acorus

Summary

Summary: A plant genus of the family ACORACEAE, order Arales, subclass Arecidae most notable for Acorus calamus L. root which contains asarone and has been used in TRADITIONAL MEDICINE.

Top Publications

  1. Manikandan S, Srikumar R, Jeya Parthasarathy N, Sheela Devi R. Protective effect of Acorus calamus LINN on free radical scavengers and lipid peroxidation in discrete regions of brain against noise stress exposed rat. Biol Pharm Bull. 2005;28:2327-30 pubmed
    ..The aim of this study was to evaluate the protective effect of both ethyl acetate and methanolic extract of Acorus calamus LINN against noise stress (30 d, 100 dBA/4h/d) induced changes in the rat brain...
  2. Wei G, Fang Y, Liu D, Lin S. [Study on GC-MS fingerprint analysis in rhizome of volatile oil of Acorus tatarinowii]. Zhongguo Zhong Yao Za Zhi. 2004;29:764-8 pubmed
    To establish the method of fingerprint analysis on volatile oil in rhizome of Acorus tatarinowii by GC-MS, and to study the main characteristic components. The main components of 10 samples were determined by GC-MS...
  3. Wu H, Fang Y. [Pharmacokinetics of beta-asarone in rats]. Yao Xue Xue Bao. 2004;39:836-8 pubmed
    ..The absorption, distribution and elimination of beta-asarone are very rapid, and it is easy to pass through blood brain barrier. Brain is an important organ of distributing of beta-asarone. ..
  4. Han P, Han T, Peng W, Wang X. Antidepressant-like effects of essential oil and asarone, a major essential oil component from the rhizome of Acorus tatarinowii. Pharm Biol. 2013;51:589-94 pubmed publisher
    Depression is one of the most common psychiatric diseases. Acorus tatarinowii Schott (Araceae) has shown many bioactivities in treatment of senile dementia and epilepsy...
  5. Muthuraman A, Singh N, Jaggi A. Protective effect of Acorus calamus L. in rat model of vincristine induced painful neuropathy: an evidence of anti-inflammatory and anti-oxidative activity. Food Chem Toxicol. 2011;49:2557-63 pubmed publisher
    The study investigates the protective effect of Acorus calamus L. (AC) in vincristine-induced painful neuropathy. Vincristine (75?g/kg, i.p. for 10 consecutive days) was administered to induce painful neuropathy in rats...
  6. Mehrotra S, Mishra K, Maurya R, Srimal R, Yadav V, Pandey R, et al. Anticellular and immunosuppressive properties of ethanolic extract of Acorus calamus rhizome. Int Immunopharmacol. 2003;3:53-61 pubmed
    ..We have evaluated the anticellular and immunomodulatory properties of ethanolic extract of Acorus calamus rhizome...
  7. Mukherjee P, Kumar V, Mal M, Houghton P. In vitro acetylcholinesterase inhibitory activity of the essential oil from Acorus calamus and its main constituents. Planta Med. 2007;73:283-5 pubmed
    ..vitro acetylcholinesterase (AChE) inhibitory potential of the hydroalcoholic extract and of the essential oil from Acorus calamus (AC) rhizomes and that of its major constituents were evaluated based on the Ellman's method...
  8. Shah A, Gilani A. Aqueous-methanolic extract of sweet flag (Acorus calamus) possesses cardiac depressant and endothelial-derived hyperpolarizing factor-mediated coronary vasodilator effects. J Nat Med. 2012;66:119-26 pubmed publisher
    This investigation was aimed to probe the pharmacological base of medicinal use of Acorus calamus in ischemic heart diseases...
  9. Pandit S, Mukherjee P, Ponnusankar S, Venkatesh M, Srikanth N. Metabolism mediated interaction of ?-asarone and Acorus calamus with CYP3A4 and CYP2D6. Fitoterapia. 2011;82:369-74 pubmed publisher
    The present study was aimed to investigate the possible interaction of the standardized extract of Acorus calamus (AC) with Cytochrome P450 enzyme, quantitative determination of the ?-asarone in the AC rhizome was performed by RP-HPLC ..

More Information

Publications62

  1. Shah A, Gilani A. Bronchodilatory effect of Acorus calamus (Linn.) is mediated through multiple pathways. J Ethnopharmacol. 2010;131:471-7 pubmed publisher
    This study was undertaken to provide a pharmacological basis for traditional use of Acorus calamus in airways disorders...
  2. Marecik R, Króliczak P, Czaczyk K, Białas W, Olejnik A, Cyplik P. Atrazine degradation by aerobic microorganisms isolated from the rhizosphere of sweet flag (Acorus calamus L.). Biodegradation. 2008;19:293-301 pubmed
    In presented study the capability of microorganisms isolated from the rhizosphere of sweet flag (Acorus calamus) to the atrazine degradation was assessed...
  3. Björnstad K, Helander A, Hultén P, Beck O. Bioanalytical investigation of asarone in connection with Acorus calamus oil intoxications. J Anal Toxicol. 2009;33:604-9 pubmed
    Preparations of the plant Acorus calamus (calamus or sweet flag) (A. calamus) are available via internet trade and marketed as being hallucinogenic...
  4. Belska N, Guriev A, Danilets M, Trophimova E, Uchasova E, Ligatcheva A, et al. Water-soluble polysaccharide obtained from Acorus calamus L. classically activates macrophages and stimulates Th1 response. Int Immunopharmacol. 2010;10:933-42 pubmed publisher
    A pectic polysaccharide was isolated from the rhizomes of Acorus calamus L. The main component of its carbohydrate chain was represented by residues of D-galacturonic acid (>85%)...
  5. Du Z, Clery R, Hammond C. Volatiles from leaves and rhizomes of Fragrant Acorus spp. (Acoraceae). Chem Biodivers. 2008;5:887-95 pubmed publisher
    Three horticultural selections of Acorus gramineus Soland were investigated to determine the chemical composition of their leaves and rhizomes...
  6. Geng Y, Li C, Liu J, Xing G, Zhou L, Dong M, et al. Beta-asarone improves cognitive function by suppressing neuronal apoptosis in the beta-amyloid hippocampus injection rats. Biol Pharm Bull. 2010;33:836-43 pubmed
    ..In this study, we investigated the effects of beta-asarone, the major ingredient of Acorus Tatarinowii Schott, on cognitive function and neuronal apoptosis in Abeta hippocampus injection rats and its ..
  7. Kumar R, Prakash O, Pan A, Hore S, Chanotiya C, Mathela C. Compositional variations and anthelmentic activity of essential oils from rhizomes of different wild populations of Acorus calamus L. and its major component, beta-Asarone. Nat Prod Commun. 2009;4:275-8 pubmed
    Hydro-distilled essential oils from Acorus calamus rhizomes collected from six different geographical zones in the northwest Himalayan region of Uttarakhand have been analyzed by GC and GC/MS...
  8. Gilani A, Shah A, Ahmad M, Shaheen F. Antispasmodic effect of Acorus calamus Linn. is mediated through calcium channel blockade. Phytother Res. 2006;20:1080-4 pubmed
    b>Acorus calamus Linn. (Araceae) is a native of Central Asia and Eastern Europe and has widespread use in the traditional system of medicine for gastrointestinal disorders such as colic pain and diarrhoea...
  9. Muthuraman A, Singh N, Jaggi A. Effect of hydroalcoholic extract of Acorus calamus on tibial and sural nerve transection-induced painful neuropathy in rats. J Nat Med. 2011;65:282-92 pubmed publisher
    This study was designed to investigate the therapeutic potential of hydroalcoholic extracts of Acorus calamus (AC) in tibial and sural nerve transection (TST)-induced neuropathic pain in rats...
  10. Zaugg J, Eickmeier E, Ebrahimi S, Baburin I, Hering S, Hamburger M. Positive GABA(A) receptor modulators from Acorus calamus and structural analysis of (+)-dioxosarcoguaiacol by 1D and 2D NMR and molecular modeling. J Nat Prod. 2011;74:1437-43 pubmed publisher
    In a two-microelectrode voltage clamp with Xenopus laevis oocytes, a petroleum ether extract of Acorus calamus rhizomes enhanced the GABA-induced chloride current through GABA(A) receptors of the ?????(2S) subtype by 277% ± 9...
  11. Shukla P, Khanna V, Ali M, Maurya R, Khan M, Srimal R. Neuroprotective effect of Acorus calamus against middle cerebral artery occlusion-induced ischaemia in rat. Hum Exp Toxicol. 2006;25:187-94 pubmed
    The neuroprotective potential of ethanol:water (1:1) extract of rhizomes of Acorus calamus (AC-002) has been investigated in middle cerebral artery occlusion (MCAO)-induced ischaemia in rats...
  12. Hazra R, Ray K, Guha D. Inhibitory role of Acorus calamus in ferric chloride-induced epileptogenesis in rat. Hum Exp Toxicol. 2007;26:947-53 pubmed publisher
    The roots and rhizomes of Acorus calamus (Family: Araceae) have been used in the ancient systems of medicine for the treatment of various neurological disorders...
  13. Hu G, Zhang W, Shang Y, He L. [Inhibitory effects of dry Acorus calamus extracts on the growth of two water bloom-forming algal species]. Ying Yong Sheng Tai Xue Bao. 2009;20:2277-82 pubmed
    A trial with different concentrations of aqueous extracts from dry Acorus calamus plants was conducted to study the effects of the extracts on Microcystis aeruginosa and Chlorella pyrenoidosa growth. Allelopathic effects were observed...
  14. Berg K, Bischoff R, Stegmüller S, Cartus A, Schrenk D. Comparative investigation of the mutagenicity of propenylic and allylic asarone isomers in the Ames fluctuation assay. Mutagenesis. 2016;31:443-51 pubmed publisher
    ..g. Acorus calamus is used to prepare tea...
  15. Zhang W, Feng X, Lu D, Gao H, Yu Y, Yao X. New lignans attenuating cognitive deterioration of Aβ transgenic flies discovered in Acorus tatarinowii. Bioorg Med Chem Lett. 2018;28:814-819 pubmed publisher
    ..lignan racemates, (±)-tatarinoid D-H (1-5), and three known analogues (6-8) were isolated from the rhizomes of Acorus tatarinowii. Their structures were established by 1D, 2D-NMR, HR-MS, IR and optical spectral data...
  16. Lam K, Yao P, Wang H, Duan R, Dong T, Tsim K. Asarone from Acori Tatarinowii Rhizome prevents oxidative stress-induced cell injury in cultured astrocytes: A signaling triggered by Akt activation. PLoS ONE. 2017;12:e0179077 pubmed publisher
    ..These results demonstrated that ?-asarone and ?-asarone could account, at least partly, the function of ATR being a Chinese medicinal herb. ..
  17. Zhao L, Wu J, Wu F. [A review of recent ten-year study on alpha-asarone]. Zhongguo Zhong Yao Za Zhi. 2007;32:562-5, 650 pubmed
    ..This article is brief review of study on alpha-asarone after 1996. The summary mainly includes the dosage forms, pharmacokinetics, bioavailability, pharmacological effects, toxicology and clinical uses during the past ten years. ..
  18. Goremykin V, Holland B, Hirsch Ernst K, Hellwig F. Analysis of Acorus calamus chloroplast genome and its phylogenetic implications. Mol Biol Evol. 2005;22:1813-22 pubmed
    ..improve taxon sampling in the existing chloroplast genome data, we sequenced the chloroplast genome of the monocot Acorus calamus...
  19. Sandeep D, Krishnan Nair C. Amelioration of cisplatin-induced nephrotoxicity by extracts of Hemidesmus indicus and Acorus calamus. Pharm Biol. 2010;48:290-5 pubmed publisher
    ..The extracts of medicinal plants Hemidesmus indicus L. (Apocynaceae) and Acorus calamus L. (Araceae) protected the renal tissue effectively from cisplatin-induced toxicity...
  20. Kumari R, Singh S, Agrawal S. Response of ultraviolet-B induced antioxidant defense system in a medicinal plant, Acorus calamus. J Environ Biol. 2010;31:907-11 pubmed
    ..In the present study, an important medicinal plant Acorus calamus (Sweet flag) was subjected to two doses of supplemental UV-B radiation (sUV-B): sUV1 (+ 1...
  21. Ahn S, Kim Y, Kim H, Choi Y, Lee J, Kim C, et al. Neuroprotection and spatial memory enhancement of four herbal mixture extract in HT22 hippocampal cells and a mouse model of focal cerebral ischemia. BMC Complement Altern Med. 2015;15:202 pubmed publisher
    ..Rehmannia glutinosa (Gaertn) Libosch., Polygala tenuifolia Willd., and Acorus gramineus Soland...
  22. Deng D, Liu J, Xu M, Zheng G, Guo J, Sun G. Uptake, translocation and metabolism of decabromodiphenyl ether (BDE-209) in seven aquatic plants. Chemosphere. 2016;152:360-8 pubmed publisher
    ..namely Phragmites australis, Cyperus papyrus, Alternanthera philoxeroides, Colocasia esculenta, Scirpus validus, Acorus calamus and Oryza sativa. In all seven plants, O...
  23. Zhu M, Tan N, Xiong J, Ji C, Zhu H, Xu J, et al. [Chemical constituents contained in ethanol extracts from Acorus tatarinowii and their anti-fatigue activity]. Zhongguo Zhong Yao Za Zhi. 2012;37:2898-901 pubmed
    Chemical constituents in ethyl acetate and butanol fractions of ethanol extracts from Acorus tatarinowii were separated by column chromatography...
  24. Radhakrishnan A, Jayakumari N, Kumar V, Gulia K. Sleep promoting potential of low dose ?-Asarone in rat model. Neuropharmacology. 2017;125:13-29 pubmed publisher
    ..The hypnotic potential of ?-Asarone, an active principle of Acorus species, was tested in the present study by first identifying the optimal dose of ?-Asarone for improving sleep, ..
  25. Benny B, George Priya Doss C, Thirumal Kumar D, Asha Devi S. Assessing reproductive toxicity and antioxidant enzymes on beta asarone induced male Wistar albino rats: In vivo and computational analysis. Life Sci. 2017;173:150-160 pubmed publisher
    Beta asarone is the major constituent of oil obtained from Acorus calamus, the Indian traditional medicine plant...
  26. Kim K, Kim H, Choi S, Moon E, Kim S, Lee K. Bioactive lignans from the rhizomes of Acorus gramineus. J Nat Prod. 2011;74:2187-92 pubmed publisher
    ..of our ongoing search for bioactive constituents from natural Korean sources, the investigation of rhizomes of Acorus gramineus afforded five new lignans, named ligraminols A-E (1-5), together with seven known ones (6-12)...
  27. Park C, Kim K, Lee I, Lee S, Choi S, Lee J, et al. Phenolic constituents of Acorus gramineus. Arch Pharm Res. 2011;34:1289-96 pubmed publisher
    The purification of a MeOH extract from the rhizome of Acorus gramineus (Araceae) using column chromatography furnished two new stereoisomers of phenylpropanoid, acoraminol A (1) and acoraimol B (2)...
  28. Park H, Kim J, Lee Y, Chun H, Choi Y, Shin H, et al. PMC-12, a traditional herbal medicine, enhances learning memory and hippocampal neurogenesis in mice. Neurosci Lett. 2016;617:254-63 pubmed publisher
    ..a mixture of four medicinal herbs, that is, Polygonum multiflorum, Polygala tenuifolia, Rehmannia glutinosa, and Acorus gramineus, on hippocampal neurogenesis, learning, and memory in mice...
  29. Muthuraman A, Singh N. Neuroprotective effect of saponin rich extract of Acorus calamus L. in rat model of chronic constriction injury (CCI) of sciatic nerve-induced neuropathic pain. J Ethnopharmacol. 2012;142:723-31 pubmed publisher
    Traditionally, Acorus calamus has been used for the treatment and management of headache, migraine, body ache and severe inflammatory pain in the Unani, Ayurveda and Indian system of medicine...
  30. Lee H. Fungicidal property of active component derived from Acorus gramineus rhizome against phytopathogenic fungi. Bioresour Technol. 2007;98:1324-8 pubmed
    The fungicidal property of Acorus gramineus rhizome-derived materials against Botrytis cineria, Erysiphe graminis, Phytophthora infestans, Puccinia recondita, Pyricularia grisea, and Rhizoctonia solani was tested using a whole plant ..
  31. Sinha A, Acharya R, Joshi B. A mild and convenient procedure for the conversion of toxic beta-asarone into rare phenylpropanoids: 2,4,5-trimethoxycinnamaldehyde and gamma-asarone. J Nat Prod. 2002;65:764-5 pubmed
    ..Reduction of 4 with sodium borohydride in acetic acid afforded gamma-asarone (1) in 43% yield. ..
  32. Buzgo M, Soltis D, Soltis P, Ma H. Towards a comprehensive integration of morphological and genetic studies of floral development. Trends Plant Sci. 2004;9:164-73 pubmed
    ..Taxa occupying key phylogenetic positions offer great potential for generating hypotheses about the regulation of floral development...
  33. Liang S, Ying S, Wu H, Liu Y, Dong P, Zhu Y, et al. A novel sesquiterpene and three new phenolic compounds from the rhizomes of Acorus tatarinowii Schott. Bioorg Med Chem Lett. 2015;25:4214-8 pubmed publisher
    ..together with two new amides, a new biphenylpropanoid and two known lignans were isolated from the rhizomes of Acorus tatarinowii Schott...
  34. Li J, Zhao J, Wang W, Li L, Zhang L, Zhao X, et al. New Acorane-Type Sesquiterpene from Acorus calamus L. Molecules. 2017;22: pubmed publisher
    ..acid (2) and calamusin D (3), were isolated from a 95% ethanol extract of the rhizome parts of Acorus calamus L...
  35. Qiu G, Chen S, Guo J, Wu J, Yi Y. Alpha-asarone improves striatal cholinergic function and locomotor hyperactivity in Fmr1 knockout mice. Behav Brain Res. 2016;312:212-8 pubmed publisher
    ..Alpha (?)-asarone, a major bioactive component isolated from Acorus gramineus, has been shown in previous studies to improve various disease conditions including central nervous ..
  36. Wang Q, Zhang W, Li C, Xiao B. Phytoremediation of atrazine by three emergent hydrophytes in a hydroponic system. Water Sci Technol. 2012;66:1282-8 pubmed publisher
    ..evaluate atrazine (ATZ) removal and uptake by three emergent hydrophytes, Iris pseudacorus, Lythrum salicaria and Acorus calamus, determining their potential as phytoremediation agents for ATZ-contaminated water...
  37. Prasad L, Khan T, Jahangir T, Sultana S. Acorus calamus extracts and nickel chloride: prevention of oxidative damage and hyperproliferation response in rat kidney. Biol Trace Elem Res. 2006;113:77-92 pubmed
    ..In this article, we report the effect of Acorus calamus on nickel chloride (NiCl2)-induced renal oxidative stress, toxicity, and cell proliferation response in ..
  38. Wu Z, Gao J, Chen H, Hu Y, Liang W. [Study on alpha-asarone reservoir-type patch]. Zhongguo Zhong Yao Za Zhi. 2007;32:484-7 pubmed
    ..Ethanol combined with IPM is good permeation enhancer, which facilitated the permeation of alpha K-asarone to fit the clinical requirements. However, the further studies of the skin's stimulation and bioavailability are needed. ..
  39. Sun H, Hu Y, Zhang J, Li S, He W. [Effects of one Chinese herbs on improving cognitive function and memory of Alzheimer's disease mouse models]. Zhongguo Zhong Yao Za Zhi. 2003;28:751-4 pubmed
    ..CHP II has profound curative effects on improving the memory and cognitive function of AD-like animal model. The present study indicates that it has a satisfactory prospect to seek new drugs from Chinese herbs to treat AD. ..
  40. Dang H, Sun L, Liu X, Peng B, Wang Q, Jia W, et al. Preventive action of Kai Xin San aqueous extract on depressive-like symptoms and cognition deficit induced by chronic mild stress. Exp Biol Med (Maywood). 2009;234:785-93 pubmed publisher
    ..Taken together, these results indicate that KXS exerts its antidepressant-like and nootropic effects in the CMS model by modulating the HPA axis, monoamine neurotransmitter and cholinergic systems. ..
  41. Schlüter U, Crawford R. Long-term anoxia tolerance in leaves of Acorus calamus L. and Iris pseudacorus L. J Exp Bot. 2001;52:2213-25 pubmed
    Mature green leaves of Acorus calamus and Iris pseudacorus have been shown to survive at least 28 d of total anoxia in the dark during the growing season, increasing up to 75 d and 60 d in overwintering leaves in A. calamus and I...
  42. Ilaiyaraja N, Khanum F. Amelioration of alcohol-induced hepatotoxicity and oxidative stress in rats by Acorus calamus. J Diet Suppl. 2011;8:331-45 pubmed publisher
    The protective effect of a methanolic extract (ME) of Acorus calamus against alcohol-induced hepatotoxicity and oxidative stress was studied in rats...
  43. Parki A, Chaubey P, Prakash O, Kumar R, Pant A. Seasonal Variation in Essential Oil Compositions and Antioxidant Properties of Acorus calamus L. Accessions. Medicines (Basel). 2017;4: pubmed publisher
    b>Background:Acorus calamus (Sweet flag) is a known herbal drug commonly used in traditional medicine...
  44. Lopatina K, Safonova E, Nevskaya K, Stakheeva M, Gur ev A, Zueva E, et al. Effect of Acorus calamus L. Polysaccharide on CD274 and CD326 Expression by Lewis Lung Carcinoma Cells in Mice. Bull Exp Biol Med. 2017;164:102-105 pubmed publisher
    ..The experimental preparation on the basis of ?(1,2)-L-rhamno-?(1,4)-D-galactopyranosyluronan from Acorus calamus L...
  45. Yao X, Ling Y, Guo S, He S, Wang J, Zhang Q, et al. Inhibition of dengue viral infection by diasarone-I is associated with 2'O methyltransferase of NS5. Eur J Pharmacol. 2018;821:11-20 pubmed publisher
    ..To identify novel anti-DENV compound from traditional Chinese medicine, we discovered the ethanol extract of Acorus tatarinowii Schott containing potent anti-DENV activity and diasarone-I was isolated from this extract...
  46. Jiang J, Kim J, Kim D, Kim M, Oh N, Koppula S, et al. Acorus gramineus inhibits microglia mediated neuroinflammation and prevents neurotoxicity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of Parkinson's disease. J Ethnopharmacol. 2012;144:506-13 pubmed publisher
    b>Acorus gramineus Solander (Acoraceae, AG), is a widely distributed plant in Asian countries...
  47. Huang C, Li W, Zhang X, Wang L, Xu T, Wu D, et al. ?-asarone from Acorus gramineus alleviates epilepsy by modulating A-type GABA receptors. Neuropharmacology. 2013;65:1-11 pubmed publisher
    Alpha (?)-asarone is a major effective compound isolated from the Chinese medicinal herb Acorus gramineus, which is widely used in clinical practice as an antiepileptic drug; however, its mechanism of action remains unclear...
  48. Mo Z, Fang Y, He Y, Zhang S. ?-Asarone protects PC12 cells against OGD/R-induced injury via attenuating Beclin-1-dependent autophagy. Acta Pharmacol Sin. 2012;33:737-42 pubmed publisher
    To explore the effects of ?-asarone from Acorus Tatarinowii Schott on autophagy in an ischemic stroke model of PC12 cells...
  49. Dong W, Yang D, Lu R. Chemical constituents from the rhizome of Acorus calamus L. Planta Med. 2010;76:454-7 pubmed publisher
    ..alpha,4 alpha, 10 alpha-triol ( 3), together with 25 known ones, were isolated from the rhizome of Acorus calamus L...
  50. Safonova E, Lopatina K, Vychuzhanina A, Ermolaeva L, Razina T, Zueva E. Plant Polysaccharides Attenuate Fluorouracil Toxicity for the Small Intestinal Epithelium. Bull Exp Biol Med. 2016;161:308-11 pubmed publisher
    Polysaccharides from Tussilago farfara L., Acorus calamus L., and Echinacea purpurea (L.) Moench attenuated the toxic effect of fl uorouracil on the small intestinal epithelium of mice with Lewis lung carcinoma...
  51. Gao E, Zhou Z, Zou J, Yu Y, Feng X, Chen G, et al. Bioactive Asarone-Derived Phenylpropanoids from the Rhizome of Acorus tatarinowii Schott. J Nat Prod. 2017;80:2923-2929 pubmed publisher
    ..asarone-derived lignan (12), and four known lignan analogues (11 and 13-15) were isolated from the rhizome of Acorus tatarinowii Schott...
  52. Cho J, Kim Y, Kong J, Yang C, Park C. Protection of cultured rat cortical neurons from excitotoxicity by asarone, a major essential oil component in the rhizomes of Acorus gramineus. Life Sci. 2002;71:591-9 pubmed
    ..The alpha-asarone was found to exhibit more potent inhibition of [3H]MK-801 bindings, which is consistent with its more potent neuroprotective action than the beta- or the isolated asarone. ..
  53. Koo B, Park K, Ha J, Park J, Lim J, Lee D. Inhibitory effects of the fragrance inhalation of essential oil from Acorus gramineus on central nervous system. Biol Pharm Bull. 2003;26:978-82 pubmed
    ..to evaluate central inhibitory effects of the essential oil from Acori graminei Rhizoma (AGR), the dry rhizomes of Acorus gramineus SOLANDER (Araceae) upon fragrance inhalation (aroma therapy)...