angelica

Summary

Summary: A plant genus of the family Apiaceae.

Top Publications

  1. Lee Y, Lee S, Jin J, Yun Choi H. Platelet anti-aggregatory effects of coumarins from the roots of Angelica genuflexa and A. gigas. Arch Pharm Res. 2003;26:723-6 pubmed
    ..2), isooxypeucedanin (3), oxypeucedanin hydrate (4) and osthol (5) were isolated from the MeOH extract of Angelica genuflexa in the course of searching for anti-platelet and anti-coagulant components from plants...
  2. Liao Z, Liang X, Zhu J, Zhao G, Yang M, Wang G, et al. Correlation between synergistic action of Radix Angelica dahurica extracts on analgesic effects of Corydalis alkaloid and plasma concentration of dl-THP. J Ethnopharmacol. 2010;129:115-20 pubmed publisher
    ..CA, derived from the root of Corydalis yanhusu) had potent analgesic properties, and the total coumarins of Angelica dahurica (Cou) and volatile oil (VO) that derived from the root of Radix Angelicae dahuricae all could increase ..
  3. Kang S, Lee K, Park M, Kim Y, Markelonis G, Oh T, et al. Decursin from Angelica gigas mitigates amnesia induced by scopolamine in mice. Neurobiol Learn Mem. 2003;79:11-8 pubmed
    We previously reported that a total methanolic extract of the underground part of Angelica gigas Nakai (Umbelliferae) (here-in-after abbreviated AG) significantly inhibited acetylcholinesterase (AChE) activity...
  4. Kang S, Lee K, Sung S, Kim Y. Four new neuroprotective dihydropyranocoumarins from Angelica gigas. J Nat Prod. 2005;68:56-9 pubmed
    Four new dihydropyranocoumarins were isolated from Angelica gigas roots through neuroprotective activity-guided isolation and were characterized as decursinol derivatives 4"-hydroxytigloyldecursinol (1), 4"-hydroxydecursin (2), (..
  5. Yan J, Kim D, Moon Y, Jung J, Ahn E, Baek N, et al. Protection against beta-amyloid peptide-induced memory impairment with long-term administration of extract of Angelica gigas or decursinol in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2004;28:25-30 pubmed
    We investigated the effect of long-term oral administration of ethanolic extract of Angelica gigas Nakai (Umbelliferae) (EAG) or decursinol, a coumarin isolated from A...
  6. Widelski J, Popova M, Graikou K, Glowniak K, Chinou I. Coumarins from Angelica lucida L.--antibacterial activities. Molecules. 2009;14:2729-34 pubmed publisher
    The first phytochemical investigation of the fruits of Angelica lucida has led to the isolation and characterization of five known coumarins (imperatorin, isoimperatorin, heraclenol, oxypeucedanin hydrate and heraclenin)...
  7. Shin S, Jeon J, Park D, Jang J, Joo S, Hwang B, et al. Anti-inflammatory effects of an ethanol extract of Angelica gigas in a Carrageenan-air pouch inflammation model. Exp Anim. 2009;58:431-6 pubmed
    Anti-inflammatory effects of an ethanol extract of Angelica gigas (EAG; 50, 160, or 500 mg/kg) were investigated in a carrageenan-induced air pouch inflammation model...
  8. Kim H, Sik Bang S, Seok Choi J, Han H, Kim I. Involvement of PKC and ROS in the cytotoxic mechanism of anti-leukemic decursin and its derivatives and their structure-activity relationship in human K562 erythroleukemia and U937 myeloleukemia cells. Cancer Lett. 2005;223:191-201 pubmed
    ..Decursin (1), a pyranocoumarin from Angelica gigas, exhibits the cytotoxic effects on various human cancer cell lines and in vitro PKC activation...
  9. Lee M, Seo C, Lee J, Lee N, Kim J, Ha H, et al. Anti-asthmatic effects of Angelica dahurica against ovalbumin-induced airway inflammation via upregulation of heme oxygenase-1. Food Chem Toxicol. 2011;49:829-37 pubmed publisher
    ..The present study was undertaken to assess the effects of an Angelica dahurica Bentham et Hooker ethanolic extract (AD) on airway inflammation in an ovalbumin (OVA)-induced airway ..

More Information

Publications62

  1. Moon Y, Lee J, Oh M, Pak Y, Park K, Oh T, et al. Inhibition of inflammation and oxidative stress by Angelica dahuricae radix extract decreases apoptotic cell death and improves functional recovery after spinal cord injury. J Neurosci Res. 2012;90:243-56 pubmed publisher
    ..Here, we examined the neuroprotective effects of Angelica dahuricae radix (ADR) extract after SCI...
  2. Islam M, Choi R, Jin S, Kim Y, Ahn B, Zhao D, et al. Mechanism of anti-inflammatory activity of umbelliferone 6-carboxylic acid isolated from Angelica decursiva. J Ethnopharmacol. 2012;144:175-81 pubmed publisher
    ..and anti-inflammatory activities of umbelliferone 6-carboxylic acid (UMC) isolated from the whole plants of Angelica decursiva. In this study, we elucidated the anti-inflammatory mechanisms of UMC in vitro and in vivo...
  3. Tabata K, Motani K, Takayanagi N, Nishimura R, Asami S, Kimura Y, et al. Xanthoangelol, a major chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma and leukemia cells. Biol Pharm Bull. 2005;28:1404-7 pubmed
    Xanthoangelol, a major chalcone constituent of the stem exudates of Angelica keiskei, was evaluated for cell toxicity and apoptosis-inducing activity in human neuroblastoma (IMR-32) and leukemia (Jurkat) cells...
  4. Lee J, Choi S, Lee H, Han K, Han E, Suh H. Effects of ginsenoside Rd and decursinol on the neurotoxic responses induced by kainic acid in mice. Planta Med. 2003;69:230-4 pubmed
    ..c. v. may not be directly mediated by ERK phosphorylation and CREB phosphorylation in the mouse. ..
  5. Ka M, Choi E, Chun H, Lee K. Antioxidative activity of volatile extracts isolated from Angelica tenuissimae roots, peppermint leaves, pine needles, and sweet flag leaves. J Agric Food Chem. 2005;53:4124-9 pubmed
    Volatile extracts were isolated from dried medicinal plants [Angelica tenuissimae roots (AT, Angelica tenuissima Nakai), peppermint leaves (PL, Mentha arvensis L.), pine needles (PN, Pinus sylvestris L...
  6. Yoshikawa M, Nishida N, Ninomiya K, Ohgushi T, Kubo M, Morikawa T, et al. Inhibitory effects of coumarin and acetylene constituents from the roots of Angelica furcijuga on D-galactosamine/lipopolysaccharide-induced liver injury in mice and on nitric oxide production in lipopolysaccharide-activated mouse peritoneal macropha. Bioorg Med Chem. 2006;14:456-63 pubmed
    ..p.) from the roots of Angelica furcijuga protected the liver injury induced by D-galactosamine (D-GalN)/lipopolysaccharide (LPS) in mice...
  7. Avula B, Joshi V, Reddy V L N, Choi Y, Khan I. Simultaneous determination of eight coumarins in Angelica gigas and in various other Angelica species by high performance liquid chromatography and comparative micro-morphology study of Angelica species. Planta Med. 2007;73:1509-16 pubmed
    ..for the quantitative determination of eight coumarin constituents from the methanolic extract of the roots of Angelica gigas. The coumarin constituents present in the roots of Angelica gigas were separated using an acetonitrile (0...
  8. Lee M, Lee J, Seo C, Ha H, Lee H, Son J, et al. Anti-inflammatory activity of Angelica dahurica ethanolic extract on RAW264.7 cells via upregulation of heme oxygenase-1. Food Chem Toxicol. 2011;49:1047-55 pubmed publisher
    In this study, we analyzed the anti-inflammatory effects of Angelica dahurica Bentham et Hooker ethanolic extract (ADEE) on RAW264.7 cells, to understand the mechanism underlying its observed effects...
  9. Kang S, Lee K, Koo K, Yoon J, Lim S, Kim Y, et al. ESP-102, a standardized combined extract of Angelica gigas, Saururus chinensis and Schizandra chinensis, significantly improved scopolamine-induced memory impairment in mice. Life Sci. 2005;76:1691-705 pubmed
    We assessed the effects of oral treatments of ESP-102, a standardized combined extract of Angelica gigas, Saururus chinensis and Schizandra chinensis, on learning and memory deficit...
  10. Jiang C, Lee H, Li G, Guo J, Malewicz B, Zhao Y, et al. Potent antiandrogen and androgen receptor activities of an Angelica gigas-containing herbal formulation: identification of decursin as a novel and active compound with implications for prevention and treatment of prostate cancer. Cancer Res. 2006;66:453-63 pubmed
    ..antiandrogen and AR activities of the ethanol extract of a herbal formula (termed KMKKT) containing Korean Angelica gigas Nakai (AGN) root and nine other Oriental herbs in the androgen-dependent LNCaP human prostate cancer cell ..
  11. Park H, Jo S, Jung U, Yee S. Restoration of the immune functions in aged mice by supplementation with a new herbal composition, HemoHIM. Phytother Res. 2008;22:36-42 pubmed
    ..prepared by adding the ethanol-insoluble fraction to the total water extract of a mixture of three edible herbs, Angelica Radix, Cnidium Rhizoma and Paeonia Radix...
  12. Lee S, Lee Y, Jung S, Shin K, Kim B, Kang S. Anti-tumor activities of decursinol angelate and decursin from Angelica gigas. Arch Pharm Res. 2003;26:727-30 pubmed
    The in vivo anti-tumor activities of decursinol angelate (1) and decursin (2) isolated from the roots of Angelica gigas were investigated. These two compounds, when administered consecutively for 9 days at 50 and 100 mg/kg i.p...
  13. Choi S, Ahn E, Song M, Kim D, Kang J, Kwon O, et al. In vitro GABA-transaminase inhibitory compounds from the root of Angelica dahurica. Phytother Res. 2005;19:839-45 pubmed
    The 80% aqueous MeOH extracts from the root of Angelica dahurica, found to inhibit the activities of GABA degradative enzymes GABA transaminase (GABA-T) and succinic semialdehyde dehydrogenase (SSADH), were fractionated using EtOAc, n-..
  14. Zhang J, Li L, Jiang C, Xing C, Kim S, Lu J. Anti-cancer and other bioactivities of Korean Angelica gigas Nakai (AGN) and its major pyranocoumarin compounds. Anticancer Agents Med Chem. 2012;12:1239-54 pubmed
    Korean Angelica gigas Nakai (AGN) is a major medicinal herb used in Asian countries such as Korea and China...
  15. Lee H, Lee H, Lee E, Lee J, Lee K, Kim K, et al. In vivo anti-cancer activity of Korean Angelica gigas and its major pyranocoumarin decursin. Am J Chin Med. 2009;37:127-42 pubmed
    We have reported that a 10-herbal traditional formula containing Korean Angelica gigas Nakai (AGN) exerts potent anti-cancer efficacy and identified decursin and decursinol angelate (DA) from AGN as novel anti-androgens...
  16. Park J, Park N, Xu H, Park S. Cloning and characterization of phenylalanine ammonia-lyase and cinnamate 4-hydroxylase and pyranocoumarin biosynthesis in Angelica gigas. J Nat Prod. 2010;73:1394-7 pubmed publisher
    ..also in the accumulation of decursin (1) and decursinol angelate (2), which are major secondary metabolites in Angelica gigas...
  17. Wedge D, Klun J, Tabanca N, Demirci B, Ozek T, Baser K, et al. Bioactivity-guided fractionation and GC/MS fingerprinting of Angelica sinensis and Angelica archangelica root components for antifungal and mosquito deterrent activity. J Agric Food Chem. 2009;57:464-70 pubmed publisher
    Bioassay-guided fractionation of the chloroform extract from the roots of Angelica sinensis led to isolation and characterization of (Z)-ligustilide using direct-bioautography with Colletotrichum species...
  18. Lu G, Chan K, Liang Y, Leung K, Chan C, Jiang Z, et al. Development of high-performance liquid chromatographic fingerprints for distinguishing Chinese Angelica from related umbelliferae herbs. J Chromatogr A. 2005;1073:383-92 pubmed
    A high-performance liquid chromatographic (HPLC) fingerprint of Chinese Angelica (CA) was developed basing on the consistent chromatograms of 40 CA samples (Angelica sinensis (Oliv.) Diels)...
  19. Seo Y, Kwon M, Park S, Sim Y, Choi S, Huh G, et al. The analgesic effect of decursinol. Arch Pharm Res. 2009;32:937-43 pubmed publisher
    Although decursinol, which is one of the coumarins purified from the dried roots of Angelica gigas Nakai, was previously demonstrated to have antinociceptive effects on various mouse pain models such as tail-flick, hot-plate, formalin, ..
  20. Wang K, Cao P, Wang H, Tang Z, Wang N, Wang J, et al. Chronic administration of Angelica sinensis polysaccharide effectively improves fatty liver and glucose homeostasis in high-fat diet-fed mice. Sci Rep. 2016;6:26229 pubmed publisher
    This study aimed to investigate the therapeutic effects of Angelica sinensis polysaccharide (ASP), an active component derived from a water extract of Angelica sinensis, in high-fat diet (HFD)-fed BALB/c mice...
  21. Nam S, Lee J, Lee S, Jeong J, Kang W, Cho H. Angelica gigas Nakai extract-loaded fast-dissolving nanofiber based on poly(vinyl alcohol) and Soluplus for oral cancer therapy. Int J Pharm. 2017;526:225-234 pubmed publisher
    ..and Soluplus (SP)-based nanofiber (NF) mat was fabricated using an electrospinning method for the delivery of Angelica gigas Nakai (AGN) extract (ext) to oral cancers. AGN/SP NF (mean diameter: 75±26nm; entrapment efficiency: 84...
  22. Cho J, Kwon J, Cho Y, Kim I, Kang S. Anti-Inflammatory Effect of Angelica gigas via Heme Oxygenase (HO)-1 Expression. Nutrients. 2015;7:4862-74 pubmed publisher
    b>Angelica gigas (AG) is effective against various medical conditions such as bacterial infection, inflammation, and cancer...
  23. Li G, Wang L, Shen L. [The role of angelica injection on P-selectin and anti-cardiolipin antibodies in acute pulmonary embolism rats]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2010;26:498-501 pubmed
    To study the effect of Chinese medicine, Angelica, injection on the expression of P-, E-selectin and anti-cardiolipin antibody in acute pulmonary embolism rats...
  24. Fan G, Deng R, Zhou L, Meng X, Kuang T, Lai X, et al. Development of a rapid resolution liquid chromatographic method combined with chemometrics for quality control of Angelicae dahuricae radix. Phytochem Anal. 2012;23:299-307 pubmed publisher
  25. Lee S, Choi H, Kim H, Lee H, Sung Y, Kim S, et al. Inhibitory effect of Angelicae Tenuissimae Radix on expressions of cyclooxygenase-2 and inducible nitric oxide synthase in mouse BV2 microglial cells. Neurol Res. 2010;32 Suppl 1:58-63 pubmed publisher
    ..The present study indicates that Angelicae Tenuissimae Radix can be applied as a valuable treatment for brain inflammation and headache. ..
  26. Liang X, Liao Z, Wang G, Zhao G, Dai C, Zhang X. [Influence of combination of extractum Angelicae Dahuricae Siccum and total alkaloids of Rhizoma Corydalis on pharmacokinetics of tetrahydropalmatine in rats]. Yao Xue Xue Bao. 2009;44:645-50 pubmed
    ..Coumarin and/or VO combined with TA can prolong the resistance time of TET significantly, delay elimination and enhance bioavailability of tetrahydropalmatine. ..
  27. Li Y, Yang S, Bai S. [Studies on chemical constituents from roots of Angelica polymorpha]. Zhongguo Zhong Yao Za Zhi. 2009;34:854-7 pubmed
    To investigate the chemical constituents of the roots of Angelica polymorpha. Silica gel column chromatography was employed for the isolation and purification of chemical constituents...
  28. Wang K, Yao L, Du Y, Xie J, Huang J, Yin Z. Anthelmintic activity of the crude extracts, fractions, and osthole from Radix angelicae pubescentis against Dactylogyrus intermedius in goldfish (Carassius auratus) in vivo. Parasitol Res. 2011;108:195-200 pubmed publisher
    ..2 mg/L. This is the first report on the isolation and identification of anthelmintic active compound from R. angelicae pubescentis against D. intermedius in goldfish (C. auratus) in vivo. ..
  29. Aoki N, Muko M, Ohta E, Ohta S. C-geranylated chalcones from the stems of Angelica keiskei with superoxide-scavenging activity. J Nat Prod. 2008;71:1308-10 pubmed publisher
    An ethyl acetate-soluble fraction of a methanol extract from the stems of Angelica keiskei was subjected to chromatographic separation to give three new chalcones, designated as xanthokeismins A-C (1-3), in addition to a known chalcone, ..
  30. Zhang L, Wei W, Yang X. Simultaneous Quantification of Nine New Furanocoumarins in Angelicae Dahuricae Radix Using Ultra-Fast Liquid Chromatography with Tandem Mass Spectrometry. Molecules. 2017;22: pubmed publisher
    ..long-chain hydrophobic groups, namely andafocoumarins A-H and J, have been isolated from the dried roots of Angelica dahurica cv...
  31. Liu C, Wang P, Chen Z, Wang D. [Study on molecular evidence of revision of taxonomic placement of Peucedanum decursivum]. Zhongguo Zhong Yao Za Zhi. 2006;31:1488-90 pubmed
    ..The ITS sequences and phylogenetic tree of 5 species of Angelica were and Peucedanum were acquired, in which 5 species were divided into 2 groups, Angelica group and Peucedanum ..
  32. Li R, Zhao C, Yao M, Song Y, Wu Y, Wen A. Analgesic effect of coumarins from Radix angelicae pubescentis is mediated by inflammatory factors and TRPV1 in a spared nerve injury model of neuropathic pain. J Ethnopharmacol. 2017;195:81-88 pubmed publisher
    ..from Radix angelicae pubescentis (CRAP) are a major active component that are isolated from dried roots of Angelica biserrata Yuan et Shan, which has been used clinically to cure headaches for a long period of time, and it is an ..
  33. Jang J, Lee K, Ko S. Angelica acutiloba Kitagawa Extract Attenuates DSS-Induced Murine Colitis. Mediators Inflamm. 2016;2016:9275083 pubmed publisher
    We examined the protective effects of Angelica acutiloba Kitagawa (AAK) extract on a murine model of acute experimental colitis...
  34. Woo Y, Kim H, Ze K, Chung H. Near-infrared (NIR) spectroscopy for the non-destructive and fast determination of geographical origin of Angelicae gigantis Radix. J Pharm Biomed Anal. 2005;36:955-9 pubmed
    ..With the use of the SIMCA model, independent sample datasets collected at two different periods were predicted. The Korean and Chinese samples were clearly identified with 100% accuracy. ..
  35. Zheng Y, Shen J, Wang Y, Lu A, Ho W. Anti-oxidant and anti-cancer activities of Angelica dahurica extract via induction of apoptosis in colon cancer cells. Phytomedicine. 2016;23:1267-74 pubmed publisher
    b>Angelica dahurica Radix is the common herbal medicine with anti-cancer activities. However, details of its anti-cancer activities are lacking...
  36. Sumiyoshi M, Taniguchi M, Baba K, Kimura Y. Antitumor and antimetastatic actions of xanthoangelol and 4-hydroxyderricin isolated from Angelica keiskei roots through the inhibited activation and differentiation of M2 macrophages. Phytomedicine. 2015;22:759-67 pubmed publisher
  37. Yang W, Song Y, Zhu Z, Su C, Zhang X, Wang J, et al. Anti-inflammatory dimeric furanocoumarins from the roots of Angelica dahurica. Fitoterapia. 2015;105:187-93 pubmed publisher
    Seven new dimeric furanocoumarins, dahuribiethrins A-G (1-7), were isolated from the roots of Angelica dahurica...
  38. Yoo H, Lee M, Kim Y, Yun C, Kim D. Mechanism-based inactivation of cytochrome P450 2A6 by decursinol angelate isolated from Angelica Gigas. Drug Metab Dispos. 2007;35:1759-65 pubmed
    The inhibition of CYP2A6 by decursinol angelate, a pyranocoumarin isolated from Angelica gigas roots, was examined in human liver microsomes and recombinant CYP2A6...
  39. Tsai T, Li C, Livneh H, Lin I, Lu M, Yeh C. Decreased risk of stroke in patients receiving traditional Chinese medicine for vertigo: A population-based cohort study. J Ethnopharmacol. 2016;184:138-43 pubmed publisher
    ..49-0.56). Commonly used TCM formulae, including Ban-Xia-Bai-Zhu-Tian-Ma-Tang, Ling-Gui-Zhu-Gan-Tang, Bai Zhi (Angelica dahurica (Hoffm.) Benth. & Hook.f. ex Franch. & Sav., root), Ge Gen (Pueraria lobata (Willd...
  40. Rhyu M, Kim J, Kim E. Radix angelica elicits both nitric oxide-dependent and calcium influx-mediated relaxation in rat aorta. J Cardiovasc Pharmacol. 2005;46:99-104 pubmed
    This study examined the vascular relaxation produced by Radix Angelica (AG; Dong Quai) and its possible mechanisms in isolated rat aortic rings precontracted with norepinephrine...
  41. Tang S, Zhang J, Wu W, Jiang P, Puppala M, Zhang Y, et al. Chemopreventive Effects of Korean Angelica versus Its Major Pyranocoumarins on Two Lineages of Transgenic Adenocarcinoma of Mouse Prostate Carcinogenesis. Cancer Prev Res (Phila). 2015;8:835-44 pubmed publisher
    We showed previously that daily gavage of Angelica gigas Nakai (AGN) root ethanolic extract starting 8 weeks of age inhibited growth of prostate epithelium and neuroendocrine carcinomas (NE-Ca) in the transgenic adenocarcinoma of mouse ..
  42. Wang J, Zhu L, Zou K, Cheng F, Dan F, Guo Z, et al. The anti-ulcer activities of bisabolangelone from Angelica polymorpha. J Ethnopharmacol. 2009;123:343-6 pubmed publisher
    Evaluate the anti-ulcer effects of bisabolangelone from Angelica polymorpha Maxim and provide the basic data to further study for the Angelica polymorpha and bisabolangelone...
  43. Song J, Chae J, Lee K, Lee B, Choi E, Ahn S, et al. Pharmacokinetic characterization of decursinol derived from Angelica gigas Nakai in rats. Xenobiotica. 2011;41:895-902 pubmed publisher
    Decursinol is a major coumarin derived from the roots of Angelica gigas and has various pharmacological effects against inflammation, angiogenesis, nociceptive pain and Alzheimer's disease...
  44. Wang S, Wu Y, He L, Zheng Q, Lu Y. [Identification of Chinese medicinal material radix Angelicae sinensis by X-ray diffraction Fourier fingerprint pattern method]. Zhong Yao Cai. 2003;26:709-11 pubmed
    ..The standard X-ray diffraction Fourier pattern and characteristic diffraction peaks of Radix Angelicae Sinensis were obtained. This method can be used for identification of Chinese medicinal material Radix Angelicae Sinensis. ..
  45. Kim B, Kwon Y, Lee S, Lee K, Ham I, Choi H. Vasorelaxant effects of Angelica decursiva root on isolated rat aortic rings. BMC Complement Altern Med. 2017;17:474 pubmed publisher
    ..Therefore, we attempted to identify natural medications for treating hypertension. The 70% ethanol extract of Angelica decursiva root (ADE) shows strong vasorelaxant potential, but no studies have investigated the mechanisms ..
  46. Deng G, Yang X, Zhang Y, Xu W, Wei W, Chen T. [Chemical constituents from lipophilic parts in roots of Angelica dahurica var. formosana cv. Chuanbaizhi]. Zhongguo Zhong Yao Za Zhi. 2015;40:2148-56 pubmed
    The chemical constituents from lipophilic parts in the roots of Angelica dahurica var. formosana cv. Chuanbaizhi were studied in this paper...
  47. Cui Q, Zhang J, Zhang L, Li R, Liu H. Angelica injection improves functional recovery and motoneuron maintenance with increased expression of brain derived neurotrophic factor and nerve growth factor. Curr Neurovasc Res. 2009;6:117-23 pubmed
    This study assessed the neuroprotective effects of angelica injection in the rat sciatic nerve crush injury (SCI)...
  48. Park H, Kim B, Oh J, Kim Y, Lee Y. First-pass metabolism of decursin, a bioactive compound of Angelica gigas, in rats. Planta Med. 2012;78:909-13 pubmed publisher
    Decursin is considered the major bioactive compound of Angelica gigas roots, a popular Oriental herb and dietary supplement...
  49. Yang Y, Zhang L, Zhang Y, Yang X. Simultaneous assessment of absorption characteristics of coumarins from Angelicae Pubescentis Radix: In vitro transport across Caco-2 cell and in vivo pharmacokinetics in rats after oral administration. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1060:308-315 pubmed publisher
    ..The results provided valuable information for the overall absorption characteristics of the coumarins from APR, as well as for its further studies of in vivo active substances in the further. ..
  50. Sowndhararajan K, Seo M, Kim M, Kim H, Kim S. Effect of essential oil and supercritical carbon dioxide extract from the root of Angelica gigas on human EEG activity. Complement Ther Clin Pract. 2017;28:161-168 pubmed publisher
    ..The results revealed that the EO of A. gigas root produced significant changes in the absolute low beta activity and these changes may enhance the language learning abilities of human brain. ..
  51. Gong A, Huang V, Wang H, Lin H, Dong T, Tsim K. Ferulic Acid Orchestrates Anti-Oxidative Properties of Danggui Buxue Tang, an Ancient Herbal Decoction: Elucidation by Chemical Knock-Out Approach. PLoS ONE. 2016;11:e0165486 pubmed publisher
    Ferulic acid, a phenolic acid derived mainly from a Chinese herb Angelica Sinensis Radix (ASR), was reported to reduce the formation of free radicals...
  52. Lee J, Nam S, Park J, Lee S, Jeong J, Lee J, et al. Nanocomposites based on Soluplus and Angelica gigas Nakai extract fabricated by an electrohydrodynamic method for oral administration. J Colloid Interface Sci. 2016;484:146-154 pubmed publisher
    ..NCs) based on Soluplus (SP) were fabricated by an electrohydrodynamic (EHD) method for the oral delivery of Angelica gigas Nakai (AGN)...
  53. Zhao Z, Liu H, Sun X, Guo T, Shen L, Tao Y, et al. Levistilide A inhibits angiogenesis in liver fibrosis via vascular endothelial growth factor signaling pathway. Exp Biol Med (Maywood). 2017;242:974-985 pubmed publisher
    Levistilide A (C24H28O4, molecular weight?=?380.48) derived from Angelica sinensis (Danggui) has been reported to inhibit hepatic stellate cell proliferation...