buxus

Summary

Summary: A plant genus of the family BUXACEAE. Members contain steroidal alkaloids.

Top Publications

  1. Ait Mohamed O, Battisti V, Joliot V, Fritsch L, Pontis J, Medjkane S, et al. Acetonic extract of Buxus sempervirens induces cell cycle arrest, apoptosis and autophagy in breast cancer cells. PLoS ONE. 2011;6:e24537 pubmed publisher
    ..Here, we investigated the cytotoxic activity of the acetonic extract of Buxus sempervirens on five breast cancer cell lines, MCF7, MCF10CA1a and T47D, three aggressive triple positive breast ..
  2. Matochko W, James A, Lam C, Kozera D, Ata A, Gengan R. Triterpenoidal alkaloids from Buxus natalensis and their acetylcholinesterase inhibitory activity. J Nat Prod. 2010;73:1858-62 pubmed publisher
    Acetylcholinesterase (AChE) inhibition-directed phytochemical studies on the methanolic extract of Buxus natalensis, collected in South Africa, resulted in the isolation of 12 compounds: O(2)-natafuranamine (1), O(10)-natafuranamine (2), ..
  3. Mesaik M, Halim S, Ul Haq Z, Choudhary M, Shahnaz S, Ayatollahi S, et al. Immunosuppressive activity of buxidin and E-buxenone from Buxus hyrcana. Chem Biol Drug Des. 2010;75:310-7 pubmed publisher
    Buxidin (1) and E-Buxenone (2), steroidal alkaloids from Buxus hyrcana, are found to possess potent immunosuppressive properties...
  4. Ata A, Iverson C, Kalhari K, Akhter S, Betteridge J, Meshkatalsadat M, et al. Triterpenoidal alkaloids from Buxus hyrcana and their enzyme inhibitory, anti-fungal and anti-leishmanial activities. Phytochemistry. 2010;71:1780-6 pubmed publisher
    From the aerial parts of Buxus hyrcana, three triterpenoidal alkaloids, 17-oxo-3-benzoylbuxadine (1), buxhyrcamine (2), and 31-demethylcyclobuxoviridine (3), along with 16 known compounds, cyclobuxoviridine (4), N(b)-..
  5. Hormaetxe K, Becerril J, Hernandez A, Esteban R, García Plazaola J. Plasticity of photoprotective mechanisms of Buxus sempervirens L. leaves in response to extreme temperatures. Plant Biol (Stuttg). 2007;9:59-68 pubmed
    ..to generate photooxidative stress, we analysed photoprotective responses in leaves of the evergreen boxtree (Buxus sempervirens L.) during summer 2003...
  6. Yan Y, Hu X, Chen J, Sun Y, Zhang X, Qing C, et al. Cytotoxic triterpenoid alkaloids from Buxus microphylla. J Nat Prod. 2009;72:308-11 pubmed publisher
    ..alkaloids, buxmicrophyllines E-I (1-5), and six known ones (6-11) were isolated from the leaves and stems of Buxus microphylla...
  7. Babar Z, Ata A, Meshkatalsadat M. New bioactive steroidal alkaloids from Buxus hyrcana. Steroids. 2006;71:1045-51 pubmed
    Phytochemical studies on the crude methanolic extract of Buxus hyrcana, collected from Iran, resulted in the isolation of two new steroidal alkaloids, (+)-O6-buxafurandiene (1) and (+)-7-deoxy-O6-buxafurandiene (2) along with four known ..
  8. Hansen D, Dastidar S, Cai Z, Penaflor C, Kuehl J, Boore J, et al. Phylogenetic and evolutionary implications of complete chloroplast genome sequences of four early-diverging angiosperms: Buxus (Buxaceae), Chloranthus (Chloranthaceae), Dioscorea (Dioscoreaceae), and Illicium (Schisandraceae). Mol Phylogenet Evol. 2007;45:547-63 pubmed
    We have determined the complete chloroplast genome sequences of four early-diverging lineages of angiosperms, Buxus (Buxaceae), Chloranthus (Chloranthaceae), Dioscorea (Dioscoreaceae), and Illicium (Schisandraceae), to examine the ..
  9. Rosselló J, Lazaro A, Cosín R, Molins A. A phylogeographic split in Buxus balearica (Buxaceae) as evidenced by nuclear ribosomal markers: when ITS paralogues are welcome. J Mol Evol. 2007;64:143-57 pubmed
    ..b>Buxus balearica was chosen as a model species to assess the levels of infraspecific and intragenomic ITS variation in ..

More Information

Publications47

  1. Wu J, Tan Z, Chen J, Dong C. Cyclovirobuxine D Inhibits Cell Proliferation and Induces Mitochondria-Mediated Apoptosis in Human Gastric Cancer Cells. Molecules. 2015;20:20659-68 pubmed publisher
    ..Cyclovirobuxine D (CVB-D) is the main active component of the traditional Chinese medicine Buxus microphylla...
  2. Arabuli T, Cobanoglu S, Auger P. Panonychus from Georgia: survey, taxonomical status and redescription of P. hadzhibejliae (Reck, 1947) (Acari, Tetranychidae). Zootaxa. 2016;4114:464-76 pubmed publisher
    ..New hosts for P. ulmi and P. citri are recorded, Buxus sempervirens, Hedera colchica and Prunus laurocerasus for P. ulmi and Ficus carica for P. citri, whereas P...
  3. Aranguren B, Revedin A, Amico N, Cavulli F, Giachi G, Grimaldi S, et al. Wooden tools and fire technology in the early Neanderthal site of Poggetti Vecchi (Italy). Proc Natl Acad Sci U S A. 2018;115:2054-2059 pubmed publisher
    ..2017) Quat Res 88:327-344]. The sticks, all fragmentary, are made from boxwood (Buxus sempervirens) and were over 1 m long, rounded at one end and pointed at the other...
  4. Casals P, Rios A. Burning intensity and low light availability reduce resprouting ability and vigor of Buxus sempervirens L. after clearing. Sci Total Environ. 2018;627:403-416 pubmed publisher
    ..This study focuses on Buxus sempervirens, a slow-growing, multi-stemmed tree species, frequently dominant in the understory of temperate ..
  5. Sun Y, Moore M, Zhang S, Soltis P, Soltis D, Zhao T, et al. Phylogenomic and structural analyses of 18 complete plastomes across nearly all families of early-diverging eudicots, including an angiosperm-wide analysis of IR gene content evolution. Mol Phylogenet Evol. 2016;96:93-101 pubmed publisher
    ..somniferum (Papaveraceae), and compared them to previously published plastomes of the early-diverging eudicots Buxus, Tetracentron, Trochodendron, Nelumbo, Platanus, Nandina, Megaleranthis, Ranunculus, Mahonia and Macadamia...
  6. Bai S, Zhu G, Peng X, Dong J, Yu M, Chen J, et al. Cytotoxicity of Triterpenoid Alkaloids from Buxus microphylla against Human Tumor Cell Lines. Molecules. 2016;21: pubmed publisher
    Three new triterpenoid alkaloids, namely buxmicrophyllines P-R (1-3), were isolated from the twigs and leaves of Buxus microphylla. Their structures were elucidated on the basis of NMR and MS spectroscopic analyses...
  7. Yang T, Groenewald J, Cheewangkoon R, Jami F, Abdollahzadeh J, Lombard L, et al. Families, genera, and species of Botryosphaeriales. Fungal Biol. 2017;121:322-346 pubmed publisher
    ..sterculiae (Sterculia oblonga, Germany), Neofusicoccum pistaciarum (Pistacia vera, USA), N. buxi (Buxus sempervirens, France), N...
  8. Dehghan H, Sarrafi Y, Salehi P. Antioxidant and antidiabetic activities of 11 herbal plants from Hyrcania region, Iran. J Food Drug Anal. 2016;24:179-188 pubmed publisher
    ..total phenolic contents of n-hexane, ethyl acetate, and methanol extracts of various parts of Allium paradoxum, Buxus hyrcana, Convolvulus persicus, Eryngium caucasicum, Heracleum persicum, Pimpinella affinis, Parrotia persica, ..
  9. Vettraino A, Li H, Eschen R, Morales Rodriguez C, Vannini A. The sentinel tree nursery as an early warning system for pathway risk assessment: Fungal pathogens associated with Chinese woody plants commonly shipped to Europe. PLoS ONE. 2017;12:e0188800 pubmed publisher
    ..fortunae, Zelkova schneideriana, Fraxinus chinensis and Buxus microphylla...
  10. Ajebli M, Eddouks M. Buxus sempervirens L Improves Streptozotocin-induced Diabetes Mellitus in Rats. Cardiovasc Hematol Disord Drug Targets. 2017;17:142-152 pubmed publisher
    b>Buxus sempervirens L. (Boxwood) is a medicinal plant used in Moroccan traditional medicine for diabetes treatment in Morocco. However; there is no experimental support of this ethnopharmacological use.
  11. Yu H, Liu H, Zhou G. [Effect of cyclovirobuxinum-D on cerebral ischemia-reperfusion injury in rats]. Zhongguo Zhong Yao Za Zhi. 2007;32:623-6 pubmed
    ..To observe the effect of cyclovirobuxinum-D (CVB-D) on cerebral ischemia-reperfusion injury in rats and explore its mechanisms...
  12. Dai Z, Liang J, Su X, Xu Q, Zhang H. [Study on the constituents of petroleum ether fraction of Buxus microphylla]. Zhong Yao Cai. 2009;32:1062-4 pubmed
    To study the chemical constituents from the petroleum ether fraction of Buxus microphylla.
  13. Khan A, Ali S, Gilani A, Ahmed M, Choudhary M. Antispasmodic, bronchodilator, vasorelaxant and cardiosuppressant effects of Buxus papillosa. BMC Complement Altern Med. 2017;17:54 pubmed publisher
    The present research was carried out to investigate pharmacological properties of Buxus papillosa C.K. Schneid. (Buxaceae)...
  14. Li L, Zhou X, Liu G, Zhang L, Ou Q, Hao J. [Infrared spectroscopic study on leaf senescence of evergreen tree]. Guang Pu Xue Yu Guang Pu Fen Xi. 2013;33:340-3 pubmed
    ..This study demonstrates the potential of mid-infrared spectroscopy for investigation of plants senescence, as well as physiological and biochemical changes of plants...
  15. Yu B, Fang T, Lü G, Xu H, Lu J. Beneficial effect of Cyclovirobuxine D on heart failure rats following myocardial infarction. Fitoterapia. 2011;82:868-77 pubmed publisher
    The effect of Cyclovirobuxine D, an active ingredient from Buxus microphylla, was investigated in the potential prevention of cardiac dysfunction in rats with congestive heart failure...
  16. Szczepaniec A, Raupp M. Direct and indirect effects of imidacloprid on fecundity and abundance of Eurytetranychus buxi (Acari: Tetranychidae) on boxwoods. Exp Appl Acarol. 2013;59:307-18 pubmed publisher
    ..on fecundity and longevity of Eurytetranychus buxi Garman (Acari: Tetranychidae), feeding on boxwoods, Buxus sempervirens L. Moreover, we compared the abundance of E...
  17. Lazaro A, Mendez M. Variation in sexual expression in the monoecious shrub Buxus balearica at different scales. Plant Biol (Stuttg). 2007;9:736-44 pubmed
    ..We studied variation in sexual expression and its correlates in the monoecious shrub Buxus balearica, for two years, in six populations in the Balearic Islands and four in the Iberian Peninsula...
  18. Deng L, Huang H, Xu M, Zhou S, Wang X, Lu M, et al. [Structural modification and bioactivity of cyclovirobuxine D]. Yao Xue Xue Bao. 2004;39:434-8 pubmed
    ..To search for new compounds for the treatment of cardiovascular diseases by structural modification of cyclovirobuxine D...
  19. Kim D, Zhang H, Zhou H, Du T, Wu Q, Mockler T, et al. Highly sensitive image-derived indices of water-stressed plants using hyperspectral imaging in SWIR and histogram analysis. Sci Rep. 2015;5:15919 pubmed publisher
    ..The identified image-derived indices 15XX?nm/14XX nm (i.e. 1529?nm/1416?nm) were superior to common vegetation indices, such as WBI, MSI, and NDWI, with significantly better sensitivity, enabling early diagnostics of plant health. ..
  20. Yu B, Ruan M, Shen X, Xu L, Zheng H, Fang T. [Effects of CVB-D on hemodynamic in anaesthetized dogs in vivo]. Zhong Yao Cai. 2011;34:1741-5 pubmed
    ..To investigate hemodynamic in anaesthetized dogs after the intravenous injection of cyclovirobuxine D (CVB-D)...
  21. Hormaetxe K, Becerril J, Fleck I, Pinto M, García Plazaola J. Functional role of red (retro)-carotenoids as passive light filters in the leaves of Buxus sempervirens L.: increased protection of photosynthetic tissues?. J Exp Bot. 2005;56:2629-36 pubmed
    Red (retro)-carotenoids accumulate in chloroplasts of Buxus sempervirens leaves during the process of winter leaf acclimation...
  22. Deng L, Huang H, Xu M, Zhou S, Ren F, Wang X, et al. [Prodrug structural modifications of cyclovirobuxine D and their biological activity]. Yao Xue Xue Bao. 2005;40:820-4 pubmed
  23. Chen Y, Fan X, Gong Q. [Determination of cyclovirobuxine-D in huangyangning tablets by RP-HPLC with gradient elution]. Zhongguo Zhong Yao Za Zhi. 2006;31:1155-7 pubmed
    ..To establish a new method for the determination of cyclovirobuxine-D in huangyangning tablets...
  24. Orhan I, Khan M, Erdem S, Kartal M, Sener B. Selective cholinesterase inhibitors from Buxus sempervirens L. and their molecular docking studies. Curr Comput Aided Drug Des. 2011;7:276-86 pubmed
    In this work, two alkaloids namely (+)-buxabenzamidienine (1) and (+)-buxamidine (2) were isolated from Buxus sempervirens, using bioassay-guided fractionation and isolation method...
  25. Musharraf S, Goher M, Shahnaz S, Choudhary M, Atta Ur Rahman -. Structure-fragmentation relationship and rapid dereplication of Buxus steroidal alkaloids by electrospray ionization-quadrupole time-of-flight mass spectrometry. Rapid Commun Mass Spectrom. 2013;27:169-78 pubmed publisher
    ..The knowledge of the collision-induced dissociation (CID) fragmentation pattern of the molecule is essentially required prior to the analysis by LC/MS/MS...
  26. Choudhary M, Shahnaz S, Parveen S, Khalid A, Mesaik M, Ayatollahi S. New cholinesterase-inhibiting triterpenoid alkaloids from Buxus hyrcana. Chem Biodivers. 2006;3:1039-52 pubmed
    The current phytochemical investigation on Buxus hyrcana Pojark. has resulted in the isolation of the triterpenoid alkaloids 1-10...
  27. Bernal M, Llorens L, Julkunen Tiitto R, Badosa J, Verdaguer D. Altitudinal and seasonal changes of phenolic compounds in Buxus sempervirens leaves and cuticles. Plant Physiol Biochem. 2013;70:471-82 pubmed publisher
    ..we aimed to investigate: a) whether the seasonal and altitudinal changes in the content of phenolic compounds of Buxus sempervirens L...
  28. Liu H, Ji M, Cai J. Short and efficient approach towards buxozine-C, an alkaloid from Buxus sempervirens. Arch Pharm (Weinheim). 2006;339:675-6 pubmed
    b>Buxus alkaloids display a wide range of interesting pharmacological activities. Here, we present a short and efficient approach towards one of the alkaloids, buxozine-C...
  29. Hormaetxe K, Hernandez A, Becerril J, García Plazaola J. Role of red carotenoids in photoprotection during winter acclimation in Buxus sempervirens leaves. Plant Biol (Stuttg). 2004;6:325-32 pubmed
    ..The present study shows that the leaves of common box ( Buxus sempervirens L...
  30. Choudhary M, Shahnaz S, Parveen S, Khalid A, Majeed Ayatollahi S, Atta Ur Rahman -, et al. New triterpenoid alkaloid cholinesterase inhibitors from Buxus hyrcana. J Nat Prod. 2003;66:739-42 pubmed
    ..3), have been isolated from the leaf extracts of Buxus hyrcana collected in Iran. Their structures were determined using spectroscopic methods...
  31. Zhou J, Sun Y, Tan Y, Deng S, Huang G. [The effect of cyclovirobuxinum D on myocardial ischemia induced by coronary artery ligation in rats]. Zhong Yao Cai. 2007;30:828-30 pubmed
    ..To study the cardiac protection of Cyclovirobuxinum D (Cvb-D) in rats model...
  32. Ebrahimzadeh M, Nabavi S, Nabavi S, Bahramian F, Bekhradnia A. Antioxidant and free radical scavenging activity of H. officinalis L. var. angustifolius, V. odorata, B. hyrcana and C. speciosum. Pak J Pharm Sci. 2010;23:29-34 pubmed
    ..The content of total phenolic compounds and flavonoids were measured in plant extracts. The data obtained in the in vitro models clearly establish the antioxidant potency of all extracts...
  33. Deng L, Huang H, Xu M. [Structural modification of cyclovirobuxine D and their inhibition activity on lipid peroxidation]. Yao Xue Xue Bao. 2006;41:121-4 pubmed
    ..To search for compounds through structural modification of cyclovirobuxine D, using 20 or 21-aminosteroids as lead compound for the treatment of cerebrovascular diseases with better lipid peroxidation inhibitory activity...
  34. Silva Cancino M, Esteban R, Artetxe U, Plazaola J. Patterns of spatio-temporal distribution of winter chronic photoinhibition in leaves of three evergreen Mediterranean species with contrasting acclimation responses. Physiol Plant. 2012;144:289-301 pubmed publisher
    ..Three species (Buxus sempervirens, Cistus albidus and Arctostaphylos uva-ursi) with contrasting responses to winter stress were studied...
  35. Yan Y, Chen J, Sun Y, Wang Y, Su J, Li Y, et al. Triterpenoid alkaloids from Buxus microphylla. Chem Biodivers. 2010;7:1822-7 pubmed publisher
    ..together with four analogues, 3-6, were isolated from the leaves and stems of Buxus microphylla. The structures of the new compounds were elucidated by NMR and MS spectroscopic analyses...
  36. Mongélard G, Seemann M, Boisson A, Rohmer M, Bligny R, Rivasseau C. Measurement of carbon flux through the MEP pathway for isoprenoid synthesis by (31)P-NMR spectroscopy after specific inhibition of 2-C-methyl-d-erythritol 2,4-cyclodiphosphate reductase. Effect of light and temperature. Plant Cell Environ. 2011;34:1241-7 pubmed publisher
    ..was determined in spinach (Spinacia oleracea), pea (Pisum sativum), Oregon grape (Mahonia aquifolium) and boxwood (Buxus sempervirens) leaves. In spinach, flux values were compared with the synthesis rate of major isoprenoids...
  37. Chen Q, Shan H, Sun H, Wang H, Yang B. [Effects of cyclovirobuxine D on intracellular Ca2+ and L-type Ca2+ current in rat ventricular cardiomyocytes]. Yao Xue Xue Bao. 2004;39:500-3 pubmed
    ..To determine the effects of cyclovirobuxine D (CD) on intracellular Ca2+ mobilization and L-type Ca2+ current (I(Ca-L)) in isolated rat cardiomyocytes...
  38. Xu X, Zhang Z, Sheng L, Liu G, An D. [Determination of cyclovirobuxine D by RP-HPLC with precolumn fluorescence derivatization]. Yao Xue Xue Bao. 2002;37:359-61 pubmed
    ..To establish a RP-HPLC method for determination of cyclovirobuxine D...