ammi

Summary

Summary: A plant genus of the family APIACEAE that is the primary plant source of KHELLIN.

Top Publications

  1. Lukacin R, Matern U, Specker S, Vogt T. Cations modulate the substrate specificity of bifunctional class I O-methyltransferase from Ammi majus. FEBS Lett. 2004;577:367-70 pubmed
    Caffeoyl-coenzyme A O-methyltransferase cDNA was cloned from dark-grown Ammi majus L. (Apiaceae) cells treated with a crude fungal elicitor and the open reading frame was expressed in Escherichia coli. The translated polypeptide of 27...
  2. Vanachayangkul P, Byer K, Khan S, Butterweck V. An aqueous extract of Ammi visnaga fruits and its constituents khellin and visnagin prevent cell damage caused by oxalate in renal epithelial cells. Phytomedicine. 2010;17:653-8 pubmed publisher
    Teas prepared from the fruits of Ammi visnaga L. (syn. "Khella") have been traditionally used in Egypt as a remedy to treat kidney stones...
  3. Jaradat N, Zaid A, Al Ramahi R, Alqub M, Hussein F, Hamdan Z, et al. Ethnopharmacological survey of medicinal plants practiced by traditional healers and herbalists for treatment of some urological diseases in the West Bank/Palestine. BMC Complement Altern Med. 2017;17:255 pubmed publisher
    ..vulgare were the most commonly used plant species in the treatment of kidney stones, while Capsella bursa-pastoris, Ammi visnaga and Ammi majus were the most recommended species for treatment of urinary tract infections and Portulaca ..
  4. Shruthi R, Venkatesh Y, Muralikrishna G. Structural and functional characterization of a novel immunomodulatory glycoprotein isolated from ajowan (Trachyspermum ammi L.). Glycoconj J. 2017;34:499-514 pubmed publisher
    Ajowan (Trachyspermum ammi L.) spice has been used in food preparations and also as a traditional medicine in Ayurveda...
  5. Günaydin K, Beyazit N. The chemical investigations on the ripe fruits of Ammi visnaga (Lam.) Lamarck growing in Turkey. Nat Prod Res. 2004;18:169-75 pubmed
    Two furanochromones and one furanochromone glycoside were isolated from the fruits of Ammi visnaga (L.) Lam. They were identified as khellin, visnagin, and khellol glycoside by interpretation of spectral analyses...
  6. Bartnik M, Sławińska Brych A, Żurek A, Kandefer Szerszen M, Zdzisinska B. 8-methoxypsoralen reduces AKT phosphorylation, induces intrinsic and extrinsic apoptotic pathways, and suppresses cell growth of SK-N-AS neuroblastoma and SW620 metastatic colon cancer cells. J Ethnopharmacol. 2017;207:19-29 pubmed publisher
    8-methoxypsoralen (8-MOP) is a furanocoumarin and an active compound of a traditional Egyptian medicinal plant Ammi majus L, whose juice/fruit has been used for many years in folk phototherapy for the treatment of vitiligo or a ..
  7. Khan Z, Assiri A, Al Afghani H, Maghrabi T. Inhibition of oxalate nephrolithiasis with Ammi visnaga (AI-Khillah). Int Urol Nephrol. 2001;33:605-8 pubmed
    We investigated the effect of Ammi visnaga seeds on experimentally - induced kidney stones - in male Wistar albino rats...
  8. Soni K, Parle M. Trachyspermum ammi Seeds Supplementation Helps Reverse Scopolamine, Alprazolam and Electroshock Induced Amnesia. Neurochem Res. 2017;42:1333-1344 pubmed publisher
    ..present study was designed to explore the beneficial effects of successive 10 days administration of Trachyspermum ammi seed's powder (TASP) along with diet (at the dose of 0.5%, 1.0% and 2.0% w/w) on learning and memory of mice...
  9. Günaydin K, Erim F. Determination of khellin and visnagin in Ammi visnaga fruits by capillary electrophoresis. J Chromatogr A. 2002;954:291-4 pubmed
    ..and quantitative determination of two medically active constituents-khellin and visnagin-in the extracts of Ammi visnaga fruits...

More Information

Publications54

  1. Kachkoul R, Sqalli Houssaini T, Miyah Y, Mohim M, El Habbani R, Lahrichi A. The study of the inhibitory effect of calcium oxalate monohydrate's crystallization by two medicinal and aromatic plants: Ammi visnaga and Punica granatum. Prog Urol. 2018;28:156-165 pubmed publisher
    ..behind, this work is to study the inhibiting effect of the calcium oxalate's crystallization by the extract of the Ammi visnaga and the Punica granatum...
  2. Chatterjee S, Jain A, De S. Effect of different operating conditions in cloud point assisted extraction of thymol from Ajwain (Trachyspermum Ammi L.) seeds and recovery using solvent. J Food Sci Technol. 2017;54:4353-4361 pubmed publisher
    Cloud point assisted extraction of thymol from water extract of Ajwain (Trachyspermum Ammi L.) seeds has been reported. Effects of different operating conditions, i.e...
  3. Zhang T, Finn D, Barlow J, Walsh J. Mast cell stabilisers. Eur J Pharmacol. 2016;778:158-68 pubmed publisher
    ..of new agents has been made since the initial discovery of the mast cell stabilising properties of khellin from Ammi visnaga and the clinical approval of cromolyn sodium...
  4. Zhang Z, Hou J, Wang W. [Stability analysis of allelopathic effects of Panax notoginseng on main crops by AMMI model]. Zhongguo Zhong Yao Za Zhi. 2015;40:191-7 pubmed
    ..The additive main effects and multiplicative interaction ( AMMI) model had been used to evaluate the stability of allelopathic effects of P...
  5. Ogbonnaya F, Rasheed A, Okechukwu E, Jighly A, Makdis F, Wuletaw T, et al. Genome-wide association study for agronomic and physiological traits in spring wheat evaluated in a range of heat prone environments. Theor Appl Genet. 2017;130:1819-1835 pubmed publisher
    ..Top 20 high-yielding genotypes, ranked by additive main effects and multiplicative interaction (AMMI), had low kinship relationship and possessed 4-5 favorable alleles for GY MTAs except two genotypes, Shadi-4 and ..
  6. Larbat R, Kellner S, Specker S, Hehn A, Gontier E, Hans J, et al. Molecular cloning and functional characterization of psoralen synthase, the first committed monooxygenase of furanocoumarin biosynthesis. J Biol Chem. 2007;282:542-54 pubmed
    b>Ammi majus L. accumulates linear furanocoumarins by cytochrome P450 (CYP)-dependent conversion of 6-prenylumbelliferone via (+)-marmesin to psoralen. Relevant activities, i.e...
  7. Parast B, Chetri S, Sharma K, Agrawal V. In vitro isolation, elicitation of psoralen in callus cultures of Psoralea corylifolia and cloning of psoralen synthase gene. Plant Physiol Biochem. 2011;49:1138-46 pubmed publisher
    ..of psoralen synthase revealed that its nucleotide sequence showed 93% homology with psoralen synthase isolated from Ammi majus...
  8. Torga P, Melo P, Pereira H, Faria L, Melo L. Genetic potential of black bean genotypes with predictable behaviors in multienvironment trials. Genet Mol Res. 2016;15: pubmed publisher
    ..of common black bean genotypes for the Central and Center-South regions of Brazil by using the Annicchiarico and AMMI (weighted average of absolute scores: WAAS, and weighted average of absolute scores and productivity: WAASP) ..
  9. Mohammed M, El Sharkawy E. Cytotoxic new furoquinoline alkaloid isolated from Ammi majus L. growing in Egypt. Nat Prod Res. 2017;31:645-652 pubmed publisher
    Two alkaloids of the furoquinoline-type were isolated from Ammi majus L...
  10. Maataoui A, Talouizte A, Benbella M, Bouhache M. [Chemical herbicidal treatment of turnips (Brassica napus L.) in Morocco]. Commun Agric Appl Biol Sci. 2003;68:425-32 pubmed
  11. Nouri L, Bendjama Z, Hamitouche A, Boumaza S, Kaouah F, Trari M, et al. Optimization of a novel biocomposite synthesis (Ammi Visnaga extraction waste/alginate) for Cd(2+) biosorption. Int J Biol Macromol. 2015;80:588-95 pubmed publisher
    A novel environmentally friendly biocomposite namely calcium alginate immobilized Ammi Visnaga (Khella) extraction waste was prepared by electrostatic extrusion method...
  12. Bucio T, Khokhar A, Mashanovich G, Gardes F. Athermal silicon nitride angled MMI wavelength division (de)multiplexers for the near-infrared. Opt Express. 2017;25:27310-27320 pubmed publisher
    ..SiNx layers to fabricate athermal (de)multiplexers based on angled multimode interferometers (AMMI) in order to achieve good spectral responses with high tolerance to dimensional errors...
  13. Nirumand M, Hajialyani M, Rahimi R, Farzaei M, Zingue S, Nabavi S, et al. Dietary Plants for the Prevention and Management of Kidney Stones: Preclinical and Clinical Evidence and Molecular Mechanisms. Int J Mol Sci. 2018;19: pubmed publisher
    ..yellow-fruit nightshade), Urtica dioica (stinging nettle), Dolichos biflorus (horse gram), Ammi visnaga (khella), Nigella sativa (black-cumin), Hibiscus sabdariffa (roselle), and Origanum ..
  14. Ibrahim I, ElBadwi S, Abdel Gadir W, Bakhiet A, Yagoub S, Adam S. Susceptibility of Bovans chicks to low dietary levels of Ammi visnaga and Artemisia herba-alba. Vet Hum Toxicol. 2004;46:67-9 pubmed
    b>Ammi visnaga seeds and Artemisia herba-alba shoots were fed to 7-d-old Bovans chicks at 2% and 10% of diet for 9 w...
  15. Bartnik M, Mazurek A. Isolation of Methoxyfuranocoumarins From Ammi majus by Centrifugal Partition Chromatography. J Chromatogr Sci. 2016;54:10-6 pubmed publisher
    Pure methoxyfuranocoumarins were isolated from Ammi majus L. by use of low-pressure column chromatography (LPCC) followed by centrifugal partition chromatography (CPC). The concentrated petroleum ether extract from fruits of A...
  16. Winderl B, Schwaiger S, Ganzera M. Fast and improved separation of major coumarins in Ammi visnaga (L.) Lam. by supercritical fluid chromatography. J Sep Sci. 2016;39:4042-4048 pubmed publisher
    ..method for the determination of five major coumarins (dihydrosamidin, visnadin, samidin, khellin, and visnagin) in Ammi visnaga fruits is described...
  17. Ngahang Kamte S, Ranjbarian F, Cianfaglione K, Sut S, Dalĺ Acqua S, Bruno M, et al. Identification of highly effective antitrypanosomal compounds in essential oils from the Apiaceae family. Ecotoxicol Environ Saf. 2018;156:154-165 pubmed publisher
    ..sicula, Crithmum maritimum, Helosciadium nodiflorum, Pimpinella anisum, Heracleum sphondylium and Trachyspermum ammi) and their essential oils as a model for the identification of trypanocidal compounds to be used as alternative/..
  18. Dou C, Chen Y, Ding N, Li N, Jiang H, Zhao C, et al. Xanthotoxin prevents bone loss in ovariectomized mice through the inhibition of RANKL-induced osteoclastogenesis. Osteoporos Int. 2016;27:2335-2344 pubmed publisher
    Xanthotoxin (XAT) is extracted from the seeds of Ammi majus...
  19. Koriem K, Asaad G, Megahed H, Zahran H, Arbid M. Evaluation of the antihyperlipidemic, anti-inflammatory, analgesic, and antipyretic activities of ethanolic extract of Ammi majus seeds in albino rats and mice. Int J Toxicol. 2012;31:294-300 pubmed publisher
    Pharmacological and biochemical studies on the Ammi majus seeds L. (family Umbelliferae) grown in Egypt are limited. Furocoumarins are the major constituents in the plant seeds...
  20. Taïbi K, Del Campo A, Aguado A, Mulet J. Early establishment response of different Pinus nigra ssp. salzmanii seed sources on contrasting environments: Implications for future reforestation programs and assisted population migration. J Environ Manage. 2016;171:184-94 pubmed publisher
    ..at each site was assessed through Joint Regression and Additive Main effect and Multiplication Interaction (AMMI) models...
  21. Pavela R, Maggi F, Cianfaglione K, Bruno M, Benelli G. Larvicidal activity of essential oils of five Apiaceae taxa and some of their main constituents against Culex quinquefasciatus. Chem Biodivers. 2017;: pubmed publisher
    ..sphondylium, Heracleum sphondylium subsp. ternatum and Trachyspemum ammi, as well as their major constituents (sabinene, p-cymene, terpinolene, myristicin and thymol), against the ..
  22. Ahmad I, Fatima U, Tabassum H, Mabood A, Ahmad A, Srivastava G, et al. Evaluation of the nutrient profile of Trachyspermum ammi L. seed under the influence of nanoparticles during germination. Cell Mol Biol (Noisy-le-grand). 2017;63:7-11 pubmed publisher
    Trachyspermum ammi L. commonly known as Ajwain is an annual herb belonging to the family Apiaceae. It is enormously grown in Egypt, Iran, Pakistan, Afghanistan, and India as well as European region...
  23. Meiouet F, El Kabbaj S, Daudon M. [In vitro study of the litholytic effects of herbal extracts on cystine urinary calculi]. Prog Urol. 2011;21:40-7 pubmed publisher
    ..In Morocco, various plants, Herniaria hirsuta, Opuntia ficus-indica, Zea mays and Ammi visnaga are proposed against nephrolithiasis...
  24. Moreira Ascarrunz S, Larsson H, Prieto Linde M, Johansson E. Mineral Nutritional Yield and Nutrient Density of Locally Adapted Wheat Genotypes under Organic Production. Foods. 2016;5: pubmed publisher
    ..each genotype and they were evaluated for stability using the Additive Main effects and Multiplicative Interaction (AMMI) stability analysis and for genotypic value, stability, and adaptability using the Best Linear Unbiased Prediction (..
  25. Hübner S, Hehmann M, Schreiner S, Martens S, Lukacin R, Matern U. Functional expression of cinnamate 4-hydroxylase from Ammi majus L. Phytochemistry. 2003;64:445-52 pubmed
    Total RNA was isolated from dark-grown cell suspension cultures of Ammi majus L...
  26. Junior E, Brogin R, Godinho V, Botelho F, Tardin F, Teodoro P. Identification of soybean genotypes with high stability for the Brazilian macro-region 402 via biplot analysis. Genet Mol Res. 2017;16: pubmed publisher
    ..The objective of this study was to verify the association between the AMMI and GGE biplot methods and to select soybean genotypes that simultaneously meet high grain yield and stability to ..
  27. Lee H, Kim G, Choi W, Park I. Repellent Activity of Apiaceae Plant Essential Oils and their Constituents Against Adult German Cockroaches. J Econ Entomol. 2017;110:552-557 pubmed publisher
    ..to find new natural repellents. Of all the plant essential oils tested, ajowan (Trachyspermum ammi Sprague) and dill (Anethum graveolens L...
  28. Sellami H, Napolitano A, Masullo M, Smiti S, Piacente S, Pizza C. Influence of growing conditions on metabolite profile of Ammi visnaga umbels with special reference to bioactive furanochromones and pyranocoumarins. Phytochemistry. 2013;95:197-206 pubmed publisher
    The medicinal plant Ammi visnaga is a valuable source of furanochromones and pyranocoumarins used as vasodilator agents...
  29. Huang M, Cabrera A, Hoffstetter A, Griffey C, Van Sanford D, Costa J, et al. Genomic selection for wheat traits and trait stability. Theor Appl Genet. 2016;129:1697-710 pubmed publisher
    ..Additive main effect and multiplicative interaction (AMMI) model and  Eberhart and Russell regression (ERR) were used to estimate trait stability...
  30. Hehmann M, Lukacin R, Ekiert H, Matern U. Furanocoumarin biosynthesis in Ammi majus L. Cloning of bergaptol O-methyltransferase. Eur J Biochem. 2004;271:932-40 pubmed
    ..bergapten and xanthotoxol to xanthotoxin, from induced cell cultures of Ruta graveolens, Petroselinum crispum and Ammi majus. Bergaptol 5-O-methyltransferase (BMT) cDNA was cloned from dark-grown Ammi majus L...
  31. Costa A, Teodoro P, Bhering L, Leal N, Tardin F, Daher R. Biplot analysis of strawberry genotypes recommended for the State of Espírito Santo. Genet Mol Res. 2016;15: pubmed publisher
    ..The aim of this study was to use AMMI (additive main effects and multiplicative interaction) and GGE biplot (genotype main effects + genotype x ..
  32. Lee J, Jung J, Park S, Park S, Sim Y, Kim S, et al. Anti-inflammatory effect of visnagin in lipopolysaccharide-stimulated BV-2 microglial cells. Arch Pharm Res. 2010;33:1843-50 pubmed publisher
    Visnagin, which is found in Ammi visnaga, has biological activity as a vasodilator and reduces blood pressure by inhibiting calcium influx into the cell...
  33. Basu S, Ghosh M, Bhunia R, Ganguly J, Banik B. Polysaccharides from Dolichos biflorus Linn and Trachyspermum ammi Linn seeds: isolation, characterization and remarkable antimicrobial activity. Chem Cent J. 2017;11:118 pubmed publisher
    ..Despite an easy availability of Dolichos biflorus Linn and Trachyspermum ammi (Linn) seeds isolation, characterization and antimicrobial studies of polysaccharides derived from these two ..
  34. Nguyen T, Aparicio M, Saleh M. Accurate Mass GC/LC-Quadrupole Time of Flight Mass Spectrometry Analysis of Fatty Acids and Triacylglycerols of Spicy Fruits from the Apiaceae Family. Molecules. 2015;20:21421-32 pubmed publisher
    ..Pimpinella anisum), carrot (Daucus carota), celery (Apium graveolens), fennel (Foeniculum vulgare), and Khella (Ammi visnaga), all from the Apiaceae family, were extracted at room temperature in chloroform/methanol (2:1 v/v) using ..
  35. Haug K, Weber B, Hochhaus G, Butterweck V. Pharmacokinetic evaluation of visnagin and Ammi visnaga aqueous extract after oral administration in rats. Planta Med. 2012;78:1831-6 pubmed publisher
    The furanochromone visnagin is one of the main compounds of Ammi visnaga L. (syn. Khella) with potential effects on kidney stone prevention...
  36. Petramfar P, Moein M, Samani S, Tabatabaei S, Zarshenas M. Trachyspermum ammi 10 % topical cream versus placebo on neuropathic pain, a randomized, double-blind, placebo-controlled trial. Neurol Sci. 2016;37:1449-55 pubmed publisher
    ..randomized, placebo-controlled trial was conducted to assay the effectiveness of Ajwain 10 % (Trachyspermum ammi Sprague) topical cream on neuropathic pain. Intervention encompassed Ajwain 10 % and placebo creams...
  37. Singh A, Ahmad A. Antioxidant Activity of Essential Oil Extracted by SC-CO? from Seeds of Trachyspermum ammi. Medicines (Basel). 2017;4: pubmed publisher
    ..b>Methods: Therefore this study was conducted to obtain essential oil from the seeds of T. ammi by conventional and non-conventional methods...
  38. Pavela R, Vrchotova N, Triska J. Larvicidal activity of extracts from Ammi visnaga Linn. (Apiaceae) seeds against Culex quinquefasciatus Say. (Diptera: Culicidae). Exp Parasitol. 2016;165:51-7 pubmed publisher
    Efficacies of the Ammi visnaga seeds extract and a majority of substances on larval Culex quinquefasciatus mortality in various development stages including pupae were studied...
  39. Krolicka A, Staniszewska I, Malinski E, Szafranek J, Lojkowska E. Stimulation of furanochromone accumulation in callus cultures of Ammi visnaga L. by addition of elicitors. Pharmazie. 2003;58:590-2 pubmed
    ..visnaga callus. The presented work shows that biosynthesis of pharmacologically important secondary metabolites in A. visnaga cultures could be stimulated by application of elicitors. ..
  40. Vanachayangkul P, Chow N, Khan S, Butterweck V. Prevention of renal crystal deposition by an extract of Ammi visnaga L. and its constituents khellin and visnagin in hyperoxaluric rats. Urol Res. 2011;39:189-95 pubmed publisher
    In Egypt, teas prepared from the fruits of Ammi visnaga L. (syn. "Khella") are traditionally used by patients with urolithiasis...
  41. Travaini M, Sosa G, Ceccarelli E, Walter H, Cantrell C, Carrillo N, et al. Khellin and Visnagin, Furanochromones from Ammi visnaga (L.) Lam., as Potential Bioherbicides. J Agric Food Chem. 2016;64:9475-9487 pubmed publisher
    ..From a previous screening of plant extracts for their phytotoxicity, a dichloromethane extract of Ammi visnaga (L.) Lam. was selected for further study...
  42. Rasul G, Glover K, Krishnan P, Wu J, Berzonsky W, Fofana B. Genetic analyses using GGE model and a mixed linear model approach, and stability analyses using AMMI bi-plot for late-maturity alpha-amylase activity in bread wheat genotypes. Genetica. 2017;145:259-268 pubmed publisher
    ..were analysed using a GGE model with a mixed linear model approach and stability analysis was presented using an AMMI bi-plot on R software...
  43. Sellami H, Flamini G, Cioni P, Smiti S. Composition of the essential oils in various organs at different developmental stages of Ammi visnaga (L.) Lam. from Tunisia. Chem Biodivers. 2011;8:1990-2004 pubmed publisher
    ..of the essential oils isolated by hydrodistillation from various organs at different development stages of Ammi visnaga (L.) Lam. growing in Tunisia was determined by GC/MS analysis...
  44. Ribeiro N, Casagrande C, Mezzomo H, Possobom M, Steckling S, Kläsener G. Simultaneous selection in beans for stability and high agronomic performance. Genet Mol Res. 2016;15: pubmed publisher
    ..Eberhart and Russel, and Lin and Binns methods, as well as the additive main effect and multiplicative interaction (AMMI) method, were used to evaluate the stability of flowering, cycle, insertion of the first pod, and grain yield of 10 ..
  45. Shirk P, Shapiro J, Reitz S, Thomas J, Koenig R, Hay Roe M, et al. Predator-prey relationships on Apiaceae at an organic farm. Environ Entomol. 2012;41:487-96 pubmed publisher
    ..and false Queen Anne's lace, Ammi majus L. F. bispinosa was the predominant thrips observed on both flowers but colonized D...