encephalitozoon cuniculi

Summary

Summary: A species of parasitic FUNGI. This intracellular parasite is found in the BRAIN; HEART; and KIDNEYS of several MAMMALS. Transmission is probably by ingestion of the spores (SPORES, FUNGAL).

Top Publications

  1. Brosson D, Kuhn L, Delbac F, Garin J, P Vivarès C, Texier C. Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages. Proteomics. 2006;6:3625-35 pubmed
    The microsporidian Encephalitozoon cuniculi is a unicellular obligate intracellular parasite considered as an emerging opportunistic human pathogen...
  2. Wagnerová P, Sak B, Kvetonova D, Buňatová Z, Civišová H, Maršálek M, et al. Enterocytozoon bieneusi and Encephalitozoon cuniculi in horses kept under different management systems in the Czech Republic. Vet Parasitol. 2012;190:573-7 pubmed publisher
    ..Microsporidia were found on 16 farms and the overall prevalence of Enterocytozoon bieneusi and Encephalitozoon cuniculi was 17.3% (66/377) and 6.9% (26/377), respectively. The prevalence of E...
  3. Ditrich O, Chrdle A, Sak B, Chmelik V, Kubále J, Dykova I, et al. Encephalitozoon cuniculi genotype I as a causative agent of brain abscess in an immunocompetent patient. J Clin Microbiol. 2011;49:2769-71 pubmed publisher
    A brain abscess caused by Encephalitozoon cuniculi genotype I together with Streptococcus intermedius occurred in a patient without major immunocompromise and with diabetes. The distinguishing clinical signs were hemiparesis and epilepsy...
  4. Orenstein J, Russo P, Didier E, Bowers C, Bunin N, Teachey D. Fatal pulmonary microsporidiosis due to encephalitozoon cuniculi following allogeneic bone marrow transplantation for acute myelogenous leukemia. Ultrastruct Pathol. 2005;29:269-76 pubmed
    ..confirmed the diagnosis and furthermore revealed it to be the dog strain of the microsporidia species Encephalitozoon cuniculi. Although to date rarely diagnosed, microsporidial infection should also be considered in the ..
  5. Mo L, Drancourt M. Monoclonal antibodies for specific detection of Encephalitozoon cuniculi. Clin Diagn Lab Immunol. 2004;11:1060-3 pubmed
    Seven species-specific monoclonal antibodies (MAbs) were produced against Encephalitozoon cuniculi and characterized...
  6. Rimour S, Hill D, Militon C, Peyret P. GoArrays: highly dynamic and efficient microarray probe design. Bioinformatics. 2005;21:1094-103 pubmed
    ..Indeed, our biological model is a human obligate parasite, the microsporidia Encephalitozoon cuniculi. Targets that are extracted from biological samples are composed of a mixture of pathogen transcripts and ..
  7. Wei S, Daniel B, Brumlik M, Burow M, Zou W, Khan I, et al. Drugs designed to inhibit human p38 mitogen-activated protein kinase activation treat Toxoplasma gondii and Encephalitozoon cuniculi infection. Antimicrob Agents Chemother. 2007;51:4324-8 pubmed
    ..gondii inoculum. A MAPK inhibitor also treated mice infected with the Microsporidium parasite Encephalitozoon cuniculi, suggesting that MAPK inhibitors represent a novel class of agents that may have a broad spectrum of ..
  8. Tee K, Kao J, Chiu H, Chang M, Wang J, Tung K, et al. Serological survey for antibodies to Encephalitozoon cuniculi in rabbits in Taiwan. Vet Parasitol. 2011;183:68-71 pubmed publisher
    b>Encephalitozoon cuniculi (E. cuniculi) is a microsporidian parasite commonly found in rabbits that can infect humans, causing encephalitozoonosis...
  9. Urch J, Hurtado Guerrero R, Brosson D, Liu Z, Eijsink V, Texier C, et al. Structural and functional characterization of a putative polysaccharide deacetylase of the human parasite Encephalitozoon cuniculi. Protein Sci. 2009;18:1197-209 pubmed publisher
    The microsporidian Encephalitozoon cuniculi is an intracellular eukaryotic parasite considered to be an emerging opportunistic human pathogen...

More Information

Publications71

  1. Khan I, Moretto M. Role of gamma interferon in cellular immune response against murine Encephalitozoon cuniculi infection. Infect Immun. 1999;67:1887-93 pubmed
    ..Because it is able to grow in vitro, Encephalitozoon cuniculi is currently the best-studied microsporidian. T cells mediate protective immunity against this parasite...
  2. Ashmawy K, Abuakkada S, Awad A. Seroprevalence of antibodies to Encephalitozoon cuniculi and Toxoplasma gondii in farmed domestic rabbits in Egypt. Zoonoses Public Health. 2011;58:357-64 pubmed publisher
    ..in Northern Egypt (Behera, Alexandria and Khafr El-Sheikh) were submitted to serological screening for Encephalitozoon cuniculi using an enzyme-linked immunosorbent assay and for Toxoplasma gondii using an indirect hemagglutination ..
  3. Grisdale C, Fast N. Patterns of 5' untranslated region length distribution in Encephalitozoon cuniculi: implications for gene regulation and potential links between transcription and splicing. J Eukaryot Microbiol. 2011;58:68-74 pubmed publisher
    b>Encephalitozoon cuniculi, a eukaryotic intracellular parasite belonging to the group Microsporidia, has a highly reduced and compacted genome...
  4. Rönnebäumer K, Gross U, Bohne W. The nascent parasitophorous vacuole membrane of Encephalitozoon cuniculi is formed by host cell lipids and contains pores which allow nutrient uptake. Eukaryot Cell. 2008;7:1001-8 pubmed publisher
    ..We investigated the origin of the nascent Encephalitozoon cuniculi PV membrane with the aid of fluorescent lipid probes...
  5. Grisdale C, Bowers L, Didier E, Fast N. Transcriptome analysis of the parasite Encephalitozoon cuniculi: an in-depth examination of pre-mRNA splicing in a reduced eukaryote. BMC Genomics. 2013;14:207 pubmed publisher
    The microsporidian Encephalitozoon cuniculi possesses one of the most reduced and compacted eukaryotic genomes...
  6. Franzen C, Muller A, Hartmann P, Salzberger B. Cell invasion and intracellular fate of Encephalitozoon cuniculi (Microsporidia). Parasitology. 2005;130:285-92 pubmed
    ..have initiated a study to investigate the invasive process and intracellular fate of the microsporidium Encephalitozoon cuniculi. Here we show that relatively few cells were infected through the traditional penetration of the polar ..
  7. Fasshauer V, Gross U, Bohne W. The parasitophorous vacuole membrane of Encephalitozoon cuniculi lacks host cell membrane proteins immediately after invasion. Eukaryot Cell. 2005;4:221-4 pubmed
    ..The nonfusiogenic characteristic of the PV appears to be acquired as early as 1 min postinfection and is not reversed by drug treatment with albendazole or fumagillin...
  8. Salat J, Horka H, Sak B, Kopecky J. Pure CD4+ T lymphocytes fail to protect perorally infected SCID mice from lethal microsporidiosis caused by Encephalitozoon cuniculi. Parasitol Res. 2006;99:682-6 pubmed
    ..p.) or perorally (p.o.) acquired Encephalitozoon cuniculi (Levaditi et al...
  9. Jordan C, Zajac A, Snowden K, Lindsay D. Direct agglutination test for Encephalitozoon cuniculi. Vet Parasitol. 2006;135:235-40 pubmed
    b>Encephalitozoon cuniculi is a small protozoan parasite in the phylum Microspora. It has been shown to naturally infect several host species, including humans...
  10. Okewole E. Seroprevalence of antibodies to Encephalitozoon cuniculi in domestic rabbits in Nigeria. Onderstepoort J Vet Res. 2008;75:33-8 pubmed
    ..Southeast (SE), Southwest (SW) and Northcentral (NC), were evaluated for the presence of antibodies to Encephalitozoon cuniculi by the indirect immunofluorescent antibodies test. A titre of 10 or more was taken as positive...
  11. Reetz J, Nockler K, Reckinger S, Vargas M, Weiske W, Broglia A. Identification of Encephalitozoon cuniculi genotype III and two novel genotypes of Enterocytozoon bieneusi in swine. Parasitol Int. 2009;58:285-92 pubmed publisher
    ..and the immunohistochemistry (the Avidin-Biotin-Peroxidase-Complex technique with a polyclonal anti-Encephalitozoon cuniculi-serum and monoclonal antibodies against Encephalitozoon intestinalis and Enterocytozoon bieneusi) was ..
  12. Cornman R, Chen Y, Schatz M, Street C, Zhao Y, Desany B, et al. Genomic analyses of the microsporidian Nosema ceranae, an emergent pathogen of honey bees. PLoS Pathog. 2009;5:e1000466 pubmed publisher
    ..protein-coding sequences, we conservatively estimate that 1,366 have homologs in the microsporidian Encephalitozoon cuniculi, the most closely related published genome sequence...
  13. Moretto M, Durell B, Schwartzman J, Khan I. Gamma delta T cell-deficient mice have a down-regulated CD8+ T cell immune response against Encephalitozoon cuniculi infection. J Immunol. 2001;166:7389-97 pubmed
    ..In the present study, an early increase of gamma(delta) T cells during murine infection with Encephalitozoon cuniculi, an intracellular parasite, was observed. The role of gamma(delta) T cells against E...
  14. del Aguila C, Moura H, Fenoy S, Navajas R, Lopez Velez R, Li L, et al. In vitro culture, ultrastructure, antigenic, and molecular characterization of Encephalitozoon cuniculi isolated from urine and sputum samples from a Spanish patient with AIDS. J Clin Microbiol. 2001;39:1105-8 pubmed
    ..We identified them as Encephalitozoon cuniculi, type strain III (the dog genotype), based on ultrastructure, antigenic characteristics, PCR, and the ..
  15. Weiss L, Cali A, Levee E, Laplace D, Tanowitz H, Simon D, et al. Diagnosis of Encephalitozoon cuniculi infection by western blot and the use of cross-reactive antigens for the possible detection of microsporidiosis in humans. Am J Trop Med Hyg. 1992;47:456-62 pubmed
    Microsporidia are very primitive, eukaryotic, obligate, intracellular, protozoan parasites. Encephalitozoon cuniculi, a microsporidian originally described from a rabbit infection, has been described in humans as well as in many species ..
  16. Khan I, Schwartzman J, Kasper L, Moretto M. CD8+ CTLs are essential for protective immunity against Encephalitozoon cuniculi infection. J Immunol. 1999;162:6086-91 pubmed
    b>Encephalitozoon cuniculi is a protozoan parasite that has been implicated recently as a cause of opportunistic infection in immunocompromised individuals. Protective immunity in the normal host is T cell-dependent...
  17. Santaniello A, Dipineto L, Rinaldi L, Menna L, Cringoli G, Fioretti A. Serological survey of Encephalitozoon cuniculi in farm rabbits in Italy. Res Vet Sci. 2009;87:67-9 pubmed publisher
    Rabbit sera (n=1600) from 40 commercial farms were submitted to a serological screening for Encephalitozoon cuniculi by an enzyme-linked immunosorbent assay (ELISA) and a carbon immunoassay (CIA test)...
  18. Peyretaillade E, Gonçalves O, Terrat S, Dugat Bony E, Wincker P, Cornman R, et al. Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation. BMC Genomics. 2009;10:607 pubmed publisher
    ..The extremely small (2.9 Mbp) and highly compact (approximately 1 gene/kb) genome of the human parasite Encephalitozoon cuniculi has been fully sequenced...
  19. Gigley J, Khan I. Plasmacytoid DC from aged mice down-regulate CD8 T cell responses by inhibiting cDC maturation after Encephalitozoon cuniculi infection. PLoS ONE. 2011;6:e20838 pubmed publisher
    ..studies report age related declines in innate immune responses to opportunistic pathogens including Encephalitozoon cuniculi. We previously demonstrated that conventional dendritic cells (cDC) from 9-month-old animals exhibit sub-..
  20. Pombert J, Selman M, Burki F, Bardell F, Farinelli L, Solter L, et al. Gain and loss of multiple functionally related, horizontally transferred genes in the reduced genomes of two microsporidian parasites. Proc Natl Acad Sci U S A. 2012;109:12638-43 pubmed publisher
    ..Complete sequences from Encephalitozoon intestinalis (2.3 Mbp) and Encephalitozoon cuniculi (2...
  21. Zanet S, Palese V, Trisciuoglio A, Cantón Alonso C, Ferroglio E. Encephalitozoon cuniculi, Toxoplasma gondii and Neospora caninum infection in invasive Eastern Cottontail Rabbits Sylvilagus floridanus in Northwestern Italy. Vet Parasitol. 2013;197:682-4 pubmed publisher
    ..floridanus were examined by PCR for Encephalitozoon cuniculi, Toxoplasma gondii and Neospora caninum. DNA of E. cuniculi was found with a prevalence of 9...
  22. Green L, Didier P, Didier E. Fractionation of sporogonial stages of the microsporidian Encephalitozoon cuniculi by Percoll gradients. J Eukaryot Microbiol. 1999;46:434-8 pubmed
    ..b>Encephalitozoon cuniculi has been identified in humans with AIDS and infects a wide range of mammalian hosts...
  23. Katinka M, Duprat S, Cornillot E, Metenier G, Thomarat F, Prensier G, et al. Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi. Nature. 2001;414:450-3 pubmed
    ..Here we report the DNA sequences of the 11 chromosomes of the approximately 2.9-megabase (Mb) genome of Encephalitozoon cuniculi (1,997 potential protein-coding genes)...
  24. Brosson D, Kuhn L, Prensier G, Vivares C, Texier C. The putative chitin deacetylase of Encephalitozoon cuniculi: a surface protein implicated in microsporidian spore-wall formation. FEMS Microbiol Lett. 2005;247:81-90 pubmed
    ..In this study on the human pathogen Encephalitozoon cuniculi, we identify by mass spectrometry the target of polyclonal antibodies previously raised against a 33-kDa ..
  25. Braunfuchsová P, Salat J, Kopecky J. CD8+ T lymphocytes protect SCID mice against Encephalitozoon cuniculi infection. Int J Parasitol. 2001;31:681-6 pubmed
    ..The role of two main T cell subsets in anti-microsporidial immunity has been studied using an Encephalitozoon cuniculi-severe combined immunodeficient (SCID) mouse model...
  26. Burglin T. The homeobox genes of Encephalitozoon cuniculi (Microsporidia) reveal a putative mating-type locus. Dev Genes Evol. 2003;213:50-2 pubmed
    Homeobox genes have been found in animals, fungi, and plants. Recently, the complete genomic sequence of Encephalitozoon cuniculi has become available and it was shown that this Microsporida species is related to fungi...
  27. Peuvel I, Peyret P, Metenier G, Vivares C, Delbac F. The microsporidian polar tube: evidence for a third polar tube protein (PTP3) in Encephalitozoon cuniculi. Mol Biochem Parasitol. 2002;122:69-80 pubmed
    ..A large multimeric complex was formed and shown to contain PTP1, PTP2 and PTP3 with a few other proteins. PTP3 is hypothesized to play a role in the control of the polar tube extrusion as part of a specific response to ionic stimuli...
  28. Bouzahzah B, Weiss L. Glycosylation of the major polar tube protein of Encephalitozoon cuniculi. Parasitol Res. 2010;107:761-4 pubmed publisher
    ..The observed post-translational mannosylation of PTP1 may be involved in the functional properties of the polar tube, including its adherence to host cells during penetration...
  29. Igarashi M, Oohashi E, Dautu G, Ueno A, Kariya T, Furuya K. High seroprevalence of Encephalitozoon cuniculi in pet rabbits in Japan. J Vet Med Sci. 2008;70:1301-4 pubmed
    Infection with Encephalitozoon cuniculi in rabbits frequently exists as a chronic, latent infection, and only a percentage of infected animals develop clinical disease. This study presents a seroepidemiological study of E...
  30. Fuglsang A. A cytosine-rich region upstream of start codons serving as a signal for initiation of translation in Encephalitozoon cuniculi?. Mol Biochem Parasitol. 2005;140:69-73 pubmed
    b>Encephalitozoon cuniculi, an intracellular eukaryote frequently infecting immunodeficient humans, displays pronounced compaction in its genes...
  31. Rönnebäumer K, Wagener J, Gross U, Bohne W. Identification of novel developmentally regulated genes in Encephalitozoon cuniculi: an endochitinase, a chitin-synthase, and two subtilisin-like proteases are induced during meront-to-sporont differentiation. J Eukaryot Microbiol. 2006;53 Suppl 1:S74-6 pubmed
  32. Gill E, Fast N. Stripped-down DNA repair in a highly reduced parasite. BMC Mol Biol. 2007;8:24 pubmed
    b>Encephalitozoon cuniculi is a member of a distinctive group of single-celled parasitic eukaryotes called microsporidia, which are closely related to fungi. Some of these organisms, including E...
  33. Hausmann S, Zheng S, Fabrega C, Schneller S, Lima C, Shuman S. Encephalitozoon cuniculi mRNA cap (guanine N-7) methyltransferase: methyl acceptor specificity, inhibition BY S-adenosylmethionine analogs, and structure-guided mutational analysis. J Biol Chem. 2005;280:20404-12 pubmed publisher
    The Encephalitozoon cuniculi mRNA cap (guanine N-7) methyltransferase Ecm1 has been characterized structurally but not biochemically...
  34. Khan I, Moretto M, Weiss L. Immune response to Encephalitozoon cuniculi infection. Microbes Infect. 2001;3:401-5 pubmed
    ..Very little is known about the host immune response generated against these infectious agents. Encephalitozoon cuniculi is the best studied microsporidian and the protective immune response against this parasite is mediated ..
  35. Chavant P, Taupin V, El Alaoui H, Wawrzyniak I, Chambon C, Prensier G, et al. Proteolytic activity in Encephalitozoon cuniculi sporogonial stages: predominance of metallopeptidases including an aminopeptidase-P-like enzyme. Int J Parasitol. 2005;35:1425-33 pubmed
    A fraction enriched in spore precursor cells (sporoblasts) of the microsporidian Encephalitozoon cuniculi, an intracellular parasite of mammals, was obtained by Percoll gradient centrifugation...
  36. Bohne W, Böttcher K, Gross U. The parasitophorous vacuole of Encephalitozoon cuniculi: biogenesis and characteristics of the host cell-pathogen interface. Int J Med Microbiol. 2011;301:395-9 pubmed publisher
    ..The model microsporidium Encephalitozoon cuniculi is a paradigm of a fungus with an extreme host cell dependency...
  37. Keeble E, Shaw D. Seroprevalence of antibodies to Encephalitozoon cuniculi in domestic rabbits in the United Kingdom. Vet Rec. 2006;158:539-44 pubmed
    Serum samples from 97 clinically healthy domestic rabbits were tested for antibodies to Encephalitozoon cuniculi by an indirect elisa technique. Fifty (52 per cent) of them were seropositive...
  38. Didier E, Bowers L, Martin A, Kuroda M, Khan I, Didier P. Reactive nitrogen and oxygen species, and iron sequestration contribute to macrophage-mediated control of Encephalitozoon cuniculi (Phylum Microsporidia) infection in vitro and in vivo. Microbes Infect. 2010;12:1244-51 pubmed publisher
    b>Encephalitozoon cuniculi (Phylum Microsporidia) infects a wide range of mammals, and replicates within resting macrophages. Activated macrophages, conversely, inhibit replication and destroy intracellular organisms...
  39. Peyretaillade E, Peyret P, Metenier G, Vivares C, Prensier G. The identification of rRNA maturation sites in the microsporidian Encephalitozoon cuniculi argues against the full excision of presumed ITS1 sequence. J Eukaryot Microbiol. 2001;Suppl:60S-62S pubmed
    In Encephalitozoon cuniculi like in other microsporidia, the primary transcript for SSU and LSU rRNAs includes only one internal transcribed spacer (ITS1) which separates SSU rRNA from the 5.8S region associated with LSU rRNA...
  40. Bouzahzah B, Nagajyothi F, Ghosh K, Takvorian P, Cali A, Tanowitz H, et al. Interactions of Encephalitozoon cuniculi polar tube proteins. Infect Immun. 2010;78:2745-53 pubmed publisher
    ..This study was undertaken to examine the protein interactions of the Encephalitozoon cuniculi polar tube proteins (EcPTPs)...
  41. Kotková M, Sak B, Kvetonova D, Kvac M. Latent microsporidiosis caused by Encephalitozoon cuniculi in immunocompetent hosts: a murine model demonstrating the ineffectiveness of the immune system and treatment with albendazole. PLoS ONE. 2013;8:e60941 pubmed publisher
    ..However, these pathogens are more frequently reported as latent infections in immunocompetent individuals and raises questions about the potential risk of reactivation following induced immunosuppression...
  42. Anete Lallo M, Porta Miche Hirschfeld M. Encephalitozoonosis in pharmacologically immunosuppressed mice. Exp Parasitol. 2012;131:339-43 pubmed publisher
    b>Encephalitozoon cuniculi is a parasite that has been identified as a cause of opportunistic infections in immunocompromised individuals. This study was performed to evaluate E. cuniculi infection in pharmacologically immunosuppressed mice...
  43. Didier E, Vossbrinck C, Baker M, Rogers L, Bertucci D, Shadduck J. Identification and characterization of three Encephalitozoon cuniculi strains. Parasitology. 1995;111 ( Pt 4):411-21 pubmed
    ..b>Encephalitozoon cuniculi is probably the most studied mammalian microsporidian that infects insects and mammals, including man...
  44. Bohne W, Ferguson D, Kohler K, Gross U. Developmental expression of a tandemly repeated, glycine- and serine-rich spore wall protein in the microsporidian pathogen Encephalitozoon cuniculi. Infect Immun. 2000;68:2268-75 pubmed
    ..A 51-kDa outer spore wall protein was identified in Encephalitozoon cuniculi with the aid of a monoclonal antibody, and the corresponding gene, SWP1, was cloned by immunoscreening of ..
  45. Peuvel Fanget I, Polonais V, Brosson D, Texier C, Kuhn L, Peyret P, et al. EnP1 and EnP2, two proteins associated with the Encephalitozoon cuniculi endospore, the chitin-rich inner layer of the microsporidian spore wall. Int J Parasitol. 2006;36:309-18 pubmed
    ..So far, only a chitin deacetylase-like protein has been shown to localize to the Encephalitozoon cuniculi endospore and either one or two proteins have been clearly assigned to the exospore in two ..
  46. Jelínek J, Salat J, Sak B, Kopecky J. Effects of interferon gamma and specific polyclonal antibody on the infection of murine peritoneal macrophages and murine macrophage cell line PMJ2-R with Encephalitozoon cuniculi. Folia Parasitol (Praha). 2007;54:172-6 pubmed
    ..activation of peritoneal macrophages by interferon gamma (IFN-gamma) resulted in the inhibition of Encephalitozoon cuniculi replication. However, E...
  47. Xu Y, Takvorian P, Cali A, Wang F, Zhang H, Orr G, et al. Identification of a new spore wall protein from Encephalitozoon cuniculi. Infect Immun. 2006;74:239-47 pubmed publisher
    ..SWP3 has several potential O-glycosylation sites, and it is possible that it is a mannosylated protein like the major polar tube protein (PTP1)...
  48. Sak B, Salat J, Horka H, Saková K, Ditrich O. Antibodies enhance the protective effect of CD4+ T lymphocytes in SCID mice perorally infected with Encephalitozoon cuniculi. Parasite Immunol. 2006;28:95-9 pubmed
    ..studied using a novel anti-exospore monoclonal antibody (MAb) P5/H1, which recognizes surface antigens of Encephalitozoon cuniculi. The effect of the MAb on microsporidial infection in vivo was to prolong the survival of previously CD4+ ..
  49. Taupin V, Metenier G, Delbac F, Vivares C, Prensier G. Expression of two cell wall proteins during the intracellular development of Encephalitozoon cuniculi: an immunocytochemical and in situ hybridization study with ultrathin frozen sections. Parasitology. 2006;132:815-25 pubmed
    The microsporidian Encephalitozoon cuniculi is an obligate intracellular parasite that develops asynchronously inside parasitophorous vacuoles...
  50. Moretto M, Weiss L, Khan I. Induction of a rapid and strong antigen-specific intraepithelial lymphocyte response during oral Encephalitozoon cuniculi infection. J Immunol. 2004;172:4402-9 pubmed
    b>Encephalitozoon cuniculi continues to pose a problem for immunocompromised patients. Previous studies from our laboratory have elucidated the importance of the CD8(+) T cell subset in the protection against systemic parasite infection...
  51. Dipineto L, Rinaldi L, Santaniello A, Sensale M, Cuomo A, Calabria M, et al. Serological survey for antibodies to Encephalitozoon cuniculi in pet rabbits in Italy. Zoonoses Public Health. 2008;55:173-5 pubmed publisher
    Pet rabbits (n = 125) from Southern Italy were submitted to a serological screening for Encephalitozoon cuniculi, using an enzyme-linked immunosorbent assay (ELISA) and a carbon immunoassay (CIA)...
  52. Xiao L, Li L, Visvesvara G, Moura H, Didier E, Lal A. Genotyping Encephalitozoon cuniculi by multilocus analyses of genes with repetitive sequences. J Clin Microbiol. 2001;39:2248-53 pubmed
    b>Encephalitozoon cuniculi infects a wide range of mammalian hosts...
  53. Ghosh K, Cappiello C, McBride S, Occi J, Cali A, Takvorian P, et al. Functional characterization of a putative aquaporin from Encephalitozoon cuniculi, a microsporidia pathogenic to humans. Int J Parasitol. 2006;36:57-62 pubmed
    ..An AQP-like sequence of the microsporidium Encephalitozoon cuniculi (EcAQP), when cloned and expressed in oocytes of Xenopus laevis, rendered these oocytes highly permeable ..
  54. Peyret P, Katinka M, Duprat S, Duffieux F, Barbe V, Barbazanges M, et al. Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora). Genome Res. 2001;11:198-207 pubmed
    A DNA sequencing program was applied to the small (<3 Mb) genome of the microsporidian Encephalitozoon cuniculi, an amitochondriate eukaryotic parasite of mammals, and the sequence of the smallest chromosome was determined...
  55. Zheng S, Hausmann S, Liu Q, Ghosh A, Schwer B, Lima C, et al. Mutational analysis of Encephalitozoon cuniculi mRNA cap (guanine-N7) methyltransferase, structure of the enzyme bound to sinefungin, and evidence that cap methyltransferase is the target of sinefungin's antifungal activity. J Biol Chem. 2006;281:35904-13 pubmed publisher
    ..Previous mutational and structural analyses of Encephalitozoon cuniculi Ecm1, a prototypal cellular cap methyltransferase, identified amino acids required for cap methylation in ..
  56. Dia N, Lavie L, Metenier G, Toguebaye B, Vivares C, Cornillot E. InterB multigenic family, a gene repertoire associated with subterminal chromosome regions of Encephalitozoon cuniculi and conserved in several human-infecting microsporidian species. Curr Genet. 2007;51:171-86 pubmed
    ..b>Encephalitozoon cuniculi harbours a very small genome (2.9 Mbp) with about 2,000 coding sequences (CDSs)...
  57. Harcourt Brown F, Holloway H. Encephalitozoon cuniculi in pet rabbits. Vet Rec. 2003;152:427-31 pubmed
    The results of a serological test for Encephalitozoon cuniculi in 125 pet rabbits are reviewed, together with follow-up studies of clinical cases...
  58. Furuya K, Miwa S, Omura M, Asakura T, Yamano K, Takatori K, et al. Mouse monoclonal immunoglobulin E antibodies specific for the microsporidian Encephalitozoon cuniculi polar tube protein 1. Hybridoma (Larchmt). 2008;27:153-7 pubmed publisher
    The microsporidian Encephalitozoon cuniculi is a spore-forming, obligate, intracellular parasitic pathogen with a unique organelle called a polar tube, the extrusion of which is essential for invading a host cell...
  59. Gamboa Dominguez A, De Anda J, Donis J, Ruiz Maza F, Visvesvara G, Diliz H. Disseminated encephalitozoon cuniculi infection in a Mexican kidney transplant recipient. Transplantation. 2003;75:1898-900 pubmed
    No cases of Encephalitozoon cuniculi infection have been reported in transplant patients.
  60. Tsaousis A, Kunji E, Goldberg A, Lucocq J, Hirt R, Embley T. A novel route for ATP acquisition by the remnant mitochondria of Encephalitozoon cuniculi. Nature. 2008;453:553-6 pubmed publisher
    ..Notably the genome of the microsporidian Encephalitozoon cuniculi has lost all of its genes for MCF proteins...
  61. Moretto M, Lawlor E, Khan I. Aging mice exhibit a functional defect in mucosal dendritic cell response against an intracellular pathogen. J Immunol. 2008;181:7977-84 pubmed
    ..present study, using a mouse model, we demonstrate that older animals exhibit greater susceptibility to Encephalitozoon cuniculi infection, and their ability to evoke an Ag-specific T cell response at the gut mucosal site is reduced...
  62. Cornillot E, Metenier G, Vivares C, Dassa E. Comparative analysis of sequences encoding ABC systems in the genome of the microsporidian Encephalitozoon cuniculi. FEMS Microbiol Lett. 2002;210:39-47 pubmed
    ..genes encoding ATP-binding cassette (ABC) systems was identified in the fully sequenced genome of Encephalitozoon cuniculi. Our analyses of multiple alignments, phylogenetic trees and conserved motifs support a distribution of E...