momordica charantia

Summary

Summary: A plant species of the family CUCURBITACEAE. It is a source of ribosome-inactivating proteins and triterpene glycosides.

Top Publications

  1. Senanayake G, Maruyama M, Shibuya K, Sakono M, Fukuda N, Morishita T, et al. The effects of bitter melon (Momordica charantia) on serum and liver triglyceride levels in rats. J Ethnopharmacol. 2004;91:257-62 pubmed
    Effects of three different varieties (Koimidori, Powerful-Reishi, and Hyakunari) of bitter melon (Momordica charantia) and those of methanol fraction extract of Koimidori variety on serum and liver triglycerides were studied in rats...
  2. Abd El Sattar El Batran S, El Gengaihi S, El Shabrawy O. Some toxicological studies of Momordica charantia L. on albino rats in normal and alloxan diabetic rats. J Ethnopharmacol. 2006;108:236-42 pubmed
    b>Momordica charantia L. (MC) (Cucurbitaceae) commonly known as balsam pear, bitter gourd or karela, used in several purposes in traditional medicine is an important medicinal plant...
  3. Basch E, Gabardi S, Ulbricht C. Bitter melon (Momordica charantia): a review of efficacy and safety. Am J Health Syst Pharm. 2003;60:356-9 pubmed
    ..Bitter melon (Momordica charantia) is an alternative therapy that has primarily been used for lowering blood glucose levels in patients with ..
  4. Raza H, Ahmed I, John A. Tissue specific expression and immunohistochemical localization of glutathione S-transferase in streptozotocin induced diabetic rats: modulation by Momordica charantia (karela) extract. Life Sci. 2004;74:1503-11 pubmed
    ..In addition, we have also shown that treatment with an extract of Momordica charantia (karela), an antidiabetic herb, modulates GST expression in diabetic rats and reverts them to the normal ..
  5. Sathishsekar D, Subramanian S. Beneficial effects of Momordica charantia seeds in the treatment of STZ-induced diabetes in experimental rats. Biol Pharm Bull. 2005;28:978-83 pubmed
    ..the effect of the aqueous extract of seeds of two varieties, namely a country and hybrid variety of Momordica charantia (MCSEt1 and MCSEt2) on oxidative stress in plasma and pancreas of streptozotocin (STZ) induced diabetic ..
  6. Tripathi U, Chandra D. The plant extracts of Momordica charantia and Trigonella foenum-graecum have anti-oxidant and anti-hyperglycemic properties for cardiac tissue during diabetes mellitus. Oxid Med Cell Longev. 2009;2:290-6 pubmed publisher
    ..The present study was aimed to investigate the effect of Momordica charantia (MC) and Trigonella foenum graecum (TFG) extracts (aqueous) on antioxidant status and lipid peroxidation in ..
  7. Wang Z, Zhang X, Yu Y, Poulev A, Ribnicky D, Floyd Z, et al. Bioactives from bitter melon enhance insulin signaling and modulate acyl carnitine content in skeletal muscle in high-fat diet-fed mice. J Nutr Biochem. 2011;22:1064-73 pubmed publisher
    ..Nutritional supplementation with this extract, if validated for human studies, may offer an adjunctive therapy for diabetes. ..
  8. Huang H, Hong Y, Wong Y, Chen Y, Chyuan J, Huang C, et al. Bitter melon (Momordica charantia L.) inhibits adipocyte hypertrophy and down regulates lipogenic gene expression in adipose tissue of diet-induced obese rats. Br J Nutr. 2008;99:230-9 pubmed
    Bitter melon (Momordica charantia; BM) has been shown to ameliorate diet-induced obesity and insulin resistance...
  9. Telang M, Srinivasan A, Patankar A, Harsulkar A, Joshi V, Damle A, et al. Bitter gourd proteinase inhibitors: potential growth inhibitors of Helicoverpa armigera and Spodoptera litura. Phytochemistry. 2003;63:643-52 pubmed
    Proteinase inhibitors (PIs) from the seeds of bitter gourd (Momordica charantia L.) were identified as strong inhibitors of Helicoverpa armigera gut proteinases (HGP)...

More Information

Publications86

  1. Yin J, Zhang H, Ye J. Traditional chinese medicine in treatment of metabolic syndrome. Endocr Metab Immune Disord Drug Targets. 2008;8:99-111 pubmed
    ..Bitter melon or bitter gourd (Momordica charantia) is able to reduce blood glucose and lipids in both normal and diabetic animals...
  2. Ojewole J, Adewole S, Olayiwola G. Hypoglycaemic and hypotensive effects of Momordica charantia Linn (Cucurbitaceae) whole-plant aqueous extract in rats. Cardiovasc J S Afr. 2006;17:227-32 pubmed
    Various morphological parts (roots, stems, leaves and fruits) of Momordica charantia Linn (family: Cucurbitaceae) are used traditionally in African folk medicine to manage, control and/or treat a plethora of human ailments, including ..
  3. Gadang V, Gilbert W, Hettiararchchy N, Horax R, KATWA L, Devareddy L. Dietary bitter melon seed increases peroxisome proliferator-activated receptor-? gene expression in adipose tissue, down-regulates the nuclear factor-?B expression, and alleviates the symptoms associated with metabolic syndrome. J Med Food. 2011;14:86-93 pubmed publisher
    ..To our knowledge, this study for the first time shows that BMS exerts cardioprotective effects by down-regulating the NF-?B inflammatory pathway. ..
  4. Nerurkar P, Lee Y, Motosue M, Adeli K, Nerurkar V. Momordica charantia (bitter melon) reduces plasma apolipoprotein B-100 and increases hepatic insulin receptor substrate and phosphoinositide-3 kinase interactions. Br J Nutr. 2008;100:751-9 pubmed publisher
    Aqueous extracts or juice from unripened fruit of Momordica charantia (bitter melon) has traditionally been used in the treatment of diabetes and its complications...
  5. Pitchakarn P, Ogawa K, Suzuki S, Takahashi S, Asamoto M, Chewonarin T, et al. Momordica charantia leaf extract suppresses rat prostate cancer progression in vitro and in vivo. Cancer Sci. 2010;101:2234-40 pubmed publisher
    ..Any compounds with an inhibitory influence on this process are therefore of prime interest. Momordica charantia (bitter melon) is widely consumed as a vegetable and especially as a folk medicine in Asia...
  6. Akhtar S, Khan A, Husain Q. Potential of immobilized bitter gourd (Momordica charantia) peroxidases in the decolorization and removal of textile dyes from polluted wastewater and dyeing effluent. Chemosphere. 2005;60:291-301 pubmed
    Immobilized peroxidases from Momordica charantia were highly effective in decolorizing reactive textile dyes compared to its soluble counterpart...
  7. Ma J, Whittaker P, Keller A, Mazzola E, Pawar R, White K, et al. Cucurbitane-type triterpenoids from Momordica charantia. Planta Med. 2010;76:1758-61 pubmed publisher
    ..5), and kuguaglycoside G (6), were isolated from the whole plant of Momordica charantia. Their structures were determined by chemical and spectroscopic methods...
  8. Dans A, Villarruz M, Jimeno C, Javelosa M, Chua J, Bautista R, et al. The effect of Momordica charantia capsule preparation on glycemic control in type 2 diabetes mellitus needs further studies. J Clin Epidemiol. 2007;60:554-9 pubmed
    b>Momordica charantia, locally known as Ampalaya, is being widely used and advertised for its hypoglycemic effects. However, to date, no large clinical trial has been published on the efficacy of any type of preparation...
  9. Tabata K, Hamano A, Akihisa T, Suzuki T. Kuguaglycoside C, a constituent of Momordica charantia, induces caspase-independent cell death of neuroblastoma cells. Cancer Sci. 2012;103:2153-8 pubmed publisher
    Kuguaglycoside C is a triterpene glycoside isolated from the leaves of Momordica charantia, and the biological effects of this compound remain almost unknown...
  10. Lo H, Ho T, Lin C, Li C, Hsiang C. Momordica charantia and its novel polypeptide regulate glucose homeostasis in mice via binding to insulin receptor. J Agric Food Chem. 2013;61:2461-8 pubmed publisher
    b>Momordica charantia (MC) has been used as an alternative therapy for diabetes mellitus...
  11. Chao C, Huang C. Bitter gourd (Momordica charantia) extract activates peroxisome proliferator-activated receptors and upregulates the expression of the acyl CoA oxidase gene in H4IIEC3 hepatoma cells. J Biomed Sci. 2003;10:782-91 pubmed
    ..It was found that the EA extract of bitter gourd (Momordica charantia), a common oriental vegetable, activated PPARalpha to an extent that was equivalent to or even higher than ..
  12. Tripathi U, Chandra D. Anti-hyperglycemic and anti-oxidative effect of aqueous extract of Momordica charantia pulp and Trigonella foenum graecum seed in alloxan-induced diabetic rats. Indian J Biochem Biophys. 2010;47:227-33 pubmed
    ..b>Momordica charantia (family: Cucurbitaceae) and Trigonella foenum graecum (family: Fabaceae) are used traditionally in Indian ..
  13. Akhtar S, Husain Q. Potential applications of immobilized bitter gourd (Momordica charantia) peroxidase in the removal of phenols from polluted water. Chemosphere. 2006;65:1228-35 pubmed
    ..The soluble bitter gourd peroxidase ceased to function after 3h while the immobilized enzyme was active even after 6h of incubation with phenolic solutions. ..
  14. Chaturvedi P. Role of Momordica charantia in maintaining the normal levels of lipids and glucose in diabetic rats fed a high-fat and low-carbohydrate diet. Br J Biomed Sci. 2005;62:124-6 pubmed
    This study aims to assess whether or not a methanol extract of Momordica charantia is able to normalise lipid and glucose levels in diabetic rats fed a high-fat and a low-carbohydrate diet...
  15. Kumar R, Balaji S, Uma T, Sehgal P. Fruit extracts of Momordica charantia potentiate glucose uptake and up-regulate Glut-4, PPAR gamma and PI3K. J Ethnopharmacol. 2009;126:533-7 pubmed publisher
    b>Momordica charantia fruit is a widely used traditional medicinal herb as, anti-diabetic, anti-HIV, anti-ulcer, anti-inflammatory, anti-leukemic, anti-microbial, and anti-tumor...
  16. Fernandes N, Lagishetty C, Panda V, Naik S. An experimental evaluation of the antidiabetic and antilipidemic properties of a standardized Momordica charantia fruit extract. BMC Complement Altern Med. 2007;7:29 pubmed
    The MCE, Momordica charantia fruit extract Linn. (Cucurbitaceae) have been documented to elicit hypoglycemic activity on various occasions. However, due to lack of standardization of these extracts, their efficacy remains questionable...
  17. Tuan P, Kim J, Lee S, Chae S, Park S. Riboflavin accumulation and characterization of cDNAs encoding lumazine synthase and riboflavin synthase in bitter melon (Momordica charantia). J Agric Food Chem. 2012;60:11980-6 pubmed publisher
    ..which catalyze the last two steps in the riboflavin biosynthetic pathway, were cloned from bitter melon (Momordica charantia), a popular vegetable crop in Asia...
  18. Sasa M, Inoue I, Shinoda Y, Takahashi S, Seo M, Komoda T, et al. Activating effect of momordin, extract of bitter melon (Momordica Charantia L.), on the promoter of human PPARdelta. J Atheroscler Thromb. 2009;16:888-92 pubmed
    Bitter melon (Momordica charantia L.) is a common vegetable grown in Okinawa that has also been used recently in medicine for the treatment of diseases such as diabetes, hypertension, and dyslipidemia...
  19. Mwambete K. The in vitro antimicrobial activity of fruit and leaf crude extracts of Momordica charantia: a Tanzania medicinal plant. Afr Health Sci. 2009;9:34-9 pubmed
    To evaluate the antimicrobial activity of Momordica charantia extracts on reference strains and microorganisms isolated from clinical specimens...
  20. Cahoon E, Dietrich C, Meyer K, Damude H, Dyer J, Kinney A. Conjugated fatty acids accumulate to high levels in phospholipids of metabolically engineered soybean and Arabidopsis seeds. Phytochemistry. 2006;67:1166-76 pubmed
    Expression of Delta(12)-oleic acid desaturase-related fatty acid conjugases from Calendula officinalis, Momordica charantia, and Vernicia fordii in seeds of soybean (Glycine max) or an Arabidopsis thaliana fad3/fae1 mutant was ..
  21. Ahmed I, Adeghate E, Cummings E, Sharma A, Singh J. Beneficial effects and mechanism of action of Momordica charantia juice in the treatment of streptozotocin-induced diabetes mellitus in rat. Mol Cell Biochem. 2004;261:63-70 pubmed
    This study investigated the beneficial effects and mechanism of action of the juice of Momordica charantia in streptozotocin (STZ)-induced diabetes mellitus in rats. Diabetes mellitus was associated with significant (p < 0...
  22. Sheng Q, Yao H, Xu H, Ling X, He T. [Isolation of plant insulin from Momordica charantia seeds by gel filtration and RP-HPLC]. Zhong Yao Cai. 2004;27:414-6 pubmed
    Hypoglycemic polypeptide (PA) was extracted from Momordica charantia seeds with organic acid and ethanol and purified with Sephadex G-50 gel filtration and RP-HPLC...
  23. Nerurkar P, Johns L, Buesa L, Kipyakwai G, Volper E, Sato R, et al. Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation. J Neuroinflammation. 2011;8:64 pubmed publisher
    ..The objective of our study was to investigate the neuroprotective effects of Momordica charantia (bitter melon) on high-fat diet (HFD)-associated BBB disruption, stress and neuroinflammatory cytokines.
  24. Rathi S, Grover J, Vats V. The effect of Momordica charantia and Mucuna pruriens in experimental diabetes and their effect on key metabolic enzymes involved in carbohydrate metabolism. Phytother Res. 2002;16:236-43 pubmed
    The Indian traditional system of medicine prescribed traditional plant therapies. Two such plants, i.e. Momordica charantia (MC) and Mucuna pruriens (MP), earlier shown to reduce hyperglycaemia, were assessed for their anti ..
  25. Hsu C, Tsai T, Li Y, Wu W, Huang C, Tsai P. Wild bitter melon (Momordica charantia Linn. var. abbreviata Ser.) extract and its bioactive components suppress Propionibacterium acnes-induced inflammation. Food Chem. 2012;135:976-84 pubmed publisher
    In this study, we aimed to evaluate the inhibitory effect of wild bitter melons (WBM; Momordica charantia Linn. var. abbreviata Ser.) on Propionibacterium acnes-induced inflammation and to identify the bioactive components...
  26. Liu J, Chen J, Wang C, Qiu M. New cucurbitane triterpenoids and steroidal glycoside from Momordica charantia. Molecules. 2009;14:4804-13 pubmed publisher
    ..triterpenoids 1-3 and one new steroidal glycoside 4, were isolated together with ten known compounds from Momordica charantia. The structures of new compounds were determined to be 19(R)-n-butanoxy-5 beta,19-epoxycucurbita-6,23-diene-..
  27. Fang E, Ng T. Bitter gourd (Momordica charantia) is a cornucopia of health: a review of its credited antidiabetic, anti-HIV, and antitumor properties. Curr Mol Med. 2011;11:417-36 pubmed
    Bitter gourd (Momordica charantia, BG) is both a nutritious and healthy food with a distinctive bitter flavor, and it is also widely exploited in folklore medicine...
  28. Nerurkar P, Ray R. Bitter melon: antagonist to cancer. Pharm Res. 2010;27:1049-53 pubmed publisher
    ..For centuries, Ayurveda (Indian traditional medicine) has recommended the use of bitter melon (Momordica charantia) as a functional food to prevent and treat diabetes and associated complications...
  29. Huang L, Adachi T, Shimizu Y, Goto Y, Toyama J, Tanaka H, et al. Characterization of lectin isolated from Momordica charantia seed as a B cell activator. Immunol Lett. 2008;121:148-56 pubmed publisher
    Lectin isolated from the seeds of Momordica charantia (MCL) is a galactose-specific glycoprotein...
  30. Meng Y, Liu S, Li J, Meng Y, Zhao X. Preparation of an antitumor and antivirus agent: chemical modification of ?-MMC and MAP30 from Momordica Charantia L. with covalent conjugation of polyethyelene glycol. Int J Nanomedicine. 2012;7:3133-42 pubmed publisher
    Alpha-momorcharin (?-MMC) and momordica anti-HIV protein (MAP30) derived from Momordica charantia L. have been confirmed to possess antitumor and antivirus activities due to their RNA-N-glycosidase activity...
  31. Snee L, Nerurkar V, Dooley D, Efird J, Shovic A, Nerurkar P. Strategies to improve palatability and increase consumption intentions for Momordica charantia (bitter melon): a vegetable commonly used for diabetes management. Nutr J. 2011;10:78 pubmed publisher
    ..b>Momordica charantia, commonly known as bitter melon has been traditionally used in Ayurvedic and Chinese medicine to treat ..
  32. Miura T, Itoh Y, Iwamoto N, Kato M, Ishida T. Suppressive activity of the fruit of Momordica charantia with exercise on blood glucose in type 2 diabetic mice. Biol Pharm Bull. 2004;27:248-50 pubmed
    The antidiabetic activity of Momordica charantia L. (Cucurbitaceae) with exercise was investigated in KK-Ay mice, an animal model with type 2 diabetes with hyperinsulinemia. The water extract of the fruit of Momordica charantia L...
  33. Kumar G, Shetty A, Salimath P. Modulatory effect of bitter gourd (Momordica charantia LINN.) on alterations in kidney heparan sulfate in streptozotocin-induced diabetic rats. J Ethnopharmacol. 2008;115:276-83 pubmed
    ..These results clearly indicate beneficial role of bitter gourd in controlling glycoconjugate and heparan sulfate related kidney complications during diabetes thus prolonging late complications of diabetes...
  34. Ahmad Z, Zamhuri K, Yaacob A, Siong C, Selvarajah M, Ismail A, et al. In vitro anti-diabetic activities and chemical analysis of polypeptide-k and oil isolated from seeds of Momordica charantia (bitter gourd). Molecules. 2012;17:9631-40 pubmed publisher
    The amino acid and fatty acid composition of polypeptide k and oil isolated from the seeds of Momordica charantia was analysed...
  35. Piskin A, Altunkaynak B, Tümentemur G, Kaplan S, Yazıcı O, Hokelek M. The beneficial effects of Momordica charantia (bitter gourd) on wound healing of rabbit skin. J Dermatolog Treat. 2014;25:350-7 pubmed publisher
    b>Momordica charantia (MC; bitter gourd) is a traditional herbal commonly used for its antidiabetic, antioxidant, contraceptive and antibacterial properties...
  36. Cummings E, Hundal H, Wackerhage H, Hope M, Belle M, Adeghate E, et al. Momordica charantia fruit juice stimulates glucose and amino acid uptakes in L6 myotubes. Mol Cell Biochem. 2004;261:99-104 pubmed
    The fruit of Momordica charantia (family: Cucurbitacea) is used widely as a hypoglycaemic agent to treat diabetes mellitus (DM). The mechanism of the hypoglycaemic action of M. charantia in vitro is not fully understood...
  37. Pitchakarn P, Suzuki S, Ogawa K, Pompimon W, Takahashi S, Asamoto M, et al. Induction of G1 arrest and apoptosis in androgen-dependent human prostate cancer by Kuguacin J, a triterpenoid from Momordica charantia leaf. Cancer Lett. 2011;306:142-50 pubmed publisher
    In this study, we focused on the effects of a bitter melon (Momordica charantia) leaf extract (BMLE) and a purified component, Kuguacin J (KuJ), on androgen-dependent LNCaP human prostate cancer cells...
  38. Keller A, Ma J, Kavalier A, He K, Brillantes A, Kennelly E. Saponins from the traditional medicinal plant Momordica charantia stimulate insulin secretion in vitro. Phytomedicine. 2011;19:32-7 pubmed publisher
    The antidiabetic activity of Momordica charantia (L.), Cucurbitaceae, a widely-used treatment for diabetes in a number of traditional medicine systems, was investigated in vitro...
  39. Inayat ur Rahman -, Malik S, Bashir M, Khan R, Iqbal M. Serum sialic acid changes in non-insulin-dependant diabetes mellitus (NIDDM) patients following bitter melon (Momordica charantia) and rosiglitazone (Avandia) treatment. Phytomedicine. 2009;16:401-5 pubmed publisher
  40. Shetty A, Kumar G, Sambaiah K, Salimath P. Effect of bitter gourd (Momordica charantia) on glycaemic status in streptozotocin induced diabetic rats. Plant Foods Hum Nutr. 2005;60:109-12 pubmed
    Bitter gourd (Momordica charantia), a commonly consumed vegetable is used as an adjunct in the management of diabetes mellitus...
  41. Nerurkar P, Lee Y, Nerurkar V. Momordica charantia (bitter melon) inhibits primary human adipocyte differentiation by modulating adipogenic genes. BMC Complement Altern Med. 2010;10:34 pubmed publisher
    ..b>Momordica charantia or bitter melon (BM) that is traditionally used to treat diabetes and complications has been demonstrated ..
  42. Roffey B, Atwal A, Johns T, Kubow S. Water extracts from Momordica charantia increase glucose uptake and adiponectin secretion in 3T3-L1 adipose cells. J Ethnopharmacol. 2007;112:77-84 pubmed
    To examine the effects of Momordica charantia on glucose uptake and adiponectin secretion in adipose cells, 3T3-L1 adipocytes were treated with three concentrations (0.2, 0.3 and 0...
  43. Yadav U, Moorthy K, Baquer N. Combined treatment of sodium orthovanadate and Momordica charantia fruit extract prevents alterations in lipid profile and lipogenic enzymes in alloxan diabetic rats. Mol Cell Biochem. 2005;268:111-20 pubmed
    b>Momordica charantia Linn., commonly called bitter gourd, is a medicinal plant used in the Ayurvedic system of medicine for treating various diseases including diabetes mellitus...
  44. Harinantenaina L, Tanaka M, Takaoka S, Oda M, Mogami O, Uchida M, et al. Momordica charantia constituents and antidiabetic screening of the isolated major compounds. Chem Pharm Bull (Tokyo). 2006;54:1017-21 pubmed
    Bioguided fractionation of the methanol extract of Momordica charantia dried gourds led to the isolation of three new cucurbitane triterpenoids (1-3), together with eight known compounds (4-11)...
  45. Fang E, Zhang C, Wong J, Shen J, Li C, Ng T. The MAP30 protein from bitter gourd (Momordica charantia) seeds promotes apoptosis in liver cancer cells in vitro and in vivo. Cancer Lett. 2012;324:66-74 pubmed publisher
    ..used as in vitro and in vivo models to assess the efficacy and safety of MAP30, a natural component from Momordica charantia, as an anticancer agent against liver cancer...
  46. Tsai T, Chu L, Lee C, Pan T. Atherosclerosis-preventing activity of lactic acid bacteria-fermented milk-soymilk supplemented with Momordica charantia. J Agric Food Chem. 2009;57:2065-71 pubmed publisher
    In this study, the milk-soymilk and milk-soymilk supplemented with Momordica charantia , a common oriental vegetable possessing medicinal activities, were fermented by lactic bacteria...
  47. Brennan V, Wang C, Yang W. Bitter melon (Momordica charantia) extract suppresses adrenocortical cancer cell proliferation through modulation of the apoptotic pathway, steroidogenesis, and insulin-like growth factor type 1 receptor/RAC-? serine/threonine-protein kinase signalin. J Med Food. 2012;15:325-34 pubmed publisher
    ..Taken together, these data illustrate the inhibitory effect of bitter melon on cell proliferation of adrenocortical cancer through modulation of diverse mechanisms...
  48. Fang E, Zhang C, Fong W, Ng T. RNase MC2: a new Momordica charantia ribonuclease that induces apoptosis in breast cancer cells associated with activation of MAPKs and induction of caspase pathways. Apoptosis. 2012;17:377-87 pubmed publisher
    ..purification and characterization of a 14-kDa RNase, designated as RNase MC2, in the seeds of bitter gourd (Momordica charantia)...
  49. Cheng H, Huang H, Chang C, Tsai C, Chou C. A cell-based screening identifies compounds from the stem of Momordica charantia that overcome insulin resistance and activate AMP-activated protein kinase. J Agric Food Chem. 2008;56:6835-43 pubmed publisher
    ..The crude extracts from all parts of Momordica charantia L. have been reported by many studies for the effective treatment of diabetes and related complications...
  50. Chuang C, Hsu C, Chao C, Wein Y, Kuo Y, Huang C. Fractionation and identification of 9c, 11t, 13t-conjugated linolenic acid as an activator of PPARalpha in bitter gourd (Momordica charantia L.). J Biomed Sci. 2006;13:763-72 pubmed
    Bitter gourd (Momordica charantia L.) is a common vegetable in Asia that has been used in traditional medicine for the treatment of Diabetes...
  51. Chan L, Chen Q, Go A, Lam E, Li E. Reduced adiposity in bitter melon (Momordica charantia)-fed rats is associated with increased lipid oxidative enzyme activities and uncoupling protein expression. J Nutr. 2005;135:2517-23 pubmed
    ..05). The present results suggest that decreased adiposity in BM-supplemented rats may result from lower metabolic efficiency, a consequence of increased lipid oxidation and mitochondrial uncoupling. ..
  52. Uebanso T, Arai H, Taketani Y, Fukaya M, Yamamoto H, Mizuno A, et al. Extracts of Momordica charantia suppress postprandial hyperglycemia in rats. J Nutr Sci Vitaminol (Tokyo). 2007;53:482-8 pubmed
    b>Momordica charantia (bitter melon) is commonly known as vegetable insulin, but the mechanisms underlying its hypoglycemic effect remain unclear...
  53. Kasbia G, Arnason J, Imbeault P. No effect of acute, single dose oral administration of Momordica charantia Linn., on glycemia, energy expenditure and appetite: a pilot study in non-diabetic overweight men. J Ethnopharmacol. 2009;126:127-33 pubmed publisher
    b>Momordica charantia Linn. Cucurbitaceae (MC), has been used to treat glycemic impairment in humans for centuries...
  54. Malik Z, Singh M, Sharma P. Neuroprotective effect of Momordica charantia in global cerebral ischemia and reperfusion induced neuronal damage in diabetic mice. J Ethnopharmacol. 2011;133:729-34 pubmed publisher
    b>Momordica charantia L. (Cucurbitaceae) fruits have been used traditionally for centuries, especially for treating diabetes and associated complications.
  55. Yang P, Li X, Shipp M, Shockey J, Cahoon E. Mining the bitter melon (momordica charantia l.) seed transcriptome by 454 analysis of non-normalized and normalized cDNA populations for conjugated fatty acid metabolism-related genes. BMC Plant Biol. 2010;10:250 pubmed publisher
    Seeds of Momordica charantia (bitter melon) produce high levels of eleostearic acid, an unusual conjugated fatty acid with industrial value...
  56. Shih C, Lin C, Lin W, Wu J. Momordica charantia extract on insulin resistance and the skeletal muscle GLUT4 protein in fructose-fed rats. J Ethnopharmacol. 2009;123:82-90 pubmed publisher
    We investigated the preventive effect of Momordica charantia Linn. (Cucurbitaceae) fruit, commonly known as bitter melon, on hyperglycemia and insulin resistance in rats fed with a fructose-enriched diet.
  57. Singh N, Gupta M, Sirohi P, Varsha -. Effects of alcoholic extract of Momordica charantia (Linn.) whole fruit powder on the pancreatic islets of alloxan diabetic albino rats. J Environ Biol. 2008;29:101-6 pubmed
    Alcoholic extract of whole fruit of Momordica charantia was prepared. Adult healthy albino rats were divided into four groups and received a dose of 6 mg/l00 gm. body weight of alloxan monohydrate...
  58. Chang C, Chen C, Liao Y, Cheng H, Chen Y, Chou C. Cucurbitane-type triterpenoids from the stems of momordica charantia. J Nat Prod. 2008;71:1327-30 pubmed publisher
    ..7), and 25-methoxy-3beta,7beta-dihydroxycucurbita-5,23(E)-dien-19-al (8), were isolated from the methyl alcohol extract of the stems of Momordica charantia. The structures of the new compounds were elucidated by spectroscopic methods.
  59. Cheng H, Kuo C, Liao Y, Lin C. EMCD, a hypoglycemic triterpene isolated from Momordica charantia wild variant, attenuates TNF-?-induced inflammation in FL83B cells in an AMP-activated protein kinase-independent manner. Eur J Pharmacol. 2012;689:241-8 pubmed publisher
    ..b>Momordica charantia, also known as bitter melon, has been used as an herbal medicine and reported to ameliorate inflammation ..
  60. Horax R, Hettiarachchy N, Chen P. Extraction, quantification, and antioxidant activities of phenolics from pericarp and seeds of bitter melons (Momordica charantia) harvested at three maturity stages (immature, mature, and ripe). J Agric Food Chem. 2010;58:4428-33 pubmed publisher
    Bitter melon (Momordica charantia) is an exotic vegetable used for consumption and medicinal purposes mainly throughout Asia...
  61. Sathishsekar D, Subramanian S. Antioxidant properties of Momordica Charantia (bitter gourd) seeds on Streptozotocin induced diabetic rats. Asia Pac J Clin Nutr. 2005;14:153-8 pubmed
    ..activities of the aqueous extract of seeds of two varieties, namely a country and hybrid variety of Momordica charantia (MCSEt1 and MCSEt2) respectively in streptozotocin induced diabetic rats...
  62. Raj S, Khan M, Singh R, Kumari N, Prakash D. Occurrence of yellow mosaic geminiviral disease on bitter gourd (Momordica charantia) and its impact on phytochemical contents. Int J Food Sci Nutr. 2005;56:185-92 pubmed
    Natural occurrence of yellow mosaic disease was observed on bitter gourd (Momordica charantia)...
  63. Chaturvedi P, George S. Momordica charantia maintains normal glucose levels and lipid profiles and prevents oxidative stress in diabetic rats subjected to chronic sucrose load. J Med Food. 2010;13:520-7 pubmed publisher
    b>Momordica charantia L., commonly known as bitter gourd, is used as a vegetable by the Asian community in Africa. It is frequently used as an antidiabetic herb for the management of the disease in the Ayurvedic system of medicine...
  64. Alam S, Asad M, Asdaq S, Prasad V. Antiulcer activity of methanolic extract of Momordica charantia L. in rats. J Ethnopharmacol. 2009;123:464-9 pubmed publisher
    b>Momordica charantia L. (Cucurbitaceae) commonly known as 'bitter gourd' is a multi purpose herb cultivated in different parts of the world for its edible fruits...
  65. Kenny O, Smyth T, Hewage C, Brunton N. Antioxidant properties and quantitative UPLC-MS analysis of phenolic compounds from extracts of fenugreek (Trigonella foenum-graecum) seeds and bitter melon (Momordica charantia) fruit. Food Chem. 2013;141:4295-302 pubmed publisher
    Freeze-dried fenugreek (Trigonella foenum-graecum) seeds and bitter melon (Momordica charantia) fruit were extracted sequentially using non-polar to polar solvents, with further separation carried out on polar extracts by molecular ..
  66. Pitchakarn P, Ohnuma S, Pintha K, Pompimon W, Ambudkar S, Limtrakul P. Kuguacin J isolated from Momordica charantia leaves inhibits P-glycoprotein (ABCB1)-mediated multidrug resistance. J Nutr Biochem. 2012;23:76-84 pubmed publisher
    ..Our previous study showed that bitter melon (Momordica charantia) leaf extract (BMLE) was able to reverse the MDR phenotype by increasing the intracellular accumulation of ..
  67. Shih C, Lin C, Lin W. Effects of Momordica charantia on insulin resistance and visceral obesity in mice on high-fat diet. Diabetes Res Clin Pract. 2008;81:134-43 pubmed publisher
    We examined the preventive effect of Momordica charantia L. fruit (bitter melon) on hyperglycemia and insulin resistance in C57BL/6J mice fed with a high-fat (HF) diet...
  68. Tan M, Ye J, Turner N, Hohnen Behrens C, Ke C, Tang C, et al. Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway. Chem Biol. 2008;15:263-73 pubmed publisher
    ..S, and T, and stereochemistry-established karaviloside XI, were isolated from the vegetable bitter melon (Momordica charantia)...
  69. Braca A, Siciliano T, D Arrigo M, Germanò M. Chemical composition and antimicrobial activity of Momordica charantia seed essential oil. Fitoterapia. 2008;79:123-5 pubmed publisher
    The essential oil obtained from the seeds of Momordica charantia was analyzed by GC/MS. Twenty-five components, representing 90.9% of the oil, were identified...
  70. Nagasawa H, Watanabe K, Inatomi H. Effects of bitter melon (Momordica charantia l.) or ginger rhizome (Zingiber offifinale rosc) on spontaneous mammary tumorigenesis in SHN mice. Am J Chin Med. 2002;30:195-205 pubmed
    The effects of chronic treatment with hot water extract of Bitter Melon (Momordica charantia L.) or Ginger Rhizome (Zingiber offifinale Rosc) on spontaneous mammary tumorigenesis were examined in SHN virgin mice...
  71. Hsu C, Hsieh C, Kuo Y, Huang C. Isolation and identification of cucurbitane-type triterpenoids with partial agonist/antagonist potential for estrogen receptors from Momordica charantia. J Agric Food Chem. 2011;59:4553-61 pubmed publisher
    ..investigating the estrogenic activity and active cucurbitane-type triterpenoid compounds of bitter gourd (Momordica charantia, MC) using a transactivation assay for estrogen receptors (ER) ? and ?...
  72. Leung L, Birtwhistle R, Kotecha J, Hannah S, Cuthbertson S. Anti-diabetic and hypoglycaemic effects of Momordica charantia (bitter melon): a mini review. Br J Nutr. 2009;102:1703-8 pubmed publisher
    ..b>Momordica charantia (bitter melon) is a popular fruit used for the treatment of diabetes and related conditions amongst the ..
  73. Teoh S, Latiff A, Das S. A histological study of the structural changes in the liver of streptozotocin-induced diabetic rats treated with or without Momordica charantia (bitter gourd). Clin Ter. 2009;160:283-6 pubmed
    ..The aim of the present study was to evaluate the histological changes following administration of Momordica charantia (MC) in the streptozotocin (STZ) induced diabetic rats.
  74. Limtrakul P, Khantamat O, Pintha K. Inhibition of P-glycoprotein activity and reversal of cancer multidrug resistance by Momordica charantia extract. Cancer Chemother Pharmacol. 2004;54:525-30 pubmed
    ..In this study, novel chemical modulator(s) from bitter melon (Momordica charantia L...
  75. Manabe M, Takenaka R, Nakasa T, Okinaka O. Induction of anti-inflammatory responses by dietary Momordica charantia L. (bitter gourd). Biosci Biotechnol Biochem. 2003;67:2512-7 pubmed
    We assessed the immunomodulatory activity of Momordica charantia L. (bitter gourd), a vegetable that has been reported to possess various bioactivities...
  76. Shih C, Shlau M, Lin C, Wu J. Momordica charantia ameliorates insulin resistance and dyslipidemia with altered hepatic glucose production and fatty acid synthesis and AMPK phosphorylation in high-fat-fed mice. Phytother Res. 2014;28:363-71 pubmed publisher
    b>Momordica charantia Linn. (Cucurbitaceae) fruit is commonly known as bitter melon...
  77. Sridhar M, Vinayagamoorthi R, Arul Suyambunathan V, Bobby Z, Selvaraj N. Bitter gourd (Momordica charantia) improves insulin sensitivity by increasing skeletal muscle insulin-stimulated IRS-1 tyrosine phosphorylation in high-fat-fed rats. Br J Nutr. 2008;99:806-12 pubmed