vernonia

Summary

Summary: A plant genus of the family ASTERACEAE. Members contain germacrane and sesquiterpene LACTONES.

Top Publications

  1. Alawa C, Adamu A, Gefu J, Ajanusi O, Abdu P, Chiezey N, et al. In vitro screening of two Nigerian medicinal plants (Vernonia amygdalina and Annona senegalensis) for anthelmintic activity. Vet Parasitol. 2003;113:73-81 pubmed
    b>Vernonia amygdalina and Annona senegalensis, two plants used by local/smallholder livestock farmers in Nigeria as anthelmintic were screened for in vitro anthelmintic activity using Haemonchus contortus eggs. The extract of V...
  2. Kuo Y, Kuo Y, Yu A, Wu M, Ong C, Yang Kuo L, et al. Two novel sesquiterpene lactones, cytotoxic vernolide-A and -B, from Vernonia cinerea. Chem Pharm Bull (Tokyo). 2003;51:425-6 pubmed
    Bioassay-directed fractionation of an ethanolic extract of stems of Vernonia cinerea has resulted in the isolation of two novel sesquiterpene lactones, vernolide-A and -B...
  3. Babalola O, Anetor J, Adeniyi F. Amelioration of carbon tetrachloride-induced hepatotoxicity by terpenoid extract from leaves of Vernonia amydgalina. Afr J Med Med Sci. 2001;30:91-3 pubmed
    Sesquiterpene lactone extract from the leaves of Vernonia amygdalina was tested for antihepatotoxic activity. Adult male rats were selected for the study...
  4. Chen X, Zhan Z, Zhang X, Ding J, Yue J. Sesquiterpene lactones with potent cytotoxic activities from Vernonia chinensis. Planta Med. 2005;71:949-54 pubmed
    ..13-O-acetate (8), 8 alpha-tigloyloxyhirsutinolide 13-O-acetate ( 9) and vernolide-B (10) were isolated from Vernonia chinensis...
  5. Cai Y, Zhu Y, Liu D, Teng J, Wang J. [Pharmacognostical identification of Vernonia patula (Dry) Merr]. Zhong Yao Cai. 2006;29:116-8 pubmed
    To identify Vernonia patula (Dry) Merry. Characteristic study, microscopic identification and UV spectrometry method were carried out. Obvious characteristics were found in the tissue structures of the roots, stems and leaves...
  6. Leite S, Palhano G, Almeida S, Biavatti M. Wound healing activity and systemic effects of Vernonia scorpioides extract in guinea pig. Fitoterapia. 2002;73:496-500 pubmed
    The ethanolic leaves extract of Vernonia scorpioides was investigated for its wound healing activity in guinea pigs...
  7. Li R, Yu K, Wu Y, Tateno M, Hatanaka T, Hildebrand D. Vernonia DGATs can complement the disrupted oil and protein metabolism in epoxygenase-expressing soybean seeds. Metab Eng. 2012;14:29-38 pubmed publisher
    ..developed to co-express SlEPX and DGAT (diacylglycerol acyltransferase) genes (VgDGAT1 & 2) isolated from Vernonia galamensis, a high accumulator of epoxy fatty acids...
  8. Ogunbinu A, Flamini G, Cioni P, Ogunwande I, Okeniyi S. Essential oil constituents of Eclipta prostrata (L.) L. and Vernonia amygdalina Delile. Nat Prod Commun. 2009;4:421-4 pubmed
    ..L. and the aerial parts of Vernonia amygdalina Delile (Asteraceae) have been analyzed by capillary gas chromatography (GC) and gas chromatography/..
  9. Pillay P, Vleggaar R, Maharaj V, Smith P, Lategan C, Chouteau F, et al. Antiplasmodial hirsutinolides from Vernonia staehelinoides and their utilization towards a simplified pharmacophore. Phytochemistry. 2007;68:1200-5 pubmed
    The dichloromethane extract of the leaves of Vernonia staehelinoides Harv...

More Information

Publications86

  1. Grinberg S, Linder C, Kolot V, Waner T, Wiesman Z, Shaubi E, et al. Novel cationic amphiphilic derivatives from vernonia oil: synthesis and self-aggregation into bilayer vesicles, nanoparticles, and DNA complexants. Langmuir. 2005;21:7638-45 pubmed
    Self-assembling nanostructures were prepared from novel cationic amphiphilic compounds synthesized from vernonia oil, a natural epoxydized triglyceride...
  2. Mazumder U, Gupta M, Manikandan L, Bhattacharya S, Haldar P, Roy S. Evaluation of anti-inflammatory activity of Vernonia cinerea Less. extract in rats. Phytomedicine. 2003;10:185-8 pubmed
    The methanol extract of the whole plant of Vernonia cinerea Less. was evaluated for its anti-inflammatory activity in acute (carrageenin, histamine and serotonin induced rat paw edema) and a chronic model (cotton pouch induced granuloma)...
  3. Romanezi da Silveira R, Foglio M, Gontijo J. Effect of the crude extract of Vernonia polyanthes Less. on blood pressure and renal sodium excretion in unanesthetized rats. Phytomedicine. 2003;10:127-31 pubmed
    This study evaluated the effect of oral crude Vernonia polyanthes Less. hydroalcoholic extract administration (CHE, 0.5 and 1.0 g/kg body wt., daily for 7 days) on arterial blood pressure and renal sodium excretion in conscious rats...
  4. Li R, Yu K, Hatanaka T, Hildebrand D. Vernonia DGATs increase accumulation of epoxy fatty acids in oil. Plant Biotechnol J. 2010;8:184-95 pubmed publisher
    ..This fatty acid can accumulate to high levels in the seed oil of some plant species such as Vernonia galamensis and Stokesia laevis which are unsuitable for large-scale production...
  5. Pratheeshkumar P, Kuttan G. Vernolide-A, a sesquiterpene lactone from Vernonia cinerea, induces apoptosis in B16F-10 melanoma cells by modulating p53 and caspase-3 gene expressions and regulating NF-?B-mediated bcl-2 activation. Drug Chem Toxicol. 2011;34:261-70 pubmed publisher
    ..These results suggest that vernolide-A induces apoptosis via activation of p53-induced, caspase-3-mediated proapoptotic signaling and suppression of NF-?B-induced, bcl-2-mediated survival signaling...
  6. Adaramoye O, Ogungbenro B, Anyaegbu O, Fafunso M. Protective effects of extracts of Vernonia amygdalina, Hibiscus sabdariffa and vitamin C against radiation-induced liver damage in rats. J Radiat Res. 2008;49:123-31 pubmed
    The radioprotective efficacy of methanolic extracts of leaves of Vernonia amygdalina (VA) and Hibiscus sabdariffa (HS), and vitamin C (VIT C) against gamma radiation (4 Gy) induced liver damage was studied in male Wistar albino rats...
  7. Grinberg S, Kolot V, Linder C, Shaubi E, Kas yanov V, Deckelbaum R, et al. Synthesis of novel cationic bolaamphiphiles from vernonia oil and their aggregated structures. Chem Phys Lipids. 2008;153:85-97 pubmed publisher
    ..These bolaamphiphiles were derived from vernonia oil, whose main constituent is vernolic acid, a fatty acid with a unique combination of epoxy, carboxy and ..
  8. Pratheeshkumar P, Kuttan G. Ameliorative action of Vernonia cinerea L. on cyclophosphamide-induced immunosuppression and oxidative stress in mice. Inflammopharmacology. 2010;18:197-207 pubmed publisher
    ..The present study reports the protective role of Vernonia cinerea L. against the CTX-induced toxicity in Balb/c mice...
  9. Afolabi I, Osikoya I, Fajimi O, Usoro P, Ogunleye D, Bisi Adeniyi T, et al. Solenostemon monostachyus, Ipomoea involucrata and Carica papaya seed oil versus Glutathione, or Vernonia amygdalina: methanolic extracts of novel plants for the management of sickle cell anemia disease. BMC Complement Altern Med. 2012;12:262 pubmed publisher
    ..It is a disease prevalent throughout many populations. The use of medicinal plants and nutrition in managing SCD is gaining increasing attention...
  10. Nergard C, Matsumoto T, Inngjerdingen M, Inngjerdingen K, Hokputsa S, Harding S, et al. Structural and immunological studies of a pectin and a pectic arabinogalactan from Vernonia kotschyana Sch. Bip. ex Walp. (Asteraceae). Carbohydr Res. 2005;340:115-30 pubmed
    ..15 x 10(6)Da, respectively, were isolated from the dried powdered roots of Vernonia kotschyana Sch. Bip. ex Walp...
  11. Tian G, Zhang U, Zhang T, Yang F, Ito Y. Separation of flavonoids from the seeds of Vernonia anthelmintica Willd by high-speed counter-current chromatography. J Chromatogr A. 2004;1049:219-22 pubmed
    ..2',3,4,4'-tetrahydroxychalcone, 5,6,7,4'-tetrahydroxyflavone and butin, were separated from the seeds of Vernonia anthelmintica Willd by high-speed counter-current chromatography using a two-step operation...
  12. Nergard C, Diallo D, Michaelsen T, Malterud K, Kiyohara H, Matsumoto T, et al. Isolation, partial characterisation and immunomodulating activities of polysaccharides from Vernonia kotschyana Sch. Bip. ex Walp. J Ethnopharmacol. 2004;91:141-52 pubmed
    The roots from Vernonia kotschyana Sch. Bip. ex Walp. (Baccharoides adoensis var. kotschyana (Sch. Bip. ex Walp.) M.A. Isawumi, G.El-Ghazaly & B...
  13. Kumar P, Kuttan G. Vernonia cinerea L. scavenges free radicals and regulates nitric oxide and proinflammatory cytokines profile in carrageenan induced paw edema model. Immunopharmacol Immunotoxicol. 2009;31:94-102 pubmed publisher
    In this study, we evaluated the anti-oxidant and anti-inflammatory activities of the medicinal plant, Vernonia cinerea L (Asteraceae) using in vitro as well as in vivo models...
  14. Yedjou C, Izevbigie E, Tchounwou P. Preclinical assessment of vernonia amygdalina leaf extracts as DNA damaging anti-cancer agent in the management of breast cancer. Int J Environ Res Public Health. 2008;5:337-41 pubmed
    ..Hence, the aim of the present study was to assess the therapeutic efficacy of vernonia amygdalina (VA) leaf extracts as anti-cancer agent against human breast cancer in vitro using the MTT [3-(4, 5-..
  15. Latha L, Darah I, Jain K, Sasidharan S. Toxicity study of Vernonia cinerea. Pharm Biol. 2010;48:101-4 pubmed publisher
    The methanol extract of Vernonia cinerea Less (Asteraceae), which exhibited antimicrobial activity, was tested for toxicity...
  16. Malafronte N, Pesca M, Bisio A, Morales Escobar L, De Tommasi N. New flavonoid glycosides from Vernonia ferruginea. Nat Prod Commun. 2009;4:1639-42 pubmed
    ..ether 3-O-beta-D-xylopyranoside, along with other known flavonoids and phenolic derivatives, were isolated from the leaves of Vernonia ferruginea Less. Their structures were established on the basis of detailed spectral analysis.
  17. Barbastefano V, Cola M, Luiz Ferreira A, Farias Silva E, Hiruma Lima C, Rinaldo D, et al. Vernonia polyanthes as a new source of antiulcer drugs. Fitoterapia. 2007;78:545-51 pubmed
    Methanolic (VPME) and chloroformic (VPCL) extracts, obtained from the aerial parts of Vernonia polyanthes, were investigated for its antiulcerogenic properties...
  18. Ong K, Hsu A, Song L, Huang D, Tan B. Polyphenols-rich Vernonia amygdalina shows anti-diabetic effects in streptozotocin-induced diabetic rats. J Ethnopharmacol. 2011;133:598-607 pubmed publisher
    This study aims to investigate the hypoglycemic properties of Vernonia amygdalina Del. (VA) and its possible mechanisms of action in a single-dose STZ induced diabetic rat model.
  19. Owoeye O, Farombi E, Onwuka S. Gross morphometric reduction of rats' cerebellum by gamma irradiation was mitigated by pretreatment with Vernonia amygdalina leaf extract. Rom J Morphol Embryol. 2011;52:81-8 pubmed
    The methanolic extract of Vernonia amygdalina (M) or "bitter leaf" is known for its antioxidant activity, and antioxidants are noted to mitigate radiation damage in tissues...
  20. Chea A, Hout S, Long C, Marcourt L, Faure R, Azas N, et al. Antimalarial activity of sesquiterpene lactones from Vernonia cinerea. Chem Pharm Bull (Tokyo). 2006;54:1437-9 pubmed
    ..C and D as well as six known ones were isolated from the dichloromethane fraction of an aqueous extract from Vernonia cinerea. Their structures were elucidated by spectroscopic methods...
  21. Atangwho I, Ebong P, Eyong E, Asmawi M, Ahmad M. Synergistic antidiabetic activity of Vernonia amygdalina and Azadirachta indica: biochemical effects and possible mechanism. J Ethnopharmacol. 2012;141:878-87 pubmed publisher
    ..In Nigeria, the leaves of Vernonia amygdalina Del. (VA) and Azadirachta indica A...
  22. Zulfiqar A, Zhang J, Cui X, Qian Y, Zhou X, Xie Y. A new begomovirus associated with alpha- and betasatellite molecules isolated from Vernonia cinerea in China. Arch Virol. 2012;157:189-91 pubmed publisher
    A begomovirus disease complex associated with Vernonia cinerea showing yellow vein symptoms was studied. The full-length genomic DNA was comprised of 2739 nucleotides (nt) and contained the typical genome structure of begomoviruses...
  23. Iwalewa E, Iwalewa O, Adeboye J. Analgesic, antipyretic, anti-inflammatory effects of methanol, chloroform and ether extracts of Vernonia cinerea less leaf. J Ethnopharmacol. 2003;86:229-34 pubmed
    The chloroform, methanolic and ether extracts of Vernonia cinerea (Asteraceae; Less) leaf (100, 200 and 400mg/kg intraperitoneally) were tested in: acetic acid-induced writhing in mice, carrageenin-induced oedema and brewer's yeast-..
  24. Farombi E, Owoeye O. Antioxidative and chemopreventive properties of Vernonia amygdalina and Garcinia biflavonoid. Int J Environ Res Public Health. 2011;8:2533-55 pubmed publisher
    ..b>Vernonia amygdalina is a perennial herb belonging to the Asteraceae family...
  25. Toyang N, Verpoorte R. A review of the medicinal potentials of plants of the genus Vernonia (Asteraceae). J Ethnopharmacol. 2013;146:681-723 pubmed publisher
    The Vernonia genus has about one thousand species and members of the genus are widely used as food and medicine...
  26. Opata M, Izevbigie E. Aqueous Vernomia amygdalina extracts alter MCF-7 cell membrane permeability and efflux. Int J Environ Res Public Health. 2006;3:174-9 pubmed
    ..05). The amount of [3H]thymidine released into the medium was 1.7, 7.4, and 11.0 % for 0, 30, and 100 mug/ml VA respectively. Thus suggesting the membranes in VA-treated cells were compromised in a concentration-dependent fashion...
  27. Pratheeshkumar P, Kuttan G. Protective role of Vernonia cinerea L. against gamma radiation--induced immunosupression and oxidative stress in mice. Hum Exp Toxicol. 2011;30:1022-38 pubmed publisher
    The radioprotective effect of Vernonia cinerea extract was studied in balb/c mice...
  28. Wiesman Z, Dom N, Sharvit E, Grinberg S, Linder C, Heldman E, et al. Novel cationic vesicle platform derived from vernonia oil for efficient delivery of DNA through plant cuticle membranes. J Biotechnol. 2007;130:85-94 pubmed
    Novel cationic amphiphilic compounds were prepared from vernonia oil, a natural epoxidized triglyceride, and studied with respect to vesicle formation, encapsulation of biomaterials such as DNA, and their physical stability and transport ..
  29. Muraina I, Adaudi A, Mamman M, Kazeem H, Picard J, McGaw L, et al. Antimycoplasmal activity of some plant species from northern Nigeria compared to the currently used therapeutic agent. Pharm Biol. 2010;48:1103-7 pubmed publisher
    ..are obligate parasites of humans and animals. But due to the special requirements needed to culture Mycoplasma in the laboratory, little or no research has been done to evaluate the efficacy of medicinal plants on the organism...
  30. Asega A, do Nascimento J, Schroeven L, Van den Ende W, Carvalho M. Cloning, characterization and functional analysis of a 1-FEH cDNA from Vernonia herbacea (Vell.) Rusby. Plant Cell Physiol. 2008;49:1185-95 pubmed publisher
    Variations in the inulin contents have been detected in rhizophores of Vernonia herbacea during the phenological cycle...
  31. Nergard C, Kiyohara H, Reynolds J, Thomas Oates J, Matsumoto T, Yamada H, et al. Structures and structure-activity relationships of three mitogenic and complement fixing pectic arabinogalactans from the malian antiulcer plants Cochlospermum tinctorium A. Rich and Vernonia kotschyana Sch. Bip. ex Walp. Biomacromolecules. 2006;7:71-9 pubmed
    Structures of three pectic arabinogalactans, one from Vernonia kotschyana (Vk2a) and two from Cochlospermum tinctorium (Ct50A1 and Ct50A2), and their complement fixation and induction of B cell proliferation in vitro were compared...
  32. Ngatu N, Okajima M, Yokogawa M, Hirota R, Takaishi M, Eitoku M, et al. Anti-allergic effects of Vernonia amygdalina leaf extracts in hapten-induced atopic dermatitis-like disease in mice. Allergol Int. 2012;61:597-607 pubmed publisher
    ..In this study, AD-like disease was induced in NC/Nga mice so as to evaluate the anti-allergic effects of Vernonia amygdalina leaf extracts (VAM).
  33. Zhou J, Shang J, Ping F, Zhao G. Alcohol extract from Vernonia anthelmintica (L.) willd seed enhances melanin synthesis through activation of the p38 MAPK signaling pathway in B16F10 cells and primary melanocytes. J Ethnopharmacol. 2012;143:639-47 pubmed publisher
    b>Vernonia anthelmintica (L.) willd has been used in folk medicine to treat leukoderma in China for centuries. The promoting activities of its extract (AVE) in melanogenesis and possible signaling pathways were investigated in this article.
  34. Huo J, Yang S, Xie B, Liao S, Lin L, Ding J, et al. Cytotoxic sesquiterpenoids from Vernonia bockiana. J Asian Nat Prod Res. 2008;10:571-5 pubmed publisher
    ..A (5), hirsutolide (6), and beta-d-glucopyranosyl taraxinic ester (7), were isolated from the aerial part of Vernonia bockiana. Their structures were determined by spectroscopic analysis, especially 2D NMR...
  35. Adaramoye O, Akintayo O, Achem J, Fafunso M. Lipid-lowering effects of methanolic extract of Vernonia amygdalina leaves in rats fed on high cholesterol diet. Vasc Health Risk Manag. 2008;4:235-41 pubmed
    We investigated the lipid-lowering effects of methanolic extract of Vernonia amygdalina (VA) leaves in rats fed an high cholesterol diet, and compared with a standard hypolipidemic drug, Questran (Qu)...
  36. Iwalokun B. Enhanced antimalarial effects of chloroquine by aqueous Vernonia amygdalina leaf extract in mice infected with chloroquine resistant and sensitive Plasmodium berghei strains. Afr Health Sci. 2008;8:25-35 pubmed
  37. Sy G, Cisse A, Nongonierma R, Sarr M, Mbodj N, Faye B. Hypoglycaemic and antidiabetic activity of acetonic extract of Vernonia colorata leaves in normoglycaemic and alloxan-induced diabetic rats. J Ethnopharmacol. 2005;98:171-5 pubmed
    The aqueous extract of Vernonia colorata (Willd.) Drake (Composeae) leaves is used by African traditional medicine practitioners as a remedy for the treatment of diabetes...
  38. Abosi A, Raseroka B. In vivo antimalarial activity of Vernonia amygdalina. Br J Biomed Sci. 2003;60:89-91 pubmed
    Extracts from the leaves and root bark of Vernonia amygdalina are assessed for antimalarial activity against drug-sensitive Plasmodium berghei in mice...
  39. Risso W, Scarminio I, Moreira E. Antinociceptive and acute toxicity evaluation of Vernonia condensata Baker leaves extracted with different solvents and their mixtures. Indian J Exp Biol. 2010;48:811-6 pubmed
    Extract of Vernonia condensata (Asteraceae = Compositae) leaves has different uses in Brazilian folk medicine, which includes analgesic and antiinflamatory agent...
  40. Atangwho I, Egbung G, Ahmad M, Yam M, Asmawi M. Antioxidant versus anti-diabetic properties of leaves from Vernonia amygdalina Del. growing in Malaysia. Food Chem. 2013;141:3428-34 pubmed publisher
    The antioxidant and anti-diabetic properties of the sequential extracts of Vernonia amygdalina based on the chemical composition of the most effective anti-diabetic extract were studied...
  41. Fatima S, Rajasekhar M, Kumar K, Kumar M, Babu K, Rao C. Antidiabetic and antihyperlipidemic activity of ethyl acetate:isopropanol (1:1) fraction of Vernonia anthelmintica seeds in streptozotocin induced diabetic rats. Food Chem Toxicol. 2010;48:495-501 pubmed publisher
    Ethanolic extract prepared from the seeds of Vernonia anthelmintica was evaluated for its antihyperglycemic activity in STZ (Streptozotocin) induced diabetic rats. Administration of ethanolic extract at a dosage of 0...
  42. Njan A, Adzu B, Agaba A, Byarugaba D, Díaz Llera S, Bangsberg D. The analgesic and antiplasmodial activities and toxicology of Vernonia amygdalina. J Med Food. 2008;11:574-81 pubmed publisher
    b>Vernonia amygdalina possesses several bioactive compounds and is used in traditional medicines of southwestern Uganda, along with other regions. Its analgesic potential has not been investigated thus far...
  43. Yu K, McCracken C, Li R, Hildebrand D. Diacylglycerol acyltransferases from Vernonia and Stokesia prefer substrates with vernolic acid. Lipids. 2006;41:557-66 pubmed
    ..preferences of acyl CoA:diacylglycerol acyltransferases (DGAT) of two natural high accumulators of vernolic acid, Vernonia galamensis and Stokesia laevis, as compared with a common oilseed crop soybean...
  44. Pagno T, Blind L, Biavatti M, Kreuger M. Cytotoxic activity of the dichloromethane fraction from Vernonia scorpioides (Lam.) Pers. (Asteraceae) against Ehrlich's tumor cells in mice. Braz J Med Biol Res. 2006;39:1483-91 pubmed
    b>Vernonia scorpioides has been widely used in Brazil to treat skin problems and chronic wounds, such as ulcers of the lower limbs and diabetic lesions...
  45. Adesanoye O, Farombi E. Hepatoprotective effects of Vernonia amygdalina (astereaceae) in rats treated with carbon tetrachloride. Exp Toxicol Pathol. 2010;62:197-206 pubmed publisher
    The possible modulatory effect of methanolic extract of Vernonia amygdalina (MEVA), a plant widely consumed in the tropics and used locally in the treatment of fever, jaundice, stomach disorders and diabetes on the toxicity of CCl(4), was ..
  46. Erasto P, Grierson D, Afolayan A. Bioactive sesquiterpene lactones from the leaves of Vernonia amygdalina. J Ethnopharmacol. 2006;106:117-20 pubmed
    Phytochemical analysis of the leaves of Vernonia amygdalina yielded two known sesquiterpene lactones: vernolide and vernodalol. The two compounds were tested by agar dilution method against 10 bacteria strains and 5 fungi species...
  47. Iwalokun B, Efedede B, Alabi Sofunde J, Oduala T, Magbagbeola O, Akinwande A. Hepatoprotective and antioxidant activities of Vernonia amygdalina on acetaminophen-induced hepatic damage in mice. J Med Food. 2006;9:524-30 pubmed
    b>Vernonia amygdalina Del. (Family Compositae) is used in Nigerian folk medicine as a tonic and remedy against constipation, fever, high blood pressure, and many infectious diseases...
  48. Yu K, Li R, Hatanaka T, Hildebrand D. Cloning and functional analysis of two type 1 diacylglycerol acyltransferases from Vernonia galamensis. Phytochemistry. 2008;69:1119-27 pubmed publisher
    b>Vernonia galamensis accumulates vernolic acid (cis-12-epoxyoctadeca-cis-9-enoic acid) as the major fatty acid in its seed oil. Such epoxy fatty acids are useful in a number of industrial applications...
  49. Nippert J, Knapp A. Linking water uptake with rooting patterns in grassland species. Oecologia. 2007;153:261-72 pubmed
    ..Thus, our results suggest that variation in precipitation history and landscape positions are greater determinants of water-use patterns than would be expected based on absolute rooting depth...
  50. Klein J, Nowill A, Franchi G, Biavatti M, Quintão N, de Freitas R. Cytotoxic, antitumour and antimetastatic activity of two new polyacetylenes isolated from Vernonia scorpioides (Lam.) Pers. Basic Clin Pharmacol Toxicol. 2013;113:307-15 pubmed publisher
    b>Vernonia scorpioides (Lam.) Pers., popularly known as Enxuga, Erva-de-São Simão and Piracá, has been used in folk medicine for its anti-inflammatory, wound healing and antimicrobial properties...
  51. Maheshwari P, Songara B, Kumar S, Jain P, Srivastava K, Kumar A. Alkaloid production in Vernonia cinerea: Callus, cell suspension and root cultures. Biotechnol J. 2007;2:1026-32 pubmed
    Fast-growing callus, cell suspension and root cultures of Vernonia cinerea, a medicinal plant, were analyzed for the presence of alkaloids...
  52. Dutra F, Romero A, Quinteros C, Araújo R, García y Santos C. Poisoning of sheep by Vernonia plantaginoides (Less.) Hieron in Uruguay. J Vet Diagn Invest. 2016;28:392-8 pubmed publisher
    b>Vernonia plantaginoides (Less.) Hieron, previously known as Vernonia squarrosa, is a rhizomatous subshrub with purple flowers that is prevalent in the natural grassland of Uruguay, Argentina, and southern Brazil...
  53. Abay S, Lucantoni L, Dahiya N, Dori G, Dembo E, Esposito F, et al. Plasmodium transmission blocking activities of Vernonia amygdalina extracts and isolated compounds. Malar J. 2015;14:288 pubmed publisher
    ..The aim of this study was to assess the activity of Vernonia amygdalina leaf extracts and isolated compounds against gametocytes and sporogonic stages of Plasmodium berghei ..
  54. Ejike C, Awazie S, Nwangozi P, Godwin C. Synergistic postprandial blood glucose modulatory properties of Vernonia amygdalina (Del.), Gongronema latifolium (Benth.) and Occimum gratissimum (Linn.) aqueous decoctions. J Ethnopharmacol. 2013;149:111-6 pubmed publisher
    ..Three plants Vernonia amygdalina (Del.) (VA), Gongronema latifolium (Benth.) (GL) and Occimum gratissimum (Linn...
  55. Hua L, Li Y, Wang F, Lu D, Gao K. Biologically active steroids from the aerial parts of Vernonia anthelmintica Willd. Fitoterapia. 2012;83:1036-41 pubmed publisher
    A new steroid, vernoanthelsterone A (1), and five known steroids were isolated from the aerial parts of Vernonia anthelmintica Willd. Compound 1 possesses a ?(8(14))-15-one moiety...
  56. Bin Sayeed M, Mostofa A, Ferdous F, Islam M. A randomized, placebo-controlled, crossover study of an herbal preparation containing Vernonia cinerea in the treatment of type 2 diabetes. J Altern Complement Med. 2013;19:767-71 pubmed publisher
    ..double-blind, crossover clinical trial investigated the effects of an herbal preparation containing Vernonia cinerea in patients with type 2 diabetes mellitus...
  57. Pereira U, Boulais N, Lebonvallet N, Lefeuvre L, Gougerot A, Misery L. Development of an in vitro coculture of primary sensitive pig neurons and keratinocytes for the study of cutaneous neurogenic inflammation. Exp Dermatol. 2010;19:931-5 pubmed publisher
    ..Based on our screen, we found that extracts of Laminaria digitata and Vernonia sublutea inhibit CNI.
  58. Trevisan G, Rossato M, Walker C, Klafke J, Rosa F, Oliveira S, et al. Identification of the plant steroid ?-spinasterol as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive properties. J Pharmacol Exp Ther. 2012;343:258-69 pubmed publisher
    ..screens to identify novel, efficacious, and safe TRPV1 antagonists isolated from leaves of the medicinal plant Vernonia tweedieana Baker...
  59. Onyesom I, Okoh P. Quantitative analysis of nitrate and nitrite contents in vegetables commonly consumed in Delta State, Nigeria. Br J Nutr. 2006;96:902-5 pubmed
    ..The nitrate and nitrite contents in green vegetable (Amaranthus spp.), bitter leaf (Vernonia amygdalina), pumpkin (Telfaria occidentalis) and water leaf (Talinum triangulare) grown in different localities ..
  60. Oga E, Sekine S, Horie T. Ex vivo and in vivo investigations of the effects of extracts of Vernonia amygdalina, Carica papaya and Tapinanthus sessilifolius on digoxin transport and pharmacokinetics: assessing the significance on rat intestinal P-glycoprotein efflux. Drug Metab Pharmacokinet. 2013;28:314-20 pubmed
    b>Vernonia amygdalina (VA), Carica papaya (CP), and Tapinanthus sessilifolius (ML) are widely used in some countries as medicinal herbs to treat ailments including malaria, cancer, and diabetes...
  61. Boeing T, da Silva L, Somensi L, Cury B, Michels Costa A, Petreanu M, et al. Antiulcer mechanisms of Vernonia condensata Baker: A medicinal plant used in the treatment of gastritis and gastric ulcer. J Ethnopharmacol. 2016;184:196-207 pubmed publisher
    The leaves from Vernonia condensata Baker are broadly used in folk medicine for the treatment of gastric ulcers and dyspepsia...
  62. Egbung G, Atangwho I, Odey O, Ndiodimma V. The Lipid Lowering and Cardioprotective Effects of Vernonia calvoana Ethanol Extract in Acetaminophen-Treated Rats. Medicines (Basel). 2017;4: pubmed publisher
    ..The present study was designed to investigate the hypolipidemic and cardioprotective potentials of Vernonia calvoana (VC) ethanol extract in acetaminophen (paracetamol)-treated rats...
  63. Vongsombath C, de Boer H, Palsson K. Keeping leeches at bay: field evaluation of plant-derived extracts against terrestrial blood-sucking leeches (Haemadipsidae) in Lao PDR. Acta Trop. 2011;119:178-82 pubmed publisher
    ..Catunaregam spathulifolia Tirv. and Vernonia elaeagnifolia DC...
  64. Asega A, do Nascimento J, Carvalho M. Increased expression of fructan 1-exohydrolase in rhizophores of Vernonia herbacea during sprouting and exposure to low temperature. J Plant Physiol. 2011;168:558-65 pubmed publisher
    Rhizophores of Vernonia herbacea, an Asteraceae found in the Brazilian Cerrado, store high amounts of fructans that vary in composition over the phenological cycle...
  65. Iwalewa E, Adewunmi C, Omisore N, Adebanji O, Azike C, Adigun A, et al. Pro- and antioxidant effects and cytoprotective potentials of nine edible vegetables in southwest Nigeria. J Med Food. 2005;8:539-44 pubmed
    ..Crassocephalum rubens showed the highest antioxidant activity (56.5%), Solanum americanum and Vernonia amygdalina exhibited moderate antioxidant activity (26.0-37.5% and 14.8-36...
  66. Aliyu A, Musa A, Abdullahi M, Ibrahimi H, Oyewale A. Phytochemical screening and antibacterial activities of Vernonia ambigua, Vernonia blumeoides and Vernonia oocephala (Asteraceae). Acta Pol Pharm. 2011;68:67-73 pubmed
    Some Vernonia species (Vernonia ambigua, Vernonia blumeoides and Vernonia oocephala) used in Northern Nigerian traditional medicine, were subjected to phytochemical screening using standard procedures...
  67. Okwuzu J, Odeiga P, AdetoroOtubanjo O, Ezechi O. Cytotoxicity testing of aqueous extract of bitter leaf (Vernonia amygdalina Del) and sniper 1000EC (2,3 dichlorovinyl dimethyl phosphate) using the Alium cepa test. Afr Health Sci. 2017;17:147-153 pubmed publisher
    The unrefined nature of the herbal preparations from Vernonia amygdalina (VA) and toxicity potentials of Sniper may both have severe consequences on the biochemical and genetic systems.
  68. Zhu H, Tang Y, Pan L, Min Z. [Studies on bioactive constituents of whole herbs of Vernonia cinerea]. Zhongguo Zhong Yao Za Zhi. 2008;33:1986-8 pubmed
    To study the constituents of the whole herbs of Vernonia cinerea. by bio-activity guided isolation with PC-12 model. The constituents were separated by column chromatography and the structures were elucidated by spectroscopic methods...
  69. Williams R, Norris A, Slebodnick C, Merola J, Miller J, Andriantsiferana R, et al. Cytotoxic sesquiterpene lactones from Vernonia pachyclada from the Madagascar rainforest. J Nat Prod. 2005;68:1371-4 pubmed
    Bioassay-guided fractionation of the cytotoxic leaf extract of Vernonia pachyclada Baker led to the isolation of three new sesquiterpene lactones, designated glaucolides K-M (1-3)...
  70. Toyang N, Ateh E, Keiser J, Vargas M, Bach H, Tane P, et al. Toxicity, antimicrobial and anthelmintic activities of Vernonia guineensis Benth. (Asteraceae) crude extracts. J Ethnopharmacol. 2012;144:700-4 pubmed publisher
    This study examined the antibacterial, antifungal, and anthelmintic properties of extracts obtained from the plant Vernonia guineensis, a plant commonly used in traditional Cameroonian medicine.
  71. Kos O, Castro V, Murillo R, Poveda L, Merfort I. Ent-kaurane glycosides and sesquiterpene lactones of the hirsutinolide type from Vernonia triflosculosa. Phytochemistry. 2006;67:62-9 pubmed
    Investigation of the aerial parts of Vernonia triflosculosa afforded three hirsutinolides of which 8alpha-(4alpha-hydroxymethacryloyloxy)-10alpha-hydroxy-1,13-dimethoxy-hirsutinolide is new, three ent-kaurane diterpenes, among which the ..
  72. Austarheim I, Nergard C, Sanogo R, Diallo D, Paulsen B. Inulin-rich fractions from Vernonia kotschyana roots have anti-ulcer activity. J Ethnopharmacol. 2012;144:82-5 pubmed publisher
    Roots from Vernonia kotschyana are on the national list of essential drugs in Mali (West-Africa). It is sold under the name Gastrosedal and it used against ailments like gastritis and gastric ulcer...
  73. Kitonde C, Fidahusein D, Lukhoba C, Jumba M. Antimicrobial activity and phytochemical study of Vernonia glabra (Steetz) Oliv. & Hiern. in Kenya. Afr J Tradit Complement Altern Med. 2012;10:149-57 pubmed
    ..to investigate the antimicrobial activity and presence of active phytochemical compounds in different parts of Vernonia glabra; a plant used by herbalists in various regions of Kenya, for the treatment of gastrointestinal problems...
  74. Boonruang S, Prakobsri K, Pouyfung P, Srisook E, Prasopthum A, Rongnoparut P, et al. Inhibition of human cytochromes P450 2A6 and 2A13 by flavonoids, acetylenic thiophenes and sesquiterpene lactones from Pluchea indica and Vernonia cinerea. J Enzyme Inhib Med Chem. 2017;32:1136-1142 pubmed publisher
    ..study, activity-guided isolation identified four flavonoids 1-4 (apigenin, luteolin, chrysoeriol, quercetin) from Vernonia cinerea and Pluchea indica, four hirsutinolide-type sesquiterpene lactones 5-8 from V...
  75. Noumedem J, Mihasan M, Kuiate J, Stefan M, Cojocaru D, Dzoyem J, et al. In vitro antibacterial and antibiotic-potentiation activities of four edible plants against multidrug-resistant gram-negative species. BMC Complement Altern Med. 2013;13:190 pubmed publisher
  76. Saeed K, Eribo B, Ayorinde F, Collier L. Characterization of copolymer hydroxybutyrate/hydroxyvalerate from saponified vernonia, soybean, and "spent" frying oils. J AOAC Int. 2002;85:917-24 pubmed
    ..were biosynthesized by Ralstonia eutropha (formerly known as Alcaligenes eutrophus) by using saponified soybean, vernonia, and "spent" frying oils...
  77. Thomas E, Gopalakrishnan V, Somasagara R, Choudhary B, Raghavan S. Extract of Vernonia condensata, Inhibits Tumor Progression and Improves Survival of Tumor-allograft Bearing Mouse. Sci Rep. 2016;6:23255 pubmed publisher
    ..b>Vernonia genus is one of the common medicinal plants, which has wide spread usage in food and medicine...