cephalotaxus

Summary

Summary: A plant genus of the family TAXACEAE, order Pinales, class Pinopsida, division TRACHEOPHYTA. Members contain homoharringtonine.

Top Publications

  1. Wang L, Su H, Yang S, Won S, Lin C. New alkaloids and a tetraflavonoid from Cephalotaxus wilsoniana. J Nat Prod. 2004;67:1182-5 pubmed
    ..2), and a new stereoisomer of desmethylcephalotaxinone (3) have been isolated from the leaves and heartwood of Cephalotaxus wilsoniana, respectively. The structures were elucidated by spectroscopic methods...
  2. Lee M, Lim S, Yang H, Sung S, Lee H, Park M, et al. Osteoblast differentiation stimulating activity of biflavonoids from Cephalotaxus koreana. Bioorg Med Chem Lett. 2006;16:2850-4 pubmed
    ..4), sciadopitysin (5), and 7,4',7'',4'''-O-methyl-amentoflavone (6), were isolated from the EtOAc fraction of Cephalotaxus koreana Nakai (Cephalotaxaceae) by bioactivity-guided fractionation technique using primary cultures of mouse ..
  3. Langenfeld A, Prado S, Nay B, Cruaud C, Lacoste S, Bury E, et al. Geographic locality greatly influences fungal endophyte communities in Cephalotaxus harringtonia. Fungal Biol. 2013;117:124-36 pubmed publisher
    ..We examined foliar and stem endophytes of Cephalotaxus harringtonia, within its natural range in Japan and outside its natural range in France to study the effect of ..
  4. Li W, Dai R, Yu Y, Li L, Wu C, Luan W, et al. Antihyperglycemic effect of Cephalotaxus sinensis leaves and GLUT-4 translocation facilitating activity of its flavonoid constituents. Biol Pharm Bull. 2007;30:1123-9 pubmed
    The objectives of this study were to investigate the antihyperglycemic effect of Cephalotaxus sinensis leaves and to identify the active components...
  5. Bae K, Jin W, Thuong P, Min B, Na M, Lee Y, et al. A new flavonoid glycoside from the leaf of Cephalotaxus koreana. Fitoterapia. 2007;78:409-13 pubmed
    ..1), along with four known flavonol glycosides (2-5), were isolated from the leaf of Cephalotaxus koreana...
  6. Evanno L, Jossang A, Nguyen Pouplin J, Delaroche D, Herson P, Seuleiman M, et al. Further studies of the norditerpene (+)-harringtonolide isolated from Cephalotaxus harringtonia var. drupacea: absolute configuration, cytotoxic and antifungal activities. Planta Med. 2008;74:870-2 pubmed publisher
    Harringtonolide (= hainanolide) is a complex polycyclic fused norditerpene isolated from CEPHALOTAXUS HARRINGTONIA var. DRUPACEA...
  7. Moirangthem D, Talukdar N, Kasoju N, Bora U. Antioxidant, antibacterial, cytotoxic, and apoptotic activity of stem bark extracts of Cephalotaxus griffithii Hook. f. BMC Complement Altern Med. 2012;12:30 pubmed publisher
    b>Cephalotaxus spp. are known to possess various therapeutic potentials. Cephalotaxus griffithii, however, has not been evaluated for its biological potential...
  8. Bocar M, Jossang A, Bodo B. New alkaloids from Cephalotaxus fortunei. J Nat Prod. 2003;66:152-4 pubmed
    Four new cephalotaxus alkaloids, cephalotaxine alpha-N-oxide (1), cephalotaxine beta-N-oxide (2), 11-beta-hydroxycephalotaxine beta-N-oxide (3), and isocephalotaxine (4), were isolated, together with several known alkaloids from an EtOAc ..
  9. Abdelkafi H, Nay B. Natural products from Cephalotaxus sp.: chemical diversity and synthetic aspects. Nat Prod Rep. 2012;29:845-69 pubmed publisher
    The Cephalotaxus genus belongs to the Cephalotaxaceae family of conifers...

More Information

Publications54

  1. Li W, Deng Y, Dai R, Yu Y, Saeed M, Li L, et al. Chromatographic fingerprint analysis of Cephalotaxus sinensis from various sources by high-performance liquid chromatography-diodearray detection-electrospray ionization-tandem mass spectrometry. J Pharm Biomed Anal. 2007;45:38-46 pubmed
    ..A simple, rapid and valid fingerprint method has been first carried out for the quality control of Cephalotaxus sinensis by using high-performance liquid chromatography (HPLC) coupled with photodiode array detection (DAD) ..
  2. Efferth T, Sauerbrey A, Halatsch M, Ross D, Gebhart E. Molecular modes of action of cephalotaxine and homoharringtonine from the coniferous tree Cephalotaxus hainanensis in human tumor cell lines. Naunyn Schmiedebergs Arch Pharmacol. 2003;367:56-67 pubmed
    ..Homoharringtonine (HHT) is an ester of cephalotaxine (CET), both of which derive from the Chinese coniferous tree Cephalotaxus hainanensis...
  3. Ni D, Ho D, Vijjeswarapu M, Felix E, Rhea P, Newman R. Metabolism of homoharringtonine, a cytotoxic component of the evergreen plant Cephalotaxus harringtonia. J Exp Ther Oncol. 2003;3:47-52 pubmed
    Homoharringtonine (HHT), first isolated from the Chinese evergreen Cephalotaxus harringtonia, has been demonstrated to have a broad antitumor activity in rodents and antileukemic effects in humans...
  4. Pan H, Guo Y, Su Y, Wang T. Development of microsatellite loci for Cephalotaxus oliveri (Cephalotaxaceae) and cross-amplification in Cephalotaxus. Am J Bot. 2011;98:e229-32 pubmed publisher
    Microsatellite loci were developed for Cephalotaxus oliveri, an endemic and endangered conifer in China, which will allow assessment of the levels of genetic diversity and a means to understand the genetic consequences of habitat ..
  5. Yi X, Gao L, Wang B, Su Y, Wang T. The complete chloroplast genome sequence of Cephalotaxus oliveri (Cephalotaxaceae): evolutionary comparison of cephalotaxus chloroplast DNAs and insights into the loss of inverted repeat copies in gymnosperms. Genome Biol Evol. 2013;5:688-98 pubmed publisher
    We have determined the complete chloroplast (cp) genome sequence of Cephalotaxus oliveri. The genome is 134,337 bp in length, encodes 113 genes, and lacks inverted repeat (IR) regions...
  6. Fan Y, Xu J, Liu H, Gan L, Ding J, Yue J. Cephanolides A-J, Cephalotane-Type Diterpenoids from Cephalotaxus sinensis. J Nat Prod. 2017;: pubmed publisher
    ..diterpenoids, cephanolides A-J (1-10), and two known analogues were isolated and characterized from Cephalotaxus sinensis...
  7. Elpe C, Knopf P, Stützel T, Schulz C. Diversity and evolution of leaf anatomical characters in Taxaceae s.l.-fluorescence microscopy reveals new delimitating characters. J Plant Res. 2018;131:125-141 pubmed publisher
    Taxaceae s.l. comprise six genera (including Cephalotaxus) and about 35 species; The present study aims to give new insights into the evolution of this family, especially into the phylogenetic position of Cephalotaxus...
  8. Hu X, Li W, Yuan M, Li C, Liu S, Jiang C, et al. Homoharringtonine production by endophytic fungus isolated from Cephalotaxus hainanensis Li. World J Microbiol Biotechnol. 2016;32:110 pubmed publisher
    Homoharringtonine (HHT), a natural plant alkaloid derived from Cephalotaxus, has demonstrated to have a broad antitumor activity and efficacy in treating human chronic myeloid leukemia...
  9. Ni L, Zhong X, Cai J, Bao M, Zhang B, Wu J, et al. Five New Alkaloids from Cephalotaxus lanceolata and C. fortunei var. alpina. Nat Prod Bioprospect. 2016;6:149-54 pubmed publisher
    Five new alkaloids (1-5) were isolated from the leaves and twigs of Cephalotaxus lanceolata and C. fortunei var. alpina along with 24 known alkaloids...
  10. Pirone Davies C, Prior N, von Aderkas P, Smith D, Hardie D, Friedman W, et al. Insights from the pollination drop proteome and the ovule transcriptome of Cephalotaxus at the time of pollination drop production. Ann Bot. 2016;117:973-84 pubmed publisher
    ..gymnosperm pollination biology, the pollination drop proteomes of pollination drops from two species of Cephalotaxus have been characterized and an ovular transcriptome for C. sinensis has been assembled...
  11. Xu J, Fan Y, Gan L, Zhou Y, Li J, Yue J. Cephalotanins A-D, Four Norditerpenoids Represent Three Highly Rigid Carbon Skeletons from Cephalotaxus sinensis. Chemistry. 2016;22:14648-54 pubmed publisher
    ..A-D (1-4) representing three unprecedented carbon skeletons with highly rigid ring systems, were isolated from Cephalotaxus sinensis and structurally characterized by a combination of various methods...
  12. Pérard Viret J, Quteishat L, Alsalim R, Royer J, Dumas F. Cephalotaxus Alkaloids. Alkaloids Chem Biol. 2017;78:205-352 pubmed publisher
    b>Cephalotaxus alkaloids represent a family of plant secondary metabolites known for 60 years. Significant activity against leukemia in mice was demonstrated for extracts of Cephalotaxus...
  13. Cao W, Liu Y, Zhang R, Zhang B, Wang T, Zhu X, et al. Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells. Sci Rep. 2015;5:8477 pubmed publisher
    ..Here we investigated the antitumor effect of homoharringtonine (HHT), a natural compound extracted from Cephalotaxus harringtonia, on Gefitinib-resistant NSCLC cell lines in vitro and in vivo...
  14. Vallet M, Vanbellingen Q, Fu T, Le Caer J, Della Negra S, Touboul D, et al. An Integrative Approach to Decipher the Chemical Antagonism between the Competing Endophytes Paraconiothyrium variabile and Bacillus subtilis. J Nat Prod. 2017;80:2863-2873 pubmed publisher
    ..variabile and the bacterium Bacillus subtilis, which were isolated as endophytes from the conifer Cephalotaxus harringtonia and are characterized by a strong and mutual antibiosis...
  15. Sakamoto S, Yusakul G, Tsuneura Y, Putalun W, Usui K, Miyamoto T, et al. Sodium periodate-mediated conjugation of harringtonine enabling the production of a highly specific monoclonal antibody, and the development of a sensitive quantitative analysis method. Analyst. 2017;142:1140-1148 pubmed publisher
    Harringtonine (HT) is a promising natural product that is mainly isolated from plants of the genus Cephalotaxus. Due to its remarkable antileukemic activities, HT has been utilized clinically in China for the treatment of acute ..
  16. Geng S, Yao H, Weng J, Tong J, Huang X, Wu P, et al. Effects of the combination of decitabine and homoharringtonine in SKM-1 and Kg-1a cells. Leuk Res. 2016;44:17-24 pubmed publisher
    ..Homoharringtonine (HHT), an alkaloid from Chinese natural plants and Cephalotaxus, has demonstrated potential for leukemia treatment...
  17. Sakamoto S, Yusakul G, Nuntawong P, Kitisripanya T, Putalun W, Miyamoto T, et al. Development of an indirect competitive immunochromatographic strip test for rapid detection and determination of anticancer drug, harringtonine. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1048:150-154 pubmed publisher
    Harringtonine (HT) is a natural compound, which is mainly produced by the genus Cephalotaxus, and has been clinically utilized in China for the treatment of acute leukemia and lymphoma...
  18. Zheng C, Sun P, Jin G, Qin L. Sesquiterpenoids from Trichoderma atroviride, an endophytic fungus in Cephalotaxus fortunei. Fitoterapia. 2011;82:1035-8 pubmed publisher
    ..S361), an endophytic fungal strain residing in the bark of Cephalotaxus fortunei...
  19. Zhang W, Zhou T. [Studies on urinary metabolites of HH07A, a derivative of hainanensine, in rats]. Yao Xue Xue Bao. 1998;33:212-6 pubmed
    ..The mass spectra of HH07A and its four metabolites as well as their derivatives were presented. The structures of the metabolites were proposed and the in vivo metabolic pathway of HH07A was given in Figure 6...
  20. Chen G, Dai H, Sha Y, Pei Y. Two new compounds from the endophytic fungus Colletotrichum sp. L10 of Cephalotaxus hainanensis. J Asian Nat Prod Res. 2011;13:1042-6 pubmed publisher
    ..pyroglutamate (1) and 2,2'-(1,1'-methylenebis(1H-indole-3,1-diyl))diethanol (2), were isolated from the endophytic fungus of Cephalotaxus hainanensis. Their structures were determined by means of chemical and spectroscopic analysis.
  21. Dai W, Dai H, Wu J, Liu J, Mei W. A new 5-acyl-2-methylpyrrole from the endophytic fungus S20 of Cephalotaxus hainanensis. Nat Prod Commun. 2009;4:1489-90 pubmed
    A new 5-acyl-2-methylpyrrole, isolated from the endophytic fungus S20 of Cephalotaxus hainanensis, was elucidated as 1-(5-methyl-1H-pyrrol-2-yl)-2-((2S*,3R*)-3-((E)-prop-1-enyl)oxiran-2-yl)ethanone (1) on the basis of spectroscopic ..
  22. Kuo Y, Hwang S, Yang Kuo L, Lee Y, Li S, Shen Y. A novel cytotoxic C-methylated biflavone, taiwanhomoflavone-B from the twigs of Cephalotaxus wilsoniana. Chem Pharm Bull (Tokyo). 2002;50:1607-8 pubmed
    ..6-C-methylnaringenin and apigenin-7-O-beta-glucoside were isolated from an ethanolic extract of Cephalotaxus wilsoniana. The structure of 1 was elucidated on the basis of spectroscopic analysis...
  23. Romero M, Serrano M, Efferth T, Alvarez M, Marin J. Effect of cantharidin, cephalotaxine and homoharringtonine on "in vitro" models of hepatitis B virus (HBV) and bovine viral diarrhoea virus (BVDV) replication. Planta Med. 2007;73:552-8 pubmed
  24. Chen J, Xiao Y, Di P, Yu X, Chen W, Zhang L. Molecular cloning and characterization of a 2C-methyl-D: -erythritol 2,4-cyclodiphosphate synthase gene from Cephalotaxus harringtonia. Mol Biol Rep. 2009;36:1749-56 pubmed publisher
    ..DQ415658) was isolated by rapid amplification of cDNA ends (RACE) for the first time from Cephalotaxus harringtonia...
  25. Lu X, Chen G, Hua H, Dai H, Mei W, Xu Y, et al. Aromatic compounds from endophytic fungus Colletotrichum sp. L10 of Cephalotaxus hainanensis Li. Fitoterapia. 2012;83:737-41 pubmed publisher
    Six aromatic compounds were isolated from the endophytic fungus Colletotrichum sp. of Cephalotaxus hainanensis Li [Cephalotaxus mannii Hook. f.]. Their structures were determined on the basis of chemical and spectroscopic methods...
  26. Mei W, Chen P, Wang H, Huang J, Dai H. Two new sesquiterpenes from endophytic fungus S49 of Cephalotaxus hainanensis. J Asian Nat Prod Res. 2010;12:582-5 pubmed publisher
    ..10,11,12-guaianetriol (1) and 1,10,11,12-guaianetetrol (2), were isolated from endophytic fungus S49 of Cephalotaxus hainanensis Li. Their structures were determined based on HR-ESI-MS and spectroscopic techniques (1D and 2D NMR)...
  27. Meng L, Geng Z, Yin J, Wang H, Ji P. [Chemical properties and enzyme activities of rhizosphere and non-rhizosphere soils under six Chinese herbal medicines on Mt. Taibai of Qinling Mountains, Northwest China]. Ying Yong Sheng Tai Xue Bao. 2012;23:2685-92 pubmed
    ..and non-rhizosphere soils in different habitats of six Chinese herbal medicines, including Pyrola decorata, Cephalotaxus fortunei, Polygonatum odoratum, Potentilla glabra, Polygonum viviparum, and Potentilla fruticosa, on the Mt...
  28. Politi M, Braca A, De Tommasi N, Morelli I, Manunta A, Battinelli L, et al. Antimicrobial diterpenes from the seeds of Cephalotaxus harringtonia var. drupacea. Planta Med. 2003;69:468-70 pubmed
    Six diterpenes, including two new natural products, were isolated from the seeds of Cephalotaxus harringtonia...
  29. Luo C, Tang J, Wang Y. Homoharringtonine: a new treatment option for myeloid leukemia. Hematology. 2004;9:259-70 pubmed
    HHT, one of the alkaloids from a Chinese natural plant, Cephalotaxus, has shown its potential in leukemia treatment...
  30. Park G, Kim S, Song Y. Ester alkaloids from Cephalotaxus interfere with the 2'3'-cGAMP-induced type I interferon pathway in vitro. PLoS ONE. 2017;12:e0182701 pubmed publisher
    ..Notably, 70% ethanol extract of Cephalotaxus koreana specifically down-regulated STING-induced, but not TBK1- or IRF3-induced, IFN-ß promoter activity...
  31. Li Y, Zhu J, Ding B. Homoharringtonine is an effective therapy for patients with polycythemia vera or essential thrombocythemia who have failed or were intolerant to hydroxycarbamide or interferon-? therapy. Int J Clin Oncol. 2013;18:922-6 pubmed publisher
    ..Homoharringtonine (HHT), a valid drug for treating chronic myelogenous leukemia, has shown some effect on leukemic stem cells. The aim of this study was to observe the effect of HHT on patients with high-risk PV and ET...
  32. Amand S, Langenfeld A, Blond A, Dupont J, Nay B, Prado S. Guaiane sesquiterpenes from Biscogniauxia nummularia featuring potent antigerminative activity. J Nat Prod. 2012;75:798-801 pubmed publisher
    ..This fungus, which was isolated as an endophyte from the plum yew Cephalotaxus harringtonia, is also suspected of being a pathogen...
  33. Lu X, Xu N, Dai H, Mei W, Yang Z, Pei Y. Three new compounds from endophytic fungus L10 of Cephalotaxus hainanensis. J Asian Nat Prod Res. 2009;11:397-400 pubmed publisher
    ..along with the two known compounds, nectriapyrone (4) and wermopyrone (5), have been isolated from the endophytic fungus of Cephalotaxus hainanensis. Their structures were determined on the basis of chemical and spectroscopic methods.
  34. Liu Z, Du Q, Wang K, Xiu L, Song G. Completed preparative separation of alkaloids from Cephaltaxus fortunine by step-pH-gradient high-speed counter-current chromatography. J Chromatogr A. 2009;1216:4663-7 pubmed publisher
    Cephalotaxine-type alkaloids are the anti-cancer components in twigs, leaves, roots and seeds of Cephalotaxus fortunine. It is very important to use the limited resource by finding an efficient purification technology of the alkaloids...
  35. Xu X, Zhang W, Yao C, Cao X, Xue S. [Quantitative analysis of hinokiol from cell suspension cultures of Cephalotaxus fortunei]. Se Pu. 2011;29:567-70 pubmed
    ..the separation of secondary metabolites and quantitative analysis of hinokiol from cell suspension cultures of Cephalotaxus fortunei...
  36. Cisowski W, Mazol I, Gleńsk M. Investigation of the essential oils from three Cephalotaxus species. Acta Pol Pharm. 2005;62:461-3 pubmed
    Essential oils from leaves of Cephalotaxus fortunei Hook., Cephalotaxus haningtonia K. Koch., Cephalotaxus sinensis Li. and variety Cephalotaxus harringtonia var. drupacea Koidz. underwent qualitative and quantitative analysis...
  37. Yoon K, Jeong D, Hwang Y, Ryu J, Kim J. Inhibitors of osteoclast differentiation from Cephalotaxus koreana. J Nat Prod. 2007;70:2029-32 pubmed
    ..4), and a new dibenzylbutyrolactone lignan glycoside ( 5) were isolated from the aerial parts of Cephalotaxus koreana Nakai, along with 19 known flavonoids...
  38. Hu Y, Zhu J, Jiang B, Yu R. [Biotransformation of artemisinic acid by cell suspension cultures of Cephalotaxus fortunei and Artemisia annua]. Zhong Yao Cai. 2010;33:662-5 pubmed
    To investigate the biotransformation of artemisinic acid by cell suspension cultures of Cephalotaxus fortunei and Artemisia annua.
  39. Yuan L, Zhang Y, Yu L, Sun C, Wei Y, Liu H, et al. Actinopolymorpha cephalotaxi sp. nov., a novel actinomycete isolated from rhizosphere soil of the plant Cephalotaxus fortunei. Int J Syst Evol Microbiol. 2010;60:51-4 pubmed publisher
    An actinomycete, strain I06-2230(T), was isolated from rhizosphere soil of the plant Cephalotaxus fortunei, collected from Yunnan province, south China...
  40. Taniguchi T, Yokoyama S, Ishibashi H. Asymmetric total synthesis and revised structure of cephalezomine H. J Org Chem. 2009;74:7592-4 pubmed publisher
    A revised structure of cephalezomine H, Cephalotaxus alkaloids, is presented. The originally assigned and revised structures of cephalezomine H were synthesized from the key intermediate for the synthesis of (-)-cephalotaxine.
  41. Wen Y, Meyer S, Masler E, Zhang F, Liao J, Wei X, et al. Nematotoxicity of drupacine and a Cephalotaxus alkaloid preparation against the plant-parasitic nematodes Meloidogyne incognita and Bursaphelenchus xylophilus. Pest Manag Sci. 2013;69:1026-33 pubmed publisher
    Species of Cephalotaxus (the plum yews) produce nematotoxic compounds of unknown identity...
  42. Lassnig E, Heibl C, Punzengruber C, Eber B. ECG of a "dying heart" in a young woman--a case of yew poisoning. Int J Cardiol. 2013;167:e71-3 pubmed publisher
  43. He Y, Shen Y, Li B, Lu L, Tian J, Zhang W. Alkaloids from Cephalotaxus lanceolata and their cytotoxicities. Chem Biodivers. 2013;10:584-95 pubmed publisher
    A phytochemical investigation of the branches and leaves of Cephalotaxus lanceolata resulted in the isolation of three new cephalotaxus alkaloids, cephalancetines A, B, and D (1, 2, and 4, resp...
  44. Dai W, Wu J, Han Z, Mei W, Dai H. Metabolites from endophytic fungus S20 of Cephalotaxus hainanensis. J Asian Nat Prod Res. 2009;11:704-9 pubmed publisher
    ..p-hydroxybenzyl alcohol (4) and indolyl-3-carboxylic acid (5), were isolated from endophytic fungus S20 of Cephalotaxus hainanensis Li...
  45. Combes A, Ndoye I, Bance C, Bruzaud J, Djediat C, Dupont J, et al. Chemical communication between the endophytic fungus Paraconiothyrium variabile and the phytopathogen Fusarium oxysporum. PLoS ONE. 2012;7:e47313 pubmed publisher
    Paraconiothyrium variabile, one of the specific endophytic fungi isolated from the host plant Cephalotaxus harringtonia, possesses the faculty to inhibit the growth of common phytopathogens, thus suggesting a role in its host protection...