lycopodium

Summary

Summary: A plant genus of the family LYCOPODIACEAE. Members contain ALKALOIDS. Lycopodium oil is obtained from L. clavatum.

Top Publications

  1. Ma X, Gang D. The Lycopodium alkaloids. Nat Prod Rep. 2004;21:752-72 pubmed
    b>Lycopodium alkaloids are quinolizine, or pyridine and alpha-pyridone type alkaloids. Some Lycopodium alkaloids are potent inhibitors of acetylcholinesterase (AChE)...
  2. Pathak S, Kumar Das J, Jyoti Biswas S, Khuda Bukhsh A. Protective potentials of a potentized homeopathic drug, Lycopodium-30, in ameliorating azo dye induced hepatocarcinogenesis in mice. Mol Cell Biochem. 2006;285:121-31 pubmed
    The protective potentials of a potentized homeopathic drug, Lycopodium-30, prepared from extract of spores of a plant, Lyocopodium clavatum (Fam: Lycopodiaceae) and used as a remedy for various liver ailments, have been tested in mice ..
  3. Orhan I, Kupeli E, Sener B, Yesilada E. Appraisal of anti-inflammatory potential of the clubmoss, Lycopodium clavatum L. J Ethnopharmacol. 2007;109:146-50 pubmed
    ..ether, chloroform, ethyl acetate and methanol as well as the alkaloid fraction from the aerial parts of Lycopodium clavatum L...
  4. Li Y, Yin G, Wei W, Wang H, Jiang S, Zhu D, et al. Interactions of Lycopodium alkaloids with acetylcholinesterase investigated by 1H NMR relaxation rate. Biophys Chem. 2007;129:212-7 pubmed
    In order to further understand the interaction processes between the Lycopodium alkaloids and acetylcholinesterase, the binding properties of N-acetyl huperzine A (1), huperzine B (2) and huperzine F (3) with Torpediniforms Nacline ..
  5. Conti E, De Checchi G, Mencarelli R, Pinato S, Rovere P. Lycopodium similiaplex-induced acute hepatitis: a case report. Eur J Gastroenterol Hepatol. 2008;20:469-71 pubmed publisher
    ..She had taken Lycopodium similiaplex solution as sedative for the previous 8 weeks, whose two constituents, Lycopodium serratum and ..
  6. Tutar H, Yilmaz E, Pehlivan E, Yilmaz M. Immobilization of Candida rugosa lipase on sporopollenin from Lycopodium clavatum. Int J Biol Macromol. 2009;45:315-20 pubmed publisher
    Sporopollenin is a natural polymer obtained from Lycopodium clavatum, which is highly stable with constant chemical structure and has high resistant capacity to chemical attack...
  7. Mandal S, Biswas R, Bhattacharyya S, Paul S, Dutta S, Pathak S, et al. Lycopodine from Lycopodium clavatum extract inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation. Eur J Pharmacol. 2010;626:115-22 pubmed publisher
    Crude ethanolic extract of the plant Lycopodium clavatum has long been used in complementary and alternative medicine for treating various liver ailments and Alzheimer's disease...
  8. Hirasawa Y, Morita H, Kobayashi J. Nankakurine A, a novel C16N2-type alkaloid from Lycopodium hamiltonii. Org Lett. 2004;6:3389-91 pubmed
    sstructure: see text] A novel, fused-tetracyclic Lycopodium alkaloid, nankakurine A (1), consisting of a cyclohexane ring and a 3-aza-bicyclo[3.3...
  9. Cheng J, Liu F, Li X, Wu X, Dong L, Peng L, et al. Lycospidine A, a new type of Lycopodium alkaloid from Lycopodium complanatum. Org Lett. 2013;15:2438-41 pubmed publisher
    Lycospidine A (1), the first example of a Lycopodium alkaloid which contains an unprecedented five-membered A ring, was isolated from Lycopodium complanatum...

More Information

Publications120 found, 100 shown here

  1. Bradshaw B, Luque Corredera C, Bonjoch J. cis-Decahydroquinolines via asymmetric organocatalysis: application to the total synthesis of lycoposerramine Z. Org Lett. 2013;15:326-9 pubmed publisher
    A concise synthesis of the Lycopodium alkaloid lycoposerramine Z is reported...
  2. Hanif K, Kumar M, Singh N, Shukla R. Effect of homeopathic Lycopodium clavatum on memory functions and cerebral blood flow in memory-impaired rats. Homeopathy. 2015;104:24-8 pubmed publisher
    b>Lycopodium clavatum (Lyc) is a widely used homeopathic medicine for the liver, urinary and digestive disorders...
  3. Morresi Hauf A, Neher A, Wöckel W, Kammler Baumann H. [Granulomatous bronchiolitis due to aspiration of lycopodium spores by fire-breathing]. Pneumologie. 2009;63:67-71 pubmed publisher
    ..The patient had aspirated Lycopodium spores in the course of occasional fire-breathing...
  4. Okubo T, Kokufuta E, Nakamuro M, Yoshinaga K, Mizutani M, Tsuchida A. Drying dissipative structures of lycopodium spore particles in aqueous dispersion. Colloids Surf B Biointerfaces. 2010;80:193-9 pubmed publisher
    Drying dissipative structures of aqueous dispersions of lycopodium particles (31 microm in average diameter) from the spores of Lycopodium clavatum were studied as a function of the particle concentrations in the presence and the absence ..
  5. Zhang G, Wang F, Du J, Qu H, Ma X, Wei M, et al. Toward the total synthesis of palhinine A: expedient assembly of multifunctionalized isotwistane ring system with contiguous quaternary stereocenters. Org Lett. 2012;14:3696-9 pubmed publisher
    ..3.1.0(3,7)]decane) system, 5/6/6 ring, with contiguous quaternary stereocenters in Lycopodium alkaloid palhinine A and its analogues via an intramolecular Diels-Alder strategy is described.
  6. Liu Y, Su J, Wu X, Zhang Z, Fan M, Zhu Q, et al. Five new Lycopodium alkaloids from the aerial parts of Phlegmariurus henryi. Fitoterapia. 2016;115:148-154 pubmed publisher
    A series of new Lycopodium alkaloids, namely 1-epi-malycorin A (1), 1-epi-17S-hydroxymalycorin A (2), 6?-hydroxyphlegmariurine A (3), 2S,4R-dihydroxyfawcettimine (4), and 16-hydroxylycodine (5), together with 24 known ones, have been ..
  7. Pereira A, Góis M, Lera K, Falkowski Temporini G, Massini P, Drozino R, et al. Histopathological lesions in encephalon and heart of mice infected with Toxoplasma gondii increase after Lycopodium clavatum 200dH treatment. Pathol Res Pract. 2017;213:50-57 pubmed publisher
    ..three more times), when compared with IC (infected and non-treated), suggests protective effect exerted by Lycopodium clavatum. If on the one hand L...
  8. Kozak J, Dake G. Total synthesis of (+)-fawcettidine. Angew Chem Int Ed Engl. 2008;47:4221-3 pubmed publisher
  9. Winther J, Friedman W. Phylogenetic affinity of arbuscular mycorrhizal symbionts in Psilotum nudum. J Plant Res. 2009;122:485-96 pubmed publisher
    ..nudum greenhouse populations have the potential to be exploited as an experimental system to further study the physiology, ecology and evolution of mycoheterotrophic AM associations. ..
  10. Kogure N, Maruyama M, Wongseripipatana S, Kitajima M, Takayama H. New Lycopodine-Type Alkaloids from Lycopodium carinatum. Chem Pharm Bull (Tokyo). 2016;64:793-9 pubmed publisher
    The structures of new lycopodine-type alkaloids, lycopocarinamines A-F, which were isolated from Lycopodium carinatum, were elucidated by spectroscopic analysis and chemical conversions...
  11. Dong L, Gao X, Liu F, He J, Wu X, Li Y, et al. Isopalhinine A, a unique pentacyclic Lycopodium alkaloid from Palhinhaea cernua. Org Lett. 2013;15:3570-3 pubmed publisher
    A new pentacyclic (5/6/6/6/7) Lycopodium alkaloid named isopalhinine A (1), which possesses a sterically congested architecture built with a tricyclo[4.3.1.0(3,7)]decane (isotwistane) moiety and a 1-azabicyclo[4.3...
  12. Eizayaga J, Pozzi M, Canan M, Saravia L. Prevalence and likelihood ratio of symptoms in patients with good therapeutic response to Lycopodium clavatum. A retrospective study. Homeopathy. 2016;105:78-83 pubmed publisher
    ..To investigate the prevalence and LR of symptoms commonly attributed to the homeopathic medicine Lycopodium clavatum (Lyc)...
  13. Wyss E, Tamm L, Siebenwirth J, Baumgartner S. Homeopathic preparations to control the rosy apple aphid (Dysaphis plantaginea Pass.). ScientificWorldJournal. 2010;10:38-48 pubmed publisher
    ..The assessment included the substance Lycopodium clavatum and a nosode of the rosy apple aphid...
  14. Winther J, Friedman W. Arbuscular mycorrhizal associations in Lycopodiaceae. New Phytol. 2008;177:790-801 pubmed
    ..and phylogenetic identity of fungi involved in arbuscular mycorrhizal (AM) associations in extant Huperzia and Lycopodium (Lycopodiaceae)...
  15. Kitsunezaki S, Sasaki A, Nishimoto A, Mizuguchi T, Matsuo Y, Nakahara A. Memory effect and anisotropy of particle arrangements in granular paste. Eur Phys J E Soft Matter. 2017;40:88 pubmed publisher
    ..work, we find a similar behavior in pastes consisting of large granular particles, specifically cornstarch and Lycopodium spores...
  16. Xu B, Lei L, Zhu X, Zhou Y, Xiao Y. Identification and characterization of L-lysine decarboxylase from Huperzia serrata and its role in the metabolic pathway of lycopodium alkaloid. Phytochemistry. 2017;136:23-30 pubmed publisher
  17. Teranishi H, Uchida M, Hayashi S, Yamada N. Allergenic pollens and spores in the working environment of Japanese pear farmers. Int J Immunopathol Pharmacol. 2007;20:65-7 pubmed
    ..These results suggest that the exposure to allergenic pollens and spores induces allergic symptoms. Thus, caution should be paid for the avoidance of the exposure to these allergenic pollens and spores to prevent the allergy. ..
  18. Ishida H, Kimura S, Kogure N, Kitajima M, Takayama H. The first asymmetric total synthesis of lycoposerramine-R. Org Biomol Chem. 2015;13:7762-71 pubmed publisher
    The first asymmetric total synthesis of lycoposerramine-R, a Lycopodium alkaloid possessing a novel skeleton, was accomplished by a strategy featuring the stereoselective intramolecular aldol cyclization giving a cis-fused 5/6 bicyclic ..
  19. Bunsupa S, Hanada K, Maruyama A, Aoyagi K, Komatsu K, Ueno H, et al. Molecular Evolution and Functional Characterization of a Bifunctional Decarboxylase Involved in Lycopodium Alkaloid Biosynthesis. Plant Physiol. 2016;171:2432-44 pubmed publisher
    b>Lycopodium alkaloids (LAs) are derived from lysine (Lys) and are found mainly in Huperziaceae and Lycopodiaceae. LAs are potentially useful against Alzheimer's disease, schizophrenia, and myasthenia gravis...
  20. Yang M, You W, Wu S, Fan Z, Xu B, Zhu M, et al. Global transcriptome analysis of Huperzia serrata and identification of critical genes involved in the biosynthesis of huperzine A. BMC Genomics. 2017;18:245 pubmed publisher
    ..serrata produces various types of effectively bioactive lycopodium alkaloids, especially the huperzine A (HupA) which is a promising drug for Alzheimer's disease...
  21. Nishikawa Y, Kitajima M, Takayama H. First asymmetric total syntheses of cernuane-type Lycopodium alkaloids, cernuine, and cermizine D. Org Lett. 2008;10:1987-90 pubmed publisher
    The first total syntheses of two cernuane-type Lycopodium alkaloids, (-)-cernuine and (+)-cermizine D, were accomplished starting from (+)-citronellal...
  22. de Souza M, Costa e Silva E, Macedo G, Soares B, Zúccari C. The effect of individualized homeopathic treatment on the semen quality of bulls with reproductive disorders: a case series. Homeopathy. 2012;101:243-5 pubmed publisher
    ..The bulls were treated with Sulphur, Phosphorus, Lycopodium and Argentum nitricum all in 30CH dilution. The rates of successful collection were 97.14%, 100%, 96.67% and 30...
  23. Falkowski Temporini G, Lopes C, Massini P, Brustolin C, Sandri P, Ferreira Ã, et al. Predominance of Th1 response, increase of megakaryocytes and Kupffer cells are related to survival in Trypanosoma cruzi infected mice treated with Lycopodium clavatum. Cytokine. 2016;88:57-61 pubmed publisher
    ..Th1/Th2 and Th1/Th17 cytokines in survival of mice infected with Y strain of Trypanosoma cruzi and treated with Lycopodium clavatum...
  24. Bartels D, Classen B. Structural investigations on arabinogalactan-proteins from a lycophyte and different monilophytes (ferns) in the evolutionary context. Carbohydr Polym. 2017;172:342-351 pubmed publisher
    ..However, it was higher for Lycopodium AGP (17%)...
  25. Li H, Lei X. Fawcettimine-Type Lycopodium Alkaloids as a Driving Force for Discoveries in Organic Synthesis. Chem Rec. 2017;: pubmed publisher
    ..since the pioneering synthetic work reported by both Inubushi and Heathcock back in 1980s, the fawcettimine-type Lycopodium alkaloids have continuously served as a driving force for discoveries in organic synthesis...
  26. Nakayama A, Kogure N, Kitajima M, Takayama H. Asymmetric total synthesis of a pentacyclic Lycopodium alkaloid: huperzine-Q. Angew Chem Int Ed Engl. 2011;50:8025-8 pubmed publisher
    ..4 % overall yield. This synthesis involved a novel stereoselective Pauson-Khand reaction, a vinyl Claisen rearrangement, and a biomimetic spiroaminal formation. TBDPS=tert-butyldiphenylsilyl. ..
  27. Wolfe J, Exline D. Characterization of condom lubricant components using Raman spectroscopy and Raman chemical imaging. J Forensic Sci. 2003;48:1065-74 pubmed
    ..This preliminary investigation provides a basis for future studies to determine the feasibility of Raman spectroscopy and Raman chemical imaging for condom lubricant trace detection in case type samples. ..
  28. Yang Y, Shen L, Wei K, Zhao Q. Cyclization approaching to (-)-lycojapodine A: synthesis of two unnatural alkaloids. J Org Chem. 2010;75:1317-20 pubmed publisher
    Two unnatural alkaloids were observed for the first time while attempting to initiate a plausibly biomimetic cyclization approaching to (-)-lycojapodine A, one of the newest Lycopodium alkaloids.
  29. Sacher J, Weinreb S. Construction of the azocane (azacyclooctane) moiety of the Lycopodium alkaloid lycopladine H via an intramolecular hydroaminomethylation strategy. Org Lett. 2012;14:2172-5 pubmed publisher
    ..2.2]octane scaffold via an intramolecular hydroaminomethylation protocol to generate an advanced intermediate bearing three of the four rings of the structurally unique Lycopodium alkaloid lycopladine H (1).
  30. Shi H, Li Z, Guo Y. A new serratane-type triterpene from Lycopodium phlegmaria. Nat Prod Res. 2005;19:777-81 pubmed
    A new serratane-type triterpene, lycophlegmarin (1), has been isolated from Lycopodium phlegmaria L. Four known related triterpenoids were also found from the title plant...
  31. Koyama K, Hirasawa Y, Kobayashi J, Morita H. Cryptadines A and B, novel C27N3-type pentacyclic alkaloids from Lycopodium cryptomerinum. Bioorg Med Chem. 2007;15:7803-8 pubmed
    Two novel C(27)N(3)-type Lycopodium alkaloids, cryptadines A (1) and B (2) consisting of two octahydroquinoline rings (C(11)N) and a piperidine ring (C(5)N), have been isolated from the club moss Lycopodium cryptomerinum, and their ..
  32. Chandra A, Pigza J, Han J, Mutnick D, Johnston J. Total synthesis of the lycopodium alkaloid (+)-serratezomine A. J Am Chem Soc. 2009;131:3470-1 pubmed publisher
    ..Overall, 15 steps (longest linear sequence) are required to prepare the natural product from a commercially available aldehyde, and assembly of the contiguous array of six stereocenters is accomplished with high stereocontrol. ..
  33. Veerasamy N, Carlson E, Carter R. Expedient enantioselective synthesis of cermizine D. Org Lett. 2012;14:1596-9 pubmed publisher
  34. Renzaglia K, Whittier D. Microanatomy of the placenta of Lycopodium obscurum: novel design in an underground embryo. Ann Bot. 2013;112:1083-8 pubmed publisher
    ..Gametophytes with attached embryos/young sporophytes of Lycopodium obscurum were collected in nature, processed and examined by light and transmission electron microscopy...
  35. Brustolin Aleixo C, Ferraz F, Massini P, Lopes C, Falkowski Temporini G, Aleixo D, et al. Beneficial immunomodulatory and neuro digestive effect in Trypanosoma cruzi infection after Lycopodium clavatum 13c treatment. Microb Pathog. 2017;112:1-4 pubmed publisher
    ..The present study evaluated the effects of Lycopodium clavatum, dynamization 13c, in Wistar rats infected with T. cruzi...
  36. Katakawa K, Nozoe A, Kogure N, Kitajima M, Hosokawa M, Takayama H. Fawcettimine-related alkaloids from Lycopodium serratum. J Nat Prod. 2007;70:1024-8 pubmed
    Five new Lycopodium alkaloids (1-5) having the fawcettimine skeleton were isolated from Lycopodium serratum. The structures of the alkaloids were elucidated on the basis of spectroscopic analysis...
  37. Hirasawa Y, Kato E, Kobayashi J, Kawahara N, Goda Y, Shiro M, et al. Lycoparins A-C, new alkaloids from Lycopodium casuarinoides inhibiting acetylcholinesterase. Bioorg Med Chem. 2008;16:6167-71 pubmed publisher
    Three new Lycopodium alkaloids, lycoparins A-C (1-3), have been isolated from the club moss Lycopodium casuarinoides. Structures and stereochemistry of 1-3 were elucidated on the basis of 2D NMR correlations...
  38. Zhao Y, Deng T, Chen Y, Liu X, Yang G. Two new triterpenoids from Lycopodium obscurum L. J Asian Nat Prod Res. 2010;12:666-71 pubmed publisher
    ..3 alpha,8 beta,14 alpha,21 beta)-26,27-dinoronocerane-3,8,14,21-tetrol (1) and 26-nor-8 beta-hydroxy-alpha-onocerin (2), were isolated from Lycopodium obscurum L. Their structures were elucidated on the basis of spectroscopic analyses.
  39. Bainard J, Henry T, Bainard L, Newmaster S. DNA content variation in monilophytes and lycophytes: large genomes that are not endopolyploid. Chromosome Res. 2011;19:763-75 pubmed publisher
    ..06 pg for the Polypodiales. There was no indication of endoreduplication in any of the leaf, stem, or root tissue analyzed. This information is essential to our understanding of DNA content evolution in land plants. ..
  40. Shrivastava J, Kumar A, Bhatnagar V. Aspergillus niger as a new allergic agent associated with bindis and its efficacy against homeopathic drugs. J Environ Biol. 2006;27:705-7 pubmed
    ..Among three potencies of four homeopathic drugs, Lycopodium 1M, Sulphur 1M, and Sepia 30 showed maximum inhibition zone of Aspergillus niger in inhibition zone technique...
  41. Pathak S, Bhattacharjee N, Das J, Choudhury S, Karmakar S, Banerjee P, et al. Supportive evidence for the anticancerous potential of alternative medicine against hepatocarcinogenesis in mice. Forsch Komplementmed. 2007;14:148-56 pubmed
    The present study examines if Lycopodium 200 (Lyco-200) has demonstrable anti-cancer activities in mice which are chronically fed carcinogens, p-dimethylaminoazobenzene (p-DAB) and phenobarbital (PB) to induce liver cancer...
  42. Kubota T, Yahata H, Yamamoto S, Hayashi S, Shibata T, Kobayashi J. Serratezomines D and E, new Lycopodium alkaloids from Lycopodium serratum var. serratum. Bioorg Med Chem Lett. 2009;19:3577-80 pubmed publisher
    Two new Lycopodium alkaloids, serratezomines D (1) and E (2), were isolated from the club moss Lycopodium serratum var. serratum...
  43. Zhang Y, Xie J, Chen W, Zhou T, Lu W. Development of a sensitive high-performance liquid chromatographic method with simple extraction for simultaneous determination of huperzine A and huperzine B in the species containing lycopodium alkaloids. J AOAC Int. 2009;92:1060-3 pubmed
    ..The satisfactory results indicated that the developed method can readily be utilized for quality control of the species of Huperziaceae and Lycopodiaceae containing the two compounds...
  44. Nguyen V, Zhao B, Seong S, Kim J, Woo M, Choi J, et al. Inhibitory effects of serratene-type triterpenoids from Lycopodium complanatum on cholinesterases and ?-secretase 1. Chem Biol Interact. 2017;274:150-157 pubmed publisher
    Phytochemical investigation of Lycopodium complanatum whole plants led to the isolation of two new serratene-type triterpenoids (1 and 2) along with eight known triterpenoids (3-10)...
  45. Almeida A, Dong L, Khakimov B, Bassard J, Moses T, Lota F, et al. A Single Oxidosqualene Cyclase Produces the Seco-Triterpenoid α-Onocerin. Plant Physiol. 2018;176:1469-1484 pubmed publisher
    ..The 8,14-seco-triterpenoid α-onocerin is only known from the evolutionarily distant clubmoss genus Lycopodium and the leguminous genus Ononis, which makes the biosynthesis of this seco-triterpenoid ..
  46. Kobayashi J, Morita H. The Lycopodium alkaloids. Alkaloids Chem Biol. 2005;61:1-57 pubmed
  47. Choo C, Hirasawa Y, Karimata C, Koyama K, Sekiguchi M, Kobayashi J, et al. Carinatumins A-C, new alkaloids from Lycopodium carinatum inhibiting acetylcholinesterase. Bioorg Med Chem. 2007;15:1703-7 pubmed
    Three new Lycopodium alkaloids, carinatumins A-C (1-3), have been isolated from the club moss Lycopodium carinatum. Structures and stereochemistry of 1-3 were elucidated on the basis of 2D NMR correlations...
  48. Howarth J, Coulson S, Newton A. Simulating transfer and persistence of a chemical marker powder for Lycopodium clavatum spores. Forensic Sci Int. 2009;192:72-7 pubmed publisher
    In this research a chemical marker powder, based on Lycopodium clavatum spores, was studied to determine its transfer and persistence on a T-shirt...
  49. Kitajima M, Takayama H. Lycopodium alkaloids: isolation and asymmetric synthesis. Top Curr Chem. 2012;309:1-31 pubmed publisher
    b>Lycopodium alkaloids have attracted the attention of many natural product chemists and synthetic organic chemists due to their important biological activities and unique skeletal characteristics...
  50. Dong L, Yang J, He J, Luo H, Wu X, Deng X, et al. Lycopalhine A, a novel sterically congested Lycopodium alkaloid with an unprecedented skeleton from Palhinhaea cernua. Chem Commun (Camb). 2012;48:9038-40 pubmed publisher
    A novel sterically congested Lycopodium alkaloid named lycopalhine A (1) that possesses a fused hexacyclic (5/5/5/6/6/6) ring system comprising a 5,9-diaza-tricyclo[6.2.1.0(4,9)]undecane moiety and a tricyclo[5.2.1...
  51. Ding R, Sun B, Lin G. An efficient total synthesis of (-)-huperzine A. Org Lett. 2012;14:4446-9 pubmed publisher
    The total synthesis of Lycopodium alkaloid (-)-huperzine A has been accomplished in 10 steps with 17% overall yield from commercially abundant (R)-pulegone...
  52. Zhang H. New insights into huperzine A for the treatment of Alzheimer's disease. Acta Pharmacol Sin. 2012;33:1170-5 pubmed publisher
    Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD)..
  53. Ishiuchi K, Kodama S, Kubota T, Hayashi S, Shibata T, Kobayashi J. Lannotinidines H-J, new Lycopodium alkaloids from Lycopodium annotinum. Chem Pharm Bull (Tokyo). 2009;57:877-81 pubmed
    Three new Lycopodium alkaloids, lannotinidines H-J (1-3), were isolated from the club moss Lycopodium annotinum...
  54. Puiatti M, Borioni J, Vallejo M, Cabrera J, Agnese A, Ortega M, et al. Study of the interaction of Huperzia saururus Lycopodium alkaloids with the acetylcholinesterase enzyme. J Mol Graph Model. 2013;44:136-44 pubmed publisher
    In the present study, we describe and compare the binding modes of three Lycopodium alkaloids (sauroine, 6-hydroxylycopodine and sauroxine; isolated from Huperzia saururus) and huperzine A with the enzyme acetylcholinesterase...
  55. Ahmad N, Kamboh M, Nodeh H, Halim S, Mohamad S. Synthesis of piperazine functionalized magnetic sporopollenin: a new organic-inorganic hybrid material for the removal of lead(II) and arsenic(III) from aqueous solution. Environ Sci Pollut Res Int. 2017;24:21846-21858 pubmed publisher
    The present work describes the successful functionalization/magnetization of bio-polymeric spores of Lycopodium clavatum (sporopollenin) with 1-(2-hydroxyethyl) piperazine. Analytical techniques, i.e...
  56. Bormashenko E, Frenkel M, Bormashenko Y, Chaniel G, Valtsifer V, Binks B. Superposition of Translational and Rotational Motions under Self-Propulsion of Liquid Marbles Filled with Aqueous Solutions of Camphor. Langmuir. 2017;33:13234-13241 pubmed publisher
    Self-locomotion of liquid marbles, coated with lycopodium or fumed fluorosilica powder, filled with a saturated aqueous solution of camphor and placed on a water/vapor interface is reported...
  57. Katakawa K, Kitajima M, Aimi N, Seki H, Yamaguchi K, Furihata K, et al. Structure elucidation and synthesis of lycoposerramine-B, a novel oxime-containing Lycopodium alkaloid from Lycopodium serratum Thunb. J Org Chem. 2005;70:658-63 pubmed
    A new alkaloid, lycoposerramine-B (1), containing an oxime function, was isolated from the club moss Lycopodium serratum Thunb...
  58. Leake J, Cameron D, Beerling D. Fungal fidelity in the myco-heterotroph-to-autotroph life cycle of Lycopodiaceae: a case of parental nurture?. New Phytol. 2008;177:572-6 pubmed publisher
  59. Du Z, Du T, Wang Z, Li G. [Study on extraction process of zhanjin ruji]. Zhongguo Zhong Yao Za Zhi. 2003;28:32-4 pubmed
    ..To select the optimum extraction process of Zhanjin Ruji...
  60. Ishiuchi K, Kubota T, Hoshino T, Obara Y, Nakahata N, Kobayashi J. Lycopladines B-D and lyconadin B, new alkaloids from Lycopodium complanatum. Bioorg Med Chem. 2006;14:5995-6000 pubmed
    Four new alkaloids, lycopladines B-D (1-3) and lyconadin B (4), have been isolated from the club moss Lycopodium complanatum and the structures including the stereochemistry were elucidated on the basis of spectral data and modified ..
  61. Shigeyama T, Katakawa K, Kogure N, Kitajima M, Takayama H. Asymmetric total syntheses of two phlegmarine-type alkaloids, lycoposerramines-V and -W, newly isolated from Lycopodium serratum. Org Lett. 2007;9:4069-72 pubmed
    Two new Phlegmarine-type alkaloids, lycoposerramines-V and -W, were isolated from Lycopodium serratum, and their structures including the absolute configuration were established by asymmetric total synthesis involving such key steps as ..
  62. Kozaka T, Miyakoshi N, Mukai C. Stereoselective total syntheses of three Lycopodium alkaloids, (-)-magellanine, (+)-magellaninone, and (+)-paniculatine, based on two Pauson-Khand reactions. J Org Chem. 2007;72:10147-54 pubmed
    ..3.0]skeleton, which could be converted into the C and D rings of the target natural products...
  63. West S, Bisai A, Lim A, Narayan R, Sarpong R. Total synthesis of (+)-lyconadin A and related compounds via oxidative C-N bond formation. J Am Chem Soc. 2009;131:11187-94 pubmed publisher
    ..In the context of the synthesis of the architecturally complex Lycopodium alkaloid lyconadin A, we have discovered a highly efficient oxidative C-N bond forming reaction that relies on ..
  64. Gubbuk I. Isotherms and thermodynamics for the sorption of heavy metal ions onto functionalized sporopollenin. J Hazard Mater. 2011;186:416-22 pubmed publisher
    In this study, sporopollenin of Lycopodium clavatum spores was used for the sorption experiment. Glutaraldehyde (GA) immobilized sporopollenin (Sp), is employed as a sorbent in sorption of selected heavy metal ions...
  65. Yang Y, Shen L, Huang J, Xu T, Wei K. Application of the Helquist annulation in Lycopodium alkaloid synthesis: unified total syntheses of (-)-8-deoxyserratinine, (+)-fawcettimine, and (+)-lycoflexine. J Org Chem. 2011;76:3684-90 pubmed publisher
    A unified strategy for total synthesis of the Lycopodium alkaloids (-)-8-deoxyserratinine (7), (+)-fawcettimine (1), and (+)-lycoflexine (4) is detailed...
  66. Li H, Wang X, Lei X. Total syntheses of Lycopodium alkaloids (+)-fawcettimine, (+)-fawcettidine, and (-)-8-deoxyserratinine. Angew Chem Int Ed Engl. 2012;51:491-5 pubmed publisher
    A shared story: Three fawcettimine- and serratinine-type Lycopodium alkaloids are prepared from a common tetracyclic spirodiketone intermediate in concise total syntheses...
  67. Braun H, Cardoso A. Self-assembly of Fmoc-diphenylalanine inside liquid marbles. Colloids Surf B Biointerfaces. 2012;97:43-50 pubmed publisher
    Liquid marbles made from Lycopodium clavatum spores are used to encapsulate aqueous solutions of 9-fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF)...
  68. Das S, Das J, Paul A, Samadder A, Khuda Bukhsh A. Apigenin, a bioactive flavonoid from Lycopodium clavatum, stimulates nucleotide excision repair genes to protect skin keratinocytes from ultraviolet B-induced reactive oxygen species and DNA damage. J Acupunct Meridian Stud. 2013;6:252-62 pubmed publisher
    ..examined the antioxidative and the DNA protective potentials of apigenin, a flavonoid polyphenol isolated from Lycopodium clavatum, in both in-vitro (HaCaT skin keratinocytes) and in-vivo (mice) models against UV-B radiation...
  69. Martin C, Lin T, Lin K, Hsu C, Chiou W. Causes and consequences of high osmotic potentials in epiphytic higher plants. J Plant Physiol. 2004;161:1119-24 pubmed
  70. Watson J, Sephton M, Sephton S, Self S, Fraser W, Lomax B, et al. Rapid determination of spore chemistry using thermochemolysis gas chromatography-mass spectrometry and micro-Fourier transform infrared spectroscopy. Photochem Photobiol Sci. 2007;6:689-94 pubmed
    ..Our method was tested using spores obtained from five populations of the tropical lycopsid Lycopodium cernuum growing across an altitudinal gradient (650-1981 m a.s.l.) in S.E...
  71. Zhao C, Zheng H, Jing P, Fang B, Xie X, She X. Tandem oxidative dearomatization/intramolecular Diels-Alder reaction for construction of the tricyclic core of palhinine A. Org Lett. 2012;14:2293-5 pubmed publisher
    A concise construction of the 6/6/5 tricyclic core of Lycopodium alkaloid palhinine A (1) has been accomplished...
  72. Hsieh Y, Harris P. Structures of xyloglucans in primary cell walls of gymnosperms, monilophytes (ferns sensu lato) and lycophytes. Phytochemistry. 2012;79:87-101 pubmed publisher
    ..The two species of lycophytes examined, Selaginella kraussiana and Lycopodium cernuum, had quite different xyloglucan oligosaccharide profiles, but neither were fucogalactoxyloglucans. The S...
  73. Ham Y, Yoon W, Park S, Jung Y, Kim D, Jeon Y, et al. Investigation of the component of Lycopodium serratum extract that inhibits proliferation and mediates apoptosis of human HL-60 leukemia cells. Food Chem Toxicol. 2012;50:2629-34 pubmed publisher
    In this study, we investigate a plant commonly used in herbal medicines, Lycopodium serratum, which is believed to have anti-cancer properties. An alcoholic extract of L...
  74. Araki T, Saga Y, Marugami M, Otaka J, Araya H, Saito K, et al. Onocerin Biosynthesis Requires Two Highly Dedicated Triterpene Cyclases in a Fern Lycopodium clavatum. Chembiochem. 2016;17:288-90 pubmed publisher
    ..Two genes, LCC and LCD, were identified from the fern Lycopodium clavatum. Expression in yeast revealed that both were required to produce α-onocerin...
  75. Hirasawa Y, Morita H, Shiro M, Kobayashi J. Sieboldine A, a novel tetracyclic alkaloid from Lycopodium sieboldii, inhibiting acetylcholinesterase. Org Lett. 2003;5:3991-3 pubmed
    structure: see text] A novel Lycopodium alkaloid with an unprecedented fused-tetracyclic ring system consisting of an aza-cyclononane ring having a N-hydroxy group, a cyclohexanone, a cyclopentanone, and a tetrahydrofuran ring, ..
  76. Hirasawa Y, Tanaka T, Kobayashi J, Kawahara N, Goda Y, Morita H. Malycorins A--C, New lycopodium alkaloids from Lycopodium phlegmaria. Chem Pharm Bull (Tokyo). 2008;56:1473-6 pubmed
    A novel C(19)N-type Lycopodium alkaloid, malycorin A (1) consisting of a serratinane skeleton with 2-propanol unit has been isolated from the club moss Lycopodium phlegmaria, together with two new C(16)N-type alkaloids, malycorins B (2) ..
  77. Orhan I, Ozcelik B, Aslan S, Kartal M, Karaoglu T, Sener B, et al. In vitro biological activity screening of Lycopodium complanatum L. ssp. chamaecyparissus (A. Br.) Doll. Nat Prod Res. 2009;23:514-26 pubmed publisher
    ..properties, of the petroleum ether, chloroform and methanol extracts as well as the alkaloid fraction of Lycopodium complanatum L. ssp. chamaecyparissus (A. Br.) Doll (LCC, Lycopodiaceae) growing in Turkey...
  78. Li B, Zhang W, He Y, Lu L, Kong D, Shen Y. New alkaloids from Lycopodium japonicum. Chem Pharm Bull (Tokyo). 2012;60:1448-52 pubmed
    ..1-3), together with ten known alkaloids, were isolated from the ethanolic extract of the whole plants of Lycopodium japonicum THUNB...
  79. Pan K, Luo J, Kong L. Three new Lycopodium alkaloids from Lycopodium obscurum. J Asian Nat Prod Res. 2013;15:441-5 pubmed publisher
    Chemical investigation on the crude alkaloid portion of Lycopodium obscurum led to isolation of three new fawcettimine-type Lycopodium alkaloids, lycobscurines A-C (1-3), together with three known compounds...
  80. Rollinger J, Ewelt J, Seger C, Sturm S, Ellmerer E, Stuppner H. New insights into the acetylcholinesterase inhibitory activity of Lycopodium clavatum. Planta Med. 2005;71:1040-3 pubmed
    ..2 microM) of Lycopodium clavatum L...
  81. Bormashenko E, Grynyov R. Plasma treatment allows water suspending of the natural hydrophobic powder (lycopodium). Colloids Surf B Biointerfaces. 2012;97:171-4 pubmed publisher
    b>Lycopodium particles which are spores of the plant Lycopodium clavatum were exposed to cold oxygen and nitrogen plasma irradiation. Wetting properties of the particles changed dramatically from hydrophobic to hydrophilic...
  82. Ge H, Zhang L, Tan R, Yao Z. Protecting group-free total synthesis of (-)-lannotinidine B. J Am Chem Soc. 2012;134:12323-5 pubmed publisher
    The first total synthesis of (-)-lannotinidine B, a unique tetracyclic constitutent of Lycopodium annotinum, has been accomplished in 10 steps with 23% overall yield...
  83. Ochi Y, Yokoshima S, Fukuyama T. Total Synthesis of Lycopalhine A. Org Lett. 2016;18:1494-6 pubmed publisher
  84. Es S, Kuttan G, Kc P, Kuttan R. Effect of homeopathic medicines on transplanted tumors in mice. Asian Pac J Cancer Prev. 2007;8:390-4 pubmed
    ..These findings support that homeopathic preparations of Ruta and Hydrastis have significant antitumour activity. The mechanism of action of these medicines is not known at present...
  85. Boonsompat J, Padwa A. An IMDAF cycloaddition approach toward the synthesis of the lycopodium alkaloid (±)-fawcettidine. J Org Chem. 2011;76:2753-61 pubmed publisher
    ..4]non-7-en-7-yl)-N-furan-2-ylpropionamide (23) as the key step, the BCD core of the lycopodium alkaloid fawcettidine was constructed...
  86. Murphy R, Sarpong R. Direct methoxypyridine functionalization approach to magellanine-type Lycopodium alkaloids. Org Lett. 2012;14:632-5 pubmed publisher
    A concise enantioselective approach to the tetracyclic core of the magellanine-type Lycopodium alkaloids is reported...
  87. Wang X, Liu Y, Li L, Yu S, Lv H, Ma S, et al. Lycojaponicumins D and E: two new alkaloids from Lycopodium japonicum. Org Lett. 2012;14:5688-91 pubmed publisher
    Two new alkaloids, lycojaponicumins D (1) and E (2), were isolated from the club moss Lycopodium japonicum. Their structures were elucidated by spectroscopic methods, calculated ECD, CD experiments and X-ray diffraction analysis...
  88. Orhan I, Terzioglu S, Sener B. Alpha-onocerin: an acetylcholinesterase inhibitor from Lycopodium clavatum. Planta Med. 2003;69:265-7 pubmed
    ..potential in the treatment of Alzheimer's disease, the chloroform : methanol (1 : 1) extracts of five Lycopodium species ( L. clavatum L., L. selago L., L. annotinum L., L. alpinum L., and L. complanatum ssp...
  89. Takayama H, Katakawa K, Kitajima M, Yamaguchi K, Aimi N. Ten new Lycopodium alkaloids having the lycopodane skeleton isolated from Lycopodium serratum Thunb. Chem Pharm Bull (Tokyo). 2003;51:1163-9 pubmed
    ..6), -L (7), -M (8), -N (9), and -O (10), having lycopodine-related structures, were isolated from the club moss Lycopodium serratum THUNB...
  90. Liau B, Shair M. Total synthesis of (+)-fastigiatine. J Am Chem Soc. 2010;132:9594-5 pubmed publisher
    The first total synthesis of the Lycopodium alkaloid (+)-fastigiatine has been accomplished in 15 steps and 30% overall yield from known compounds...
  91. Ramharter J, Weinstabl H, Mulzer J. Synthesis of the lycopodium alkaloid (+)-lycoflexine. J Am Chem Soc. 2010;132:14338-9 pubmed publisher
    The first total synthesis of (+)-lycoflexine (1), a constituent of Lycopodium clavatum var. inflexum , has been accomplished in eight steps with 13% overall yield...
  92. Atkin S, Barrier S, Cui Z, Fletcher P, Mackenzie G, Panel V, et al. UV and visible light screening by individual sporopollenin exines derived from Lycopodium clavatum (club moss) and Ambrosia trifida (giant ragweed). J Photochem Photobiol B. 2011;102:209-17 pubmed publisher
    ..UV-visible light transmission of three types of micrometre-sized sporopollenin exine shells, two derived from Lycopodium clavatum (club moss) spores and one from Ambrosia trifida (giant ragweed) pollen...