trichomonas vaginalis

Summary

Summary: A species of TRICHOMONAS that produces a refractory vaginal discharge in females, as well as bladder and urethral infections in males.

Top Publications

  1. Nye M, Schwebke J, Body B. Comparison of APTIMA Trichomonas vaginalis transcription-mediated amplification to wet mount microscopy, culture, and polymerase chain reaction for diagnosis of trichomoniasis in men and women. Am J Obstet Gynecol. 2009;200:188.e1-7 pubmed publisher
    We evaluated the performance characteristics of APTIMA Trichomonas vaginalis (ATV) transcription-mediated amplification (TMA) for diagnosis of T vaginalis (TV) infection from female vaginal swab, endocervical swab, and urine specimens ..
  2. Yuan Y, Xue C. [Influence of iron ion on the growth of Trichomonas vaginalis in vitro]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2010;28:273-6 pubmed
    To study the influence of iron ion on the growth of Trichomonas vaginalis in vitro. Quantitative pure incubation of T...
  3. Al Saeed W. Detection of Trichomonas vaginalis by different methods in women from Dohok province, Iraq. East Mediterr Health J. 2011;17:706-9 pubmed
    ..The rate varied significantly by age and was highest in young women aged 20-25 years (7.6%) and lowest in the age group 36-40 years (2.2%). The highest rate of infection with T vaginalis was detected by Diamond modified culture. ..
  4. Gaydos C, Barnes M, Quinn N, Jett Goheen M, Hsieh Y. Trichomonas vaginalis infection in men who submit self-collected penile swabs after internet recruitment. Sex Transm Infect. 2013;89:504-8 pubmed publisher
    ..Submission of self-collected penile samples collected at home could remove barriers that men face in getting tested for sexually transmitted infections (STIs)...
  5. Kusdian G, Woehle C, Martin W, Gould S. The actin-based machinery of Trichomonas vaginalis mediates flagellate-amoeboid transition and migration across host tissue. Cell Microbiol. 2013;15:1707-21 pubmed publisher
    b>Trichomonas vaginalis is the most widespread non-viral pathogen of the human urogenital tract, infecting ??3% of the world's population annually...
  6. Fichorova R, Buck O, Yamamoto H, Fashemi T, Dawood H, Fashemi B, et al. The villain team-up or how Trichomonas vaginalis and bacterial vaginosis alter innate immunity in concert. Sex Transm Infect. 2013;89:460-6 pubmed publisher
    ..Colonised epithelia were infected with Trichomonas vaginalis (TV) or exposed to purified TV virulence factors (membrane lipophosphoglycan (LPG), its ceramide-..
  7. Lama A, Kucknoor A, Mundodi V, Alderete J. Glyceraldehyde-3-phosphate dehydrogenase is a surface-associated, fibronectin-binding protein of Trichomonas vaginalis. Infect Immun. 2009;77:2703-11 pubmed publisher
    b>Trichomonas vaginalis colonizes the urogenital tract of humans and causes trichomonosis, the most prevalent nonviral sexually transmitted disease. We have shown an association of T...
  8. Westrop G, Georg I, Coombs G. The mercaptopyruvate sulfurtransferase of Trichomonas vaginalis links cysteine catabolism to the production of thioredoxin persulfide. J Biol Chem. 2009;284:33485-94 pubmed publisher
    b>Trichomonas vaginalis is a protozoan parasite of humans that is able to synthesize cysteine de novo using cysteine synthase but does not produce glutathione...
  9. Depuydt C, Leuridan E, Van Damme P, Bogers J, Vereecken A, Donders G. Epidemiology of Trichomonas vaginalis and human papillomavirus infection detected by real-time PCR in flanders. Gynecol Obstet Invest. 2010;70:273-80 pubmed publisher
    The goal of this cross-sectional laboratory-based study is to investigate the association between Trichomonas vaginalis (TV) and human papillomavirus (HPV) infections in cervical samples in Flanders...

More Information

Publications127 found, 100 shown here

  1. Goodman R, Freret T, Kula T, Geller A, Talkington M, Tang Fernandez V, et al. Clinical isolates of Trichomonas vaginalis concurrently infected by strains of up to four Trichomonasvirus species (Family Totiviridae). J Virol. 2011;85:4258-70 pubmed publisher
    b>Trichomonas vaginalis, which causes the most common nonviral sexually transmitted disease worldwide, is itself commonly infected by nonsegmented double-stranded RNA (dsRNA) viruses from the genus Trichomonasvirus, family Totiviridae...
  2. KAY C, Woodward K, Lawler K, Self T, Dyall S, Kerr I. The ATP-binding cassette proteins of the deep-branching protozoan parasite Trichomonas vaginalis. PLoS Negl Trop Dis. 2012;6:e1693 pubmed publisher
    ..To date, there has been no attempt to investigate this class of proteins in the infectious parasite Trichomonas vaginalis. We have utilized a combination of bioinformatics, gene sequence analysis, gene expression and confocal ..
  3. Henning T, Fakile Y, Phillips C, Sweeney E, Mitchell J, Patton D, et al. Development of a pigtail macaque model of sexually transmitted infection/HIV coinfection using Chlamydia trachomatis, Trichomonas vaginalis, and SHIV(SF162P3). J Med Primatol. 2011;40:214-23 pubmed publisher
    ..and HIV infection, we evaluated the capacity of the pigtail macaque model to sustain triple infection with Trichomonas vaginalis, Chlamydia trachomatis, and SHIV(SF162P3)...
  4. Gould S, Woehle C, Kusdian G, Landan G, Tachezy J, Zimorski V, et al. Deep sequencing of Trichomonas vaginalis during the early infection of vaginal epithelial cells and amoeboid transition. Int J Parasitol. 2013;43:707-19 pubmed publisher
    The human pathogen Trichomonas vaginalis has the largest protozoan genome known, potentially encoding approximately 60,000 proteins...
  5. Muñoz C, Perez M, Orrego P, Osorio L, Gutiérrez B, Sagua H, et al. A protein phosphatase 1 gamma (PP1?) of the human protozoan parasite Trichomonas vaginalis is involved in proliferation and cell attachment to the host cell. Int J Parasitol. 2012;42:715-27 pubmed publisher
    In this work, evidence for a critical role of Trichomonas vaginalis protein phosphatase 1 gamma (TvPP1?) in proliferation and attachment of the parasite to the mammalian cell is provided. Firstly, proliferation and attachment of T...
  6. de Miguel N, Riestra A, Johnson P. Reversible association of tetraspanin with Trichomonas vaginalis flagella upon adherence to host cells. Cell Microbiol. 2012;14:1797-807 pubmed publisher
    The parasite Trichomonas vaginalis is the causative agent of trichomoniasis, a prevalent sexually transmitted infection. Here, we report the cellular analyses of T.?vaginalis tetraspanin 6 (TvTSP6)...
  7. Horvathova L, Safarikova L, Basler M, Hrdy I, Campo N, Shin J, et al. Transcriptomic identification of iron-regulated and iron-independent gene copies within the heavily duplicated Trichomonas vaginalis genome. Genome Biol Evol. 2012;4:1017-29 pubmed publisher
    ..evolutionary mechanism and no eukaryote has more duplicated gene families than the parasitic protist Trichomonas vaginalis. Iron is an essential nutrient for Trichomonas and plays a pivotal role in the establishment of infection, ..
  8. Goodhew E, Secor W. Drug library screening against metronidazole-sensitive and metronidazole-resistant Trichomonas vaginalis isolates. Sex Transm Infect. 2013;89:479-84 pubmed publisher
    ..most patients with trichomoniasis but not for individuals who are infected with very resistant strains of Trichomonas vaginalis or persons with hypersensitivity to the 5-nitroimidazole drugs...
  9. Sithiprom S, Petmitr S, Chavalitshewinkoon Petmitr P. Partial purification and characterization of Trichomonas vaginalis DNA topoisomerase II. Southeast Asian J Trop Med Public Health. 2009;40:877-85 pubmed
    ..Drug resistance to Trichomonas vaginalis, a common sexually transmitted protozoan parasite, is increasing worldwide, and DNA topoisomerase II may ..
  10. Im S, Ahn M, Han I, Song H, Kim Y, Kim H, et al. Histamine and TNF-alpha release by rat peritoneal mast cells stimulated with Trichomonas vaginalis. Parasite. 2011;18:49-55 pubmed
    ..vaginalis, and the mast cells activated with T. vaginalis showed an increased release of histamine and TNF-alpha. Therefore, mast cells may be involved in the inflammatory response caused by T. vaginalis...
  11. Muzny C, Barnes A, Mena L. Symptomatic Trichomonas vaginalis infection in the setting of severe nitroimidazole allergy: successful treatment with boric acid. Sex Health. 2012;9:389-91 pubmed publisher
    This report describes a patient with symptomatic Trichomonas vaginalis infection who was unable to tolerate nitroimidazole drugs because of severe hypersensitivity, for which desensitisation was not possible...
  12. Storti Filho A, Souza P, Chassot F, Pereira M, Souza R, Mello I, et al. Association of public versus private health care utilization and prevalence of Trichomonas vaginalis in Maringá, Paraná, Brazil. Arch Gynecol Obstet. 2009;280:593-7 pubmed publisher
    To determine the association of public versus private health care utilization and prevalence of Trichomonas vaginalis in Maringá, Paraná, Brazil...
  13. Thurman A, Doncel G. Innate immunity and inflammatory response to Trichomonas vaginalis and bacterial vaginosis: relationship to HIV acquisition. Am J Reprod Immunol. 2011;65:89-98 pubmed publisher
    ..often asymptomatic lower genital tract infections, including bacterial vaginosis (BV) and trichomoniasis (Trichomonas vaginalis- TV), increase a woman's susceptibility to HIV-1 genital infection, given an exposure...
  14. Lustig G, Ryan C, Secor W, Johnson P. Trichomonas vaginalis contact-dependent cytolysis of epithelial cells. Infect Immun. 2013;81:1411-9 pubmed publisher
    b>Trichomonas vaginalis is an extracellular protozoan parasite that binds to the epithelium of the human urogenital tract during infection. In this study, we examined the propensities of 26 T...
  15. Bosserman E, Helms D, Mosure D, Secor W, Workowski K. Utility of antimicrobial susceptibility testing in Trichomonas vaginalis-infected women with clinical treatment failure. Sex Transm Dis. 2011;38:983-7 pubmed publisher
    ..resistance is one of the causes of treatment failure in women after standard nitroimidazole therapy for Trichomonas vaginalis infections...
  16. Schneider R, Brown M, Shiflett A, Dyall S, Hayes R, Xie Y, et al. The Trichomonas vaginalis hydrogenosome proteome is highly reduced relative to mitochondria, yet complex compared with mitosomes. Int J Parasitol. 2011;41:1421-34 pubmed publisher
    The human pathogen Trichomonas vaginalis lacks conventional mitochondria and instead contains divergent mitochondrial-related organelles. These double-membrane bound organelles, called hydrogenosomes, produce molecular hydrogen...
  17. Peterman T, Tian L, Metcalf C, Malotte C, Paul S, Douglas J. Persistent, undetected Trichomonas vaginalis infections?. Clin Infect Dis. 2009;48:259-60 pubmed publisher
  18. Rocha T, de Brum Vieira P, Gnoatto S, Tasca T, Gosmann G. Anti-Trichomonas vaginalis activity of saponins from Quillaja, Passiflora, and Ilex species. Parasitol Res. 2012;110:2551-6 pubmed publisher
    b>Trichomonas vaginalis is a flagellated protozoan that causes trichomonosis, the most prevalent non-viral STD worldwide...
  19. Campbell L, Woods V, Lloyd T, Elsayed S, Church D. Evaluation of the OSOM Trichomonas rapid test versus wet preparation examination for detection of Trichomonas vaginalis vaginitis in specimens from women with a low prevalence of infection. J Clin Microbiol. 2008;46:3467-9 pubmed publisher
    ..rapid test (OSOM Trich) was compared to the wet preparation examination (WP) for the detection of Trichomonas vaginalis vaginitis in women with a low prevalence of infection. A total of 19/1,009 (2%) women had T...
  20. Sutcliffe S, Alderete J, Till C, Goodman P, Hsing A, Zenilman J, et al. Trichomonosis and subsequent risk of prostate cancer in the Prostate Cancer Prevention Trial. Int J Cancer. 2009;124:2082-7 pubmed publisher
    ..association between a history of trichomonosis, a sexually transmitted infection caused by the protozoan, Trichomonas vaginalis, and prostate cancer risk in the Health Professionals Follow-up Study...
  21. Figueroa Angulo E, Estrella Hernández P, Salgado Lugo H, Ochoa Leyva A, Gomez Puyou A, Campos S, et al. Cellular and biochemical characterization of two closely related triosephosphate isomerases from Trichomonas vaginalis. Parasitology. 2012;139:1729-38 pubmed publisher
    ..Here we report that Trichomonas vaginalis contains 2 fully functional tpi genes...
  22. Shafir S, Sorvillo F, Smith L. Current issues and considerations regarding trichomoniasis and human immunodeficiency virus in African-Americans. Clin Microbiol Rev. 2009;22:37-45, Table of Contents pubmed publisher
    b>Trichomonas vaginalis has long been recognized as one of the most prevalent sexually transmitted infections...
  23. Chapin K, Andrea S. APTIMA® Trichomonas vaginalis, a transcription-mediated amplification assay for detection of Trichomonas vaginalis in urogenital specimens. Expert Rev Mol Diagn. 2011;11:679-88 pubmed publisher
    The APTIMA(®) Trichomonas vaginalis (APTIMA TV; Gen-Probe Inc.) assay is the only amplification-based assay for T. vaginalis (TV) currently cleared by the US FDA. The assay was cleared in April 2011...
  24. Lewis D, Marsh K, Radebe F, Maseko V, Hughes G. Trends and associations of Trichomonas vaginalis infection in men and women with genital discharge syndromes in Johannesburg, South Africa. Sex Transm Infect. 2013;89:523-7 pubmed publisher
    To better understand the epidemiology of Trichomonas vaginalis infection, we investigated the association between T vaginalis and demographic, clinical, microbiological and behavioural characteristics of patients presenting with genital ..
  25. Hobbs M, Sena A. Modern diagnosis of Trichomonas vaginalis infection. Sex Transm Infect. 2013;89:434-8 pubmed publisher
    Recent advances in tests for the sexually transmitted protozoan parasite Trichomonas vaginalis have increased opportunities for diagnosis and treatment of this important sexually transmitted infection...
  26. Pattullo L, Griffeth S, Ding L, Mortensen J, Reed J, Kahn J, et al. Stepwise diagnosis of Trichomonas vaginalis infection in adolescent women. J Clin Microbiol. 2009;47:59-63 pubmed publisher
    ..effects of clinical factors and of the type and timing of a secondary test in improving the sensitivity of Trichomonas vaginalis detection in young women over that of a wet mount alone...
  27. Smid O, Matusková A, Harris S, Kucera T, Novotny M, Horvathova L, et al. Reductive evolution of the mitochondrial processing peptidases of the unicellular parasites trichomonas vaginalis and giardia intestinalis. PLoS Pathog. 2008;4:e1000243 pubmed publisher
    ..highly reduced versions of mitochondria, the mitosomes of Giardia intestinalis and the hydrogenosomes of Trichomonas vaginalis. Our biochemical characterization of recombinant proteins showed that, contrary to a recent report, the ..
  28. De Jesus J, Cuervo P, Britto C, Saboia Vahia L, Costa e Silva Filho F, Borges Veloso A, et al. Cysteine peptidase expression in Trichomonas vaginalis isolates displaying high- and low-virulence phenotypes. J Proteome Res. 2009;8:1555-64 pubmed publisher
    In the present study, we identified and characterized the cysteine peptidase (CP) profiles of Trichomonas vaginalis isolates exhibiting high- and low-virulence phenotypes using a combination of two-dimensional SDS-PAGE (2DE), tandem mass ..
  29. Giordani R, Vieira P, Weizenmann M, Rosemberg D, Souza A, Bonorino C, et al. Candimine-induced cell death of the amitochondriate parasite Trichomonas vaginalis. J Nat Prod. 2010;73:2019-23 pubmed publisher
    ..from the bulbs of Hippeastrum morelianum, was found to be cytotoxic for the amitochondriate parasite Trichomonas vaginalis. Candimine (1) induced cell death with an unprecedented group of effects that failed to fulfill the ..
  30. Carvajal Gamez B, Arroyo R, Camacho Nuez M, Lira R, Martínez Benitez M, Alvarez Sánchez M. Putrescine is required for the expression of eif-5a in Trichomonas vaginalis. Mol Biochem Parasitol. 2011;180:8-16 pubmed publisher
    Recently, we found that Trichomonas vaginalis contains a eukaryotic translation initiation factor 5A (TveIF-5A) with unknown function in this parasite...
  31. Zub cov Z, Hostomsk J, Tachezy J. Histone H3 Variants in Trichomonas vaginalis. Eukaryot Cell. 2012;11:654-61 pubmed publisher
    The parabasalid protist Trichomonas vaginalis is a widespread parasite that affects humans, frequently causing vaginitis in infected women...
  32. Munson E, Kramme T, Napierala M, Munson K, Miller C, Hryciuk J. Female epidemiology of transcription-mediated amplification-based Trichomonas vaginalis detection in a metropolitan setting with a high prevalence of sexually transmitted infection. J Clin Microbiol. 2012;50:3927-31 pubmed publisher
    Recent literature has reported increased accuracy of Trichomonas vaginalis transcription-mediated amplification (TMA)-based analyte-specific reagent (ASR) testing in female populations...
  33. Jones H, Lippman S, Caiaffa Filho H, Young T, van de Wijgert J. Performance of a rapid self-test for detection of Trichomonas vaginalis in South Africa and Brazil. J Clin Microbiol. 2013;51:1037-9 pubmed publisher
    ..in studies in Brazil (n = 695) and South Africa (n = 230) performed rapid point-of-care tests for Trichomonas vaginalis on self-collected vaginal swabs...
  34. Stoner K, Rabe L, Meyn L, Hillier S. Survival of Trichomonas vaginalis in wet preparation and on wet mount. Sex Transm Infect. 2013;89:485-8 pubmed publisher
    Microscopy is an insensitive method for detection of Trichomonas vaginalis, but is widely used because it is both rapid and inexpensive...
  35. Paschinger K, Hykollari A, Razzazi Fazeli E, Greenwell P, Leitsch D, Walochnik J, et al. The N-glycans of Trichomonas vaginalis contain variable core and antennal modifications. Glycobiology. 2012;22:300-13 pubmed publisher
    ..spectrometric and high-performance liquid chromatography data about the N-glycans of different strains of Trichomonas vaginalis, a parasite of the human reproductive tract...
  36. Meza Cervantez P, González Robles A, Cárdenas Guerra R, Ortega Lopez J, Saavedra E, Pineda E, et al. Pyruvate:ferredoxin oxidoreductase (PFO) is a surface-associated cell-binding protein in Trichomonas vaginalis and is involved in trichomonal adherence to host cells. Microbiology. 2011;157:3469-82 pubmed publisher
    The Trichomonas vaginalis 120 kDa protein adhesin (AP120) is induced under iron-rich conditions and has sequence homology with pyruvate:ferredoxin oxidoreductase A (PFO A), a hydrogenosomal enzyme that is absent in humans...
  37. Groom H, Warren A, Neal D, Bishop K. No evidence for infection of UK prostate cancer patients with XMRV, BK virus, Trichomonas vaginalis or human papilloma viruses. PLoS ONE. 2012;7:e34221 pubmed publisher
    ..In addition, a further 100 prostate DNA samples were tested for XMRV, BK virus, Trichomonas vaginalis and human papilloma viruses by nucleic acid detection techniques...
  38. Quinlivan E, Patel S, Grodensky C, Golin C, Tien H, Hobbs M. Modeling the impact of Trichomonas vaginalis infection on HIV transmission in HIV-infected individuals in medical care. Sex Transm Dis. 2012;39:671-7 pubmed
    To assess factors associated with having a Trichomonas vaginalis (TV) infection among persons receiving care for human immunodeficiency virus (HIV) and estimate the number of transmitted HIV infections attributable to TV.
  39. Brotman R, Bradford L, Conrad M, Gajer P, Ault K, Peralta L, et al. Association between Trichomonas vaginalis and vaginal bacterial community composition among reproductive-age women. Sex Transm Dis. 2012;39:807-12 pubmed
    ..We sought to evaluate the relationship between vaginal bacterial composition and Trichomonas vaginalis. Self-collected vaginal swabs were obtained cross-sectionally from 394 women equally representing 4 ethnic/..
  40. Meade J, Carlton J. Genetic diversity in Trichomonas vaginalis. Sex Transm Infect. 2013;89:444-8 pubmed publisher
    Recent advances in genetic characterisation of Trichomonas vaginalis isolates show that the extensive clinical variability in trichomoniasis and its disease sequelae are matched by significant genetic diversity in the organism itself, ..
  41. Mentel M, Zimorski V, Haferkamp P, Martin W, Henze K. Protein import into hydrogenosomes of Trichomonas vaginalis involves both N-terminal and internal targeting signals: a case study of thioredoxin reductases. Eukaryot Cell. 2008;7:1750-7 pubmed publisher
    The parabasalian flagellate Trichomonas vaginalis harbors mitochondrion-related and H(2)-producing organelles of anaerobic ATP synthesis, called hydrogenosomes, which harbor oxygen-sensitive enzymes essential to its pyruvate metabolism...
  42. Smutná T, Gonçalves V, Saraiva L, Tachezy J, Teixeira M, Hrdy I. Flavodiiron protein from Trichomonas vaginalis hydrogenosomes: the terminal oxygen reductase. Eukaryot Cell. 2009;8:47-55 pubmed publisher
    b>Trichomonas vaginalis is one of a few eukaryotes that have been found to encode several homologues of flavodiiron proteins (FDPs)...
  43. Torres Romero J, Arroyo R. Responsiveness of Trichomonas vaginalis to iron concentrations: evidence for a post-transcriptional iron regulation by an IRE/IRP-like system. Infect Genet Evol. 2009;9:1065-74 pubmed publisher
    b>Trichomonas vaginalis has high iron-dependency, favoring its growth and multiplication in culture. Iron also regulates some of the trichomonal virulence properties by yet unknown mechanisms...
  44. Leon S, Konda K, Bernstein K, Pajuelo J, Rosasco A, Caceres C, et al. Trichomonas vaginalis infection and associated risk factors in a socially-marginalized female population in coastal Peru. Infect Dis Obstet Gynecol. 2009;2009:752437 pubmed publisher
    The epidemiology of Trichomonas vaginalis infection among sexually active socially-marginalized women in three urban, coastal Peruvian cities was examined in order to quantify the prevalence of trichomonas infection and identify ..
  45. Upcroft J, Dunn L, Wal T, Tabrizi S, Delgadillo Correa M, Johnson P, et al. Metronidazole resistance in Trichomonas vaginalis from highland women in Papua New Guinea. Sex Health. 2009;6:334-8 pubmed publisher
    The prevalence of the sexually transmissible protozoan parasite Trichomonas vaginalis in the highlands of Papua New Guinea (PNG) has been reported to be as high as 46% and although not previously studied in Papua New Guinea, clinical ..
  46. Morada M, Smid O, Hampl V, Sutak R, Lam B, Rappelli P, et al. Hydrogenosome-localization of arginine deiminase in Trichomonas vaginalis. Mol Biochem Parasitol. 2011;176:51-4 pubmed publisher
    ..Subcellular localization of the ADH pathway enzymes in Trichomonas vaginalis revealed that arginine deiminase (ADI) localizes to the hydrogenosome, a mitochondrion-like organelle of ..
  47. Bachmann L, Hobbs M, Sena A, Sobel J, Schwebke J, Krieger J, et al. Trichomonas vaginalis genital infections: progress and challenges. Clin Infect Dis. 2011;53 Suppl 3:S160-72 pubmed publisher
    b>Trichomonas vaginalis (TV) infection is the most prevalent curable sexually transmitted infection in the United States and worldwide...
  48. Nam Y, Min A, Kim S, Lee Y, Kim K, Song K, et al. Leukotriene B(4) receptors BLT1 and BLT2 are involved in interleukin-8 production in human neutrophils induced by Trichomonas vaginalis-derived secretory products. Inflamm Res. 2012;61:97-102 pubmed publisher
    b>Trichomonas vaginalis is a flagellated protozoan parasite that causes human trichomoniasis. Although T...
  49. Conrad M, Bradić M, Warring S, Gorman A, Carlton J. Getting trichy: tools and approaches to interrogating Trichomonas vaginalis in a post-genome world. Trends Parasitol. 2013;29:17-25 pubmed publisher
    b>Trichomonas vaginalis is a parasite of the urogenital tract in men and women, with a worldwide presence and significant implications for global public health. T...
  50. Meade J, de Mestral J, Stiles J, Secor W, Finley R, Cleary J, et al. Genetic diversity of Trichomonas vaginalis clinical isolates determined by EcoRI restriction fragment length polymorphism of heat-shock protein 70 genes. Am J Trop Med Hyg. 2009;80:245-51 pubmed
    ..protein 70 (Hsp70) hybridization probe with EcoRI-digested genomic DNA was used in molecular typing of 129 Trichomonas vaginalis isolates...
  51. Lee K, Kim J, Jung M, Arii T, Ryu J, Han S. Three-dimensional structure of the cytoskeleton in Trichomonas vaginalis revealed new features. J Electron Microsc (Tokyo). 2009;58:305-13 pubmed publisher
    The flagellated protozoan Trichomonas vaginalis has been widely studied owing to its medical significance and unique structure. The complicated three-dimensional (3D) structure of the cellular components of T...
  52. Leitsch D, Kolarich D, Duchene M. The flavin inhibitor diphenyleneiodonium renders Trichomonas vaginalis resistant to metronidazole, inhibits thioredoxin reductase and flavin reductase, and shuts off hydrogenosomal enzymatic pathways. Mol Biochem Parasitol. 2010;171:17-24 pubmed publisher
    Infections with the microaerophilic protozoan parasite Trichomonas vaginalis are commonly treated with metronidazole, a 5-nitroimidazole drug...
  53. Ryan C, de Miguel N, Johnson P. Trichomonas vaginalis: current understanding of host-parasite interactions. Essays Biochem. 2011;51:161-75 pubmed publisher
    b>Trichomonas vaginalis is a sexually transmitted obligate extracellular parasite that colonizes the human urogenital tract...
  54. Hirt R, de Miguel N, Nakjang S, Dessi D, Liu Y, Diaz N, et al. Trichomonas vaginalis pathobiology new insights from the genome sequence. Adv Parasitol. 2011;77:87-140 pubmed publisher
    The draft genome of the common sexually transmitted pathogen Trichomonas vaginalis encodes one of the largest known proteome with 60,000 candidate proteins...
  55. Conrad M, Gorman A, Schillinger J, Fiori P, Arroyo R, Malla N, et al. Extensive genetic diversity, unique population structure and evidence of genetic exchange in the sexually transmitted parasite Trichomonas vaginalis. PLoS Negl Trop Dis. 2012;6:e1573 pubmed publisher
    b>Trichomonas vaginalis is the causative agent of human trichomoniasis, the most common non-viral sexually transmitted infection world-wide...
  56. Crucitti T, Abdellati S, Van Dyck E, Buve A. Molecular typing of the actin gene of Trichomonas vaginalis isolates by PCR-restriction fragment length polymorphism. Clin Microbiol Infect. 2008;14:844-52 pubmed publisher
    Human trichomoniasis, caused by the protozoan Trichomonas vaginalis, is a highly prevalent sexually transmitted infection. However, little is known about the degree of strain variability of T. vaginalis...
  57. Munson E, Napierala M, Olson R, Endes T, Block T, Hryciuk J, et al. Impact of Trichomonas vaginalis transcription-mediated amplification-based analyte-specific-reagent testing in a metropolitan setting of high sexually transmitted disease prevalence. J Clin Microbiol. 2008;46:3368-74 pubmed publisher
    ..and a metropolitan outpatient physician group were subjected to transcription-mediated amplification-based Trichomonas vaginalis analyte-specific-reagent (ASR) testing (Gen-Probe, Inc.). The rate of positive molecular ASR results (14...
  58. Schwebke J, Hobbs M, Taylor S, Sena A, Catania M, Weinbaum B, et al. Molecular testing for Trichomonas vaginalis in women: results from a prospective U.S. clinical trial. J Clin Microbiol. 2011;49:4106-11 pubmed publisher
    ..Nucleic acid amplification tests for Trichomonas vaginalis have improved sensitivity for detecting infected individuals compared to existing culture-based methods...
  59. Lin M, Hui C, Chen J, Wu J. The antimicrobial peptide, shrimp anti-lipopolysaccharide factor (SALF), inhibits proinflammatory cytokine expressions through the MAPK and NF-?B pathways in Trichomonas vaginalis adherent to HeLa cells. Peptides. 2012;38:197-207 pubmed publisher
    b>Trichomonas vaginalis is a parasitic protozoan that causes sexually transmitted infections (STIs) worldwide. The infection is dangerous and easily spreads within a community. Also, some cases of drug resistance were reported...
  60. Guschina I, Harris K, Maskrey B, Goldberg B, Lloyd D, Harwood J. The microaerophilic flagellate, Trichomonas vaginalis, contains unusual acyl lipids but no detectable cardiolipin. J Eukaryot Microbiol. 2009;56:52-7 pubmed publisher
    ..Here we report a careful lipid analysis of the sexually transmitted protist Trichomonas vaginalis. Major lipids were phosphatidylethanolamine (42%) and phosphatidylcholine (20%) with lesser amounts of ..
  61. Noel C, Diaz N, Sicheritz Ponten T, Safarikova L, Tachezy J, Tang P, et al. Trichomonas vaginalis vast BspA-like gene family: evidence for functional diversity from structural organisation and transcriptomics. BMC Genomics. 2010;11:99 pubmed publisher
    b>Trichomonas vaginalis is the most common non-viral human sexually transmitted pathogen and importantly, contributes to facilitating the spread of HIV...
  62. Perazzi B, Menghi C, Coppolillo E, Gatta C, Eliseth M, de Torres R, et al. Prevalence and comparison of diagnostic methods for Trichomonas vaginalis infection in pregnant women in Argentina. Korean J Parasitol. 2010;48:61-5 pubmed publisher
    ..The investigation of Trichomonas vaginalis was made by different microscopic examinations, and culture on liquid medium...
  63. Munson E, Napierala M, Basile J, Miller C, Burtch J, Hryciuk J, et al. Trichomonas vaginalis transcription-mediated amplification-based analyte-specific reagent and alternative target testing of primary clinical vaginal saline suspensions. Diagn Microbiol Infect Dis. 2010;68:66-72 pubmed publisher
    ..saline suspensions were aliquoted to lysis medium for transcription-mediated amplification (TMA)-based Trichomonas vaginalis analyte-specific reagent testing (ASR) (Gen-Probe, San Diego, CA). Specimens with visible T...
  64. Chen X, Penny D, Collins L. Characterization of RNase MRP RNA and novel snoRNAs from Giardia intestinalis and Trichomonas vaginalis. BMC Genomics. 2011;12:550 pubmed publisher
    ..In this study we have conducted a genome-scale survey of medium-length ncRNAs from the protozoan parasites Giardia intestinalis and Trichomonas vaginalis.
  65. Leitsch D, Drinić M, Kolarich D, Duchene M. Down-regulation of flavin reductase and alcohol dehydrogenase-1 (ADH1) in metronidazole-resistant isolates of Trichomonas vaginalis. Mol Biochem Parasitol. 2012;183:177-83 pubmed publisher
    The microaerophilic parasite Trichomonas vaginalis is a causative agent of painful vaginitis or urethritis, termed trichomoniasis, and can also cause preterm delivery or stillbirth...
  66. Yeh Y, Huang K, Richie Gan R, Huang H, Wang T, Tang P. Phosphoproteome profiling of the sexually transmitted pathogen Trichomonas vaginalis. J Microbiol Immunol Infect. 2013;46:366-73 pubmed publisher
    Trichomoniasis caused by Trichomonas vaginalis is the most common non-viral sexually transmitted infection. Morphological transformation from the trophozoite stage to the amoeboid or pseudocyst stage is crucial for T...
  67. Sobngwi Tambekou J, Taljaard D, Nieuwoudt M, Lissouba P, Puren A, Auvert B. Male circumcision and Neisseria gonorrhoeae, Chlamydia trachomatis and Trichomonas vaginalis: observations after a randomised controlled trial for HIV prevention. Sex Transm Infect. 2009;85:116-20 pubmed publisher
    To assess the association between male circumcision and Neisseria gonorrhoeae, Chlamydia trachomatis and Trichomonas vaginalis using data from a male circumcision randomised controlled trial.
  68. Karaman U, Karadag N, Atambay M, Arserim Kaya N, Daldal N. A comparison of cytological and parasitological methods in the diagnosis of Trichomonas vaginalis. Turkiye Parazitol Derg. 2008;32:309-12 pubmed
    b>Trichomonas vaginalis (T. vaginalis), which causes urogenital system infections in humans, develops symptomatically and asymptomatically. T...
  69. Infante V, Miranda Olvera A, De Leon Rodriguez L, Anaya Velazquez F, Rodriguez M, Avila E. Effect of the antimicrobial peptide tritrpticin on the in vitro viability and growth of Trichomonas vaginalis. Curr Microbiol. 2011;62:301-6 pubmed publisher
    ..amino acid tryptophan-rich antimicrobial peptide derived from a porcine cathelicidin, was tested against Trichomonas vaginalis, a protozoan that causes a serious non-viral sexually transmitted disease associated with preterm birth, ..
  70. Ramón Luing L, Rendón Gandarilla F, Puente Rivera J, Avila González L, Arroyo R. Identification and characterization of the immunogenic cytotoxic TvCP39 proteinase gene of Trichomonas vaginalis. Int J Biochem Cell Biol. 2011;43:1500-11 pubmed publisher
    TvCP39 is a 39 kDa cysteine proteinase (CP) involved in Trichomonas vaginalis cytotoxicity that has been found in vaginal secretions and is immunogenic in patients with trichomonosis...
  71. Ryan C, Mehlert A, Richardson J, Ferguson M, Johnson P. Chemical structure of Trichomonas vaginalis surface lipoglycan: a role for short galactose (?1-4/3) N-acetylglucosamine repeats in host cell interaction. J Biol Chem. 2011;286:40494-508 pubmed publisher
    The extracellular parasite Trichomonas vaginalis contains a surface glycoconjugate that appears to mediate parasite-host cell interaction via binding to human galectin-1...
  72. Haseen F, Chawdhury F, Hossain M, Huq M, Bhuiyan M, Imam H, et al. Sexually transmitted infections and sexual behaviour among youth clients of hotel-based female sex workers in Dhaka, Bangladesh. Int J STD AIDS. 2012;23:553-9 pubmed publisher
    ..before sex) and blood were collected for diagnosis of Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, syphilis and herpes simplex virus 2 (HSV2) infection...
  73. Stemmer S, Adelson M, Trama J, Dorak M, Mordechai E. Detection rates of trichomonas vaginalis, in different age groups, using real-time polymerase chain reaction. J Low Genit Tract Dis. 2012;16:352-7 pubmed publisher
    The study aimed to compare the overall detection rate of Trichomonas vaginalis to Chlamydia trachomatis and Neiserria gonorrhea and report detection rates by age groups.
  74. Piperaki E, Theodora M, Mendris M, Barbitsa L, Pitiriga V, Antsaklis A, et al. Prevalence of Trichomonas vaginalis infection in women attending a major gynaecological hospital in Greece: a cross-sectional study. J Clin Pathol. 2010;63:249-53 pubmed publisher
    The prevalence of Trichomonas vaginalis is not accurately estimated, since it is not a reportable disease.
  75. Krashin J, Koumans E, Bradshaw Sydnor A, Braxton J, Evan Secor W, Sawyer M, et al. Trichomonas vaginalis prevalence, incidence, risk factors and antibiotic-resistance in an adolescent population. Sex Transm Dis. 2010;37:440-4 pubmed publisher
    To determine the prevalence and incidence of trichomoniasis, risk factors for infection, and the prevalence of metronidazole and tinidazole-resistant Trichomonas vaginalis (T. vaginalis) in female adolescents.
  76. Vatanshenassan M, Rezaie S, Mohebali M, Niromand N, Kazemi B, Babaei Z, et al. Trichomonas vaginalis: investigation of a novel diagnostic method in urine samples using cysteine proteinase 4 gene and PCR technique. Exp Parasitol. 2010;126:187-90 pubmed publisher
    b>Trichomonas vaginalis is the agent of a highly prevalent sexually transmitted disease that leads to vaginitis, urethritis, ectocervicitis and has been associated with human immunodeficiency virus (HIV). Detection of T...
  77. Cui J, Das S, Smith T, Samuelson J. Trichomonas transmembrane cyclases result from massive gene duplication and concomitant development of pseudogenes. PLoS Negl Trop Dis. 2010;4:e782 pubmed publisher
    b>Trichomonas vaginalis has an unusually large genome (approximately 160 Mb) encoding approximately 60,000 proteins...
  78. Schwebke J, Rompalo A, Taylor S, Seña A, Martin D, Lopez L, et al. Re-evaluating the treatment of nongonococcal urethritis: emphasizing emerging pathogens--a randomized clinical trial. Clin Infect Dis. 2011;52:163-70 pubmed publisher
    Nongonococcal urethritis (NGU) is a common chlamydia-associated syndrome in men; however, Trichomonas vaginalis and Mycoplasma genitalium are associated with its etiology and should be considered in approaches to therapy...
  79. Rada P, Dolezal P, Jedelský P, Bursac D, Perry A, Sedinová M, et al. The core components of organelle biogenesis and membrane transport in the hydrogenosomes of Trichomonas vaginalis. PLoS ONE. 2011;6:e24428 pubmed publisher
    b>Trichomonas vaginalis is a parasitic protist of the Excavata group...
  80. Cobo E, Eckmann L, Corbeil L. Murine models of vaginal trichomonad infections. Am J Trop Med Hyg. 2011;85:667-73 pubmed publisher
    b>Trichomonas vaginalis and Tritrichomonas foetus cause common sexually transmitted infections in humans and cattle, respectively. Mouse models of trichomoniasis are important for pathogenic and therapeutic studies...
  81. Hirt R. Trichomonas vaginalis virulence factors: an integrative overview. Sex Transm Infect. 2013;89:439-43 pubmed publisher
    The elusive nature of Trichomonas vaginalis, the most common, non-viral, sexually transmitted pathogen has hampered our knowledge of its significance for human health for over 150 years...
  82. Hsu H, Ong S, Lee M, Tai J. Transcriptional regulation of an iron-inducible gene by differential and alternate promoter entries of multiple Myb proteins in the protozoan parasite Trichomonas vaginalis. Eukaryot Cell. 2009;8:362-72 pubmed publisher
    Iron-inducible transcription of a malic enzyme gene (also reputed to be ap65-1) in Trichomonas vaginalis was previously shown to involve a Myb1 repressor and a Myb2 activator, each of which may preferentially select two closely spaced ..
  83. Goldman L, Upcroft J, Workowski K, Rapkin A. Treatment of metronidazole-resistant Trichomonas vaginalis. Sex Health. 2009;6:345-7 pubmed publisher
    ..In vitro susceptibility testing revealed the patient's Trichomonas vaginalis isolate was highly resistant to both metronidazole and tinidazole...
  84. Noel J, Fayt I, Romero Munoz M, Simon P, Engohan Aloghe C. High prevalence of high-risk human papillomavirus infection among women with Trichomonas vaginalis infection on monolayer cytology. Arch Gynecol Obstet. 2010;282:503-5 pubmed publisher
    To evaluate the risk of high-risk human papillomavirus (HPV) infection in women with Trichomonas vaginalis infection, and the reason remains unclear.
  85. Burstein D, Gould S, Zimorski V, Kloesges T, Kiosse F, Major P, et al. A machine learning approach to identify hydrogenosomal proteins in Trichomonas vaginalis. Eukaryot Cell. 2012;11:217-28 pubmed publisher
    The protozoan parasite Trichomonas vaginalis is the causative agent of trichomoniasis, the most widespread nonviral sexually transmitted disease in humans...
  86. Frasson A, Dos Santos O, Duarte M, da Silva Trentin D, Giordani R, da Silva A, et al. First report of anti-Trichomonas vaginalis activity of the medicinal plant Polygala decumbens from the Brazilian semi-arid region, Caatinga. Parasitol Res. 2012;110:2581-7 pubmed publisher
    Trichomonosis, caused by the flagellate protozoan Trichomonas vaginalis, is the most common non-viral sexually transmitted disease worldwide. Actually, the infection treatment is based on 5-nitroimidazole drugs...
  87. Munson K, Napierala M, Munson E, Schell R, Kramme T, Miller C, et al. Screening of male patients for Trichomonas vaginalis with transcription-mediated amplification in a community with a high prevalence of sexually transmitted infection. J Clin Microbiol. 2013;51:101-4 pubmed publisher
    b>Trichomonas vaginalis infection in males has been largely uncharacterized...
  88. Grama D, Casarotti L, Morato M, Silva L, Mendonça D, Limongi J, et al. Prevalence of Trichomonas vaginalis and risk factors in women treated at public health units in Brazil: a transversal study. Trans R Soc Trop Med Hyg. 2013;107:584-91 pubmed publisher
    Studies have revealed high prevalence rates of Trichomonas vaginalis in men and women worldwide. In Brazil, where reporting is not mandatory, the true prevalence rate is unknown...
  89. Aurrecoechea C, Brestelli J, Brunk B, Carlton J, Dommer J, Fischer S, et al. GiardiaDB and TrichDB: integrated genomic resources for the eukaryotic protist pathogens Giardia lamblia and Trichomonas vaginalis. Nucleic Acids Res. 2009;37:D526-30 pubmed publisher
    ..org) and TrichDB (http://TrichDB.org) house the genome databases for Giardia lamblia and Trichomonas vaginalis, respectively, and represent the latest additions to the EuPathDB (http://EuPathDB...
  90. Fichorova R. Impact of T. vaginalis infection on innate immune responses and reproductive outcome. J Reprod Immunol. 2009;83:185-9 pubmed publisher
    b>Trichomonas vaginalis is the most common non-viral sexually transmitted pathogen...
  91. de Miguel N, Lustig G, Twu O, Chattopadhyay A, Wohlschlegel J, Johnson P. Proteome analysis of the surface of Trichomonas vaginalis reveals novel proteins and strain-dependent differential expression. Mol Cell Proteomics. 2010;9:1554-66 pubmed publisher
    ..and multidimensional protein identification technology to identify the surface proteome of six strains of Trichomonas vaginalis with differing adherence capacities to vaginal epithelial cells...
  92. Hernández Romano P, Hernandez R, Arroyo R, Alderete J, López Villaseñor I. Identification and characterization of a surface-associated, subtilisin-like serine protease in Trichomonas vaginalis. Parasitology. 2010;137:1621-35 pubmed publisher
    b>Trichomonas vaginalis is a protozoan parasite causing trichomonosis, a sexually transmitted infection in humans...