boswellia

Summary

Summary: A plant genus of the family BURSERACEAE used medicinally since ancient times. It is a source of salai guggal (the gum resin), boswellic acid (ursane type TRITERPENES), and FRANKINCENSE.

Top Publications

  1. Kiela P, Midura A, Kuscuoglu N, Jolad S, Solyom A, Besselsen D, et al. Effects of Boswellia serrata in mouse models of chemically induced colitis. Am J Physiol Gastrointest Liver Physiol. 2005;288:G798-808 pubmed
    Extracts from Boswellia serrata have been reported to have anti-inflammatory activity, primarily via boswellic acid-mediated inhibition of leukotriene synthesis...
  2. Pandey R, Singh B, Tripathi Y. Extract of gum resins of Boswellia serrata L. inhibits lipopolysaccharide induced nitric oxide production in rat macrophages along with hypolipidemic property. Indian J Exp Biol. 2005;43:509-16 pubmed
    b>Boswellia serrata, Linn F (Burseraceae) is commonly used in Indian system of medicine (Ayurvedic) as an anti-inflammatory, analgesic, anti-arthritic and anti-proliferative agent...
  3. Frank A, Unger M. Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction. J Chromatogr A. 2006;1112:255-62 pubmed
    ..remedies with inhibitory activity on cytochrome P450 (CYP) enzymes, we identified extracts of the gum-resin of Boswellia carteri, Boswellia frereana, Boswellia sacra and Boswellia serrata as equally potent, non-selective inhibitors ..
  4. Akihisa T, Tabata K, Banno N, Tokuda H, Nishimura R, Nishihara R, et al. Cancer chemopreventive effects and cytotoxic activities of the triterpene acids from the resin of Boswellia carteri. Biol Pharm Bull. 2006;29:1976-9 pubmed
    ..12-14, 16), and two cembrane-type diterpenes (17, 18), isolated from the MeOH extract of the resin of Boswellia carteri (Burseraceae), together with a triterpene acid 15 (the acetyl derivative of 14), were examined for their ..
  5. Camarda L, Dayton T, Di Stefano V, Pitonzo R, Schillaci D. Chemical composition and antimicrobial activity of some oleogum resin essential oils from Boswellia spp. (Burseraceae). Ann Chim. 2007;97:837-44 pubmed
    The chemical composition of Boswellia carteri (Somalia), B. papyrifera (Ethiopia), B. serrata (India) and B. rivae (Ethiopia) oleogum resin essential oils was investigated using GC-MS to identify chemotaxonomy marker components...
  6. Lakshmi Niranjan Reddy V, Ravinder K, Srinivasulu M, Venkateshwar Goud T, Malla Reddy S, Srujankumar D, et al. Two new macrocyclic diaryl ether heptanoids from Boswellia ovalifoliolata. Chem Pharm Bull (Tokyo). 2003;51:1081-4 pubmed
    The stems of Boswellia ovalifoliolata BAL...
  7. Al Harrasi A, Al Saidi S. Phytochemical analysis of the essential oil from botanically certified oleogum resin of Boswellia sacra (Omani Luban). Molecules. 2008;13:2181-9 pubmed
    The yield of hydrodistillation of a botanically certified Oleogum Resin of Boswellia sacra essential oil (5.5%); and its chemical constituents were determined. The GC/MS technique was used for the analysis of the oil...
  8. Alokail M, Alarifi S. Histological changes in the lung of Wistar albino rats (Rattus norvegicus) after exposure to Arabian incense (genus Boswellia). Ann Saudi Med. 2004;24:293-5 pubmed
  9. Park Y, Lee J, Bondar J, Harwalkar J, Safayhi H, Golubic M. Cytotoxic action of acetyl-11-keto-beta-boswellic acid (AKBA) on meningioma cells. Planta Med. 2002;68:397-401 pubmed
    ..acid (AKBA) is a naturally occurring pentacyclic triterpene isolated from the gum resin exudate of the tree Boswellia serrata (frankincense)...

More Information

Publications68

  1. Flavin D. A lipoxygenase inhibitor in breast cancer brain metastases. J Neurooncol. 2007;82:91-3 pubmed
    ..b>Boswellia serrata, a lipoxygenase inhibitor was applied for this inhibition...
  2. Holtmeier W, Zeuzem S, Preiss J, Kruis W, Böhm S, Maaser C, et al. Randomized, placebo-controlled, double-blind trial of Boswellia serrata in maintaining remission of Crohn's disease: good safety profile but lack of efficacy. Inflamm Bowel Dis. 2011;17:573-82 pubmed publisher
    ..The aim of this study was to evaluate the efficacy and safety of long-term therapy with a new Boswellia serrata extract (Boswelan, PS0201Bo) in maintaining remission in patients with Crohn's disease (CD)...
  3. Hartmann R, Morgan Martins M, Tieppo J, Fillmann H, Marroni N. Effect of Boswellia serrata on antioxidant status in an experimental model of colitis rats induced by acetic acid. Dig Dis Sci. 2012;57:2038-44 pubmed publisher
    To evaluate the antioxidant effect of an extract of the plant Boswellia serrata in an experimental model of acute ulcerative colitis induced by administration of acetic acid (AA) in rats.
  4. Badria F, Mikhaeil B, Maatooq G, Amer M. Immunomodulatory triterpenoids from the oleogum resin of Boswellia carterii Birdwood. Z Naturforsch C. 2003;58:505-16 pubmed
    The immunomodulatory bioassay-guided fractionation of the oleogum resin of frankincense (Boswellia carterii Birdwood) resulted in the isolation and identification of 9 compounds; palmitic acid and eight triterpenoids belonging to lupane, ..
  5. Mothana R. Anti-inflammatory, antinociceptive and antioxidant activities of the endemic Soqotraen Boswellia elongata Balf. f. and Jatropha unicostata Balf. f. in different experimental models. Food Chem Toxicol. 2011;49:2594-9 pubmed publisher
    In the present study, the two endemic Soqotraen plants Boswellia elongata and Jatropha unicostata were investigated for their anti-inflammatory, antinociceptive and antioxidant potential...
  6. Moussaieff A, Mechoulam R. Boswellia resin: from religious ceremonies to medical uses; a review of in-vitro, in-vivo and clinical trials. J Pharm Pharmacol. 2009;61:1281-93 pubmed publisher
    Despite its historical-religious, cultural and medical importance, Boswellia has not been thoroughly studied, and gaps still exist between our knowledge of the traditional uses of the resin and the scientific data available...
  7. Liu J, Duan R. LY294002 enhances boswellic acid-induced apoptosis in colon cancer cells. Anticancer Res. 2009;29:2987-91 pubmed
    ..The phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) pathway is crucial for cell proliferation and survival. Whether the apoptotic effects of boswellic acid could be affected by inhibition of PI3K/Akt pathway was examined...
  8. Blain E, Ali A, Duance V. Boswellia frereana (frankincense) suppresses cytokine-induced matrix metalloproteinase expression and production of pro-inflammatory molecules in articular cartilage. Phytother Res. 2010;24:905-12 pubmed publisher
    The aim of this study was to assess the anti-inflammatory efficacy of Boswellia frereana extracts in an in vitro model of cartilage degeneration and determine its potential as a therapy for treating osteoarthritis...
  9. Burlando B, Parodi A, Volante A, Bassi A. Comparison of the irritation potentials of Boswellia serrata gum resin and of acetyl-11-keto-beta-boswellic acid by in vitro cytotoxicity tests on human skin-derived cell lines. Toxicol Lett. 2008;177:144-9 pubmed publisher
    Indian frankincense is a gum resin from Boswellia serrata of Burseraceae used in Ayurveda and Western medicine for the antinflammatory effects of boswellic acids, particularly 3-O-acetyl-11-keto-beta-boswellic acid (AKBA)...
  10. Estrada A, Syrovets T, Pitterle K, Lunov O, Büchele B, Schimana Pfeifer J, et al. Tirucallic acids are novel pleckstrin homology domain-dependent Akt inhibitors inducing apoptosis in prostate cancer cells. Mol Pharmacol. 2010;77:378-87 pubmed publisher
    ..acid, 3-alpha-acetoxy-tirucallic acid, and 3-beta-acetoxy-tirucallic acid from the oleogum resin of Boswellia carterii to chemical homogeneity...
  11. Roy S, Khanna S, Krishnaraju A, Subbaraju G, Yasmin T, Bagchi D, et al. Regulation of vascular responses to inflammation: inducible matrix metalloproteinase-3 expression in human microvascular endothelial cells is sensitive to antiinflammatory Boswellia. Antioxid Redox Signal. 2006;8:653-60 pubmed
    ..Recently we have examined the genetic basis of the antiinflammatory effects of Boswellia extract (BE) in a system of TNFalpha-induced gene expression in human microvascular endothelial cells (HMECs)...
  12. Sengupta K, Krishnaraju A, Vishal A, Mishra A, Trimurtulu G, Sarma K, et al. Comparative efficacy and tolerability of 5-Loxin and AflapinAgainst osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study. Int J Med Sci. 2010;7:366-77 pubmed
    Aflapin(®) is a novel synergistic composition derived from Boswellia serrata gum resin (Indian Patent Application No. 2229/CHE/2008)...
  13. Chevrier M, Ryan A, Lee D, Zhongze M, Wu Yan Z, Via C. Boswellia carterii extract inhibits TH1 cytokines and promotes TH2 cytokines in vitro. Clin Diagn Lab Immunol. 2005;12:575-80 pubmed
    Traditional herbal formulas used to treat inflammatory arthritis in China and India include Boswellia carterii or Boswellia serrata...
  14. Paul M, Brüning G, Bergmann J, Jauch J. A thin-layer chromatography method for the identification of three different olibanum resins (Boswellia serrata, Boswellia papyrifera and Boswellia carterii, respectively, Boswellia sacra). Phytochem Anal. 2012;23:184-9 pubmed publisher
    Resins of the genus Boswellia are currently an interesting topic for pharmaceutical research since several pharmacological activities (e.g...
  15. Atta Ur Rahman -, Naz H, Fadimatou -, Makhmoor T, Yasin A, Fatima N, et al. Bioactive constituents from Boswellia papyrifera. J Nat Prod. 2005;68:189-93 pubmed
    Phytochemical investigation of the stem bark extract of Boswellia papyrifera afforded two new stilbene glycosides, trans-4',5-dihydroxy-3-methoxystilbene-5-O-{alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-..
  16. Pungle P, Banavalikar M, Suthar A, Biyani M, Mengi S. Immunomodulatory activity of boswellic acids of Boswellia serrata Roxb. Indian J Exp Biol. 2003;41:1460-2 pubmed
    ..The results suggest promising antianaphylactic and mast cell stabilizing activity of the extract...
  17. Hostanska K, Daum G, Saller R. Cytostatic and apoptosis-inducing activity of boswellic acids toward malignant cell lines in vitro. Anticancer Res. 2002;22:2853-62 pubmed
    ..Because of the relevance for the clinical application, we tested the ethanolic extract of Boswellia serrata gum resin containing a defined amount of boswellic acids for its cytotoxic, cytostatic and apoptotic ..
  18. Liu J, Nilsson A, Oredsson S, Badmaev V, Zhao W, Duan R. Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. Carcinogenesis. 2002;23:2087-93 pubmed
    Boswellic acids are the effective components of gum resin of Boswellia serrata, which has anti-inflammatory properties...
  19. Raja A, Ali F, Khan I, Shawl A, Arora D, Shah B, et al. Antistaphylococcal and biofilm inhibitory activities of acetyl-11-keto-?-boswellic acid from Boswellia serrata. BMC Microbiol. 2011;11:54 pubmed publisher
    Boswellic acids are pentacyclic triterpenes, which are produced in plants belonging to the genus Boswellia. Boswellic acids appear in the resin exudates of the plant and it makes up 25-35% of the resin...
  20. Al Saidi S, Rameshkumar K, Hisham A, Sivakumar N, Al Kindy S. Composition and antibacterial activity of the essential oils of four commercial grades of Omani luban, the oleo-gum resin of Boswellia sacra FLUECK. Chem Biodivers. 2012;9:615-24 pubmed publisher
    ..of four botanically certified and commercially available samples of Omani lubans (oleo-gum resins of Boswellia sacra Flueck...
  21. Ahmed M, Al Daghri N, Alokail M, Hussain T. Potential changes in rat spermatogenesis and sperm parameters after inhalation of Boswellia papyrifera and Boswellia carterii incense. Int J Environ Res Public Health. 2013;10:830-44 pubmed publisher
    In this study the effect of Boswellia papyrifera (B. papyrifera) and Boswellia carterii (B. carterii) smoke exposure on spermatogenesis and sperm parameters in male albino rats was investigated...
  22. Moussaieff A, Shein N, Tsenter J, Grigoriadis S, Simeonidou C, Alexandrovich A, et al. Incensole acetate: a novel neuroprotective agent isolated from Boswellia carterii. J Cereb Blood Flow Metab. 2008;28:1341-52 pubmed publisher
    b>Boswellia resin has been used as a major anti-inflammatory agent and for the healing of wounds for centuries...
  23. Sengupta K, Alluri K, Satish A, Mishra S, Golakoti T, Sarma K, et al. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the knee. Arthritis Res Ther. 2008;10:R85 pubmed publisher
    5-Loxin is a novel Boswellia serrata extract enriched with 30% 3-O-acetyl-11-keto-beta-boswellic acid (AKBA), which exhibits potential anti-inflammatory properties by inhibiting the 5-lipoxygenase enzyme...
  24. Shah B, Kumar A, Gupta P, Sharma M, Sethi V, Saxena A, et al. Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids. Bioorg Med Chem Lett. 2007;17:6411-6 pubmed
    ..The same molecules also exhibited apoptotic activity by inducing DNA fragmentation...
  25. Bhushan S, Kumar A, Malik F, Andotra S, Sethi V, Kaur I, et al. A triterpenediol from Boswellia serrata induces apoptosis through both the intrinsic and extrinsic apoptotic pathways in human leukemia HL-60 cells. Apoptosis. 2007;12:1911-26 pubmed
    ..TPD) comprising of isomeric mixture of 3alpha, 24-dihydroxyurs-12-ene and 3alpha, 24-dihydroxyolean-12-ene from Boswellia serrata induces apoptosis in cancer cells...
  26. Mikhaeil B, Maatooq G, Badria F, Amer M. Chemistry and immunomodulatory activity of frankincense oil. Z Naturforsch C. 2003;58:230-8 pubmed
    ..Biologically, the oil exhibited a strong immunostimulant activity (90% lymphocyte transformation) when assessed by a lymphocyte proliferation assay...
  27. Moussaieff A, Shohami E, Kashman Y, Fride E, Schmitz M, Renner F, et al. Incensole acetate, a novel anti-inflammatory compound isolated from Boswellia resin, inhibits nuclear factor-kappa B activation. Mol Pharmacol. 2007;72:1657-64 pubmed
    b>Boswellia resin is a major anti-inflammatory agent in herbal medical tradition, as well as a common food supplement. Its anti-inflammatory activity has been attributed to boswellic acid and its derivatives...
  28. Fan A, Lao L, Zhang R, Zhou A, Wang L, Moudgil K, et al. Effects of an acetone extract of Boswellia carterii Birdw. (Burseraceae) gum resin on adjuvant-induced arthritis in lewis rats. J Ethnopharmacol. 2005;101:104-9 pubmed
    Ruxiang (Gummi olibanum), the dried gum resin of Boswellia carterii (BC), has been used in traditional Chinese medicine to alleviate pain and inflammation for thousands of years...
  29. Mahmoudi A, Hosseini Sharifabad A, Monsef Esfahani H, Yazdinejad A, Khanavi M, Roghani A, et al. Evaluation of systemic administration of Boswellia papyrifera extracts on spatial memory retention in male rats. J Nat Med. 2011;65:519-25 pubmed publisher
    Time-dependent effects of ethanolic extract of Boswellia papyrifera, administered systemically, on spatial memory retention in the Morris water maze were investigated in male rats...
  30. Krishnaraju A, Sundararaju D, Vamsikrishna U, Suryachandra R, Machiraju G, Sengupta K, et al. Safety and toxicological evaluation of Aflapin: a novel Boswellia-derived anti-inflammatory product. Toxicol Mech Methods. 2010;20:556-63 pubmed publisher
    b>Boswellia serrata gum resin has been used for treatment of various ailments in different cultures for thousands of years. Aflapin(®) is a novel synergistic composition derived from B. serrata gum resin (Indian Patent Application No...
  31. Fan A, Lao L, Zhang R, Wang L, Lee D, Ma Z, et al. Effects of an acetone extract of Boswellia carterii Birdw. (Burseraceae) gum resin on rats with persistent inflammation. J Altern Complement Med. 2005;11:323-31 pubmed
    Ruxiang, or Gummi olibanum, an herbal medicine derived from the gum resin of Boswellia carterii Birdw. (BC) of the family Burseraceae, has been used traditionally in China to alleviate pain and reduce inflammation...
  32. Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine. 2003;10:3-7 pubmed
    ..b>Boswellia serrata tree is commonly found in India. The therapeutic value of its gum (guggulu) has been known...
  33. Kruger P, Kanzer J, Hummel J, Fricker G, Schubert Zsilavecz M, Abdel Tawab M. Permeation of Boswellia extract in the Caco-2 model and possible interactions of its constituents KBA and AKBA with OATP1B3 and MRP2. Eur J Pharm Sci. 2009;36:275-84 pubmed publisher
    Traditionally Boswellia serrata extract is used in the Indian Ayurvedic medicine for the treatment of inflammatory diseases. In 2002 the EMEA designated Boswellia an orphan drug status for the treatment of peritumoral oedema...
  34. Altmann A, Fischer L, Schubert Zsilavecz M, Steinhilber D, Werz O. Boswellic acids activate p42(MAPK) and p38 MAPK and stimulate Ca(2+) mobilization. Biochem Biophys Res Commun. 2002;290:185-90 pubmed
    Here we show that extracts of Boswellia serrata gum resins and its constituents, the boswellic acids (BAs), activate the mitogen-activated protein kinases (MAPK) p42(MAPK) and p38 in isolated human polymorphonuclear leukocytes (PMNL)...
  35. Latella G, Sferra R, Vetuschi A, Zanninelli G, D Angelo A, Catitti V, et al. Prevention of colonic fibrosis by Boswellia and Scutellaria extracts in rats with colitis induced by 2,4,5-trinitrobenzene sulphonic acid. Eur J Clin Invest. 2008;38:410-20 pubmed publisher
    ..The aim of this study was to evaluate the efficacy of a combined therapy of anti-inflammatory Boswellia and antifibrotic Scutellaria extracts on the development of colonic fibrosis in rats.
  36. Paul M, Jauch J. Efficient preparation of incensole and incensole acetate, and quantification of these bioactive diterpenes in Boswellia papyrifera by a RP-DAD-HPLC method. Nat Prod Commun. 2012;7:283-8 pubmed
    ..Starting from crude extracts of the incense species Boswellia papyrifera Hochst...
  37. Suhail M, Wu W, Cao A, Mondalek F, Fung K, Shih P, et al. Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells. BMC Complement Altern Med. 2011;11:129 pubmed publisher
    Gum resins obtained from trees of the Burseraceae family (Boswellia sp.) are important ingredients in incense and perfumes. Extracts prepared from Boswellia sp...
  38. Moore P. Conservation biology: unkind cuts for incense. Nature. 2006;444:829 pubmed
  39. Roy S, Khanna S, Shah H, Rink C, Phillips C, Preuss H, et al. Human genome screen to identify the genetic basis of the anti-inflammatory effects of Boswellia in microvascular endothelial cells. DNA Cell Biol. 2005;24:244-55 pubmed
    ..Medicinal plants belonging to the Burseraceae family, including Boswellia, are especially known for their anti-inflammatory properties...
  40. Banno N, Akihisa T, Yasukawa K, Tokuda H, Tabata K, Nakamura Y, et al. Anti-inflammatory activities of the triterpene acids from the resin of Boswellia carteri. J Ethnopharmacol. 2006;107:249-53 pubmed
    Boswellic acids are the main well-known active components of the resin of Boswellia carteri (Burseraceae) and these are still dealing with the ethnomedicinal use for the treatment of rheumatoid arthritis and other inflammatory diseases...
  41. Woolley C, Suhail M, Smith B, Boren K, Taylor L, Schreuder M, et al. Chemical differentiation of Boswellia sacra and Boswellia carterii essential oils by gas chromatography and chiral gas chromatography-mass spectrometry. J Chromatogr A. 2012;1261:158-63 pubmed publisher
    Major botanical and scientific references currently identify two species of frankincense, Boswellia carterii and Boswellia sacra, as being synonymous. We evaluated the Somalian (B. carterii) and Omani/Yemeni (B...
  42. Sferra R, Vetuschi A, Catitti V, Ammanniti S, Pompili S, Melideo D, et al. Boswellia serrata and Salvia miltiorrhiza extracts reduce DMN-induced hepatic fibrosis in mice by TGF-beta1 downregulation. Eur Rev Med Pharmacol Sci. 2012;16:1484-98 pubmed
    ..Transforming growth factor-beta1 (TGF-beta)/Smad3 signalling plays a major role in tissue fibrogenesis acting as a potent stimulus of ECM accumulation...
  43. Kirste S, Treier M, Wehrle S, Becker G, Abdel Tawab M, Gerbeth K, et al. Boswellia serrata acts on cerebral edema in patients irradiated for brain tumors: a prospective, randomized, placebo-controlled, double-blind pilot trial. Cancer. 2011;117:3788-95 pubmed publisher
    ..To investigate the activity of Boswellia serrata (BS) in radiotherapy-related edema, we conducted a prospective, randomized, placebo-controlled, double-..
  44. Ammon H. Modulation of the immune system by Boswellia serrata extracts and boswellic acids. Phytomedicine. 2010;17:862-7 pubmed publisher
    Extracts from the gum resin of Boswellia serrata and some of is constituents including boswellic acids affect the immune system in different ways...
  45. Sterk V, Büchele B, Simmet T. Effect of food intake on the bioavailability of boswellic acids from a herbal preparation in healthy volunteers. Planta Med. 2004;70:1155-60 pubmed
    ..on the bioavailability of distinct boswellic acids (BAs) from the test preparation BSE-018, a dry extract from Boswellia serrata gum resin...
  46. Ali S, Zhang C, Mohamed A, El Baz F, Hegazy A, Kord M, et al. Major constituents of Boswellia carteri resin exhibit cyclooxygenase enzyme inhibition and antiproliferative activity. Nat Prod Commun. 2013;8:1365-6 pubmed
    Aromatic gum from Boswellia carteri (olibanum oleogum) has long been used in Egyptian traditional medicine...
  47. Singh S, Khajuria A, Taneja S, Khajuria R, Singh J, Johri R, et al. The gastric ulcer protective effect of boswellic acids, a leukotriene inhibitor from Boswellia serrata, in rats. Phytomedicine. 2008;15:408-15 pubmed publisher
    ..Nevertheless it is possible that BA might be acting by increasing the gastric mucosal resistance and local synthesis of cytoprotective prostaglandins and inhibiting the leukotriene synthesis...
  48. Ni X, Suhail M, Yang Q, Cao A, Fung K, Postier R, et al. Frankincense essential oil prepared from hydrodistillation of Boswellia sacra gum resins induces human pancreatic cancer cell death in cultures and in a xenograft murine model. BMC Complement Altern Med. 2012;12:253 pubmed publisher
    ..Gum resins from Boswellia species, also known as frankincense, have been used as a major ingredient in Ayurvedic and Chinese medicine to ..
  49. Shehata A, Quintanilla Fend L, Bettio S, Singh C, Ammon H. Prevention of multiple low-dose streptozotocin (MLD-STZ) diabetes in mice by an extract from gum resin of Boswellia serrata (BE). Phytomedicine. 2011;18:1037-44 pubmed publisher
    ..Extracts from gum resin of Boswellia serrata (BE) have been shown to posses anti-inflammatory properties especially by targeting factors/mediators ..
  50. Bhushan S, Malik F, Kumar A, Isher H, Kaur I, Taneja S, et al. Activation of p53/p21/PUMA alliance and disruption of PI-3/Akt in multimodal targeting of apoptotic signaling cascades in cervical cancer cells by a pentacyclic triterpenediol from Boswellia serrata. Mol Carcinog. 2009;48:1093-108 pubmed publisher
    ..the apoptotic cell death in human cervical cancer HeLa and SiHa cells by a pentacyclic triterpenediol (TPD) from Boswellia serrata by a mechanism different from reported in HL-60 cells...
  51. Frank M, Yang Q, Osban J, Azzarello J, Saban M, Saban R, et al. Frankincense oil derived from Boswellia carteri induces tumor cell specific cytotoxicity. BMC Complement Altern Med. 2009;9:6 pubmed publisher
    ..Frankincense oil is prepared from aromatic hardened gum resins obtained by tapping Boswellia trees...
  52. Schillaci D, Arizza V, Dayton T, Camarda L, Di Stefano V. In vitro anti-biofilm activity of Boswellia spp. oleogum resin essential oils. Lett Appl Microbiol. 2008;47:433-8 pubmed publisher
    To evaluate the anti-biofilm activity of the commercially available essential oils from two Boswellia species.
  53. Abdel Tawab M, Werz O, Schubert Zsilavecz M. Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data. Clin Pharmacokinet. 2011;50:349-69 pubmed publisher
    ..In the last two decades, preparations of the gum resin of Boswellia serrata (a traditional ayurvedic medicine) and of other Boswellia species have experienced increasing popularity ..
  54. Mahmoud M, Diaai A, Ahmed F. Evaluation of the efficacy of ginger, Arabic gum, and Boswellia in acute and chronic renal failure. Ren Fail. 2012;34:73-82 pubmed publisher
    This study was conducted to evaluate the effects of Zingiber officinale Roscoe (Ginger), Arabic gum (AG), and Boswellia on both acute and chronic renal failure (CRF) and the mechanisms underlying their effects...
  55. Gayathri B, Manjula N, Vinaykumar K, Lakshmi B, Balakrishnan A. Pure compound from Boswellia serrata extract exhibits anti-inflammatory property in human PBMCs and mouse macrophages through inhibition of TNFalpha, IL-1beta, NO and MAP kinases. Int Immunopharmacol. 2007;7:473-82 pubmed
    The aim of the present study is to probe the anti-inflammatory potential of the plant Boswellia serrata by studying the effect of the crude extract and the pure compound isolated from it on key inflammatory mediators like TNFalpha, IL-..
  56. Sengupta K, Kolla J, Krishnaraju A, Yalamanchili N, Rao C, Golakoti T, et al. Cellular and molecular mechanisms of anti-inflammatory effect of Aflapin: a novel Boswellia serrata extract. Mol Cell Biochem. 2011;354:189-97 pubmed publisher
    There is significant number of evidences suggesting the anti-inflammatory properties of gum resin extracts of Boswellia serrata containing 3-O-acetyl-11-keto-?-boswellic acid (AKBA) and their promising potential as therapeutic ..
  57. Madisch A, Miehlke S, Eichele O, Mrwa J, Bethke B, Kuhlisch E, et al. Boswellia serrata extract for the treatment of collagenous colitis. A double-blind, randomized, placebo-controlled, multicenter trial. Int J Colorectal Dis. 2007;22:1445-51 pubmed
    The objective of this study was to investigate the effect of Boswellia serrata extract (BSE) on symptoms, quality of life, and histology in patients with collagenous colitis.
  58. Bhushan S, Kakkar V, Pal H, Guru S, Kumar A, Mondhe D, et al. Enhanced anticancer potential of encapsulated solid lipid nanoparticles of TPD: a novel triterpenediol from Boswellia serrata. Mol Pharm. 2013;10:225-35 pubmed publisher
    A pentacyclic triterpenediol (TPD) from Boswellia serrata has significant cytotoxic and apoptotic potential in a large number of human cancer cell lines...
  59. Schmidt T, Kaiser M, Brun R. Complete structural assignment of serratol, a cembrane-type diterpene from Boswellia serrata, and evaluation of its antiprotozoal activity. Planta Med. 2011;77:849-50 pubmed publisher
    From the dichloromethane extract obtained from the gum resin of Boswellia serrata Roxb. (Burseraceae), a well-known medicinal plant resin ("Indian Olibanum"), the cembrane-type diterpene serratol was isolated in high yield...