heliotropium

Summary

Summary: A plant genus in the family Boraginaceae, order Lamiales, subclass Asteridae. This is the True Heliotrope that should not be confused with an unrelated plant sometimes called Garden Heliotrope (VALERIAN).

Top Publications

  1. Ogunbinu A, Flamini G, Cioni P, Adebayo M, Ogunwande I. Constituents of Cajanus cajan (L.) Millsp., Moringa oleifera Lam., Heliotropium indicum L. and Bidens pilosa L. from Nigeria. Nat Prod Commun. 2009;4:573-8 pubmed
    ..2%) and p-cymene (24.9%). On the other hand, aldehydes (52.8%) occurred in the highest amount in Heliotropium indicum, represented by phenylacetaldehyde (22.2%), (E)-2-nonenal (8.3%) and (E, Z)-2-nonadienal (6...
  2. Modak B, Contreras M, Gonzalez Nilo F, Torres R. Structure-antioxidant activity relationships of flavonoids isolated from the resinous exudate of Heliotropium sinuatum. Bioorg Med Chem Lett. 2005;15:309-12 pubmed
    Relationships between the structural characteristics of flavonoids isolated from the resinous exudate of Heliotropium sinuatum and their antioxidant activity were studied...
  3. Reddy J, Rao P, Reddy M. Wound healing effects of Heliotropium indicum, Plumbago zeylanicum and Acalypha indica in rats. J Ethnopharmacol. 2002;79:249-51 pubmed
    The ethanolic extracts of Heliotropium indicum, Plumbago zeylanicum and Acalypha indica were evaluated for their wound healing activity in rats...
  4. Muhaidat R, Sage T, Frohlich M, Dengler N, Sage R. Characterization of C?--C? intermediate species in the genus Heliotropium L. (Boraginaceae): anatomy, ultrastructure and enzyme activity. Plant Cell Environ. 2011;34:1723-36 pubmed publisher
    Photosynthetic pathway characteristics were studied in nine species of Heliotropium (sensu lato, including Euploca), using assessments of leaf anatomy and ultrastructure, activities of PEP carboxylase and C? acid decarboxylases, and ..
  5. Modak B, Salina M, Rodilla J, Torres R. Study of the chemical composition of the resinous exudate isolated from Heliotropium sclerocarpum and evaluation of the antioxidant properties of the phenolic compounds and the resin. Molecules. 2009;14:4625-33 pubmed publisher
    b>Heliotropium sclerocarpum Phil. (Heliotropiaceae) is a resinous bush that grows in the Atacama of northern Chile. The chemical composition of its resinous exudate was analyzed for the first time...
  6. Sharma S, Goyal N. Protective effect of Heliotropium eichwaldi against cisplatin-induced nephrotoxicity in mice. Zhong Xi Yi Jie He Xue Bao. 2012;10:555-60 pubmed
    The aim of the present study was to evaluate the nephroprotective effect of methanolic extract of Heliotropium eichwaldii (MHE) in mice with cisplatin-induced acute renal damage.
  7. Kulkarni Almeida A, Suthar A, Goswami H, Vishwakarma R, Chauhan V, Balakrishnan A, et al. Novel leads from Heliotropium ovalifolium, 4,7,8-trimethoxy-naphthalene-2-carboxylic acid and 6-hydroxy-5,7-dimethoxy-naphthalene-2-carbaldehyde show specific IL-6 inhibitory activity in THP-1 cells and primary human monocytes. Phytomedicine. 2008;15:1079-86 pubmed publisher
    From our screening program, we identified the anti-inflammatory effects of the extracts of Heliotropium ovalifolium in its ability to inhibit specific cytokines. The H...
  8. Vogan P, Frohlich M, Sage R. The functional significance of C3-C4 intermediate traits in Heliotropium L. (Boraginaceae): gas exchange perspectives. Plant Cell Environ. 2007;30:1337-45 pubmed
    We demonstrate for the first time the presence of species exhibiting C3-C4 intermediacy in Heliotropium (sensu lato), a genus with over 100 C3 and 150 C4 species...
  9. Murugesh K, Yeligar V, Dash D, Sengupta P, Maiti B, Maity T. Antidiabetic, antioxidant and antihyperlipidemic status of Heliotropium zeylanicum extract on streptozotocin-induced diabetes in rats. Biol Pharm Bull. 2006;29:2202-5 pubmed
    The potential role of the methanolic extract of Heliotropium zeylanicum (BURM.F) LAMK (MEHZ) in the treatment of diabetes along with its antioxidant and antihyperlipidemic effects was studied in streptozotocin-induced diabetic rats...

More Information

Publications56

  1. Kyei S, Koffuor G, Ramkissoon P, Afari C, Asiamah E. The Claim of Anti-Cataract Potential of Heliotropium indicum: A Myth or Reality?. Ophthalmol Ther. 2015;4:115-28 pubmed publisher
    b>Heliotropium indicum has several uses in traditional medicine attributable to its numerous bioactive compounds. It is used as a traditional remedy for cataracts in Ghana without any scientific verification...
  2. Bibi T, Ahmad M, Mohammad Tareen N, Jabeen R, Sultana S, Zafar M, et al. The endemic medicinal plants of Northern Balochistan, Pakistan and their uses in traditional medicine. J Ethnopharmacol. 2015;173:1-10 pubmed publisher
    ..Allium baluchistanicum and Viola makranica, (8 UR each), and least use report were calculated for two species Heliotropium remotiflorum and Tetracme stocksii (1 UR for each)...
  3. Pathania S, Ramakrishnan S, Bagler G. Phytochemica: a platform to explore phytochemicals of medicinal plants. Database (Oxford). 2015;2015: pubmed publisher
    ..Atropa belladonna, Catharanthus roseus, Heliotropium indicum, Picrorhiza kurroa and Podophyllum hexandrum are important Himalayan medicinal plants, reported to have ..
  4. Hassannejad S, Pirouie M, Haghi D. RELATIONSHIPS BETWEEN SOME SOIL PARAMETERS AND WEED COMMUNITY (CASE STUDY: WINTER WHEAT FIELDS OF UREMIA-IRAN). Commun Agric Appl Biol Sci. 2015;80:279-87 pubmed
    ..Malva neglecta Wallr., Portulaca oleracea L., Sisymbrium irio L., Atriplex patulum (L.). Aellen., and Heliotropium europaeum L. had maximum correlation with soil's pH. Euphorbia peplus L. and Salvia spinosa L...
  5. Valenzuela B, Rodriguez F, Modak B, Imarai M. Alpinone exhibited immunomodulatory and antiviral activities in Atlantic salmon. Fish Shellfish Immunol. 2018;74:76-83 pubmed publisher
    ..of two flavonoids, Alpinone and Pinocembrine, which were isolated and purified from resinous exudates of Heliotropium huascoense and Heliotropium sinuatum, respectively...
  6. Singh B, Sahu P, Sharma R. Flavonoids from Heliotropium subulatum exudate and their evaluation for antioxidant, antineoplastic and cytotoxic activities II. Cytotechnology. 2017;69:103-115 pubmed publisher
    ..The main objective of this study was to test dichloromethane fraction of resinous exudate of Heliotropium subulatum for their antioxidant, antineoplastic and cytotoxic activities, as well as to search new antioxidant ..
  7. Khurm M, Chaudhry B, Uzair M, Janbaz K. Antimicrobial, Cytotoxic, Phytotoxic and Antioxidant Potential of Heliotropium strigosum Willd. Medicines (Basel). 2016;3: pubmed publisher
    b>Background:Heliotropium strigosum Willd. (Chitiphal) is a medicinally important herb that belongs to the Boraginaceae family...
  8. Muller A, Griswold T. Osmiine bees of the genus <i>Haetosmia</i> (Megachilidae, Osmiini): biology, taxonomy and key to species. Zootaxa. 2017;4358:351-364 pubmed publisher
    ..The females of all six Haetosmia species collect pollen from the narrow-tubed flowers of Heliotropium (Boraginaceae) with the aid of specialized pollen-harvesting bristles on the proboscis...
  9. Kyei S, Koffuor G, Ramkissoon P, Abu E, Sarpong J. Anti-Cataract Potential of Heliotropium indicum Linn on Galactose-Induced Cataract in Sprague-Dawley Rats. Curr Eye Res. 2017;42:394-401 pubmed publisher
    To evaluate the anti-cataract potential of an aqueous whole plant extract of Heliotropium indicum (HIE) on galactose-induced cataract in Sprague-Dawley rats.
  10. Sadeq M, Pathak M, Salih A, Abido M, AbaHussain A. In Vitro Regeneration of Endangered Medicinal Plant Heliotropium kotschyi (Ramram). Methods Mol Biol. 2016;1391:103-12 pubmed publisher
    b>Heliotropium kotschyi (Ramram) is an important endangered medicinal plant distributed in the Kingdom of Bahrain. Plant tissue culture technique is applied for ex situ conservation study...
  11. Peterson J, Payne A, Culvenor C. Heliotropium europaeum poisoning of sheep with low liver copper concentrations and the preventive efficacy of cobalt and antimethanogen. Aust Vet J. 1992;69:51-6 pubmed
    In a field experiment in the Mallee district of Victoria, Merlno xBorder Leicester ewes and wethers grazed Heliotropium europaeum (heliotrope) over periods of 3 to 4 months in 4 successive years...
  12. Singh B, Sharma R. Anti-Inflammatory and Antimicrobial Properties of Flavonoids from Heliotropium subulatum Exudate. Inflamm Allergy Drug Targets. 2015;14:125-32 pubmed
    b>Heliotropium subulatum is an erect or procumbent perennial herb; leaves contain foliar trichomes and its resinous exudate is used in traditional medicine...
  13. Jain S, Singh B, Jain R. Antimicrobial activity of triterpenoids from Heliotropium ellipticum. Fitoterapia. 2001;72:666-8 pubmed
    ..Seven sterols and triterpenoids have been isolated from H. ellipticum and tested for their antimicrobial activity...
  14. Abdulghader K, Nojavan M, Naghshbandi N. Chemical stress induced by heliotrope (Heliotropium europaeum L.) allelochemicals and increased activity of antioxidant enzymes. Pak J Biol Sci. 2008;11:915-9 pubmed
    ..These finding shows that the chemical stress induced by leaf extract produces super oxide (O2*) and H2O2, which is neutralized to H2O and O2 by these enzymes...
  15. Firdous S, Ansari N, Fatima I, Malik A, Afza N, Iqbal L, et al. Ophiamides A-B, new potent urease inhibitory sphingolipids from Heliotropium ophioglossum. Arch Pharm Res. 2012;35:1133-7 pubmed publisher
    ..new sphingolipids have been isolated from the n-hexane subfraction of the MeOH extract of the whole plant of Heliotropium ophioglossum along with glycerol monopalmitate (3) and ?-sitosterol 3-O-?-D: -glucoside (4) reported for the ..
  16. Macias F, Simonet A, D Abrosca B, Maya C, Reina M, González Coloma A, et al. Megalanthine, a bioactive sesquiterpenoid from Heliotropium megalanthum, its degradation products and their bioactivities. J Chem Ecol. 2009;35:39-49 pubmed publisher
    ..named megalanthine, was isolated from the resinous exudates of Heliotropium megalanthum. The degradation products of this compound were identified...
  17. Guilet D, Guntern A, Ioset J, Queiroz E, Ndjoko K, Foggin C, et al. Absolute configuration of a tetrahydrophenanthrene from Heliotropium ovalifolium by LC-NMR of its Mosher esters. J Nat Prod. 2003;66:17-20 pubmed
    ..heliophenanthrone)) has been isolated from the aerial parts of Heliotropium ovalifolium...
  18. Deol H, Howell J, Dorling P, Symonds H. The effect of copper and heliotrope on the composition of bile in sheep. Res Vet Sci. 1992;53:324-30 pubmed
    ..Increasing the intake of copper increased the rate of excretion of copper in bile. Copper output was lower when heliotrope was fed alone...
  19. Rossi F, Jullian V, Pawlowiez R, Kumar Roine S, Haddad M, Darius H, et al. Protective effect of Heliotropium foertherianum (Boraginaceae) folk remedy and its active compound, rosmarinic acid, against a Pacific ciguatoxin. J Ethnopharmacol. 2012;143:33-40 pubmed publisher
    Senescent leaves of Heliotropium foertherianum Diane & Hilger (Boraginaceae) are traditionally used in the Pacific region to treat Ciguatera Fish Poisoning...
  20. Al Qurainy F, Khan S, Nadeem M, Tarroum M, Alaklabi A. Assessment of phylogenetic relationship of rare plant species collected from Saudi Arabia using internal transcribed spacer sequences of nuclear ribosomal DNA. Genet Mol Res. 2013;12:723-30 pubmed publisher
    ..Two rare plant species viz, Heliotropium strigosum claded with H. pilosum (98% branch support) and Pancratium tortuosum claded with P...
  21. Guntern A, Ioset J, Queiroz E, Sandor P, Foggin C, Hostettmann K. Heliotropamide, a novel oxopyrrolidine-3-carboxamide from Heliotropium ovalifolium. J Nat Prod. 2003;66:1550-3 pubmed
    ..central moiety, has been isolated as the major product of the dicholoromethane extract of Heliotropium ovalifolium aerial parts...
  22. Abdel Sattar E, Maes L, Salama M. In vitro activities of plant extracts from Saudi Arabia against malaria, leishmaniasis, sleeping sickness and Chagas disease. Phytother Res. 2010;24:1322-8 pubmed publisher
    ..50 microg/mL in the absence of toxicity against MRC-5 cell line (CC(50) > 30 microg/mL). Heliotropium curassavicum (CHCl(3) fraction) showed similar activity against P. falciparum (IC(50) 0...
  23. Eroksuz Y, Eroksuz H, Ozer H, Canatan H, Yaman I, Cevik A. Toxicity of dietary Heliotropium dolosum seed to broiler chickens. Vet Hum Toxicol. 2001;43:334-8 pubmed
    Five groups of 20 female broiler chicks were fed different levels of dehulled Heliotropium dolosum seed (w/w%; 0.0, 1.0, 3.0, 5.0 or 10.0%) from 10 to 52 d of age...
  24. Eroksuz Y, Eroksuz H, Ozer H, Ilhan N, Cevik A, Yaman I, et al. Toxicity of dietary Heliotropium dolosum seed to Japanese quail. Vet Hum Toxicol. 2002;44:264-8 pubmed
    ..However, the resistance to H dolosum is less than Senecio Jacobae and Crotalaria spectabilis when considering tissue injury...
  25. Modak B, Rojas M, Torres R, Rodilla J, Luebert F. Antioxidant activity of a new aromatic geranyl derivative of the resinous exudates from Heliotropium glutinosum Phil. Molecules. 2007;12:1057-63 pubmed
    b>Heliotropium glutinosum Phil. (Heliotropiceae) is a resinous bush that grows at a height of 2000 m in Chañaral, Chile. From the resinous exudates of Heliotropium glutinosum Phil...
  26. Modak B, Torres R, Lissi E, Delle Monache F. Antioxidant capacity of flavonoids and a new arylphenol of the resinous exudate from Heliotropium sinuatum. Nat Prod Res. 2003;17:403-7 pubmed
    From the resinous exudate of Heliotropium sinuatum (family Boraginaceae), a new compound: 4-(3',5'-dihydroxynonadecyl)phenol 1, together with eight previously described flavonoids, were isolated and their antioxidant activities were ..
  27. Valenzuela B, Obreque J, Soto Aguilera S, Maisey K, Imarai M, Modak B. Key cytokines of adaptive immunity are differentially induced in rainbow trout kidney by a group of structurally related geranyl aromatic derivatives. Fish Shellfish Immunol. 2016;49:45-53 pubmed publisher
    Filifolinone is a semi-synthetic terpenoid derivative obtained from Heliotropium filifolium that increases the expression level of pro-inflammatory and anti-inflammatory cytokines in kidney cells of salmon...
  28. Satyavani K, Dheepak V, Gurudeeban S, Ramanathan T. Direct organogenesis of seaside heliotrope (Heliotropium crassavicum) using stem explants. Pak J Biol Sci. 2013;16:1216-9 pubmed
    b>Heliotropium crassavicum L. is a sand binder salt marsh herb with enormous traditional value and widely found in South Asia America and Europe...
  29. Togola A, Diallo D, Dembélé S, Barsett H, Paulsen B. Ethnopharmacological survey of different uses of seven medicinal plants from Mali, (West Africa) in the regions Doila, Kolokani and Siby. J Ethnobiol Ethnomed. 2005;1:7 pubmed
    ..The plants were Opilia celtidifolia, Anthocleista djalonensis, Erythrina senegalensis, Heliotropium indicum, Trichilia emetica, Piliostigma thonningii and Cochlospermum tinctorium...
  30. Howell J, Deol H, Dorling P, Thomas J. Experimental copper and heliotrope intoxication in sheep: morphological changes. J Comp Pathol. 1991;105:49-74 pubmed
  31. Chauvin P, Dillon J, Moren A. [An outbreak of Heliotrope food poisoning, Tadjikistan, November 1992-March 1993]. Sante. 1994;4:263-8 pubmed
    The seeds and roots of Heliotropium lasocarpium, contain a pyrrolizidine alkaloid which causes toxic liver injury and veno-occlusive disease (VOD), characterised by an occlusive lesion of the centrolobular veins of the liver, when ..
  32. Ghaffari M, Chaudhary B, Uzair M, Ashfaq K. CYTOTOXIC, ?-CHYMOTRYPSIN AND UREASE INHIBITION ACTIVITIES OF THE PLANT Heliotropium dasycarpum L. Afr J Tradit Complement Altern Med. 2016;13:194-198 pubmed publisher
    The aim of this study was to investigate Cytotoxic, ?-Chymotrypsin and Urease inhibition activities of the plant Heliotropium dasycarpum.
  33. Harris D, Nowara G. The characteristics and causes of sheep losses in the Victorian Mallee. Aust Vet J. 1995;72:331-40 pubmed
    ..blowfly strike (especially in Merino sheep and weaners), ewe losses in autumn close to lambing, and heliotrope (Heliotropium europaeum) poisoning...
  34. Eroksuz H, Eroksuz Y, Ozer H, Ceribasi A, Tosun F, Tamer U, et al. Toxicity of dietary Heliotropium circinatum to rats. Vet Hum Toxicol. 2003;45:198-201 pubmed
    ..alkaloid intoxication was produced in adult, male rats by feeding different levels (0, 1, 3, 5 or 10%) of Heliotropium circinatum for 20 w. Combined GC-MS revealed 0...
  35. Modak B, Rojas M, Torres R. Chemical analysis of the resinous exudate isolated from Heliotropium taltalense and evaluation of the antioxidant activity of the phenolics components and the resin in homogeneous and heterogeneous systems. Molecules. 2009;14:1980-9 pubmed publisher
    ..The initial velocity reactions for the pure compounds and for the extract were higher in SDS media than in ethanolic solution. The velocity of reaction observed was interpreted in terms of the reaction medium environment in the micelle...
  36. Modak B, Sandino A, Arata L, Cárdenas Jirón G, Torres R. Inhibitory effect of aromatic geranyl derivatives isolated from Heliotropium filifolium on infectious pancreatic necrosis virus replication. Vet Microbiol. 2010;141:53-8 pubmed publisher
    ..of a group of natural compounds (geranyl aromatic derivatives) isolated from the resinous exudate of the plant Heliotropium filifolium (Heliotropiaceae), semi-synthetics compounds obtained from them, and the resinous exudate, on CHSE-..
  37. Valenzuela B, Imarai M, Torres R, Modak B. Immunomodulatory effects of the aromatic geranyl derivative filifolinone tested by the induction of cytokine expression. Dev Comp Immunol. 2013;41:675-82 pubmed publisher
    ..We evaluated the immunostimulant activity of terpenoid derivatives isolated from species of the Heliotropium genus, which had previously shown antiviral activity in salmon...
  38. Urzua A, Echeverría J, Rezende M, Wilkens M. Antibacterial properties of 3 H-spiro[1-benzofuran-2,1'-cyclohexane] derivatives from Heliotropium filifolium. Molecules. 2008;13:2385-93 pubmed
    A re-examination of cuticular components of Heliotropium filifolium allowed the isolation of four new compounds: 3'-hydroxy-2',2',6'-trimethyl-3H-spiro[1-benzo-furan-2,1'-cyclohexane]-5-carboxylic acid(2), methyl 3'-acetyloxy-2',2',6'-..
  39. Fu P, Xia Q, He X, Barel S, Edery N, Beland F, et al. Detection of Pyrrolizidine Alkaloid DNA Adducts in Livers of Cattle Poisoned with Heliotropium europaeum. Chem Res Toxicol. 2017;30:851-858 pubmed publisher
    ..5 months after their last exposure to the contaminated feed, suggesting that DHP-derived DNA adducts can serve as biomarkers for pyrrolizidine alkaloid exposure and poisoning...
  40. Deol H, Howell J, Dorling P. Effect of the ingestion of heliotrope and copper on the concentration of zinc, selenium and molybdenum in the liver of sheep. J Comp Pathol. 1994;110:303-7 pubmed
    ..The increase in liver Se may therefore have represented a passive or active response to liver necrosis, whereas effects on Zn and Mo represented specific metabolic disturbances attributable to heliotrope feeding...
  41. Luebert F, Hilger H, Weigend M. Diversification in the Andes: age and origins of South American Heliotropium lineages (Heliotropiaceae, Boraginales). Mol Phylogenet Evol. 2011;61:90-102 pubmed publisher
    ..In this paper we examine the hypothesis that the Andean South American groups of Heliotropium originated and diversified in response to Andean orogeny during the late Miocene and a the subsequent ..
  42. Dolui A, Debnath M. Antifeedant activity of plant extracts to an insect Helopeltis theivora. J Environ Biol. 2010;31:557-9 pubmed
    ..different solvent extracts (viz Petroleum ether Ethyl acetate and Methanol) obtained from leaves and flowers of Heliotropium indicum and Spilanthes calva were screened for antifeedant activity against Helopeltis theivora...
  43. Frohlich M. A simple, cheap, one-minute method to mount insect pins for use as sharp-tipped probes in plant dissection. J Electron Microsc (Tokyo). 2005;54:409-11 pubmed
    ..Insect pins, with their sharp points, are ideal for fine dissection of plants, especially of shoot tips and early developing flower buds. Twist mounting makes them convenient and effective dissecting tools to prepare specimens for SEM...
  44. Dolui A, Debnath M, De B, Kumar A. Reproductive activities of Heliotropium indicum isolate against Helopeltis theivora and toxicity evaluation in mice. J Environ Biol. 2012;33:603-7 pubmed
    A new compound E was isolated from the methanolic extract of the leaves of Heliotropium indicum by chromatographic fractionation. In the present study, the effect of the compound E on reproduction of Helopeltis theivora has been evaluated...
  45. Vogan P, Sage R. Effects of low atmospheric CO2 and elevated temperature during growth on the gas exchange responses of C3, C3-C4 intermediate, and C4 species from three evolutionary lineages of C4 photosynthesis. Oecologia. 2012;169:341-52 pubmed publisher
    ..Closely related C(3), C(3)-C(4), and C(4) species in the genera Flaveria, Heliotropium, and Alternanthera were grown near 380 and 180 ?mol CO(2) mol(-1) air and day/night temperatures of 37/29°C...
  46. Muñoz M, Urzua A, Echeverría J, Modak B, Joseph Nathan P. Solid state structure and absolute configuration of filifolinol acetate. Nat Prod Commun. 2011;6:759-62 pubmed
  47. Cai Y, Sarotti A, Gündisch D, Kondratyuk T, Pezzuto J, Turkson J, et al. Heliotropiumides A and B, new phenolamides with N-carbamoyl putrescine moiety from Heliotropium foertherianum collected in Hawaii and their biological activities. Bioorg Med Chem Lett. 2017;27:4630-4634 pubmed publisher
    ..an uncommon carbamoyl putrescine moiety, were isolated from the seeds of a naturalized Hawaiian higher plant, Heliotropium foertherianum Diane & Hilger in the borage family, which is widely used for the treatment of ciguatera fish ..