centella

Summary

Summary: A plant of the family APIACEAE which is the source of asiatic acid and asiaticoside. Centella asiatica (L.) Urb. = Hydrocotyle asiatica L. is known for effect on peripheral circulation.

Top Publications

  1. Sharma J, Sharma R. Radioprotection of Swiss albino mouse by Centella asiatica extract. Phytother Res. 2002;16:785-6 pubmed
    b>Centella asiatica, has a considerable reputation in the Indian system of medicine. It is a rasayan (general tonic), brain tonic, improves memory and strengthens the CNS...
  2. Gupta R, Flora S. Effect of Centella asiatica on arsenic induced oxidative stress and metal distribution in rats. J Appl Toxicol. 2006;26:213-22 pubmed
    Concomitant oral supplementation of Centella asiatica (100, 200 or 300 mg kg(-1), orally once daily) during arsenic exposure (20 ppm in drinking water for 4 weeks) was investigated in rats for its protective value...
  3. Kim O, Kim S, Ohyama K, Muranaka T, Choi Y, Lee H, et al. Upregulation of phytosterol and triterpene biosynthesis in Centella asiatica hairy roots overexpressed ginseng farnesyl diphosphate synthase. Plant Cell Rep. 2010;29:403-11 pubmed publisher
    ..15-fold after 14 days of MJ treatment. This result may indicate that FPS performs a role not only in phytosterol regulation, but also in triterpene biosynthesis. ..
  4. Sastravaha G, Gassmann G, Sangtherapitikul P, Grimm W. Adjunctive periodontal treatment with Centella asiatica and Punica granatum extracts in supportive periodontal therapy. J Int Acad Periodontol. 2005;7:70-9 pubmed
    b>Centella asiatica and Punica granatum are medicinal plants that have been reported to promote tissue healing and modulate host responses...
  5. Veerendra Kumar M, Gupta Y. Effect of different extracts of Centella asiatica on cognition and markers of oxidative stress in rats. J Ethnopharmacol. 2002;79:253-60 pubmed
    b>Centella asiatica, a plant mentioned in Indian literature has been described to possess CNS effects such as stimulatory-nervine tonic, rejuvenant, sedative, tranquilizer and intelligence promoting property...
  6. Mangas S, Moyano E, Osuna L, Cusido R, Bonfill M, Palazon J. Triterpenoid saponin content and the expression level of some related genes in calli of Centella asiatica. Biotechnol Lett. 2008;30:1853-9 pubmed publisher
    b>Centella asiatica has been extensively studied but there has been no report to date that relates gene expression and centelloside production in non-differentiated tissues...
  7. Yoshida M, Fuchigami M, Nagao T, Okabe H, Matsunaga K, Takata J, et al. Antiproliferative constituents from Umbelliferae plants VII. Active triterpenes and rosmarinic acid from Centella asiatica. Biol Pharm Bull. 2005;28:173-5 pubmed
    The antiproliferative constituents in the MeOH extract from the aerial parts of Centella asiatica were investigated...
  8. Paocharoen V. The efficacy and side effects of oral Centella asiatica extract for wound healing promotion in diabetic wound patients. J Med Assoc Thai. 2010;93 Suppl 7:S166-70 pubmed
    To study clinical efficacy and side effects of the oral Centella asiatica extract capsule in the diabetic wound healing. And to study the side effects of Centella asiatica extract capsule...
  9. Satheesan J, Narayanan A, Sakunthala M. Induction of root colonization by Piriformospora indica leads to enhanced asiaticoside production in Centella asiatica. Mycorrhiza. 2012;22:195-202 pubmed publisher
    b>Centella asiatica (Indian pennywort) has wide application in Indian and Chinese traditional medicines with documented evidence for wound healing and neuroprotective and anti-aging potential...

More Information

Publications62

  1. Soumyanath A, Zhong Y, Gold S, Yu X, Koop D, Bourdette D, et al. Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in-vitro. J Pharm Pharmacol. 2005;57:1221-9 pubmed
    Axonal regeneration is important for functional recovery following nerve damage. Centella asiatica Urban herb, also known as Hydrocotyle asiatica L., has been used in Ayurvedic medicine for centuries as a nerve tonic...
  2. Saxena G, Flora S. Changes in brain biogenic amines and haem biosynthesis and their response to combined administration of succimers and Centella asiatica in lead poisoned rats. J Pharm Pharmacol. 2006;58:547-59 pubmed
    ..its monoesters, monoisoamyl DMSA (MiADMSA), individually or when administered in combination with an extract of Centella asiatica against experimental lead intoxication in rats...
  3. Matsuda H, Morikawa T, Ueda H, Yoshikawa M. Medicinal foodstuffs. XXVII. Saponin constituents of gotu kola (2): structures of new ursane- and oleanane-type triterpene oligoglycosides, centellasaponins B, C, and D, from Centella asiatica cultivated in Sri Lanka. Chem Pharm Bull (Tokyo). 2001;49:1368-71 pubmed
    ..oleanane-type triterpene oligoglycosides, centellasaponins B, C, and D, were isolated from the aerial parts of Centella asiatica (L...
  4. James J, Dubery I. Pentacyclic triterpenoids from the medicinal herb, Centella asiatica (L.) Urban. Molecules. 2009;14:3922-41 pubmed publisher
    b>Centella asiatica accumulates large quantities of pentacyclic triterpenoid saponins, collectively known as centelloids...
  5. Klovekorn W, Tepe A, Danesch U. A randomized, double-blind, vehicle-controlled, half-side comparison with a herbal ointment containing Mahonia aquifolium, Viola tricolor and Centella asiatica for the treatment of mild-to-moderate atopic dermatitis. Int J Clin Pharmacol Ther. 2007;45:583-91 pubmed
    ..An ointment containing extracts from Mahonia aquifolium, Viola tricolor and Centella asiatica has previously been studied in open uncontrolled trials with children...
  6. Rakotoniriana E, Munaut F, Decock C, Randriamampionona D, Andriambololoniaina M, Rakotomalala T, et al. Endophytic fungi from leaves of Centella asiatica: occurrence and potential interactions within leaves. Antonie Van Leeuwenhoek. 2008;93:27-36 pubmed
    Fungal endophytes were isolated from leaves of Centella asiatica (Apiaceae) collected at Mangoro (middle eastern region of Madagascar, 200 km from Antananarivo). Forty- five different taxa were recovered...
  7. Gnanapragasam A, Yogeeta S, Subhashini R, Ebenezar K, Sathish V, Devaki T. Adriamycin induced myocardial failure in rats: protective role of Centella asiatica. Mol Cell Biochem. 2007;294:55-63 pubmed
    ..The present study was aimed to evaluate the efficacy of Centella asiatica on the mitochondrial enzymes; mitochondrial antioxidant status in adriamycin induced myocardial injury...
  8. Park B, Bosire K, Lee E, Lee Y, Kim J. Asiatic acid induces apoptosis in SK-MEL-2 human melanoma cells. Cancer Lett. 2005;218:81-90 pubmed
    Asiatic acid (AA) is a pentacyclic triterpene found in Centella asiatica. In the present study, the mechanism of anticancer effect of AA on skin cancer was investigated...
  9. Forte R, Cennamo G, Finelli M, Bonavolonta P, de Crecchio G, Greco G. Combination of flavonoids with Centella asiatica and Melilotus for diabetic cystoid macular edema without macular thickening. J Ocul Pharmacol Ther. 2011;27:109-13 pubmed publisher
    The purpose of this study was to evaluate the orally administered combination of flavonoids desmin and troxerutin with Centella asiatica and Melilotus for the treatment of diabetic cystoid macular edema (CME) without macular thickening.
  10. Satake T, Kamiya K, An Y, Oishi Nee Taka T, Yamamoto J. The anti-thrombotic active constituents from Centella asiatica. Biol Pharm Bull. 2007;30:935-40 pubmed
    The in vitro effects of a methanol extract from the aerial parts of Centella asiatica on shear-induced platelet activation and coagulation were assessed after oral administration to rats, by subjecting non-anticoagulated blood to ..
  11. Wattanathorn J, Mator L, Muchimapura S, Tongun T, Pasuriwong O, Piyawatkul N, et al. Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica. J Ethnopharmacol. 2008;116:325-32 pubmed publisher
    b>Centella asiatica has a reputation to restore decline cognitive function in traditional medicine and in animal model. However, little evidence regarding the efficacy of Centella asiatica from systematized trials is available...
  12. Sastravaha G, Yotnuengnit P, Booncong P, Sangtherapitikul P. Adjunctive periodontal treatment with Centella asiatica and Punica granatum extracts. A preliminary study. J Int Acad Periodontol. 2003;5:106-15 pubmed
    b>Centella asiatica and Punica granatum are medicinal herbs that have been reported to promote tissue healing and modulate host responses. The purpose of this study was to investigate the effects of the combined extracts from C...
  13. Sainath S, Meena R, Supriya C, Reddy K, Reddy P. Protective role of Centella asiatica on lead-induced oxidative stress and suppressed reproductive health in male rats. Environ Toxicol Pharmacol. 2011;32:146-54 pubmed publisher
    b>Centella asiatica has been mentioned in ancient ayurvedic text of the Indian system of medicine for its properties to promote intelligence. The objective of the present study was to investigate the beneficial effects of C...
  14. Pan Y, Abd Rashid B, Ismail Z, Ismail R, Mak J, Pook P, et al. In vitro modulatory effects on three major human cytochrome P450 enzymes by multiple active constituents and extracts of Centella asiatica. J Ethnopharmacol. 2010;130:275-83 pubmed publisher
    b>Centella asiatica (CA) has been widely cultivated as a vegetable or spice in China, Southeast Asia, India, Sri Lanka, Africa, and Oceanic countries and traditionally used for wound healing and maintaining normal blood pressure...
  15. Rumalla C, Ali Z, Weerasooriya A, Smillie T, Khan I. Two new triterpene glycosides from Centella asiatica. Planta Med. 2010;76:1018-21 pubmed publisher
    Phytochemical investigation of the leaves of Centella asiatica resulted in the isolation and characterization of eight triterpenes and/or saponins [which were characterized as 23- O-acetylmadecassoside (1), asiatic acid (2), madecassic ..
  16. Cataldi A, Gasbarro V, Viaggi R, Soverini R, Gresta E, Mascoli F. [Effectiveness of the combination of alpha tocopherol, rutin, melilotus, and centella asiatica in the treatment of patients with chronic venous insufficiency]. Minerva Cardioangiol. 2001;49:159-63 pubmed
    The aim of this comparative clinical study was to evaluate the efficacy of the association of alphatocopherol, rutin, melilotus officinalis, and centella asiatica with oral administration in patients with chronic venous insufficiency.
  17. Moghaddam S, Jaafar H, Ibrahim R, Rahmat A, Aziz M, Philip E. Effects of acute gamma irradiation on physiological traits and flavonoid accumulation of Centella asiatica. Molecules. 2011;16:4994-5007 pubmed publisher
    In the present study, two accessions of Centella asiatica (CA03 and CA23) were subjected to gamma radiation to examine the response of these accessions in terms of survival rate, flavonoid contents, leaf gas exchange and leaf mass...
  18. Puttarak P, Panichayupakaranant P. Factors affecting the content of pentacyclic triterpenes in Centella asiatica raw materials. Pharm Biol. 2012;50:1508-12 pubmed publisher
    ..mainly, asiatic acid, madecassic acid, asiaticoside, and madecassoside are the active constituents of Centella asitica (L.) Urban. (Apiaceae)...
  19. Barbosa N, Pittella F, Gattaz W. Centella asiatica water extract inhibits iPLA2 and cPLA2 activities in rat cerebellum. Phytomedicine. 2008;15:896-900 pubmed publisher
    b>Centella asiatica (L.) Urb an is distributed widely in South America and Asia and is known as a therapeutic agent in folk medicine, capable of improving memory and treating several neurological disorders...
  20. Coldren C, Hashim P, Ali J, Oh S, Sinskey A, Rha C. Gene expression changes in the human fibroblast induced by Centella asiatica triterpenoids. Planta Med. 2003;69:725-32 pubmed
    ..the diverse biological activity of the triterpeniod compounds isolated from the tropical medicinal plant Centella asiatica were studied with gene microarrays and real-time reverse transcription polymerase chain reaction (real-..
  21. Ahmad Rather M, Justin Thenmozhi A, Manivasagam T, Dhivya Bharathi M, Essa M, Guillemin G. Neuroprotective role of Asiatic acid in aluminium chloride induced rat model of Alzheimer's disease. Front Biosci (Schol Ed). 2018;10:262-275 pubmed
    ..The current investigation explored the neuroprotective potential of asiatic acid (AA), a natural triterpene of Centella asiatica on aluminium chloride (AlCl3) induced rat model of AD...
  22. He W, Dai J, Ye M, Wu L, Guo D. Microbial transformation of asiatic acid by Alternaria longipes. J Asian Nat Prod Res. 2010;12:760-4 pubmed publisher
    Asiatic acid is a major pentacyclic triterpene isolated from Centella asiatica. It shows a variety of bioactivities...
  23. Punturee K, Wild C, Kasinrerk W, Vinitketkumnuen U. Immunomodulatory activities of Centella asiatica and Rhinacanthus nasutus extracts. Asian Pac J Cancer Prev. 2005;6:396-400 pubmed
    b>Centella asiatica (CA) and Rhinacanthus nasutus (RN )have been used for treatment of various illnesses, but the mechanisms of action remain largely unknown...
  24. Apichartsrangkoon A, Wongfhun P, Gordon M. Flavor characterization of sugar-added pennywort (Centella asiatica L.) juices treated with ultra-high pressure and thermal processes. J Food Sci. 2009;74:C643-6 pubmed publisher
    ..Therefore, to preserve all aroma and active components in this juice, a nonthermal process such as ultra-high pressure should be a more appropriate technique for retention of its nutritive values than pasteurization and sterilization. ..
  25. Ngamwonglumlert L, Devahastin S, Chiewchan N. Molecular structure, stability and cytotoxicity of natural green colorants produced from Centella asiatica L. leaves treated by steaming and metal complexations. Food Chem. 2017;232:387-394 pubmed publisher
    Stability of extracts from Centella asiatica L. leaves treated by steaming and metal-chlorophylls complexations against combined acid-heat was compared with that from untreated leaves and synthetic colorant...
  26. Bunpo P, Kataoka K, Arimochi H, Nakayama H, Kuwahara T, Bando Y, et al. Inhibitory effects of Centella asiatica on azoxymethane-induced aberrant crypt focus formation and carcinogenesis in the intestines of F344 rats. Food Chem Toxicol. 2004;42:1987-97 pubmed
    Effects of the water extract of Centella asiatica Linn. on formation of azoxymethane (AOM)-induced aberrant crypt foci (ACF) and intestinal tumorigenesis in male F344 rats were investigated...
  27. Jia G, Lu X. Enrichment and purification of madecassoside and asiaticoside from Centella asiatica extracts with macroporous resins. J Chromatogr A. 2008;1193:136-41 pubmed publisher
    ..of five macroporous resins for the enrichment and purification of asiaticoside and madecassoside from Centella asiatica extracts have been evaluated...
  28. Nataraj J, Manivasagam T, Justin Thenmozhi A, Essa M. Neuroprotective effect of asiatic acid on rotenone-induced mitochondrial dysfunction and oxidative stress-mediated apoptosis in differentiated SH-SYS5Y cells. Nutr Neurosci. 2017;20:351-359 pubmed publisher
    ..Asiatic acid (AA) is a triterpene extracted from Centella asiatica has been reported as an antioxidant and anti-inflammatory agent, that offers neuroprotection against ..
  29. Chanana P, Kumar A. Possible Involvement of Nitric Oxide Modulatory Mechanisms in the Neuroprotective Effect of Centella asiatica Against Sleep Deprivation Induced Anxiety Like Behaviour, Oxidative Damage and Neuroinflammation. Phytother Res. 2016;30:671-80 pubmed publisher
    ..b>Centella asiatica (CA) is a psychoactive medicinal herb with immense therapeutic potential...
  30. Costa C, Amorim B, de Magalhães P, De Luca Canto G, Acevedo A, Guerra E. Effects of Plants on Osteogenic Differentiation and Mineralization of Periodontal Ligament Cells: A Systematic Review. Phytother Res. 2016;30:519-31 pubmed publisher
    ..in the selected studies, which were Morinda citrifolia, Aloe vera, Fructus cnidii, Zanthoxylum schinifolium, Centella asiatica, and Epimedium species...
  31. Saoji S, Raut N, Dhore P, Borkar C, Popielarczyk M, Dave V. Preparation and Evaluation of Phospholipid-Based Complex of Standardized Centella Extract (SCE) for the Enhanced Delivery of Phytoconstituents. AAPS J. 2016;18:102-14 pubmed publisher
    In the present study, a phospholipid-based complex of standardized Centella extract (SCE) was developed with a goal of improving the bioavailability of its phytoconstituents...
  32. Yao C, Yeh J, Chen Y, Li M, Huang C. Wound-healing effect of electrospun gelatin nanofibres containing Centella asiatica extract in a rat model. J Tissue Eng Regen Med. 2017;11:905-915 pubmed publisher
    b>Centella asiatica (CA) is a traditional herbal medicine that has been shown to exert pharmacological effects on wound healing...
  33. Nugroho A, Lindawati N, Herlyanti K, Widyastuti L, Pramono S. Anti-diabetic effect of a combination of andrographolide-enriched extract of Andrographis paniculata (Burm f.) Nees and asiaticoside-enriched extract of Centella asiatica L. in high fructose-fat fed rats. Indian J Exp Biol. 2013;51:1101-8 pubmed
    ..It can be concluded that its antidiabetic effect was better than that of single treatment of AEEAP or AEECA. That combination was also potential to develop as a blood glucose-lowering agent for diabetic patients. ..
  34. Jayathirtha M, Mishra S. Preliminary immunomodulatory activities of methanol extracts of Eclipta alba and Centella asiatica. Phytomedicine. 2004;11:361-5 pubmed
    ..Regressed values revealed maximum linearity in the case of the phagocytic index, moderate linearity in the total WBC count and lowest linearity in the antibody response. ..
  35. Lin X, Huang R, Zhang S, Wei L, Zhuo L, Wu X, et al. Beneficial effects of asiaticoside on cognitive deficits in senescence-accelerated mice. Fitoterapia. 2013;87:69-77 pubmed publisher
    ..Thus, AHS should be developed as a new drug to prevent age-related cognitive deficits. ..
  36. Li D, Zheng X, Duan L, Deng S, Ye W, Wang A, et al. Ethnobotanical survey of herbal tea plants from the traditional markets in Chaoshan, China. J Ethnopharmacol. 2017;205:195-206 pubmed publisher
    ..47 times mentioned), Hedyotis diffusa Willd. (46), Plantago asiatica L. (43), Houttuynia cordata Thunb (42), Centella asiatica (L.) Urban (36), Desmodium styracifolium (Osbeck) Merr. (35) and Morus alba L...
  37. Gopi M, Arambakkam Janardhanam V. Asiaticoside: Attenuation of rotenone induced oxidative burden in a rat model of hemiparkinsonism by maintaining the phosphoinositide-mediated synaptic integrity. Pharmacol Biochem Behav. 2017;155:1-15 pubmed publisher
    Asiaticoside (AS), a triterpenoid saponin isolated from the Indian medicinal herb Centella asiatica is known to exert a neuroprotective effect by attenuating the neurobehavioral, neurochemical and pathological changes in animal models...
  38. Prasad A, Prakash O, Mehrotra S, Khan F, Mathur A, Mathur A. Artificial neural network-based model for the prediction of optimal growth and culture conditions for maximum biomass accumulation in multiple shoot cultures of Centella asiatica. Protoplasma. 2017;254:335-341 pubmed publisher
    ..growth medium (Mg, Cu, Zn, nitrate and sucrose) on improved in vitro biomass yield in multiple shoot cultures of Centella asiatica...
  39. Galeone G, Spadavecchia R, Balducci M, Pagliarulo V. [The role of Proxelan in the treatment of chronic prostatitis. Results of a randomized trial]. Minerva Urol Nefrol. 2012;64:135-41 pubmed
    ..Future studies may be required to confirm our results and to explain the mechanism of action of Proxelan. ..
  40. Sirichoat A, Chaijaroonkhanarak W, Prachaney P, Pannangrong W, Leksomboon R, Chaichun A, et al. Effects of Asiatic Acid on Spatial Working Memory and Cell Proliferation in the Adult Rat Hippocampus. Nutrients. 2015;7:8413-23 pubmed publisher
    Asiatic acid is a pentacyclic triterpene from Centella asiatica. Previous studies have reported that asiatic acid exhibits antioxidant and neuroprotective activities in cell culture. It also prevents memory deficits in animal models...
  41. Xu M, Xiong Y, Liu J, Qian J, Zhu L, Gao J. Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells. Acta Pharmacol Sin. 2012;33:578-87 pubmed publisher
    To investigate whether asiatic acid (AA), a pentacyclic triterpene in Centella asiatica, exerted neuroprotective effects in vitro and in vivo, and to determine the underlying mechanisms...
  42. Ouyang Q, Pan Y, Luo H, Xuan C, Liu J, Liu J. MAD ointment ameliorates Imiquimod-induced psoriasiform dermatitis by inhibiting the IL-23/IL-17 axis in mice. Int Immunopharmacol. 2016;39:369-376 pubmed publisher
    ..Madecassoside (MAD) was the most important constituents isolated from Centella asiatica, which has long been used in dermatology, and it is supposed that MAD may have effects on psoriasis...
  43. Kim O, Kim M, Huh S, Bai D, Ahn J, Hwang B. Cloning of a cDNA probably encoding oxidosqualene cyclase associated with asiaticoside biosynthesis from Centella asiatica (L.) Urban. Plant Cell Rep. 2005;24:304-11 pubmed
    A homology-based PCR method was used to clone a cDNA encoding oxidosqualene cyclase from Centella asiatica, which produces a large quantity of triterpene saponins such as asiaticoside and madecassoside...
  44. Ramos F, Takaishi Y, Kawazoe K, Osorio C, Duque C, Acuña R, et al. Immunosuppressive diacetylenes, ceramides and cerebrosides from Hydrocotyle leucocephala. Phytochemistry. 2006;67:1143-50 pubmed
    ..Their structures were established by spectroscopic methods. The isolated compounds 1-3, 5a-g, 6a-f and 7 were shown to be active in the lipopolysaccharide (LPS) induced cytokine production assay for IL-10, IL-12, and TNF-alpha. ..
  45. Li H, Wan J, Zhang L, Zhou Q, Luo F, Zhang Z. [Inhibitiory action of asiaiticoside on collagen-induced arthritis in mice]. Yao Xue Xue Bao. 2007;42:698-703 pubmed
    ..Its active mechanism may be related to inhibiting proliferation of lymphocyte and reduction of expression of COX-2 and inflammatory cytokines. ..
  46. Paolino D, Cosco D, Cilurzo F, Trapasso E, Morittu V, Celia C, et al. Improved in vitro and in vivo collagen biosynthesis by asiaticoside-loaded ultradeformable vesicles. J Control Release. 2012;162:143-51 pubmed publisher
    ..ultradeformable vesicles as a possible topical delivery system for asiaticoside, a natural compound obtained from Centella asiatica was evaluated, because this compound exhibits collagen biosynthesis promoting activity...
  47. Prasad A, Mathur A, Singh M, Gupta M, Uniyal G, Lal R, et al. Growth and asiaticoside production in multiple shoot cultures of a medicinal herb, Centella asiatica (L.) Urban, under the influence of nutrient manipulations. J Nat Med. 2012;66:383-7 pubmed publisher
    Growth and in vitro asiaticoside accumulation in multiple shoot cultures of Centella asiatica (L.) Urban was studied as a function of nutrient manipulations in the culture media...
  48. Kwon M, Choi W, Seo Y, Kim J, Yoon C, Lim H, et al. Enhancement of the skin-protective activities of Centella asiatica L. Urban by a nano-encapsulation process. J Biotechnol. 2012;157:100-6 pubmed publisher
    Aqueous extracts of Centella asiatica L. Urban were encapsulated by an edible biopolymer, gelatin, which has no effect on their cosmetic activities. The nanoparticles were w/o-type spherical liposomes that had an average diameter of 115...
  49. Nasir M, Abdullah J, Habsah M, Ghani R, Rammes G. Inhibitory effect of asiatic acid on acetylcholinesterase, excitatory post synaptic potential and locomotor activity. Phytomedicine. 2012;19:311-6 pubmed publisher
    The asiatic acid, a triterpenoids isolated from Centella asiatica was used to delineate its inhibitory effect on acetylcholinesterase (AChE) properties, excitatory post synaptic potential (EPSP) and locomotor activity...
  50. Kim O, Kim M, Hong M, Ahn J, Hwang B. Stimulation of asiaticoside accumulation in the whole plant cultures of Centella asiatica (L.) urban by elicitors. Plant Cell Rep. 2004;23:339-44 pubmed
    The effects of a number of different elicitors on asiaticoside production in whole plant cultures of Centella asiatica were studied, including yeast extract, CdCl(2), CuCl(2) and methyl jasmonate (MJ)...
  51. Srivastava P, Yadav R. Efficacy of Natural Compounds in Neurodegenerative Disorders. Adv Neurobiol. 2016;12:107-23 pubmed publisher
    ..aimed to investigate the role of selected natural plants like Withania somnifera, Bacopa monnieri, Curcuma longa, Centella asiatica, Ocimum sanctum, Nardostachys jatamansi and Emblica officinalis in various neurodegenerative disorders ..
  52. Park J, Choi J, Son D, Park E, Song M, Hellstrom M, et al. Anti-Inflammatory Effect of Titrated Extract of Centella asiatica in Phthalic Anhydride-Induced Allergic Dermatitis Animal Model. Int J Mol Sci. 2017;18: pubmed publisher
    i>Centella asiatica has potent antioxidant and anti-inflammatory properties. However, its anti-dermatitic effect has not yet been reported...
  53. Huang Q, Huang R, Zhang S, Lin J, Wei L, He M, et al. Protective effect of genistein isolated from Hydrocotyle sibthorpioides on hepatic injury and fibrosis induced by chronic alcohol in rats. Toxicol Lett. 2013;217:102-10 pubmed publisher
    ..In conclusion, genistein exerts a preventative effect to ameliorate developing liver injury and even liver fibrosis induced by chronic alcohol administration in rats. ..