petasites

Summary

Summary: A plant genus of the family ASTERACEAE. Members contain SESQUITERPENES. The common name of sweet coltsfoot is similar to the common name for TUSSILAGO.

Top Publications

  1. Gray R, Haggart K, Lee D, Cull S, Lipworth B. Effects of butterbur treatment in intermittent allergic rhinitis: a placebo-controlled evaluation. Ann Allergy Asthma Immunol. 2004;93:56-60 pubmed
    Butterbur (Petasites hybridus) contains the active ingredient petasin, which exhibits antileukotriene and antihistamine activity...
  2. Fiebich B, Grozdeva M, Hess S, Hull M, Danesch U, Bodensieck A, et al. Petasites hybridus extracts in vitro inhibit COX-2 and PGE2 release by direct interaction with the enzyme and by preventing p42/44 MAP kinase activation in rat primary microglial cells. Planta Med. 2005;71:12-9 pubmed
    Rhizomes of butterbur, Petasites hybridus L. (Asteraceae), have been used since ancient times for the treatment of inflammatory diseases...
  3. Lee D. Addressing the long-term safety aspects of butterbur therapy: a call for immediate action. Arch Otolaryngol Head Neck Surg. 2005;131:539-40; author reply 540 pubmed
  4. Watanabe T, Hata K, Hiwatashi K, Hori K, Suzuki N, Itoh H. Suppression of murine preadipocyte differentiation and reduction of visceral fat accumulation by a Petasites japonicus ethanol extract in mice fed a high-fat diet. Biosci Biotechnol Biochem. 2010;74:499-503 pubmed
    We investigated in this study the anti-obesity effect of an extract of Petasites japonicus (a culinary vegetable from Eastern Asia) on a murine adipocyte cell line (3T3-L1) and on diet-induced obesity-prone mice. An ethanol extract of P...
  5. Anderson N, Meier T, Borlak J. Toxicogenomics applied to cultures of human hepatocytes enabled an identification of novel petasites hybridus extracts for the treatment of migraine with improved hepatobiliary safety. Toxicol Sci. 2009;112:507-20 pubmed publisher
    Butterbur extracts (Petasites hybridus) are recommended for the prevention of migraine, but pharmacovigilance reports may be suggestive of rare hepatobiliary toxicity...
  6. Agosti R, Duke R, Chrubasik J, Chrubasik S. Effectiveness of Petasites hybridus preparations in the prophylaxis of migraine: a systematic review. Phytomedicine. 2006;13:743-6 pubmed
    The objective of this review was to evaluate the strength of evidence of effectiveness for Petasites hybridus in the prophylaxis of migraine...
  7. Brattström A, Schapowal A, Maillet I, Schnyder B, Ryffel B, Moser R. Petasites extract Ze 339 (PET) inhibits allergen-induced Th2 responses, airway inflammation and airway hyperreactivity in mice. Phytother Res. 2010;24:680-5 pubmed publisher
    The herbal Petasites hybridus (butterbur) extract (Ze 339, PET) is known to have leukotriene inhibiting properties, and therefore might inhibit allergic diseases...
  8. Wu S, Chen H, Lin Y. The mechanism of inhibitory actions of S-petasin, a sesquiterpene of Petasites formosanus, on L-type calcium current in NG108-15 neuronal cells. Planta Med. 2003;69:118-24 pubmed
    The effects of S-petasin, a sesquiterpene isolated from Petasites formosanus Kitamura, on ion currents in a mouse neuroblastoma and a rat glioma hybrid cell line, NG108-15, were examined with the aid of the whole-cell voltage-clamp ..
  9. Thomet O, Schapowal A, Heinisch I, Wiesmann U, Simon H. Anti-inflammatory activity of an extract of Petasites hybridus in allergic rhinitis. Int Immunopharmacol. 2002;2:997-1006 pubmed
    ..In vitro studies suggested that an extract of Petasites hybridus (Ze339) blocks LT synthesis in monocytes and granulocytes...

More Information

Publications86

  1. Lin L, Huang T, Wang S, Lin Y, Wu S, Ko W. Bronchodilatory effects of S-isopetasin, an antimuscarinic sesquiterpene of Petasites formosanus, on obstructive airway hyperresponsiveness. Eur J Pharmacol. 2008;584:398-404 pubmed publisher
    ..In conclusion, S-isopetasin may be beneficial as a bronchodilator in the treatment of chronic obstructive pulmonary disease and asthma exacerbations. ..
  2. Mizushina Y, Kamisuki S, Kasai N, Ishidoh T, Shimazaki N, Takemura M, et al. Petasiphenol: a DNA polymerase lambda inhibitor. Biochemistry. 2002;41:14463-71 pubmed
    Petasiphenol, a bio-antimutagen isolated from a Japanese vegetable, Petasites japonicus, selectively inhibits the activities of mammalian DNA polymerase lambda (pol lambda) in vitro...
  3. Arnold E, Benz T, Zapp C, Wink M. Inhibition of Cytosolic Phospholipase A2α (cPLA2α) by Medicinal Plants in Relation to Their Phenolic Content. Molecules. 2015;20:15033-48 pubmed publisher
    ..02 μg/mL), Sanguisorba officinalis (IC50 of 76.25 μg/mL), Orthosiphon stamineus (IC50 of 78.83 μg/mL), Petasites hybridus (IC50 of 81.02 μg/mL) and Tussilago farfara (IC50 of 123.28 μg/mL)...
  4. Wang G, Lin Y, Chen C, Wu X, Liao J, Ren J. Cellular calcium regulatory machinery of vasorelaxation elicited by petasin. Clin Exp Pharmacol Physiol. 2010;37:309-15 pubmed publisher
    ..Ca(2+) regulatory machinery involved in the vasorelaxation produced by petasin, a sesquiterpene isolated from Petasites formosanus. 2. Aortic rings isolated from Sprague-Dawley rats were exposed to petasin (0...
  5. Schenk A, Siewert B, Toff S, Drewe J. UPLC TOF MS for sensitive quantification of naturally occurring pyrrolizidine alkaloids in Petasites hybridus extract (Ze 339). J Chromatogr B Analyt Technol Biomed Life Sci. 2015;997:23-9 pubmed publisher
    ..PAs senkirkine, senecionine, seneciphylline, senecionine-N-oxide and seneciphylline-N-oxide in a CO2-extract of Petasites hybridus leaves (Ze 339) has been developed. The limit of quantification (LOQ) was 2ppb for all PAs...
  6. Jackson C, Lee D, Lipworth B. The effects of butterbur on the histamine and allergen cutaneous response. Ann Allergy Asthma Immunol. 2004;92:250-4 pubmed
    Butterbur or Petasites hybridus is an herbal remedy that exhibits antihistamine and antileukotriene activity and has been shown to attenuate the response to adenosine monophosphate challenge in patients with allergic rhinitis and asthma...
  7. Şeremet O, Barbuceanu F, Ionică F, Margină D, GuŢu C, Olaru O, et al. Oral toxicity study of certain plant extracts containing pyrrolizidine alkaloids. Rom J Morphol Embryol. 2016;57:1017-1023 pubmed
    ..Tussilago farfara (coltsfoot), Petasites hybridus (common butterbur), Senecio vernalis (eastern groundsel) and Symphytum officinale (comfrey) are ..
  8. Mohammadi M, Yousefi M, Habibi Z, Dastan D. Chemical composition and antioxidant activity of the essential oil of aerial parts of Petasites albus from Iran: a good natural source of euparin. Nat Prod Res. 2012;26:291-7 pubmed publisher
    The chemical composition of the essential oil of Petasites albus (known as 'Baba Adam' in Iran) was investigated by capillary gas chromatography and gas chromatography-mass spectrometry for the first time...
  9. Rostami Charati F, Hossaini Z, Khalilzadeh M. Novel isocyanide-based three-component synthesis of substituted 9Hfuro[ 2,3-f]chromene-8,9-dicarboxylates in water. Comb Chem High Throughput Screen. 2012;15:433-7 pubmed
    ..In these reactions, 1-(6-hydroxy-2-isopropenyl-1-benzofuranyl)- 1-ethanone was extracted from rhizomes of Petasites hybridus from northern Iran...
  10. Tepper S. Nutraceutical and Other Modalities for the Treatment of Headache. Continuum (Minneap Minn). 2015;21:1018-31 pubmed publisher
    ..While Level A evidence exists for the use of Petasites, caution should be exercised given the potential for hepatic toxicity...
  11. D Onofrio F, Raimo S, Spitaleri D, Casucci G, Bussone G. Usefulness of nutraceuticals in migraine prophylaxis. Neurol Sci. 2017;38:117-120 pubmed publisher
    ..randomized controlled trials of some of the most commonly used non-pharmacological treatments for the prophylaxis and treatment of migraine, including magnesium, coenzyme Q10, riboflavin (vitamin B2), petasites, and feverfew.
  12. Bodensieck A, Gaunitz F, Gebhardt R, Danesch U, Bauer R. Differential and stereoselective in vitro cytotoxicity of eremophilane sesquiterpenes of Petasites hybridus rhizomes in rat hepatocytes. Planta Med. 2011;77:32-9 pubmed publisher
    We tested two CO (2) extracts of Petasites hybridus L...
  13. Qian F, Guo G, Li Y, Kulka M. A novel eremophilane lactone inhibits FcεRI-dependent release of pro-inflammatory mediators: structure-dependent bioactivity. Inflamm Res. 2016;65:303-11 pubmed publisher
    ..Recently, eremophilane lactones, a novel family of sesquiterpene compound originally isolated from Petasites japonicas (Sieb. et Zucc...
  14. Huang C, Chang C, Tseng Y, Lee J, Sung P, Su J, et al. Bioactive Steroids from the Formosan Soft Coral Umbellulifera petasites. Mar Drugs. 2016;14: pubmed
    ..with eight known steroids (4-11), were isolated from a Formosan marine soft coral Umbellulifera petasites...
  15. Uchida S, Tagami K. Comparison of radiocesium concentration changes in leguminous and non-leguminous herbaceous plants observed after the Fukushima Dai-ichi Nuclear Power Plant accident. J Environ Radioact. 2018;186:3-8 pubmed publisher
    ..Among these species, Petasites japonicus (Siebold & Zucc.) Maxim. showed the highest 137Cs concentration in 2012-2016...
  16. Dong X, Li R, Gao X, Row K. Bakkenolides from Petasites tatewakianus. Fitoterapia. 2010;81:153-6 pubmed publisher
    A new bakkenolide and a known one were isolated from Petasites tatewakianus...
  17. Daniel O, Mauskop A. Nutraceuticals in Acute and Prophylactic Treatment of Migraine. Curr Treat Options Neurol. 2016;18:14 pubmed publisher
    ..The following review summarizes randomized controlled trials of some of the most commonly used non-pharmacological treatments, including magnesium, coenzyme Q10, riboflavin (vitamin B2), petasites, and feverfew (Table 1).
  18. Scheidel U, Bruelheide H. The impact of altitude and simulated herbivory on the growth and carbohydrate storage of Petasites albus. Plant Biol (Stuttg). 2004;6:740-5 pubmed
    ..by higher temperatures in the lowlands, compared to montane sites, prevent growth of the montane hemicryptophyte Petasites albus (Asteraceae)...
  19. Sheykhzade M, Smajilovic S, Issa A, Haunso S, Christensen S, Tfelt Hansen J. S-petasin and butterbur lactones dilate vessels through blockage of voltage gated calcium channels and block DNA synthesis. Eur J Pharmacol. 2008;593:79-86 pubmed publisher
    Eremophilanlactones isolated from roots of Petasites hybridus (L.) G.M. et Sch. (Asteraceae) and S-petasin have vasodilatory effects with pD(2) -log (EC(50)) values of 6.01+/-0.08, 5.24+/-0.10, 4.74+/-0.13, and 5.43+/-0...
  20. Zhang L, Hong Z, Zhang R, Sun X, Yuan Y, Hu J, et al. Bakkenolide A inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related signaling pathways. Biomed Pharmacother. 2016;83:958-966 pubmed publisher
    ..Bakkenolide A (Bak), extracted from Petasites tricholobus, has been suggested to against cancer and display protective effects on inflammatory cytokines ..
  21. Wang Y, Li R, Guo M, Zhang G, Zhang N, Ma Y. Bakkenolides from Petasites tricholobus and their neuroprotective effects related to antioxidant activities. Planta Med. 2009;75:230-5 pubmed publisher
    ..2), bakkenolide-IIIa ( 3) and bakkenolide-IVa ( 4) - were isolated from the extract of the rhizome of Petasites tricholobus...
  22. Laccourreye O, Werner A, Laccourreye L, Bonfils P. Benefits, pitfalls and risks of phytotherapy in clinical practice in otorhinolaryngology. Eur Ann Otorhinolaryngol Head Neck Dis. 2017;134:95-99 pubmed publisher
    ..Extracts of various herbs, notably echinacea, eucalyptus, petasites hybridus, pelargonium sidoides, rosemary, spirulina and thyme, show superiority over placebo for rhinosinusitis ..
  23. Park C, Kim M, Sok D, Kim J, Lee J, Kim M. Butterbur (Petasites japonicus Max.) extract improves lipid profiles and antioxidant activities in monosodium L-glutamate-challenged mice. J Med Food. 2010;13:1216-23 pubmed publisher
    We investigated the effect of the butanol fraction from the methanol extract of butterbur (Petasites japonicus Max.) (BMP) on the plasma lipid profiles and oxidative damage of liver in mice challenged with monosodium l-glutamate (MSG)...
  24. Kalin P. [The common butterbur (Petasites hybridus)--portrait of a medicinal herb]. Forsch Komplementarmed Klass Naturheilkd. 2003;10 Suppl 1:41-4 pubmed
    For hundreds of years butterbur (Petasites hybridus) has been used against many diseases...
  25. Sun Z, Gao G, Luo J, Zhang X, Zhang M, Feng J. A new neuroprotective bakkenolide from the rhizome of Peatasites tatewakianus. Fitoterapia. 2011;82:401-4 pubmed publisher
    ..The neuroprotective activity of the new compound was assayed with primary cultured neurons exposed to oxygen-glucose deprivation and oxidative insults. ..
  26. Aydın A, Zerbes V, Parlar H, Letzel T. The medical plant butterbur (Petasites): analytical and physiological (re)view. J Pharm Biomed Anal. 2013;75:220-9 pubmed publisher
    Butterbur (Petasites) is an ancient plant which has been used for medical and edible purposes with its spasmolytic agents. However, toxic alkaloid content of the plant limits its direct usage...
  27. Xie W, Zhang Q, Li P, Jia Z. Two triterpenoids and other constituents from Petasites tricholobus. Phytochemistry. 2005;66:2340-5 pubmed
    ..carbon framework, named petatrichol B (2), along with 10 known compounds were isolated from the rhizome of Petasites tricholobus...
  28. Choi J, Desta K, Saralamma V, Lee S, Lee S, Kim S, et al. LC-MS/MS characterization, anti-inflammatory effects and antioxidant activities of polyphenols from different tissues of Korean Petasites japonicus (Meowi). Biomed Chromatogr. 2017;31: pubmed publisher
    The Korean Petasites japonicus is a perennial plant used in folk medicine as a remedy for many diseases and popularly consumed as spring greens...
  29. Rapoport A, Bigal M. Preventive migraine therapy: what is new. Neurol Sci. 2004;25 Suppl 3:S177-85 pubmed
  30. Bodensieck A, Fabian W, Kunert O, Belaj F, Jahangir S, Schühly W, et al. Absolute configuration of eremophilane sesquiterpenes from Petasites hybridus: comparison of experimental and calculated circular dichroism spectra. Chirality. 2010;22:308-19 pubmed publisher
    ..1S,4aR,7R,8aR)-decahydro-1,8a-dimethyl-7-(1-methylethyl)napththalene) sesquiterpenes, 1-10, from Petasites hybridus were performed with molecular mechanics as well as density functional theory methods...
  31. Brattström A. A newly developed extract (Ze 339) from butterbur (Petasites hybridus L.) is clinically efficient in allergic rhinitis (hay fever). Phytomedicine. 2003;10 Suppl 4:50-2 pubmed
  32. Kim S, Kang S, Jeon J, Jung Y, Kim C, Pan C, et al. Rapid identification and evaluation of antioxidant compounds from extracts of Petasites japonicus by hyphenated-HPLC techniques. Biomed Chromatogr. 2012;26:199-207 pubmed publisher
    ..applied to the rapid structure determination of major compounds of methanol extracts from leaves and roots of Petasites japonicus...
  33. Wang G, Wu X, Lin Y, Ren J, Shum A, Wu Y, et al. Ca2+ channel blocking effect of iso-S-petasin in rat aortic smooth muscle cells. Eur J Pharmacol. 2002;445:239-45 pubmed
    ..examine the mechanisms underlying the putative hypotensive actions of iso-S-petasin, a sesquiterpene extract of Petasites formosanus through both in vivo and in vitro experiments...
  34. Brocksom T, Coelho F, Deprés J, Greene A, Freire De Lima M, Hamelin O, et al. First comprehensive bakkane approach: stereoselective and efficient dichloroketene-based total syntheses of (+/-)- and (-)-9-acetoxyfukinanolide, (+/-)- and (+)-bakkenolide A, (-)-bakkenolides III, B, C, H, L, V, and X, (+/-)- and (-)-homogynolide A,. J Am Chem Soc. 2002;124:15313-25 pubmed
  35. Matsuura H, Amano M, Kawabata J, Mizutani J. Isolation and measurement of quercetin glucosides in flower buds of Japanese butterbur (Petasites japonicus subsp. gigantea Kitam.). Biosci Biotechnol Biochem. 2002;66:1571-5 pubmed
    Three quercetin glucosides were isolated from flower buds of Japanese butterbur (Petasites japonicus subsp. gigantea Kitam...
  36. Danesch U. Petasites hybridus (Butterbur root) extract in the treatment of asthma--an open trial. Altern Med Rev. 2004;9:54-62 pubmed
    ..This study suggests the Petasites hybridus extract Petadolex is an effective and safe therapy for the treatment of asthma.
  37. Melzer J, Schrader E, Brattström A, Schellenberg R, Saller R. Fixed herbal drug combination with and without butterbur (Ze 185) for the treatment of patients with somatoform disorders: randomized, placebo-controlled pharmaco-clinical trial. Phytother Res. 2009;23:1303-8 pubmed publisher
    ..This herbal preparation (Ze185) showed to be an efficacious and safe short-term treatment in patients with somatoform disorders. ..
  38. Oelkers Ax R, Leins A, Parzer P, Hillecke T, Bolay H, Fischer J, et al. Butterbur root extract and music therapy in the prevention of childhood migraine: an explorative study. Eur J Pain. 2008;12:301-13 pubmed
    ..Butterbur root extract and music therapy might be superior to placebo and may represent promising treatment approaches in the prophylaxis of paediatric migraine. ..
  39. Oh S, Sok D, Kim M. Neuroprotective effects of butterbur and rough aster against kainic Acid-induced oxidative stress in mice. J Med Food. 2005;8:169-76 pubmed
    ..Based on these findings, the combination of butterbur extract and rough aster extract contains a functional agent or agents that protect against oxidative stress in the brain of mice. ..
  40. Yaoita Y. [New sesquiterpenoids from the rhizomes of Petasites japonicus MAXIM. and the roots of Ligularia dentata HARA]. Yakugaku Zasshi. 2012;132:887-93 pubmed
    ..Erigeron sumatrensis RETZ., Ligularia dentata HARA, Ligularia stenocephala MATSUM. et KOIDZ., Petasites japonicus MAXIM., and Tussilago farfara L., we isolated 83 new compounds...
  41. Danesch U, Rittinghausen R. Safety of a patented special butterbur root extract for migraine prevention. Headache. 2003;43:76-8 pubmed
    ..Safety data gained from clinical trials, postmarketing surveillance studies and pharmacovigilance are evaluated and discussed. The patented special butterbur root extract is safe for the treatment in humans. ..
  42. Lee K, Kang S, Park S, Choi Y, Lee Y, Im D. Anti-allergic and anti-inflammatory effects of bakkenolide B isolated from Petasites japonicus leaves. J Ethnopharmacol. 2013;148:890-4 pubmed publisher
    To elucidate the anti-allergic and anti-inflammatory effects of Petasites genus, we studied the effects of several compounds isolated from Petasites japonicas leaves. Bakkenolide B was isolated from Petasites japonicus leaves...
  43. Khaleghi F, Jantan I, Din L, Yaacob W, Khalilzadeh M, Bukhari S. Immunomodulatory effects of 1-(6-hydroxy-2-isopropenyl-1-benzofuran-5-yl)-1-ethanone from Petasites hybridus and its synthesized benzoxazepine derivatives. J Nat Med. 2014;68:351-7 pubmed publisher
    1-(6-Hydroxy-2-isopropenyl-1-benzofuran-5-yl)-1-ethanone (1), isolated from the roots of Petasites hybridus L., and a series of synthetic benzoxazepine derivatives of compound 1 (2-6) were evaluated for their immunomodulatory effects...
  44. Kang H, Jeong S, Cho J. Antimutagenic and anticarcinogenic effect of methanol extracts of Petasites japonicus Maxim leaves. J Vet Sci. 2010;11:51-8 pubmed
    The methanol extract from the leaves of Petasites japonicus Maxim (PJ) was studied for its (anti-)mutagenic effect with the SOS chromotest and reverse mutation assay...
  45. Diener H, Rahlfs V, Danesch U. The first placebo-controlled trial of a special butterbur root extract for the prevention of migraine: reanalysis of efficacy criteria. Eur Neurol. 2004;51:89-97 pubmed
    ..Butterbur was well tolerated. This small trial indicates that butterbur may be effective in the prophylaxis of migraine. ..
  46. Aydın A, Letzel T. Simultaneous investigation of sesquiterpenes, pyrrolizidine alkaloids and N-oxides in Butterbur (Petasites hybridus) with an offline 2D-combination of HPLC-UV and LC-MMI-ToF-MS. J Pharm Biomed Anal. 2013;85:74-82 pubmed publisher
    ..Among these natural products, butterbur (Petasites) has been used for years as herbal supplement for its anti-spasmodic and anti-inflammatory effects...
  47. Pothmann R, Danesch U. Migraine prevention in children and adolescents: results of an open study with a special butterbur root extract. Headache. 2005;45:196-203 pubmed
    ..Butterbur root extract shows a potential as an effective and well-tolerated migraine prophylaxis also for children and teenagers. ..
  48. Chizzola R, Langer T, Franz C. An approach to the inheritance of the sesquiterpene chemotypes within Petasites hybridus. Planta Med. 2006;72:1254-6 pubmed
    Sesquiterpene esters are the active principle in the medicinal plant Petasites hybridus. Two chemotypes, the petasin chemotype and the furanopetasin chemotype, are known, but only the first one is suitable for pharmaceutical purposes...
  49. Cui H, Kim M, Sok D. Protection by petaslignolide A, a major neuroprotective compound in the butanol extract of Petasites japonicus leaves, against oxidative damage in the brains of mice challenged with kainic acid. J Agric Food Chem. 2005;53:8526-32 pubmed
    The neuroprotective effect of petaslignolide A (PA), a furfuran lignan isolated from butanol fraction of Petasites japonicus (Sieb. et Zucc.) Maxim...
  50. Yu Q, Li D, Luo W, Guo Y. Function and evolution of sterile sex organs in cryptically dioecious Petasites tricholobus (Asteraceae). Ann Bot. 2011;108:65-71 pubmed publisher
    ..in some flowering plants, given their likely costs? To address this question, a cryptically dioecious species, Petasites tricholobus, in which male and female plants each have two floret types that appear pistillate and ..
  51. Lee D, Carstairs I, Haggart K, Jackson C, Currie G, Lipworth B. Butterbur, a herbal remedy, attenuates adenosine monophosphate induced nasal responsiveness in seasonal allergic rhinitis. Clin Exp Allergy. 2003;33:882-6 pubmed
    Butterbur (BB) or Petasites hybridus, a herbal remedy, exhibits in vitro inhibition of cysteinyl leukotriene biosynthesis...
  52. Zhang F, Wang Q, Wang Y, Guo M. Anti-allergic effects of total bakkenolides from Petasites tricholobus in ovalbumin-sensitized rats. Phytother Res. 2011;25:116-21 pubmed publisher
    The anti-allergic effect of total bakkenolides from the rhizome of Petasites tricholobus (BAPT) was evaluated in an ovalbumin-induced allergic rhinitis model in male Wistar rats...
  53. Lee D, Gray R, Robb F, Fujihara S, Lipworth B. A placebo-controlled evaluation of butterbur and fexofenadine on objective and subjective outcomes in perennial allergic rhinitis. Clin Exp Allergy. 2004;34:646-9 pubmed
    ..BB and FEX, in comparison to PL, were equally effective in attenuating the nasal response to AMP and in improving nasal symptoms, highlighting a potential role for BB in the treatment of allergic rhinitis. ..
  54. Schapowal A. Treating intermittent allergic rhinitis: a prospective, randomized, placebo and antihistamine-controlled study of Butterbur extract Ze 339. Phytother Res. 2005;19:530-7 pubmed
    ..Despite being a herbal drug, Butterbur Ze 339 has now been subject to a series of well controlled trials and should be considered as an alternative treatment for IAR. ..
  55. Diener H. [Migraine prevention with Petasites]. Med Monatsschr Pharm. 2006;29:40 pubmed
  56. Käufeler R, Polasek W, Brattström A, Koetter U. Efficacy and safety of butterbur herbal extract Ze 339 in seasonal allergic rhinitis: postmarketing surveillance study. Adv Ther. 2006;23:373-84 pubmed
    The efficacy and safety of the butterbur leaf extract Ze 339 (carbon dioxide extract from the leaves of Petasites hybridus L., 8 mg petasines per tablet) were tested in patients with seasonal allergic rhinitis...
  57. Esberg L, Wang G, Lin Y, Ren J. Iso-S-petasin, a hypotensive sesquiterpene from Petasites formosanus, depresses cardiac contraction and intracellular Ca2+ transients in adult rat ventricular myocytes. J Pharm Pharmacol. 2003;55:103-7 pubmed
    b>Petasites formosanus is an indigenous species of the medicinal plant Petasites which has been used to treat hypertension. Both S-petasin and its isoform iso-S-petasin have been shown to be the effective ingredients in P. formosanus...
  58. Han K, Sekikawa M, Shimada K, Lee C, Hashimoto N, Fukushima M. Japanese butterbur (Petasites japonicus) leaves increase hepatic oxidative stress in male rats. Biosci Biotechnol Biochem. 2012;76:2026-31 pubmed
    We investigated the adverse effects of Japanese butterbur leaves (Petasites japonicus, Compositae) in male F344/DuCrj rats. The rats were fed a control diet or a treatment diet containing 5% butterbur leaf powder for 4 weeks...
  59. Kim S, Min S, Shin H, Lee Y, Cho A, Kim S, et al. Evaluation of the antioxidant activities and nutritional properties of ten edible plant extracts and their application to fresh ground beef. Meat Sci. 2013;93:715-22 pubmed publisher
    ..05) better color stability than those without antioxidants. These results indicate that edible plant extracts are promising sources of natural antioxidants and can potentially be used as functional preservatives in meat products. ..
  60. Evans R, Taylor F. "Natural" or alternative medications for migraine prevention. Headache. 2006;46:1012-8 pubmed
  61. Leimgruber A. [Allergo-immunology]. Rev Med Suisse. 2006;2:89-92 pubmed
    ..This article presents two of these options, laser rhinophototherapy and Butterbur Ze 339, a drug derived from petasites. The immunodepressing effect of phototherapy has been tested in nasal mucosa...
  62. Lin C, Li C, Wu T. A novel phenylpropenoyl sulfonic acid and a new chlorophyll from the leaves of Petasites formosanus KITAMURA. Chem Pharm Bull (Tokyo). 2004;52:1151-2 pubmed
    ..sulfonic acid, petasiformin-A (1), and a new chlorophyll, petasiphyll-A (2), were isolated from the leaves of Petasites formosanus KITAMURA (Compositae)...
  63. Min B, Cui H, Lee H, Sok D, Kim M. A new furofuran lignan with antioxidant and antiseizure activities from the leaves of Petasites japonicus. Arch Pharm Res. 2005;28:1023-6 pubmed
    A new furofuran lignan (1) was isolated from the n-butanol fraction of the methanolic extract of the leaves of Petasites japonicus (Sieb. et Zucc.) Maxim. (Compositae)...
  64. Hasa Y, Tazaki H. Biosynthesis of fukinolic acid isolated from Petasites japonicus. Biosci Biotechnol Biochem. 2004;68:2212-4 pubmed
    The biosynthesis of fukinolic acid, which had been isolated from the Japanese fuki vegetable, Petasites japonicus, was investigated by feeding selected (13)C-labeled compounds to axenic cultures of P. japonicus...
  65. Choi Y, Lee K, Kim J, Kang S, Park S, Lee J, et al. Petatewalide B, a novel compound from Petasites japonicus with anti-allergic activity. J Ethnopharmacol. 2016;178:17-24 pubmed publisher
    The giant butterbur Petasites japonicus is used to treat asthma and allergic diseases in traditional Korean, Japanese, and Chinese medicine...
  66. Lee D, Haggart K, Robb F, Lipworth B. Butterbur, a herbal remedy, confers complementary anti-inflammatory activity in asthmatic patients receiving inhaled corticosteroids. Clin Exp Allergy. 2004;34:110-4 pubmed
    ..Further studies are now required to assess the potential role for BB as either monotherapy in milder patients or add-on therapy in more severe asthmatics. ..
  67. Gex Collet C, Imhof L, Brattström A, Pichler W, Helbling A. The butterbur extract petasin has no effect on skin test reactivity induced by different stimuli: a randomized, double-blind crossover study using histamine, codeine, methacholine, and aeroallergen solutions. J Investig Allergol Clin Immunol. 2006;16:156-61 pubmed
    ..The mechanism by which Ze 339 is effective in the treatment of seasonal allergic rhinitis still needs to be elucidated. ..
  68. Rios J, Passe M. Evidenced-based use of botanicals, minerals, and vitamins in the prophylactic treatment of migraines. J Am Acad Nurse Pract. 2004;16:251-6 pubmed
  69. Horak S, Koschak A, Stuppner H, Striessnig J. Use-dependent block of voltage-gated Cav2.1 Ca2+ channels by petasins and eudesmol isomers. J Pharmacol Exp Ther. 2009;330:220-6 pubmed publisher
    ..Because clinical evidence exists for migraine-prophylactic actions of Petasites hybridus extracts, we investigated whether petasins comprising the main constituents of the extract inhibit ..
  70. Sok D, Oh S, Kim Y, Kang H, Kim M. Neuroprotection by extract of Petasites japonicus leaves, a traditional vegetable, against oxidative stress in brain of mice challenged with kainic acid. Eur J Nutr. 2006;45:61-9 pubmed
    ..b>Petasites japonicus MAX (butterbur), cultivated as culinary vegetables in Eastern Asia, contains various kinds of phenolic ..
  71. Giles M, Ulbricht C, Khalsa K, Kirkwood C, Park C, Basch E. Butterbur: an evidence-based systematic review by the natural standard research collaboration. J Herb Pharmacother. 2005;5:119-43 pubmed
    ..An evidence-based systematic review including written and statistical analysis of scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing. ..
  72. Wang S, Jin D, Xie C, Wang H, Wang M, Xu J, et al. Isolation, characterization, and neuroprotective activities of sesquiterpenes from Petasites japonicus. Food Chem. 2013;141:2075-82 pubmed publisher
    ..b>Petasites japonicus, a wild vegetable, belongs to the family Compositae and its extract has shown the neuroprotective ..
  73. Lee H, Kim S, Abd El Aty A, Chung H, Kabir M, Rahman M, et al. Liquid chromatography-tandem mass spectrometry quantification of acetamiprid and thiacloprid residues in butterbur grown under regulated conditions. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1055-1056:172-177 pubmed publisher
    ..The highest and lowest residues were obtained for the 7 and 0 days' treatment and the 21 and 14 days' treatment, respectively. The developed method is simple and accurate and can be extrapolated to other leafy vegetables. ..
  74. Lee J, Yang E, Yun C, Kim D, Kim I. Suppressive effect of Petasites japonicus extract on ovalbumin-induced airway inflammation in an asthmatic mouse model. J Ethnopharmacol. 2011;133:551-7 pubmed publisher
    Asthma is a disease marked by airway inflammation. Petasites japonicus (Pj) is known as an herb for treating asthma, oxidant stress and gastric ulcer in traditional Oriental medicine...
  75. Shimoda H, Tanaka J, Yamada E, Morikawa T, Kasajima N, Yoshikawa M. Anti type I allergic property of Japanese butterbur extract and its mast cell degranulation inhibitory ingredients. J Agric Food Chem. 2006;54:2915-20 pubmed
    ..1 microg/mL). Consequently, On the basis of its inhibition of mast cell activation and direct smooth muscle reaction induced by released mediators, JBE was found to suppress the type I allergic reaction. ..
  76. Sadler C, Vanderjagt L, Vohra S. Complementary, holistic, and integrative medicine: butterbur. Pediatr Rev. 2007;28:235-8 pubmed
  77. Wang G, Liao J, Hintz K, Chen W, Su M, Lin Y, et al. Calcium-antagonizing activity of S-petasin, a hypotensive sesquiterpene from Petasites formosanus, on inotropic and chronotropic responses in isolated rat atria and cardiac myocytes. Naunyn Schmiedebergs Arch Pharmacol. 2004;369:322-9 pubmed
    b>Petasites formosanus, an indigenous species of Petasites, has been used to treat cardiovascular diseases such as hypertension for years. We have suggested recently that S-petasin, a major sesquiterpene from P...