Summary: A plant genus in the family ARALIACEAE, order Apiales, subclass Rosidae. It is the source of cirensenosides (triterpenoid saponins).

Top Publications

  1. Li X, Sun S, Du G, Qi L, Williams S, Wang C, et al. Effects of Oplopanax horridus on human colorectal cancer cells. Anticancer Res. 2010;30:295-302 pubmed
    In this study, we investigated the inhibitive effects of Oplopanax horridus extract (OhE) and its fractions (OhF1, OhF2, OhF3, OhF4 and OhF5) on the growth of human colorectal cancer cells and the possible mechanisms involved were ..
  2. Sun S, Du G, Qi L, Williams S, Wang C, Yuan C. Hydrophobic constituents and their potential anticancer activities from Devil's Club (Oplopanax horridus Miq.). J Ethnopharmacol. 2010;132:280-5 pubmed publisher
    Devil's Club (Oplopanax horridus) is one of the most important spiritual and medicinal plants to many indigenous peoples of Alaska and the Pacific Northwest...
  3. Huang W, Zhang Q, Wang C, Yuan C, Li S. Isolation and identification of two new polyynes from a North American ethnic medicinal plant--Oplopanax horridus (Smith) Miq. Molecules. 2010;15:1089-96 pubmed publisher
    Two new polyynes, named oplopantriol A (5) and oplopantriol B (6), were isolated from the root bark of Oplopanax horridus (Smith) Miq, an ethnic medicinal plant of North America, along with four known polyynes: (3S,8S)-falcarindiol (1), ..
  4. Inui T, Wang Y, Nikolic D, Smith D, Franzblau S, Pauli G. Sesquiterpenes from Oplopanax horridus. J Nat Prod. 2010;73:563-7 pubmed publisher
    From the anti-TB active fractions of the inner stem bark of Oplopanax horridus, two new heterocyclic nerolidol derivatives, 3,10-epoxy-3,7,11-trimethyldodeca-1,6-dien-11-ol, named neroplomacrol (1), and rel-(3S,6R,7S,10R)-7,10-epoxy-3,7,..
  5. Mader T, Werner R, Chamberlain D. Corneal perforation and delayed anterior chamber collapse from a devil's club thorn. Cornea. 2008;27:961-2 pubmed publisher
    ..Our experience suggests that devil's club corneal injuries should be examined daily after the initial injury. The anterior chamber may suddenly collapse after a deeply embedded thorn becomes dislodged. ..
  6. Johnson L. Gitksan medicinal plants--cultural choice and efficacy. J Ethnobiol Ethnomed. 2006;2:29 pubmed
    ..I examine use of medicinal plants from a "biobehavioral" perspective to illuminate cultural selection of plants used for medicine by the Gitksan of northwestern British Columbia, Canada...
  7. Huang W, Yang J, Zhao J, Wang C, Yuan C, Li S. Quantitative analysis of six polyynes and one polyene in Oplopanax horridus and Oplopanax elatus by pressurized liquid extraction and on-line SPE-HPLC. J Pharm Biomed Anal. 2010;53:906-10 pubmed publisher
    ..oplopandiol acetate, oplopantriol A, oplopantriol B, and one polyene, (S,E)-nerolidol, in Oplopanax horridus and Oplpanax elatus...
  8. Sun S, Li X, Wang C, Williams S, Yuan C. Improving anticancer activities of Oplopanax horridus root bark extract by removing water-soluble components. Phytother Res. 2010;24:1166-74 pubmed publisher
    ..Data from this study suggested that the 70% and 100% ethanol fractions are active antiproliferative fractions and that induction of apoptosis is the mechanism involved in the antiproliferative effect observed. ..
  9. Qiu F, Cai G, Jaki B, Lankin D, Franzblau S, Pauli G. Quantitative purity-activity relationships of natural products: the case of anti-tuberculosis active triterpenes from Oplopanax horridus. J Nat Prod. 2013;76:413-9 pubmed publisher
    ..The anti-tuberculosis active triterpenes from the Alaskan ethnobotanical Oplopanax horridus were selected as a case for the development of the quantitative PAR (QPAR) concept...

More Information


  1. Wang C, Zhang Z, Huang W, Du G, Wen X, Calway T, et al. Identification of potential anticancer compounds from Oplopanax horridus. Phytomedicine. 2013;20:999-1006 pubmed publisher
    b>Oplopanax horridus is a plant native to North America. Previous reports have demonstrated that this herb has antiproliferative effects on cancer cells but study mostly focused on its extract or fractions...
  2. Sun W, He Y, Xu L, Zhang B, Qi L, Yang J, et al. Pharmacokinetic profiles of falcarindiol and oplopandiol in rats after oral administration of polyynes extract of Oplopanax elatus. Chin J Nat Med. 2016;14:714-720 pubmed publisher
    Polyynes, such as facarindiol (FAD) and oplopandiol (OPD), are responsible for anticancer activities of Oplopanax elatus (O. elatus)...
  3. Inui T, Wang Y, Deng S, Smith D, Franzblau S, Pauli G. Counter-current chromatography based analysis of synergy in an anti-tuberculosis ethnobotanical. J Chromatogr A. 2007;1151:211-5 pubmed
    The crude extract of an Alaskan ethnobotanical plant, Oplopanax horridus, was subjected to counter-current chromatography (CCC), and the selected active regions were evaluated for their synergistic effects with an in vitro model of anti-..
  4. Wang C, Aung H, Mehendale S, Shoyama Y, Yuan C. High performance liquid chromatographic analysis and anticancer potential of Oplopanax horridus: comparison of stem and berry extracts. Fitoterapia. 2010;81:132-9 pubmed publisher
    b>Oplopanax horridus or devil's club is a herbal medicine distributed in North America. The constituents and pharmacological activities of O. horridus (OPH) are largely unknown...
  5. Inui T, Wang Y, Pro S, Franzblau S, Pauli G. Unbiased evaluation of bioactive secondary metabolites in complex matrices. Fitoterapia. 2012;83:1218-25 pubmed publisher
    ..The proof of principle is demonstrated for the anti-tuberculosis (TB) activity of the Alaskan ethnobotanical, Oplopanax horridus...
  6. Liu P, Li M, Kang T, Dou D, Smith D. New lupane-type triterpenoid saponins from leaves of Oplopanax horridus (Devil's Club). Nat Prod Commun. 2010;5:1019-22 pubmed
    Two new lupane type saponins, along with one known saponin were isolated from leaves of Oplopanax horridus (Devil's Club)...
  7. Huang W, Zhang Q, Meng L, Yuan C, Wang C, Li S. Oplopanphesides A-C, three new phenolic glycosides from the root barks of Oplopanax horridus. Chem Pharm Bull (Tokyo). 2011;59:676-9 pubmed
    Three new phenolic glycosides, named oplopanphesides A-C (1-3), have been isolated from the root barks of Oplopanax horridus...
  8. Calway T, Du G, Wang C, Huang W, Zhao J, Li S, et al. Chemical and pharmacological studies of Oplopanax horridus, a North American botanical. J Nat Med. 2012;66:249-56 pubmed publisher
    b>Oplopanax horridus (OH), or Devil's club, is an ethnobotanical used by the indigenous people native to the Pacific Northwest of North America...
  9. Bu Q, Zhang W, Chen Q, Zhang C, Gong X, Liu W, et al. Anti-diabetic effect of ginsenoside Rb(3) in alloxan-induced diabetic mice. Med Chem. 2012;8:934-41 pubmed
    ..Therefore, it was suggested that ginsenoside possesses the potential of the clinical use in preventing and treating diabetes. ..
  10. Wang G, Yang X, Xu J. Structures of four new triterpenoid saponins from the leaves of Oplopanax elatus Nakai. Yao Xue Xue Bao. 2004;39:354-8 pubmed
    Isolation and structural elucidation of the triterpenoid saponins of Oplopanax elatus Nakai...
  11. Qiao X, Sun W, Wang C, Zhang L, Li P, Wen X, et al. Polyyne-Enriched Extract from Oplopanax elatus Significantly Ameliorates the Progression of Colon Carcinogenesis in ApcMin/+ Mice. Molecules. 2017;22: pubmed publisher
    Colorectal cancer (CRC) is the third most common cancer in the world. Oplopanax elatus is widely used in traditional medicine. However, little is known about its pharmacological effects and bioactive compounds...
  12. Dou D, Hu X, Zhao Y, Kang T, Liu F, Kuang H, et al. Studies on the anti-psoriasis constituents of Oplopanax elatus Nakai. Nat Prod Res. 2009;23:334-42 pubmed publisher
    Seven compounds were isolated from roots and stems of Oplopanax elatus, of which compounds 3, 4, 5 and 6 were isolated for the first time from the title plant; compounds 1 and 2 are new compounds and characterised to be 3,3'-dimethoxy-4,..
  13. Yang M, Kwon H, Kim Y, Lee K, Yang H. Oploxynes A and B, polyacetylenes from the stems of Oplopanax elatus. J Nat Prod. 2010;73:801-5 pubmed publisher
    ..oploxynes A (1) and B (2), and the known oplopandiol (3) and falcarindiol (4) were isolated from the stem of Oplopanax elatus...
  14. Tai J, Cheung S, Chan E, Hasman D. Inhibition of human ovarian cancer cell lines by devil's club Oplopanax horridus. J Ethnopharmacol. 2010;127:478-85 pubmed publisher
    ..It is one of the few North American medicinal herbs that have been tested for anti-ovarian cancer activities. ..
  15. Shao L, Nie M, Chen M, Wang J, Wang C, Huang W, et al. Screening and identifying antioxidants from Oplopanax elatus using 2,2'-diphenyl-1-picrylhydrazyl with off-line two-dimensional HPLC coupled with diode array detection and tandem time-of-flight mass spectrometry. J Sep Sci. 2016;39:4269-4280 pubmed publisher
    The root of Oplopanax elatus (Nakai) Nakai has a well-known history of use for the treatment of diseases such as neurasthenia, cardiovascular disorders, and cancer by the native people in northeast China...
  16. Tai J, Cheung S, Cheah S, Chan E, Hasman D. In vitro anti-proliferative and antioxidant studies on Devil's Club Oplopanax horridus. J Ethnopharmacol. 2006;108:228-35 pubmed
    Devil's Club, Oplopanax horridus (OH), is a widely used folk medicine in Alaska and British Columbia for treating a variety of ailments including arthritis, fever and diabetes...
  17. Cheung S, Tai J, Hasman D, Ou D, Warnock G. Inhibition of Human Pancreatic Cancer Cell Proliferation by Devil's Club Oplopanax horridus and Its Polyacetylene Bioactive Compound. Nutr Cancer. 2015;67:954-64 pubmed publisher
    Devil's club Oplopanax horridus (DC) is a close relative of ginseng; its inner root and stem bark extract showed antiproliferation activity on human leukemia, ovarian, breast and colon cancer cells...
  18. Reunov A, Reunova G, Alexandrova Y, Muzarok T, Zhuravlev Y. The pollen metamorphosis phenomenon in Panax ginseng, Aralia elata and Oplopanax elatus; an addition to discussion concerning the Panax affinity in Araliaceae. Zygote. 2009;17:1-17 pubmed publisher
    ..ginseng, Aralia elata and Oplopanax elatus collected during their pollination periods...