alternaria

Summary

Summary: A mitosporic Loculoascomycetes fungal genus including several plant pathogens and at least one species which produces a highly phytotoxic antibiotic. Its teleomorph is Lewia.

Top Publications

  1. Wang W, Wang Y, Tao H, Peng X, Liu P, Zhu W. Cerebrosides of the halotolerant fungus Alternaria raphani isolated from a sea salt field. J Nat Prod. 2009;72:1695-8 pubmed publisher
    ..and bioactive natural compounds from marine-derived fungi, a halotolerant fungal strain (THW-18) identified as Alternaria raphani was isolated from sediment collected in the Hongdao sea salt field...
  2. Kasahara K, Miyamoto T, Fujimoto T, Oguri H, Tokiwano T, Oikawa H, et al. Solanapyrone synthase, a possible Diels-Alderase and iterative type I polyketide synthase encoded in a biosynthetic gene cluster from Alternaria solani. Chembiochem. 2010;11:1245-52 pubmed publisher
    The solanapyrone biosynthetic gene cluster was cloned from Alternaria solani...
  3. Pogány M, von Rad U, Grün S, Dongo A, Pintye A, Simoneau P, et al. Dual roles of reactive oxygen species and NADPH oxidase RBOHD in an Arabidopsis-Alternaria pathosystem. Plant Physiol. 2009;151:1459-75 pubmed publisher
    ..Here, we present dual roles of RBOHD (for respiratory burst oxidase homolog D) in an Arabidopsis-Alternaria pathosystem, suggesting either initiation or prevention of cell death dependent on the distance from pathogen ..
  4. Wilson H, Carroll G, Roy B, Blaisdell G. Tall fescue is a potential spillover reservoir host for Alternaria species. Mycologia. 2014;106:22-31 pubmed publisher
    ..highly invasive grass species in North America, is a potential reservoir host for the ubiquitous genus of fungi, Alternaria. We also asked whether spillover of Alternaria is possible among grasses that commonly occur with S...
  5. Prelle A, Spadaro D, Garibaldi A, Gullino M. A new method for detection of five alternaria toxins in food matrices based on LC-APCI-MS. Food Chem. 2013;140:161-7 pubmed publisher
    ..AOH), alternariol monomethyl ether (AME), altenuene (ALT), tentoxin (TEN), and tenuazonic acid (TeA), five alternaria toxins (ATs) was developed by liquid chromatography-triple quadrupole mass spectrometry equipped with ..
  6. Song W, Ma X, Tan H, Zhou J. Abscisic acid enhances resistance to Alternaria solani in tomato seedlings. Plant Physiol Biochem. 2011;49:693-700 pubmed publisher
    ..and Alternaria solani (early blight). Foliar spraying of 7...
  7. Botanga C, Bethke G, Chen Z, Gallie D, Fiehn O, Glazebrook J. Metabolite profiling of Arabidopsis inoculated with Alternaria brassicicola reveals that ascorbate reduces disease severity. Mol Plant Microbe Interact. 2012;25:1628-38 pubmed publisher
    The interaction between the pathogenic ascomycete Alternaria brassicicola and Arabidopsis was investigated by metabolite profiling. The effect of A...
  8. Shin S, Ye Y, Eun Y, Kim S, Cho J, Park H. Local IgE-mediated hypersensitivity to Alternaria in pediatric adenoid tissue. Int J Pediatr Otorhinolaryngol. 2012;76:1423-8 pubmed publisher
    ..Several studies have demonstrated the presence of humoral immune responses to fungi, including Alternaria and Aspergillus, in patients with nasal polyposis, asthma, or rhinitis...
  9. Hashimoto M, Higuchi Y, Takahashi S, Osada H, Sakaki T, Toyomasu T, et al. Functional analyses of cytochrome P450 genes responsible for the early steps of brassicicene C biosynthesis. Bioorg Med Chem Lett. 2009;19:5640-3 pubmed publisher
    ..previously revealed that Orf8 and Orf6, which were identified in the brassicicene C biosynthetic gene cluster in Alternaria brassicicola strain ATCC96836, were fusicoccadiene (FD) synthase and 16-O-methyltransferase, respectively...

More Information

Publications80

  1. Ajiro N, Miyamoto Y, Masunaka A, Tsuge T, Yamamoto M, Ohtani K, et al. Role of the host-selective ACT-toxin synthesis gene ACTTS2 encoding an enoyl-reductase in pathogenicity of the tangerine pathotype of Alternaria alternata. Phytopathology. 2010;100:120-6 pubmed publisher
    ABSTRACT The tangerine pathotype of Alternaria alternata produces host-selective ACT-toxin and causes Alternaria brown spot disease of tangerines and tangerine hybrids...
  2. Rivas San Vicente M, Larios Zarate G, Plasencia J. Disruption of sphingolipid biosynthesis in Nicotiana benthamiana activates salicylic acid-dependent responses and compromises resistance to Alternaria alternata f. sp. lycopersici. Planta. 2013;237:121-36 pubmed publisher
    ..Interestingly, the virulence of two unrelated necrotrophic fungi, Fusarium verticillioides and Alternaria alternata, which are pathogens of maize and tomato plants, respectively, depends on the production of ..
  3. Andersen B, Sørensen J, Nielsen K, Gerrits van den Ende B, de Hoog S. A polyphasic approach to the taxonomy of the Alternaria infectoria species-group. Fungal Genet Biol. 2009;46:642-56 pubmed publisher
    Different taxa in the species-group of Alternaria infectoria (teleomorph Lewia spp.) are often isolated from various cereals including barley, maize and wheat grain, ornamental plants and skin lesions from animals and humans...
  4. Joubert A, Bataille Simoneau N, Campion C, Guillemette T, Hudhomme P, Iacomi Vasilescu B, et al. Cell wall integrity and high osmolarity glycerol pathways are required for adaptation of Alternaria brassicicola to cell wall stress caused by brassicaceous indolic phytoalexins. Cell Microbiol. 2011;13:62-80 pubmed publisher
    Camalexin, the characteristic phytoalexin of Arabidopsis thaliana, inhibits growth of the fungal necrotroph Alternaria brassicicola. This plant metabolite probably exerts its antifungal toxicity by causing cell membrane damage...
  5. Llorens E, Fernández Crespo E, Vicedo B, Lapeña L, García Agustín P. Enhancement of the citrus immune system provides effective resistance against Alternaria brown spot disease. J Plant Physiol. 2013;170:146-54 pubmed publisher
    ..In this work, we demonstrate the effectiveness of hexanoic acid (Hx) in the control of Alternaria brown spot (ABS) disease via enhancement of the immune system of Fortune mandarin...
  6. Lin C, Chung K. Specialized and shared functions of the histidine kinase- and HOG1 MAP kinase-mediated signaling pathways in Alternaria alternata, a filamentous fungal pathogen of citrus. Fungal Genet Biol. 2010;47:818-27 pubmed publisher
    Signal transduction pathways are critical for the coordination of complex cellular processes in cells. In Alternaria alternata, a necrotrophic fungal pathogen of citrus, cloning and characterization of a gene coding a Group III histidine ..
  7. Akagi Y, Akamatsu H, Otani H, Kodama M. Horizontal chromosome transfer, a mechanism for the evolution and differentiation of a plant-pathogenic fungus. Eukaryot Cell. 2009;8:1732-8 pubmed publisher
    The tomato pathotype of Alternaria alternata produces host-specific AAL toxin and causes Alternaria stem canker on tomato. A polyketide synthetase (PKS) gene, ALT1, which is involved in AAL toxin biosynthesis, resides on a 1...
  8. Pedras M, Minic Z, Sarma Mamillapalle V. Substrate specificity and inhibition of brassinin hydrolases, detoxifying enzymes from the plant pathogens Leptosphaeria maculans and Alternaria brassicicola. FEBS J. 2009;276:7412-28 pubmed publisher
    Blackleg (Leptosphaeria maculans and Leptosphaeria biglobosa) and black spot (Alternaria brassicicola) fungi are devastating plant pathogens known to detoxify the plant defence metabolite, brassinin...
  9. Joubert A, Simoneau P, Campion C, Bataille Simoneau N, Iacomi Vasilescu B, Poupard P, et al. Impact of the unfolded protein response on the pathogenicity of the necrotrophic fungus Alternaria brassicicola. Mol Microbiol. 2011;79:1305-24 pubmed publisher
    ..We investigated the importance of the UPR pathway in the pathogenicity of the plant necrotrophic fungus Alternaria brassicicola, which causes black spot disease on a wide range of Brassicaceae...
  10. Cheng D, Jia Y, Gao H, Zhang L, Zhang Z, Xue Z, et al. Characterization of the programmed cell death induced by metabolic products of Alternaria alternata in tobacco BY-2 cells. Physiol Plant. 2011;141:117-29 pubmed publisher
    b>Alternaria alternata has received considerable attention in current literature and most of the studies are focused on its pathogenic effects on plant chloroplasts, but little is known about the characteristics of programmed cell death (..
  11. Hu J, Chen C, Peever T, Dang H, Lawrence C, Mitchell T. Genomic characterization of the conditionally dispensable chromosome in Alternaria arborescens provides evidence for horizontal gene transfer. BMC Genomics. 2012;13:171 pubmed publisher
    Fungal plant pathogens cause serious agricultural losses worldwide. Alternaria arborescens is a major pathogen of tomato, with its virulence determined by the presence of a conditionally dispensable chromosome (CDC) carrying host-specific ..
  12. Qi L, Yan J, Li Y, Jiang H, Sun J, Chen Q, et al. Arabidopsis thaliana plants differentially modulate auxin biosynthesis and transport during defense responses to the necrotrophic pathogen Alternaria brassicicola. New Phytol. 2012;195:872-82 pubmed publisher
    ..aspects of the auxin pathway are generally more susceptible than wild-type plants to the necrotrophic pathogen Alternaria brassicicola. We show that A...
  13. Liu D, Liu Y, Qiu F, Gao Y, Zhang J. Biotransformation of oleanolic acid by Alternaria longipes and Penicillium adametzi. J Asian Nat Prod Res. 2011;13:160-7 pubmed publisher
    Microbial transformation of oleanolic acid (1) was carried out. Six transformed products (2-7) from 1 by Alternaria longipes and three transformed products (8-10) from 1 by Penicillium adametzi were isolated...
  14. Hedayati M, Arabzadehmoghadam A, Hajheydari Z. Specific IgE against Alternaria alternata in atopic dermatitis and asthma patients. Eur Rev Med Pharmacol Sci. 2009;13:187-91 pubmed
    b>Alternaria alternata (A. alternata) is one of the most common airborne fungi in outdoor and indoor environment. A. alternata has also considered as an aeroallergen...
  15. Linde C, Liles J, Thrall P. Expansion of genetic diversity in randomly mating founder populations of Alternaria brassicicola infecting Cakile maritima in Australia. Appl Environ Microbiol. 2010;76:1946-54 pubmed publisher
    ..This study used microsatellite markers in the interaction between Cakile maritima and the fungal pathogen Alternaria brassicicola to explore genetic expectations associated with such situations. The host, C...
  16. Jia C, Zhang L, Liu L, Wang J, Li C, Wang Q. Multiple phytohormone signalling pathways modulate susceptibility of tomato plants to Alternaria alternata f. sp. lycopersici. J Exp Bot. 2013;64:637-50 pubmed publisher
    ..crosstalk during the interaction between tomato (Solanum lycopersicum) plants and a necrotrophic fungal pathogen Alternaria alternata f. sp. lycopersici (AAL)...
  17. Twaroch T, Focke M, Fleischmann K, Balic N, Lupinek C, Blatt K, et al. Carrier-bound Alt a 1 peptides without allergenic activity for vaccination against Alternaria alternata allergy. Clin Exp Allergy. 2012;42:966-75 pubmed publisher
    The mould Alternaria alternata is a major elicitor of allergic asthma. Diagnosis and specific immunotherapy (SIT) of Alternaria allergy are often limited by the insufficient quality of natural mould extracts.
  18. Kulye M, Liu H, Zhang Y, Zeng H, Yang X, Qiu D. Hrip1, a novel protein elicitor from necrotrophic fungus, Alternaria tenuissima, elicits cell death, expression of defence-related genes and systemic acquired resistance in tobacco. Plant Cell Environ. 2012;35:2104-20 pubmed publisher
    ..and gene cloning of a novel hypersensitive response inducing protein secreted by necrotrophic fungus, Alternaria tenuissima, designated as hypersensitive response inducing protein 1 (Hrip1)...
  19. Mukherjee A, Carp M, Zuchman R, Ziv T, Horwitz B, Gepstein S. Proteomics of the response of Arabidopsis thaliana to infection with Alternaria brassicicola. J Proteomics. 2010;73:709-20 pubmed publisher
    ..We have studied the proteome of the model plant Arabidopsis thaliana infected with a necrotrophic fungal pathogen, Alternaria brassicicola. The Arabidopsis-A...
  20. Huang C, Pan J, Chen B, Yu M, Huang H, Zhu X, et al. Three bianthraquinone derivatives from the mangrove endophytic fungus Alternaria sp. ZJ9-6B from the South China Sea. Mar Drugs. 2011;9:832-43 pubmed publisher
    ..K (1), L (2) and M (3), along with six known compounds were obtained from extracts of the endophytic fungus Alternaria sp. ZJ9-6B, isolated from the mangrove Aegiceras corniculatum collected in the South China Sea...
  21. Denis O, Vincent M, Havaux X, De Prins S, Treutens G, Huygen K. Induction of the specific allergic immune response is independent of proteases from the fungus Alternaria alternata. Eur J Immunol. 2013;43:907-17 pubmed publisher
    We have analyzed the importance of proteases for the induction of allergic responses against the mold Alternaria alternata...
  22. Cho Y, Kim K, La Rota M, Scott D, Santopietro G, Callihan M, et al. Identification of novel virulence factors associated with signal transduction pathways in Alternaria brassicicola. Mol Microbiol. 2009;72:1316-33 pubmed publisher
    b>Alternaria brassicicola is an important, necrotrophic fungal pathogen that causes black spot disease on Brassicas...
  23. Müller M, Steier I, Köppen R, Siegel D, Proske M, Korn U, et al. Cocultivation of phytopathogenic Fusarium and Alternaria strains affects fungal growth and mycotoxin production. J Appl Microbiol. 2012;113:874-87 pubmed publisher
    A laboratory study was conducted to evaluate the influence of cocultivation of toxigenic Fusarium (F.) and Alternaria (A.) fungi with respect to growth and mycotoxin production.
  24. Johann S, Rosa L, Rosa C, Perez P, Cisalpino P, Zani C, et al. Antifungal activity of altenusin isolated from the endophytic fungus Alternaria sp. against the pathogenic fungus Paracoccidioides brasiliensis. Rev Iberoam Micol. 2012;29:205-9 pubmed publisher
    ..Altenusin is a biphenyl derivative isolated from different species of fungi, which presents several biological activities...
  25. Shi J, Zeng Q, Liu Y, Pan Z. Alternaria sp. MG1, a resveratrol-producing fungus: isolation, identification, and optimal cultivation conditions for resveratrol production. Appl Microbiol Biotechnol. 2012;95:369-79 pubmed publisher
    ..belonged to seven genera, Botryosphaeria, Penicillium, Cephalosporium, Aspergillus, Geotrichum, Mucor, and Alternaria. The resveratrol-producing capability decreased or was completely lost in most isolates after three rounds of ..
  26. Leino M, Loxham M, Blume C, Swindle E, Jayasekera N, Dennison P, et al. Barrier disrupting effects of alternaria alternata extract on bronchial epithelium from asthmatic donors. PLoS ONE. 2013;8:e71278 pubmed publisher
    Sensitization and exposure to the allergenic fungus Alternaria alternata has been associated with increased risk of asthma and asthma exacerbations...
  27. Robert Seilaniantz A, Maclean D, Jikumaru Y, Hill L, Yamaguchi S, Kamiya Y, et al. The microRNA miR393 re-directs secondary metabolite biosynthesis away from camalexin and towards glucosinolates. Plant J. 2011;67:218-31 pubmed publisher
    ..We propose that miR393 levels can fine-tune plant defences and prioritize resources...
  28. Tsuge T, Harimoto Y, Akimitsu K, Ohtani K, Kodama M, Akagi Y, et al. Host-selective toxins produced by the plant pathogenic fungus Alternaria alternata. FEMS Microbiol Rev. 2013;37:44-66 pubmed publisher
    ..There are now seven known diseases caused by Alternaria alternata in which HSTs are responsible for fungal pathogenesis...
  29. Stewart J, Thomas K, Lawrence C, Dang H, Pryor B, Timmer L, et al. Signatures of recombination in clonal lineages of the citrus brown spot pathogen, Alternaria alternata sensu lato. Phytopathology. 2013;103:741-9 pubmed publisher
    Most Alternaria spp. are considered asexual but recent molecular evolution analyses of Alternaria mating-type genes show that the mating locus is under strong purifying selection, indicating a possible role in sexual reproduction...
  30. Yildiz E, Ailani H, Hammersmith K, Eagle R, Rapuano C, Cohen E. Alternaria and paecilomyces keratitis associated with soft contact lens wear. Cornea. 2010;29:564-8 pubmed publisher
    ..To report a series of 5 patients with soft contact lens (SCL) related fungal keratitis caused by unusual organisms diagnosed at the Wills Eye Institute, Cornea Service in 2008...
  31. Lin C, Yang S, Chung K. The YAP1 homolog-mediated oxidative stress tolerance is crucial for pathogenicity of the necrotrophic fungus Alternaria alternata in citrus. Mol Plant Microbe Interact. 2009;22:942-52 pubmed publisher
    Citrus brown spot disease is caused by the necrotrophic fungus Alternaria alternata. Its pathogenic capability has been thought to depend exclusively on the production of host-selective ACT toxin...
  32. Phuwapraisirisan P, Rangsan J, Siripong P, Tip Pyang S. New antitumour fungal metabolites from Alternaria porri. Nat Prod Res. 2009;23:1063-71 pubmed publisher
    Chemical investigation of the onion pathogenic fungus Alternaria porri resulted in the isolation of two new phthalides named zinnimide (2) and deprenylzinnimide (8), along with a new bianthraquinone, alterporriol F (10)...
  33. Boitano S, Flynn A, Sherwood C, Schulz S, Hoffman J, Gruzinova I, et al. Alternaria alternata serine proteases induce lung inflammation and airway epithelial cell activation via PAR2. Am J Physiol Lung Cell Mol Physiol. 2011;300:L605-14 pubmed publisher
    ..b>Alternaria alternata is a strong asthmagen in semiarid regions. We examined the impact of proteases from A...
  34. Grinn Gofron A, Strzelczak A. Hourly predictive artificial neural network and multivariate regression tree models of Alternaria and Cladosporium spore concentrations in Szczecin (Poland). Int J Biometeorol. 2009;53:555-62 pubmed publisher
    ..Sampling was carried out with a Lanzoni 7-day-recording spore trap. The spores analysed belonged to the taxa Alternaria and Cladosporium...
  35. Alizadeh H, Leung D, Cole A. Conidiogenic effects of mannose-binding lectins isolated from cotyledons of red kidney bean (Phaseolus vulgaris) on Alternaria alternata. Phytochemistry. 2011;72:94-9 pubmed publisher
    Effect of proteinaceous extracts from red kidney bean cotyledons on mycelium of Alternaria alternata growing on potato dextrose agar (PDA) plates was investigated...
  36. Sinha R, Chattopadhyay S. Changes in the leaf proteome profile of Mentha arvensis in response to Alternaria alternata infection. J Proteomics. 2011;74:327-36 pubmed publisher
    ..study the changes in the leaf proteome profile of the plant Mentha arvensis infected with a necrotrophic fungus, Alternaria alternata...
  37. Zheng C, Shao C, Guo Z, Chen J, Deng D, Yang K, et al. Bioactive hydroanthraquinones and anthraquinone dimers from a soft coral-derived Alternaria sp. fungus. J Nat Prod. 2012;75:189-97 pubmed publisher
    ..12-16), along with seven known analogues (6-11 and 17), were isolated from the culture broth and the mycelia of Alternaria sp. ZJ-2008003, a fungus obtained from a Sarcophyton sp. soft coral collected from the South China Sea...
  38. Doherty T, Khorram N, Sugimoto K, Sheppard D, Rosenthal P, Cho J, et al. Alternaria induces STAT6-dependent acute airway eosinophilia and epithelial FIZZ1 expression that promotes airway fibrosis and epithelial thickness. J Immunol. 2012;188:2622-9 pubmed publisher
    The fungal allergen, Alternaria, is specifically associated with severe asthma, including life-threatening exacerbations...
  39. Murai H, Qi H, Choudhury B, Wild J, Dharajiya N, Vaidya S, et al. Alternaria-induced release of IL-18 from damaged airway epithelial cells: an NF-?B dependent mechanism of Th2 differentiation?. PLoS ONE. 2012;7:e30280 pubmed publisher
    A series of epidemiologic studies have identified the fungus Alternaria as a major risk factor for asthma. The airway epithelium plays a critical role in the pathogenesis of allergic asthma...
  40. Zhang X, Wang C, Zhang Y, Sun Y, Mou Z. The Arabidopsis mediator complex subunit16 positively regulates salicylate-mediated systemic acquired resistance and jasmonate/ethylene-induced defense pathways. Plant Cell. 2012;24:4294-309 pubmed publisher
    ..ET)-responsive genes and compromised resistance to the necrotrophic fungal pathogens Botrytis cinerea and Alternaria brassicicola...
  41. Imazaki A, Tanaka A, Harimoto Y, Yamamoto M, Akimitsu K, Park P, et al. Contribution of peroxisomes to secondary metabolism and pathogenicity in the fungal plant pathogen Alternaria alternata. Eukaryot Cell. 2010;9:682-94 pubmed publisher
    The filamentous fungus Alternaria alternata includes seven pathogenic variants (pathotypes) which produce different host-selective toxins and cause diseases on different plants...
  42. Graf E, Schmidt Heydt M, Geisen R. HOG MAP kinase regulation of alternariol biosynthesis in Alternaria alternata is important for substrate colonization. Int J Food Microbiol. 2012;157:353-9 pubmed publisher
    Strains of the genus Alternaria are ubiquitously present and frequently found on fruits, vegetables and cereals. One of the most commonly found species from this genus is A...
  43. Kannan P, Pandey D, Gupta A, Punetha H, Taj G, Kumar A. Expression analysis of MAP2K9 and MAPK6 during pathogenesis of Alternaria blight in Arabidopsis thaliana ecotype Columbia. Mol Biol Rep. 2012;39:4439-44 pubmed publisher
    ..was used as a host in order to investigate the involvement of MAP kinase machinery in the pathogenesis of Alternaria blight...
  44. Dey P, Banerjee J, Maiti M. Comparative lipid profiling of two endophytic fungal isolates--Colletotrichum sp. and Alternaria sp. having potential utilities as biodiesel feedstock. Bioresour Technol. 2011;102:5815-23 pubmed publisher
    Lipid accumulation abilities of two endophytic fungal isolates - Colletotrichum sp. and Alternaria sp. grown under optimum and nutrient-stress conditions were investigated and compared...
  45. Wolf J, O Neill N, Rogers C, Muilenberg M, Ziska L. Elevated atmospheric carbon dioxide concentrations amplify Alternaria alternata sporulation and total antigen production. Environ Health Perspect. 2010;118:1223-8 pubmed publisher
    ..Although the effect of elevated carbon dioxide (CO2) concentration on pollen production has been established in some plant species, impacts on fungal sporulation and antigen production have not been elucidated...
  46. Somma S, Pose G, Pardo A, Mulè G, Pinto V, Moretti A, et al. AFLP variability, toxin production, and pathogenicity of Alternaria species from Argentinean tomato fruits and puree. Int J Food Microbiol. 2011;145:414-9 pubmed publisher
    Large amounts of tomato fruits and derived products are produced in Argentina and may be contaminated by Alternaria toxins...
  47. Kim K, Willger S, Park S, Puttikamonkul S, Grahl N, Cho Y, et al. TmpL, a transmembrane protein required for intracellular redox homeostasis and virulence in a plant and an animal fungal pathogen. PLoS Pathog. 2009;5:e1000653 pubmed publisher
    ..ROS levels and tolerance to external ROS, and is required for infection of plants by the necrotroph Alternaria brassicicola and for infection of mammals by the human pathogen Aspergillus fumigatus...
  48. Kouzaki H, Iijima K, Kobayashi T, O Grady S, Kita H. The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses. J Immunol. 2011;186:4375-87 pubmed publisher
    ..Airway exposure of naive mice to a common environmental aeroallergen, the fungus Alternaria alternata, induces rapid release of IL-33 into the airway lumen, followed by innate Th2-type responses...
  49. Stewart J, Kawabe M, Abdo Z, Arie T, Peever T. Contrasting codon usage patterns and purifying selection at the mating locus in putatively asexual alternaria fungal species. PLoS ONE. 2011;6:e20083 pubmed publisher
    ..A large number of phytopathogenic fungi including Alternaria spp. are considered asexual, yet still carry expressed MAT1 genes...
  50. Oviedo M, Ramirez M, Barros G, Chulze S. Influence of water activity and temperature on growth and mycotoxin production by Alternaria alternata on irradiated soya beans. Int J Food Microbiol. 2011;149:127-32 pubmed publisher
    ..and their interactions on growth and alternariol (AOH) and alternariol monomethyl ether (AME) production by Alternaria alternata on irradiated soya beans. Maximum growth rates were obtained at 0.980 a(w) and 25°C...
  51. Matsuwaki Y, Wada K, White T, Benson L, Charlesworth M, Checkel J, et al. Recognition of fungal protease activities induces cellular activation and eosinophil-derived neurotoxin release in human eosinophils. J Immunol. 2009;183:6708-16 pubmed publisher
    ..Associations between exposure to an environmental fungus, such as Alternaria, and asthma have been recognized clinically...
  52. Srivastava A, Ohm R, Oxiles L, Brooks F, Lawrence C, Grigoriev I, et al. A zinc-finger-family transcription factor, AbVf19, is required for the induction of a gene subset important for virulence in Alternaria brassicicola. Mol Plant Microbe Interact. 2012;25:443-52 pubmed publisher
    b>Alternaria brassicicola is a successful saprophyte and necrotrophic plant pathogen with a broad host range within the family Brassicaceae. It produces secondary metabolites that marginally affect virulence...
  53. Kjer J, Wray V, Edrada Ebel R, Ebel R, Pretsch A, Lin W, et al. Xanalteric acids I and II and related phenolic compounds from an endophytic Alternaria sp. isolated from the mangrove plant Sonneratia alba. J Nat Prod. 2009;72:2053-7 pubmed publisher
    ..acids I (1) and II (2), and 11 known secondary metabolites were obtained from extracts of the endophytic fungus Alternaria sp., isolated from the mangrove plant Sonneratia alba collected in China...
  54. Li D, Zhang Y, Ji H, Wu X, Pei Y, Bai J. Tricycloalternarene derivatives from endophytic fungus Alternaria tenuissima SY-P-07. Nat Prod Res. 2013;27:1877-81 pubmed publisher
    A new tricycloalternarene, TCA 11a (1), was isolated from the culture broth of an endophytic fungus, Alternaria tenuissima SY-P-07, along with four known structurally related compounds 2-5...
  55. Luo Y, Yang J, Zhu M, Liu C, Li H, Lu Z, et al. The group III two-component histidine kinase AlHK1 is involved in fungicides resistance, osmosensitivity, spore production and impacts negatively pathogenicity in Alternaria longipes. Curr Microbiol. 2012;64:449-56 pubmed publisher
    ..disruption of the gene encoding group III histidine kinase, AlHK1, in the economically important plant pathogen Alternaria longipes. The AlHK1 gene disruption had pleiotropic effects on this fungus...
  56. Chen L, Lin C, Chung K. A nonribosomal peptide synthetase mediates siderophore production and virulence in the citrus fungal pathogen Alternaria alternata. Mol Plant Pathol. 2013;14:497-505 pubmed publisher
    b>Alternaria species produce and excrete dimethyl coprogen siderophores to acquire iron...
  57. Kim M, Sohn J, Ahn J, Oh H. Alternaramide, a cyclic depsipeptide from the marine-derived fungus Alternaria sp. SF-5016. J Nat Prod. 2009;72:2065-8 pubmed publisher
    ..1), a cyclic pentadepsipeptide, has been isolated from an EtOAc extract of the marine-derived fungus Alternaria sp. SF-5016 by various chromatographic methods...
  58. Gao S, Li X, Wang B. Perylene derivatives produced by Alternaria alternata, an endophytic fungus isolated from Laurencia species. Nat Prod Commun. 2009;4:1477-80 pubmed
    ..2), along with two known compounds stemphyperylenol (3) and altertoxin I (4) were isolated from Alternaria alternata, a marine endophytic fungus derived from an unidentified algal species of the genus Laurencia...
  59. Oviedo M, Ramirez M, Barros G, Chulze S. Impact of water activity and temperature on growth and alternariol and alternariol monomethyl ether production of Alternaria alternata isolated from soybean. J Food Prot. 2010;73:336-43 pubmed
    ..Two Alternaria alternata strains isolated from soybeans in Argentina were grown on 2% soybean extract agar...
  60. Wight W, Kim K, Lawrence C, Walton J. Biosynthesis and role in virulence of the histone deacetylase inhibitor depudecin from Alternaria brassicicola. Mol Plant Microbe Interact. 2009;22:1258-67 pubmed publisher
    Depudecin, an eleven-carbon linear polyketide made by the pathogenic fungus Alternaria brassicicola, is an inhibitor of histone deacetylase (HDAC)...
  61. Tiessen C, Fehr M, Schwarz C, Baechler S, Domnanich K, Böttler U, et al. Modulation of the cellular redox status by the Alternaria toxins alternariol and alternariol monomethyl ether. Toxicol Lett. 2013;216:23-30 pubmed publisher
    ..In summary, the mycotoxins AOH and AME were found to modulate the redox balance of HT29 cells but without apparent negative effect on DNA integrity...
  62. Joubert A, Calmes B, Berruyer R, Pihet M, Bouchara J, Simoneau P, et al. Laser nephelometry applied in an automated microplate system to study filamentous fungus growth. Biotechniques. 2010;48:399-404 pubmed publisher
    ..This microplate reader technique is applicable for the evaluation of antifungal activity and for large-scale phenotypic profiling...
  63. Saha D, Fetzner R, Burkhardt B, Podlech J, Metzler M, Dang H, et al. Identification of a polyketide synthase required for alternariol (AOH) and alternariol-9-methyl ether (AME) formation in Alternaria alternata. PLoS ONE. 2012;7:e40564 pubmed publisher
    b>Alternaria alternata produces more than 60 secondary metabolites, among which alternariol (AOH) and alternariol-9-methyl ether (AME) are important mycotoxins...
  64. Pose G, Patriarca A, Kyanko V, Pardo A, Fernandez Pinto V. Water activity and temperature effects on mycotoxin production by Alternaria alternata on a synthetic tomato medium. Int J Food Microbiol. 2010;142:348-53 pubmed publisher
    b>Alternaria spp. have been reported to be the most frequent fungal species invading tomatoes. Certain species, in particular the most common one, A...
  65. Fleck S, Burkhardt B, Pfeiffer E, Metzler M. Alternaria toxins: Altertoxin II is a much stronger mutagen and DNA strand breaking mycotoxin than alternariol and its methyl ether in cultured mammalian cells. Toxicol Lett. 2012;214:27-32 pubmed publisher
    Altertoxin II (ATX II) is one of the several mycotoxins produced by Alternaria fungi...
  66. Chruszcz M, Chapman M, Osinski T, Solberg R, Demas M, Porebski P, et al. Alternaria alternata allergen Alt a 1: a unique ?-barrel protein dimer found exclusively in fungi. J Allergy Clin Immunol. 2012;130:241-7.e9 pubmed publisher
    b>Alternaria species is one of the most common molds associated with allergic diseases, and 80% of Alternaria species-sensitive patients produce IgE antibodies to a major protein allergen, Alt a 1...
  67. Lawrence D, Gannibal P, Peever T, Pryor B. The sections of Alternaria: formalizing species-group concepts. Mycologia. 2013;105:530-46 pubmed publisher
    The systematics of Alternaria and allied genera traditionally has been based on the characteristics of conidia and the sporulation apparatus...
  68. Siegel D, Feist M, Proske M, Koch M, Nehls I. Degradation of the Alternaria mycotoxins alternariol, alternariol monomethyl ether, and altenuene upon bread baking. J Agric Food Chem. 2010;58:9622-30 pubmed publisher
    The stability of the Alternaria mycotoxins alternariol, alternariol monomethyl ether, and altenuene upon bread baking was investigated by model experiments using a spiked wholemeal wheat flour matrix...
  69. Matsuwaki Y, Wada K, White T, Moriyama H, Kita H. Alternaria fungus induces the production of GM-CSF, interleukin-6 and interleukin-8 and calcium signaling in human airway epithelium through protease-activated receptor 2. Int Arch Allergy Immunol. 2012;158 Suppl 1:19-29 pubmed publisher
    ..We previously reported that aspartate protease from Alternaria induces the activation and degranulation of human eosinophils that are mediated through protease-activated ..
  70. Greco M, Patriarca A, Terminiello L, Fernandez Pinto V, Pose G. Toxigenic Alternaria species from Argentinean blueberries. Int J Food Microbiol. 2012;154:187-91 pubmed publisher
    ..The genus Alternaria was the main component of the blueberry mycobiota (95%); minor proportions of Phoma spp...
  71. Yang S, Chung K. The NADPH oxidase-mediated production of hydrogen peroxide (H(2)O(2)) and resistance to oxidative stress in the necrotrophic pathogen Alternaria alternata of citrus. Mol Plant Pathol. 2012;13:900-14 pubmed publisher
    ..We cloned and characterized an AaNoxA gene of the necrotrophic fungus Alternaria alternata, which encodes a polypeptide analogous to mammalian gp91(phox) and fungal Noxs implicated in the ..