soybean proteins


Summary: Proteins which are present in or isolated from SOYBEANS.

Top Publications

  1. Cavazos A, Morales E, Dia V, de Mejia E. Analysis of lunasin in commercial and pilot plant produced soybean products and an improved method of lunasin purification. J Food Sci. 2012;77:C539-45 pubmed publisher
    ..05). It was concluded that all soymilk products analyzed contained lunasin, and a more efficient method to isolate lunasin with higher purity was developed. ..
  2. Smaldini P, Curciarello R, Candreva A, Rey M, Fossati C, Petruccelli S, et al. In vivo evidence of cross-reactivity between cow's milk and soybean proteins in a mouse model of food allergy. Int Arch Allergy Immunol. 2012;158:335-46 pubmed publisher
    ..In this work, we used a food allergy model in BALB/c mice to study the cross-reactivity between cow's milk protein (CMP) and soy proteins (SP)...
  3. Barbosa H, Arruda S, Azevedo R, Arruda M. New insights on proteomics of transgenic soybean seeds: evaluation of differential expressions of enzymes and proteins. Anal Bioanal Chem. 2012;402:299-314 pubmed publisher
    ..5 or greater. ..
  4. He W, Lu Y, Qi J, Chen L, Hu F, Wu W. Nanoemulsion-templated shell-crosslinked nanocapsules as drug delivery systems. Int J Pharm. 2013;445:69-78 pubmed publisher
    ..Furthermore, the presence of surface food proteins introduces carboxyl and amine moieties, which enables the nanocapsules to anchor ligands, suggesting its potential application in targeting drug delivery, bioimaging and therapeutics. ..
  5. He W, Lu Y, Qi J, Chen L, Hu F, Wu W. Food proteins as novel nanosuspension stabilizers for poorly water-soluble drugs. Int J Pharm. 2013;441:269-78 pubmed publisher
    ..It is concluded that the three denatured proteins perform as efficient stabilizers for indomethacin nanosuspensions. ..
  6. Cam A, de Mejia E. RGD-peptide lunasin inhibits Akt-mediated NF-?B activation in human macrophages through interaction with the ?V?3 integrin. Mol Nutr Food Res. 2012;56:1569-81 pubmed publisher
    ..Lunasin inhibited ?V?3 integrin-mediated proinflammatory markers and downregulated Akt-mediated NF-?B pathways through interaction with ?V?3 integrin. ..
  7. Dia V, de Mejia E. Differential gene expression of RAW 264.7 macrophages in response to the RGD peptide lunasin with and without lipopolysaccharide stimulation. Peptides. 2011;32:1979-88 pubmed publisher
    ..These findings support the potential chemopreventive and chemotherapeutic use of lunasin against cancer. ..
  8. Dia V, Gonzalez de Mejia E. Lunasin potentiates the effect of oxaliplatin preventing outgrowth of colon cancer metastasis, binds to ?5?1 integrin and suppresses FAK/ERK/NF-?B signaling. Cancer Lett. 2011;313:167-80 pubmed publisher
    ..Lunasin inhibited metastasis of human colon cancer cells by direct binding with ?5?1 integrin suppressing FAK/ERK/NF-?B signaling, and potentiated the effect of oxaliplatin in preventing the outgrowth of metastasis. ..
  9. Toden S, Bird A, Topping D, Conlon M. Differential effects of dietary whey, casein and soya on colonic DNA damage and large bowel SCFA in rats fed diets low and high in resistant starch. Br J Nutr. 2007;97:535-43 pubmed
    ..The data show also that these changes were reversed by RS. ..

More Information


  1. Zhang G, Chen M, Li L, Xu Z, Chen X, Guo J, et al. Overexpression of the soybean GmERF3 gene, an AP2/ERF type transcription factor for increased tolerances to salt, drought, and diseases in transgenic tobacco. J Exp Bot. 2009;60:3781-96 pubmed publisher
    ..The overall results suggested that GmERF3 as an AP2/ERF transcription factor may play dual roles in response to biotic and abiotic stresses in plants. ..
  2. Veldhorst M, Nieuwenhuizen A, Hochstenbach Waelen A, van Vught A, Westerterp K, Engelen M, et al. Dose-dependent satiating effect of whey relative to casein or soy. Physiol Behav. 2009;96:675-82 pubmed
    ..The results suggest that a difference in appetite ratings between types of protein appears when certain amino acids are above and below particular threshold values. ..
  3. Kim M, Kim J, Nam S, Ryu S, Kong G. Dietary intake of soy protein and tofu in association with breast cancer risk based on a case-control study. Nutr Cancer. 2008;60:568-76 pubmed publisher
    ..01). We concluded that increased regular soy food intake at a level equivalent to traditional Korean consumption levels may be associated with a reduced risk of breast cancer, and this effect is more pronounced in premenopausal women. ..
  4. Chen L, Remondetto G, Rouabhia M, Subirade M. Kinetics of the breakdown of cross-linked soy protein films for drug delivery. Biomaterials. 2008;29:3750-6 pubmed publisher
    ..SPI film networks displayed excellent compound binding capacity, especially for hydrophobic molecules, and hence potential for use in controlled release systems based on matrix erosion. ..
  5. Sun P, Li D, Li Z, Dong B, Wang F. Effects of glycinin on IgE-mediated increase of mast cell numbers and histamine release in the small intestine. J Nutr Biochem. 2008;19:627-33 pubmed publisher
    ..The severity of the hypersensitive reactions depends on the dose of glycinin. Higher dose may cause more severe anaphylactic symptoms. ..
  6. Torre Villalvazo I, Tovar A, Ramos Barragán V, Cerbón Cervantes M, Torres N. Soy protein ameliorates metabolic abnormalities in liver and adipose tissue of rats fed a high fat diet. J Nutr. 2008;138:462-8 pubmed
    ..These results suggest that the type of protein consumed and the presence of fat in the diet modulate lipid metabolism in adipose tissue and liver. ..
  7. Simmen F, Mercado C, Zavacki A, Huang S, Greenway A, Kang P, et al. Soy protein diet alters expression of hepatic genes regulating fatty acid and thyroid hormone metabolism in the male rat. J Nutr Biochem. 2010;21:1106-13 pubmed publisher
    ..Identification of the regulation, by genistein and soy protein, of iodothyronine deiodinase synthesis has potential applications for treatment and prevention of fatty liver disease and obesity. ..
  8. Hernández Ledesma B, Hsieh C, de Lumen B. Antioxidant and anti-inflammatory properties of cancer preventive peptide lunasin in RAW 264.7 macrophages. Biochem Biophys Res Commun. 2009;390:803-8 pubmed publisher
    ..On the basis of these potent antioxidant and anti-inflammatory properties, we propose lunasin not only as a cancer preventive and therapeutic agent but also as an agent against other inflammatory-related disorders. ..
  9. Gardner C, Messina M, Kiazand A, Morris J, Franke A. Effect of two types of soy milk and dairy milk on plasma lipids in hypercholesterolemic adults: a randomized trial. J Am Coll Nutr. 2007;26:669-77 pubmed
    ..The effect did not differ by type of soy milk and neither soy milk significantly affected other lipid variables, insulin or glucose. ..
  10. Wang W, Dia V, Vasconez M, de Mejia E, Nelson R. Analysis of soybean protein-derived peptides and the effect of cultivar, environmental conditions, and processing on lunasin concentration in soybean and soy products. J AOAC Int. 2008;91:936-46 pubmed
    ..In addition, lunasin concentration in soybean depends mainly on cultivar and to some extent on environmental factors, particularly temperature. Lunasin concentration in soy products was also affected by processing conditions. ..
  11. Tamaru S, Kurayama T, Sakono M, Fukuda N, Nakamori T, Furuta H, et al. Effects of dietary soybean peptides on hepatic production of ketone bodies and secretion of triglyceride by perfused rat liver. Biosci Biotechnol Biochem. 2007;71:2451-7 pubmed
    ..There is a possibility that soybean peptides modulate triglyceride metabolism by changes in the hepatic contribution. ..
  12. Hernández Ledesma B, Hsieh C, de Lumen B. Lunasin, a novel seed peptide for cancer prevention. Peptides. 2009;30:426-30 pubmed publisher
    ..The purpose of this article is to review the discovery of this seed peptide and the most recent evidence on its possible benefits as an anticancer agent. ..
  13. Azadbakht L, Esmaillzadeh A. Soy-protein consumption and kidney-related biomarkers among type 2 diabetics: a crossover, randomized clinical trial. J Ren Nutr. 2009;19:479-86 pubmed publisher
    ..Soy-protein consumption reduces proteinuria in type 2 diabetes with nephropathy. ..
  14. Dia V, Mejia E. Lunasin promotes apoptosis in human colon cancer cells by mitochondrial pathway activation and induction of nuclear clusterin expression. Cancer Lett. 2010;295:44-53 pubmed publisher
    ..In conclusion, lunasin stimulated apoptosis in HT-29 cells by activating apoptotic mitochondrial pathways and inducing expression of the pro-apoptotic nuclear clusterin. ..
  15. Hsieh C, Hernández Ledesma B, de Lumen B. Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact. 2010;186:127-34 pubmed publisher
    ..Therefore, our results suggest that a combination of these two compounds is a promising strategy to prevent/treat breast cancer. ..
  16. Anderson J. Beneficial effects of soy protein consumption for renal function. Asia Pac J Clin Nutr. 2008;17 Suppl 1:324-8 pubmed
    ..Further studies are required to discern the specific benefits of soy protein and its components on renal function in diabetic subjects. ..
  17. Consonni A, Lovati M, Manzoni C, Pizzagalli A, Morazzoni P, Duranti M. Cloning, yeast expression, purification and biological activity of a truncated form of the soybean 7S globulin alpha' subunit involved in Hep G2 cell cholesterol homeostasis. J Nutr Biochem. 2010;21:887-91 pubmed publisher
    ..These findings open new prospects in the studies aimed at identifying soybean regulatory (poly)peptide(s) and the mechanism involved in this biological response, as a gateway to their utilization for the management of human health. ..
  18. Hsieh C, Hernández Ledesma B, Jeong H, Park J, de Lumen B. Complementary roles in cancer prevention: protease inhibitor makes the cancer preventive peptide lunasin bioavailable. PLoS ONE. 2010;5:e8890 pubmed publisher
    ..We conclude that lunasin is actually the bioactive cancer preventive agent in BBIC, and BBI simply protects lunasin from digestion when soybean and other seed foods are eaten by humans. ..
  19. Han P, Ma X, Yin J. The effects of lipoic acid on soybean beta-conglycinin-induced anaphylactic reactions in a rat model. Arch Anim Nutr. 2010;64:254-64 pubmed publisher
    ..Taken together, our results suggest that a low dose of lipoic acid could potentially be used as an immunomodulator to attenuate soybean beta-conglycinin induced allergies. ..
  20. Singhal R, Shankar K, Badger T, Ronis M. Hepatic gene expression following consumption of soy protein isolate in female Sprague-Dawley rats differs from that produced by 17{beta}-estradiol treatment. J Endocrinol. 2009;202:141-52 pubmed publisher
    ..The different hepatic gene signatures produced by SPI feeding compared with E(2) and the lack of increase in uterine wet weight in rats fed with SPI suggest that SPI is not estrogenic in these tissues. ..
  21. Su Y, Shankar K, Simmen R. Early soy exposure via maternal diet regulates rat mammary epithelial differentiation by paracrine signaling from stromal adipocytes. J Nutr. 2009;139:945-51 pubmed publisher
  22. Hernández Ledesma B, Hsieh C, de Lumen B. Relationship between lunasin's sequence and its inhibitory activity of histones H3 and H4 acetylation. Mol Nutr Food Res. 2011;55:989-98 pubmed publisher
    ..Results from this study demonstrates lunasin's role as modulator of histone acetylation and protein expression that might contribute on its chemopreventive properties against breast cancer. ..
  23. Veldhorst M, Nieuwenhuizen A, Hochstenbach Waelen A, Westerterp K, Engelen M, Brummer R, et al. Effects of high and normal soyprotein breakfasts on satiety and subsequent energy intake, including amino acid and 'satiety' hormone responses. Eur J Nutr. 2009;48:92-100 pubmed publisher
    ..001). There was no difference in EI (25 En%: 3,212 +/- 280 kJ vs. 10 En%: 3,098 +/- 286 kJ, ns). A high soyprotein breakfast is more satiating than a normal soyprotein breakfast related to elevated taurine and insulin concentrations. ..
  24. Komatsu S, Ahsan N. Soybean proteomics and its application to functional analysis. J Proteomics. 2009;72:325-36 pubmed publisher
    ..In this review, we discuss the strengths and weaknesses of proteomics technologies in soybean biology and we examine the limitations of current techniques. ..
  25. Xiao R, Su Y, Simmen R, Simmen F. Dietary soy protein inhibits DNA damage and cell survival of colon epithelial cells through attenuated expression of fatty acid synthase. Am J Physiol Gastrointest Liver Physiol. 2008;294:G868-76 pubmed publisher
  26. Bhatia J, Greer F. Use of soy protein-based formulas in infant feeding. Pediatrics. 2008;121:1062-8 pubmed publisher
    ..This report reviews the limited indications and contraindications of soy formulas. It will also review the potential harmful effects of soy protein-based formulas and the phytoestrogens contained in these formulas. ..
  27. Jeong H, Jeong J, Kim D, Park J, Lee J, Kweon D, et al. The cancer preventive peptide lunasin from wheat inhibits core histone acetylation. Cancer Lett. 2007;255:42-8 pubmed
    ..The amounts of lunasin in the developing seeds and in the rat liver correlated extremely well with the extent of inhibition of core histone acetylation. ..
  28. Natarajan S. Natural variability in abundance of prevalent soybean proteins. Regul Toxicol Pharmacol. 2010;58:S26-9 pubmed publisher
    ..This information is useful for scientists and regulatory agencies to determine whether the unintended expression of proteins found in transgenic soybean is within the range of natural variation. ..
  29. Vupadhyayula P, Gallagher J, Templin T, Logsdon S, Smith L. Effects of soy protein isolate on bone mineral density and physical performance indices in postmenopausal women--a 2-year randomized, double-blind, placebo-controlled trial. Menopause. 2009;16:320-8 pubmed publisher
    ..Physical performance measurements decreased in all the groups. : Twenty-five grams of soy protein with 90 mg of isoflavones has no added benefit in preventing bone loss or improving physical performance. ..
  30. Wagner J, Zhang L, Shadoan M, Kavanagh K, Chen H, Tresnasari K, et al. Effects of soy protein and isoflavones on insulin resistance and adiponectin in male monkeys. Metabolism. 2008;57:S24-31 pubmed publisher
    ..Further studies are needed to determine the mechanisms involved in these effects of a high-soy isoflavone diet and to optimize dietary isoflavone content for maximal health benefits in male subjects. ..
  31. Brandão A, Barbosa H, Arruda M. Image analysis of two-dimensional gel electrophoresis for comparative proteomics of transgenic and non-transgenic soybean seeds. J Proteomics. 2010;73:1433-40 pubmed publisher
    ..From this, 10 proteins displayed significant differences in expression, and eight of them were characterized and identified by mass spectrometry. ..
  32. Cunha N, Murad A, Cipriano T, Araujo A, Aragão F, Leite A, et al. Expression of functional recombinant human growth hormone in transgenic soybean seeds. Transgenic Res. 2011;20:811-26 pubmed publisher
    ..These results demonstrate that the utilisation of tissue-specific regulatory sequences is an attractive and viable option for achieving high-yield production of recombinant proteins in stable transgenic soybean seeds. ..
  33. Adams M, Anthony M, Chen H, Clarkson T. Replacement of dietary soy protein isolate with concentrates of soy 7S or 11S globulin has minimal or no effects on plasma lipoprotein profiles and biomarkers of coronary risk in monkeys. Atherosclerosis. 2008;196:76-80 pubmed
    ..Replacement of dietary soy protein isolate with concentrated 7S or 11S does not result in improvement of plasma lipoprotein profiles or cardiovascular biomarkers in monkeys. ..
  34. Velasquez M, Bhathena S. Role of dietary soy protein in obesity. Int J Med Sci. 2007;4:72-82 pubmed
    ..In addition, the potential of soy protein in causing food allergy in humans is briefly discussed. ..
  35. Wei W, Huang J, Hao Y, Zou H, Wang H, Zhao J, et al. Soybean GmPHD-type transcription regulators improve stress tolerance in transgenic Arabidopsis plants. PLoS ONE. 2009;4:e7209 pubmed publisher
    ..This tolerance was likely achieved by diminishing the oxidative stress through regulation of downstream genes. These results provide important clues for soybean stress tolerance through manipulation of PHD-type transcription regulator. ..
  36. Taku K, Umegaki K, Sato Y, Taki Y, Endoh K, Watanabe S. Soy isoflavones lower serum total and LDL cholesterol in humans: a meta-analysis of 11 randomized controlled trials. Am J Clin Nutr. 2007;85:1148-56 pubmed
    ..Soy protein that contained enriched or depleted isoflavones also significantly improved lipid profiles. Reductions in LDL cholesterol were larger in hypercholesterolemic than in normocholesterolemic subjects. ..
  37. de Mejia E, Dia V. Lunasin and lunasin-like peptides inhibit inflammation through suppression of NF-kappaB pathway in the macrophage. Peptides. 2009;30:2388-98 pubmed publisher
    ..In conclusion, lunasin and lunasin-like peptides purified from defatted soybean flour inhibited inflammation in LPS-induced RAW 264.7 macrophage by suppressing NF-kappaB pathway. ..
  38. Xiao R, Hennings L, Badger T, Simmen F. Fetal programming of colon cancer in adult rats: correlations with altered neonatal growth trajectory, circulating IGF-I and IGF binding proteins, and testosterone. J Endocrinol. 2007;195:79-87 pubmed
    ..Results indicate an effect of dietary protein type during pregnancy on colon tumor multiplicity and colon tissue gene expression, and serum IGF-I and testosterone in progeny rats as later adults. ..
  39. Castro Rubio F, Marina M, García M. Perfusion reversed-phase high-performance liquid chromatography/mass spectrometry analysis of intact soybean proteins for the characterization of soybean cultivars. J Chromatogr A. 2007;1170:34-43 pubmed
    ..ESI-MS) was employed for the characterization of soybean cultivars through the analysis of intact soybean proteins. The similarities and differences between yellow soybeans (the most usual soybeans) and other beans with ..
  40. Gonzalez D, Vodkin L. Specific elements of the glyoxylate pathway play a significant role in the functional transition of the soybean cotyledon during seedling development. BMC Genomics. 2007;8:468 pubmed
  41. Fan J, Zhang Y, Chang X, Saito M, Li Z. Changes in the radical scavenging activity of bacterial-type douchi, a traditional fermented soybean product, during the primary fermentation process. Biosci Biotechnol Biochem. 2009;73:2749-53 pubmed
    ..These results suggest that soybean peptides rather than isoflavones result in variations in antioxidant activity in bacterial-type douchi. ..
  42. He W, Tan Y, Tian Z, Chen L, Hu F, Wu W. Food protein-stabilized nanoemulsions as potential delivery systems for poorly water-soluble drugs: preparation, in vitro characterization, and pharmacokinetics in rats. Int J Nanomedicine. 2011;6:521-33 pubmed publisher
    ..It is concluded that an oil/water nanoemulsion system with good biocompatibility can be prepared by using food proteins as emulsifiers, allowing better and more rapid absorption of lipophilic drugs. ..
  43. Dia V, Gonzalez de Mejia E. Lunasin induces apoptosis and modifies the expression of genes associated with extracellular matrix and cell adhesion in human metastatic colon cancer cells. Mol Nutr Food Res. 2011;55:623-34 pubmed publisher
    ..01-, 6.53-, 7.71-, 8.19- and 10.10-fold, respectively, while upregulating COL12A1 by 11.61-fold. Lunasin can be used in cases where resistance to chemotherapy developed. ..
  44. Kenny A, Mangano K, Abourizk R, Bruno R, Anamani D, Kleppinger A, et al. Soy proteins and isoflavones affect bone mineral density in older women: a randomized controlled trial. Am J Clin Nutr. 2009;90:234-42 pubmed publisher
    ..The negative correlation between dietary protein and bone turnover suggests that increasing protein intakes may suppress skeletal turnover. This trial was registered at as NCT00668447. ..
  45. Imani H, Tabibi H, Atabak S, Rahmani L, Ahmadinejad M, Hedayati M. Effects of soy consumption on oxidative stress, blood homocysteine, coagulation factors, and phosphorus in peritoneal dialysis patients. J Ren Nutr. 2009;19:389-95 pubmed publisher
    ..Soy consumption reduces plasma coagulation factor IX activity, which is a risk factor for thrombosis in peritoneal dialysis patients. ..
  46. Chen J, Lazarenko O, Blackburn M, Badeaux J, Badger T, Ronis M. Infant formula promotes bone growth in neonatal piglets by enhancing osteoblastogenesis through bone morphogenic protein signaling. J Nutr. 2009;139:1839-47 pubmed publisher
    ..SF piglets had the highest bone volume over tissue volume. This suggests that SF-fed piglets may have the best quality bone. The anabolic effects of SF on bone appear to be mediated through enhanced BMP signaling. ..
  47. Dia V, Torres S, de Lumen B, Erdman J, de Mejia E. Presence of lunasin in plasma of men after soy protein consumption. J Agric Food Chem. 2009;57:1260-6 pubmed publisher
    ..No peptides from lunasin were present in plasma samples without soy intake. The results of this study suggest that lunasin is bioavailable in humans, an important requirement for its anticancer potential. ..
  48. Mochizuki Y, Maebuchi M, Kohno M, Hirotsuka M, Wadahama H, Moriyama T, et al. Changes in lipid metabolism by soy beta-conglycinin-derived peptides in HepG2 cells. J Agric Food Chem. 2009;57:1473-80 pubmed publisher
    ..From these results, it may be concluded that the peptides derived from 7S altered the lipid metabolism to decrease secretion of apolipoprotein B-100-containing lipoprotein from HepG2 cells. ..
  49. Sirtori C, Galli C, Anderson J, Arnoldi A. Nutritional and nutraceutical approaches to dyslipidemia and atherosclerosis prevention: Focus on dietary proteins. Atherosclerosis. 2009;203:8-17 pubmed publisher
    ..Active peptides have been identified for the latter indication, whereas works is in progress in attempting to identify specific cholesterol lowering peptides. ..
  50. Jaceldo Siegl K, Fraser G, Chan J, Franke A, Sabate J. Validation of soy protein estimates from a food-frequency questionnaire with repeated 24-h recalls and isoflavonoid excretion in overnight urine in a Western population with a wide range of soy intakes. Am J Clin Nutr. 2008;87:1422-7 pubmed
    ..The Adventist Health Study-2 FFQ is a valid instrument for assessing soy protein in a population with a wide range of soy intakes. ..
  51. Chen F, Hao Y, Piao X, Ma X, Wu G, Qiao S, et al. Soybean-derived beta-conglycinin affects proteome expression in pig intestinal cells in vivo and in vitro. J Anim Sci. 2011;89:743-53 pubmed publisher
    ..Collectively, these novel results indicate that ?-conglycinin directly induces intestinal damage by depressing intestinal-cell growth, damaging the cytoskeleton, and causing apoptosis in the piglet intestine. ..
  52. Park J, Jeong H, Lumen B. In vitro digestibility of the cancer-preventive soy peptides lunasin and BBI. J Agric Food Chem. 2007;55:10703-6 pubmed
    ..The role of other soy protease inhibitors such as Kunitz Trypsin Inhibitor (KTI) cannot be excluded from these experiments. ..
  53. Gilchrist J, Moore M, Andres A, Estroff J, Badger T. Ultrasonographic patterns of reproductive organs in infants fed soy formula: comparisons to infants fed breast milk and milk formula. J Pediatr. 2010;156:215-20 pubmed publisher
    ..To determine if differences exist in hormone-sensitive organ size between infants who were fed soy formula (SF), milk formula (MF), or breast milk (BF)...