gynostemma

Summary

Summary: A plant genus of the family CUCURBITACEAE. It is a source of gypenosides and triterpenoid SAPONINS.

Top Publications

  1. Aktan F, Henness S, Roufogalis B, Ammit A. Gypenosides derived from Gynostemma pentaphyllum suppress NO synthesis in murine macrophages by inhibiting iNOS enzymatic activity and attenuating NF-kappaB-mediated iNOS protein expression. Nitric Oxide. 2003;8:235-42 pubmed
    Gypenosides isolated from Gynostemma pentaphyllum are widely used in traditional Chinese medicine, with beneficial effects reported in numerous diseases, including inflammation and atherosclerosis, although the mechanism underlying these ..
  2. Megalli S, Davies N, Roufogalis B. Anti-hyperlipidemic and hypoglycemic effects of Gynostemma pentaphyllum in the Zucker fatty rat. J Pharm Pharm Sci. 2006;9:281-91 pubmed
    b>Gynostemma pentaphyllum is a traditional Chinese medicine used for a variety of conditions, including elevated cholesterol...
  3. Li Q, Yao Z, Shi Y, Yao X, Ye W, Liu X. Determination of the three-dimensional structure of Gynoside A in solution using NMR and molecular modeling. Molecules. 2007;12:907-16 pubmed
    The three-dimensional structure of Gynoside A, an ocotillone-type triterpenoid glycoside isolated from Gynostemma pentaphyllum, was determined in pyridine-d5 and DMSO-d6 solution through constrained molecular modeling using constraints ..
  4. Zhang G, Zhao Z, Gao L, Deng J, Wang B, Xu D, et al. Gypenoside attenuates white matter lesions induced by chronic cerebral hypoperfusion in rats. Pharmacol Biochem Behav. 2011;99:42-51 pubmed publisher
    ..However, GP 200mg/kg per day had no significant effects. GP may have therapeutic potential for treating dementia induced by chronic cerebral hypoperfusion and further evaluation is warranted...
  5. Kao T, Huang S, Inbaraj B, Chen B. Determination of flavonoids and saponins in Gynostemma pentaphyllum (Thunb.) Makino by liquid chromatography-mass spectrometry. Anal Chim Acta. 2008;626:200-11 pubmed publisher
    b>Gynostemma pentaphyllum (Thunb.) Makino, a traditional Chinese herb possessing antitumor and antioxidant activities, has been shown to contain several functional components like saponins and flavonoids...
  6. Yeo J, Kang Y, Jeon S, Jung U, Lee M, Song H, et al. Potential hypoglycemic effect of an ethanol extract of Gynostemma pentaphyllum in C57BL/KsJ-db/db mice. J Med Food. 2008;11:709-16 pubmed publisher
    This study was conducted to evaluate the antihyperglycemic effect of an extract of Gynostemma pentaphyllum Makino, containing standardized concentrations of gypenosides, in C57BL/KSJ-db/db mice...
  7. Liou C, Huang W, Kuo M, Yang R, Shen J. Long-term oral administration of Gynostemma pentaphyllum extract attenuates airway inflammation and Th2 cell activities in ovalbumin-sensitized mice. Food Chem Toxicol. 2010;48:2592-8 pubmed publisher
    Our previous report demonstrated that the oral administration of short-term high dose Gynostemma pentaphyllum extract (5 g/kg per day for 7days) decreased allergic reactions in ovalbumin (OVA)-sensitized mice...
  8. Yang X, Zhao Y, Yang Y, Ruan Y. Isolation and characterization of immunostimulatory polysaccharide from an herb tea, Gynostemma pentaphyllum Makino. J Agric Food Chem. 2008;56:6905-9 pubmed publisher
    Water-soluble polysaccharide from Gynostemma pentaphyllum herb tea (PSGP) was isolated by hot-water extraction and ethanol precipitation...
  9. Megalli S, Aktan F, Davies N, Roufogalis B. Phytopreventative anti-hyperlipidemic effects of gynostemma pentaphyllum in rats. J Pharm Pharm Sci. 2005;8:507-15 pubmed
    b>Gynostemma pentaphyllum is widely used in traditional Chinese medicine. Preliminary studies indicate Gynostemma isolated triterpine glycosides lower cholesterol. Our studies examine anti-hyperlipidemic effects of gypenosides.

More Information

Publications88

  1. Zhu H, Liu Z, Tang L, Liu J, Zhou M, Xie F, et al. Reversal of P-gp and MRP1-mediated multidrug resistance by H6, a gypenoside aglycon from Gynostemma pentaphyllum, in vincristine-resistant human oral cancer (KB/VCR) cells. Eur J Pharmacol. 2012;696:43-53 pubmed publisher
    ..Here, we found that H6, a gypenoside aglycon from Gynostemma pentaphyllum, displayed potent anti-MDR activity. Average resistant fold (RF) of H6 is 1.03 and 1...
  2. Yuan H, Deng Y, Yuan L, Wu J, Yuan Z, Yi J, et al. Gynostemma pentaphyllum protects mouse male germ cells against apoptosis caused by zearalenone via Bax and Bcl-2 regulation. Toxicol Mech Methods. 2010;20:153-8 pubmed publisher
    The objective of this study was to explore the effects of Gynostemma pentaphyllum on Zearalenone-induced apoptosis in mouse male germ cells...
  3. Huang T, Razmovski Naumovski V, Salam N, Duke R, Tran V, Duke C, et al. A novel LXR-alpha activator identified from the natural product Gynostemma pentaphyllum. Biochem Pharmacol. 2005;70:1298-308 pubmed
    ..20-O-beta-d-glucopyranoside (TR1), a dammarane-type gynosaponin, isolated from the herbal medicine, Gynostemma pentaphyllum...
  4. Huyen V, Phan D, Thang P, Hoa N, Ostenson C. Antidiabetic effect of Gynostemma pentaphyllum tea in randomly assigned type 2 diabetic patients. Horm Metab Res. 2010;42:353-7 pubmed publisher
    The aim of the study was to investigate the antidiabetic effect of the traditional Vietnamese herb Gynostemma pentaphyllum in 24 drug-naïve type 2 diabetic patients...
  5. Choi H, Park M, Kim S, Hwang B, Lee C, Lee M. Neuroprotective effects of herbal ethanol extracts from Gynostemma pentaphyllum in the 6-hydroxydopamine-lesioned rat model of Parkinson's disease. Molecules. 2010;15:2814-24 pubmed publisher
    ..However, an oral administration of herbal ethanol extracts from Gynostemma pentaphyllum (GP-EX) (10 mg/kg and 30 mg/kg) starting on day 3 post-lesion for 28 days markedly ameliorated the ..
  6. Attawish A, Chivapat S, Phadungpat S, Bansiddhi J, Techadamrongsin Y, Mitrijit O, et al. Chronic toxicity of Gynostemma pentaphyllum. Fitoterapia. 2004;75:539-51 pubmed
    The effect of water extract of Gynostemma pentaphyllum was evaluated on 6-month chronic toxicity in Wistar rats. Control group received orally 10 ml kg(-1) day(-1)...
  7. Cheng T, Lu J, Wang J, Lin L, Kuo H, Chen B. Antiproliferation effect and apoptosis mechanism of prostate cancer cell PC-3 by flavonoids and saponins prepared from Gynostemma pentaphyllum. J Agric Food Chem. 2011;59:11319-29 pubmed publisher
    ..study were to investigate the antiproliferation and apoptosis mechanism of saponin and flavonoid fractions from Gynostemma pentaphyllum (Thunb.) Makino on prostate cancer cell PC-3...
  8. Tsai Y, Lin C, Chen B. Preparative chromatography of flavonoids and saponins in Gynostemma pentaphyllum and their antiproliferation effect on hepatoma cell. Phytomedicine. 2010;18:2-10 pubmed publisher
    A preparative column chromatographic method was developed to isolate flavonoids and saponins from Gynostemma pentaphyllum, a Chinese Medicinal herb, and evaluate their antiproliferation effect on hepatoma cell Hep3B, with the standards ..
  9. Li N, Wu C, Xu X, Liu Z, Li X, Zhao Y. Triterpenes possessing an unprecedented skeleton isolated from hydrolyzate of total saponins from Gynostemma pentaphyllum. Eur J Med Chem. 2012;50:173-8 pubmed publisher
    Five novel triterpenes were isolated from hydrolyzate of total saponins from Gynostemma pentaphyllum and identified as gypensapogenin A (1), gypensapogenin B (2), gypensapogenin C (3), 3-O-?-d-glucopyranosyl-gypensapogenin D (4) and ..
  10. Jiang L, Qian Z, Guo Z, Wang C, Zhao G. Polyploid origins in Gynostemma pentaphyllum (Cucurbitaceae) inferred from multiple gene sequences. Mol Phylogenet Evol. 2009;52:183-91 pubmed publisher
    The genus Gynostemma (Cucurbitaceae) constitutes a polyploid group of perennial creeping herbs, in whose evolution polyploidization is a key component. With the largest variety of cytotypes (2n=22, 44, 66 and 88) in Gynostemma, G...
  11. Subramaniyam S, Mathiyalagan R, Jun Gyo I, Bum Soo L, Sungyoung L, Deok Chun Y. Transcriptome profiling and insilico analysis of Gynostemma pentaphyllum using a next generation sequencer. Plant Cell Rep. 2011;30:2075-83 pubmed publisher
    Gynosaponins (Gypenosides) are major phyto-chemicals in Gynostemma pentaphyllum (Thunb.), with similarities to the ginsenosides present in Panax ginseng. Gynosaponins are classified as terpenoid compounds. In G...
  12. Huang W, Kuo M, Li M, Yang R, Liou C, Shen J. Gynostemma pentaphyllum decreases allergic reactions in a murine asthmatic model. Am J Chin Med. 2008;36:579-92 pubmed
    ..b>Gynostemma pentaphyllum (Thunb...
  13. Huang W, Kuo M, Li M, Yang R, Liou C, Shen J. Extract of Gynostemma pentaphyllum enhanced the production of antibodies and cytokines in mice. Yakugaku Zasshi. 2007;127:889-96 pubmed
    b>Gynostemma pentaphyllum is a popular herbal tea in China and some Asian countries. The modulatory function of G. pentaphyllum total plant extracts on immune cells was evaluated in this study...
  14. Norberg A, Hoa N, Liepinsh E, Van Phan D, Thuan N, Jornvall H, et al. A novel insulin-releasing substance, phanoside, from the plant Gynostemma pentaphyllum. J Biol Chem. 2004;279:41361-7 pubmed
    Extracts from Gynostemma pentaphyllum Makino (Cucurbitaceae), a Southeast Asian herb, has been reported to affect numerous activities resulting in antitumor, cholesterol-lowering, immunopotentiating, antioxidant, and hypoglycemic effects...
  15. Chou S, Chen K, Hwang J, Lu W, Chu Y, Lin J, et al. The add-on effects of Gynostemma pentaphyllum on nonalcoholic fatty liver disease. Altern Ther Health Med. 2006;12:34-9 pubmed
    ..Other than weight reduction by dieting or physical activity, there are no well-documented medical treatments for fatty liver disease...
  16. Xu J, Shen Q, Li J, Hu L. Dammaranes from Gynostemma pentaphyllum and synthesis of their derivatives as inhibitors of protein tyrosine phosphatase 1B. Bioorg Med Chem. 2010;18:3934-9 pubmed publisher
    ..27microM), where 3-O-meta-carboxylphenyl substituted 5a exhibited the best selectivity (nearly fivefolds) between PTP1B and T-cell protein tyrosine phosphatase...
  17. Chiranthanut N, Teekachunhatean S, Panthong A, Khonsung P, Kanjanapothi D, Lertprasertsuk N. Toxicity evaluation of standardized extract of Gynostemma pentaphyllum Makino. J Ethnopharmacol. 2013;149:228-34 pubmed publisher
    To evaluate the safety of standardized extract of Gynostemma pentaphyllum in rats.
  18. Huang T, Li Y, Razmovski Naumovski V, Tran V, Li G, Duke C, et al. Gypenoside XLIX isolated from Gynostemma pentaphyllum inhibits nuclear factor-kappaB activation via a PPAR-alpha-dependent pathway. J Biomed Sci. 2006;13:535-48 pubmed
    ..b>Gynostemma pentaphyllum (GP) has been used to treat various inflammatory diseases and hyperlipidemia...
  19. Wang Q, Guo Q, Sun J, Zhang S, Li Y. [Studies on sex identification and variation of endogenous hormones in female and male plants of Gynostemma pentaphyllum]. Zhongguo Zhong Yao Za Zhi. 2004;29:837-40 pubmed
    To distinguish female and male plants of Gynostemma pentaphyllum quickly and accurately in the stage of seedling and to understand the relation between sex differentiation and endogenous plant hormone...
  20. Fan Y. [Study on preparation of gypenosides liposomes composed of sphingomyelin and cholesterol and its quality evaluation]. Zhongguo Zhong Yao Za Zhi. 2013;38:3875-9 pubmed
    ..It was feasible to prepare gypenosides liposome with sphingomyelin and cholesterol. The gypenosides liposomes prepared by the optimum preparation process were good in morphology, particle size and reproducibility. ..
  21. He F, Tian T, Wang G, Tang Q, Zhang J. [Effects of different factors on transformed hairy root in Gynostemm apentaphyllum]. Zhong Yao Cai. 2010;33:1675-7 pubmed
    ..8 for 10 min, 100 micromol/L As and MS + 300 mg/L Cab. Hairy roots were induced by co-cultivation and the optimum induced condition were determined. ..
  22. Lin J, Hsu H, Yang J, Lu K, Wu R, Wu K, et al. Molecular evidence of anti-leukemia activity of gypenosides on human myeloid leukemia HL-60 cells in vitro and in vivo using a HL-60 cells murine xenograft model. Phytomedicine. 2011;18:1075-85 pubmed publisher
    ..Oral consumption of Gyp reduced tumor size of HL-60 cell xenograft mode mice in vivo. These results provide new information on understanding mechanisms by which Gyp induces cell cycle arrest and apoptosis in vitro and in vivo. ..
  23. Han X, Wei H, Zhang F. Analysis of the inhibitory effect of gypenoside on Na(+), K (+)-ATPase in rats' heart and brain and its kinetics. Chin J Integr Med. 2007;13:128-31 pubmed
    ..Gyp displays its cardiotonic and central inhibitory effects by way of inhibiting heart and brain's microsomal Na(+), K(+)-ATPase activities in rats. ..
  24. Cai H, Liang Q, Ge G. Gypenoside Attenuates ? Amyloid-Induced Inflammation in N9 Microglial Cells via SOCS1 Signaling. Neural Plast. 2016;2016:6362707 pubmed publisher
    ..Gypenoside (GP) is the major bioactive constituent of Gynostemma pentaphyllum, a traditional Chinese herb medicine...
  25. Zhang Y, Zhang J, Xiao H, Wu P, Bai S. Gypenosides inhibit renal fibrosis by regulating expression of related genes in rats with unilateral ureteral obstruction. J Nephrol. 2011;24:112-8 pubmed
    ..GPs-mediated down-regulation of TGF-ß1 and CTGF and up-regulation of Smad7 are essential for their effects of antifibrogenesis. ..
  26. Xing S, Jang M, Wang Y, Piao X. A new dammarane-type saponin from Gynostemma pentaphyllum induces apoptosis in A549 human lung carcinoma cells. Bioorg Med Chem Lett. 2016;26:1754-9 pubmed publisher
    b>Gynostemma pentaphyllum has been widely used as a traditional herb for its antioxidant and immunostimulatory activities...
  27. Chen J, Lu K, Lee J, Yeh C, Chung J. Gypenosides induced apoptosis in human colon cancer cells through the mitochondria-dependent pathways and activation of caspase-3. Anticancer Res. 2006;26:4313-26 pubmed
    The effects of the gypenosides (Gyp), a component of Gynostemma pentaphyllum Makino, on the cell viability, cell cycle and induction of apoptosis were investigated in human colon cancer colo 205 cells...
  28. Guo H, Li R, Liu S, Zhao N, Han S, Lu M, et al. Molecular characterization, expression, and regulation of Gynostemma pentaphyllum squalene epoxidase gene 1. Plant Physiol Biochem. 2016;109:230-239 pubmed publisher
    b>Gynostemma pentaphyllum (Thunb.) Makino is a perennial medicinal herb widely distributed in China. This herb contains important medicinal components called gypenosides, which belong to dammarane-type triterpenoid saponins...
  29. Choi H, Zhao T, Shin K, Kim S, Hwang B, Lee C, et al. Anxiolytic effects of herbal ethanol extract from Gynostemma pentaphyllum in mice after exposure to chronic stress. Molecules. 2013;18:4342-56 pubmed publisher
    In this study, the effects of herbal ethanol extracts of Gynostemma pentaphyllum (GP-EX), on chronic electric footshock (EF) stress-induced anxiety disorders were investigated in mice, which were orally treated with GP-EX (30 mg/kg and 50 ..
  30. Lu K, Chen J, Lai T, Yang J, Weng S, Ma Y, et al. Gypenosides inhibits migration and invasion of human oral cancer SAS cells through the inhibition of matrix metalloproteinase-2 -9 and urokinase-plasminogen by ERK1/2 and NF-kappa B signaling pathways. Hum Exp Toxicol. 2011;30:406-15 pubmed publisher
    Gypenosides (Gyp), found in Gynostemma pentaphyllum Makino, has been used as a folk medicine in the Chinese population for centuries and is known to have diverse pharmacologic effects, including anti-proliferative and anti-cancer actions...
  31. Shi L, Lu F, Zhao H, Zhao Y. Two new triterpene saponins from Gynostemma pentaphyllum. J Asian Nat Prod Res. 2012;14:856-61 pubmed publisher
    Two new dammarane-type triterpene saponins, gypenbiosides A (1) and B (2), were isolated from the aerial parts of Gynostemma pentaphyllum (Thunb.) Makino...
  32. Jiang W, Shan H, Song J, Lu H. Separation and Purification of Ombuoside from Gynostemma Pentaphyllum by Microwave-Assisted Extraction Coupled with High-Speed Counter-current Chromatography. J Chromatogr Sci. 2017;55:69-74 pubmed
    A rapid and efficient method for the separation and purification of ombuoside from Gynostemma pentaphyllum by microwave-assisted extraction coupled with high-speed counter-current chromatography (HSCCC) was successfully developed...
  33. Lu K, Chen J, Lai T, Yang J, Weng S, Ma Y, et al. Gypenosides suppress growth of human oral cancer SAS cells in vitro and in a murine xenograft model: the role of apoptosis mediated by caspase-dependent and caspase-independent pathways. Integr Cancer Ther. 2012;11:129-40 pubmed publisher
    Gypenosides (Gyp) are the major components of Gynostemma pentaphyllum Makino...
  34. Zhang X, Zhao C, Tang W, Wu X, Zhao Y. Gypensapogenin H, a novel dammarane-type triterpene induces cell cycle arrest and apoptosis on prostate cancer cells. Steroids. 2015;104:276-83 pubmed publisher
    Gypensapogenin H (GH) is a novel dammarane-type triterpenes obtained from hydrolyzate of total saponins from Gynostemma pentaphyllum and its anti-tumor activity has been studied in previous work...
  35. Sun H, Zheng Q. Haemolytic activities and adjuvant effect of Gynostemma pentaphyllum saponins on the immune responses to ovalbumin in mice. Phytother Res. 2005;19:895-900 pubmed
    In this study, the haemolytic activities of Gynostemma pentaphyllum saponins (GPS) and its adjuvant potential on the immune responses of ICR mice against ovalbumin (OVA) were evaluated...
  36. Xiang W, Guo C, Ma L, Hu L. Dammarane-type glycosides and long chain sesquiterpene glycosides from Gynostemma yixingense. Fitoterapia. 2010;81:248-52 pubmed publisher
    ..Rg2 (8), 20(R)-ginsenoside Rg2 (9), ginsenoside Rd (10) and gypenoside XLVI (11) were isolated from Gynostemma yixingense...
  37. Kulwat C, Lertprasertsuke N, Leechanachai P, Kongtawelert P, Vinitketkumnuen U. Antimutagenicity and DT-diaphorase inducing activity of Gynostemma pentaphyllum Makino extract. J Med Invest. 2005;52:145-50 pubmed
    The hot water extract of the herbal tea, Gynostemma pentaphyllum Makino, was not found to be mutagenic in Salmonella mutation assay with or without metabolic activation...
  38. Schild L, Roth A, Keilhoff G, Gardemann A, Brödemann R. Protection of hippocampal slices against hypoxia/hypoglycemia injury by a Gynostemma pentaphyllum extract. Phytomedicine. 2009;16:734-43 pubmed publisher
    ..We report about a study investigating the effect of an ethanolic Gynostemma pentaphyllum extract in this system...
  39. Yin F, Zhang Y, Yang Z, Hu L. Nine new dammarane saponins from Gynostemma pentaphyllum. Chem Biodivers. 2006;3:771-82 pubmed
    Nine new dammarane saponins, 1-9, were isolated from the MeOH extract of the aerial part of Gynostemma pentaphyllum, an edible plant of the Cucurbitaceae family, that grows wildly in China...
  40. Zhang D, Zhang J, Wang J, Hu S, Li W, Ou L, et al. [Effects of Qilan Tangzhining capsule on glucose and lipid metabolism in rats with diabetes mellitus and hyperlipemia]. Zhongguo Zhong Yao Za Zhi. 2005;30:773-7 pubmed
    ..Qilan Tangzhining capsule can not only adjust the blood glucose and lipid, but also improve the histopathology injury of the liver and pancreas. ..
  41. Shi L, Cao J, Shi S, Zhao Y. Triterpenoid saponins from Gynostemma pentaphyllum. J Asian Nat Prod Res. 2011;13:168-77 pubmed publisher
    Four new dammarane-type triterpene saponins, 1-4, were isolated from the aerial parts of Gynostemma pentaphyllum (Thunb.) Makino...
  42. Chen J, Li X, Hu Y, Liu W, Zhou Q, Zhang H, et al. Gypenosides Ameliorate Carbon Tetrachloride-Induced Liver Fibrosis by Inhibiting the Differentiation of Hepatic Progenitor Cells into Myofibroblasts. Am J Chin Med. 2017;45:1061-1074 pubmed publisher
    Gypenosides (GPs), the predominant components of Gynostemma pentaphyllum, exert antifibrotic effects; however, the mechanisms underlying their ability to ameliorate liver fibrosis are unclear...
  43. Chen J, Lu K, Tsai M, Hsu S, Kuo C, Yang J, et al. Gypenosides induced G0/G1 arrest via CHk2 and apoptosis through endoplasmic reticulum stress and mitochondria-dependent pathways in human tongue cancer SCC-4 cells. Oral Oncol. 2009;45:273-83 pubmed publisher
    Gypenosides (Gyp), a component of Gynostemma pentaphyllum Makino, was selected for examining the effects on the cell viability, cell cycle and induction of apoptosis in human tongue cancer SCC-4 cells...
  44. Yang Y, Yang J, Jiang Q. Hypolipidemic effect of gypenosides in experimentally induced hypercholesterolemic rats. Lipids Health Dis. 2013;12:154 pubmed publisher
    ..The possible anti-hyperlipidemia mechanism maybe those GPs can regulate the disorder of lipid metabolism as well as ameliorate hepatic function. ..
  45. Piao X, Wu Q, Yang J, Park S, Chen D, Liu H. Dammarane-type saponins from heat-processed Gynostemma pentaphyllum show fortified activity against A549 cells. Arch Pharm Res. 2013;36:874-9 pubmed publisher
    An ethanol extract from heat-processed Gynostemma pentaphyllum showed more potent cytotoxic activity against human lung adenocarcinoma A549 cells than that of raw G. pentaphyllum. Four constituents were isolated from heat-processed G...
  46. Zheng K, Liao C, Li Y, Fan X, Fan L, Xu H, et al. Gypenoside L, Isolated from Gynostemma pentaphyllum, Induces Cytoplasmic Vacuolation Death in Hepatocellular Carcinoma Cells through Reactive-Oxygen-Species-Mediated Unfolded Protein Response. J Agric Food Chem. 2016;64:1702-11 pubmed publisher
    ..this study, we screened and identified an unexplored anticancer activity of gypenoside L (Gyp-L) isolated from Gynostemma pentaphyllum...
  47. Yang F, Shi H, Zhang X, Yang H, Zhou Q, Yu L. Two new saponins from tetraploid jiaogulan (Gynostemma pentaphyllum), and their anti-inflammatory and ?-glucosidase inhibitory activities. Food Chem. 2013;141:3606-13 pubmed publisher
    ..This study investigated the chemical components and health properties of a new jiaogulan genotype, tetraploid Gynostemma pentaphyllum...
  48. Chiu T, Chen J, Chen L, Lee J, Chung J. Gypenosides inhibited N-acetylation of 2-aminofluorene, N-acetyltransferase gene expression and DNA adduct formation in human cervix epithelioid carcinoma cells (HeLa). Res Commun Mol Pathol Pharmacol. 2004;115-116:157-74 pubmed
    ..Gypenosides are the major components of Gynostemma pentaphyllum Makino which had been used as a natural folk medicine in the Chinese populations...
  49. Feng Q, Li X, Peng J, Duan X, Fu Q, Hu Y. [Effect of gypenosides on DMN-induced liver fibrosis in rats]. Zhongguo Zhong Yao Za Zhi. 2012;37:505-8 pubmed
    ..To study the effect of gypenosides on DMN-induced liver fibrosis in rats...
  50. Chiu T, Chen J, Chung J. N-acetyltransferase is involved in gypenosides-induced N-acetylation of 2-aminofluorene and DNA adduct formation in human cervix epidermoid carcinoma cells (Ca Ski). In Vivo. 2003;17:281-8 pubmed
    ..The results demonstrated that gypenosides decreased the levels of AF-DNA adduct formation in these cells. The NAT PCR and cDNA microarray also demonstrated that gypenosides inhibited NAT mRNA expression in human cervix cancer cells...
  51. Xie Z, Zhao Y, Chen P, Jing P, Yue J, Yu L. Chromatographic fingerprint analysis and rutin and quercetin compositions in the leaf and whole-plant samples of di- and tetraploid Gynostemma pentaphyllum. J Agric Food Chem. 2011;59:3042-9 pubmed publisher
    b>Gynostemma pentaphyllum (Thunb.) Makino, also known as jiaogulan, has been shown to have antioxidant, antiproliferative, and anti-inflammatory activities. Flavonoid is considered a major contributor for these beneficial effects...
  52. Nookabkaew S, Rangkadilok N, Satayavivad J. Determination of trace elements in herbal tea products and their infusions consumed in Thailand. J Agric Food Chem. 2006;54:6939-44 pubmed
    ..Ni, Cu, Zn, Se, Sr, Sb, Ba, As, Cd, Hg, and Pb, were determined in three types of popular herbal tea products, Gynostemma pentaphyllum, Camellia sinensis, and Morus alba...
  53. Yin F, Zhang Y, Yang Z, Cheng Q, Hu L. Triterpene saponins from Gynostemma cardiospermum. J Nat Prod. 2006;69:1394-8 pubmed
    ..quercetin, and linalool 3-O-beta-D-glucopyranoside, were isolated from an ethanol extract of the aerial parts of Gynostemma cardiospermum...
  54. Yin F, Hu L, Pan R. Novel dammarane-type glycosides from Gynostemma pentaphyllum. Chem Pharm Bull (Tokyo). 2004;52:1440-4 pubmed
    ..gypenoside XLVIII (6), allantion (7) and vitexin (8) were isolated from the MeOH extract of the aerial parts of Gynostemma pentaphyllum. Compounds 5, 7, and 8 were isolated from this plant for the first time...
  55. Schild L, Chen B, Makarov P, Kattengell K, Heinitz K, Keilhoff G. Selective induction of apoptosis in glioma tumour cells by a Gynostemma pentaphyllum extract. Phytomedicine. 2010;17:589-97 pubmed publisher
    ..We report about a study investigating the effect of an ethanolic extract from Gynostemma pentaphyllum on proliferation of C6 glioma tumour cells and cellular H(2)O(2) concentration...
  56. Lu K, Chen J, Lai T, Yang J, Weng S, Ma Y, et al. Gypenosides causes DNA damage and inhibits expression of DNA repair genes of human oral cancer SAS cells. In Vivo. 2010;24:287-91 pubmed
    Gypenosides (Gyp) are the major components of Gynostemma pentaphyllum Makino, a Chinese medical plant. Recently, Gyp has been shown to induce cell cycle arrest and apoptosis in many human cancer cell lines...
  57. Quan Y, Qian M. [Effect and mechanism of gypenoside on the inflammatory molecular expression in high-fat induced atherosclerosis rats]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010;30:403-6 pubmed
    ..To evaluate the effect and possible mechanism of gypenoside (GP) on expression of inflammatory factors in aortic lesion of rats with high-fat induced atherosclerosis...
  58. Wang Q, Chiang C, Wu C, Cheng C, Hsieh S, Chen J, et al. Gypenosides induce apoptosis in human hepatoma Huh-7 cells through a calcium/reactive oxygen species-dependent mitochondrial pathway. Planta Med. 2007;73:535-44 pubmed
    ..Based on these results, we propose that the rise in intracellular Ca(2+) concentration plays a pivotal role in the initiation of gypenosides-triggered apoptotic death...
  59. Huang T, Bebawy M, Tran V, Roufogalis B. Specific reversal of multidrug resistance to colchicine in CEM/VLB(100) cells by Gynostemma pentaphyllum extract. Phytomedicine. 2007;14:830-9 pubmed
    ..The aim of this research is to study the role of gypenosides, isolated from Gynostemma pentaphyllum, as modulators of P-gp-mediated MDR in tumor cells, at both cellular and plasma membrane level...
  60. Lu J, Chen L, Xiao B, Wan W, Yu F, Tian Y. [Studies on the HPLC fingerprint spectrum of flavonoids in Gynostemma pentaphyllum]. Zhong Yao Cai. 2007;30:929-32 pubmed
    To establish the HPLC fingerprint spectrum of flavonoids from Gynostemma pentaphyllum.
  61. Zhang X, Bi X, Wan Xiao -, Cao J, Xia X, Diao Y, et al. Protein tyrosine phosphatase 1B inhibitory effect by dammarane-type triterpenes from hydrolyzate of total Gynostemma pentaphyllum saponins. Bioorg Med Chem Lett. 2013;23:297-300 pubmed publisher
    ..new together with twelve known triterpenes compounds) isolated from the hydrolyzate of total saponins from Gynostemma pentaphyllum...
  62. Muller C, Gardemann A, Keilhoff G, Peter D, Wiswedel I, Schild L. Prevention of free fatty acid-induced lipid accumulation, oxidative stress, and cell death in primary hepatocyte cultures by a Gynostemma pentaphyllum extract. Phytomedicine. 2012;19:395-401 pubmed publisher
    ..We used this cellular model to study the effect of an ethanolic Gynostemma pentaphyllum (GP) extract in NAFLD...
  63. Gauhar R, Hwang S, Jeong S, Kim J, Song H, Park D, et al. Heat-processed Gynostemma pentaphyllum extract improves obesity in ob/ob mice by activating AMP-activated protein kinase. Biotechnol Lett. 2012;34:1607-16 pubmed publisher
    b>Gynostemma pentaphyllum is widely used in Asian countries as a herbal medicine to treat dyslipidemia, type 2 diabetes and inflammation. An ethanol extract of G...
  64. Huang S, Hung C, Wu W, Chen B. Determination of chlorophylls and their derivatives in Gynostemma pentaphyllum Makino by liquid chromatography-mass spectrometry. J Pharm Biomed Anal. 2008;48:105-12 pubmed publisher
    ..chromatography-mass spectrometry (HPLC-MS) method for determination of chlorophylls and their derivatives in Gynostemma pentaphyllum Makino, a traditional Chinese herb possessing vital biological activities...
  65. Liang S, Sun H. [Determination of six nutritional elements in Chinese herbal medicines by graphite furnace atomic absorption spectrometry]. Guang Pu Xue Yu Guang Pu Fen Xi. 2002;22:847-9 pubmed
    ..Eucommiales, and Gynostemma pentaphyllum (Thunb.) Makino were studied...
  66. Ge M, Ma S, Tao L, Guan S. The effect of gypenosides on cardiac function and expression of cytoskeletal genes of myocardium in diabetic cardiomyopathy rats. Am J Chin Med. 2009;37:1059-68 pubmed
  67. Ky P, Huong P, My T, Anh P, Kiem P, Minh C, et al. Dammarane-type saponins from Gynostemma pentaphyllum. Phytochemistry. 2010;71:994-1001 pubmed publisher
    Dammarane-type saponins, gypenosides VN1-VN7 (1-7), were isolated from the total saponin extract of Gynostemma pentaphyllum aerial parts, with their structures elucidated on the basis of spectroscopic and chemical methods...
  68. Yin F, Hu L, Lou F, Pan R. Dammarane-type glycosides from Gynostemma pentaphyllum. J Nat Prod. 2004;67:942-52 pubmed
    ..compounds, gypenosides IV, VIII, LXXI, and XLIX, were isolated from the MeOH extract of the aerial parts of Gynostemma pentaphyllum...
  69. Chen T, Zhao T, Wei D, Wei Y, Li Y, Zhang H. Core-shell nanocarriers with ZnO quantum dots-conjugated Au nanoparticle for tumor-targeted drug delivery. Carbohydr Polym. 2013;92:1124-32 pubmed publisher
    ..copolymer contained poly(l-lactide) (PLA) inner arm and folate (FA)-conjugated a sulfated polysaccharide from Gynostemma pentaphyllum Makino (GPPS-FA) outer arm...
  70. Cheng L, Na J, Kim M, Bang M, Yang D. Microbial conversion of ginsenoside Rb1 to minor ginsenoside F2 and gypenoside XVII by Intrasporangium sp. GS603 isolated from soil. J Microbiol Biotechnol. 2007;17:1937-43 pubmed
    ..The culture broth of the strain GS603 could convert ginsenoside Rb(1 )into two metabolites, which were analyzed by TLC and HPLC and shown to be the minor ginsenoside F(2) and gypenoside XVII by NMR...
  71. Qin R, Zhang J, Li C, Zhang X, Xiong A, Huang F, et al. Protective effects of gypenosides against fatty liver disease induced by high fat and cholesterol diet and alcohol in rats. Arch Pharm Res. 2012;35:1241-50 pubmed publisher
    In the present study, the protective effects of gypenosides from Gynostemma pentaphyllum on fatty liver disease (FLD) were examined in rats treated with high fat and cholesterol diet and alcohol...
  72. Zhao T, Kim K, Shin K, Park H, Kim H, Lee K, et al. Gypenosides ameliorate memory deficits in MPTP-lesioned mouse model of Parkinson's disease treated with L-DOPA. BMC Complement Altern Med. 2017;17:449 pubmed publisher
    ..GPS may serve as an adjuvant therapeutic agent for memory deficits in patients with PD receiving L-DOPA. ..
  73. Kim J, Han Y. Dammarane-type saponins from Gynostemma pentaphyllum. Phytochemistry. 2011;72:1453-9 pubmed publisher
    ..gynosaponins TN-1, -2, and gymnemaside VI, were isolated from the methanol extract of the aerial parts of Gynostemma pentaphyllum. Their structures were elucidated by both analysis of 1D and 2D NMR spectra and chemical degradation...
  74. Liu X, Ye W, Mo Z, Yu B, Zhao S, Wu H, et al. Five new Ocotillone-type saponins from Gynostemma pentaphyllum. J Nat Prod. 2004;67:1147-51 pubmed
    ..gynosides A-E (1-5), along with 10 known dammarane-type saponins, were isolated from the aerial parts of Gynostemma pentaphyllum. The structures of these new compounds were determined by NMR analysis and acid hydrolysis...
  75. Wang C, Zhang Y, Yang J, Jiang L, Li M, Zhao G. [Identification of Gynostemma from their adulterant Cayratia japonica by PCR-RFLP]. Zhongguo Zhong Yao Za Zhi. 2008;33:2167-70 pubmed
    To establish a convenient and effective method for the identification of Gynostemma and Cayratia japonica.
  76. Shi L, Meng X, Cao J, Zhao Y. A new triterpenoid saponin from Gynostemma pentaphyllum. Nat Prod Res. 2012;26:1419-22 pubmed publisher
    A new dammarane-type triterpene saponin was isolated from the aerial parts of Gynostemma pentaphyllum (Thunb.) Makino...
  77. Niu Y, Yan W, Lv J, Yao W, Yu L. Characterization of a novel polysaccharide from tetraploid Gynostemma pentaphyllum makino. J Agric Food Chem. 2013;61:4882-9 pubmed publisher
    A novel heteropolysaccharide (GPP-TL) was isolated from tetraploid Gynostemma pentaphyllum (Makino) leaf by hot water extraction and anion-exchange and gel permeation chromatography approaches. GPP-TL had a molecular weight of 9...
  78. He M, Jiang J, Qiu F, Liu S, Peng P, Gao C, et al. Inhibitory effects of gypenosides on seven human cytochrome P450 enzymes in vitro. Food Chem Toxicol. 2013;57:262-5 pubmed publisher
    ..52 ?g/mL, respectively. Gypenosides exhibited competitive inhibition of CYP2D6 (Ki=1.18). In conclusion, Gypenosides might cause herb-drug interactions via inhibition of CYP2D6. An in vivo study is needed to examine this further...
  79. Malek M, Hoang M, Jia Y, Lee J, Jun H, Lee D, et al. Ombuin-3-O-?-D-glucopyranoside from Gynostemma pentaphyllum is a dual agonistic ligand of peroxisome proliferator-activated receptors ? and ?/?. Biochem Biophys Res Commun. 2013;430:1322-8 pubmed publisher
    We demonstrated that ombuin-3-O-?-D-glucopyranoside (ombuine), a flavonoid from Gynostemma pentaphyllum, is a dual agonist for peroxisome proliferator-activated receptors (PPARs) ? and ?/?...