cnidium

Summary

Summary: A plant genus of the family APIACEAE. Members contain osthol.

Top Publications

  1. Park H, Jo S, Jung U, Yee S. Restoration of the immune functions in aged mice by supplementation with a new herbal composition, HemoHIM. Phytother Res. 2008;22:36-42 pubmed
    ..the ethanol-insoluble fraction to the total water extract of a mixture of three edible herbs, Angelica Radix, Cnidium Rhizoma and Paeonia Radix...
  2. Shin E, Lee C, Sung S, Kim Y, Hwang B, Lee M. Antifibrotic activity of coumarins from Cnidium monnieri fruits in HSC-T6 hepatic stellate cells. J Nat Med. 2011;65:370-4 pubmed publisher
    The CHCl(3) fraction of Cnidium monnieri fruits significantly inhibited the proliferation of hepatic stellate cells in an in-vitro assay system employing HSC-T6 hepatic stellate cell lines...
  3. Zhao J, Zhou M, Liu Y, Zhang G, Luo Y. Chromones and coumarins from the dried fructus of Cnidium monnieri. Fitoterapia. 2011;82:767-71 pubmed publisher
    Chemical investigations on the ethanolic extract of the dried fructus of Cnidium monnieri offered three chromones and eight coumarins...
  4. Kim S, Ahn J, Han S, Hwang B, Kim S, Lee M. Anti-adipogenic chromone glycosides from Cnidium monnieri fruits in 3T3-L1 cells. Bioorg Med Chem Lett. 2012;22:6267-71 pubmed publisher
    ..chromone glycosides, monnierisides A (3), B (10), C (11), D (12), E (13), F (15) and G (16) were isolated from Cnidium. monnieri, together with ten known chromone derivatives, undulatoside A (1), cnidimol C (2), saikochromoside A (4)..
  5. Jeong J, Ju S, Park J, Lee J, Yun K, Kwon S, et al. Antioxidant activity in essential oils of Cnidium officinale makino and Ligusticum chuanxiong Hort and their inhibitory effects on DNA damage and apoptosis induced by ultraviolet B in mammalian cell. Cancer Epidemiol. 2009;33:41-6 pubmed publisher
    Owing to their high volatile aroma, the dried rhizomes of Cnidium officinale (C. officinale) and Ligusticum chuanxiong (L...
  6. Wang S, Lin T, Lu C, Huang W. Osthole and imperatorin, the active constituents of Cnidium monnieri (L.) Cusson, facilitate glutamate release from rat hippocampal nerve terminals. Neurochem Int. 2008;53:416-23 pubmed publisher
    We examined the effects of osthole and imperatorin, two active compounds of Cnidium monnieri (L.) Cusson, on the release of glutamate from rat hippocampal synaptosomes and investigated the possible mechanism...
  7. Matsuda H, Tomohiro N, Ido Y, Kubo M. Anti-allergic effects of cnidii monnieri fructus (dried fruits of Cnidium monnieri) and its major component, osthol. Biol Pharm Bull. 2002;25:809-12 pubmed
    ..types I and IV) of the 70% ethanol extract (CM-ext) obtained from Cnidii Monnieri Fructus (dried fruits of Cnidium monnieri) were investigated on 48 h homologous passive cutaneous anaphylaxis (PCA), 2, 4-dinitrofluorobenzene (..
  8. Wang Z, Kim J, Wang M, Shu S, Ahn Y. Larvicidal activity of Cnidium monnieri fruit coumarins and structurally related compounds against insecticide-susceptible and insecticide-resistant Culex pipiens pallens and Aedes aegypti. Pest Manag Sci. 2012;68:1041-7 pubmed publisher
    An assessment was made of the toxicity of imperatorin and osthole identified in Cnidium monnieri fruit, 11 related compounds and five insecticides to larvae from insecticide-susceptible Culex pipiens pallens (KS-CP strain) and Aedes ..
  9. Morino C, Morita Y, Minami K, Nishidono Y, Nakashima Y, Ozawa R, et al. Oviposition inhibitor in umbelliferous medicinal plants for the common yellow swallowtail (Papilio machaon). J Nat Med. 2018;72:161-165 pubmed publisher
    ..Schmidt ex Miquel were the most numerous, those on Saposhnikovia divaricata Schischkin and Cnidium officinale Makino were rare, and Bupleurum falcatum Linné was not oviposited at all...

More Information

Publications62

  1. Kwon J, Ahn Y. Acaricidal activity of Cnidium officinale rhizome-derived butylidenephthalide against Tyrophagus putrescentiae (Acari: Acaridae). Pest Manag Sci. 2003;59:119-23 pubmed
    The acaricidal activity of materials derived from the rhizome of Cnidium officinale Makino against Tyrophagus putrescentiae Schrank adults was examined using direct contact application and fumigation methods, and compared with that of ..
  2. Lv X, Wang C, Hou J, Zhang B, Deng S, Tian Y, et al. Isolation and identification of metabolites of osthole in rats. Xenobiotica. 2012;42:1120-7 pubmed publisher
    Osthole (Ost), one of the major components of Cnidium monnieri (L.) Cusson, is had the structure of an isopentenoxy-coumarin with a range of pharmacological activities...
  3. Hsieh M, Hsieh C, Wang W, Chen C, Lin C, Wu C. Osthole improves aspects of spatial performance in ovariectomized rats. Am J Chin Med. 2004;32:11-20 pubmed
    ..The action mechanism of the effects of osthole on performance deficits was related to the estrogen-like properties and activating the central cholinergic neuronal system. ..
  4. Zhou J, Sun X, Wang S. Micelle-mediated extraction and cloud-point preconcentration of osthole and imperatorin from Cnidium monnieri with analysis by high performance liquid chromatography. J Chromatogr A. 2008;1200:93-9 pubmed publisher
    ..was developed for the separation and determination of hydrophobic compounds osthole and imperatorin from Cnidium monnieri by high performance liquid chromatography with photodiode array detection...
  5. Zhou Y, Li L, Feng F, Yuan H, Gao D, Fu L, et al. Osthole attenuates spinal cord ischemia-reperfusion injury through mitochondrial biogenesis-independent inhibition of mitochondrial dysfunction in rats. J Surg Res. 2013;185:805-14 pubmed publisher
    Osthole, the main bioactive compounds isolated from the traditional Chinese medical herb broad Cnidium monnieri (L.) cusson, has been shown to exert spectrum of pharmacologic activities...
  6. Weng D, Li T. [Simultaneous determination of 5 active components in Fructus Cnidii by HPLC]. Zhongguo Zhong Yao Za Zhi. 2007;32:1883-5 pubmed
    ..999 7) for imperatorin, 100-2 000 microg x mL(-1) (r = 0.999 9) for osthole. The average recoveries were all above 95%. The method is simple, sensitive and accurate with good reproducibility. ..
  7. Feng D, Ke C, Lu C, Li S. Herbal plants as a promising source of natural antifoulants: evidence from barnacle settlement inhibition. Biofouling. 2009;25:181-90 pubmed publisher
    ..acetate, ethanol and aqueous extracts from six common Chinese herbs (Carpesium abrotanoides, Melia toosendan, Cnidium monnieri, Vitex negundo, Stemona sp...
  8. Meng F, Xiong Z, Sun Y, Li F. Coumarins from Cnidium monnieri (L.) and their proliferation stimulating activity on osteoblast-like UMR106 cells. Pharmazie. 2004;59:643-5 pubmed
    The proliferation of various fractions of alcoholic extracts from fruits of Cnidium monnieri (L.) Cuss (umbelifera) were screened using the osteoblast-like UMR106 cells in vitro...
  9. An F, Wang S, Zhang D, Zhang L, Mu J. [Pharmacokinetics of osthole in rabbits]. Yao Xue Xue Bao. 2003;38:571-3 pubmed
    ..045 0.min-1, K10 = 0.054 0.min-1, AUC = 235 mg.min.L-1, CLs = 0.043 0 L.min-1.kg-1, Vc = 0.780 L.kg-1. The pharmacokinetics of osthole after i.v. administration showed a rapid distribution and elimination process in rabbits. ..
  10. Zhang Q, Qin L, Zheng H, Huang B, Chen Y. [The computer image processing and cluster analysis on Fructus Cnidii from different habitats]. Zhong Yao Cai. 2003;26:252-4 pubmed
    ..The shape of Fructus Cnidii from different habitats varied significantly. According to the results of computer image processing and cluster analysis, Fructus Cnidii can be classified into three types. ..
  11. He Y, Qu S, Wang J, He X, Lin W, Zhen H, et al. Neuroprotective effects of osthole pretreatment against traumatic brain injury in rats. Brain Res. 2012;1433:127-36 pubmed publisher
    Osthole, a coumarin compound isolated from the plant-derived herb Cnidium monnieri, has been the subject of considerable interest because of its broad spectrum of pharmacological properties...
  12. Sun F, Xie M, Xue J, Wang H. Osthol regulates hepatic PPAR alpha-mediated lipogenic gene expression in alcoholic fatty liver murine. Phytomedicine. 2010;17:669-73 pubmed publisher
    Our previous studies found that osthol, an active constituent isolated from Cnidium monnieri (L...
  13. Kim S, Chang B, Han S, Hwang B, Kim S, Lee M. A new phenolic glycoside from Cnidium monnieri fruits. Nat Prod Res. 2013;27:1945-8 pubmed publisher
    ..8), 8-methoxy-xanthotoxol-5-?-glucoside (9) and marmesinin (10) were isolated from n-BuOH-soluble fraction of Cnidium monnieri fruits. All the isolated compounds, however, exerted little immunomodulatory effect in RAW 264.7 cells.
  14. Deng S, May B, Zhang A, Lu C, Xue C. Topical herbal medicine combined with pharmacotherapy for psoriasis: a systematic review and meta-analysis. Arch Dermatol Res. 2013;305:179-89 pubmed publisher
    ..Studies that address the identified methodological deficiencies are required to further investigate the efficacy and safety of these HMs as adjunct therapies for psoriasis. ..
  15. Wei R, Huo H, Li X, Zhou A, Shen H, Tian J. [Study on antiinflammatory effect of a compound TCM agent containing ant extractive in animal models]. Zhongguo Zhong Yao Za Zhi. 2002;27:215-8 pubmed
    ..TCM agent has significant antiinflammatory effects on the three above mentioned animal models. ..
  16. Wu H, Wang Y, Xu H, Wei M, He Q, Li M, et al. Osthole, a Coumadin Analog from Cnidium monnieri (L.) Cusson, Ameliorates Nucleus Pulposus-Induced Radicular Inflammatory Pain by Inhibiting the Activation of Extracellular Signal-Regulated Kinase in Rats. Pharmacology. 2017;100:74-82 pubmed publisher
    ..Osthole exerts analgesic effect on radicular inflammatory pain in LDH rat model, by down-regulating the mRNA expression of the target gene of COX-2 via inhibiting ERK activation in the spinal dorsal horn. ..
  17. Kwak D, Kim J, Kim J, Jeong H, Keum K, Han S, et al. Anti-angiogenic activities of Cnidium officinale Makino and Tabanus bovinus. J Ethnopharmacol. 2002;81:373-9 pubmed
    This study investigated the anti-angiogenic activities of Cnidium officinale Makino and Tabanus bovinus by using cultured glomerular capillary endothelial cells (GECs), chorioallantoic membrane (CAM) and rat cornea...
  18. Yang X, Yang S, Zhang X. [Chromatographic fingerprint of Cnidium monnieri]. Yao Xue Xue Bao. 2007;42:877-81 pubmed
    To establish the method of HPLC-fingerprint analysis for the quality control of Cnidium monnieri L. Cuss...
  19. Sang H, An T, Kim C, Shin G, Sung G, Yu S. Two novel Talaromyces species isolated from medicinal crops in Korea. J Microbiol. 2013;51:704-8 pubmed publisher
    ..angelicus and T. cnidii, were collected from the medicinal crops Angelica gigas and Cnidium officinale, respectively, in Korea...
  20. Tsukamoto T, Ishikawa Y, Miyazawa M. Larvicidal and adulticidal activity of alkylphthalide derivatives from rhizome of Cnidium officinale against Drosophila melanogaster. J Agric Food Chem. 2005;53:5549-53 pubmed
    The insecticidal activity of the chloroform extract of Cnidium officinale rhizomes and its constituents was investigated against larvae and adults of Drosophila melanogaster and compared with that of rotenone...
  21. Wang D, Chen L, Liu J, Wang X, Wu Y, Fang M, et al. On-line two-dimensional countercurrent chromatography×high performance liquid chromatography system with a novel fragmentary dilution and turbulent mixing interface for preparation of coumarins from Cnidium monnieri. J Chromatogr A. 2015;1406:215-23 pubmed publisher
    ..liquid chromatography (2D CCC×HPLC) system for one-step preparative isolation of coumarins from the fruits of Cnidium monnieri...
  22. Kim J, Son D, Lee P, Lee K, Kim H, Kim S. Ethyl acetate soluble fraction of Cnidium officinale MAKINO inhibits neuronal cell death by reduction of excessive nitric oxide production in lipopolysaccharide-treated rat hippocampal slice cultures and microglia cells. J Pharmacol Sci. 2003;92:74-8 pubmed
    In the present work, we found that the ethyl acetate-soluble fraction of Cnidium officinale MAKINO (COEA) decreased nitric oxide (NO) production in the lipopolysaccharide (LPS)-stimulated BV-2 and primary microglia and suppressed ..
  23. Park H, Ju E, Jo S, Jung U, Kim S. HemoHIM enhances the therapeutic efficacy of ionizing radiation treatment in tumor-bearing mice. J Med Food. 2010;13:47-53 pubmed publisher
    ..the ethanol-insoluble fraction to the total water extract of a mixture of three edible herbs-Angelica Radix, Cnidium Rhizoma, and Paeonia Radix. Anticancer effects of HemoHIM were evaluated in melanoma-bearing mice exposed to IR...
  24. Yoo R, Zhao F, Lim S, Igori D, Kim S, An T, et al. The complete genome sequences of two isolates of cnidium vein yellowing virus, a tentative new member of the family Secoviridae. Arch Virol. 2015;160:2911-4 pubmed publisher
    We determined the complete genome sequences of two isolates of cnidium vein yellowing virus (CnVYV-1 and -2) that co-infected all field samples collected from Cnidium officinale in Korea...
  25. Wang J, Fu Y, Wei Z, He X, Shi M, Kou J, et al. Anti-asthmatic activity of osthole in an ovalbumin-induced asthma murine model. Respir Physiol Neurobiol. 2017;239:64-69 pubmed publisher
    Osthole, an active coumarin extracted from the dried fruits of Cnidium monnieri (L.) Cusson, is known to possess a variety of pharmacological activities...
  26. Chae S, Kim S, Yeon S, Lee S, Ahn Y. Adulticidal activity of phthalides identified in Cnidium officinale rhizome to B- and Q-biotypes of Bemisia tabaci. J Agric Food Chem. 2011;59:8193-8 pubmed publisher
    ..Z)-butylidenephthalide (1), (3S)-butylphthalide (2), and (Z)-ligustilide (3) identified in the rhizome of Cnidium officinale (Apiaceae) to B- and Q-biotype females of Bemisia tabaci was evaluated using a leaf-dip bioassay...
  27. Shen L, Jin L, Zhang D, Xue G. [Effect of osthol on memory impairment of mice in AlCl3-induced acute senile model]. Yao Xue Xue Bao. 2002;37:178-80 pubmed
    ..Perhaps the mechanism is involved in enhancing the activities of GSH-PX and SOD, clearing away the free radical, protecting the brain neuron from the harm of lipoperoxide. ..
  28. Jeong S, Kwak D, Lee S, Choo Y, Woo W, Keum K, et al. Inhibitory effects of Cnidium officinale Makino and Tabanus fulvus Meigan on the high glucose-induced proliferation of glomerular mesangial cells. Phytomedicine. 2005;12:648-55 pubmed
    This study describes a potent activity of Cnidium officinale Makino (Cnidii rhizoma) and Tabanus fulvus Meigan (Tabanus) as an inhibitor of high glucose-induced proliferation of glomerular mesangial cells (GMCs)...
  29. Zhou Z, Liu P. [Progress in study of chemical constituents and anti-tumor activities of Cnidium monnieri]. Zhongguo Zhong Yao Za Zhi. 2005;30:1309-13 pubmed
    The main pharmacological constituents of Chinese traditional medicine herb Cnidium monnieri are coumarin compounds and volatile oil...
  30. Lee W, Shin J, Jang D, Lee K. Cnidilide, an alkylphthalide isolated from the roots of Cnidium officinale, suppresses LPS-induced NO, PGE2, IL-1?, IL-6 and TNF-? production by AP-1 and NF-?B inactivation in RAW 264.7 macrophages. Int Immunopharmacol. 2016;40:146-155 pubmed publisher
    Cnidilide, an alkyl phthalide isolated from the rhizome of Cnidium officinale, has been reported to possess antispasmodic and sedative effects...
  31. Chen C. Computational screening and design of traditional Chinese medicine (TCM) to block phosphodiesterase-5. J Mol Graph Model. 2009;28:261-9 pubmed publisher
    The traditional Chinese medicines (TCM), Epimedium sagittatum (ESs), Cnidium monnieri (CMs), and Semen cuscutae (SCs), were used for treating erectile dysfunction since the ancient Han dynasty (202 BC-AD 220)...
  32. Duan J, Yang Y, Liu H, Dou P, Tan S. Osthole ameliorates acute myocardial infarction in rats by decreasing the expression of inflammatory-related cytokines, diminishing MMP-2 expression and activating p-ERK. Int J Mol Med. 2016;37:207-16 pubmed publisher
    Osthole, the active constituent of Cnidium monnieri extracts, has been shown to have a diverse range of pharmacological properties...
  33. Kimura Y, Sumiyoshi M, Taniguchi M, Baba K. Antitumor actions of a chromone glucoside cnidimoside A isolated from Cnidium japonicum. J Nat Med. 2008;62:308-13 pubmed publisher
    ..In the present study, we examined the effects of a chromone glucoside cnidimoside A isolated from Cnidium japonicum whole plants on tumor growth and tumor metastasis in colon 26-bearing mice...
  34. Lia H, Chen F. Preparative isolation and purification of bergapten and imperatorin from the medicinal plant Cnidium monnieri using high-speed counter-current chromatography by stepwise increasing the flow-rate of the mobile phase. J Chromatogr A. 2004;1061:51-4 pubmed
    ..for the preparative separation and purification of bergapten and imperatorin from the Chinese medicinal plant Cnidium monnieri (L.) Cusson...
  35. Liao P, Chien S, Ho C, Wang E, Lee S, Kuo Y, et al. Osthole regulates inflammatory mediator expression through modulating NF-?B, mitogen-activated protein kinases, protein kinase C, and reactive oxygen species. J Agric Food Chem. 2010;58:10445-51 pubmed publisher
    ..In this study we isolated osthole from the seeds of Cnidium monnieri and demonstrated that osthole inhibited TNF-?, NO and COX-2 expression in LPS-stimulated macrophages, ..
  36. Chang B, Kim D, Kim H, Kim S. Evaluation of estrogenic potential by herbal formula, HPC 03 for in vitro and in vivo. Reproduction. 2018;155:105-115 pubmed publisher
    HPC 03 is herbal formula that consists of extracts from Angelica gigas, Cnidium officinale Makino and Cinnamomum cassia Presl...
  37. Zhang Q, Qin L, Zheng H, Huang B, Nian H, Chen L. [Analysis on intraspecific variation of Cnidium monnieri by RAPD]. Zhong Yao Cai. 2004;27:469-71 pubmed
    To study the genetic variation of Cnidium monnieri from different regions...
  38. Beom Kim S, Kim C, Liu Q, Hee Jo Y, Joo Choi H, Hwang B, et al. Optimization of extraction conditions for osthol, a melanogenesis inhibitor from Cnidium monnieri fruits. Pharm Biol. 2016;54:1373-9 pubmed publisher
    ..The melanogenesis inhibitory activity of osthol, a major coumarin of the fruits of Cnidium monnieri Cusson (Umbelliferae), and optimized extraction conditions for the maximum yield from the isolation of ..
  39. Liu R, Feng L, Sun A, Kong L. Preparative isolation and purification of coumarins from Cnidium monnieri (L.) Cusson by high-speed counter-current chromatography. J Chromatogr A. 2004;1055:71-6 pubmed
    A high-speed counter-current chromatography (HSCCC) method for separation and purification of coumarins from Cnidium monnieri (L...
  40. Chou S, Hsu C, Wang K, Wang M, Wang C. Antitumor effects of Osthol from Cnidium monnieri: an in vitro and in vivo study. Phytother Res. 2007;21:226-30 pubmed
    b>Cnidium monnieri (L.) Cusson is a Chinese medicine which is used widely by traditional medicine doctors. Osthol is a major bio-activity compound of the herb. In this study, osthol was isolated from C...
  41. Islam M, Yoo H, Sung C, Dong M, Park Y, Jin C, et al. Simultaneous determination of phenolic acids and phthalide compounds by liquid chromatography for quality assessment of Rhizoma cnidii. J AOAC Int. 2009;92:375-81 pubmed
    ..74-4.39, and 0.32-1.14 mg/g herb, respectively. Thus, the developed method was found to be accurate and reproducible and is considered suitable for the qualitative and quantitative analysis of Rhizoma Cnidii for bioactive compounds. ..
  42. Dien P, Nhan N, Le Thuy H, Quang D. Main constituents from the seeds of Vietnamese Cnidium monnieri and cytotoxic activity. Nat Prod Res. 2012;26:2107-11 pubmed publisher
    From the ethyl acetate extract of the seeds of Vietnamese Cnidium monnieri L., three coumarins, osthole (1), xanthotoxin (2), imperatorin (3) and a sterol, daucosterol (4) have been purified...
  43. Jo S, Lee H, Kim S, Kim J, Bae C, Jung U, et al. Antiinflammatory activity of an herbal preparation (HemoHIM) in rats. Phytother Res. 2007;21:625-8 pubmed
    ..These results demonstrate that the HemoHIM has a potent antiinflammatory effect. ..
  44. Lee S, Kim J, Kang K, Hwang Y, Jeong G, Jo S, et al. Herbal preparation (HemoHIM) enhanced functional maturation of bone marrow-derived dendritic cells mediated toll-like receptor 4. BMC Complement Altern Med. 2016;16:67 pubmed publisher
    HemoHIM, which is an herbal preparation of three edible herbs (Angelicam gigas Nakai, Cnidium offinale Makino, and Peaonia japonica Miyabe), is known to have various biological and immunological activities, but the modulatory effects of ..
  45. Fusi F, Sgaragli G, Ha L, Cuong N, Saponara S. Mechanism of osthole inhibition of vascular Ca(v)1.2 current. Eur J Pharmacol. 2012;680:22-7 pubmed publisher
    Osthole is a coumarin extracted from Cnidium monnieri (L.) Cusson. The medicinal plant is widely used in Vietnamese as well as Chinese traditional medicine as a vasodilating and antihypertensive agent...
  46. Saba E, Lee C, Jeong D, Lee K, Kim T, Roh S, et al. Fermented rice bran prevents atopic dermatitis in DNCB-treated NC/Nga mice. J Biomed Res. 2016;30:334-43 pubmed publisher
    ..In our study, rice bran along with oriental medicinal plants (Angelicae gigantis, Cnidium officinale, Artemisia princeps, and Camellia sinensis) was fermented by Lactobacillus rhamnosus and Pichia ..
  47. Lee W, Lin R, Lin S, Chen Y, Lin H, Liang Y. Osthole enhances glucose uptake through activation of AMP-activated protein kinase in skeletal muscle cells. J Agric Food Chem. 2011;59:12874-81 pubmed publisher
    ..Therefore, osthole might have potential as an antidiabetic agent for treating diabetes. ..
  48. Qi Z, Xue J, Zhang Y, Wang H, Xie M. Osthole ameliorates insulin resistance by increment of adiponectin release in high-fat and high-sucrose-induced fatty liver rats. Planta Med. 2011;77:231-5 pubmed publisher
    ..These results revealed that osthole could improve the IR induced by high-fat and high-sucrose emulsion in fatty liver rats, and its mechanism might be associated with increment of adiponectin release via activation of PPAR ?/ ? pathway. ..
  49. Oh H, Kim J, Song E, Cho H, Kim D, Park S, et al. Sesquiterpenes with hepatoprotective activity from Cnidium monnieri on tacrine-induced cytotoxicity in Hep G2 cells. Planta Med. 2002;68:748-9 pubmed
    Bioassay-guided fractionation of the EtOH extract of Cnidium monnieri (Apiaceae) furnished two hepatoprotective sesquiterpenes, torilin (1) and torilolone (2), together with a new derivative, 1-hydroxytorilin (3)...
  50. You L, An R, Wang X, Li Y. Discovery of novel osthole derivatives as potential anti-breast cancer treatment. Bioorg Med Chem Lett. 2010;20:7426-8 pubmed publisher
    Osthole, an ingredient of Traditional Chinese Medicine (TCM) from natural product Cnidium monnieri (L.) Cusson, was used as a lead compound for structural modification...
  51. Ogawa H, Sasai N, Kamisako T, Baba K. Effects of osthol on blood pressure and lipid metabolism in stroke-prone spontaneously hypertensive rats. J Ethnopharmacol. 2007;112:26-31 pubmed
    Osthol, a coumarin compound, was isolated from the dried fruits of Cnidium monnieri (Umbelliferae) and the effect of dietary osthol on hypertension and lipid metabolism was examined in stroke-prone spontaneously hypertensive rats (SHRSP)...
  52. Ku S, Kim H, Kim J, Kang K, Lee H. Ameliorating effects of herbal formula hemomine on experimental subacute hemorrhagic anemia in rats. J Ethnopharmacol. 2017;198:205-213 pubmed publisher
    ..HM) is an herbal mixture consisting of 5 varieties of the hematopoietic herbal extracts (Angelica gigas Nakai, Cnidium officinale Makino, Paeonia lactiflora Pall...
  53. Choi E, Yoon J, Han B, Jeong D, Lee Y, Kang D, et al. Ligustilide attenuates vascular inflammation and activates Nrf2/HO-1 induction and, NO synthesis in HUVECs. Phytomedicine. 2018;38:12-23 pubmed publisher
    Ligustilide is a bioactive phthalide derivative isolated from Cnidii Rhizoma (Cnidium officinale, rhizome) and Angelicae Gigantis Radix (Angelica gigas Nakai, root) which are both medicinal herbs used to treat circulatory disorders...