mahonia

Summary

Summary: A plant genus in the family BERBERIDACEAE. Oregon Grape was discovered in North America and classified by Pursh as a BERBERIS but Nuttall claimed it is different enough to call it a new genus, MAHONIA. Now botanists insist on Berberis while horticulturists stay with this genus. It is a source of BERBERINE.

Top Publications

  1. Cernáková M, Kost álová D, Kettmann V, Plodová M, Tóth J, Drimal J. Potential antimutagenic activity of berberine, a constituent of Mahonia aquifolium. BMC Complement Altern Med. 2002;2:2 pubmed
    ..natural resources, the purpose of this research was twofold: (1) to fractionate crude extracts from the bark of Mahonia aquifolium and (2) to evaluate the strength of the antimutagenic activity of the separate components against one ..
  2. Cernáková M, Kostalova D. Antimicrobial activity of berberine--a constituent of Mahonia aquifolium. Folia Microbiol (Praha). 2002;47:375-8 pubmed
    The antimicrobial activity of the protoberberine alkaloid, berberine, isolated from Mahonia aquifolium, was evaluated against 17 microorganisms including two Gram-negative bacteria--Pseudomonas aeruginosa and Escherichia coli (both ..
  3. Slobodníková L, Kost álová D, Labudová D, Kotulová D, Kettmann V. Antimicrobial activity of Mahonia aquifolium crude extract and its major isolated alkaloids. Phytother Res. 2004;18:674-6 pubmed
    The crude extract of Mahonia aquifolium (Pursh) Nutt. stem bark and its two main protoberberine alkaloids, berberine and jatrorrhizine, were tested for their in vitro antimicrobial activity...
  4. Hu W, Yu L, Wang M. Antioxidant and antiproliferative properties of water extract from Mahonia bealei (Fort.) Carr. leaves. Food Chem Toxicol. 2011;49:799-806 pubmed publisher
    b>Mahonia bealei (Fort.) Carr. (Berberidaceae) leaves have been widely used as a tea leaf beverage south of the Qinling Mountains of China. In this study, the antioxidant and antiproliferative properties of M...
  5. Gulliver W, Donsky H. A report on three recent clinical trials using Mahonia aquifolium 10% topical cream and a review of the worldwide clinical experience with Mahonia aquifolium for the treatment of plaque psoriasis. Am J Ther. 2005;12:398-406 pubmed
    This monograph summarizes 3 recent clinical trials and the worldwide clinical experience with Mahonia aquifolium in patients with psoriasis...
  6. Chao J, Lu T, Liao J, Huang T, Lee M, Cheng H, et al. Analgesic and anti-inflammatory activities of ethanol root extract of Mahonia oiwakensis in mice. J Ethnopharmacol. 2009;125:297-303 pubmed publisher
    ..This study investigated the anti-inflammatory and analgesic activities, and protoberberine alkaloid contents of ethanol extract of MO roots (MOR(EtOH))...
  7. Klovekorn W, Tepe A, Danesch U. A randomized, double-blind, vehicle-controlled, half-side comparison with a herbal ointment containing Mahonia aquifolium, Viola tricolor and Centella asiatica for the treatment of mild-to-moderate atopic dermatitis. Int J Clin Pharmacol Ther. 2007;45:583-91 pubmed
    ..An ointment containing extracts from Mahonia aquifolium, Viola tricolor and Centella asiatica has previously been studied in open uncontrolled trials with ..
  8. Vollekova A, Kostalova D, Sochorova R. Isoquinoline alkaloids from Mahonia aquifolium stem bark are active against Malassezia spp. Folia Microbiol (Praha). 2001;46:107-11 pubmed
    Bioassay directed fractionation of crude extract from Mahonia aquifolium led to the isolation of fraction A (bisbenzylisoquinoline alkaloid complex, BBI) and a fraction of protoberberine alkaloids, where the major compounds berberine and ..
  9. Rackova L, Majekova M, Kost álová D, Stefek M. Antiradical and antioxidant activities of alkaloids isolated from Mahonia aquifolium. Structural aspects. Bioorg Med Chem. 2004;12:4709-15 pubmed
    The antioxidant activities of three alkaloids isolated from Mahonia aquifolium--berberine, jatrorrhizine, and magnoflorine--were studied with respect to their structural aspects, particularly the presence and the position of -OH groups, ..

More Information

Publications37

  1. Rohrer U, Kunz E, Lenkeit K, Schaffner W, Meyer J. Antimicrobial activity of Mahonia aquifolium and two of its alkaloids against oral bacteria. Schweiz Monatsschr Zahnmed. 2007;117:1126-31 pubmed
    Extracts or alkaloids isolated from Mahonia aquifolium exhibit antimicrobial activity against Gram-positive and Gram-negative bacteria, fungi, and protozoa. In this study the bacteriostatic and bacteriocidal activities of a M...
  2. Zeng X, Dong Y, Sheng G, Dong X, Sun X, Fu J. Isolation and structure determination of anti-influenza component from Mahonia bealei. J Ethnopharmacol. 2006;108:317-9 pubmed
    The fraction possessing anti-influenza activity, which is obtained from the roots of Mahonia bealei (Fort), has been studied regarding its chemical compositions and molecular structure...
  3. Wong B, Hsiao Y, Lin T, Chen K, Chen P, Kuo W, et al. The in vitro and in vivo apoptotic effects of Mahonia oiwakensis on human lung cancer cells. Chem Biol Interact. 2009;180:165-74 pubmed publisher
    Both the root and stem bark of Mahonia species were popular folk medicines. The plant has several proven biological activities including anti-bacterial, anti-fungal, and anti-inflammatory effects...
  4. Sun Y, Moore M, Zhang S, Soltis P, Soltis D, Zhao T, et al. Phylogenomic and structural analyses of 18 complete plastomes across nearly all families of early-diverging eudicots, including an angiosperm-wide analysis of IR gene content evolution. Mol Phylogenet Evol. 2016;96:93-101 pubmed publisher
    ..eudicots Buxus, Tetracentron, Trochodendron, Nelumbo, Platanus, Nandina, Megaleranthis, Ranunculus, Mahonia and Macadamia...
  5. Ma W, Li H, Dong C, He X, Guo C, Zhang C, et al. Palmatine from Mahonia bealei attenuates gut tumorigenesis in ApcMin/+ mice via inhibition of inflammatory cytokines. Mol Med Rep. 2016;14:491-8 pubmed publisher
    b>Mahonia bealei is a Chinese folk medicine used to treat various ailments, in particular gastrointestinal inflammation?related illnesses, and palmatine is one of its active constituents...
  6. Li G, Kusari S, Kusari P, Kayser O, Spiteller M. Endophytic Diaporthe sp. LG23 Produces a Potent Antibacterial Tetracyclic Triterpenoid. J Nat Prod. 2015;78:2128-32 pubmed publisher
    ..LG23, inhabiting leaves of the Chinese medicinal plant Mahonia fortunei. Six biosynthetically related known steroids were also isolated in parallel...
  7. Hu W, Wu L, Qiang Q, Ji L, Wang X, Luo H, et al. The dichloromethane fraction from Mahonia bealei (Fort.) Carr. leaves exerts an anti-inflammatory effect both in vitro and in vivo. J Ethnopharmacol. 2016;188:134-43 pubmed publisher
    b>Mahonia bealei has a long history of medical use in traditional Chinese medicine for the treatment of inflammatory-associated diseases...
  8. Farahnik B, Sharma D, Alban J, Sivamani R. Topical Botanical Agents for the Treatment of Psoriasis: A Systematic Review. Am J Clin Dermatol. 2017;18:451-468 pubmed publisher
    ..We found that the most highly studied and most efficacious topical botanical therapeutics were Mahonia aquifolium, indigo naturalis, aloe vera, and, to a lesser degree, capsaicin...
  9. Wang K, Chai L, Feng X, Liu Z, Liu H, Ding L, et al. Metabolites identification of berberine in rats using ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry. J Pharm Biomed Anal. 2017;139:73-86 pubmed publisher
    ..Phellodendron chinense Schneid., and Mahonia bealei (Fort.) Carr...
  10. Kaufmann D, Kaur Dogra A, Tahrani A, Herrmann F, Wink M. Extracts from Traditional Chinese Medicinal Plants Inhibit Acetylcholinesterase, a Known Alzheimer's Disease Target. Molecules. 2016;21: pubmed publisher
    ..All three extracts of Berberis bealei (formerly Mahonia bealei), Coptis chinensis and Phellodendron chinense, which contain numerous isoquinoline alkaloids, ..
  11. Wang Z, Wang N, Liu X, Wang Q, Xu B, Liu P, et al. Broadleaf Mahonia attenuates granulomatous lobular mastitis?associated inflammation by inhibiting CCL?5 expression in macrophages. Int J Mol Med. 2018;41:340-352 pubmed publisher
    ..Broadleaf Mahonia (BM) is a traditional Chinese herb that is believed to have anti?inflammatory properties according to ancient ..
  12. Wang L, Ci X, Lv H, Wang X, QIN F, Cheng G. Isotetrandrine ameliorates tert-butyl hydroperoxide-induced oxidative stress through upregulation of heme oxygenase-1 expression. Exp Biol Med (Maywood). 2016;241:1568-76 pubmed publisher
    1R, 1'S-isotetrandrine, a naturally occurring plant alkaloid found in Mahonia of Berberidaceae, possesses anti-inflammatory, antibacterial, and antiviral properties, but the antioxidative activity and mechanism action remain unclear...
  13. Gođevac D, Damjanovic A, Stanojkovic T, Anđelković B, Zdunic G. Identification of cytotoxic metabolites from Mahonia aquifolium using 1H NMR-based metabolomics approach. J Pharm Biomed Anal. 2018;150:9-14 pubmed publisher
    Herein, we propose a 1H NMR-based metabolomics method to reveal cytotoxic metabolites from Mahonia aquifolium stem-bark...
  14. Wyka T, Karolewski P, Żytkowiak R, Chmielarz P, Oleksyn J. Whole-plant allocation to storage and defense in juveniles of related evergreen and deciduous shrub species. Tree Physiol. 2016;36:536-47 pubmed publisher
    ..We selected three species pairs consisting of an evergreen and a related deciduous species: Mahonia aquifolium (Pursh) Nutt. and Berberis vulgaris L. (Berberidaceae), Prunus laurocerasus L...
  15. Mongélard G, Seemann M, Boisson A, Rohmer M, Bligny R, Rivasseau C. Measurement of carbon flux through the MEP pathway for isoprenoid synthesis by (31)P-NMR spectroscopy after specific inhibition of 2-C-methyl-d-erythritol 2,4-cyclodiphosphate reductase. Effect of light and temperature. Plant Cell Environ. 2011;34:1241-7 pubmed publisher
    ..The MEP pathway metabolic flux was determined in spinach (Spinacia oleracea), pea (Pisum sativum), Oregon grape (Mahonia aquifolium) and boxwood (Buxus sempervirens) leaves...
  16. Hajnická V, Kost álová D, Svecová D, Sochorova R, Fuchsberger N, Tóth J. Effect of Mahonia aquifolium active compounds on interleukin-8 production in the human monocytic cell line THP-1. Planta Med. 2002;68:266-8 pubmed
    The effect of the crude extract and of two alkaloid fractions prepared from Mahonia aquifolium on interleukin-8 (IL-8) production in the lipopolysaccharide (LPS)-stimulated human monocytic cell line THP-1 was studied...
  17. Deng S, May B, Zhang A, Lu C, Xue C. Plant extracts for the topical management of psoriasis: a systematic review and meta-analysis. Br J Dermatol. 2013;169:769-82 pubmed publisher
    ..The 12 included studies investigated extracts of: Mahonia aquifolium (n = 5), Aloe vera (n = 3), indigo naturalis (n = 2), kukui nut oil (n = 1) and Camptotheca ..
  18. Wang T, Yang X. Reversal effect of isotetrandrine, an isoquinoline alkaloid extracted from Caulis Mahoniae, on P-glycoprotein-mediated doxorubicin-resistance in human breast cancer (MCF-7/DOX) cells. Yao Xue Xue Bao. 2008;43:461-6 pubmed
    ..In conclusion, isotetrandrine exhibited potent effect on the reversal of P-gp-mediated MDR in vitro, suggesting that it might become a candidate of effective MDR reversing agent in cancer chemotherapy...
  19. Vollekova A, Kost álová D, Kettmann V, Tóth J. Antifungal activity of Mahonia aquifolium extract and its major protoberberine alkaloids. Phytother Res. 2003;17:834-7 pubmed
    The crude extract of Mahonia aquifolium (Berberidaceae) stem bark and its components berberine, palmatine and jatrorrhizine were screened for their inhibitory activity against a variety of dermatophytes and two Candida species of human ..
  20. Ma J, Yang B, Zhu W, Sun L, Tian J, Wang X. The complete chloroplast genome sequence of Mahonia bealei (Berberidaceae) reveals a significant expansion of the inverted repeat and phylogenetic relationship with other angiosperms. Gene. 2013;528:120-31 pubmed publisher
    b>Mahonia bealei (Berberidaceae) is a frequently-used traditional Chinese medicinal plant with efficient anti-inflammatory ability. This plant is one of the sources of berberine, a new cholesterol-lowering drug with anti-diabetic activity...
  21. Liu S, Liu B, He K, Lin X, Lu W. [Analysis of essential oil from Mahonia duclouxiana]. Zhong Yao Cai. 2010;33:1099-102 pubmed
    To analyze the compositions of essential oil from Mahonia duclouxiana.
  22. Chao J, Lee M, Amagaya S, Liao J, Wu J, Ho L, et al. Hepatoprotective effect of shidagonglao on acute liver injury induced by carbon tetrachloride. Am J Chin Med. 2009;37:1085-97 pubmed
    ..These experimental results suggest that SDGL(EtOH) can attenuate CCl(4)-induced acute liver injury in rats...
  23. Zeng X, Lao B, Dong X, Sun X, Dong Y, Sheng G, et al. [Study on anti-influenza effect of alkaloids from roots of Mahonia bealei in vitro]. Zhong Yao Cai. 2003;26:29-30 pubmed
    Anti-influenza effect of alkaloids from roots of Mahonia bealei (Fort.) Carr. was studied in vitro. The experiment in embryo indicated that the alkaloids at concentration of 0...
  24. He J, Mu Q. The medicinal uses of the genus Mahonia in traditional Chinese medicine: An ethnopharmacological, phytochemical and pharmacological review. J Ethnopharmacol. 2015;175:668-83 pubmed publisher
    Plants of the genus Mahonia Nuttall (Berberidaceae) have a long history of medical use in Traditional Chinese Medicine (TCM) for the treatment of a wide range of health disorders, such as tuberculosis, periodontitis, dysentery, ..
  25. Huang J, Su T, Lebereton Anberrée J, Zhang S, Zhou Z. The oldest Mahonia (Berberidaceae) fossil from East Asia and its biogeographic implications. J Plant Res. 2016;129:209-23 pubmed publisher
    Interpretation of the biogeography of the genus Mahonia (Berberidaceae) is limited by the lack of fossil records in East Asia. Compressed fossil foliage, described here as Mahonia mioasiatica sp. nov...
  26. Donsky H, Clarke D. Reliéva, a Mahonia aquifolium extract for the treatment of adult patients with atopic dermatitis. Am J Ther. 2007;14:442-6 pubmed
    ..dermatitis treated for 12 weeks with Reliéva cream (a homeopathic product containing Psorberine, a proprietary Mahonia aquifolium extract)...
  27. Bernstein S, Donsky H, Gulliver W, Hamilton D, Nobel S, Norman R. Treatment of mild to moderate psoriasis with Reliéva, a Mahonia aquifolium extract--a double-blind, placebo-controlled study. Am J Ther. 2006;13:121-6 pubmed
    ..We investigated the efficacy and safety of an alternative treatment from natural sources, Mahonia aquifolium, for the management of mild to moderate psoriasis...
  28. Brezova V, Dvoranová D, Kost álová D. Oxygen activation by photoexcited protoberberinium alkaloids from Mahonia aquifolium. Phytother Res. 2004;18:640-6 pubmed
    Protoberberinium salts, i.e. berberine (I), palmatine (II) and jatrorrhizine (III) prepared from Mahonia aquifolium (Pursh) Nutt. belong to isoquinoline alkaloids possessing interesting biological activity (e.g...