aspergillus flavus

Summary

Summary: A species of imperfect fungi which grows on peanuts and other plants and produces the carcinogenic substance aflatoxin. It is also used in the production of the antibiotic flavicin.

Top Publications

  1. Abbas H, Zablotowicz R, Horn B, Phillips N, Johnson B, Jin X, et al. Comparison of major biocontrol strains of non-aflatoxigenic Aspergillus flavus for the reduction of aflatoxins and cyclopiazonic acid in maize. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2011;28:198-208 pubmed publisher
    Biological control of toxigenic Aspergillus flavus in maize through competitive displacement by non-aflatoxigenic strains was evaluated in a series of field studies...
  2. Duan X, Jiang R, Wen Y, Bin J. Some 2S albumin from peanut seeds exhibits inhibitory activity against Aspergillus flavus. Plant Physiol Biochem. 2013;66:84-90 pubmed publisher
    ..Untreated 2S albumin had little inhibitory activity against trypsin, spore germination, or hyphal growth of Aspergillus flavus. However, following treatment of 2S albumin with SDS, increased inhibitory activity was demonstrated...
  3. Baker R, Brown R, Chen Z, Cleveland T, Fakhoury A. A maize lectin-like protein with antifungal activity against Aspergillus flavus. J Food Prot. 2009;72:120-7 pubmed
    The filamentous fungus Aspergillus flavus causes an ear rot on maize and produces a mycotoxin (aflatoxin) in colonized maize kernels. Aflatoxins are carcinogenic to humans and animals upon ingestion...
  4. Brun S, Fekkar A, Busse A, Seilhean D, Lecso M, Adler D, et al. Aspergillus flavus brain abscesses associated with hepatic amebiasis in a non-neutropenic man in Senegal. Am J Trop Med Hyg. 2009;81:583-6 pubmed publisher
    ..Surprisingly, the post-mortem examinations of brain abscesses showed Aspergillus flavus. The route of infection by A. flavus in this particular context is discussed.
  5. Andleeb S, Atiq N, Robson G, Ahmed S. An investigation of anthraquinone dye biodegradation by immobilized Aspergillus flavus in fluidized bed bioreactor. Environ Sci Pollut Res Int. 2012;19:1728-37 pubmed publisher
    Biodegradation and biodecolorization of Drimarene blue K(2)RL (anthraquinone) dye by a fungal isolate Aspergillus flavus SA2 was studied in lab-scale immobilized fluidized bed bioreactor (FBR) system. Fungus was immobilized on 0...
  6. Mousa W, Ghazali F, Jinap S, Ghazali H, Radu S. Modelling the effect of water activity and temperature on growth rate and aflatoxin production by two isolates of Aspergillus flavus on paddy. J Appl Microbiol. 2011;111:1262-74 pubmed publisher
    This study was conducted to characterize the growth of and aflatoxin production by Aspergillus flavus on paddy and to develop kinetic models describing the growth rate as a function of water activity (a(w)) and temperature...
  7. Leema G, Kaliamurthy J, Geraldine P, Thomas P. Keratitis due to Aspergillus flavus: clinical profile, molecular identification of fungal strains and detection of aflatoxin production. Mol Vis. 2010;16:843-54 pubmed
    To document the clinical profile of patients with keratitis due to Aspergillus flavus and to elaborate on differences in the aflatoxin-producing potential of keratitis strains versus environmental strains of A. flavus...
  8. Chang P, Scharfenstein L, Li P, Ehrlich K. Aspergillus flavus VelB acts distinctly from VeA in conidiation and may coordinate with FluG to modulate sclerotial production. Fungal Genet Biol. 2013;58-59:71-9 pubmed publisher
    ..VeA and VelB of A. nidulans and Aspergillus fumigatus also are repressors of conidiation, but VeA of Aspergillus flavus in studied strains acts positively on conidiation...
  9. Nogueira J, Gonçalez E, Galleti S, Facanali R, Marques M, Felicio J. Ageratum conyzoides essential oil as aflatoxin suppressor of Aspergillus flavus. Int J Food Microbiol. 2010;137:55-60 pubmed publisher
    ..effects of essential oil of Ageratum conyzoides, on the mycelial growth and aflatoxin B(1) production by Aspergillus flavus were studied...
  10. Scully L, Bidochka M. An alternative insect pathogenic strategy in an Aspergillus flavus auxotroph. Mycol Res. 2009;113:230-9 pubmed publisher
    In order to study fungal pathogen evolution, we used a model system whereby the opportunistic fungus Aspergillus flavus was serially propagated through the insect (Galleria mellonella) larvae, yielding a cysteine/methionine auxotroph of A...

Detail Information

Publications97

  1. Abbas H, Zablotowicz R, Horn B, Phillips N, Johnson B, Jin X, et al. Comparison of major biocontrol strains of non-aflatoxigenic Aspergillus flavus for the reduction of aflatoxins and cyclopiazonic acid in maize. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2011;28:198-208 pubmed publisher
    Biological control of toxigenic Aspergillus flavus in maize through competitive displacement by non-aflatoxigenic strains was evaluated in a series of field studies...
  2. Duan X, Jiang R, Wen Y, Bin J. Some 2S albumin from peanut seeds exhibits inhibitory activity against Aspergillus flavus. Plant Physiol Biochem. 2013;66:84-90 pubmed publisher
    ..Untreated 2S albumin had little inhibitory activity against trypsin, spore germination, or hyphal growth of Aspergillus flavus. However, following treatment of 2S albumin with SDS, increased inhibitory activity was demonstrated...
  3. Baker R, Brown R, Chen Z, Cleveland T, Fakhoury A. A maize lectin-like protein with antifungal activity against Aspergillus flavus. J Food Prot. 2009;72:120-7 pubmed
    The filamentous fungus Aspergillus flavus causes an ear rot on maize and produces a mycotoxin (aflatoxin) in colonized maize kernels. Aflatoxins are carcinogenic to humans and animals upon ingestion...
  4. Brun S, Fekkar A, Busse A, Seilhean D, Lecso M, Adler D, et al. Aspergillus flavus brain abscesses associated with hepatic amebiasis in a non-neutropenic man in Senegal. Am J Trop Med Hyg. 2009;81:583-6 pubmed publisher
    ..Surprisingly, the post-mortem examinations of brain abscesses showed Aspergillus flavus. The route of infection by A. flavus in this particular context is discussed.
  5. Andleeb S, Atiq N, Robson G, Ahmed S. An investigation of anthraquinone dye biodegradation by immobilized Aspergillus flavus in fluidized bed bioreactor. Environ Sci Pollut Res Int. 2012;19:1728-37 pubmed publisher
    Biodegradation and biodecolorization of Drimarene blue K(2)RL (anthraquinone) dye by a fungal isolate Aspergillus flavus SA2 was studied in lab-scale immobilized fluidized bed bioreactor (FBR) system. Fungus was immobilized on 0...
  6. Mousa W, Ghazali F, Jinap S, Ghazali H, Radu S. Modelling the effect of water activity and temperature on growth rate and aflatoxin production by two isolates of Aspergillus flavus on paddy. J Appl Microbiol. 2011;111:1262-74 pubmed publisher
    This study was conducted to characterize the growth of and aflatoxin production by Aspergillus flavus on paddy and to develop kinetic models describing the growth rate as a function of water activity (a(w)) and temperature...
  7. Leema G, Kaliamurthy J, Geraldine P, Thomas P. Keratitis due to Aspergillus flavus: clinical profile, molecular identification of fungal strains and detection of aflatoxin production. Mol Vis. 2010;16:843-54 pubmed
    To document the clinical profile of patients with keratitis due to Aspergillus flavus and to elaborate on differences in the aflatoxin-producing potential of keratitis strains versus environmental strains of A. flavus...
  8. Chang P, Scharfenstein L, Li P, Ehrlich K. Aspergillus flavus VelB acts distinctly from VeA in conidiation and may coordinate with FluG to modulate sclerotial production. Fungal Genet Biol. 2013;58-59:71-9 pubmed publisher
    ..VeA and VelB of A. nidulans and Aspergillus fumigatus also are repressors of conidiation, but VeA of Aspergillus flavus in studied strains acts positively on conidiation...
  9. Nogueira J, Gonçalez E, Galleti S, Facanali R, Marques M, Felicio J. Ageratum conyzoides essential oil as aflatoxin suppressor of Aspergillus flavus. Int J Food Microbiol. 2010;137:55-60 pubmed publisher
    ..effects of essential oil of Ageratum conyzoides, on the mycelial growth and aflatoxin B(1) production by Aspergillus flavus were studied...
  10. Scully L, Bidochka M. An alternative insect pathogenic strategy in an Aspergillus flavus auxotroph. Mycol Res. 2009;113:230-9 pubmed publisher
    In order to study fungal pathogen evolution, we used a model system whereby the opportunistic fungus Aspergillus flavus was serially propagated through the insect (Galleria mellonella) larvae, yielding a cysteine/methionine auxotroph of A...
  11. Chang K, Muddiman D. Identification of alternative splice variants in Aspergillus flavus through comparison of multiple tandem MS search algorithms. BMC Genomics. 2011;12:358 pubmed publisher
    ..by using an alternative splicing database, we identified more proteins than with the annotated proteins in Aspergillus flavus. In this study, we aimed at finding a greater number of eligible splice variants based on newly available ..
  12. Gonçalves S, Cano J, Stchigel A, Melo A, Godoy Martinez P, Correa B, et al. Molecular phylogeny and phenotypic variability of clinical and environmental strains of Aspergillus flavus. Fungal Biol. 2012;116:1146-55 pubmed publisher
    b>Aspergillus flavus is the second most common cause of aspergillosis infection in immunocompromised patients and is responsible for the production of aflatoxins. Little is known about the population structure of A...
  13. Ramírez Camejo L, Zuluaga Montero A, Lázaro Escudero M, Hernández Kendall V, Bayman P. Phylogeography of the cosmopolitan fungus Aspergillus flavus: is everything everywhere?. Fungal Biol. 2012;116:452-63 pubmed publisher
    b>Aspergillus flavus is one of the most common fungal eukaryotes on the planet. It is notorious for production of aflatoxins, for causing aspergillosis in humans and animals, and as an opportunistic pathogen of animals and plants...
  14. Chang P, Ehrlich K. Genome-wide analysis of the Zn(II)?Cys? zinc cluster-encoding gene family in Aspergillus flavus. Appl Microbiol Biotechnol. 2013;97:4289-300 pubmed publisher
    ..b>Aspergillus flavus is a saprophytic soil fungus that can produce the carcinogenic aflatoxin...
  15. Chu Y, Faustinelli P, Ramos M, Hajduch M, Stevenson S, Thelen J, et al. Reduction of IgE binding and nonpromotion of Aspergillus flavus fungal growth by simultaneously silencing Ara h 2 and Ara h 6 in peanut. J Agric Food Chem. 2008;56:11225-33 pubmed publisher
    ..Data collected from in vitro Aspergillus flavus infection indicate no significant difference in fungal growth between the transgenic lines and the ..
  16. Chang P, Abbas H, Weaver M, Ehrlich K, Scharfenstein L, Cotty P. Identification of genetic defects in the atoxigenic biocontrol strain Aspergillus flavus K49 reveals the presence of a competitive recombinant group in field populations. Int J Food Microbiol. 2012;154:192-6 pubmed publisher
    ..A current biocontrol strategy is to use non-aflatoxigenic Aspergillus flavus strains to competitively exclude field toxigenic Aspergillus species. A...
  17. Rudramurthy S, Chakrabarti A, Geertsen E, Mouton J, Meis J. In vitro activity of isavuconazole against 208 Aspergillus flavus isolates in comparison with 7 other antifungal agents: assessment according to the methodology of the European Committee on Antimicrobial Susceptibility Testing. Diagn Microbiol Infect Dis. 2011;71:370-7 pubmed publisher
    b>Aspergillus flavus is the second most common species causing invasive aspergillosis after A. fumigatus. In certain countries like India, Sudan, and Saudi Arabia, A...
  18. Batista P, Santos J, Oliveira N, Pires A, Motta C, Luna Alves Lima E. Genetic characterization of Brazilian strains of Aspergillus flavus using DNA markers. Genet Mol Res. 2008;7:706-17 pubmed
    ..polymorphic DNA (RAPD) molecular markers were used, with the aim of genetically characterizing strains of Aspergillus flavus and strains of other species of the A. flavus group...
  19. Calvo E, Pastor F, Salas V, Mayayo E, Guarro J. Combined therapy of voriconazole and anidulafungin in murine infections by Aspergillus flavus. Mycopathologia. 2012;173:251-7 pubmed publisher
    ..1 mg/kg plus voriconazole (VRC) at 25 mg/kg was evaluated in a murine model of disseminated infection by Aspergillus flavus using three isolates previously tested in vitro...
  20. Chang P, Scharfenstein L, Luo M, Mahoney N, Molyneux R, Yu J, et al. Loss of msnA, a putative stress regulatory gene, in Aspergillus parasiticus and Aspergillus flavus increased production of conidia, aflatoxins and kojic acid. Toxins (Basel). 2011;3:82-104 pubmed publisher
    Production of the harmful carcinogenic aflatoxins by Aspergillus parasiticus and Aspergillus flavus has been postulated to be a mechanism to relieve oxidative stress. The msnA gene of A. parasiticus and A...
  21. Huang J, Jiang H, Zhou Y, Lei Y, Wang S, Liao B. Ethylene inhibited aflatoxin biosynthesis is due to oxidative stress alleviation and related to glutathione redox state changes in Aspergillus flavus. Int J Food Microbiol. 2009;130:17-21 pubmed publisher
    ..ROS) formation, cellular redox status, and enzymes involved in glutathione consumption and regeneration in Aspergillus flavus was investigated. The results demonstrated that CEPA dose dependently inhibited aflatoxin B(1) production...
  22. Chang P, Ehrlich K. What does genetic diversity of Aspergillus flavus tell us about Aspergillus oryzae?. Int J Food Microbiol. 2010;138:189-99 pubmed publisher
    b>Aspergillus flavus and Aspergillus oryzae belong to Aspergillus section Flavi. They are closely related and are of significant economic importance...
  23. Rodrigues P, Venancio A, Kozakiewicz Z, Lima N. A polyphasic approach to the identification of aflatoxigenic and non-aflatoxigenic strains of Aspergillus Section Flavi isolated from Portuguese almonds. Int J Food Microbiol. 2009;129:187-93 pubmed publisher
    ..isolates (42%) had yellow-green colonies and smooth to finely rough globose conidia, and were classified as Aspergillus flavus. Chemical characterization involved the screening of the isolates for aflatoxins B (AFB) and G (AFG), and ..
  24. Wang D, Hadj Henni L, Thierry S, Arné P, Chermette R, Botterel F, et al. Simple and highly discriminatory VNTR-based multiplex PCR for tracing sources of Aspergillus flavus isolates. PLoS ONE. 2012;7:e44204 pubmed publisher
    b>Aspergillus flavus is second only to A. fumigatus in causing invasive aspergillosis and it is the major agent responsible for fungal sinusitis, keratitis and endophthalmitis in many countries in the Middle East, Africa and Southeast Asia...
  25. Pechanova O, Pechan T, Williams W, Luthe D. Proteomic analysis of the maize rachis: potential roles of constitutive and induced proteins in resistance to Aspergillus flavus infection and aflatoxin accumulation. Proteomics. 2011;11:114-27 pubmed publisher
    Infection of the maize (Zea mays L.) with aflatoxigenic fungus Aspergillus flavus and consequent contamination with carcinogenic aflatoxin is a persistent and serious agricultural problem causing disease and significant crop losses ..
  26. Mauro A, Battilani P, Callicott K, Giorni P, Pietri A, Cotty P. Structure of an Aspergillus flavus population from maize kernels in northern Italy. Int J Food Microbiol. 2013;162:1-7 pubmed publisher
    In order to gain insight into the causal agents of aflatoxin contamination of maize in Italy, populations of Aspergillus flavus on maize produced in the most affected area were characterized. Forty-six percent of A...
  27. Chang P, Scharfenstein L, Wei Q, Bhatnagar D. Development and refinement of a high-efficiency gene-targeting system for Aspergillus flavus. J Microbiol Methods. 2010;81:240-6 pubmed publisher
    ..of the nonhomologous end-joining pathway and the orotidine monophosphate decarboxylase gene (pyrG) in Aspergillus flavus was established...
  28. Wang T, Zhang E, Chen X, Li L, Liang X. Identification of seed proteins associated with resistance to pre-harvested aflatoxin contamination in peanut (Arachis hypogaea L). BMC Plant Biol. 2010;10:267 pubmed publisher
    Pre-harvest infection of peanuts by Aspergillus flavus and subsequent aflatoxin contamination is one of the food safety factors that most severely impair peanut productivity and human and animal health, especially in arid and semi-arid ..
  29. Xie Y, Chen Z, Brown R, Bhatnagar D. Expression and functional characterization of two pathogenesis-related protein 10 genes from Zea mays. J Plant Physiol. 2010;167:121-30 pubmed publisher
    ..darkness and wounding during the 16-h treatments, and biotic stresses such as Erwinia stewartii and Aspergillus flavus infection. However, ZmPR10...
  30. Abbas H, Accinelli C, Zablotowicz R, Abel C, Bruns H, Dong Y, et al. Dynamics of mycotoxin and Aspergillus flavus levels in aging Bt and non-Bt corn residues under Mississippi no-till conditions. J Agric Food Chem. 2008;56:7578-85 pubmed publisher
    Mycotoxin and Aspergillus flavus levels in soil-surface corn debris left by no-till agriculture methods (stover, cobs, and cobs with grain) were determined during the December-March fallow period for near-isogenic Bt and non-Bt hybrid ..
  31. Ehrlich K, Chang P, Scharfenstein L, Cary J, Crawford J, Townsend C. Absence of the aflatoxin biosynthesis gene, norA, allows accumulation of deoxyaflatoxin B1 in Aspergillus flavus cultures. FEMS Microbiol Lett. 2010;305:65-70 pubmed publisher
    ..that the aryl alcohol dehydrogenase NorA (AflE) encoded by the aflatoxin biosynthetic gene cluster in Aspergillus flavus affects the accumulation of aflatoxins in the final steps of aflatoxin biosynthesis...
  32. Sindhu S, Chempakam B, Leela N, Suseela Bhai R. Chemoprevention by essential oil of turmeric leaves (Curcuma longa L.) on the growth of Aspergillus flavus and aflatoxin production. Food Chem Toxicol. 2011;49:1188-92 pubmed publisher
    ..1, 0.5, 0.75, 1.0 and 1.5% (v/v) in Yeast Extract Sucrose (YES) broth inoculated with spore suspension of Aspergillus flavus of 10(6)conidia/ml. These were evaluated for their potential in the control of aflatoxigenic fungus A...
  33. Affeldt K, Brodhagen M, Keller N. Aspergillus oxylipin signaling and quorum sensing pathways depend on g protein-coupled receptors. Toxins (Basel). 2012;4:695-717 pubmed publisher
    ..The finding of GPCRs that regulate production of survival structures (sclerotia), inoculum (spores) and aflatoxin holds promise for future development of anti-fungal therapeutics. ..
  34. Shivaprakash M, Geertsen E, Chakrabarti A, Mouton J, Meis J. In vitro susceptibility of 188 clinical and environmental isolates of Aspergillus flavus for the new triazole isavuconazole and seven other antifungal drugs. Mycoses. 2011;54:e583-9 pubmed publisher
    ..Recently isavuconazole, an experimental triazole agent, was found to be active against Aspergillus species. As Aspergillus flavus is the second-most common Aspergillus species isolated from human infection and the fungus has not been ..
  35. Chang P, Scharfenstein L, Ehrlich K, Wei Q, Bhatnagar D, Ingber B. Effects of laeA deletion on Aspergillus flavus conidial development and hydrophobicity may contribute to loss of aflatoxin production. Fungal Biol. 2012;116:298-307 pubmed publisher
    ..We found that although Aspergillus flavus CA14 laeA deletion mutants showed no aflatoxin production, expression of some of the early genes involved in ..
  36. Liu S, Lin J, Wu H, Wang C, Huang S, Luo Y, et al. Bisulfite sequencing reveals that Aspergillus flavus holds a hollow in DNA methylation. PLoS ONE. 2012;7:e30349 pubmed publisher
    b>Aspergillus flavus first gained scientific attention for its production of aflatoxin. The underlying regulation of aflatoxin biosynthesis has been serving as a theoretical model for biosynthesis of other microbial secondary metabolites...
  37. Chen Z, Brown R, Damann K, Cleveland T. PR10 expression in maize and its effect on host resistance against Aspergillus flavus infection and aflatoxin production. Mol Plant Pathol. 2010;11:69-81 pubmed publisher
    Maize (Zea mays L.) is a major crop susceptible to Aspergillus flavus infection and subsequent contamination with aflatoxins, the potent carcinogenic secondary metabolites of the fungus...
  38. Cary J, Rajasekaran K, Brown R, Luo M, Chen Z, Bhatnagar D. Developing resistance to aflatoxin in maize and cottonseed. Toxins (Basel). 2011;3:678-96 pubmed publisher
    ..This review will present information on preharvest control strategies that utilize both breeding and native resistance identification approaches in maize as well as transgenic approaches in cotton...
  39. Gandomi H, Misaghi A, Basti A, Bokaei S, Khosravi A, Abbasifar A, et al. Effect of Zataria multiflora Boiss. essential oil on growth and aflatoxin formation by Aspergillus flavus in culture media and cheese. Food Chem Toxicol. 2009;47:2397-400 pubmed publisher
    ..essential oil (EO) against growth, spore production and aflatoxin formation by Aspergillus flavus ATCC 15546 was investigated in synthetic media as well as Iranian ultra-filtered white cheese in brine...
  40. Yu J, Fedorova N, Montalbano B, Bhatnagar D, Cleveland T, Bennett J, et al. Tight control of mycotoxin biosynthesis gene expression in Aspergillus flavus by temperature as revealed by RNA-Seq. FEMS Microbiol Lett. 2011;322:145-9 pubmed publisher
    ..understand the effect of temperature on mycotoxin biosynthesis, RNA-Seq technology was used to profile the Aspergillus flavus transcriptome under different temperature conditions...
  41. Kale S, Milde L, Trapp M, Frisvad J, Keller N, Bok J. Requirement of LaeA for secondary metabolism and sclerotial production in Aspergillus flavus. Fungal Genet Biol. 2008;45:1422-9 pubmed publisher
    ..Herein we examine the role of this protein in Aspergillus flavus. Similarly as in other Aspergilli, LaeA had a major effect on A...
  42. Amaike S, Keller N. Distinct roles for VeA and LaeA in development and pathogenesis of Aspergillus flavus. Eukaryot Cell. 2009;8:1051-60 pubmed publisher
    b>Aspergillus flavus, a mycotoxigenic filamentous fungus, colonizes several important agricultural crops, such as maize and peanuts...
  43. Tran Dinh N, Kennedy I, Bui T, Carter D. Survey of Vietnamese peanuts, corn and soil for the presence of Aspergillus flavus and Aspergillus parasiticus. Mycopathologia. 2009;168:257-68 pubmed publisher
    b>Aspergillus flavus and Aspergillus parasiticus cause perennial infection of agriculturally important crops in tropical and subtropical areas...
  44. Ferreira F, Kemmelmeier C, Arrotéia C, da Costa C, Mallmann C, Janeiro V, et al. Inhibitory effect of the essential oil of Curcuma longa L. and curcumin on aflatoxin production by Aspergillus flavus Link. Food Chem. 2013;136:789-93 pubmed publisher
    ..The levels of aflatoxin B(1) (AFB(1)) production were 1.0 and 42.7 ?g/mL, respectively, for the samples treated with the essential oil of C. longa L. and curcumin at a concentration of 0.5%...
  45. Schmidt Heydt M, Abdel Hadi A, Magan N, Geisen R. Complex regulation of the aflatoxin biosynthesis gene cluster of Aspergillus flavus in relation to various combinations of water activity and temperature. Int J Food Microbiol. 2009;135:231-7 pubmed publisher
    ..These two groups were co-ordinately localized within the aflatoxin gene cluster. The ratio of aflR/aflJ expression was correlated with increased aflatoxin biosynthesis...
  46. Yu J, Payne G, Nierman W, Machida M, Bennett J, Campbell B, et al. Aspergillus flavus genomics as a tool for studying the mechanism of aflatoxin formation. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008;25:1152-7 pubmed
    b>Aspergillus flavus is a weak pathogen that infects plants, animals and humans. When it infects agricultural crops, however, it produces one of the most potent carcinogens known (aflatoxins)...
  47. Tripathi V, Kumar S, Garg S. A study on trypsin, Aspergillus flavus and Bacillus sp. protease inhibitory activity in Cassia tora (L.) syn Senna tora (L.) Roxb. seed extract. BMC Complement Altern Med. 2011;11:56 pubmed publisher
    ..The present study explores the protease inhibitory activity of the above plant seeds against trypsin, Aspergillus flavus and Bacillus sp. proteases.
  48. Kelley R, Gresham C, Harper J, Bridges S, Warburton M, Hawkins L, et al. Integrated database for identifying candidate genes for Aspergillus flavus resistance in maize. BMC Bioinformatics. 2010;11 Suppl 6:S25 pubmed publisher
    b>Aspergillus flavus Link:Fr, an opportunistic fungus that produces aflatoxin, is pathogenic to maize and other oilseed crops. Aflatoxin is a potent carcinogen, and its presence markedly reduces the value of grain...
  49. Jain N, Bhargava A, Majumdar S, Tarafdar J, Panwar J. Extracellular biosynthesis and characterization of silver nanoparticles using Aspergillus flavus NJP08: a mechanism perspective. Nanoscale. 2011;3:635-41 pubmed publisher
    ..an eco-friendly and low cost protocol for synthesis of silver nanoparticles using the cell-free filtrate of Aspergillus flavus NJP08 when supplied with aqueous silver (Ag+) ions...
  50. Lin J, Zhao X, Zhi Q, Zhao M, He Z. Transcriptomic profiling of Aspergillus flavus in response to 5-azacytidine. Fungal Genet Biol. 2013;56:78-86 pubmed publisher
    b>Aspergillus flavus is a common saprophyte and opportunistic pathogen producing aflatoxin (AF) and many other secondary metabolites...
  51. Horowitz Brown S, Zarnowski R, Sharpee W, Keller N. Morphological transitions governed by density dependence and lipoxygenase activity in Aspergillus flavus. Appl Environ Microbiol. 2008;74:5674-85 pubmed publisher
    b>Aspergillus flavus differentiates to produce asexual dispersing spores (conidia) or overwintering survival structures called sclerotia...
  52. Krishnan Natesan S, Chandrasekar P, Alangaden G, Manavathu E. Molecular characterisation of cyp51A and cyp51B genes coding for P450 14alpha-lanosterol demethylases A (CYP51Ap) and B (CYP51Bp) from voriconazole-resistant laboratory isolates of Aspergillus flavus. Int J Antimicrob Agents. 2008;32:519-24 pubmed publisher
    b>Aspergillus flavus is the second most common Aspergillus spp. causing invasive infections in immunocompromised patients...
  53. Probst C, Schulthess F, Cotty P. Impact of Aspergillus section Flavi community structure on the development of lethal levels of aflatoxins in Kenyan maize (Zea mays). J Appl Microbiol. 2010;108:600-10 pubmed publisher
  54. Cary J, Harris Coward P, Ehrlich K, Mack B, Kale S, Larey C, et al. NsdC and NsdD affect Aspergillus flavus morphogenesis and aflatoxin production. Eukaryot Cell. 2012;11:1104-11 pubmed publisher
    ..also play a role in asexual development in the agriculturally important aflatoxin (AF)-producing fungus Aspergillus flavus. We found that both NsdC and NsdD are required for production of asexual sclerotia, normal aflatoxin ..
  55. El Khoury A, Atoui A, Rizk T, Lteif R, Kallassy M, Lebrihi A. Differentiation between Aspergillus flavus and Aspergillus parasiticus from pure culture and aflatoxin-contaminated grapes using PCR-RFLP analysis of aflR-aflJ intergenic spacer. J Food Sci. 2011;76:M247-53 pubmed publisher
    ..They are produced mainly by Aspergillus flavus and A. parasiticus. Both species have different aflatoxinogenic profile. In order to distinguish between A...
  56. Chang P, Horn B, Dorner J. Clustered genes involved in cyclopiazonic acid production are next to the aflatoxin biosynthesis gene cluster in Aspergillus flavus. Fungal Genet Biol. 2009;46:176-82 pubmed publisher
    ..In addition to CPA Aspergillus flavus produces polyketide-derived carcinogenic aflatoxins...
  57. Tian J, Ban X, Zeng H, He J, Chen Y, Wang Y. The mechanism of antifungal action of essential oil from dill (Anethum graveolens L.) on Aspergillus flavus. PLoS ONE. 2012;7:e30147 pubmed publisher
    ..of the antifungal action further, the effect of the essential oil on the plasma membrane and mitochondria of Aspergillus flavus was investigated...
  58. Nicholson M, Koulman A, Monahan B, Pritchard B, Payne G, Scott B. Identification of two aflatrem biosynthesis gene loci in Aspergillus flavus and metabolic engineering of Penicillium paxilli to elucidate their function. Appl Environ Microbiol. 2009;75:7469-81 pubmed publisher
    Aflatrem is a potent tremorgenic toxin produced by the soil fungus Aspergillus flavus, and a member of a structurally diverse group of fungal secondary metabolites known as indole-diterpenes...
  59. Smith C, Robertson D, Yates B, Nielsen D, Brown D, Dean R, et al. The effect of temperature on Natural Antisense Transcript (NAT) expression in Aspergillus flavus. Curr Genet. 2008;54:241-69 pubmed publisher
    ..Analysis of currently available EST sequences suggests that 352 cis NATs are present in Aspergillus flavus. An Affymetrix GeneChip microarray containing probes for these cis NATs, as well as all predicted genes in A...
  60. Kelley R, Williams W, Mylroie J, Boykin D, Harper J, Windham G, et al. Identification of maize genes associated with host plant resistance or susceptibility to Aspergillus flavus infection and aflatoxin accumulation. PLoS ONE. 2012;7:e36892 pubmed publisher
    b>Aspergillus flavus infection and aflatoxin contamination of maize pose negative impacts in agriculture and health. Commercial maize hybrids are generally susceptible to this fungus...
  61. Grubisha L, Cotty P. Genetic isolation among sympatric vegetative compatibility groups of the aflatoxin-producing fungus Aspergillus flavus. Mol Ecol. 2010;19:269-80 pubmed publisher
    b>Aspergillus flavus, a fungal pathogen of animals and both wild and economically important plants, is most recognized for producing aflatoxin, a cancer-causing secondary metabolite that contaminates food and animal feed globally...
  62. Hadrich I, Makni F, Ayadi A, Ranque S. Microsatellite typing to trace Aspergillus flavus infections in a hematology unit. J Clin Microbiol. 2010;48:2396-401 pubmed publisher
    ..environment is instrumental in documenting the source of preventable health care-associated life-threatening Aspergillus flavus human infection clusters...
  63. Hadrich I, Makni F, Neji S, Cheikhrouhou F, Bellaaj H, Elloumi M, et al. Amphotericin B in vitro resistance is associated with fatal Aspergillus flavus infection. Med Mycol. 2012;50:829-34 pubmed publisher
    ..To do so, we determined the in vitro susceptibility to amphotericin B (AMB) of 37 Aspergillus flavus isolates from 14 patients with haematological malignancies diagnosed with proven or probable IA, of which 13 ..
  64. Pasqualotto A. Differences in pathogenicity and clinical syndromes due to Aspergillus fumigatus and Aspergillus flavus. Med Mycol. 2009;47 Suppl 1:S261-70 pubmed publisher
    ..flavus spores, in comparison to those of A. fumigatus spores, may favour their deposit in the upper respiratory tract. Differences between these species justify the need for a better understanding of A. flavus infections...
  65. Abdel Hadi A, Carter D, Magan N. Temporal monitoring of the nor-1 (aflD) gene of Aspergillus flavus in relation to aflatoxin B? production during storage of peanuts under different water activity levels. J Appl Microbiol. 2010;109:1914-22 pubmed publisher
    ..system (RQ-PCR) was used to monitor the correlations between the activity of the nor-1 (=aflD) gene of Aspergillus flavus using real-time PCR in relation to phenotypic aflatoxin B(1) (AFB(1) ) production and populations of A...
  66. de Oliveira Pedro R, Takaki M, Gorayeb T, Del Bianchi V, Thomeo J, Tiera M, et al. Synthesis, characterization and antifungal activity of quaternary derivatives of chitosan on Aspergillus flavus. Microbiol Res. 2013;168:50-5 pubmed publisher
    ..1)H NMR and potentiometric titration techniques and their antifungal activities on the mycelial growth of Aspergillus flavus were investigated in vitro...
  67. De Lucca A, Carter Wientjes C, Boue S, Bhatnagar D. Volatile?trans-2-hexenal, a soybean aldehyde, inhibits?Aspergillus flavus?growth and aflatoxin production in corn. J Food Sci. 2011;76:M381-6 pubmed publisher
    ..In vitro?tests showed it significantly (P?< 0.001) reduced?Aspergillus flavus?germinating conidial viability at 10 ?M, with approximately 95% viability reduction observed at 20 ?M...
  68. Krishnan S, Manavathu E, Chandrasekar P. Aspergillus flavus: an emerging non-fumigatus Aspergillus species of significance. Mycoses. 2009;52:206-22 pubmed publisher
    ..The second most frequent (approximately 15-20%) pathogenic species is Aspergillus flavus and to a lesser extent, Aspergillus niger and Aspergillus terreus...
  69. Leema G, Chou D, Jesudasan C, Geraldine P, Thomas P. Expression of genes of the aflatoxin biosynthetic pathway in Aspergillus flavus isolates from keratitis. Mol Vis. 2011;17:2889-97 pubmed
    To document transcriptional activation (expression) of key aflatoxin biosynthetic pathway genes in corneal isolates of Aspergillus flavus.
  70. Horn B, Moore G, Carbone I. Sexual reproduction in Aspergillus flavus. Mycologia. 2009;101:423-9 pubmed
    b>Aspergillus flavus is the major producer of carcinogenic aflatoxins in crops worldwide and is also an important opportunistic human pathogen in aspergillosis...
  71. Warburton M, Williams W, Hawkins L, Bridges S, Gresham C, Harper J, et al. A public platform for the verification of the phenotypic effect of candidate genes for resistance to aflatoxin accumulation and Aspergillus flavus infection in maize. Toxins (Basel). 2011;3:754-65 pubmed publisher
    A public candidate gene testing pipeline for resistance to aflatoxin accumulation or Aspergillus flavus infection in maize is presented here...
  72. Yin Y, Lou T, Yan L, Michailides T, Ma Z. Molecular characterization of toxigenic and atoxigenic Aspergillus flavus isolates, collected from peanut fields in China. J Appl Microbiol. 2009;107:1857-65 pubmed publisher
    ..of this study were to assess the genetic relationships between toxigenic and atoxigenic isolates of Aspergillus flavus collected from peanut fields in China, and to analyse deletions within the aflatoxin biosynthetic gene ..
  73. Guo B, Fedorova N, Chen X, Wan C, Wang W, Nierman W, et al. Gene expression profiling and identification of resistance genes to Aspergillus flavus infection in peanut through EST and microarray strategies. Toxins (Basel). 2011;3:737-53 pubmed publisher
    b>Aspergillus flavus and A. parasiticus infect peanut seeds and produce aflatoxins, which are associated with various diseases in domestic animals and humans throughout the world...
  74. Amaike S, Keller N. Aspergillus flavus. Annu Rev Phytopathol. 2011;49:107-33 pubmed publisher
    b>Aspergillus flavus is saprophytic soil fungus that infects and contaminates preharvest and postharvest seed crops with the carcinogenic secondary metabolite aflatoxin...
  75. Moore G, Singh R, Horn B, Carbone I. Recombination and lineage-specific gene loss in the aflatoxin gene cluster of Aspergillus flavus. Mol Ecol. 2009;18:4870-87 pubmed publisher
    Aflatoxins produced by Aspergillus flavus are potent carcinogens that contaminate agricultural crops. Recent efforts to reduce aflatoxin concentrations in crops have focused on biological control using nonaflatoxigenic A...
  76. Das M, Ehrlich K, Cotty P. Use of pyrosequencing to quantify incidence of a specific Aspergillus flavus strain within complex fungal communities associated with commercial cotton crops. Phytopathology. 2008;98:282-8 pubmed publisher
    Atoxigenic strains of Aspergillus flavus have been used as aflatoxin management tools on over 50,000 hectares of commercial crops since 2000...
  77. Luo M, Brown R, Chen Z, Menkir A, Yu J, Bhatnagar D. Transcriptional profiles uncover Aspergillus flavus-induced resistance in maize kernels. Toxins (Basel). 2011;3:766-86 pubmed publisher
    ..Comparisons between the resistant and susceptible lines indicate differences in the gene expression network which may enhance our understanding of the maize-A. flavus interaction...
  78. Abdel Hadi A, Schmidt Heydt M, Parra R, Geisen R, Magan N. A systems approach to model the relationship between aflatoxin gene cluster expression, environmental factors, growth and toxin production by Aspergillus flavus. J R Soc Interface. 2012;9:757-67 pubmed publisher
    ..995-0.90) and temperature (20-42°C) on the activation of aflatoxin biosynthetic genes (30 genes) in Aspergillus flavus grown on a conducive YES (20 g yeast extract, 150 g sucrose, 1 g MgSO(4)·7H(2)O) medium...
  79. Hua S, McAlpin C, Chang P, Sarreal S. Characterization of aflatoxigenic and non-aflatoxigenic Aspergillus flavus isolates from pistachio. Mycotoxin Res. 2012;28:67-75 pubmed publisher
    ..Thirty-eight Aspergillus flavus isolates collected from a pistachio orchard in California (CA) were analyzed for production of aflatoxin (AF)..
  80. Ozhak Baysan B, Alastruey Izquierdo A, Saba R, Ogunc D, Ongut G, Timuragaoglu A, et al. Aspergillus alliaceus and Aspergillus flavus co-infection in an acute myeloid leukemia patient. Med Mycol. 2010;48:995-9 pubmed publisher
    We report a case of a pulmonary infection caused by Aspergillus flavus and Aspergillus alliaceus in an acute myeloid leukemia patient. These isolates were identified using traditional and sequencing-based molecular methods.
  81. Al Wathiqi F, Ahmad S, Khan Z. Molecular identification and antifungal susceptibility profile of Aspergillus flavus isolates recovered from clinical specimens in Kuwait. BMC Infect Dis. 2013;13:126 pubmed publisher
    ..is a cause of concern for treatment of patients with invasive aspergillosis. In this study we present data on genetic characterization and antifungal susceptibility profile of clinical and environmental isolates of A. flavus...
  82. Mellon J, Zelaya C, Dowd M. Inhibitory effects of gossypol-related compounds on growth of Aspergillus flavus. Lett Appl Microbiol. 2011;52:406-12 pubmed publisher
    The objective of this study was to test a series of gossypol-related compounds for growth inhibition against Aspergillus flavus.
  83. Li D, Xiu D, Li R, Samson R, de Hoog G, Wang D. Aspergillus flavus myositis in a patient after liver transplantation. Clin Transplant. 2008;22:508-11 pubmed
    We describe the first case of Aspergillus myositis caused by Aspergillus flavus in a liver transplant patient. The patient was a 43-year-old man who underwent liver transplantation because of end-stage hepatic cirrhosis...
  84. Hadrich I, Neji S, Drira I, Trabelsi H, Mahfoud N, Ranque S, et al. Microsatellite typing of Aspergillus flavus in patients with various clinical presentations of aspergillosis. Med Mycol. 2013;51:586-91 pubmed publisher
    b>Aspergillus flavus is the second most important Aspergillus species associated with aspergillosis and the incidence of infections caused by it are increasing in the immunocompromised population...
  85. Baker R, Brown R, Chen Z, Cleveland T, Fakhoury A. A maize trypsin inhibitor (ZmTIp) with limited activity against Aspergillus flavus. J Food Prot. 2009;72:185-8 pubmed
    Infection of maize both pre- and postharvest by Aspergillus flavus is a severe agricultural problem in the southern United States. Aflatoxins are secondary metabolites produced by A...
  86. Gibbons J, Salichos L, Slot J, Rinker D, McGary K, King J, et al. The evolutionary imprint of domestication on genome variation and function of the filamentous fungus Aspergillus oryzae. Curr Biol. 2012;22:1403-9 pubmed publisher
    ..These results suggest that whereas animal and plant domestication was largely driven by Neolithic "genetic tinkering" of developmental pathways, microbe domestication was driven by extensive remodeling of metabolism...
  87. Georgianna D, Fedorova N, Burroughs J, Dolezal A, Bok J, Horowitz Brown S, et al. Beyond aflatoxin: four distinct expression patterns and functional roles associated with Aspergillus flavus secondary metabolism gene clusters. Mol Plant Pathol. 2010;11:213-26 pubmed publisher
    ..It has been possible to infer the presence of 55 gene clusters associated with secondary metabolism in Aspergillus flavus; however, only three metabolic pathways-aflatoxin, cyclopiazonic acid (CPA) and aflatrem-have been assigned ..
  88. Sudhakar P, Latha P, Sreenivasulu Y, Reddy B, Hemalatha T, Balakrishna M, et al. Inhibition of Aspergillus flavus colonization and aflatoxin (AfB1) in peanut by methyleugenol. Indian J Exp Biol. 2009;47:63-7 pubmed
    ..flavus and aflatoxin synthesis. This chemical can be used as both prophylactic or post infection spray on peanut pods before storage. It is the first report on the inhibition of A. flavus by methyleugenol on peanut...
  89. Olarte R, Horn B, Dorner J, Monacell J, Singh R, Stone E, et al. Effect of sexual recombination on population diversity in aflatoxin production by Aspergillus flavus and evidence for cryptic heterokaryosis. Mol Ecol. 2012;21:1453-76 pubmed publisher
    b>Aspergillus flavus is the major producer of carcinogenic aflatoxins (AFs) in crops worldwide. Natural populations of A...
  90. Patel N, Damann K, Leonardi C, Sabliov C. Size dependency of PLGA-nanoparticle uptake and antifungal activity against Aspergillus flavus. Nanomedicine (Lond). 2011;6:1381-95 pubmed publisher
    ..Itraconazole and coumarin-6 loaded polylactic-co-glycolic acid-nanoparticles (PLGA-ITZ- and PLGA-C6-NPs) were synthesized and tested for fungal cell uptake and antifungal ability based on particle size...
  91. Yan S, Liang Y, Zhang J, Liu C. Aspergillus flavus grown in peptone as the carbon source exhibits spore density- and peptone concentration-dependent aflatoxin biosynthesis. BMC Microbiol. 2012;12:106 pubmed publisher
    ..It has been known for over 30 years that peptone is not conducive for AF productions, although reasons for this remain unknown...
  92. Etcheverry M, Scandolara A, Nesci A, Vilas Boas Ribeiro M, Pereira P, Battilani P. Biological interactions to select biocontrol agents against toxigenic strains of Aspergillus flavus and Fusarium verticillioides from maize. Mycopathologia. 2009;167:287-95 pubmed publisher
    ..A key to progress in biological control to protect maize against Fusarium verticillioides and Aspergillus flavus maize pathogens are, to select in vitro, the best agent to be applied in the field...
  93. Passone M, Ruffino M, Ponzio V, Resnik S, Etcheverry M. Postharvest control of peanut Aspergillus section Flavi populations by a formulation of food-grade antioxidants. Int J Food Microbiol. 2009;131:211-7 pubmed publisher
    ..200 kg of natural peanuts, while the other two (silos 3 and 4) had 200 kg of peanuts inoculated with Aspergillus flavus/A. parasiticus mixture (2 x 10(4) spores g(-1))...
  94. Xiong K, Liu H, Liu R, Li L. Differences in fungicidal efficiency against Aspergillus flavus for neutralized and acidic electrolyzed oxidizing waters. Int J Food Microbiol. 2010;137:67-75 pubmed publisher
    ..are electrolyzed oxidizing waters (EOW) that have significantly different fungicidal efficiencies against Aspergillus flavus (A...
  95. Mohammadipour M, Mousivand M, Salehi Jouzani G, Abbasalizadeh S. Molecular and biochemical characterization of Iranian surfactin-producing Bacillus subtilis isolates and evaluation of their biocontrol potential against Aspergillus flavus and Colletotrichum gloeosporioides. Can J Microbiol. 2009;55:395-404 pubmed publisher
    ..chromatography (HPLC) analyses, and the isolates' biocontrol effects against the aflatoxin-producing agent Aspergillus flavus and the citrus antracnosis agent Colletotrichum gloeosporioides were studied. In total, 290 B...
  96. Seshime Y, Juvvadi P, Tokuoka M, Koyama Y, Kitamoto K, Ebizuka Y, et al. Functional expression of the Aspergillus flavus PKS-NRPS hybrid CpaA involved in the biosynthesis of cyclopiazonic acid. Bioorg Med Chem Lett. 2009;19:3288-92 pubmed publisher
    ..This CpaA expression system provides us an ideal platform for PKS-NRPS functional analysis, such as adenylation domain selectivity and product releasing mechanism...