflammatory activity, may become a valuable candidate for further development into an anti-septic therapeutic agent. ..
  34. Wu H, Lin Y. Effect of Eucommia ulmoides Oliv., Gynostemma pentaphyllum (Thunb.) Makino, and Curcuma longa L. on Th1- and Th2-cytokine responses and human leukocyte antigen-DR expression in peripheral blood mononuclear cells of septic patients. J Ethnopharmacol. 2018;217:195-204 pubmed publisher
    ..By enhancing monocyte HLA-DR expression and decreasing IL-10 production, C. longa L. might help restore inflammatory responses in septic patients to eradicate pathogens. ..
  35. Kwan C, Zhang W, Deyama T, Nishibe S. Endothelium-dependent vascular relaxation induced by Eucommia ulmoides Oliv. bark extract is mediated by NO and EDHF in small vessels. Naunyn Schmiedebergs Arch Pharmacol. 2004;369:206-11 pubmed
    ..Results of our study offer a plausible mechanistic basis for the vasorelaxing action of Eucommia ulmoides Oliv., which may account for its well-documented antihypertensive action...
  36. Park S, Choi M, Kim M, Jung U, Kim H, Park K, et al. Hypoglycemic and hypolipidemic action of Du-zhong (Eucommia ulmoides Oliver) leaves water extract in C57BL/KsJ-db/db mice. J Ethnopharmacol. 2006;107:412-7 pubmed
  37. Shi J, Liu C, Liu L, Yang B, Zhang Y. Structure identification and fermentation characteristics of pinoresinol diglucoside produced by Phomopsis sp. isolated from Eucommia ulmoides Oliv. Appl Microbiol Biotechnol. 2012;93:1475-83 pubmed publisher
    ..During the fermentation, PDG production outside cells starts at the later stage of cell growth when the residual sugar in the medium was low. The study reveals the possibility for production of PDG by fermentation...
  38. Huang R, Xiang Y, Tu G, Zhang Y, Wang D. Solution structure of Eucommia antifungal peptide: a novel structural model distinct with a five-disulfide motif. Biochemistry. 2004;43:6005-12 pubmed
    ..On the basis of such a structural feature, the possible structural basis for the functional properties of EAFP2 is discussed...
  39. Li H, Liu Y, Zhang Z, Liao H, Nie L, Yao S. Separation and purification of chlorogenic acid by molecularly imprinted polymer monolithic stationary phase. J Chromatogr A. 2005;1098:66-74 pubmed
    ..This approach was shown to be successful for the separation and purification of chlorogenic acid from the extract of Eucommia ulmodies leaves...
  40. Hou H, Zhou Y, Mwange K, Li W, He X, Cui K. ABP1 expression regulated by IAA and ABA is associated with the cambium periodicity in Eucommia ulmoides Oliv. J Exp Bot. 2006;57:3857-67 pubmed
    ..This paper attempts to explain why IAA would 'boost' the reactivation of a quiescent cambium, and not that of a resting cambium. Results also show that ABP1 expression is improved by IAA, while inhibited by ABA...
  41. Takamura C, Hirata T, Ueda T, Ono M, Miyashita H, Ikeda T, et al. Iridoids from the green leaves of Eucommia ulmoides. J Nat Prod. 2007;70:1312-6 pubmed
    ..Furthermore, 2 and 3 may be regarded as the first naturally occurring conjugates of an iridoid and an amino acid...
  42. Kwon S, Lee H, Kim J, Hong S, Kim S, Jo T, et al. Neuroprotective effects of Eucommia ulmoides Oliv. Bark on amyloid beta(25-35)-induced learning and memory impairments in mice. Neurosci Lett. 2011;487:123-7 pubmed publisher
  43. Li W, Sun S, Qin J, Yi Y, Yang M. [Quantitative determination of pinoresinol diglucoside in Eucommiae unloads by NIRS]. Zhongguo Zhong Yao Za Zhi. 2010;35:3318-21 pubmed
    ..To establish a rapid determination method of pinoresinol diglucoside in Eucommiae unloads by near-infrared reflectance spectroscopy (NIRS)...
  44. Li L, Yan J, Hu K, Gu J, Wang J, Deng X, et al. Protective effects of Eucommia lignans against hypertensive renal injury by inhibiting expression of aldose reductase. J Ethnopharmacol. 2012;139:454-61 pubmed publisher
    ..To investigate the protective effects and the underlying mechanism of Eucommia lignans against hypertensive renal injury...
  45. Suzuki N, Uefuji H, Nishikawa T, Mukai Y, Yamashita A, Hattori M, et al. Construction and analysis of EST libraries of the trans-polyisoprene producing plant, Eucommia ulmoides Oliver. Planta. 2012;236:1405-17 pubmed publisher
    ..This study should provide a valuable resource for further studies of rubber synthesis in E. ulmoides...
  46. Li Z, Gu J, Yan J, Wang J, Huang W, Tan Z, et al. Hypertensive cardiac remodeling effects of lignan extracts from Eucommia ulmoides Oliv. bark--a famous traditional Chinese medicine. Am J Chin Med. 2013;41:801-15 pubmed publisher
    ..05). Therefore, lignan extracts could prevent hypertensive cardiac remodeling, which is likely related to aldose reductase inhibition. ..
  47. Sun Y, Dong J, Wu S. [Studies on chemical constituents from Eucommia ulmoides Oliv]. Zhong Yao Cai. 2004;27:341-3 pubmed
    ..To study the chemical constituents from Eucommia ulmoides Oliv...
  48. Feng S, Gan Z, Zhai X, Fu P, Sun W. [Content comparison of pinoresinol diglucoside in original and reborn bark of Eucommia ulmoides]. Zhong Yao Cai. 2006;29:792-4 pubmed
    ..To evaluate the reborn barks quality, antihypertensive effective component of pinoresnol diglucoside (PDG) in three times reborn barks were determined...
  49. Zhao X, Sun X, Zhang Z, Hui J. [Experimental studies on compound Duzhong Jiangya prescription by semi-bionic extraction]. Zhongguo Zhong Yao Za Zhi. 2007;32:2247-52 pubmed
    ..Optimize the technic condition of Duzhong Jiangya prescription with Semi-bionic Extraction...
  50. Jin X, Amitani K, Zamami Y, Takatori S, Hobara N, Kawamura N, et al. Ameliorative effect of Eucommia ulmoides Oliv. leaves extract (ELE) on insulin resistance and abnormal perivascular innervation in fructose-drinking rats. J Ethnopharmacol. 2010;128:672-8 pubmed publisher
    ..leaves extract (ELE) ameliorates pre-diabetic state of insulin resistance and abnormal perivascular innervation in the hyperinsulinemic state...
  51. Horii Y, Tanida M, Shen J, Hirata T, Kawamura N, Wada A, et al. Effects of Eucommia leaf extracts on autonomic nerves, body temperature, lipolysis, food intake, and body weight. Neurosci Lett. 2010;479:181-6 pubmed publisher
  52. Mwange K, Hou H, Cui K. Relationship between endogenous indole-3-acetic acid and abscisic acid changes and bark recovery in Eucommia ulmoides Oliv. after girdling. J Exp Bot. 2003;54:1899-907 pubmed
    Eucommia ulmoides (Eucommiaceae), a traditional Chinese medicinal plant, is often subjected to severe manual peeling of its bark. If the girdled trunk is well protected from desiccation, new bark forms within 1 month...
  53. Kim H, Moon B, Lee H, Choi D. Flavonol glycosides from the leaves of Eucommia ulmoides O. with glycation inhibitory activity. J Ethnopharmacol. 2004;93:227-30 pubmed
    ..The results suggest that the flavonol glycosides with glycation inhibitory activity could be attributed to the anti-diabetic action of Eucommia ulmoides leaves...
  54. Kwan C, Chen C, Deyama T, Nishibe S. Endothelium-dependent vasorelaxant effects of the aqueous extracts of the Eucommia ulmoides Oliv. leaf and bark: implications on their antihypertensive action. Vascul Pharmacol. 2003;40:229-35 pubmed
    ..Results in this study have provided the first evidence on the in vitro vasorelaxant action of E. ulmoides Oliv. that forms the pharmacological basis for its well-documented antihypertensive action...
  55. Ho J, Lee Y, Lee Y, Jun W, Kim H, Hong B, et al. Inhibitory effect of Aucubin isolated from Eucommia ulmoides against UVB-induced matrix metalloproteinase-1 production in human skin fibroblasts. Biosci Biotechnol Biochem. 2005;69:2227-31 pubmed
    ..It also reduced MMP-1 mRNA expression. These results suggest that aucubin is a photoprotective phytochemical, and could be used as a potential agent in preventing photoaging...
  56. Hung M, Fu T, Shih P, Lee C, Yen G. Du-Zhong (Eucommia ulmoides Oliv.) leaves inhibits CCl4-induced hepatic damage in rats. Food Chem Toxicol. 2006;44:1424-31 pubmed
    ..The data suggest that oral administration with WEDZ for 28 consecutive days significantly decrease the intensity of hepatic damage induced by CCl4 in rats...
  57. Wang Z, Clifford M. Comparison of the profiles of chlorogenic acids and their derivatives from three Chinese traditional herbs by LC-MSn. Yao Xue Xue Bao. 2008;43:185-90 pubmed
    ..The comparatively unusual profile of caffeoylquinic acids in Houttuynla cordata Thunb. makes it a convenient source of 3-CQA and 4-CQA that are not commercially available...
  58. Jiang L, Wang Z, Zhu H, Di H, Li H, Zhang Y, et al. Beneficial effect of Eucommia polysaccharides on systemic lupus erythematosus-like syndrome induced by Campylobacter jejuni in BALB/c mice. Inflammation. 2011;34:402-11 pubmed publisher
    ..These findings suggested that Eucommia polysaccharides had a beneficial effect on systemic lupus erythematosus-like syndrome induced by CJ-S(131) in BALB/c mice...
  59. Li X, Zhu W, Yang L, Fei D, Fan J, Du L, et al. Evaluation of the sedative and hypnotic effects of Eucommiol in Eucommia. Nat Prod Res. 2013;27:1657-9 pubmed publisher
    ..In addition, could effectively shorten sleep latency, reduce convulsion rate and prolong convulsion latency. These findings intensely indicated that Eucommiol has excellent sedative and hypnotic effects. ..
  60. Nakazawa Y, Takeda T, Suzuki N, Hayashi T, Harada Y, Bamba T, et al. Histochemical study of trans-polyisoprene accumulation by spectral confocal laser scanning microscopy and a specific dye showing fluorescence solvatochromism in the rubber-producing plant, Eucommia ulmoides Oliver. Planta. 2013;238:549-60 pubmed publisher
  61. Kajiura H, Suzuki N, Tokumoto Y, Yoshizawa T, Takeno S, Fujiyama K, et al. Two Eucommia farnesyl diphosphate synthases exhibit distinct enzymatic properties leading to end product preferences. Biochimie. 2017;139:95-106 pubmed publisher
    ..Taken together, the results indicate that the biosynthesis of FPP is highly regulated by various factors indispensable for EuFPS reactions in plants. ..
  62. Cheng J, Bai Y, Zhao Y, Wang B, Cheng T. [Studies on the phenylpropanoids from Eucommia ulmoides]. Zhongguo Zhong Yao Za Zhi. 2002;27:38-40 pubmed
    ..To study the chemical constituents from the leaves of Eucommia ulmoides...
  63. Xu J, Song Y, Ji H. [Vasodilation effect of EUL on rat thoracic artery]. Zhongguo Zhong Yao Za Zhi. 2006;31:1976-8 pubmed
    ..To observe vasodilation effect of EUL and its mechanism...
  64. Takeno S, Bamba T, Nakazawa Y, Fukusaki E, Okazawa A, Kobayashi A. High-throughput and highly sensitive analysis method for polyisoprene in plants by pyrolysis-gas chromatography/mass spectrometry. Biosci Biotechnol Biochem. 2010;74:13-7 pubmed
    ..This novel quantification method eliminated extraction steps and can be used in the measurement of polyisoprene contents in Eucommia ulmoides and Hevea brasiliensis...
  65. Greenway F, Liu Z, Yu Y, Gupta A. A clinical trial testing the safety and efficacy of a standardized Eucommia ulmoides Oliver bark extract to treat hypertension. Altern Med Rev. 2011;16:338-47 pubmed
    ..A tea made from Eucommia ulmoides leaves and bark is part of the Japanese diet. Eucommia is an herbal medicine that, by increasing nitric oxide, reduced blood pressure (BP) in rats and humans in an uncontrolled clinical trial...
  66. Kim M, Kim D, Kim S, Park J, Kim H, Kim S, et al. Eucommiae cortex inhibits TNF-? and IL-6 through the suppression of caspase-1 in lipopolysaccharide-stimulated mouse peritoneal macrophages. Am J Chin Med. 2012;40:135-49 pubmed
    ..Furthermore, EC suppresses the activation of nuclear factor-kappa B and caspase-1. These results provide novel insights into the pharmacological action of EC and indicate that EC has a potential in the treatment of inflammatory diseases...
  67. Chen H, Pang Y, Zeng J, Ding Q, Yin S, Liu C, et al. The Ca2+ -dependent DNases are involved in secondary xylem development in Eucommia ulmoides. J Integr Plant Biol. 2012;54:456-70 pubmed publisher
    ..Secondary xylem cell differentiation is influenced by RNAi of endonuclease genes. The results provide evidence that the Ca(2+) -dependent DNases are involved in secondary xylem development...
  68. Kwon S, Kim M, Ma S, You I, Hwang J, Oh J, et al. Eucommia ulmoides Oliv. Bark. protects against hydrogen peroxide-induced neuronal cell death in SH-SY5Y cells. J Ethnopharmacol. 2012;142:337-45 pubmed publisher
    ..Bark. (EUE), has commonly been used to fortify the muscles and lungs, lower blood pressure, prevent miscarriage, improve the tone of liver and kidneys, and promote longevity the traditional tonic medicines of Korea, China, and Japan...
  69. Harada M, Sweed H, Catanzaro R, Kumari A, Bomba A, Minelli E, et al. Beneficial modification of functional renal parameters in 5/6 nephrectomized rats by nutraceutical. In view of a kidney-protective intervention. Acta Biomed. 2011;82:200-7 pubmed
    ..These data suggest that feeding with a normal protein diet and DTS supplementation improves renal function without any morphological effect in 5/6 nephrectomized rats if not a slight preservation.(
  70. Zhao J, Wu H, Niu J, Yu Y, Yu L, Kang C, et al. Chemometric resolution of coeluting peaks of eleven antihypertensives from multiple classes in high performance liquid chromatography: a comprehensive research in human serum, health product and Chinese patent medicine samples. J Chromatogr B Analyt Technol Biomed Life Sci. 2012;902:96-107 pubmed publisher
  71. Peng M, Zhang Y, Shi S, Peng S. Simultaneous ligand fishing and identification of human serum albumin binders from Eucommia ulmoides bark using surface plasmon resonance-high performance liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2013;940:86-93 pubmed publisher
  72. Yan J, Ding L, Shi X, Donkor P, Chen L, Qiu F. Megastigmane glycosides from leaves of Eucommia ulmoides Oliver with ACE inhibitory activity. Fitoterapia. 2017;116:121-125 pubmed publisher
    ..The results showed that the isolates (2, 3, 4, 5, 7) had moderate inhibitory effects on ACE in vitro compared with captopril. ..
  73. Xiang Y, Huang R, Liu W, Li G, Liu X, Wang D. Crystallization and preliminary crystallographic studies of a novel antifungal protein with five disulfide bridges from Eucommia ulmoides Oliver. Acta Crystallogr D Biol Crystallogr. 2002;58:1838-40 pubmed
    ..01, b = 23.16, c = 30.69 A, beta = 98.54 degrees. 1.0 A resolution data were collected from an EAFP2 crystal and have been used to obtain phase information directly by an ab initio method...
  74. Park S, Choi M, Jung U, Kim M, Kim D, Park H, et al. Eucommia ulmoides Oliver leaf extract increases endogenous antioxidant activity in type 2 diabetic mice. J Med Food. 2006;9:474-9 pubmed
    ..These results suggest that the antioxidant activity of Du-zhong extract is potentially beneficial for the prevention and management of complications of type 2 diabetes...
  75. Huang Z, Li F, Cao Y, Wang Z, Ouyang Z, Zheng H, et al. [Dynamics of soil water under Eucommia ulmodes plantation in hilly red soil region of southern China]. Ying Yong Sheng Tai Xue Bao. 2007;18:1937-44 pubmed
    ..05). With the extension of drought duration after rain, soil water loss tended to vary gently with increasing soil depth...
  76. Marotta F, Harada M, Minelli E, Yadav H, Polimeni A, Lorenzetti A, et al. Progression of atherosclerotic lesions in the arteries and related gene expression: protective effect of phytonutrients. Rejuvenation Res. 2010;13:242-5 pubmed publisher
    ..05). DTS significantly attenuated inflammatory mechanisms preceding atherogenesis with reduced LDL susceptibility to oxidation-aggregation...
  77. Yang Y, Yin B, Lv L, Wang Z, He J, Chen Z, et al. Gastroprotective effect of aucubin against ethanol-induced gastric mucosal injury in mice. Life Sci. 2017;189:44-51 pubmed publisher
    ..Furthermore, aucubin enhanced gastric mucosal protection by up-regulation of HSP-70 level and normalization of EGF, VEGF and COX-1 levels. ..
  78. Hua H, Yin H, Li B, Hu B, Pei Y. A new monoterpene from the bark of Eucommia ulmoides. J Asian Nat Prod Res. 2002;4:201-4 pubmed
    A new monoterpene, eucommidiol (1), was isolated from the bark of Eucommia ulmoides Oliv. (Eucommiaceae), together with a known compound 1,4a,5,7a-tetrahydro-7-hydroxymethyl-cyclopenta[c]pyran-4-carboxylic methyl ester...
  79. Zhang W, Liu Z, Liu C, Zhu C, Xiong C, Dong H. [Effect of eucommia ulmoides oliv on SOD activity and alpha-actin expression in the penile tissues of diabetic rats]. Zhonghua Nan Ke Xue. 2005;11:309-13 pubmed
    ..To study the effect of aqueous abstract from eucommia ulmoides oliv on the activity of superoxide dismutase (SOD) and alpha-actin expression in the penile tissues of rats with diabetes mellitus (DM) in vitro...
  80. Zhang Z, Yan R, Qiu X, Zeng Q, You H, Zhu D. [Accumulation of flavonoids and chlorogenic acid in callus and suspension cell of Eucommia ulmoides]. Zhongguo Zhong Yao Za Zhi. 2009;34:1636-9 pubmed
    ..To analyze and compare the cell growth and accumulation of flavonoids and chlorogenic acid in the callus and suspension cell of Eucommia ulmoides...
  81. Lv Z, Di L, Zhao X, Cai B, Jin H. [Study on the quality standards of decoction pieces of salt Eucommia]. Zhong Yao Cai. 2010;33:30-3 pubmed
    ..To establish the quality criteria of decoction pieces of salt Eucommia...
  82. Li Y, Wang M, Li S, Zhang Y, Zhao Y, Xie R, et al. Effect of total glycosides from Eucommia ulmoides seed on bone microarchitecture in rats. Phytother Res. 2011;25:1895-7 pubmed publisher
    ..To conclude, TGEUS taken orally increased bone density and altered bone histomorphology, suggesting that TGEUS might be a potential alternative medicine for the treatment of postmenopausal osteoporosis...
  83. Zhang Y, Peng M, Liu L, Shi S, Peng S. Screening, identification, and potential interaction of active compounds from Eucommia ulmodies leaves binding with bovine serum albumin. J Agric Food Chem. 2012;60:3119-25 pubmed publisher
  84. Shi S, Peng M, Zhang Y, Peng S. Combination of preparative HPLC and HSCCC methods to separate phosphodiesterase inhibitors from Eucommia ulmoides bark guided by ultrafiltration-based ligand screening. Anal Bioanal Chem. 2013;405:4213-23 pubmed publisher
    ..The method developed could be widely applied for high-throughput screening and preparative isolation of PDE inhibitors from natural products...
  85. Deyama T, Nishibe S, Nakazawa Y. Constituents and pharmacological effects of Eucommia and Siberian ginseng. Acta Pharmacol Sin. 2001;22:1057-70 pubmed
    The bark and leaves of Eucommia ulmoides Oliv (Eucommiaceae) and "Siberian ginseng" (Ezoukogi in Japanese) prepared from the root bark or stem bark of Eleutherococcus senticosus Maxim (Acanthopanax senticosus Harms) have been ..
  86. Lang C, Liu Z, Taylor H, Baker D. Effect of Eucommia ulmoides on systolic blood pressure in the spontaneous hypertensive rat. Am J Chin Med. 2005;33:215-30 pubmed
    ..BP declined at a rate of approximately 10 mmHg per hour. The mid dosage of 600 mg/kg was found to be the minimum effective dose. In conclusion, E. ulmoides extract was non-toxic and effective in reducing systolic BP in the SHR...
  87. Chande N, Laidlaw M, Adams P, Marotta P. Yo Jyo Hen Shi Ko (YHK) improves transaminases in nonalcoholic steatohepatitis (NASH): a randomized pilot study. Dig Dis Sci. 2006;51:1183-9 pubmed
    ..YHK is well tolerated. Further studies are justified to assess the impact of YHK in the natural history of NASH...
  88. Bamba T, Murayoshi M, Gyoksen K, Nakazawa Y, Okumoto H, Katto H, et al. Contribution of mevalonate and methylerythritol phosphate pathways to polyisoprenoid biosynthesis in the rubber-producing plant Eucommia ulmoides oliver. Z Naturforsch C. 2010;65:363-72 pubmed
    ..ulmoides. It is assumed that the cross-talk of isopentenyl diphosphate, derived from both pathways, occurs during the biosynthesis of polyisoprenoid; therefore, it was observed in the formation of low-molecular weight isoprenoids...
  89. Wang J, Liu E, Zhang Y, Wang T, Han L, Gao X. Validation of a HPLC-tandem MS/MS method for pharmacokinetics study of (+)-pinoresinol-di-?-D-glucopyranoside from Eucommia ulmoides Oliv extract in rats' plasma. J Ethnopharmacol. 2012;139:337-42 pubmed publisher
    ..The obtained pharmacokinetic parameters shown that PG pertains to one-compartment model and 95% of PG was eliminated within 12h...
  90. Niu H, Liu I, Niu C, Ku P, Hsu C, Cheng J. Eucommia bark (Du-Zhong) improves diabetic nephropathy without altering blood glucose in type 1-like diabetic rats. Drug Des Devel Ther. 2016;10:971-8 pubmed publisher
    ..In an attempt to develop this herb as a treatment for diabetic nephropathy (DN), we investigated the effects of Du-Zhong on renal dysfunction in type 1-like diabetic rats...
  91. Wang J, Li Y, Huang W, Zeng X, Li X, Li J, et al. The Protective Effect of Aucubin from Eucommia ulmoides Against Status Epilepticus by Inducing Autophagy and Inhibiting Necroptosis. Am J Chin Med. 2017;45:557-573 pubmed publisher
    ..These original findings might provide an important basis for the further investigation of the therapeutic role of aucubin in treatment or prevention of epilepsy-related neuronal damages. ..
  92. Kang Z, Wu W, Wang J, Ouyang D. [Research advances in pharmacology of aucubin and aucubigenin]. Zhongguo Zhong Yao Za Zhi. 2007;32:2585-7 pubmed