podospora

Summary

Summary: A genus of ascomycete FUNGI in the order SORDARIALES, which is found on SOIL and herbivore dung (FECES).

Top Publications

  1. Kunstmann B, Osiewacz H. Over-expression of an S-adenosylmethionine-dependent methyltransferase leads to an extended lifespan of Podospora anserina without impairments in vital functions. Aging Cell. 2008;7:651-62 pubmed publisher
    ..methyltransferase previously described to increase in abundance in total protein extracts during aging of Podospora anserina is demonstrated to accumulate in the mitochondrial cell fraction of senescent cultures...
  2. Van Diepeningen A, Slakhorst S, Koopmanschap A, Ikink G, Debets A, Hoekstra R. Calorie restriction in the filamentous fungus Podospora anserina. Exp Gerontol. 2010;45:516-24 pubmed publisher
    ..b>Podospora anserina is one of the few known ageing filamentous fungi and the ageing process and concomitant degeneration of ..
  3. Malagnac F, Lalucque H, Lepère G, Silar P. Two NADPH oxidase isoforms are required for sexual reproduction and ascospore germination in the filamentous fungus Podospora anserina. Fungal Genet Biol. 2004;41:982-97 pubmed
    ..we demonstrate the crucial role of these enzymes in the control of two key steps of the filamentous fungus Podospora anserina life cycle...
  4. Malagnac F, Klapholz B, Silar P. PaTrx1 and PaTrx3, two cytosolic thioredoxins of the filamentous ascomycete Podospora anserina involved in sexual development and cell degeneration. Eukaryot Cell. 2007;6:2323-31 pubmed
    ..Genes encoding thioredoxins were found by searching the complete genome sequence of the filamentous ascomycete Podospora anserina...
  5. Van Diepeningen A, Maas M, Huberts D, Goedbloed D, Engelmoer D, Slakhorst S, et al. Calorie restriction causes healthy life span extension in the filamentous fungus Podospora anserina. Mech Ageing Dev. 2010;131:60-8 pubmed publisher
    Although most fungi appear to be immortal, some show systemic senescence within a distinct time frame. Podospora anserina for example shows an irreversible growth arrest within weeks of culturing associated with a destabilization of the ..
  6. El Khoury R, Sellem C, Coppin E, Boivin A, Maas M, Debuchy R, et al. Gene deletion and allelic replacement in the filamentous fungus Podospora anserina. Curr Genet. 2008;53:249-58 pubmed publisher
    ..However, this event is rare in organisms like the filamentous fungus Podospora anserina...
  7. Soerensen M, Gredilla R, Müller Ohldach M, Werner A, Bohr V, Osiewacz H, et al. A potential impact of DNA repair on ageing and lifespan in the ageing model organism Podospora anserina: decrease in mitochondrial DNA repair activity during ageing. Mech Ageing Dev. 2009;130:487-96 pubmed publisher
    ..In the sexually reproducing ascomycete Podospora anserina ageing is, as in other eukaryotes, associated with mtDNA instability and mitochondrial dysfunction...
  8. Sellem C, Bovier E, Lorin S, Sainsard Chanet A. Mutations in two zinc-cluster proteins activate alternative respiratory and gluconeogenic pathways and restore senescence in long-lived respiratory mutants of Podospora anserina. Genetics. 2009;182:69-78 pubmed publisher
    In Podospora anserina, inactivation of the respiratory chain results in a spectacular life-span extension. This inactivation is accompanied by the induction of the alternative oxidase...
  9. Hamann A, Osiewacz H. Genetic analysis of spore killing in the filamentous ascomycete Podospora anserina. Fungal Genet Biol. 2004;41:1088-98 pubmed
    In the present study, we analysed different Podospora anserina strains for their ability to induce spore killing and identified three new killer strains...

More Information

Publications95

  1. Silar P. Peroxide accumulation and cell death in filamentous fungi induced by contact with a contestant. Mycol Res. 2005;109:137-49 pubmed
    b>Podospora anserina and Coprinopsis cinerea (syn. Coprinus cinereus) are endowed with a defence system able to differentiate self vs. non-self and involving the generation of peroxide...
  2. Müller Ohldach M, Brust D, Hamann A, Osiewacz H. Overexpression of PaParp encoding the poly(ADP-ribose) polymerase of Podospora anserina affects organismal aging. Mech Ageing Dev. 2011;132:33-42 pubmed publisher
    ..Here we report that PaPARP, the single protein with a PARP catalytic domain, in the fungal aging model Podospora anserina, indeed displays a NAD(+)-dependent poly(ADP-ribose) polymerase activity...
  3. Van Diepeningen A, Goedbloed D, Slakhorst S, Koopmanschap A, Maas M, Hoekstra R, et al. Mitochondrial recombination increases with age in Podospora anserina. Mech Ageing Dev. 2010;131:315-22 pubmed publisher
    ..A survey of wild-type isolates from a local population of the filamentous fungus Podospora anserina for the presence of seven optional mitochondrial introns indicated that mitochondrial recombination ..
  4. Brun S, Malagnac F, Bidard F, Lalucque H, Silar P. Functions and regulation of the Nox family in the filamentous fungus Podospora anserina: a new role in cellulose degradation. Mol Microbiol. 2009;74:480-96 pubmed publisher
    ..In this paper, we have identified a Podospora anserina mutant strain impaired for processes controlled by PaNox1 and PaNox2, the two Nox isoforms ..
  5. Aït Benkhali J, Coppin E, Brun S, Peraza Reyes L, Martin T, Dixelius C, et al. A network of HMG-box transcription factors regulates sexual cycle in the fungus Podospora anserina. PLoS Genet. 2013;9:e1003642 pubmed publisher
    ..The filamentous ascomycete Podospora anserina contains 12 HMG-box genes...
  6. Lalucque H, Malagnac F, Brun S, Kicka S, Silar P. A non-Mendelian MAPK-generated hereditary unit controlled by a second MAPK pathway in Podospora anserina. Genetics. 2012;191:419-33 pubmed publisher
    The Podospora anserina PaMpk1 MAP kinase (MAPK) signaling pathway can generate a cytoplasmic and infectious element resembling prions. When present in the cells, this C element causes the crippled growth (CG) cell degeneration...
  7. El Khoury R, Sainsard Chanet A. Suppression of mitochondrial DNA instability of autosomal dominant forms of progressive external ophthalmoplegia-associated ANT1 mutations in Podospora anserina. Genetics. 2009;183:861-71 pubmed publisher
    ..Here we show that the three adPEO-associated mutations equivalent to A114P, L98P, and V289M introduced into the Podospora anserina ANT1 ortholog dominantly cause severe growth defects, decreased reactive oxygen species production (ROS)..
  8. Osiewacz H, Brust D, Hamann A, Kunstmann B, Luce K, Müller Ohldach M, et al. Mitochondrial pathways governing stress resistance, life, and death in the fungal aging model Podospora anserina. Ann N Y Acad Sci. 2010;1197:54-66 pubmed publisher
    ..has unraveled a number of molecular pathways that are involved in controlling aging of the fungal model system Podospora anserina...
  9. Boisnard S, Espagne E, Zickler D, Bourdais A, Riquet A, Berteaux Lecellier V. Peroxisomal ABC transporters and beta-oxidation during the life cycle of the filamentous fungus Podospora anserina. Fungal Genet Biol. 2009;46:55-66 pubmed publisher
    ..In order to test their function in a fungus life cycle, we deleted the two Podospora anserina peroxisomal ABC transporter pABC1 and pABC2 genes as well as the three genes involved in peroxisomal (..
  10. Sen A, Baxa U, Simon M, Wall J, Sabate R, Saupe S, et al. Mass analysis by scanning transmission electron microscopy and electron diffraction validate predictions of stacked beta-solenoid model of HET-s prion fibrils. J Biol Chem. 2007;282:5545-50 pubmed
    ..In its prion form, the HET-s protein of Podospora anserina participates in a fungal self/non-self recognition phenomenon called heterokaryon incompatibility...
  11. Ritter C, Maddelein M, Siemer A, Luhrs T, Ernst M, Meier B, et al. Correlation of structural elements and infectivity of the HET-s prion. Nature. 2005;435:844-8 pubmed
    ..is now strongly supported by the recent findings that amyloid fibrils of recombinant prion proteins from yeast, Podospora anserina and mammals can induce prion phenotypes in the corresponding hosts...
  12. Scheckhuber C, Grief J, Boilan E, Luce K, Debacq Chainiaux F, Rittmeyer C, et al. Age-related cellular copper dynamics in the fungal ageing model Podospora anserina and in ageing human fibroblasts. PLoS ONE. 2009;4:e4919 pubmed publisher
    In previous investigations an impact of cellular copper homeostasis on ageing of the ascomycete Podospora anserina has been demonstrated. Here we provide new data indicating that mitochondria play a major role in this process...
  13. Sellem C, Marsy S, Boivin A, Lemaire C, Sainsard Chanet A. A mutation in the gene encoding cytochrome c1 leads to a decreased ROS content and to a long-lived phenotype in the filamentous fungus Podospora anserina. Fungal Genet Biol. 2007;44:648-58 pubmed
    We present here the properties of a complex III loss-of-function mutant of the filamentous fungus Podospora anserina...
  14. Brust D, Daum B, Breunig C, Hamann A, Kuhlbrandt W, Osiewacz H. Cyclophilin D links programmed cell death and organismal aging in Podospora anserina. Aging Cell. 2010;9:761-75 pubmed publisher
    ..CYPD abundance increases during aging in mammalian tissues and in the aging model organism Podospora anserina. Here, we show that treatment of the P...
  15. Bonnet C, Espagne E, Zickler D, Boisnard S, Bourdais A, Berteaux Lecellier V. The peroxisomal import proteins PEX2, PEX5 and PEX7 are differently involved in Podospora anserina sexual cycle. Mol Microbiol. 2006;62:157-69 pubmed
    ..shown previously that PEX2 deficiency leads to an impairment of meiotic commitment in the filamentous fungus Podospora anserina...
  16. Silar P. Grafting as a method for studying development in the filamentous fungus Podospora anserina. Fungal Biol. 2011;115:793-802 pubmed publisher
    ..study the interplay between mycelium and multicellular fruiting bodies during maturation in the model ascomycete Podospora anserina. Data indicate that grafts need a competent mycelium to continue their ripening...
  17. Pinan Lucarré B, Clavé C. Monitoring autophagy in the filamentous fungus Podospora anserina. Methods Enzymol. 2008;451:251-70 pubmed publisher
    Autophagy has been monitored in the filamentous fungus Podospora anserina using electron, light, and fluorescence microscopy...
  18. Sellem C, Lemaire C, Lorin S, Dujardin G, Sainsard Chanet A. Interaction between the oxa1 and rmp1 genes modulates respiratory complex assembly and life span in Podospora anserina. Genetics. 2005;169:1379-89 pubmed
    ..deficiency of the cytochrome respiratory pathway and life span was previously shown in the filamentous fungus Podospora anserina...
  19. Pinan Lucarré B, Paoletti M, Clavé C. Cell death by incompatibility in the fungus Podospora. Semin Cancer Biol. 2007;17:101-11 pubmed
    ..In Podospora anserina cell death by incompatibility is characterized by a dramatic vacuolar enlargement, induction of ..
  20. Strobel I, Breitenbach J, Scheckhuber C, Osiewacz H, Sandmann G. Carotenoids and carotenogenic genes in Podospora anserina: engineering of the carotenoid composition extends the life span of the mycelium. Curr Genet. 2009;55:175-84 pubmed publisher
    Carotenoids have been identified in the fungus Podospora anserina and a parallel pathway to neurosporene and beta-carotene was established. Three genes for the beta-carotene branch have been cloned and their function elucidated...
  21. Coppin E, Berteaux Lecellier V, Bidard F, Brun S, Ruprich Robert G, Espagne E, et al. Systematic deletion of homeobox genes in Podospora anserina uncovers their roles in shaping the fruiting body. PLoS ONE. 2012;7:e37488 pubmed publisher
    ..We identified all the homeobox genes in the filamentous ascomycete fungus Podospora anserina and constructed deletion mutants for each of these genes and for a number of gene combinations...
  22. Kowald A. The glyoxalase system as an example of a cellular maintenance pathway with relevance to aging. Aging (Albany NY). 2011;3:17-8 pubmed
  23. Pinan Lucarré B, Balguerie A, Clavé C. Accelerated cell death in Podospora autophagy mutants. Eukaryot Cell. 2005;4:1765-74 pubmed
    ..Cell death by incompatibility is characterized by a dramatic vacuolar enlargement and cell lysis. In Podospora anserina, autophagy is induced early during this cell death reaction...
  24. Scheckhuber C, Erjavec N, Tinazli A, Hamann A, Nystrom T, Osiewacz H. Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models. Nat Cell Biol. 2007;9:99-105 pubmed
    ..fission protein conserved from yeast to humans, affects ageing in the two model systems we studied, Podospora anserina and Saccharomyces cerevisiae...
  25. Balguerie A, Dos Reis S, Coulary Salin B, Chaignepain S, Sabourin M, Schmitter J, et al. The sequences appended to the amyloid core region of the HET-s prion protein determine higher-order aggregate organization in vivo. J Cell Sci. 2004;117:2599-610 pubmed
    The [Het-s] prion of the fungus Podospora anserina propagates as a self-perpetuating amyloid form of the HET-s protein...
  26. Mathur V, Seuring C, Riek R, Saupe S, Liebman S. Localization of HET-S to the cell periphery, not to [Het-s] aggregates, is associated with [Het-s]-HET-S toxicity. Mol Cell Biol. 2012;32:139-53 pubmed publisher
    ..Amyloid toxicity is also associated with fungal prions. In Podospora anserina, the simultaneous presence of [Het-s] prion and its allelic protein HET-S causes cell death in a self-/..
  27. Kicka S, Bonnet C, Sobering A, Ganesan L, Silar P. A mitotically inheritable unit containing a MAP kinase module. Proc Natl Acad Sci U S A. 2006;103:13445-50 pubmed
    ..Here, we provide further evidence that in the filamentous fungus Podospora anserina, a MAP kinase cascade is probably able to self-activate and generate C, a hereditary unit that bears ..
  28. Krause F, Scheckhuber C, Werner A, Rexroth S, Reifschneider N, Dencher N, et al. OXPHOS Supercomplexes: respiration and life-span control in the aging model Podospora anserina. Ann N Y Acad Sci. 2006;1067:106-15 pubmed
    ..of the respiratory chain of a wild-type strain and of two long-lived mutants of the filamentous fungus Podospora anserina. This aging model is able to respire by either the standard or the alternative pathway...
  29. Dequard Chablat M, Sellem C, Golik P, Bidard F, Martos A, Bietenhader M, et al. Two nuclear life cycle-regulated genes encode interchangeable subunits c of mitochondrial ATP synthase in Podospora anserina. Mol Biol Evol. 2011;28:2063-75 pubmed publisher
    ..Interestingly, we found that in Podospora anserina, subunit c is exclusively produced from two nuclear genes (PaAtp9-5 and PaAtp9-7), which display ..
  30. Scheckhuber C, Mack S, Strobel I, Ricciardi F, Gispert S, Osiewacz H. Modulation of the glyoxalase system in the aging model Podospora anserina: effects on growth and lifespan. Aging (Albany NY). 2010;2:969-80 pubmed
    ..Overall, our results identify the up-regulation of both components of the glyoxalase system as an effective intervention to increase lifespan in P. anserina...
  31. Hamann A, Krause K, Werner A, Osiewacz H. A two-step protocol for efficient deletion of genes in the filamentous ascomycete Podospora anserina. Curr Genet. 2005;48:270-5 pubmed
    Deletion of genes in Podospora anserina via conventional methods is an inefficient and time-consuming process since homologous recombination occurs normally only at low frequency (about 1%)...
  32. Lambou K, Malagnac F, Barbisan C, Tharreau D, Lebrun M, Silar P. The crucial role of the Pls1 tetraspanin during ascospore germination in Podospora anserina provides an example of the convergent evolution of morphogenetic processes in fungal plant pathogens and saprobes. Eukaryot Cell. 2008;7:1809-18 pubmed publisher
    ..We show here that Podospora anserina, a saprobic fungus lacking appressorium, contains PaPls1, a gene orthologous to known PLS1 genes...
  33. Adam C, Picard M, Dequard Chablat M, Sellem C, Hermann Le Denmat S, Contamine V. Biological roles of the Podospora anserina mitochondrial Lon protease and the importance of its N-domain. PLoS ONE. 2012;7:e38138 pubmed publisher
    ..Despite the presence of ClpXP in the filamentous fungus Podospora anserina, deletion of the gene encoding the other matricial protease, PaLon1, leads to lethality at high and low ..
  34. Bidard F, Clavé C, Saupe S. The transcriptional response to nonself in the fungus Podospora anserina. G3 (Bethesda). 2013;3:1015-30 pubmed publisher
    ..Herein, we analyze the transcriptional changes during the incompatibility reaction in Podospora anserina...
  35. Bouhouche K, Zickler D, Debuchy R, Arnaise S. Altering a gene involved in nuclear distribution increases the repeat-induced point mutation process in the fungus Podospora anserina. Genetics. 2004;167:151-9 pubmed
    ..Both are active over the sexual cycle of some filamentous fungi, e.g., Neurospora crassa and Podospora anserina...
  36. Weil A, Luce K, Dröse S, Wittig I, Brandt U, Osiewacz H. Unmasking a temperature-dependent effect of the P. anserina i-AAA protease on aging and development. Cell Cycle. 2011;10:4280-90 pubmed publisher
    ..protease is part of such a surveillance system and PaIAP is the putative ortholog in the fungal aging model Podospora anserina. Here we investigated the role of PaIAP in aging and development...
  37. Zintel S, Bernhardt D, Rogowska Wrzesinska A, Osiewacz H. PaCATB, a secreted catalase protecting Podospora anserina against exogenous oxidative stress. Aging (Albany NY). 2011;3:768-81 pubmed
    A differential mass spectrometry analysis of secreted proteins from juvenile and senescent Podospora anserina cultures revealed age-related differences in protein profiles...
  38. Bidard F, Aït Benkhali J, Coppin E, Imbeaud S, Grognet P, Delacroix H, et al. Genome-wide gene expression profiling of fertilization competent mycelium in opposite mating types in the heterothallic fungus Podospora anserina. PLoS ONE. 2011;6:e21476 pubmed publisher
    ..The heterothallic fungus Podospora anserina serves as a model for understanding the basic features of mating-type control...
  39. Couturier M, Haon M, Coutinho P, Henrissat B, Lesage Meessen L, Berrin J. Podospora anserina hemicellulases potentiate the Trichoderma reesei secretome for saccharification of lignocellulosic biomass. Appl Environ Microbiol. 2011;77:237-46 pubmed publisher
    ..a set of genes encoding putative polysaccharide-degrading enzymes were selected from the coprophilic fungus Podospora anserina using comparative genomics...
  40. Lorin S, Dufour E, Sainsard Chanet A. Mitochondrial metabolism and aging in the filamentous fungus Podospora anserina. Biochim Biophys Acta. 2006;1757:604-10 pubmed
    The filamentous fungus Podospora anserina has a limited lifespan. In this organism, aging is systematically associated to mitochondrial DNA instability...
  41. Boivin A, Gaumer S, Sainsard Chanet A. Life span extension by dietary restriction is reduced but not abolished by loss of both SIR2 and HST2 in Podospora anserina. Mech Ageing Dev. 2008;129:714-21 pubmed publisher
    ..In this paper, we studied the relationship between SIR2 and DR in the filamentous fungus Podospora anserina. We show that the loss of PaSir2, PaHst2 or PaPnc1 does not alter life span under standard conditions...
  42. Saupe S. A short history of small s: a prion of the fungus Podospora anserina. Prion. 2007;1:110-5 pubmed
    ..The [Het-s] cytoplasmic genetic element of the filamentous fungus Podospora anserina, was originally identified in 1952 and recognized as a prion nearly half a century later...
  43. Mizuno N, Baxa U, Steven A. Structural dependence of HET-s amyloid fibril infectivity assessed by cryoelectron microscopy. Proc Natl Acad Sci U S A. 2011;108:3252-7 pubmed publisher
    HET-s is a prion protein of the fungus Podospora anserina which, in the prion state, is active in a self/nonself recognition process called heterokaryon incompatibility...
  44. Jamet Vierny C, Debuchy R, Prigent M, Silar P. IDC1, a pezizomycotina-specific gene that belongs to the PaMpk1 MAP kinase transduction cascade of the filamentous fungus Podospora anserina. Fungal Genet Biol. 2007;44:1219-30 pubmed
    ..In addition, heterokaryon construction shows that IDC1 is necessary together with PaNox1 in the perithecial envelope but not in the dikaryon resulting from fertilization...
  45. Dalstra H, van der Zee R, Swart K, Hoekstra R, Saupe S, Debets A. Non-mendelian inheritance of the HET-s prion or HET-s prion domains determines the het-S spore killing system in Podospora anserina. Fungal Genet Biol. 2005;42:836-47 pubmed
    Two alleles of the het-s/S locus occur naturally in the filamentous fungus Podospora anserina, het-s and het-S...
  46. Chevanne D, Saupe S, Clavé C, Paoletti M. WD-repeat instability and diversification of the Podospora anserina hnwd non-self recognition gene family. BMC Evol Biol. 2010;10:134 pubmed publisher
    ..In the fungus Podospora anserina, three genes controlling this allorecognition process het-d, het-e and het-r are paralogs belonging to ..
  47. Osiewacz H, Hamann A, Zintel S. Assessing organismal aging in the filamentous fungus Podospora anserina. Methods Mol Biol. 2013;965:439-62 pubmed publisher
    b>Podospora anserina is an extensively studied model organism to unravel the mechanism of organismal aging. This filamentous fungus is short-lived and accessible to experimentation...
  48. Scheckhuber C, Osiewacz H. Podospora anserina: a model organism to study mechanisms of healthy ageing. Mol Genet Genomics. 2008;280:365-74 pubmed publisher
    The filamentous ascomycete Podospora anserina has been extensively studied as an experimental ageing model for more than 50 years...
  49. Dementhon K, Saupe S, Clavé C. Characterization of IDI-4, a bZIP transcription factor inducing autophagy and cell death in the fungus Podospora anserina. Mol Microbiol. 2004;53:1625-40 pubmed
    ..This phenomenon is referred to as heterokaryon incompatibility. In Podospora anserina, this cell death reaction was found to be associated with the transcriptional induction of a set of ..
  50. Coppin E, de Renty C, Debuchy R. The function of the coding sequences for the putative pheromone precursors in Podospora anserina is restricted to fertilization. Eukaryot Cell. 2005;4:407-20 pubmed
    We cloned the pheromone precursor genes of Podospora anserina in order to elucidate their role in the biology of this fungus...
  51. Gredilla R, Grief J, Osiewacz H. Mitochondrial free radical generation and lifespan control in the fungal aging model Podospora anserina. Exp Gerontol. 2006;41:439-47 pubmed
    In the filamentous fungus Podospora anserina a central role of mitochondria in the control of aging has been repeatedly demonstrated...
  52. Maas M, Sellem C, Hoekstra R, Debets A, Sainsard Chanet A. Integration of a pAL2-1 homologous mitochondrial plasmid associated with life span extension in Podospora anserina. Fungal Genet Biol. 2007;44:659-71 pubmed
    We isolated and characterized a novel spontaneous longevity mutant of Podospora anserina strain Wa32 carrying one of the pAL2-1 homologous mitochondrial plasmids...
  53. Scheckhuber C, Houthoofd K, Weil A, Werner A, De Vreese A, Vanfleteren J, et al. Alternative oxidase dependent respiration leads to an increased mitochondrial content in two long-lived mutants of the aging model Podospora anserina. PLoS ONE. 2011;6:e16620 pubmed publisher
    ..In the filamentous ascomycete Podospora anserina, an example for such a response is the induction of a nuclear-encoded and iron-dependent alternative ..
  54. Groebe K, Krause F, Kunstmann B, Unterluggauer H, Reifschneider N, Scheckhuber C, et al. Differential proteomic profiling of mitochondria from Podospora anserina, rat and human reveals distinct patterns of age-related oxidative changes. Exp Gerontol. 2007;42:887-98 pubmed
    ..a differential comparison of mitochondrial proteins from young and senescent strains of the fungal ageing model Podospora anserina, from brains of young (5 months) vs...
  55. Osiewacz H. Mitochondrial quality control in aging and lifespan control of the fungal aging model Podospora anserina. Biochem Soc Trans. 2011;39:1488-92 pubmed publisher
    ..In the filamentous fungus Podospora anserina, a model in which organismal aging can conveniently be analysed, mitochondria play a central role...
  56. Paoletti M, Clave C. The fungus-specific HET domain mediates programmed cell death in Podospora anserina. Eukaryot Cell. 2007;6:2001-8 pubmed
    ..The nonallelic het-C/het-E incompatibility system is the best-characterized incompatibility system in Podospora anserina...
  57. Arnaise S, Zickler D, Bourdais A, Dequard Chablat M, Debuchy R. Mutations in mating-type genes greatly decrease repeat-induced point mutation process in the fungus Podospora anserina. Fungal Genet Biol. 2008;45:207-20 pubmed
  58. Scheckhuber C, Rödel E, Wüstehube J. Regulation of mitochondrial dynamics--characterization of fusion and fission genes in the ascomycete Podospora anserina. Biotechnol J. 2008;3:781-90 pubmed publisher
    The filamentous ascomycete Podospora anserina is a model system for studying aging, a complex process that is regulated by multiple factors. Among these, mitochondria were shown to be of crucial importance...
  59. Kunstmann B, Osiewacz H. The S-adenosylmethionine dependent O-methyltransferase PaMTH1: a longevity assurance factor protecting Podospora anserina against oxidative stress. Aging (Albany NY). 2009;1:328-34 pubmed
    ..The protein accumulates during ageing of Podospora anserina in both the cytosol and in the mitochondrial matrix...
  60. Peraza Reyes L, Zickler D, Berteaux Lecellier V. The peroxisome RING-finger complex is required for meiocyte formation in the fungus Podospora anserina. Traffic. 2008;9:1998-2009 pubmed publisher
    ..Peroxisomes are involved in a variety of metabolic pathways and developmental processes. In the filamentous fungus Podospora anserina, absence of different peroxins implicated in peroxisome matrix protein import leads to different ..
  61. Paoletti M, Saupe S. The genome sequence of Podospora anserina, a classic model fungus. Genome Biol. 2008;9:223 pubmed publisher
    The completed genome sequence of the coprophilous fungus Podospora anserina increases the sampling of fungal genomes...
  62. Daskalov A, Paoletti M, Ness F, Saupe S. Genomic clustering and homology between HET-S and the NWD2 STAND protein in various fungal genomes. PLoS ONE. 2012;7:e34854 pubmed publisher
    Prions are infectious proteins propagating as self-perpetuating amyloid polymers. The [Het-s] prion of Podospora anserina is involved in a cell death process associated with non-self recognition...
  63. Dobson C. Structural biology: prying into prions. Nature. 2005;435:747-9 pubmed
  64. Slot J, Rokas A. Horizontal transfer of a large and highly toxic secondary metabolic gene cluster between fungi. Curr Biol. 2011;21:134-9 pubmed publisher
    ..We discovered that a complete ST gene cluster in Podospora anserina was horizontally transferred from Aspergillus...
  65. Peraza Reyes L, Arnaise S, Zickler D, Coppin E, Debuchy R, Berteaux Lecellier V. The importomer peroxins are differentially required for peroxisome assembly and meiotic development in Podospora anserina: insights into a new peroxisome import pathway. Mol Microbiol. 2011;82:365-77 pubmed publisher
    ..In the fungus Podospora anserina, the RING-finger peroxins are crucial for meiocyte formation, while PEX5, PEX7 or the docking peroxin ..
  66. Zintel S, Schwitalla D, Luce K, Hamann A, Osiewacz H. Increasing mitochondrial superoxide dismutase abundance leads to impairments in protein quality control and ROS scavenging systems and to lifespan shortening. Exp Gerontol. 2010;45:525-32 pubmed publisher
    The fungal aging model Podospora anserina contains three superoxide dismutases (SODs) in different cellular compartments...
  67. Espagne E, Lespinet O, Malagnac F, Da Silva C, Jaillon O, Porcel B, et al. The genome sequence of the model ascomycete fungus Podospora anserina. Genome Biol. 2008;9:R77 pubmed publisher
    The dung-inhabiting ascomycete fungus Podospora anserina is a model used to study various aspects of eukaryotic and fungal biology, such as ageing, prions and sexual development.
  68. Dementhon K, Saupe S. DNA-binding specificity of the IDI-4 basic leucine zipper factor of Podospora anserina defined by systematic evolution of ligands by exponential enrichment (SELEX). Eukaryot Cell. 2005;4:476-83 pubmed
    ..In Podospora anserina, autophagy is engaged during cell death by incompatibility and a number of genes are induced at the ..
  69. Song K, Okuyama M, Kobayashi K, Mori H, Kimura A. Characterization of a glycoside hydrolase family 31 ?-glucosidase involved in starch utilization in Podospora anserina. Biosci Biotechnol Biochem. 2013;77:2117-24 pubmed
    For Podospora anserina, several studies of cellulolytic enzymes have been established, but characteristics of amylolytic enzymes are not well understood. When P...
  70. Hamann A, Brust D, Osiewacz H. Deletion of putative apoptosis factors leads to lifespan extension in the fungal ageing model Podospora anserina. Mol Microbiol. 2007;65:948-58 pubmed
    b>Podospora anserina is a filamentous fungus with a limited lifespan. After a strain-specific period of growth, cultures turn to senescence and ultimately die. Here we provide evidence that the last step in the ageing of P...
  71. Luce K, Osiewacz H. Increasing organismal healthspan by enhancing mitochondrial protein quality control. Nat Cell Biol. 2009;11:852-8 pubmed publisher
    ..Here we describe the regulation of Podospora anserina LON (PaLON) levels, an AAA(+) family serine protease localized in the matrix fraction of mitochondria...
  72. Wasmer C, Zimmer A, Sabate R, Soragni A, Saupe S, Ritter C, et al. Structural similarity between the prion domain of HET-s and a homologue can explain amyloid cross-seeding in spite of limited sequence identity. J Mol Biol. 2010;402:311-25 pubmed publisher
    ..The domain FgHET-s(218-289), which corresponds to the prion domain in HET-s from Podospora anserina, forms amyloid fibrils in vitro and is able to efficiently cross-seed HET-s(218-289) prion formation...
  73. Wasmer C, Lange A, Van Melckebeke H, Siemer A, Riek R, Meier B. Amyloid fibrils of the HET-s(218-289) prion form a beta solenoid with a triangular hydrophobic core. Science. 2008;319:1523-6 pubmed publisher
    ..fibrils from the prion-forming domain (residues 218 to 289) of the HET-s protein from the filamentous fungus Podospora anserina...
  74. Chevanne D, Bastiaans E, Debets A, Saupe S, Clavé C, Paoletti M. Identification of the het-r vegetative incompatibility gene of Podospora anserina as a member of the fast evolving HNWD gene family. Curr Genet. 2009;55:93-102 pubmed publisher
    ..In Podospora anserina, three non-allelic incompatibility systems have been genetically defined involving interactions between ..
  75. Van Diepeningen A, Debets A, Slakhorst S, Hoekstra R. Mitochondrial pAL2-1 plasmid homologs are senescence factors in Podospora anserina independent of intrinsic senescence. Biotechnol J. 2008;3:791-802 pubmed publisher
    Since the first description of a linear mitochondrial plasmid in Podospora anserina, pAL2-1, and homologous plasmids have gone from being considered beneficial longevity plasmids, via neutral genetic elements, toward mutator plasmids ..
  76. Bidard F, Coppin E, Silar P. The transcriptional response to the inactivation of the PaMpk1 and PaMpk2 MAP kinase pathways in Podospora anserina. Fungal Genet Biol. 2012;49:643-52 pubmed publisher
    Transcription pattern during mycelium growth of Podospora anserina was assayed by microarray analysis in wild type and in mutants affected in the MAP kinase genes PaMpk1 and PaMpk2 and in the NADPH oxidase gene PaNox1...
  77. Bey M, Zhou S, Poidevin L, Henrissat B, Coutinho P, Berrin J, et al. Cello-oligosaccharide oxidation reveals differences between two lytic polysaccharide monooxygenases (family GH61) from Podospora anserina. Appl Environ Microbiol. 2013;79:488-96 pubmed publisher
    The genome of the coprophilic ascomycete Podospora anserina encodes 33 different genes encoding copper-dependent lytic polysaccharide monooxygenases (LPMOs) from glycoside hydrolase family 61 (GH61)...
  78. Coppin E, Silar P. Identification of PaPKS1, a polyketide synthase involved in melanin formation and its use as a genetic tool in Podospora anserina. Mycol Res. 2007;111:901-8 pubmed
    In the filamentous fungus Podospora anserina, many pigmentation mutations map to the median region of the complex locus '14', called segment '29'...
  79. Pinan Lucarré B, Iraqui I, Clavé C. Podospora anserina target of rapamycin. Curr Genet. 2006;50:23-31 pubmed
    We have isolated the Podospora anserina TOR gene. The PaTOR protein displayed strong identities with TOR proteins from other eukaryotes especially in the FRB domain and the kinase domain...
  80. Osiewacz H, Scheckhuber C. Impact of ROS on ageing of two fungal model systems: Saccharomyces cerevisiae and Podospora anserina. Free Radic Res. 2006;40:1350-8 pubmed
    ..ageing in two fungal models, the unicellular ascomycete Saccharomyces cerevisiae and the filamentous ascomycete Podospora anserina...
  81. Paoletti M, Saupe S. Fungal incompatibility: evolutionary origin in pathogen defense?. Bioessays. 2009;31:1201-10 pubmed publisher
    ..In Podospora anserina, the genes controlling this process belong to a gene family encoding STAND proteins with an N-terminal ..
  82. Seuring C, Greenwald J, Wasmer C, Wepf R, Saupe S, Meier B, et al. The mechanism of toxicity in HET-S/HET-s prion incompatibility. PLoS Biol. 2012;10:e1001451 pubmed publisher
    The HET-s protein from the filamentous fungus Podospora anserina is a prion involved in a cell death reaction termed heterokaryon incompatibility...
  83. Scheckhuber C, Mitterbauer R, Osiewacz H. Molecular basis of and interference into degenerative processes in fungi: potential relevance for improving biotechnological performance of microorganisms. Appl Microbiol Biotechnol. 2009;85:27-35 pubmed publisher
    ..Studying the mechanistic basis of degenerative processes in the filamentous ascomycete Podospora anserina and in other systems demonstrated that mitochondria play a key role in the expression of degenerative ..
  84. Brust D, Hamann A, Osiewacz H. Deletion of PaAif2 and PaAmid2, two genes encoding mitochondrial AIF-like oxidoreductases of Podospora anserina, leads to increased stress tolerance and lifespan extension. Curr Genet. 2010;56:225-35 pubmed publisher
    Wild-type strains of the ascomycete Podospora anserina are characterized by a limited lifespan...
  85. Matasyoh J, Dittrich B, Schueffler A, Laatsch H. Larvicidal activity of metabolites from the endophytic Podospora sp. against the malaria vector Anopheles gambiae. Parasitol Res. 2011;108:561-6 pubmed publisher
    In a screening for natural products with mosquito larvicidal activities, the endophytic fungus Podospora sp. isolated from the plant Laggera alata (Asteraceae) was conspicuous...
  86. Saupe S. The [Het-s] prion of Podospora anserina and its role in heterokaryon incompatibility. Semin Cell Dev Biol. 2011;22:460-8 pubmed publisher
    Het-s] is a prion from the filamentous fungus Podospora anserina and corresponds to a self-perpetuating amyloid aggregate of the HET-s protein...