Summary: A mitosporic fungal genus including both saprophytes and plant parasites.

Top Publications

  1. Hasan S, Gambale W, Zollner R, Santana M. Fungi allergens produced by solid-state fermentation process: optimization and allergen characterization. Appl Biochem Biotechnol. 2003;105 -108:403-12 pubmed
    Allergenic extracts were produced from Drechslera (Helminthosporium) monoceras biomass cultured by solid-state fermentation using wheat bran as the substrate...
  2. Diene O, Takahashi T, Yonekura A, Nitta Y, Narisawa K. A new fungal endophyte, Helminthosporium velutinum, promoting growth of a bioalcohol plant, sweet sorghum. Microbes Environ. 2010;25:216-9 pubmed
    A new fungal isolate that grows endophytically in sweet sorghum was identified as Helminthosporium velutinum Link ex Ficinus & Schubert...
  3. Soldevila A, Ghabrial S. A novel alcohol oxidase/RNA-binding protein with affinity for mycovirus double-stranded RNA from the filamentous fungus Helminthosporium (Cochliobolus) victoriae: molecular and functional characterization. J Biol Chem. 2001;276:4652-61 pubmed
    We have cloned and sequenced a novel alcohol oxidase (Hv-p68) from the filamentous fungus Helminthosporium (Cochliobolus) victoriae that copurifies with mycoviral double-stranded RNAs...
  4. Huang S, Soldevila A, Webb B, Ghabrial S. Expression, assembly, and proteolytic processing of Helminthosporium victoriae 190S totivirus capsid protein in insect cells. Virology. 1997;234:130-7 pubmed
    The dsRNA genome (5.2 kbp) of Helminthosporium victoriae 190S totivirus (Hv190SV) consists of two large overlapping open reading frames (ORFs)...
  5. de Sá P, Havens W, Ghabrial S. Characterization of a novel broad-spectrum antifungal protein from virus-infected Helminthosporium (Cochliobolus) victoriae. Phytopathology. 2010;100:880-9 pubmed publisher
    ..victoriocin, was purified from culture filtrates of a virus-infected isolate of the plant-pathogenic fungus Helminthosporium victoriae (teleomorph: Cochliobolus victoriae) by a multistep procedure involving ultrafiltration and reverse-..
  6. de Sá P, Li H, Havens W, Farman M, Ghabrial S. Overexpression of the victoriocin gene in Helminthosporium (Cochliobolus) victoriae enhances the antifungal activity of culture filtrates. Phytopathology. 2010;100:890-6 pubmed publisher
    ..protein, victoriocin, from culture filtrates of a virus-infected isolate of the plant-pathogenic fungus Helminthosporium (teleomorph: Cochliobolus) victoriae...
  7. Huang S, Ghabrial S. Organization and expression of the double-stranded RNA genome of Helminthosporium victoriae 190S virus, a totivirus infecting a plant pathogenic filamentous fungus. Proc Natl Acad Sci U S A. 1996;93:12541-6 pubmed
    The complete nucleotide sequence, 5178 bp, of the totivirus Helminthosporium vicotoriae 190S virus (Hv190SV) double-stranded RNA, was determined...
  8. Ahn J, Walton J. A fatty acid synthase gene in Cochliobolus carbonum required for production of HC-toxin, cyclo(D-prolyl-L-alanyl-D-alanyl-L-2-amino-9, 10-epoxi-8-oxodecanoyl). Mol Plant Microbe Interact. 1997;10:207-14 pubmed
    ..The most plausible function of TOXC is to contribute to the synthesis of the decanoic acid backbone of Aeo. ..
  9. Ghabrial S, Havens W. The Helminthosporium victoriae 190S mycovirus has two forms distinguishable by capsid protein composition and phosphorylation state. Virology. 1992;188:657-65 pubmed
    Purified preparations of the Helminthosporium victoriae 190S (Hv190S) virus contain two sedimenting components that differ in capsid structure...

More Information


  1. Black P, Udy A, Brodie S. Sensitivity to fungal allergens is a risk factor for life-threatening asthma. Allergy. 2000;55:501-4 pubmed
    ..Skin prick tests for fungal spores (Alternaria tenuis, Cladosporium cladosporoides, Helminthosporium maydis, and Epicoccum nigrum), cat dander, house-dust mite (Dermatophagoides pteronyssinus), and a seven-..
  2. el Shaaer H, Abdel Aziz S, Allimony H, Ali U, Abdel Rahman R. Synthesis and antimicrobial activities of some new 2-substituted benzoxazole/benzothiazole derivatives. Pharmazie. 1997;52:585-9 pubmed
    ..The structure of the products was deduced from elemental analyses as well as spectral data (IR, 1H NMR and MS). Significant antimicrobial activities were obtained for all new compounds especially against Fusarium oxysporum. ..
  3. Pitkin J, Panaccione D, Walton J. A putative cyclic peptide efflux pump encoded by the TOXA gene of the plant-pathogenic fungus Cochliobolus carbonum. Microbiology. 1996;142 ( Pt 6):1557-65 pubmed
  4. Ghabrial S, Dunn S, Li H, Xie J, Baker T. Viruses of Helminthosporium (Cochlioblus) victoriae. Adv Virus Res. 2013;86:289-325 pubmed publisher
    The enigma of the transmissible disease of Helminthosporium victoriae has almost been resolved...
  5. Liu S, Jiang H, Guan T, Qi S, Gu Y, Zhao K, et al. [Screening of antifungi endophytic actinomyces strains from salvia przewalskii in Tibean Plateau]. Zhongguo Zhong Yao Za Zhi. 2013;38:3256-60 pubmed
    ..Fusarium moniliforme, Helminthosporium turcicum and Bipolaris maydis were selected as indicator fungi to test the antimicrobial activities of these ..
  6. Alves dos Reis T, Zorzete P, Pozzi C, Nascimento da Silva V, Ortega E, Correa B. Mycoflora and fumonisin contamination in Brazilian sorghum from sowing to harvest. J Sci Food Agric. 2010;90:1445-51 pubmed publisher
    ..61.8%) and Helminthosporium spp. (33.4%). Fusarium verticillioides was isolated from 15...
  7. Deubzer H, Ehemann V, Westermann F, Heinrich R, Mechtersheimer G, Kulozik A, et al. Histone deacetylase inhibitor Helminthosporium carbonum (HC)-toxin suppresses the malignant phenotype of neuroblastoma cells. Int J Cancer. 2008;122:1891-900 pubmed
    ..This study shows that the histone deacetylase inhibitor Helminthosporium carbonum (HC)-toxin suppresses the malignant phenotype of both established NB cell lines and primary NB cells ..
  8. Holland H, Gu J, Orallo F, Camiña M, Fabeiro P, Willetts A. Enantioselective synthesis and pharmacological evaluation of a new type of verapamil analog with hypotensive and calcium antagonist activities. Pharm Res. 1999;16:281-7 pubmed
    ..The results suggest that, like that of verapamil, the cardiovascular activity exhibited by the new compounds seems to be due, at least in part, to a blockage of transmembrane calcium channels present in vascular smooth muscle cells. ..
  9. Martinez C, Rioux D, Tweddell R. Ultrastructure of the infection process of potato tuber by Helminthosporium solani, causal agent of potato silver scurf. Mycol Res. 2004;108:828-36 pubmed
    Silver scurf is an important postharvest disease affecting potato tubers worldwide, caused by Helminthosporium solani. In the present study, key steps of infection of potato tubers (cv. 'Dark Red Norland') by H...
  10. Degefu Y, Hanif M. Agrobacterium- tumefaciens-mediated transformation of Helminthosporium turcicum, the maize leaf-blight fungus. Arch Microbiol. 2003;180:279-84 pubmed
    ..Conidia of the maize pathogen Helminthosporium turcicum were transformed to hygromycin B resistance by a Agrobacterium- tumefaciens-mediated transformation ..
  11. Zhao Y, Lu X, Liu C, Guan H, Zhang M, Li Z, et al. Identification and fine mapping of rhm1 locus for resistance to Southern corn leaf blight in maize. J Integr Plant Biol. 2012;54:321-9 pubmed publisher
    ..Our results strongly suggest LHT1 as the candidate gene for rhm1 against SCLB. The tightly linked molecular markers developed in this study can be directly used for molecular breeding of resistance to Southern corn leaf blight in maize...
  12. Shaik A, Ahil S, Govardhanam R, Senthi M, Khan R, Sojitra R, et al. Antifungal Effect and Protective Role of Ursolic Acid and Three Phenolic Derivatives in the Management of Sorghum Grain Mold Under Field Conditions. Chem Biodivers. 2016;13:1158-1164 pubmed publisher
    ..pallidoroseum, and Helminthosporium sp. Significant growth inhibition (P < 0.001) was observed against all fungi except A...
  13. Jegathambigai V, Karunaratne M, Svinningen A, Mikunthan G. Potential of Trichoderma species on Helminthosporium causing leaf spot on cane palm, Chrysalidocarpus lutescens. Commun Agric Appl Biol Sci. 2008;73:207-16 pubmed
    ..The export quality of C. lutescens was declined due to the repeated occurrence of a leaf spot caused by Helminthosporium. Widespread occurrence of the leaf spot affected the cane palm production and succumb it to a huge setback in ..
  14. Weber R. Helminthosporium. Ann Allergy Asthma Immunol. 2005;95:A6 pubmed
  15. Cheng M, Tzen J, Shyu D, Chou W. Functional characterization of the N-terminal and C-terminal domains of a sesame group II phytocystatin. Bot Stud. 2014;55:18 pubmed publisher
    ..possessed comparable ability to inhibit spore germination of Trichoderma reesei, Aspergillus sydowii, and Helminthosporium sesamum...
  16. Jones J. Plant pathology. Resistance crumbles?. Curr Biol. 1994;4:67-9 pubmed
    ..A plant disease resistance gene, of the kind involved in "gene-for-gene" interactions with pathogens, has been cloned and found to encode a putative serine/threonine kinase. ..
  17. Huang W, Wilcox R, Davis P. Comparative molecular field analysis (CoMFA) for sulfoxidation reactions in Mortierella isabellina ATCC 42613 and Helminthosporium sp. NRRL 4671. J Mol Model. 2002;8:8-23 pubmed
    ..species of microorganisms that have been used as models for mammalian metabolism, Mortierella isabellina and Helminthosporium sp...
  18. Menezes E, Gambale W, Macedo M, Abdalla D, Paula C, Croce J. Biochemical, antigenic and allergenic characterization of crude extracts of Drechslera (Helminthosporium) monoceras. Mycopathologia. 1995;131:75-81 pubmed
    In a previous study with airborne mould extracts we verified that Drechslera (Helminthosporium) monoceras presented stronger reactions than those presented by 42 other moulds isolated in São Paulo city...
  19. Corey J, Kaiseruddin S, Gungor A. Prevalence of mold-specific immunoglobulins in a Midwestern allergy practice. Otolaryngol Head Neck Surg. 1997;117:516-20 pubmed
    ..test for allergen-specific IgE (ImmunoCAP) comprised of 10 allergens, including Candida, Aspergillus, Helminthosporium, and Alternaria, was used...
  20. Khan N, Bano A. Modulation of phytoremediation and plant growth by the treatment with PGPR, Ag nanoparticle and untreated municipal wastewater. Int J Phytoremediation. 2016;18:1258-69 pubmed publisher
    ..aeruginosa, Bacillus subtilis, Klebsiella pneumoniae and Escherichia coli and antifungal activities against Helminthosporium sativum and Fusarium solani...
  21. Osterhage C, König G, Höller U, Wright A. Rare sesquiterpenes from the algicolous fungus Drechslera dematioidea. J Nat Prod. 2002;65:306-13 pubmed
    ..All structures were elucidated using spectroscopic methods, mainly 1D and 2D NMR and MS. ..
  22. Xie J, Havens W, Lin Y, Suzuki N, Ghabrial S. The victorivirus Helminthosporium victoriae virus 190S is the primary cause of disease/hypovirulence in its natural host and a heterologous host. Virus Res. 2016;213:238-245 pubmed publisher
    A transmissible disease of the plant pathogenic fungus Helminthosporium victoriae, the causal agent of Victoria blight of oats, was reported more than 50 years ago. Diseased, but not normal, isolates, of H...
  23. Deubzer H, Ehemann V, Kulozik A, Westermann F, Savelyeva L, Kopp Schneider A, et al. Anti-neuroblastoma activity of Helminthosporium carbonum (HC)-toxin is superior to that of other differentiating compounds in vitro. Cancer Lett. 2008;264:21-8 pubmed publisher
    ..We have previously shown that the histone deacetylase inhibitor (HDACI) Helminthosporium carbonum (HC)-toxin induces differentiation of neuroblastoma (NB) cells...
  24. Soldevila A, Huang S, Ghabrial1 S. Assembly of the Hv190S totivirus capsid is independent of posttranslational modification of the capsid protein. Virology. 1998;251:327-33 pubmed
    The genome of Helminthosporium victoriae 190S totivirus (Hv190SV) consists of two large overlapping open reading frames (ORFs), encoding a capsid protein (CP) and an RNA-dependent RNA polymerase...
  25. Gómez Ariza J, Campo S, Rufat M, Estopà M, Messeguer J, San Segundo B, et al. Sucrose-mediated priming of plant defense responses and broad-spectrum disease resistance by overexpression of the maize pathogenesis-related PRms protein in rice plants. Mol Plant Microbe Interact. 2007;20:832-42 pubmed
    ..protection against pathogens, including fungal (Magnaporthe oryzae, Fusarium verticillioides, and Helminthosporium oryzae) and bacterial (Erwinia chrysanthemi) pathogens...
  26. González Díaz S, Arias Cruz A, Rivero Arias D, Partida Ortega A, Elizondo Villarreal B, Ibarra Chávez J, et al. [Cross-reactivity in allergic fungal sinusitis. Case report]. Rev Alerg Mex. 2016;63:316-9 pubmed
    ..Two weeks after surgery, percutaneous tests showed sensitization to Alternaria, Helminthosporium sativum, and Deramatophagoides farianae with negativity to Aspergillus fumigatus...
  27. Miyazaki S, Jiang K, Kobayashi M, Asami T, Nakajima M. Helminthosporic acid functions as an agonist for gibberellin receptor. Biosci Biotechnol Biochem. 2017;81:2152-2159 pubmed publisher
    Helminthosporol was isolated from a fungus, Helminthosporium sativum, as a natural plant growth regulator in 1963. It showed gibberellin-like bioactivity that stimulated the growth of the second leaf sheath of rice...
  28. Trost B, Shen H, Surivet J. Biomimetic enantioselective total synthesis of (-)-siccanin via the Pd-catalyzed asymmetric allylic alkylation (AAA) and sequential radical cyclizations. J Am Chem Soc. 2004;126:12565-79 pubmed
    ..These studies may shed light on the biosynthesis of this novel family of compounds. ..
  29. Ág N, Flipphi M, Karaffa L, Scazzocchio C, Fekete E. Alternatively spliced, spliceosomal twin introns in Helminthosporium solani. Fungal Genet Biol. 2015;85:7-13 pubmed publisher
    ..Here we describe and experimentally verify two novel stwintrons of the potato pathogen Helminthosporium solani...
  30. Cai H, Gao Z, Yuyama N, Ogawa N. Identification of AFLP markers closely linked to the rhm gene for resistance to Southern Corn Leaf Blight in maize by using bulked segregant analysis. Mol Genet Genomics. 2003;269:299-303 pubmed
    ..Combined with the previously identified agrP144, this new marker may be useful for map-based cloning of the rhm gene and marker-assisted selection for rhm. ..
  31. Srivastava S, Chowdhury A, Maurya S. Antimicrobial Efficacy of Methylated Lac Dye, an Anthraquinone Derivative. Indian J Microbiol. 2017;57:470-476 pubmed publisher
    ..i>Alternaria solani, Curvularia lunata, Erysiphe pisi, Helminthosporium oryzae and Verticillium sp. Among the tested fungi, Verticillum sp...
  32. Tantong S, Pringsulaka O, Weerawanich K, Meeprasert A, Rungrotmongkol T, Sarnthima R, et al. Two novel antimicrobial defensins from rice identified by gene coexpression network analyses. Peptides. 2016;84:7-16 pubmed publisher
    ..6 to 63μg/mL. However, these OsDEFs are weakly active against the phytopathogenic fungi Helminthosporium oryzae and Fusarium oxysporum f.sp. cubense...
  33. Anaya A, Mata R, Sims J, González Coloma A, Cruz Ortega R, Guadaño A, et al. Allelochemical potential of Callicarpa acuminata. J Chem Ecol. 2003;29:2761-76 pubmed
    ..Some of these treatments caused a moderate inhibition of the radial growth of two phytopathogenic fungi, Helminthosporium longirostratum and Alternaria solani (18-31%)...
  34. Aktuganov G, Melent ev A, Kuz mina L, Galimzianova N, Shirokov A. [Chitinolytic activity of Bacillus Cohn.--phytopathogenic fungus antagonist]. Mikrobiologiia. 2003;72:356-60 pubmed
    ..45), although the enzymatic preparations of most of these strains inhibited the growth of the phytopathogenic fungus Helminthosporium sativum.
  35. Corcuff R, Mercier J, Tweddell R, Arul J. Effect of water activity on the production of volatile organic compounds by Muscodor albus and their effect on three pathogens in stored potato. Fungal Biol. 2011;115:220-7 pubmed publisher
    ..culture, and their inhibitory effects on the growth of three pathogens of potato tuber (Fusarium sambucinum, Helminthosporium solani, and Pectobacterium atrosepticum) and the development of diseases caused by the three pathogens (dry ..
  36. Soldevila A, Havens W, Ghabrial S. A cellular protein with an RNA-binding activity co-purifies with viral dsRNA from mycovirus-infected Helminthosporium victoriae. Virology. 2000;272:183-90 pubmed
    A cellular protein that co-purifies with mycoviral dsRNA was isolated from the plant pathogenic fungus Helminthosporium victoriae (telomorph: Cochliobolus victoriae) infected with two viruses, the totivirus Helminthosporium victoriae 190S ..
  37. Ackermann B, Holland J, Watson J. Comparison of thermally-assisted fast atom bombardment (TA-FAB) with conventional FAB and EI mass spectrometry for the analysis of the Helminthosporium carbonum mycotoxins. Biomed Environ Mass Spectrom. 1987;14:501-11 pubmed
    ..comparisons are made between TA-FAB, conventional FAB, and electron impact ionization for the analysis of the Helminthosporium carbonum mycotoxins at the 1.5 micrograms level...
  38. Xu H, Wang Q, Yang W. Antifungal activities of some indole derivatives. Z Naturforsch C. 2010;65:437-9 pubmed
    Nine indole derivatives were evaluated in vitro against Fusarium graminearum, Alternaria alternata, Helminthosporium sorokinianum, Pyricularia oryzae, Fusarium oxysporum f. sp. vasinfectum, Fusarium oxysporum f. sp...
  39. Holland H, Brown F, Larsen B. Biotransformation of organic sulfides--IV. Formation of chiral benzyl alkyl and phenyl alkyl sulfoxides by Helminthosporium species NRRL 4671. Bioorg Med Chem. 1994;2:647-52 pubmed
    The fungus Helminthosporium species NRRL 4671 has been used for the biotransformation of a series of phenyl alkyl sulfides with alkyl groups ranging from methyl to n-hexyl, and benzyl alkyl sulfides with alkyl groups from methyl to n-..
  40. Shirokov A, Loginov O, Melent ev A, Aktuganov G. [Protein and peptide factors from Bacillus sp.739 inhibit the growth of phytopathogenic fungi]. Prikl Biokhim Mikrobiol. 2002;38:161-5 pubmed
    Thermolabile peptides inhibiting the growth of Helminthosporium sativum, a facultative phytopathogen, have been isolated from the low-molecular-weight fraction of extracellular metabolites of the strain Bacillus sp. 739...
  41. Manning S, Mabry R, Schaefer S, Close L. Evidence of IgE-mediated hypersensitivity in allergic fungal sinusitis. Laryngoscope. 1993;103:717-21 pubmed
    ..Thus, modified RAST testing can aid in the routine clinical diagnosis of AFS, and it provides further serologic evidence for a type I hypersensitivity in the pathogenesis of AFS. ..
  42. Mabry R, Marple B, Mabry C. Outcomes after discontinuing immunotherapy for allergic fungal sinusitis. Otolaryngol Head Neck Surg. 2000;122:104-6 pubmed
    ..In this initial, admittedly small series, no recurrence has been noted in follow-up of 7 to 17 months. ..
  43. Errampalli D, Saunders J, Cullen D. A PCR-based method for detection of potato pathogen, Helminthosporium solani, in silver scurf infected tuber tissue and soils. J Microbiol Methods. 2001;44:59-68 pubmed
    Silver scurf caused by Helminthosporium solani causes significant economic losses in table stock, seed and processing potatoes. Specific polymerase chain reaction (PCR) primers, Hs1F1/Hs2R1, from H...
  44. Johal G, Briggs S. Reductase activity encoded by the HM1 disease resistance gene in maize. Science. 1992;258:985-7 pubmed
    ..This indicates that HM1 encodes HCTR. ..
  45. Suzuki Mizushima Y, Gohda E, Okamura T, Kanasaki K, Yamamoto I. Enhancement of NGF- and cholera toxin-induced neurite outgrowth by butyrate in PC12 cells. Brain Res. 2002;951:209-17 pubmed
    ..Furthermore, Helminthosporium carbonum toxin (HC toxin), a structurally dissimilar inhibitor of histone deacetylase, mimicked the effect of ..
  46. McKay G, Cooke L. A PCR-based method to characterise and identify benzimidazole resistance in Helminthosporium solani. FEMS Microbiol Lett. 1997;152:371-8 pubmed
    Control of Helminthosporium solani, the cause of silver scurf in potato tubers, has been impaired by selection of benzimidazole-resistant strains as a result of repeated use of the fungicide thiabendazole...
  47. Rothe G, Welschbillig N, Reiss E. Molecular size and net charge of pathogenesis-related enzymes from barley (Hordeum vulgare L., v. Karat) infected with Drechslera teres f. teres (Sacch.) Shoem. Electrophoresis. 1998;19:745-51 pubmed
    ..05) than adaptive beta-1,3-glucanase 1 (molecular mass 26 +/- 4 kDa; f/fo = 1.07). The valence of adaptive beta-1,3-glucanase 1 (Z = 9.58 +/- 4.17) was approximately threefold that of beta-1,3-glucanase 2 (Z = 2.80 +/- 0.93). ..
  48. Roll D, Manning J, Carter G. Hongoquercins A and B, new sesquiterpenoid antibiotics: isolation, structure elucidation, and antibacterial activity. J Antibiot (Tokyo). 1998;51:635-9 pubmed
    ..They are related to a class of compounds commonly found in brown algae and dictyoceratid sponges. Hongoquercin A exhibited moderate activity against gram-positive bacteria. ..
  49. Siedow J, Rhoads D, Ward G, Levings C. The relationship between the mitochondrial gene T-urf13 and fungal pathotoxin sensitivity in maize. Biochim Biophys Acta. 1995;1271:235-40 pubmed
    ..Experimental evidence indicates that URF13 acts as a ligand-gated, pore-forming T-toxin receptor. ..
  50. Degefu Y, Lohtander K, Paulin L. Expression patterns and phylogenetic analysis of two xylanase genes (htxyl1 and htxyl2) from Helminthosporium turcicum, the cause of northern leaf blight of maize. Biochimie. 2004;86:83-90 pubmed
    A xylanase gene (htxyl2) was cloned from Helminthosporium turcicum, the cause of northern leaf blight of maize by screening the genomic library from the fungus using a approximately 500 bp PCR fragment of the gene as a probe...
  51. Tardi Ovadia R, Linker R, Tsror Lahkim L. Direct Estimation of Local pH Change at Infection Sites of Fungi in Potato Tubers. Phytopathology. 2017;107:132-137 pubmed
    ..The objective of the present study was to examine the ability of two fungi, Colletotrichum coccodes and Helminthosporium solani, to modify the pH of potato tubers during artificial inoculation in situ...
  52. Taye T, Gossmann M, Einhorn G, Buttner C, Metz R, Abate D. The potential of pathogens as biological control of parthenium weed (Parthenium hysterophorus L.) in Ethiopia. Meded Rijksuniv Gent Fak Landbouwkd Toegep Biol Wet. 2002;67:409-20 pubmed
    ..Among them were putative pathogenic fungal species of the genus Helminthosporium, Phoma, Curvularia, Chaetomium, Alternaria, and Fusarium...