huperzia

Summary

Summary: A plant genus of the family LYCOPODIACEAE. Members contain huperzine, one of the CHOLINESTERASE INHIBITORS.

Top Publications

  1. Hnatyszyn O, Moscatelli V, Garcia J, Rondina R, Costa M, Arranz C, et al. Argentinian plant extracts with relaxant effect on the smooth muscle of the corpus cavernosum of guinea pig. Phytomedicine. 2003;10:669-74 pubmed
    Extracts of different polarity from Baccharis trimera, Haplopappus rigidus Huperzia saururus, Maytenus ilicifolia, Satureja parvifolia and Senecio eriophyton were tested for their relaxant activity on smooth muscle using L-phenylephrine ..
  2. Wolf P, Karol K, Mandoli D, Kuehl J, Arumuganathan K, Ellis M, et al. The first complete chloroplast genome sequence of a lycophyte, Huperzia lucidula (Lycopodiaceae). Gene. 2005;350:117-28 pubmed
    We used a unique combination of techniques to sequence the first complete chloroplast genome of a lycophyte, Huperzia lucidula...
  3. Ma X, Tan C, Zhu D, Gang D, Xiao P. Huperzine A from Huperzia species--an ethnopharmacolgical review. J Ethnopharmacol. 2007;113:15-34 pubmed
    Huperzine A (HupA), isolated originally from a traditional Chinese medicine Qiang Ceng Ta, whole plant of Huperzia serrata (Thunb. ex Murray) Trev...
  4. Lim W, Goodger J, Field A, Holtum J, Woodrow I. Huperzine alkaloids from Australasian and southeast Asian Huperzia. Pharm Biol. 2010;48:1073-8 pubmed publisher
    ..currently used in herbal supplements and medicines worldwide, is predominantly sourced from the Chinese lycopod Huperzia serrata (Thunb. ex Murray) Trev. (Lycopodiaceae), which on average contains only 0...
  5. Luo H, Li Y, Sun C, Wu Q, Song J, Sun Y, et al. Comparison of 454-ESTs from Huperzia serrata and Phlegmariurus carinatus reveals putative genes involved in lycopodium alkaloid biosynthesis and developmental regulation. BMC Plant Biol. 2010;10:209 pubmed publisher
    Plants of the Huperziaceae family, which comprise the two genera Huperzia and Phlegmariurus, produce various types of lycopodium alkaloids that are used to treat a number of human ailments, such as contusions, swellings and strains...
  6. Liu Y, Wang B, Cui P, Li L, Xue J, Yu J, et al. The mitochondrial genome of the lycophyte Huperzia squarrosa: the most archaic form in vascular plants. PLoS ONE. 2012;7:e35168 pubmed publisher
    ..In this study, we provide the completely sequenced mitochondrial genome of a lycophyte, from Huperzia squarrosa, which is a member of the sister group to all other vascular plants...
  7. Wang Y, Zeng Q, Zhang Z, Yan R, Wang L, Zhu D. Isolation and characterization of endophytic huperzine A-producing fungi from Huperzia serrata. J Ind Microbiol Biotechnol. 2011;38:1267-78 pubmed publisher
    b>Huperzia serrata is a producer of huperzine A (HupA), a cholinesterase inhibitor (ChEI). Over 120 endophytic fungi were recovered from this plant and screened for Hup-A and nine were found...
  8. Luo H, Sun C, Li Y, Wu Q, Song J, Wang D, et al. Analysis of expressed sequence tags from the Huperzia serrata leaf for gene discovery in the areas of secondary metabolite biosynthesis and development regulation. Physiol Plant. 2010;139:1-12 pubmed publisher
    b>Huperzia serrata produces various types of lycopodium alkaloids, especially the huperzine A (HupA) that is a promising drug candidate for Alzheimer's disease. Despite the medicinal importance of H...
  9. Zhou H, Li Y, Tong X, Liu H, Jiang S, Zhu D. Serratane-type triterpenoids from Huperzia serrata. Nat Prod Res. 2004;18:453-9 pubmed
    ..2) and serrat-14-en-3alpha,21beta,24,29-tetraol (3), were isolated from the whole plant of Huperzia serrata (Thunb) Trev...

More Information

Publications95

  1. Ma X, Tan C, Zhu D, Gang D. A survey of potential huperzine A natural resources in China: the Huperziaceae. J Ethnopharmacol. 2006;104:54-67 pubmed
    The Huperziaceae is comprised of two genera, Huperzia and Phlegmariurus...
  2. Wanibuchi K, Zhang P, Abe T, Morita H, Kohno T, Chen G, et al. An acridone-producing novel multifunctional type III polyketide synthase from Huperzia serrata. FEBS J. 2007;274:1073-82 pubmed
    A cDNA encoding a novel plant type III polyketide synthase was cloned and sequenced from the Chinese club moss Huperzia serrata (Huperziaceae). The deduced amino acid sequence of Hu...
  3. Ma X, Gang D. In vitro production of huperzine A, a promising drug candidate for Alzheimer's disease. Phytochemistry. 2008;69:2022-8 pubmed publisher
    ..Huperzine A (HupA), a anti-AD drug candidate from the traditional Chinese medicine Qian Ceng Ta (Huperzia serrata), has been shown to be a powerful and selective inhibitor of acetylcholinesterase and has attracted ..
  4. Fu S, Yang J, Cui J, Feng X, Sun D. Biotransformation of ursolic acid by an endophytic fungus from medicinal plant Huperzia serrata. Chem Pharm Bull (Tokyo). 2011;59:1180-2 pubmed
    ..An endophytic fungus, isolated from medicinal plant Huperzia serrata, was identified as Umbelopsis isabellina based on the internal transcribed spacer of ribosomal DNA (rDNA-..
  5. Fu S, Yang J, Cui J, Meng Q, Feng X, Sun D. Multihydroxylation of ursolic acid by Pestalotiopsis microspora isolated from the medicinal plant Huperzia serrata. Fitoterapia. 2011;82:1057-61 pubmed publisher
    ..modification of ursolic acid by an endophytic fungus Pestalotiopsis microspora, isolated from medicinal plant Huperzia serrata was reported for the first time...
  6. Tong X, Tan C, Ma X, Wang B, Jiang S, Zhu D. Miyoshianines A and B, two new lycopodium alkaloids from Huperzia miyoshiana. Planta Med. 2003;69:576-9 pubmed
    ..five known alkaloids, lycopodine, lycodoline, 12-epilycodoline, clavolonine, and flabelliformine, were isolated from Huperzia miyoshiana (Makino) Ching (Huperziaceae). Their structures were determined by means of spectroscopic techniques.
  7. Zhou H, Jiang S, Tan C, Wang B, Zhu D. New epoxyserratanes from Huperzia serrata. Planta Med. 2003;69:91-4 pubmed
    Three new serratane-type epoxytriterpenoids were isolated from the whole plant of Huperzia serrata...
  8. Ma X, Tan C, Zhu D, Gang D. Is there a better source of huperzine A than Huperzia serrata? Huperzine A content of Huperziaceae species in China. J Agric Food Chem. 2005;53:1393-8 pubmed
    ..This method was used to quantify the levels of HupA in samples of Huperzia serrata collected from a single population at different times of the year, in different organs of the same H...
  9. Ortega M, Agnese A, Cabrera J. Anticholinesterase activity in an alkaloid extract of Huperzia saururus. Phytomedicine. 2004;11:539-43 pubmed
    b>Huperzia saururus (Lam.) Trevis. (Lycopodiaceae) is used widely in Argentinian traditional medicine as an aphrodisiac and for memory improvement...
  10. Sun J, Morita H, Chen G, Noguchi H, Abe I. Molecular cloning and characterization of copper amine oxidase from Huperzia serrata. Bioorg Med Chem Lett. 2012;22:5784-90 pubmed publisher
    A cDNA encoding a novel copper amine oxidase (CAO) was cloned and sequenced from the Chinese club moss Huperzia serrata (Huperziaceae), which produces the Lycopodium alkaloid huperzine A...
  11. Zhu D, Wang J, Zeng Q, Zhang Z, Yan R. A novel endophytic Huperzine A-producing fungus, Shiraia sp. Slf14, isolated from Huperzia serrata. J Appl Microbiol. 2010;109:1469-78 pubmed publisher
    To characterize and identify a novel Huperzine A (HupA)-producing fungal strain Slf14 isolated from Huperzia serrata (Thunb. ex Murray) Trev. in China.
  12. Yang H, Peng S, Zhang Z, Yan R, Wang Y, Zhan J, et al. Molecular cloning, expression, and functional analysis of the copper amine oxidase gene in the endophytic fungus Shiraia sp. Slf14 from Huperzia serrata. Protein Expr Purif. 2016;128:8-13 pubmed publisher
    ..This is the first report on the cloning and expression of a CAO gene from HupA-producing endophytic fungi. Functional characterization of this enzyme provides new insights into the biosynthesis of the HupA an anti-Alzheimer's drug. ..
  13. Antar V, Baran O, Yuceli S, Erdogan H, Altıntaş O, Baran G, et al. Assessment of the neuroprotective effects of the acetylcholinesterase inhibitor huperzine A in an experimental spinal cord trauma model. J Neurosurg Sci. 2018;62:128-139 pubmed publisher
    ..In addition, the group treated with huperzine A showed significant and appreciable neurological improvement in rats. ..
  14. Yu L, Shi Y, Huang J, Gong Y, Liu Z, Hu W. Modification and validation of a high-performance liquid chromatography method for quantification of Huperzine A in Huperzia crispata. J AOAC Int. 2010;93:1428-35 pubmed
    The present study describes a rapid and sensitive HPLC method for the quantification of huperzine A (HupA) in Huperzia crispata (Huperziaceae)...
  15. Chen Y, Yang Y, Li X, Zou C, Zhao P. Diterpenoids from the Endophytic Fungus Botryosphaeria sp. P483 of the Chinese Herbal Medicine Huperzia serrata. Molecules. 2015;20:16924-32 pubmed publisher
    ..All of the isolated compounds were tested for activity against phytopathogenic fungi and nematodes. Compounds 2 and 3 showed antifungal activity and compound 2 showed weak nematicidal activity. ..
  16. Zuo Z, Wang Y, Liu L, Wang Y, Mei S, Feng Z, et al. Huperzine A Alleviates Mechanical Allodynia but Not Spontaneous Pain via Muscarinic Acetylcholine Receptors in Mice. Neural Plast. 2015;2015:453170 pubmed publisher
    ..Previous studies suggest that Huperzine A (Hup A), an alkaloid isolated from the Chinese herb Huperzia serrata, is a potent analgesic with few side effects. However, whether it alleviates spontaneous pain is unclear...
  17. Tung B, Hai N, Thu D. Antioxidant and acetylcholinesterase inhibitory activities in vitro of different fraction of Huperzia squarrosa (Forst.) Trevis extract and attenuation of scopolamine-induced cognitive impairment in mice. J Ethnopharmacol. 2017;198:24-32 pubmed publisher
    b>Huperzia squarrosa (Forst.) Trevis is used in traditional medicine for improving memory deficits. Alkaloids, triterpenoids, flavonoids are main bioactive compounds of Huperzia squarrosa (Forst.) Trevis...
  18. Wang Z, Xu J, Yu X, Shen S. [Effect of environmental factors on growth of Huperzia serrata]. Zhongguo Zhong Yao Za Zhi. 2008;33:1814-6 pubmed
    To establish and optimize the cultivation systems for wild Huperzia serrata, through assessing the effects of environmental factors on its growth. H. serrata was planted under natural field condition, the growth status of H...
  19. Tan C, Chen G, Ma X, Jiang S, Zhu D. Huperzine R, a novel 15-carbon Lycopodium alkaloid from Huperzia serrata. J Nat Prod. 2002;65:1021-2 pubmed
    Huperzine R (2), a novel 15-carbon Lycopodium alkaloid, was isolated from the whole plant of Huperzia serrata, and the relative configuration was established using spectroscopic and X-ray crystallographic techniques.
  20. Russo P, Frustaci A, Del Bufalo A, Fini M, Cesario A. Multitarget drugs of plants origin acting on Alzheimer's disease. Curr Med Chem. 2013;20:1686-93 pubmed
    ..This review is limited to plant chemicals having different targets with actual (galantamine) or promising (drugs from Crocus sativus, Ginkgo biloba, Salvia species, and Huperzia serrata) clinical evidence in people with dementia or AD.
  21. Odorcyk F, Sanches E, Nicola F, Moraes J, Pettenuzzo L, Kolling J, et al. Administration of Huperzia quadrifariata Extract, a Cholinesterase Inhibitory Alkaloid Mixture, has Neuroprotective Effects in a Rat Model of Cerebral Hypoxia-Ischemia. Neurochem Res. 2017;42:552-562 pubmed publisher
    ..The administration of Huperzia quadrifariata alkaloid extract (HqAE), with potent and selective cholinesterase inhibitor properties, will reduce ..
  22. Lenkiewicz A, Czapski G, Jesko H, Wilkaniec A, Szypuła W, Pietrosiuk A, et al. Potent effects of alkaloid-rich extract from Huperzia selago against sodium nitroprusside-evoked PC12 cells damage via attenuation of oxidative stress and apoptosis. Folia Neuropathol. 2016;54:156-66 pubmed
    ..In our studies we focused on alkaloid fractions (AFs) isolated from club moss, Huperzia selago and Diphasiastrum complanatum, due to their beneficial activity and exclusive chemical structure...
  23. Li N, Chen J, Cheng X, Zhu D. [Effects of microbes on rooting and on several physiological and biochemical indexes of cuttings of Huperzia serrata]. Zhongguo Zhong Yao Za Zhi. 2008;33:873-7 pubmed
    To study the effects of soil microbes of habitats, endophytic fungi and root surface fungi of Huperzia serrata on rooting rate of the cuttings and on several physiological and biochemical indexes. The cuttings of H...
  24. Armijos C, Gilardoni G, Amay L, Lozano A, Bracco F, Ramirez J, et al. Phytochemical and ethnomedicinal study of Huperzia species used in the traditional medicine of Saraguros in Southern Ecuador; AChE and MAO inhibitory activity. J Ethnopharmacol. 2016;193:546-554 pubmed publisher
    This study concerns seven Huperzia species (Lycopodiaceae), namely H. brevifolia, H. columnaris, H. compacta, H. crassa, H. espinosana, H. tetragona, H...
  25. Long H, Li J, Li Y, Xie D, Peng Q, Li L. Ontogenetic characterization of sporangium and spore of Huperzia serrata: an anti-aging disease fern. Bot Stud. 2016;57:36 pubmed publisher
    b>Huperzia serrata is a medicinal plant used in Traditional Chinese Medicine, which has been used to prevent against aging diseases. It is mainly propagated by spores and grows extremely slowly...
  26. Xu B, Lei L, Zhu X, Zhou Y, Xiao Y. Identification and characterization of L-lysine decarboxylase from Huperzia serrata and its role in the metabolic pathway of lycopodium alkaloid. Phytochemistry. 2017;136:23-30 pubmed publisher
    ..Six cDNAs encoding lysine decarboxylases (LDCs) were cloned from Huperzia serrata by degenerate PCR and rapid amplification of cDNA ends (RACE)...
  27. Wang Z, Liu J, Li H, Yang H. Pharmacological Effects of Active Components of Chinese Herbal Medicine in the Treatment of Alzheimer's Disease: A Review. Am J Chin Med. 2016;44:1525-1541 pubmed
    ..Huperzine A, extracted from Huperzia serrata, exerts a cholinesterase inhibitor effect...
  28. Bunsupa S, Hanada K, Maruyama A, Aoyagi K, Komatsu K, Ueno H, et al. Molecular Evolution and Functional Characterization of a Bifunctional Decarboxylase Involved in Lycopodium Alkaloid Biosynthesis. Plant Physiol. 2016;171:2432-44 pubmed publisher
    ..L/ODC), the first gene involved in LA biosynthesis, from the LA-producing plants Lycopodium clavatum and Huperzia serrata We describe the in vitro and in vivo functional characterization of the L. clavatum L/ODC (LcL/ODC)...
  29. Morita H, Kondo S, Kato R, Wanibuchi K, Noguchi H, Sugio S, et al. Crystallization and preliminary crystallographic analysis of an acridone-producing novel multifunctional type III polyketide synthase from Huperzia serrata. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007;63:576-8 pubmed
    Polyketide synthase 1 (PKS1) from Huperzia serrata is a plant-specific type III polyketide synthase that shows an unusually versatile catalytic potential, producing various aromatic tetraketides, including chalcones, benzophenones, ..
  30. Lin P, Li X, Yuan F, Chen W, Yang M, Xu H. Evaluation of the in vitro and in vivo metabolic pathway and cytochrome P450 inhibition/induction profile of Huperzine A. Biochem Biophys Res Commun. 2016;480:248-253 pubmed publisher
    Huperzine A (HupA), one of the reversible and selective acetylcholinesterase inhibitors derived from Chinese herb Huperzia Serrata, possesses affirmative action of ameliorating cognitive dysfunction of Alzheimer's disease...
  31. Johansen K, Ebild S, Christensen S, Godejohann M, Jaroszewski J. Alkaloid analysis by high-performance liquid chromatography-solid phase extraction-nuclear magnetic resonance: new strategies going beyond the standard. J Chromatogr A. 2012;1270:171-7 pubmed publisher
    ..Alkaloid extracts of Huperzia selago containing complex aliphatic alkaloids and Triclisia patens containing bisbenzylisoquinoline alkaloids ..
  32. Wang H, Tan C, Tan J, Qu S, Chen Y, Li Y, et al. Two new N-oxide Lycopodium alkaloids from Huperzia serrata. Nat Prod Res. 2009;23:1363-6 pubmed publisher
    ..E (1) and N-oxidehuperzine F (2), along with two known alkaloids, huperzines E (3) and F (4), were isolated from Huperzia serrata (Thunb.) Trev. Their structures were elucidated by spectroscopic and chemical transformations.
  33. Liu Y, Zhang Z, Su J, Peng L, Pan L, Wu X, et al. Lycodine-Type Lycopodium Alkaloids from the Whole Plants of Huperzia serrata. Nat Prod Bioprospect. 2017;7:405-411 pubmed publisher
    ..N-methylhuperzine A (4), along with 11 known analogues (5-15), were isolated from the whole plants of club moss Huperzia serrata. The structures of 1-4 were elucidated on the basis of NMR spectroscopic and mass spectrometry data...
  34. Niu Y, Luo H, Chen S, Huang L. [Cloning and bioinformatics analysis of cycloartenol synthase (HcCAS1) gene in Huperzia carinata]. Zhongguo Zhong Yao Za Zhi. 2012;37:1715-9 pubmed
    To clone and sequence the open reading frame of cycloartenol synthase (CAS) from Huperzia carinata. After searching the transcriptome dataset of H. carinata, one unique sequence containing oxide squalene cyclases domain was discovered...
  35. Puiatti M, Borioni J, Vallejo M, Cabrera J, Agnese A, Ortega M, et al. Study of the interaction of Huperzia saururus Lycopodium alkaloids with the acetylcholinesterase enzyme. J Mol Graph Model. 2013;44:136-44 pubmed publisher
    ..the binding modes of three Lycopodium alkaloids (sauroine, 6-hydroxylycopodine and sauroxine; isolated from Huperzia saururus) and huperzine A with the enzyme acetylcholinesterase...
  36. Armijos C, Ponce J, Ramirez J, Gozzini D, Finzi P, Vidari G. An Unprecedented High Content of the Bioactive Flavone Tricin in Huperzia Medicinal Species Used by the Saraguro in Ecuador. Nat Prod Commun. 2016;11:273-4 pubmed
    ..In this paper we describe a reliable UHPLC-UV-ESIMS method for the determination of tricin in Huperzia plants used in the traditional medicine of the Saraguro community living in Southern Ecuador...
  37. Qi B, Liu X, Mo T, Zhu Z, Li J, Wang J, et al. 3,5-Dimethylorsellinic Acid Derived Meroterpenoids from Penicillium chrysogenum MT-12, an Endophytic Fungus Isolated from Huperzia serrata. J Nat Prod. 2017;80:2699-2707 pubmed publisher
    ..acid derived meroterpenoids were isolated from the solid substrate fermentation cultures of a Huperzia serrata endophytic fungus, Penicillium chrysogenum MT-12...
  38. Barón E, Landazábal L, Ballesteros H, Prieto D, Hleap J. [Sporangia ontogeny and sporogenesis of the lycopodium Huperzia brevifolia (Lycopodiaceae) from the high mountains of Colombia]. Rev Biol Trop. 2009;57:1141-52 pubmed
    b>Huperzia brevifolia is one of the dominant species of the genus Huperzia living in paramos and superparamos from the Colombian Andes...
  39. Lin H, Snider B. Synthesis of (±)-7-hydroxylycopodine. Org Lett. 2011;13:1234-7 pubmed publisher
    ..A six step synthesis of (±)-7-hydroxylycopodine has been achieved in 5% overall yield. In the key step, a Prins cyclization of a bicyclic keto alkyne in 60% H(2)SO(4) forms a tricyclic dihydroxy amino ketone. ..
  40. Wu Q, Gu Y. Quantification of huperzine A in Huperzia serrata by HPLC-UV and identification of the major constituents in its alkaloid extracts by HPLC-DAD-MS-MS. J Pharm Biomed Anal. 2006;40:993-8 pubmed
    ..performance liquid chromatography (HPLC) method has been established for the analysis of the major alkaloids in Huperzia serrata, a traditional Chinese medicine (TCM) herb...
  41. Franks P, Farquhar G. The mechanical diversity of stomata and its significance in gas-exchange control. Plant Physiol. 2007;143:78-87 pubmed
    ..Such properties might underlie the success of grasses...
  42. Howes M, Fang R, Houghton P. Effect of Chinese Herbal Medicine on Alzheimer's Disease. Int Rev Neurobiol. 2017;135:29-56 pubmed publisher
    ..g., Salvia miltiorrhiza). Some CHMs (e.g., Ginkgo biloba extract, and huperzine A from Huperzia serrata) show pharmacological activities relevant to AD, and promising effects on cognitive functions in clinical ..
  43. Cuthbertson D, Piljac Zegarac J, Lange B. Validation of a microscale extraction and high-throughput UHPLC-QTOF-MS analysis method for huperzine A in Huperzia. Biomed Chromatogr. 2012;26:1191-5 pubmed publisher
    ..an acetylcholinesterase-inhibiting alkaloid, from as little as 3?mg of tissue homogenate from the clubmoss Huperzia squarrosa (G. Forst.) Trevis with 99.95% recovery...
  44. Ji S, Huo K, Wang J, Pan S. Molecular identification of twelve medicinal plants of Huperziaceae. Am J Chin Med. 2007;35:1061-71 pubmed
    ..The result also can provide information with regard to the use of plant tissue culture and cuttage propagation to solve the problem of the resource depletion of these plants...
  45. Ortega M, Vallejo M, Cabrera J, Perez M, Almiron R, Ramirez O, et al. Huperzia saururus, activity on synaptic transmission in the hippocampus. J Ethnopharmacol. 2006;104:374-8 pubmed
    b>Huperzia saururus (Lam.) Trevis. (Lycopodiaceae) known as cola de quirquincho is used in folk medicine to improve memory...
  46. Yin X, Bai Z, Niu Y, Luo H, Chen S. [Cloning and analysis of squalene synthase (HsSQS1) gene in Huperzia serrata]. Yao Xue Xue Bao. 2012;47:1079-84 pubmed
    ..This study focused on cloning and analysis of Huperzia serrata SQS (HsSQS1) gene...
  47. Oluwafemi A, Okanla E, Camps P, Muñoz Torrerob D, Mackey Z, Chiang P, et al. Evaluation of cryptolepine and huperzine derivatives as lead compounds towards new agents for the treatment of human African trypanosomiasis. Nat Prod Commun. 2009;4:193-8 pubmed
    ..6 days compared with 8.4 days for untreated controls. In addition, four huperzine derivatives (9-12) were shown to have in vitro antitrypanosomal activities with IC50 values ranging from 303-377 nM...
  48. Wang Z, Zhou J, Tang X. Huperzine B protects rat pheochromocytoma cells against oxygen-glucose deprivation-induced injury. Acta Pharmacol Sin. 2002;23:1193-8 pubmed
    ..To test the ability of huperzine B (HupB) to alleviate injury from oxygen-glucose deprivation (OGD) in the rat pheochromocytoma line PC12 cells...
  49. Wu T, Chen C, Chen C, Jinn T. Traditional Chinese medicines and Alzheimer's disease. Taiwan J Obstet Gynecol. 2011;50:131-5 pubmed publisher
    ..In this review, we summarize the latest research progress on six herbs for AD therapy-Huperzia serrata, Amaryllidaceae family, Ginkgo biloba, Uncaria rhynchophylla, Polygala tenuifolia, and Salvia officinalis-..
  50. Zhang Y, Xie J, Chen W, Zhou T, Lu W. Development of a sensitive high-performance liquid chromatographic method with simple extraction for simultaneous determination of huperzine A and huperzine B in the species containing lycopodium alkaloids. J AOAC Int. 2009;92:1060-3 pubmed
    ..simple extraction was developed for simultaneous determination of huperzine A (HupA) and huperzine B (HupB) in Huperzia serrata, H. crispata, H. miyoshiana, and Lycopodiastrum casuarinoides...
  51. Orhan I, Orhan G, Gurkas E. An overview on natural cholinesterase inhibitors--a multi-targeted drug class--and their mass production. Mini Rev Med Chem. 2011;11:836-42 pubmed
    ..is the latest anticholinesterase drug used against AD. Huperzine A, isolated from Huperzia serrata (Thunb.) Trev...
  52. Vallejo M, Loyola S, Contreras D, Ugarte G, Cifuente D, Ortega G, et al. A new semisynthetic derivative of sauroine induces LTP in hippocampal slices and improves learning performance in the Morris Water Maze. J Neurochem. 2014;129:864-76 pubmed publisher
    Two semisynthetic acetyl derivatives of the alkaloid sauroine from Huperzia saururus, monoacetyl sauroine, and diacetyl sauroine (DAS) were obtained and their chemical structures were analyzed by NMR...
  53. Guo B, Xu L, Wei Y, Liu C. [Research advances of Huperzia serrata (Thunb.) Trev]. Zhongguo Zhong Yao Za Zhi. 2009;34:2018-23 pubmed
    Qiancengta, a traditional Chinese medicine produced from the whole plant of the club moss Huperzia serrata, has been used for a long history in China for treatment of a number of ailments, including contusions, strains, swellings, ..
  54. Ying Y, Shan W, Zhang L, Zhan Z. Ceriponols A-K, tremulane sesquitepenes from Ceriporia lacerate HS-ZJUT-C13A, a fungal endophyte of Huperzia serrata. Phytochemistry. 2013;95:360-7 pubmed publisher
    ..isolated from the cultures of Ceriporia lacerate, a fungal endophyte residing in the stems of the medicinal plant Huperzia serrata. Among these isolates, ceriponol B possessed an unprecedent 12-nortremulane skeleton...
  55. Ishiuchi K, Park J, Long R, Gang D. Production of huperzine A and other Lycopodium alkaloids in Huperzia species grown under controlled conditions and in vitro. Phytochemistry. 2013;91:208-19 pubmed publisher
    ..A (HupA), an anti-Alzheimer's disease (AD) drug candidate from the traditional Chinese medicine Qian Ceng Ta (Huperzia serrata), in samples of 11 Huperzia genus plants. The highest content of HupA was found in Huperzia pinifolia...
  56. Shan S, Luo J, Pan K, Zou H, Kong L. Rapid screening and identification of lycodine-type alkaloids in Lycopodiaceae and Huperziaceae plants by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Biomed Chromatogr. 2016;30:1861-1872 pubmed publisher
    ..The lycodine-type alkaloids were detected successfully from Lycopodiastrum casuarinoides, Huperzia serrata and Phlegmarirus carinatus in seven plants of the Lycopodiaceae and Huperziaceae families, based on the ..
  57. Yang Y, Wang Z, Wu J, Chen Y. Chemical Constituents of Plants from the Genus Phlegmariurus. Chem Biodivers. 2016;13:269-74 pubmed publisher
    ..These compounds show potent bioactivities, such as acetylcholinesterase inhibitory and cytotoxic activities...
  58. Li Y, Jiang X, Lan K, Wang L. Simple determination of huperzine A in human plasma by liquid chromatographic-tandem mass spectrometric method. Biomed Chromatogr. 2007;21:15-20 pubmed
    ..064 ng/mL. The average recovery for huperzine A was 83.4% from plasma. The analytical sensitivity and accuracy of this assay is adequate for characterization of huperzine A in human plasma...
  59. Shao H, Zhang L, Lv H, Zhou J, Hu Z, Li W. [The utility of trnH-psbA gene for phylogenetic analysis of Huperziaceae and plant barcoding]. Zhong Yao Cai. 2010;33:18-21 pubmed
    ..The purpose of study was to discover the phylogenetic relations and plant barcoding of 17 plants from Huperziaceae...
  60. Tang L, Wang R, Tang X. Effects of huperzine A on secretion of nerve growth factor in cultured rat cortical astrocytes and neurite outgrowth in rat PC12 cells. Acta Pharmacol Sin. 2005;26:673-8 pubmed
    ..To study the effects of huperzine A (HupA) on neuritogenic activity and the expression of nerve growth factor (NGF)...
  61. Yuan S, Zhao Y. [A novel phlegmariurine type alkaloid from Huperzia serrata (Thunb.) Trev]. Yao Xue Xue Bao. 2003;38:596-8 pubmed
    To study the alkaloid constituents of Huperzia serrata (Thunb.) Trev..
  62. Yang M, You W, Wu S, Fan Z, Xu B, Zhu M, et al. Global transcriptome analysis of Huperzia serrata and identification of critical genes involved in the biosynthesis of huperzine A. BMC Genomics. 2017;18:245 pubmed publisher
    b>Huperzia serrata (H. serrata) is an economically important traditional Chinese herb with the notably medicinal value. As a representative member of the Lycopodiaceae family, the H...
  63. Vallejo M, Ortega M, Cabrera J, Carlini V, de Barioglio S, Almirón R, et al. Sauroine, an alkaloid from Huperzia saururus with activity in wistar rats in electrophysiological and behavioral assays related to memory retention. J Nat Prod. 2009;72:156-8 pubmed publisher
    The present study describes the effects of sauroine (1), the main alkaloid obtained from Huperzia saururus, on memory retention and learning...
  64. Gao X, Zheng C, Yang L, Tang X, Zhang H. Huperzine A protects isolated rat brain mitochondria against beta-amyloid peptide. Free Radic Biol Med. 2009;46:1454-62 pubmed publisher
    ..These direct effects on mitochondria further extend the noncholinergic functions of HupA...
  65. García M, Poser G, Apel M, Tlatilpa R, Mendoza Ruiz A, Villarreal M, et al. Anticholinesterase activity and identification of huperzine A in three Mexican lycopods: Huperzia cuernavacensis, Huperzia dichotoma and Huperzia linifolia (Lycopodiaceae). Pak J Pharm Sci. 2017;30:235-239 pubmed
    Huperzine A (Hup A), the alkaloid produced by the Chinese medicinal plant Huperzia serrata, has been documented to be a promising agent for the treatment of Alzheimer's disease due to its potent acetylcholinesterase inhibitory (AChEI) ..
  66. Yang Q, Kou X, Fugal K, McLaughlin J. Determination of huperzine A in formulated products by reversed-phase-liquid chromatography using diode array and electrospray ionization mass spectrometric detection. Phytomedicine. 2003;10:200-5 pubmed
    ..8-11.6 microg/ml. Overall recovery of huperzine A was 103.9% +/- 1.8 (mean +/- SD). Relative standard deviations for intra- and interday precision were < 2%...
  67. Toribio A, Delannay E, Richard B, Plé K, Zèches Hanrot M, Nuzillard J, et al. Preparative isolation of huperzines A and B from Huperzia serrata by displacement centrifugal partition chromatography. J Chromatogr A. 2007;1140:101-6 pubmed
    ..the two acetylcholinesterase inhibitors huperzines A and B from a crude alkaloid extract of the club moss Huperzia serrata...
  68. Sun Y, Chen H, Sun H, Ai M, Su J, Yu L, et al. Naumannella huperziae sp. nov., an endophytic actinobacterium isolated from Huperzia serrata (Thunb.). Int J Syst Evol Microbiol. 2017;67:1867-1872 pubmed publisher
    ..actinobacterium, designated strain CPCC 204135T, was isolated from a surface-sterilized medicinal plant, Huperzia serrata (Thunb.), collected from Sichuan Province, south-west China...
  69. Yang Y, Qu S, Xiao K, Jiang S, Tan J, Tan C, et al. Lycopodium alkaloids from Huperzia serrata. J Asian Nat Prod Res. 2010;12:1005-9 pubmed publisher
    ..alkaloid, 6?-hydroxy-5,15-oxide-lycopodane (1), and seven known alkaloids were isolated from the whole plants of Huperzia serrata. Their structures were elucidated by means of spectroscopic methods...
  70. Wang Y, Lai Z, Li X, Yan R, Zhang Z, Yang H, et al. Isolation, diversity and acetylcholinesterase inhibitory activity of the culturable endophytic fungi harboured in Huperzia serrata from Jinggang Mountain, China. World J Microbiol Biotechnol. 2016;32:20 pubmed publisher
    b>Huperzia serrata has many important medicinal properties with proven pharmacological potential. Some of these properties may be mediated by its endophytic fungi...
  71. Perry E, Howes M. Medicinal plants and dementia therapy: herbal hopes for brain aging?. CNS Neurosci Ther. 2011;17:683-98 pubmed publisher
  72. Ji S, Pan S, Wang J, Huo K. [Phylogeny relationship and molecular identification of ten Huperzia species (Huperziaceae) based on matK gene sequences]. Zhongguo Zhong Yao Za Zhi. 2007;32:1971-5 pubmed
    To study the phylogeny relationship and molecular identification of 10 species from Huperzia (Huperziaceae) based on matK gene sequences data.
  73. Vallejo M, Dimmer J, Ortega M, Cabrera J, Agnese A. Amino acid content and acetylcholinesterase inhibition of Huperzia saururus infusion and decoction. Pharm Biol. 2013;51:1341-5 pubmed publisher
    CONTEXT. Huperzia saururus (Lam.) Trevis. (Lycopodiaceae), an autochthonous plant species in Argentina, is used as a memory improver in traditional medicine...
  74. Wang L, Lv H, Zhang L, Hua H, Wang J, Hu Z, et al. [Screening of endophytic fungi from Huperzia serrata for acetylcholinesterase inhibitory activity and its taxonomic identification]. Zhongguo Zhong Yao Za Zhi. 2012;37:3701-5 pubmed
    To screen out fungus strains with acetylcholinesterase inhibitory activity from Huperzia serrata.
  75. Leake J, Cameron D, Beerling D. Fungal fidelity in the myco-heterotroph-to-autotroph life cycle of Lycopodiaceae: a case of parental nurture?. New Phytol. 2008;177:572-6 pubmed publisher
  76. Li N, Chen J, Zhu D. [Mechanism of effects of soil microbes on cuttings rooting of Huperzia serrata]. Zhongguo Zhong Yao Za Zhi. 2007;32:2478-81 pubmed
    To study the effects of soil microbes of habitats on the cuttings rooting of Huperzia serrata and its mechanism.
  77. Tan C, Chen G, Ma X, Jiang S, Zhu D. Three new phlegmariurine B type lycopodium alkaloids from Huperzia serrata. J Asian Nat Prod Res. 2002;4:227-31 pubmed
    ..2), 2-oxoyphlegmariurine B (3) and 11-oxophlegmariurine B (4), were isolated from the CHCl3 fraction of total alkaloids of whole plant of the Chinese medicinal herb Huperzia serrata. Their structures were elucidated by spectral analysis.
  78. Izzo A, Capasso F. Herbal medicines to treat Alzheimer's disease. Trends Pharmacol Sci. 2007;28:47-8 pubmed
  79. Yang Y, Yang X, Xu Y, Tai Z, Dong L, Ding Z. [Two diterpenoids from herbs of Huperzia serrata]. Zhongguo Zhong Yao Za Zhi. 2009;34:987-9 pubmed
    To investigate the constituents from Huperzia serrata.
  80. Konrath E, Ortega M, de Loreto Bordignon S, Apel M, Henriques A, Cabrera J. Alkaloid profiling and anticholinesterase activity of South American Lycopodiaceae species. J Enzyme Inhib Med Chem. 2013;28:218-22 pubmed publisher
    The alkaloid extracts of four Huperzia and one Lycopodiella species, from Brazilian habitats, were tested for their in vitro anticholinesterase activities. IC(50) values showed a potent acetylcholinesterase inhibition for H. reflexa (0...
  81. Zhang H, Liang H, Kuang P, Yuan Q, Wang Y. Simultaneously preparative purification of Huperzine A and Huperzine B from Huperzia serrata by macroporous resin and preparative high performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2012;904:65-72 pubmed publisher
    ..utilizing the limited plant resources, a quick and low cost method to separate and purify HupA and HupB from Huperzia serrata (Thunb. ex Murray) was established in this paper...
  82. Konrath E, Neves B, Passos C, Lunardi P, Ortega M, Cabrera J, et al. Huperzia quadrifariata and Huperzia reflexa alkaloids inhibit acetylcholinesterase activity in vivo in mice brain. Phytomedicine. 2012;19:1321-4 pubmed publisher
    Huperzine A, a Lycopodium alkaloid produced by Chinese folk herb Huperzia serrata (Lycopodiaceae), has been shown to be a promising agent for the treatment of Alzheimer's disease due to its potent acetylcholinesterase (AChE) activity, as ..
  83. Staerk D, Larsen J, Larsen L, Olafsdottir E, Witt M, Jaroszewski J. Selagoline, a new alkaloid from Huperzia selago. Nat Prod Res. 2004;18:197-203 pubmed
    A new natural product, named selagoline, and two known alkaloids, huperzine A and serratidine, were isolated from Huperzia selago (Lycopodiaceae) collected in Iceland...
  84. Higgins K, Arnold A, Miadlikowska J, Sarvate S, Lutzoni F. Phylogenetic relationships, host affinity, and geographic structure of boreal and arctic endophytes from three major plant lineages. Mol Phylogenet Evol. 2007;42:543-55 pubmed
    ..We surveyed endophytic Ascomycota from healthy photosynthetic tissues of three plant species (Huperzia selago, Picea mariana, and Dryas integrifolia, representing lycophytes, conifers, and angiosperms, respectively) ..
  85. Winther J, Friedman W. Arbuscular mycorrhizal associations in Lycopodiaceae. New Phytol. 2008;177:790-801 pubmed
    ..the molecular and phylogenetic identity of fungi involved in arbuscular mycorrhizal (AM) associations in extant Huperzia and Lycopodium (Lycopodiaceae)...
  86. Vallejo M, Ortega M, Cabrera J, Carlini V, de Barioglio S, Agnese A. Huperzia saururus increases memory retention in rats. J Ethnopharmacol. 2007;111:685-7 pubmed
    b>Huperzia saururus is reported in Argentinean popular medicine as a memory improver. Chemical studies have shown that the main constituents of the species are Lycopodium alkaloids...