candida glabrata

Summary

Summary: A species of MITOSPORIC FUNGI commonly found on the body surface. It causes opportunistic infections especially in immunocompromised patients.

Top Publications

  1. Thierry A, Dujon B, Richard G. Megasatellites: a new class of large tandem repeats discovered in the pathogenic yeast Candida glabrata. Cell Mol Life Sci. 2010;67:671-6 pubmed publisher
    Megasatellites are DNA tandem arrays made of large motifs; they were discovered in the yeast Candida glabrata. They are widespread in this species (40 copies) but are not found in any other hemiascomycete so far, raising the intriguing ..
  2. Keppler Ross S, Douglas L, Konopka J, Dean N. Recognition of yeast by murine macrophages requires mannan but not glucan. Eukaryot Cell. 2010;9:1776-87 pubmed publisher
    ..b>Candida glabrata and Saccharomyces cerevisiae are taken up by J774 macrophage cells more rapidly than C. albicans, and C...
  3. Baltch A, Lawrence D, Ritz W, Andersen N, Bopp L, Michelsen P, et al. Effects of echinocandins on cytokine/chemokine production by human monocytes activated by infection with Candida glabrata or by lipopolysaccharide. Diagn Microbiol Infect Dis. 2012;72:226-33 pubmed publisher
    Serious Candida glabrata infections, which can be difficult to treat, are often treated with echinocandins...
  4. Henrich B, Schmitt M, Bergmann N, Zanger K, Kubitz R, Haussinger D, et al. Mycoplasma salivarium detected in a microbial community with Candida glabrata in the biofilm of an occluded biliary stent. J Med Microbiol. 2010;59:239-41 pubmed publisher
    ..We describe here, for what is believed to be the first time, the detection of M. salivarium, together with Candida glabrata, in an occluded biliary stent of an icteric, cholestatic patient.
  5. Paul S, Schmidt J, Moye Rowley W. Regulation of the CgPdr1 transcription factor from the pathogen Candida glabrata. Eukaryot Cell. 2011;10:187-97 pubmed publisher
    b>Candida glabrata is an opportunistic human pathogen that is increasingly associated with candidemia, owing in part to the intrinsic and acquired high tolerance the organism exhibits for the important clinical antifungal drug fluconazole...
  6. Borah S, Shivarathri R, Kaur R. The Rho1 GTPase-activating protein CgBem2 is required for survival of azole stress in Candida glabrata. J Biol Chem. 2011;286:34311-24 pubmed publisher
    ..b>Candida glabrata, the second/third most common cause of candidemia, shows reduced susceptibility to a widely used antifungal ..
  7. Shin J, Chae M, Song J, Jung S, Cho D, Kee S, et al. Changes in karyotype and azole susceptibility of sequential bloodstream isolates from patients with Candida glabrata candidemia. J Clin Microbiol. 2007;45:2385-91 pubmed
    We examined the changes in genotypes and azole susceptibilities among sequential bloodstream isolates of Candida glabrata during the course of fungemia and the relationship of these changes to antifungal therapy...
  8. Hess D, Henry Stanley M, Bendel C, Zhang B, Johnson M, Wells C. Escherichia coli and TNF-alpha modulate macrophage phagocytosis of Candida glabrata. J Surg Res. 2009;155:217-24 pubmed publisher
    ..coli LPS and TNF-alpha may participate in host defense against C. glabrata by a mechanism involving increased macrophage phagocytosis, suggesting that stimulation of inflammatory cytokines may facilitate host clearance of C. glabrata. ..
  9. Caldwell M, Perfect J, Carlson A, Proia A. Candida glabrata endophthalmitis following penetrating keratoplasty. J Cataract Refract Surg. 2009;35:598-602 pubmed publisher
    We report a case of Candida glabrata endophthalmitis following penetrating keratoplasty in a 57-year-old man...
  10. Polakova S, Blume C, Zárate J, Mentel M, Jørck Ramberg D, Stenderup J, et al. Formation of new chromosomes as a virulence mechanism in yeast Candida glabrata. Proc Natl Acad Sci U S A. 2009;106:2688-93 pubmed publisher
    ..Here, we analyzed 40 pathogenic isolates of a haploid and asexual yeast, Candida glabrata, for their genome structure and stability...

Detail Information

Publications92

  1. Thierry A, Dujon B, Richard G. Megasatellites: a new class of large tandem repeats discovered in the pathogenic yeast Candida glabrata. Cell Mol Life Sci. 2010;67:671-6 pubmed publisher
    Megasatellites are DNA tandem arrays made of large motifs; they were discovered in the yeast Candida glabrata. They are widespread in this species (40 copies) but are not found in any other hemiascomycete so far, raising the intriguing ..
  2. Keppler Ross S, Douglas L, Konopka J, Dean N. Recognition of yeast by murine macrophages requires mannan but not glucan. Eukaryot Cell. 2010;9:1776-87 pubmed publisher
    ..b>Candida glabrata and Saccharomyces cerevisiae are taken up by J774 macrophage cells more rapidly than C. albicans, and C...
  3. Baltch A, Lawrence D, Ritz W, Andersen N, Bopp L, Michelsen P, et al. Effects of echinocandins on cytokine/chemokine production by human monocytes activated by infection with Candida glabrata or by lipopolysaccharide. Diagn Microbiol Infect Dis. 2012;72:226-33 pubmed publisher
    Serious Candida glabrata infections, which can be difficult to treat, are often treated with echinocandins...
  4. Henrich B, Schmitt M, Bergmann N, Zanger K, Kubitz R, Haussinger D, et al. Mycoplasma salivarium detected in a microbial community with Candida glabrata in the biofilm of an occluded biliary stent. J Med Microbiol. 2010;59:239-41 pubmed publisher
    ..We describe here, for what is believed to be the first time, the detection of M. salivarium, together with Candida glabrata, in an occluded biliary stent of an icteric, cholestatic patient.
  5. Paul S, Schmidt J, Moye Rowley W. Regulation of the CgPdr1 transcription factor from the pathogen Candida glabrata. Eukaryot Cell. 2011;10:187-97 pubmed publisher
    b>Candida glabrata is an opportunistic human pathogen that is increasingly associated with candidemia, owing in part to the intrinsic and acquired high tolerance the organism exhibits for the important clinical antifungal drug fluconazole...
  6. Borah S, Shivarathri R, Kaur R. The Rho1 GTPase-activating protein CgBem2 is required for survival of azole stress in Candida glabrata. J Biol Chem. 2011;286:34311-24 pubmed publisher
    ..b>Candida glabrata, the second/third most common cause of candidemia, shows reduced susceptibility to a widely used antifungal ..
  7. Shin J, Chae M, Song J, Jung S, Cho D, Kee S, et al. Changes in karyotype and azole susceptibility of sequential bloodstream isolates from patients with Candida glabrata candidemia. J Clin Microbiol. 2007;45:2385-91 pubmed
    We examined the changes in genotypes and azole susceptibilities among sequential bloodstream isolates of Candida glabrata during the course of fungemia and the relationship of these changes to antifungal therapy...
  8. Hess D, Henry Stanley M, Bendel C, Zhang B, Johnson M, Wells C. Escherichia coli and TNF-alpha modulate macrophage phagocytosis of Candida glabrata. J Surg Res. 2009;155:217-24 pubmed publisher
    ..coli LPS and TNF-alpha may participate in host defense against C. glabrata by a mechanism involving increased macrophage phagocytosis, suggesting that stimulation of inflammatory cytokines may facilitate host clearance of C. glabrata. ..
  9. Caldwell M, Perfect J, Carlson A, Proia A. Candida glabrata endophthalmitis following penetrating keratoplasty. J Cataract Refract Surg. 2009;35:598-602 pubmed publisher
    We report a case of Candida glabrata endophthalmitis following penetrating keratoplasty in a 57-year-old man...
  10. Polakova S, Blume C, Zárate J, Mentel M, Jørck Ramberg D, Stenderup J, et al. Formation of new chromosomes as a virulence mechanism in yeast Candida glabrata. Proc Natl Acad Sci U S A. 2009;106:2688-93 pubmed publisher
    ..Here, we analyzed 40 pathogenic isolates of a haploid and asexual yeast, Candida glabrata, for their genome structure and stability...
  11. Silva S, Negri M, Henriques M, Oliveira R, Williams D, Azeredo J. Candida glabrata, Candida parapsilosis and Candida tropicalis: biology, epidemiology, pathogenicity and antifungal resistance. FEMS Microbiol Rev. 2012;36:288-305 pubmed publisher
    ..Candida albicans is the main cause of candidosis; however, non-C. albicans Candida (NCAC) species such as Candida glabrata, Candida tropicalis and Candida parapsilosis are now frequently identified as human pathogens...
  12. Culakova H, Dzugasova V, Perzelova J, Gbelska Y, Subik J. Mutation of the CgPDR16 gene attenuates azole tolerance and biofilm production in pathogenic Candida glabrata. Yeast. 2013;30:403-14 pubmed publisher
    ..analysis of the CgPDR16 gene, whose mutation has been previously shown to enhance fluconazole sensitivity in Candida glabrata mutant cells. We have cloned the CgPDR16 gene, which was able to complement the pdr16? mutation in both C...
  13. Buitrón García Figueroa R, Araiza Santibáñez J, Basurto Kuba E, Bonifaz Trujillo A. Candida glabrata: an emergent opportunist in vulvovaginitis. Cir Cir. 2009;77:423-7 pubmed
    ..2% on NCLSI method with a MIC of 16 microg/ml. The frequency of Candida glabrata has increased over the past years...
  14. Silva S, Henriques M, Hayes A, Oliveira R, Azeredo J, Williams D. Candida glabrata and Candida albicans co-infection of an in vitro oral epithelium. J Oral Pathol Med. 2011;40:421-7 pubmed publisher
    Candida albicans is regarded as the leading of candidosis. However, Candida glabrata has emerged as an important pathogen of oral mucosa, occurring both singly or in mixed species infections, often with C. albicans. Compared with C...
  15. Zhang X, Yu S, Yu J, Gong Y, Feng W, Sun F. Retrospective analysis of epidemiology and prognostic factors for candidemia at a hospital in China, 2000-2009. Jpn J Infect Dis. 2012;65:510-5 pubmed
    ..albicans were the major factors associated with mortality. This study highlights the importance of considering the possibility of invasive Candida infection in patients exposed to these risk factors. ..
  16. Li Q, Skinner J, Bennett J. Evaluation of reference genes for real-time quantitative PCR studies in Candida glabrata following azole treatment. BMC Mol Biol. 2012;13:22 pubmed publisher
    ..to identify reference genes as internal controls for gene expression studies by RT-qPCR in azole-stimulated Candida glabrata. The expression stability of 16 reference genes under fluconazole stress was evaluated using fold change and ..
  17. Enache Angoulvant A, Bourget M, Brisse S, Stockman Pannier C, Diancourt L, Francois N, et al. Multilocus microsatellite markers for molecular typing of Candida glabrata: application to analysis of genetic relationships between bloodstream and digestive system isolates. J Clin Microbiol. 2010;48:4028-34 pubmed publisher
    b>Candida glabrata has emerged as the second most common etiologic agent, after Candida albicans, of superficial and invasive candidiasis in adults...
  18. Ahmad K, Ishchuk O, Hellborg L, Jørgensen G, Skvarc M, Stenderup J, et al. Small chromosomes among Danish Candida glabrata isolates originated through different mechanisms. Antonie Van Leeuwenhoek. 2013;104:111-22 pubmed publisher
    We analyzed 192 strains of the pathogenic yeast Candida glabrata from patients, mainly suffering from systemic infection, at Danish hospitals during 1985-1999...
  19. Yu E, Sun J, Lei M, Lue N. Analyses of Candida Cdc13 orthologues revealed a novel OB fold dimer arrangement, dimerization-assisted DNA binding, and substantial structural differences between Cdc13 and RPA70. Mol Cell Biol. 2012;32:186-98 pubmed publisher
    ..Our findings provide new insights on the mechanisms and evolution of a critical telomere end binding protein. ..
  20. Noble J, Tsai H, Suffis S, Su Q, Myers T, Bennett J. STB5 is a negative regulator of azole resistance in Candida glabrata. Antimicrob Agents Chemother. 2013;57:959-67 pubmed publisher
    The opportunistic yeast pathogen Candida glabrata is recognized for its ability to acquire resistance during prolonged treatment with azole antifungals (J. E. Bennett, K. Izumikawa, and K. A. Marr. Antimicrob. Agents Chemother...
  21. Sanguinetti M, Posteraro B, Fiori B, Ranno S, Torelli R, Fadda G. Mechanisms of azole resistance in clinical isolates of Candida glabrata collected during a hospital survey of antifungal resistance. Antimicrob Agents Chemother. 2005;49:668-79 pubmed
    The increasing use of azole antifungals for the treatment of mucosal and systemic Candida glabrata infections has resulted in the selection and/or emergence of resistant strains...
  22. Namiki Y, Ueno K, Mitani H, Virtudazo E, Ohkusu M, Shimizu K, et al. Scanning and negative-staining electron microscopy of protoplast regeneration of a wild-type and two chitin synthase mutants in the pathogenic yeast Candida glabrata. J Electron Microsc (Tokyo). 2011;60:157-65 pubmed publisher
    Protoplast regeneration of a wild-type and two mutant strains of Candida glabrata defective in CHS3 homologues encoding class IV chitin synthase in Saccharomyces cerevisiae was examined by scanning and negative-staining electron ..
  23. Miyazaki T, Inamine T, Yamauchi S, Nagayoshi Y, Saijo T, Izumikawa K, et al. Role of the Slt2 mitogen-activated protein kinase pathway in cell wall integrity and virulence in Candida glabrata. FEMS Yeast Res. 2010;10:343-52 pubmed publisher
    ..of SLT2 deletion and overexpression on drug susceptibility and virulence in the opportunistic fungal pathogen Candida glabrata. While the Deltaslt2 strain showed decreased tolerance to elevated temperature and cell wall-damaging agents, ..
  24. Gutiérrez Escobedo G, Orta Zavalza E, Castano I, De Las Peñas A. Role of glutathione in the oxidative stress response in the fungal pathogen Candida glabrata. Curr Genet. 2013;59:91-106 pubmed publisher
    b>Candida glabrata, an opportunistic fungal pathogen, accounts for 18-26 % of all Candida systemic infections in the US. C...
  25. Monteiro D, Silva S, Negri M, Gorup L, de Camargo E, Oliveira R, et al. Silver colloidal nanoparticles: effect on matrix composition and structure of Candida albicans and Candida glabrata biofilms. J Appl Microbiol. 2013;114:1175-83 pubmed publisher
    The aim of this study was to assess the effect of different silver nanoparticles (SN) concentrations on the matrix composition and structure of Candida albicans and Candida glabrata biofilms.
  26. Garcia Effron G, Lee S, Park S, Cleary J, Perlin D. Effect of Candida glabrata FKS1 and FKS2 mutations on echinocandin sensitivity and kinetics of 1,3-beta-D-glucan synthase: implication for the existing susceptibility breakpoint. Antimicrob Agents Chemother. 2009;53:3690-9 pubmed publisher
    Thirteen Candida glabrata strains harboring a range of mutations in hot spot regions of FKS1 and FKS2 were studied. The mutations were linked to an echinocandin reduced susceptibility phenotype...
  27. Pfaller M, Castanheira M, Lockhart S, Ahlquist A, Messer S, Jones R. Frequency of decreased susceptibility and resistance to echinocandins among fluconazole-resistant bloodstream isolates of Candida glabrata. J Clin Microbiol. 2012;50:1199-203 pubmed publisher
    ..of antifungal agents is considered to be the first-line treatment of bloodstream infections (BSI) due to Candida glabrata. Recent reports of BSI due to strains of C...
  28. Nagi M, Nakayama H, Tanabe K, Bard M, Aoyama T, Okano M, et al. Transcription factors CgUPC2A and CgUPC2B regulate ergosterol biosynthetic genes in Candida glabrata. Genes Cells. 2011;16:80-9 pubmed publisher
    ..We identified two UPC2/ECM22 homologues in the pathogenic fungus Candida glabrata which we designated CgUPC2A and CgUPC2B...
  29. Singh Babak S, Babak T, Diezmann S, Hill J, Xie J, Chen Y, et al. Global analysis of the evolution and mechanism of echinocandin resistance in Candida glabrata. PLoS Pathog. 2012;8:e1002718 pubmed publisher
    The evolution of drug resistance has a profound impact on human health. Candida glabrata is a leading human fungal pathogen that can rapidly evolve resistance to echinocandins, which target cell wall biosynthesis and are front-line ..
  30. Monteiro D, Gorup L, Silva S, Negri M, de Camargo E, Oliveira R, et al. Silver colloidal nanoparticles: antifungal effect against adhered cells and biofilms of Candida albicans and Candida glabrata. Biofouling. 2011;27:711-9 pubmed publisher
    The aim of this study was to evaluate the effect of silver nanoparticles (SN) against Candida albicans and Candida glabrata adhered cells and biofilms...
  31. Colombo A, Garnica M, Aranha Camargo L, Da Cunha C, Bandeira A, Borghi D, et al. Candida glabrata: an emerging pathogen in Brazilian tertiary care hospitals. Med Mycol. 2013;51:38-44 pubmed publisher
    b>Candida glabrata is an infrequent cause of candidemia in Brazilian public hospitals. We investigated putative differences in the epidemiology of candidemia in institutions with different sources of funding...
  32. Brunke S, Seider K, Almeida R, Heyken A, Fleck C, Brock M, et al. Candida glabrata tryptophan-based pigment production via the Ehrlich pathway. Mol Microbiol. 2010;76:25-47 pubmed publisher
    ..Here, we have dissected the biosynthetic pathway of a tryptophan-derived pigment of the human pathogen Candida glabrata, identified key genes involved in pigment production and have begun to elucidate the possible biological ..
  33. Kachouri Lafond R, Dujon B, Gilson E, Westhof E, Fairhead C, Teixeira M. Large telomerase RNA, telomere length heterogeneity and escape from senescence in Candida glabrata. FEBS Lett. 2009;583:3605-10 pubmed publisher
    ..Here, we characterize the telomerase subunits in the hemiascomycete yeast Candida glabrata. We propose a secondary structure model for the telomerase RNA that is the largest described to date...
  34. Seider K, Gerwien F, Kasper L, Allert S, Brunke S, Jablonowski N, et al. Immune evasion, stress resistance, and efficient nutrient acquisition are crucial for intracellular survival of Candida glabrata within macrophages. Eukaryot Cell. 2014;13:170-83 pubmed publisher
    b>Candida glabrata is both a human fungal commensal and an opportunistic pathogen which can withstand activities of the immune system. For example, C. glabrata can survive phagocytosis and replicates within macrophages...
  35. Chen T, Chen Y, Chen Y, Lu P. Fluconazole exposure rather than clonal spreading is correlated with the emergence of Candida glabrata with cross-resistance to triazole antifungal agents. Kaohsiung J Med Sci. 2012;28:306-15 pubmed publisher
    ..The cross-resistance to triazole among C. glabrata isolates was associated with previous fluconazole exposure as opposed to clonal spreading. Selection pressure due to fluconazole use may play a major role in triazole cross-resistance...
  36. Vandeputte P, Pineau L, Larcher G, Noel T, Brèthes D, Chabasse D, et al. Molecular mechanisms of resistance to 5-fluorocytosine in laboratory mutants of Candida glabrata. Mycopathologia. 2011;171:11-21 pubmed publisher
    Resistance to 5-fluorocytosine (5-FC) has been poorly investigated in the yeast Candida glabrata. This study was conducted on laboratory mutants obtained by exposure of a wild-type isolate to 5-FC...
  37. Ma B, Pan S, Domergue R, Rigby T, Whiteway M, Johnson D, et al. High-affinity transporters for NAD+ precursors in Candida glabrata are regulated by Hst1 and induced in response to niacin limitation. Mol Cell Biol. 2009;29:4067-79 pubmed publisher
    The yeast Candida glabrata is an opportunistic pathogen of humans. C. glabrata is a NAD(+) auxotroph, and its growth depends on the availability of niacin (environmental vitamin precursors of NAD(+))...
  38. Yamada E, Nishikawa H, Nomura N, Mitsuyama J. T-2307 shows efficacy in a murine model of Candida glabrata infection despite in vitro trailing growth phenomena. Antimicrob Agents Chemother. 2010;54:3630-4 pubmed publisher
    ..In our preliminary studies, Candida glabrata exhibited significant trailing growth (partial inhibition of growth over an extended range of antifungal ..
  39. Posteraro B, Martucci R, La Sorda M, Fiori B, Sanglard D, De Carolis E, et al. Reliability of the Vitek 2 yeast susceptibility test for detection of in vitro resistance to fluconazole and voriconazole in clinical isolates of Candida albicans and Candida glabrata. J Clin Microbiol. 2009;47:1927-30 pubmed publisher
    ..Excellent categorical agreement with the CLSI broth microdilution method was observed (97.5% for both the azoles). Moreover, the Vitek 2 system was able to identify all but 2 of 59 investigated fluconazole-resistant organisms...
  40. Monti S, Maresca A, Viparelli F, Carta F, De Simone G, Muhlschlegel F, et al. Dithiocarbamates are strong inhibitors of the beta-class fungal carbonic anhydrases from Cryptococcus neoformans, Candida albicans and Candida glabrata. Bioorg Med Chem Lett. 2012;22:859-62 pubmed publisher
    ..2.1.1) from the fungal pathogens Cryptococcus neoformans, Candida albicans and Candida glabrata, that is, Can2, CaNce103 and CgNce103, respectively...
  41. Ifrim D, Bain J, Reid D, Oosting M, Verschueren I, Gow N, et al. Role of Dectin-2 for host defense against systemic infection with Candida glabrata. Infect Immun. 2014;82:1064-73 pubmed publisher
    Although Candida glabrata is an important pathogenic Candida species, relatively little is known about its innate immune recognition. Here, we explore the potential role of Dectin-2 for host defense against C. glabrata...
  42. Halliwell S, Smith M, Muston P, Holland S, Avery S. Heterogeneous expression of the virulence-related adhesin Epa1 between individual cells and strains of the pathogen Candida glabrata. Eukaryot Cell. 2012;11:141-50 pubmed publisher
    ..the relevance of gene expression heterogeneity to virulence properties of a major fungal pathogen, Candida glabrata. The organism's key virulence-associated factors include glycosylphosphatidylinositol-anchored adhesins, ..
  43. Orta Zavalza E, Guerrero Serrano G, Gutiérrez Escobedo G, Cañas Villamar I, Juárez Cepeda J, Castano I, et al. Local silencing controls the oxidative stress response and the multidrug resistance in Candida glabrata. Mol Microbiol. 2013;88:1135-48 pubmed publisher
    In Candida glabrata, the sirtuins Sir2 and Hst1 control the expression of a wide number of genes including adhesins required for host colonization and niacin transporters needed for growth...
  44. Cobos Trigueros N, Morata L, Torres J, Zboromyrska Y, Soriano A, Pitart C, et al. Usefulness of time-to-positivity in aerobic and anaerobic vials to predict the presence of Candida glabrata in patients with candidaemia. J Antimicrob Chemother. 2013;68:2839-41 pubmed publisher
    To determine whether time-to-positivity (TTP) in aerobic and anaerobic blood culture vials is useful to predict the presence of Candida glabrata in patients with candidaemia.
  45. Tavanti A, Maisetta G, Del Gaudio G, Petruzzelli R, Sanguinetti M, Batoni G, et al. Fungicidal activity of the human peptide hepcidin 20 alone or in combination with other antifungals against Candida glabrata isolates. Peptides. 2011;32:2484-7 pubmed publisher
    b>Candida glabrata infections are often difficult to eradicate due to the intrinsically low susceptibility to azoles of this species. In addition, C...
  46. Kraneveld E, de Soet J, Deng D, Dekker H, de Koster C, Klis F, et al. Identification and differential gene expression of adhesin-like wall proteins in Candida glabrata biofilms. Mycopathologia. 2011;172:415-27 pubmed publisher
    ..initial step in biofilm development and subsequent establishment of fungal infections by the human pathogen Candida glabrata is adherence to a surface...
  47. Pärnänen P, Meurman J, Samaranayake L, Virtanen I. Human oral keratinocyte E-cadherin degradation by Candida albicans and Candida glabrata. J Oral Pathol Med. 2010;39:275-8 pubmed publisher
    ..E-cadherin (E-Cad) is a 120-kDa adhesive protein found in adherens junctions of the digestive tract epithelium. We tested the ability of two Candida strains to degrade human E-Cad in the Candida virulence factor perspective...
  48. Roetzer A, Klopf E, Gratz N, Marcet Houben M, Hiller E, Rupp S, et al. Regulation of Candida glabrata oxidative stress resistance is adapted to host environment. FEBS Lett. 2011;585:319-27 pubmed publisher
    The human fungal pathogen Candida glabrata is related to Saccharomyces cerevisiae but has developed high resistance against reactive oxygen species...
  49. Chaturvedi V, Ramani R, Andes D, Diekema D, Pfaller M, Ghannoum M, et al. Multilaboratory testing of two-drug combinations of antifungals against Candida albicans, Candida glabrata, and Candida parapsilosis. Antimicrob Agents Chemother. 2011;55:1543-8 pubmed publisher
    ..043, C. albicans 20464.007, Candida glabrata 20205.075, and C. parapsilosis 20580.070...
  50. Abbes S, Sellami H, Sellami A, Makni F, Mahfoudh N, Makni H, et al. Microsatellite analysis and susceptibility to FCZ of Candida glabrata invasive isolates in Sfax Hospital, Tunisia. Med Mycol. 2011;49:10-5 pubmed publisher
    ..albicans Candida species, particularly Candida glabrata. In many countries, the high frequency of Candida glabrata shows the highest resistance rates...
  51. Ruan S, Huang Y, Chu C, Yu C, Hsueh P. Candida glabrata fungaemia in a tertiary centre in Taiwan: antifungal susceptibility and outcomes. Int J Antimicrob Agents. 2009;34:236-9 pubmed publisher
    The proportion of non-albicans candidaemia has increased during recent decades, especially Candida glabrata. We evaluated the antifungal susceptibility, clinical features and outcome of C...
  52. Seneviratne C, Wang Y, Jin L, Abiko Y, Samaranayake L. Proteomics of drug resistance in Candida glabrata biofilms. Proteomics. 2010;10:1444-54 pubmed publisher
    b>Candida glabrata is a fungal pathogen that causes a variety of mucosal and systemic infections among compromised patient populations with higher mortality rates...
  53. Lowman D, West L, Bearden D, Wempe M, Power T, Ensley H, et al. New insights into the structure of (1?3,1?6)-?-D-glucan side chains in the Candida glabrata cell wall. PLoS ONE. 2011;6:e27614 pubmed publisher
    ..Herein, we report the first detailed structural characterization of the (1?6)-?-linked side chains of Candida glabrata using high-field NMR...
  54. Roetzer A, Gratz N, Kovarik P, Schüller C. Autophagy supports Candida glabrata survival during phagocytosis. Cell Microbiol. 2010;12:199-216 pubmed publisher
    The opportunistic human fungal pathogen Candida glabrata is confronted with phagocytic cells of the host defence system. Survival of internalized cells is thought to contribute to successful dissemination...
  55. Chapeland Leclerc F, Hennequin C, Papon N, Noel T, Girard A, Socie G, et al. Acquisition of flucytosine, azole, and caspofungin resistance in Candida glabrata bloodstream isolates serially obtained from a hematopoietic stem cell transplant recipient. Antimicrob Agents Chemother. 2010;54:1360-2 pubmed publisher
    We describe the acquisition of flucytosine, azole, and caspofungin resistance in sequential Candida glabrata bloodstream isolates collected from a bone marrow transplant patient with clinical failure. Point mutations in C...
  56. Ueno K, Matsumoto Y, Uno J, Sasamoto K, Sekimizu K, Kinjo Y, et al. Intestinal resident yeast Candida glabrata requires Cyb2p-mediated lactate assimilation to adapt in mouse intestine. PLoS ONE. 2011;6:e24759 pubmed publisher
    The intestinal resident Candida glabrata opportunistically infects humans. However few genetic factors for adaptation in the intestine are identified in this fungus. Here we describe the C...
  57. Howard S, Livermore J, Sharp A, Goodwin J, Gregson L, Alastruey Izquierdo A, et al. Pharmacodynamics of echinocandins against Candida glabrata: requirement for dosage escalation to achieve maximal antifungal activity in neutropenic hosts. Antimicrob Agents Chemother. 2011;55:4880-7 pubmed publisher
    b>Candida glabrata is a leading cause of disseminated candidiasis...
  58. Castanheira M, Woosley L, Diekema D, Messer S, Jones R, Pfaller M. Low prevalence of fks1 hot spot 1 mutations in a worldwide collection of Candida strains. Antimicrob Agents Chemother. 2010;54:2655-9 pubmed publisher
    ..Furthermore, results from this large, geographically diverse Candida spp. collection demonstrated that fks1 HS1 mutations remain uncommon among isolates with various echinocandin MIC levels...
  59. Tsai H, Sammons L, Zhang X, Suffis S, Su Q, Myers T, et al. Microarray and molecular analyses of the azole resistance mechanism in Candida glabrata oropharyngeal isolates. Antimicrob Agents Chemother. 2010;54:3308-17 pubmed publisher
    DNA microarrays were used to analyze Candida glabrata oropharyngeal isolates from seven hematopoietic stem cell transplant recipients whose isolates developed azole resistance while the recipients received fluconazole prophylaxis...
  60. Moran C, Grussemeyer C, Spalding J, Benjamin D, Reed S. Comparison of costs, length of stay, and mortality associated with Candida glabrata and Candida albicans bloodstream infections. Am J Infect Control. 2010;38:78-80 pubmed publisher
    We compared costs, length of stay, and mortality between adults with Candida albicans and Candida glabrata bloodstream infections...
  61. West L, Lowman D, Mora Montes H, Grubb S, Murdoch C, Thornhill M, et al. Differential virulence of Candida glabrata glycosylation mutants. J Biol Chem. 2013;288:22006-18 pubmed publisher
    The fungus Candida glabrata is an important and increasingly common pathogen of humans, particularly in immunocompromised hosts...
  62. Gherna M, Merz W. Identification of Candida albicans and Candida glabrata within 1.5 hours directly from positive blood culture bottles with a shortened peptide nucleic acid fluorescence in situ hybridization protocol. J Clin Microbiol. 2009;47:247-8 pubmed publisher
    Candida albicans and Candida glabrata can be identified in blood culture bottles within 2.5 h using peptide nucleic acid fluorescence in situ hybridization. A 1...
  63. Lott T, Frade J, Lyon G, Iqbal N, Lockhart S. Bloodstream and non-invasive isolates of Candida glabrata have similar population structures and fluconazole susceptibilities. Med Mycol. 2012;50:136-42 pubmed publisher
    We have compared multilocus sequence typing (MLST) and fluconazole susceptibility profiles of Candida glabrata bloodstream isolates obtained during active, population-based surveillance to those obtained from non-sterile sites of ..
  64. Yadav A, Desai P, Rai M, Kaur R, Ganesan K, Bachhawat A. Glutathione biosynthesis in the yeast pathogens Candida glabrata and Candida albicans: essential in C. glabrata, and essential for virulence in C. albicans. Microbiology. 2011;157:484-95 pubmed publisher
    ..of glutathione biosynthesis in two major human opportunistic fungal pathogens, Candida albicans and Candida glabrata. As the genome sequence of C...
  65. Riera M, Mogensen E, d Enfert C, Janbon G. New regulators of biofilm development in Candida glabrata. Res Microbiol. 2012;163:297-307 pubmed publisher
    ..to identify and characterize genes involved in the formation of biofilms by the opportunistic fungal pathogen Candida glabrata. We identified the Cst6p transcription factor as a negative regulator of the EPA6 gene that encodes an ..
  66. Saijo T, Miyazaki T, Izumikawa K, Mihara T, Takazono T, Kosai K, et al. Skn7p is involved in oxidative stress response and virulence of Candida glabrata. Mycopathologia. 2010;169:81-90 pubmed publisher
    b>Candida glabrata is an opportunistic fungal pathogen that causes both superficial and deep-seated mycosis in humans...
  67. Berila N, Subik J. Molecular analysis of Candida glabrata clinical isolates. Mycopathologia. 2010;170:99-105 pubmed publisher
    b>Candida glabrata is an important human pathogen, and an understanding of the genetic relatedness of its clinical isolates is essential for the prevention and control of fungal infections...
  68. Pfaller M, Diekema D, Gibbs D, Newell V, Barton R, Bijie H, et al. Geographic variation in the frequency of isolation and fluconazole and voriconazole susceptibilities of Candida glabrata: an assessment from the ARTEMIS DISK Global Antifungal Surveillance Program. Diagn Microbiol Infect Dis. 2010;67:162-71 pubmed publisher
    Geographic differences in frequency and azole resistance among Candida glabrata may impact empiric antifungal therapy choice. We examined geographic variation in isolation and azole susceptibility of C. glabrata...
  69. Gomes P, da Silva W, Pousa C, Narvaes E, Del Bel Cury A. Bioactivity and cellular structure of Candida albicans and Candida glabrata biofilms grown in the presence of fluconazole. Arch Oral Biol. 2011;56:1274-81 pubmed publisher
    The aim of this study was to evaluate whether fluconazole (FLZ) could affect the bioactivity and cellular structure of Candida albicans or Candida glabrata biofilms grown in the presence of FLZ.
  70. Sutherland A, Ellis D. Treatment of a critically ill child with disseminated Candida glabrata with a recombinant human antibody specific for fungal heat shock protein 90 and liposomal amphotericin B, caspofungin, and voriconazole. Pediatr Crit Care Med. 2008;9:e23-5 pubmed publisher
    ..To report a case of fungal sepsis treated prospectively with liposomal amphotericin, caspofungin, and a novel monoclonal antibody specific for candidal heat shock protein 90 (Mycograb, Neutec Pharma, Manchester, UK)...
  71. Durán Valle M, Gago S, Gomez Lopez A, Cuenca Estrella M, Jiménez Díez Canseco L, Gómez Garcés J, et al. Recurrent episodes of candidemia due to Candida glabrata with a mutation in hot spot 1 of the FKS2 gene developed after prolonged therapy with caspofungin. Antimicrob Agents Chemother. 2012;56:3417-9 pubmed publisher
    We report two episodes of recurrent candidemia caused by echinocandin-resistant Candida glabrata in a 69-year-old patient who underwent repeated abdominal surgery...
  72. Klevay M, Horn D, Neofytos D, Pfaller M, Diekema D. Initial treatment and outcome of Candida glabrata versus Candida albicans bloodstream infection. Diagn Microbiol Infect Dis. 2009;64:152-7 pubmed publisher
    b>Candida glabrata is a common cause of bloodstream infection (BSI) and exhibits decreased susceptibility to fluconazole. We sought to determine whether patients with C...
  73. Inui S, Nakamura T, Tanabe K, Ohno H, Koike C, Okuda K, et al. [A case of micafungin-hyposensitive Candida glabrata due to FKS2 gene mutation]. Kansenshogaku Zasshi. 2011;85:49-53 pubmed
    b>Candida glabrata was continuously isolated in cultured urine samples from a subject with thrombotic thrombocytopenic purpura...
  74. Ferrari S, Sanguinetti M, De Bernardis F, Torelli R, Posteraro B, Vandeputte P, et al. Loss of mitochondrial functions associated with azole resistance in Candida glabrata results in enhanced virulence in mice. Antimicrob Agents Chemother. 2011;55:1852-60 pubmed publisher
    Mitochondrial dysfunction is one of the possible mechanisms by which azole resistance can occur in Candida glabrata. Cells with mitochondrial DNA deficiency (so-called "petite mutants") upregulate ATP binding cassette (ABC) ..
  75. Srikantha T, Daniels K, Wu W, Lockhart S, Yi S, Sahni N, et al. Dark brown is the more virulent of the switch phenotypes of Candida glabrata. Microbiology. 2008;154:3309-18 pubmed publisher
    b>Candida glabrata undergoes reversible, high-frequency core switching between phenotypes that include dark brown (DB), light brown (LB) and white (Wh). These phenotypes in turn can switch to the irregular wrinkle (IWr) phenotype...
  76. Kuhn D, Vyas V. The Candida glabrata adhesin Epa1p causes adhesion, phagocytosis, and cytokine secretion by innate immune cells. FEMS Yeast Res. 2012;12:398-414 pubmed publisher
    While Candida albicans is the most significant fungal pathogen for humans, Candida glabrata accounts for an increasing number of infections. Little is known about how C...
  77. Lelandais G, Tanty V, Geneix C, Etchebest C, Jacq C, Devaux F. Genome adaptation to chemical stress: clues from comparative transcriptomics in Saccharomyces cerevisiae and Candida glabrata. Genome Biol. 2008;9:R164 pubmed publisher
    ..and promoter analyses in a study of the evolution of transcriptional networks responding to an antifungal agent in two yeast species: the free-living model organism Saccharomyces cerevisiae and the human pathogen Candida glabrata.
  78. Olchawa A, Krawczyk B, Brillowska Dabrowska A. New PCR test for detection of Candida glabrata based on the molecular target chosen by the RAPD technique. Pol J Microbiol. 2013;62:81-4 pubmed
    ..A sequence encoding Candida glabrata CBS138 hypothetical protein was selected...
  79. Takahashi S, Kudoh A, Okawa Y, Shibata N. Significant differences in the cell-wall mannans from three Candida glabrata strains correlate with antifungal drug sensitivity. FEBS J. 2012;279:1844-56 pubmed publisher
    ..Interestingly, the NBRC 103857 strain, which involved a large amount of the ?-1,2-linked mannose residues, exhibited significant sensitivity to these antifungal drugs...
  80. Nagi M, Tanabe K, Ueno K, Nakayama H, Aoyama T, Chibana H, et al. The Candida glabrata sterol scavenging mechanism, mediated by the ATP-binding cassette transporter Aus1p, is regulated by iron limitation. Mol Microbiol. 2013;88:371-81 pubmed publisher
    During disseminated infection by the opportunistic pathogen Candida glabrata, uptake of sterols such as serum cholesterol may play a significant role during pathogenesis...
  81. Fukuda Y, Tsai H, Myers T, Bennett J. Transcriptional profiling of Candida glabrata during phagocytosis by neutrophils and in the infected mouse spleen. Infect Immun. 2013;81:1325-33 pubmed publisher
    Expression microarray analysis of Candida glabrata following phagocytosis by human neutrophils was performed, and results were compared with those from C. glabrata incubated under conditions of carbohydrate or nitrogen deprivation...
  82. Katiyar S, Alastruey Izquierdo A, Healey K, Johnson M, Perlin D, Edlind T. Fks1 and Fks2 are functionally redundant but differentially regulated in Candida glabrata: implications for echinocandin resistance. Antimicrob Agents Chemother. 2012;56:6304-9 pubmed publisher
    ..were recently elevated to first-line agents for treating infections due to the azole-refractory yeast Candida glabrata. In Candida albicans, echinocandin resistance is strictly associated with mutations in Fks1, a large integral ..
  83. Shen Y, Lu H, Zhang Y. [Molecular mechanisms of fluconazole resistance in clinical isolates of Candida glabrata]. Zhonghua Nei Ke Za Zhi. 2010;49:245-9 pubmed
    ..of ERG11, CDR1 and CDR2 genes could be associated with resistance phenotype in clinical isolates of Candida glabrata (C. glabrata). ..
  84. Zhou J, Liu L, Chen J. Mitochondrial DNA heteroplasmy in Candida glabrata after mitochondrial transformation. Eukaryot Cell. 2010;9:806-14 pubmed publisher
    ..In this study, the ATP6 gene on mtDNA of the haploid yeast Candida glabrata (Torulopsis glabrata) was deleted by biolistic transformation of DNA fragments with a recoded ARG8(m) ..
  85. Rosas Hernández L, Juárez Reyes A, Arroyo Helguera O, De Las Peñas A, Pan S, Cormack B, et al. yKu70/yKu80 and Rif1 regulate silencing differentially at telomeres in Candida glabrata. Eukaryot Cell. 2008;7:2168-78 pubmed publisher
    b>Candida glabrata, a common opportunistic fungal pathogen, adheres efficiently to mammalian epithelial cells in culture. This interaction in vitro depends mainly on the adhesin Epa1, one of a large family of cell wall proteins...