lepidium

Summary

Summary: A plant genus of the family BRASSICACEAE growing in Peru mountains. It is the source of maca root.

Top Publications

  1. Bustos Obregon E, Yucra S, Gonzales G. Lepidium meyenii (Maca) reduces spermatogenic damage induced by a single dose of malathion in mice. Asian J Androl. 2005;7:71-6 pubmed
    To observe the effect of the aqueous extract of hypocotyls of the plant Lepidium meyenii (Maca) on spermatogenic damage induced by the organophosphate insecticide malathion in mice.
  2. Chung F, Rubio J, Gonzales C, Gasco M, Gonzales G. Dose-response effects of Lepidium meyenii (Maca) aqueous extract on testicular function and weight of different organs in adult rats. J Ethnopharmacol. 2005;98:143-7 pubmed
    b>Lepidium meyenii (Brassicaceae) known as Maca grows exclusively between 4000 and 4500 m over the sea level in the Peruvian central Andes...
  3. Shin B, Lee M, Yang E, Lim H, Ernst E. Maca (L. meyenii) for improving sexual function: a systematic review. BMC Complement Altern Med. 2010;10:44 pubmed publisher
    Maca (Lepidium meyenii) is an Andean plant of the brassica (mustard) family. Preparations from maca root have been reported to improve sexual function...
  4. Gonzales C, Cárdenas Valencia I, Leiva Revilla J, Anza Ramirez C, Rubio J, Gonzales G. Effects of different varieties of Maca (Lepidium meyenii) on bone structure in ovariectomized rats. Forsch Komplementmed. 2010;17:137-43 pubmed publisher
    This study was designed to determine the effect of different varieties of maca (Lepidium meyenii) on bone structure in ovariectomized (OVX) rats.
  5. Choi H, Ahn S, Lee B, Chang I, Hwang J. Inhibition of skin pigmentation by an extract of Lepidium apetalum and its possible implication in IL-6 mediated signaling. Pigment Cell Res. 2005;18:439-46 pubmed
    ..We present here that an extract of Lepidium apetalum (ELA) decreased UV-induced skin pigmentation in brown guinea pigs and melanogenesis of HM3KO human ..
  6. Oshima M, Gu Y, Tsukada S. Effects of Lepidium meyenii Walp and Jatropha macrantha on blood levels of estradiol-17 beta, progesterone, testosterone and the rate of embryo implantation in mice. J Vet Med Sci. 2003;65:1145-6 pubmed
    The effects of two Peruvian folk medicines, Lepidium meyenii Walp and Jatropha macrantha, on mouse sex steroid hormones and embryo implantation were investigated. Progesterone levels increased significantly in mice that received L...
  7. Zhang Y, Yu L, Ao M, Jin W. Effect of ethanol extract of Lepidium meyenii Walp. on osteoporosis in ovariectomized rat. J Ethnopharmacol. 2006;105:274-9 pubmed
    Maca (Lepidium meyenii Walp.) is a cruciferous plant from the Andes of Peru...
  8. Gasco M, Aguilar J, Gonzales G. Effect of chronic treatment with three varieties of Lepidium meyenii (Maca) on reproductive parameters and DNA quantification in adult male rats. Andrologia. 2007;39:151-8 pubmed
    The aim of this study was to evaluate the chronic effect of different varieties of Lepidium meyenii (Red Maca, Yellow Maca and Black Maca)...
  9. Yucra S, Gasco M, Rubio J, Nieto J, Gonzales G. Effect of different fractions from hydroalcoholic extract of Black Maca (Lepidium meyenii) on testicular function in adult male rats. Fertil Steril. 2008;89:1461-7 pubmed
    To evaluate the effect of different fractions of Black Maca (Lepidium meyenii), obtained from the hydroalcoholic extract, on spermatogenesis.

More Information

Publications89

  1. López Fando A, Gómez Serranillos M, Iglesias I, Lock O, Upamayta U, Carretero M. Lepidium peruvianum chacon restores homeostasis impaired by restraint stress. Phytother Res. 2004;18:471-4 pubmed
    b>Lepidium peruvianum root has been traditionally utilized by native Peruvians, since before the time of the Incas, for both nutritional and putative medicinal purposes as an adaptogen and also to enhance fertility in humans and animals...
  2. Valentova K, Ulrichova J. Smallanthus sonchifolius and Lepidium meyenii - prospective Andean crops for the prevention of chronic diseases. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2003;147:119-30 pubmed
    Smallanthus sonchifolius (yacon) and Lepidium meyenii (maca) were the traditional crops of the original population of Peru where they are also still used in folk medicine...
  3. Ruiz Luna A, Salazar S, Aspajo N, Rubio J, Gasco M, Gonzales G. Lepidium meyenii (Maca) increases litter size in normal adult female mice. Reprod Biol Endocrinol. 2005;3:16 pubmed
    b>Lepidium meyenii, known as Maca, grows exclusively in the Peruvian Andes over 4000 m altitude. It has been used traditionally to increase fertility...
  4. Gasco M, Villegas L, Yucra S, Rubio J, Gonzales G. Dose-response effect of Red Maca (Lepidium meyenii) on benign prostatic hyperplasia induced by testosterone enanthate. Phytomedicine. 2007;14:460-4 pubmed
    The main goal of this study was to determine the effect of a freeze-dried aqueous extract of the red variety of Lepidium meyenii (Red Maca) on testosterone-induced benign prostatic hyperplasia (BPH) in adult rats of the Holtzman strain...
  5. Mummenhoff K, Polster A, Mühlhausen A, Theissen G. Lepidium as a model system for studying the evolution of fruit development in Brassicaceae. J Exp Bot. 2009;60:1503-13 pubmed publisher
    ..molecular markers indicate that the development of dehiscent fruits is the ancestral condition within the genus Lepidium s.l., but that indehiscent fruits evolved independently several times from dehiscent fruits...
  6. Zenico T, Cicero A, Valmorri L, Mercuriali M, Bercovich E. Subjective effects of Lepidium meyenii (Maca) extract on well-being and sexual performances in patients with mild erectile dysfunction: a randomised, double-blind clinical trial. Andrologia. 2009;41:95-9 pubmed publisher
    b>Lepidium meyenii (Maca) is a cultivated root belonging to the brassica family used in the Andean region for its supposed aphrodisiac properties...
  7. Piacente S, Carbone V, Plaza A, Zampelli A, Pizza C. Investigation of the tuber constituents of maca (Lepidium meyenii Walp.). J Agric Food Chem. 2002;50:5621-5 pubmed
    b>Lepidium meyenii, known in South America as maca, has received attention worldwide as a powerful energizer that improves physical and mental conditions and increases fertility...
  8. Gupta S, Pandey P, Grover A, Patade V, Singh S, Ahmed Z. Cloning and characterization of GPAT gene from Lepidium latifolium L.: a step towards translational research in agri-genomics for food and fuel. Mol Biol Rep. 2013;40:4235-40 pubmed publisher
    ..Here, we report cloning and characterization of GPAT gene from Lepidium latifolium (LlaGPAT)...
  9. Aslam M, Grover A, Sinha V, Fakher B, Pande V, Yadav P, et al. Isolation and characterization of cold responsive NAC gene from Lepidium latifolium. Mol Biol Rep. 2012;39:9629-38 pubmed publisher
    ..Here, we have cloned full length NAC gene (1,388 bp) from Lepidium latifolium (LlaNAC)...
  10. Stone M, Ibarra A, Roller M, Zangara A, Stevenson E. A pilot investigation into the effect of maca supplementation on physical activity and sexual desire in sportsmen. J Ethnopharmacol. 2009;126:574-6 pubmed publisher
    Maca (Lepidium meyenii Walp) is consumed both as a sports supplement by strength and endurance athletes, and as a natural stimulant to enhance sexual drive...
  11. Bogani P, Simonini F, Iriti M, Rossoni M, Faoro F, Poletti A, et al. Lepidium meyenii (Maca) does not exert direct androgenic activities. J Ethnopharmacol. 2006;104:415-7 pubmed
    ..Further experiments are needed to assess which compound, of the several Maca's components, is responsible of the observed in vivo effects...
  12. Gonzales C, Rubio J, Gasco M, Nieto J, Yucra S, Gonzales G. Effect of short-term and long-term treatments with three ecotypes of Lepidium meyenii (MACA) on spermatogenesis in rats. J Ethnopharmacol. 2006;103:448-54 pubmed
    b>Lepidium meyenii (Brassicaceae), known as Maca, is a Peruvian hypocotyl that grows exclusively between 4000 and 4500 m above sea level in the central Andes...
  13. Clément C, Diaz Grados D, Avula B, Khan I, Mayer A, Ponce Aguirre D, et al. Influence of colour type and previous cultivation on secondary metabolites in hypocotyls and leaves of maca (Lepidium meyenii Walpers). J Sci Food Agric. 2010;90:861-9 pubmed publisher
    ..The effects of colour type and of previous cultivation of the field were examined...
  14. Gonzales G, Ruiz A, Gonzales C, Villegas L, Cordova A. Effect of Lepidium meyenii (maca) roots on spermatogenesis of male rats. Asian J Androl. 2001;3:231-3 pubmed
    To determine the effect of oral administration of an aqueous extract from the roots of Lepidium meyenii (maca) on spermatogenesis in adult male rats.
  15. Muhammad I, Zhao J, Dunbar D, Khan I. Constituents of Lepidium meyenii 'maca'. Phytochemistry. 2002;59:105-10 pubmed
    The tubers of Lepidium meyenii contain the benzylated derivative of 1,2-dihydro-N-hydroxypyridine, named macaridine, together with the benzylated alkamides (macamides), N-benzyl-5-oxo-6E,8E-octadecadienamide and N-benzylhexadecanamide, as ..
  16. Lentz A, Gravitt K, Carson C, Marson L. Acute and chronic dosing of Lepidium meyenii (Maca) on male rat sexual behavior. J Sex Med. 2007;4:332-9; discussion 339-40 pubmed
    ..For generations people of the rural community in Peru have used Lepidium meyenii Walpers (Maca), because of their belief that it improves fertility and sexual desire.
  17. Dording C, Fisher L, Papakostas G, Farabaugh A, Sonawalla S, Fava M, et al. A double-blind, randomized, pilot dose-finding study of maca root (L. meyenii) for the management of SSRI-induced sexual dysfunction. CNS Neurosci Ther. 2008;14:182-91 pubmed publisher
    ..Maca was well tolerated. Maca root may alleviate SSRI-induced sexual dysfunction, and there may be a dose-related effect. Maca may also have a beneficial effect on libido...
  18. Gonzales Castañeda C, Gonzales G. Hypocotyls of Lepidium meyenii (maca), a plant of the Peruvian highlands, prevent ultraviolet A-, B-, and C-induced skin damage in rats. Photodermatol Photoimmunol Photomed. 2008;24:24-31 pubmed publisher
    b>Lepidium meyenii (maca) is a plant that grows exclusively in the Peruvian Central Andes, where ultraviolet radiation (UVR) is predominant.
  19. Mühlhausen A, Lenser T, Mummenhoff K, Theißen G. Evidence that an evolutionary transition from dehiscent to indehiscent fruits in Lepidium (Brassicaceae) was caused by a change in the control of valve margin identity genes. Plant J. 2013;73:824-35 pubmed publisher
    ..Here we use closely related wild species of the genus Lepidium as a model system to analyse the underlying developmental genetic mechanisms in a candidate gene approach...
  20. Miller M, Ahmed S, Bobrowski P, Haqqi T. The chrondoprotective actions of a natural product are associated with the activation of IGF-1 production by human chondrocytes despite the presence of IL-1beta. BMC Complement Altern Med. 2006;6:13 pubmed
    ..The other extract, derived from the vegetable Lepidium meyenii (RNI 249), possessed an uncertain mechanism of action but with defined ethnomedical applications for ..
  21. Valentova K, Buckiova D, Kren V, Peknicova J, Ulrichova J, Simanek V. The in vitro biological activity of Lepidium meyenii extracts. Cell Biol Toxicol. 2006;22:91-9 pubmed
    The biological activity of methanolic and aqueous extracts from dehydrated hypocotyls of Lepidium meyenii (Brassicaceae, vernacular name "maca"), was studied on rat hepatocytes and human breast cancer MCF-7 cells...
  22. Lee M, Shin B, Yang E, Lim H, Ernst E. Maca (Lepidium meyenii) for treatment of menopausal symptoms: A systematic review. Maturitas. 2011;70:227-33 pubmed publisher
    Maca (Lepidium meyenii), an Andean plant of the brassica (mustard) family has been used for centuries in the Andes as an adaptogenic plant to manage anemia, infertility and female hormone balance...
  23. Kassie F, Rabot S, Uhl M, Huber W, Qin H, Helma C, et al. Chemoprotective effects of garden cress (Lepidium sativum) and its constituents towards 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ)-induced genotoxic effects and colonic preneoplastic lesions. Carcinogenesis. 2002;23:1155-61 pubmed
    The chemoprotective effect of garden cress (GC, Lepidium sativum) and its constituents, glucotropaeolin (GT) and benzylisothiocyanate (BITC), a breakdown product of GT, towards 2-amino-3-methyl-imidazo [4,5-f] quinoline (IQ)-induced ..
  24. Cui B, Zheng B, He K, Zheng Q. Imidazole alkaloids from Lepidium meyenii. J Nat Prod. 2003;66:1101-3 pubmed
    Two new imidazole alkaloids (lepidiline A and lepidiline B) have been isolated from a root extract of Lepidium meyenii with the common name Maca and identified as 1,3-dibenzyl-4,5-dimethylimidazolium chloride (1) and 1,3-dibenzyl-2,4,5-..
  25. Valentova K, Stejskal D, Bartek J, Dvorácková S, Kren V, Ulrichova J, et al. Maca (Lepidium meyenii) and yacon (Smallanthus sonchifolius) in combination with silymarin as food supplements: in vivo safety assessment. Food Chem Toxicol. 2008;46:1006-13 pubmed
    ..The effect of maca on AST level and blood pressure must be considered when using high doses of maca powder. This effect could be reversed by supplementation with silymarin...
  26. Rubio J, Dang H, Gong M, Liu X, Chen S, Gonzales G. Aqueous and hydroalcoholic extracts of Black Maca (Lepidium meyenii) improve scopolamine-induced memory impairment in mice. Food Chem Toxicol. 2007;45:1882-90 pubmed
    b>Lepidium meyenii Walp. (Brassicaceae), known as Maca, is a Peruvian hypocotyl growing exclusively between 4,000 and 4,500 m altitude in the central Peruvian Andes, particularly in Junin plateau...
  27. Pino Figueroa A, Nguyen D, Maher T. Neuroprotective effects of Lepidium meyenii (Maca). Ann N Y Acad Sci. 2010;1199:77-85 pubmed publisher
    The neuroprotective activity of the plant Lepidium meyenii (Maca) was studied in two experimental models: in vitro and in vivo...
  28. Rubio J, Riqueros M, Gasco M, Yucra S, Miranda S, Gonzales G. Lepidium meyenii (Maca) reversed the lead acetate induced -- damage on reproductive function in male rats. Food Chem Toxicol. 2006;44:1114-22 pubmed
    ..Maca prevented LA-induced spermatogenic disruption in rats and it may become in a potential treatment of male infertility associated with lead exposure...
  29. McCollom M, Villinski J, McPhail K, Craker L, Gafner S. Analysis of macamides in samples of Maca (Lepidium meyenii) by HPLC-UV-MS/MS. Phytochem Anal. 2005;16:463-9 pubmed
    The macamides are a distinct class of secondary metabolites that have so far been found only in Lepidium meyenii Walp. (Maca)...
  30. Valerio L, Gonzales G. Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii) : a critical synopsis. Toxicol Rev. 2005;24:11-35 pubmed
    ..historical and current global use: Uncaria tomentosa (common name: cat's claw, and Spanish: uña de gato), and Lepidium meyenii (common name: maca)...
  31. Gaskin J, Zhang D, Bon M. Invasion of Lepidium draba (Brassicaceae) in the western United States: distributions and origins of chloroplast DNA haplotypes. Mol Ecol. 2005;14:2331-41 pubmed
    ..In this study, we investigated a highly variable chloroplast DNA (cpDNA) marker for populations of the weed Lepidium draba (Brassicaceae) in its native Eurasian and invasive US ranges...
  32. Gonzales G, Gasco M, Malheiros Pereira A, Gonzales Castañeda C. Antagonistic effect of Lepidium meyenii (red maca) on prostatic hyperplasia in adult mice. Andrologia. 2008;40:179-85 pubmed publisher
    The plants from the Lepidium gender have demonstrated to have effect on the size of the prostate. Lepidium meyenii (Maca) is a Peruvian plant that grows exclusively over 4000 m above sea level...
  33. Brooks N, Wilcox G, Walker K, Ashton J, Cox M, Stojanovska L. Beneficial effects of Lepidium meyenii (Maca) on psychological symptoms and measures of sexual dysfunction in postmenopausal women are not related to estrogen or androgen content. Menopause. 2008;15:1157-62 pubmed publisher
    To examine the estrogenic and androgenic activity of Lepidium meyenii (Maca) and its effect on the hormonal profile and symptoms in postmenopausal women.
  34. Gonzales G, Miranda S, Nieto J, Fernández G, Yucra S, Rubio J, et al. Red maca (Lepidium meyenii) reduced prostate size in rats. Reprod Biol Endocrinol. 2005;3:5 pubmed
    ..The absolute content of glucosinolates in Maca hypocotyls is relatively higher than that reported in other cruciferous crops. Therefore, Maca may have proapoptotic and anti-proliferative effects in the prostate...
  35. Dierschke T, Mandáková T, Lysak M, Mummenhoff K. A bicontinental origin of polyploid Australian/New Zealand Lepidium species (Brassicaceae)? Evidence from genomic in situ hybridization. Ann Bot. 2009;104:681-8 pubmed publisher
    ..nucleotide positions in internal transcribed spacer (ITS) sequences of polyploid Australian/New Zealand (NZ) Lepidium species have been used to suggest a bicontinental hybrid origin...
  36. Gonzales G, Cordova A, Vega K, Chung A, Villena A, Góñez C. Effect of Lepidium meyenii (Maca), a root with aphrodisiac and fertility-enhancing properties, on serum reproductive hormone levels in adult healthy men. J Endocrinol. 2003;176:163-8 pubmed
    b>Lepidium meyenii (Maca) is a Peruvian hypocotyl that grows exclusively between 4000 and 4500 m in the central Andes. Maca is traditionally employed in the Andean region for its supposed aphrodisiac and/or fertility-enhancing properties...
  37. Gonzales G, Cordova A, Vega K, Chung A, Villena A, Góñez C, et al. Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men. Andrologia. 2002;34:367-72 pubmed
    ..In conclusion, treatment with Maca improved sexual desire...
  38. Vecera R, Orolin J, Skottová N, Kazdova L, Oliyarnik O, Ulrichova J, et al. The influence of maca (Lepidium meyenii) on antioxidant status, lipid and glucose metabolism in rat. Plant Foods Hum Nutr. 2007;62:59-63 pubmed
  39. Cicero A, Piacente S, Plaza A, Sala E, Arletti R, Pizza C. Hexanic Maca extract improves rat sexual performance more effectively than methanolic and chloroformic Maca extracts. Andrologia. 2002;34:177-9 pubmed
    b>Lepidium meyenii (Maca) is traditionally employed in the Andean region for its supposed properties in improving fertility...
  40. Gonzales G, Rubio J, Chung A, Gasco M, Villegas L. Effect of alcoholic extract of Lepidium meyenii (Maca) on testicular function in male rats. Asian J Androl. 2003;5:349-52 pubmed
    To evaluate the effect of the alcoholic extract of Lepidium meyenii (Maca) on the spermatogenesis in male rats.
  41. Gonzales G, Gasco M, Cordova A, Chung A, Rubio J, Villegas L. Effect of Lepidium meyenii (Maca) on spermatogenesis in male rats acutely exposed to high altitude (4340 m). J Endocrinol. 2004;180:87-95 pubmed
    b>Lepidium meyenii (Maca) is a Peruvian hypocotyl that grows exclusively between 4000 and 4500 m in the central Andes. Maca is traditionally employed in the Andean region for its supposed fertility-enhancing properties...
  42. Martinez Caballero S, Carricajo Fernández C, Perez Fernandez R. Effect of an integral suspension of Lepidium latifolium on prostate hyperplasia in rats. Fitoterapia. 2004;75:187-91 pubmed
    This paper studies the effect of an integral suspension of Lepidium latifolium on experimental induced prostate hyperplasia, in rats. Oral treatment with 0...
  43. Gonzales G, Cordova A, Gonzales C, Chung A, Vega K, Villena A. Lepidium meyenii (Maca) improved semen parameters in adult men. Asian J Androl. 2001;3:301-3 pubmed
    The present study was designed to determine the effect of a 4-month oral treatment with tablets of Lepidium meyenii (Maca) on seminal analysis in nine adult normal men aged 24-44 years old.
  44. Fattahian Y, Riahi Madvar A, Mirzaee R, Asadikaram G, Rahbar M. In silico locating the immune-reactive segments of Lepidium draba peroxidase and designing a less immune-reactive enzyme derivative. Comput Biol Chem. 2017;70:21-30 pubmed publisher
    ..In the present study, a horseradish peroxidase homologue from Lepidium draba was subjected to in silico analyzes aiming at identifying and locating immune-reactive regions...
  45. Schmasow M, Robertson I. Selective Foraging by Pogonomyrmex salinus (Hymenoptera: Formicidae) in Semiarid Grassland: Implications for a Rare Plant. Environ Entomol. 2016;45:952-60 pubmed publisher
    ..by two species of grass, Poa secunda and Bromus tectorum, and two species of mustard, Sisymbrium altissimum and Lepidium papilliferum The latter is a rare plant endemic to southwestern Idaho, and its seeds are readily consumed by P...
  46. Kaur T, Bhat R, Khajuria M, Vyas R, Kumari A, Nadda G, et al. Dynamics of glucosinolate-myrosinase system during Plutella xylostella interaction to a novel host Lepidium latifolium L. Plant Sci. 2016;250:1-9 pubmed publisher
    ..Adult moth preference and larval performance study were conducted on a novel host Lepidium latifolium L...
  47. Ernst E, Posadzki P, Lee M. Complementary and alternative medicine (CAM) for sexual dysfunction and erectile dysfunction in older men and women: an overview of systematic reviews. Maturitas. 2011;70:37-41 pubmed publisher
    ..For acupuncture and maca the evidence was insufficient for ED and SD respectively. It is concluded that there is some encouraging evidence but more and better studies are required to establish the value of CAM for SD and ED. ..
  48. Paul S. Identification and characterization of microRNAs and their targets in high-altitude stress-adaptive plant maca (Lepidium meyenii Walp). 3 Biotech. 2017;7:103 pubmed publisher
    ..In this study using recently published draft genome sequence of a high-altitude plant maca (Lepidium meyenii Walp) and applying genome-wide computational-based approaches, a total of 62 potentially conserved miRNAs ..
  49. Lee M, Lee H, You S, Ha K. The use of maca (Lepidium meyenii) to improve semen quality: A systematic review. Maturitas. 2016;92:64-69 pubmed publisher
    The aim of this review was to assess the evidence for the effectiveness of maca (Lepidium meyenii) in improving semen quality...
  50. Gonzales G, Gonzales C, Gonzales Castañeda C. Lepidium meyenii (Maca): a plant from the highlands of Peru--from tradition to science. Forsch Komplementmed. 2009;16:373-80 pubmed publisher
    This review summarizes the current state of knowledge on Lepidium meyenii (maca), a cruciferous plant (Brassicaceae family) which is cultivated exclusively at an altitude of 4,000-4,500 m in the Peruvian Central Andes...
  51. Fan C, Ge F. [Study on Chemical Constituents of Fat-soluble Extraction from Lepidium meyenii]. Zhong Yao Cai. 2015;38:318-22 pubmed
    To study the chemical constituents of the fat-soluble extraction from Lepidium meyenii root. Different extraction methods were studied, including supercritical carbon dioxide extraction, circumfluence extraction and steam distillation...
  52. Wang S, Shi P, Qu L, Ruan J, Yang S, Yu H, et al. Bioactive Constituents Obtained from the Seeds of Lepidium apetalum Willd. Molecules. 2017;22: pubmed publisher
    ..b>3), together with twenty-two known ones (4-25) were obtained from the seeds of Lepidium apetalum Willd...
  53. Visioli G, Conti F, Menta C, Bandiera M, Malcevschi A, Jones D, et al. Assessing biochar ecotoxicology for soil amendment by root phytotoxicity bioassays. Environ Monit Assess. 2016;188:166 pubmed publisher
    ..5, 1, 2, 5, 10, 20, 50% w/w) on both germination and root elongation of Cucumis sativus L., Lepidium sativum L. and Sorghum saccharatum Moench...
  54. Sun Z, Li F. [Studies on the leaf epidermal features of Lepidium (Brassicaceae) from China]. Zhong Yao Cai. 2007;30:780-5 pubmed
    ..Leaf epidermal mi-cromophology of 10 species of Lepidium from China were observed by using LM (light microscope) and SEM (scaning electron microscope)...
  55. Lee J, Mummenhoff K, Bowman J. Allopolyploidization and evolution of species with reduced floral structures in Lepidium L. (Brassicaceae). Proc Natl Acad Sci U S A. 2002;99:16835-40 pubmed
    ..b>Lepidium is the genus with the largest variation in floral structure in Brassicaceae, a family in which the floral ground ..
  56. Gonzales G, Valerio L. Medicinal plants from Peru: a review of plants as potential agents against cancer. Anticancer Agents Med Chem. 2006;6:429-44 pubmed
    ..are three plant materials endemic to Peru with the common names of Cat's claw (Uncaria tomentosa), Maca (Lepidium meyenii), and Dragon's blood (Croton lechleri) each having been scientifically investigated for a wide range of ..
  57. Staerfl S, Soliva C, Leiber F, Kreuzer M. Fatty acid profile and oxidative stability of the perirenal fat of bulls fattened on grass silage and maize silage supplemented with tannins, garlic, maca and lupines. Meat Sci. 2011;89:98-104 pubmed publisher
    ..Overall, supplementation was not efficient in improving carcass fat properties of maize-silage fed bulls. ..
  58. Davies L, Novais J, Martins Dias S. Influence of salts and phenolic compounds on olive mill wastewater detoxification using superabsorbent polymers. Bioresour Technol. 2004;95:259-68 pubmed
    ..The phytotoxicity was assessed by the germination of Lepidium sativum. Inhibition in plant growth occurred for all OMW dilutions without superabsorbent polymers application...
  59. McKay D. Nutrients and botanicals for erectile dysfunction: examining the evidence. Altern Med Rev. 2004;9:4-16 pubmed
    ..Improvements in penile endothelial L-arginine-nitric oxide activity appear to be a unifying explanation for the actions of these naturally occurring agents. ..
  60. Zhao J, Avula B, Chan M, Clément C, Kreuzer M, Khan I. Metabolomic differentiation of maca (Lepidium meyenii) accessions cultivated under different conditions using NMR and chemometric analysis. Planta Med. 2012;78:90-101 pubmed publisher
    ..on the effects of color type, cultivation history, and growing site on the composition alterations of maca (Lepidium meyenii Walpers) hypocotyls, NMR profiling combined with chemometric analysis was applied to investigate the ..
  61. Diaz P, Cardenas H, Orihuela P. Red Maca (Lepidium meyenii) did not affect cell viability despite increased androgen receptor and prostate-specific antigen gene expression in the human prostate cancer cell line LNCaP. Andrologia. 2016;48:922-6 pubmed publisher
    We examined whether aqueous extract of Lepidium meyenii (red Maca) could inhibit growth, potentiate apoptotic activity of two anticancer drugs Taxol and 2-methoxyestradiol (2ME) or change mRNA expression for the androgen target genes, ..
  62. Hagner M, Romantschuk M, Penttinen O, Egfors A, Marchand C, Augustsson A. Assessing toxicity of metal contaminated soil from glassworks sites with a battery of biotests. Sci Total Environ. 2018;613-614:30-38 pubmed publisher
    ..applied to assess the toxicity of the glassworks soil environments: a test of phytotoxicity with garden cress (Lepidium sativum); the BioTox™ test for toxicity to bacteria using Vibrio fischeri; and analyses of abundancies and ..
  63. De Feo V, De Martino L, Quaranta E, Pizza C. Isolation of phytotoxic compounds from tree-of-heaven (Ailanthus altissima swingle). J Agric Food Chem. 2003;51:1177-80 pubmed
    ..cv. "Saxa"), garden cress (Lepidium sativum L.), and purslane (Portulaca oleracea L.) seeds...
  64. Lee J, Baum S, Alvarez J, Patel A, Chitwood D, Bowman J. Activation of CRABS CLAW in the Nectaries and Carpels of Arabidopsis. Plant Cell. 2005;17:25-36 pubmed
    ..These MADS box proteins may provide general floral factors that must work in conjunction with specific factors in the activation of CRC in the nectaries and carpels. ..
  65. Akhtar N, Miller M, Haqqi T. Effect of a Herbal-Leucine mix on the IL-1?-induced cartilage degradation and inflammatory gene expression in human chondrocytes. BMC Complement Altern Med. 2011;11:66 pubmed publisher
    ..b>Lepidium meyenii and L-Leucine on the IL-1?-induced production of nitric oxide (NO), glycosaminoglycan (GAG), matrix ..
  66. Wu H, Kelley C, Pino Figueroa A, Vu H, Maher T. Macamides and their synthetic analogs: evaluation of in vitro FAAH inhibition. Bioorg Med Chem. 2013;21:5188-97 pubmed publisher
    Maca (Lepidium meyenii), a traditional food crop of the Peruvian Andes is now widely touted as a dietary supplement...
  67. Heim M, Wappelhorst O, Markert B. Thallium in terrestrial environments--occurrence and effects. Ecotoxicology. 2002;11:369-77 pubmed
    ..The LOEC for thallium in bioassays with terrestrial invertebrates and plants in artificial soil ranged from 1 to 500 mg/kg, which indicates an toxicity of thallium up to 100 times higher than that of Cadmium. ..
  68. Valdivia Cuya M, Yarasca De La Vega K, Lévano Sánchez G, Vásquez Cavero J, Temoche García H, Torres Torres L, et al. Effect of Lepidium meyenii (maca) on testicular function of mice with chemically and physically induced subfertility. Andrologia. 2016;48:927-34 pubmed publisher
    The aim of this study was to evaluate the effect of Lepidium meyenii (maca) in chemically and physically subfertile mice...
  69. Davies L, Novais J, Martins Dias S. Detoxification of olive mill wastewater using superabsorbent polymers. Environ Technol. 2004;25:89-100 pubmed
    ..in SAP2 with polyphenol concentrations up to 200 mg l(-1) revealed no phytotoxicity, and even stimulated Lepidium sativum growth, while olive mill wastewater without superabsorbent polymer revealed growth inhibition for all ..
  70. Brinckmann J, Smith E. Maca culture of the Junín Plateau. J Altern Complement Med. 2004;10:426-30 pubmed
  71. Tayel A, Moussa S, Salem M, Mazrou K, El Tras W. Control of citrus molds using bioactive coatings incorporated with fungal chitosan/plant extracts composite. J Sci Food Agric. 2016;96:1306-12 pubmed publisher
    ..digitatum and P. italicum, using in vitro qualitative and quantitative assays...
  72. Hosseini S, Abdul Aziz H. Evaluation of thermochemical pretreatment and continuous thermophilic condition in rice straw composting process enhancement. Bioresour Technol. 2013;133:240-7 pubmed publisher
    ..33%, respectively. The results of this study suggest that the application of chemical-biological integrated processes under thermophilic conditions is a novel method for the rapid degradation and maturation of rice straw residue...
  73. Laurinavicius R, Svegzdiene D, Gaina V. Force sensitivity of plant gravisensing. Adv Space Res. 2001;27:899-906 pubmed
  74. Ganzera M, Zhao J, Muhammad I, Khan I. Chemical profiling and standardization of Lepidium meyenii (Maca) by reversed phase high performance liquid chromatography. Chem Pharm Bull (Tokyo). 2002;50:988-91 pubmed
    b>Lepidium meyenii (Maca) is one of the few plants that can be cultivated in the harsh climate of the Andes...
  75. Gonzales G, Nieto J, Rubio J, Gasco M. Effect of Black maca (Lepidium meyenii) on one spermatogenic cycle in rats. Andrologia. 2006;38:166-72 pubmed
    b>Lepidium meyenii (Maca) grows exclusively between 4000 and 4500 m above sea level in the Peruvian central Andes. The hypocotyls of this plant are traditionally used in the Andean region for their supposed fertility-enhancing properties...
  76. Zevallos Concha A, Nunez D, Gasco M, Vasquez C, Quispe M, Gonzales G. Effect of gamma irradiation on phenol content, antioxidant activity and biological activity of black maca and red maca extracts (Lepidium meyenii walp). Toxicol Mech Methods. 2016;26:67-73 pubmed publisher
    ..DPPH) radical-scavenging activities and in vivo biological activities of red and black maca extracts (Lepidium meyenii)...
  77. Ohta Y, Yoshida K, Kamiya S, Kawate N, Takahashi M, Inaba T, et al. Feeding hydroalcoholic extract powder of Lepidium meyenii (maca) increases serum testosterone concentration and enhances steroidogenic ability of Leydig cells in male rats. Andrologia. 2016;48:347-54 pubmed publisher
    Although Lepidium meyenii (maca), a plant growing in Peru's central Andes, has been traditionally used for enhancing fertility and reproductive performance in domestic animals and human beings, effects of maca on reproductive organs are ..
  78. Mohammadi M, Koushki M, Ahmadian F, Moslemy M. The impact of home freezing on the sensory characteristics of ready-to-use leafy vegetables. J Sci Food Agric. 2011;91:519-22 pubmed publisher
    ..and the considerable impact of freezing on their sensory attributes, research was carried out to determine the best freezing temperature and storage time for a mixture of Allium ampeloprasum, Lepidium sativum and Stureia hortensis.
  79. Zhao J, Muhammad I, Dunbar D, Mustafa J, Khan I. New alkamides from maca (Lepidium meyenii). J Agric Food Chem. 2005;53:690-3 pubmed
    Maca (Lepidium meyenii) has been used as a food in Peru for thousands of years...
  80. Clement C, Kneubuhler J, Urwyler A, Witschi U, Kreuzer M. Effect of maca supplementation on bovine sperm quantity and quality followed over two spermatogenic cycles. Theriogenology. 2010;74:173-83 pubmed publisher
    Maca (Lepidium meyenii Walpers), is an Andean crop that grows between 3,800 and 4,500 m a.s.l...