neurospora

Summary

Summary: A genus of ascomycetous fungi, family Sordariaceae, order SORDARIALES, comprising bread molds. They are capable of converting tryptophan to nicotinic acid and are used extensively in genetic and enzyme research. (Dorland, 27th ed)

Top Publications

  1. Dettman J, Jacobson D, Turner E, Pringle A, Taylor J. Reproductive isolation and phylogenetic divergence in Neurospora: comparing methods of species recognition in a model eukaryote. Evolution. 2003;57:2721-41 pubmed
    We critically examined methods for recognizing species in the model filamentous fungal genus Neurospora by comparing traditional biological species recognition (BSR) with more comprehensive applications of both BSR and phylogenetic ..
  2. Hammond T, Rehard D, Xiao H, Shiu P. Molecular dissection of Neurospora Spore killer meiotic drive elements. Proc Natl Acad Sci U S A. 2012;109:12093-8 pubmed publisher
    ..In Neurospora, meiotic drive can be observed in fungal spore killing...
  3. Keeping A, Collins R. Evidence for the phenotypic neutrality of the Neurospora Varkud (V) and Varkud satellite (VS) plasmids. Fungal Genet Biol. 2011;48:741-6 pubmed publisher
    ..requires the Varkud (V) plasmid for replication, is found in the mitochondria of several natural isolates of Neurospora. The VS transcript is sufficiently abundant that it might be expected to alter the function of mitochondria; ..
  4. Videira A, Werner S. Assembly kinetics and identification of precursor proteins of complex I from Neurospora crassa. Eur J Biochem. 1989;181:493-502 pubmed
    Complex I from Neurospora crassa was fractionated using chaotropic agents and various chromatographic techniques. Several subunits were isolated...
  5. Jones C, Borkovich K. Analysis of mitogen-activated protein kinase phosphorylation in response to stimulation of histidine kinase signaling pathways in Neurospora. Methods Enzymol. 2010;471:319-34 pubmed publisher
    ..The protein extraction method presented may also be used to concentrate cellular proteins for additional applications, such as metabolic labeling or analysis of other posttranslational modifications. ..
  6. Andersen A, Collins R. Intramolecular secondary structure rearrangement by the kissing interaction of the Neurospora VS ribozyme. Proc Natl Acad Sci U S A. 2001;98:7730-5 pubmed
  7. Vogt N, Seiler S. The RHO1-specific GTPase-activating protein LRG1 regulates polar tip growth in parallel to Ndr kinase signaling in Neurospora. Mol Biol Cell. 2008;19:4554-69 pubmed publisher
    ..Here, we investigated the role of LRG1, a novel member of the GTPase-activating proteins (GAPs) of Neurospora crassa...
  8. Powell A, Jacobson D, Natvig D. Ancestral polymorphism and linkage disequilibrium at the het-6 region in pseudohomothallic Neurospora tetrasperma. Fungal Genet Biol. 2007;44:896-904 pubmed
    In species of Neurospora, non-self recognition is mediated by at least 11 heterokaryon (het) incompatibility loci. Previously, we identified ancient allelic variation at het-c in pseudohomothallic N...
  9. Diernfellner A, Colot H, Dintsis O, Loros J, Dunlap J, Brunner M. Long and short isoforms of Neurospora clock protein FRQ support temperature-compensated circadian rhythms. FEBS Lett. 2007;581:5759-64 pubmed
    The large (l) and small (s) isoforms of FREQUENCY (FRQ) are elements of interconnected feedback loops of the Neurospora circadian clock. The expression ratio of l-FRQ vs...

More Information

Publications122 found, 100 shown here

  1. Liu Y. Molecular mechanisms of entrainment in the Neurospora circadian clock. J Biol Rhythms. 2003;18:195-205 pubmed
    Light and temperature are 2 of the most important environmental influences on all circadian clocks, and Neurospora provides an excellent system for understanding their effects...
  2. Shi M, Larrondo L, Loros J, Dunlap J. A developmental cycle masks output from the circadian oscillator under conditions of choline deficiency in Neurospora. Proc Natl Acad Sci U S A. 2007;104:20102-7 pubmed
    In Neurospora, metabolic oscillators coexist with the circadian transcriptional/translational feedback loop governed by the FRQ (Frequency) and WC (White Collar) proteins...
  3. Poon A, Olive J, McLaren M, Collins R. Identification of separate structural features that affect rate and cation concentration dependence of self-cleavage by the Neurospora VS ribozyme. Biochemistry. 2006;45:13394-400 pubmed
    The cleavage site of the Neurospora VS ribozyme is located in an internal loop in a hairpin called stem-loop I...
  4. Maguire J, Collins R. Effects of cobalt hexammine on folding and self-cleavage of the Neurospora VS ribozyme. J Mol Biol. 2001;309:45-56 pubmed
    We have investigated the effects of Co(NH3)6(3+), an analog of hexahydrated Mg2+, on folding and catalysis of the Neurospora VS ribozyme...
  5. Lerch K. Neurospora tyrosinase: structural, spectroscopic and catalytic properties. Mol Cell Biochem. 1983;52:125-38 pubmed
    ..This review deals with the recent progress on the molecular structure of the enzyme from Neurospora crassa and the unique features of the binuclear active site copper complex involved in the activation of ..
  6. Hoffmann B, Mitchell G, Gendron P, Major F, Andersen A, Collins R, et al. NMR structure of the active conformation of the Varkud satellite ribozyme cleavage site. Proc Natl Acad Sci U S A. 2003;100:7003-8 pubmed
    Substrate cleavage by the Neurospora Varkud satellite (VS) ribozyme involves a structural change in the stem-loop I substrate from an inactive to an active conformation...
  7. Maheshwari R, Navaraj A. Senescence in fungi: the view from Neurospora. FEMS Microbiol Lett. 2008;280:135-43 pubmed
    Some naturally occurring strains of fungi cease growing through successive subculturing, i.e., they senesce. In Neurospora, senescing strains usually contain intramitochondrial linear or circular plasmids...
  8. Paietta J. Molecular cloning and regulatory analysis of the arylsulfatase structural gene of Neurospora crassa. Mol Cell Biol. 1989;9:3630-7 pubmed
    The ars-1+ gene of Neurospora crassa encodes the enzyme arylsulfatase...
  9. Selker E, Freitag M, Kothe G, Margolin B, Rountree M, Allis C, et al. Induction and maintenance of nonsymmetrical DNA methylation in Neurospora. Proc Natl Acad Sci U S A. 2002;99 Suppl 4:16485-90 pubmed
    ..Most methylated regions of the Neurospora genome that have been examined are products of repeat-induced point mutation, a premeiotic genome defense system ..
  10. Querfurth C, Diernfellner A, Heise F, Lauinger L, Neiss A, Tataroglu O, et al. Posttranslational regulation of Neurospora circadian clock by CK1a-dependent phosphorylation. Cold Spring Harb Symp Quant Biol. 2007;72:177-83 pubmed publisher
    ..White Collar Complex (WCC), are essential components of interconnected feedback loops of the circadian clock of Neurospora. In a negative feedback loop, FRQ inhibits the WCC by recruiting casein kinase 1a (CK1a) and supporting its ..
  11. Yang Y, Cheng P, Liu Y. Regulation of the Neurospora circadian clock by casein kinase II. Genes Dev. 2002;16:994-1006 pubmed
    Phosphorylation of clock proteins represents an important mechanism regulating circadian clocks. In Neurospora, clock protein FREQUENCY (FRQ) is progressively phosphorylated over time, and its level decreases when it is extensively ..
  12. Franchi L, Fulci V, Macino G. Protein kinase C modulates light responses in Neurospora by regulating the blue light photoreceptor WC-1. Mol Microbiol. 2005;56:334-45 pubmed
    The Neurospora protein kinase C (NPKC) is a regulator of light responsive genes...
  13. Germann U, Lerch K. Isolation and partial nucleotide sequence of the laccase gene from Neurospora crassa: amino acid sequence homology of the protein to human ceruloplasmin. Proc Natl Acad Sci U S A. 1986;83:8854-8 pubmed
    The laccase (benzenediol:oxygen oxidoreductase, EC 1.10.3.2) gene from Neurospora crassa was cloned and part of its nucleotide sequence corresponding to the carboxyl-terminal region of the protein has been determined...
  14. García D, Stchigel A, Cano J, Guarro J, Hawksworth D. A synopsis and re-circumscription of Neurospora (syn. Gelasinospora) based on ultrastructural and 28S rDNA sequence data. Mycol Res. 2004;108:1119-42 pubmed
    b>Neurospora and Gelasinospora are traditionally distinguished by the ornamentation pattern of the surface of their ascospores, which are ribbed in the former and pitted in the latter...
  15. Catalanotto C, Azzalin G, Macino G, Cogoni C. Involvement of small RNAs and role of the qde genes in the gene silencing pathway in Neurospora. Genes Dev. 2002;16:790-5 pubmed
    ..Here, we find that small sense and antisense RNAs are also involved in PTGS in Neurospora crassa...
  16. Zamel R, Poon A, Jaikaran D, Andersen A, Olive J, De Abreu D, et al. Exceptionally fast self-cleavage by a Neurospora Varkud satellite ribozyme. Proc Natl Acad Sci U S A. 2004;101:1467-72 pubmed
    ..We have identified variants of one of these, the Neurospora Varkud satellite ribozyme, that self-cleaves with experimentally measured apparent rate constants of up to 10 s(-..
  17. Kumar K, Ravi Kumar B, Siddavattam D, Subramanyam C. Characterization of calcineurin-dependent response element binding protein and its involvement in copper-metallothionein gene expression in Neurospora. Biochem Biophys Res Commun. 2006;345:1010-3 pubmed publisher
    ..response element (CDRE) in the -3730bp upstream region of copper-induced metallothionein (CuMT) gene of Neurospora [K.S. Kumar, S. Dayananda, C...
  18. Olive J, de Abreu D, Rastogi T, Andersen A, Mittermaier A, Beattie T, et al. Enhancement of Neurospora VS ribozyme cleavage by tuberactinomycin antibiotics. EMBO J. 1995;14:3247-51 pubmed
    ..basic, cyclic peptide antibiotic of the tuberactinomycin group, enhance the cleavage of a ribozyme derived from Neurospora VS RNA. Viomycin decreases by an order of magnitude the concentration of magnesium required for cleavage...
  19. Schafmeier T, Diernfellner A, Schäfer A, Dintsis O, Neiss A, Brunner M. Circadian activity and abundance rhythms of the Neurospora clock transcription factor WCC associated with rapid nucleo-cytoplasmic shuttling. Genes Dev. 2008;22:3397-402 pubmed publisher
    The Neurospora clock protein FREQUENCY (FRQ) inhibits its transcriptional activator WHITE COLLAR COMPLEX (WCC) in a negative feedback loop and supports its accumulation in a positive loop...
  20. Whittle C, Sun Y, Johannesson H. Evolution of synonymous codon usage in Neurospora tetrasperma and Neurospora discreta. Genome Biol Evol. 2011;3:332-43 pubmed publisher
    b>Neurospora comprises a primary model system for the study of fungal genetics and biology. In spite of this, little is known about genome evolution in Neurospora...
  21. Raju N. Neurospora as a model fungus for studies in cytogenetics and sexual biology at Stanford. J Biosci. 2009;34:139-59 pubmed
    Dodge's early work (1927-1940) on Neurospora genetics and sexual biology inspired Beadle and Tatum at Stanford to use N.crassa for their landmark discovery that genes specify enzymes...
  22. Loros J. Time at the end of the millennium: the Neurospora clock. Curr Opin Microbiol. 1998;1:698-706 pubmed
    ..Rapid progress in understanding the Neurospora clock has been complemented by a flood of information from diverse systems including cyanobacteria, insects and ..
  23. Káldi K, González B, Brunner M. Transcriptional regulation of the Neurospora circadian clock gene wc-1 affects the phase of circadian output. EMBO Rep. 2006;7:199-204 pubmed
    WHITE COLLAR-1 (WC-1) is the limiting component of the White Collar Complex (WCC) controlling expression of the Neurospora circadian clock protein Frequency (FRQ). Accumulation of WC-1 is supported by FRQ on a post-transcriptional level...
  24. Turner E, Jacobson D, Taylor J. Reinforced postmating reproductive isolation barriers in Neurospora, an Ascomycete microfungus. J Evol Biol. 2010;23:1642-56 pubmed publisher
    ..We examined geographical patterns in reproductive isolation barriers between Neurospora crassa and Neurospora intermedia, fungi with pheromone-mediated mate recognition and maternal care...
  25. Colot H, Park G, Turner G, Ringelberg C, Crew C, Litvinkova L, et al. A high-throughput gene knockout procedure for Neurospora reveals functions for multiple transcription factors. Proc Natl Acad Sci U S A. 2006;103:10352-10357 pubmed publisher
    ..describe a method for rapidly creating knockout mutants in which we make use of yeast recombinational cloning, Neurospora mutant strains deficient in nonhomologous end-joining DNA repair, custom-written software tools, and robotics...
  26. Pöggeler S. Phylogenetic relationships between mating-type sequences from homothallic and heterothallic ascomycetes. Curr Genet. 1999;36:222-31 pubmed
    ..The study included nine homothallic (compatible) and eight heterothallic (incompatible) members of the genera Neurospora and Sordaria...
  27. Sriram K, Gopinathan M. A two variable delay model for the circadian rhythm of Neurospora crassa. J Theor Biol. 2004;231:23-38 pubmed
    ..both the variables, is proposed for the circadian oscillations of protein concentrations in the fungal species Neurospora crassa. The dynamical variables chosen are the concentrations of FRQ and WC-1 proteins...
  28. Bouchard P, Lacroix Labonté J, Desjardins G, Lampron P, Lisi V, Lemieux S, et al. Role of SLV in SLI substrate recognition by the Neurospora VS ribozyme. RNA. 2008;14:736-48 pubmed publisher
    ..Our model of the SLI/SLV complex, which is compatible with biochemical data, leads us to propose novel interactions at the loop I/loop V interface. ..
  29. Sood V, Collins R. Identification of the catalytic subdomain of the VS ribozyme and evidence for remarkable sequence tolerance in the active site loop. J Mol Biol. 2002;320:443-54 pubmed
    We show here that the ribozyme domain of the Neurospora VS ribozyme consists of separable upper and lower subdomains...
  30. Tzokov S, Murray I, Grasby J. The role of magnesium ions and 2'-hydroxyl groups in the VS ribozyme-substrate interaction. J Mol Biol. 2002;324:215-26 pubmed
    The minimal substrate of the trans-cleaving Neurospora VS ribozyme has a stem-loop structure and interacts with the ribozyme by RNA tertiary interactions that remain only partially defined...
  31. D Souza A, Sultana S, Maheshwari R. Characterization and prevalence of a circular mitochondrial plasmid in senescence-prone isolates of Neurospora intermedia. Curr Genet. 2005;47:182-93 pubmed publisher
    ..e., irreversible loss of growth and reproductive potential upon subculturing-in Neurospora intermedia strain M1991-60A, collected from Maddur in southern India, showed the presence of plasmid pMaddur1, ..
  32. Villalta C, Jacobson D, Taylor J. Three new phylogenetic and biological Neurospora species: N. hispaniola, N. metzenbergii and N. perkinsii. Mycologia. 2009;101:777-89 pubmed
    The recent recognition of provisional Neurospora phylogenetic species (PS) 1-3 gave us the opportunity to compare genetic isolation, which underlies phylogenetic species recognition (PSR), with reproductive isolation as criteria for ..
  33. Ellison C, Stajich J, Jacobson D, Natvig D, Lapidus A, Foster B, et al. Massive changes in genome architecture accompany the transition to self-fertility in the filamentous fungus Neurospora tetrasperma. Genetics. 2011;189:55-69 pubmed publisher
    A large region of suppressed recombination surrounds the sex-determining locus of the self-fertile fungus Neurospora tetrasperma. This region encompasses nearly one-fifth of the N...
  34. Zhou Z, Liu X, Hu Q, Zhang N, Sun G, Cha J, et al. Suppression of WC-independent frequency transcription by RCO-1 is essential for Neurospora circadian clock. Proc Natl Acad Sci U S A. 2013;110:E4867-74 pubmed publisher
    ..In the Neurospora circadian oscillator, frequency (frq) transcription requires the WHITE COLLAR (WC) complex...
  35. Zamel R, Collins R. Rearrangement of substrate secondary structure facilitates binding to the Neurospora VS ribozyme. J Mol Biol. 2002;324:903-15 pubmed
    The Neurospora VS ribozyme differs from other small, naturally occurring ribozymes in that it recognizes for trans cleavage or ligation a substrate that consists largely of a stem-loop structure...
  36. Dunlap J, Borkovich K, Henn M, Turner G, Sachs M, Glass N, et al. Enabling a community to dissect an organism: overview of the Neurospora functional genomics project. Adv Genet. 2007;57:49-96 pubmed
    A consortium of investigators is engaged in a functional genomics project centered on the filamentous fungus Neurospora, with an eye to opening up the functional genomic analysis of all the filamentous fungi...
  37. Campbell D, Legault P. Nuclear magnetic resonance structure of the Varkud satellite ribozyme stem-loop V RNA and magnesium-ion binding from chemical-shift mapping. Biochemistry. 2005;44:4157-70 pubmed
    An important step in the substrate recognition of the Neurospora Varkud Satellite (VS) ribozyme is the formation of a magnesium-dependent loop/loop interaction between the terminal loops of stem-loops I and V...
  38. Jaikaran D, Smith M, Mehdizadeh R, Olive J, Collins R. An important role of G638 in the cis-cleavage reaction of the Neurospora VS ribozyme revealed by a novel nucleotide analog incorporation method. RNA. 2008;14:938-49 pubmed publisher
    ..Cleavage rate versus pH profiles combined with kinetic solvent isotope experiments indicate an important role for G638 in proton transfer during the rate-limiting step of the cis-cleavage reaction. ..
  39. Deabreu D, Olive J, Collins R. Additional roles of a peripheral loop-loop interaction in the Neurospora VS ribozyme. Nucleic Acids Res. 2011;39:6223-8 pubmed publisher
    ..These data provide evidence that the kissing interaction strongly affects the observed cleavage and ligation rate constants and the cleavage-ligation equilibrium of the ribozyme. ..
  40. Turner E, Jacobson D, Taylor J. Genetic architecture of a reinforced, postmating, reproductive isolation barrier between Neurospora species indicates evolution via natural selection. PLoS Genet. 2011;7:e1002204 pubmed publisher
    ..We show that reinforced postmating isolation markedly increases maternal fitness in the fungus Neurospora crassa, and we detect the evolutionary genetic signature of natural selection by quantitative trait locus (QTL) ..
  41. Dettman J, Jacobson D, Taylor J. A multilocus genealogical approach to phylogenetic species recognition in the model eukaryote Neurospora. Evolution. 2003;57:2703-20 pubmed
    ..in which biological species recognition (BSR) has been most comprehensively applied, the well-studied genus Neurospora. Four independent anonymous nuclear loci were characterized and sequenced from 147 individuals that were ..
  42. Jacobson D. Blocked recombination along the mating-type chromosomes of Neurospora tetrasperma involves both structural heterozygosity and autosomal genes. Genetics. 2005;171:839-43 pubmed
    The Neurospora tetrasperma mating-type chromosomes have been shown to be structurally heterozygous by reciprocal introgression of these chromosomes between N. tetrasperma and N. crassa...
  43. Menkis A, Bastiaans E, Jacobson D, Johannesson H. Phylogenetic and biological species diversity within the Neurospora tetrasperma complex. J Evol Biol. 2009;22:1923-36 pubmed publisher
    ..of this study was to explore the evolutionary history of the morphologically recognized filamentous ascomycete Neurospora tetrasperma, and to reveal the genetic and reproductive relationships among its individuals and populations...
  44. Sun Y, Corcoran P, Menkis A, Whittle C, Andersson S, Johannesson H. Large-scale introgression shapes the evolution of the mating-type chromosomes of the filamentous ascomycete Neurospora tetrasperma. PLoS Genet. 2012;8:e1002820 pubmed publisher
    ..In this study, we present medium coverage genomic data from species of the filamentous ascomycete Neurospora, and we use comparative genomics to investigate the introgression landscape at the genomic level in this model ..
  45. Mann B, Bowman B, Grotelueschen J, Metzenberg R. Nucleotide sequence of pho-4+, encoding a phosphate-repressible phosphate permease of Neurospora crassa. Gene. 1989;83:281-9 pubmed
    The nucleotide (nt) sequence of the Neurospora crassa pho-4+ gene, which encodes a phosphate-repressible phosphate permease, has been determined. The gene specifies a protein of 590 amino acids (aa) and contains two introns...
  46. Lafontaine D, Norman D, Lilley D. Structure, folding and activity of the VS ribozyme: importance of the 2-3-6 helical junction. EMBO J. 2001;20:1415-24 pubmed
  47. He Q, Cha J, He Q, Lee H, Yang Y, Liu Y. CKI and CKII mediate the FREQUENCY-dependent phosphorylation of the WHITE COLLAR complex to close the Neurospora circadian negative feedback loop. Genes Dev. 2006;20:2552-65 pubmed
    The eukaryotic circadian oscillators consist of circadian negative feedback loops. In Neurospora, it was proposed that the FREQUENCY (FRQ) protein promotes the phosphorylation of the WHITE COLLAR (WC) complex, thus inhibiting its activity...
  48. Menkis A, Jacobson D, Gustafsson T, Johannesson H. The mating-type chromosome in the filamentous ascomycete Neurospora tetrasperma represents a model for early evolution of sex chromosomes. PLoS Genet. 2008;4:e1000030 pubmed publisher
    ..genetics, and phylogenetics to study the evolution of the mating-type chromosome in the filamentous ascomycete Neurospora tetrasperma...
  49. Smith M, Collins R. Evidence for proton transfer in the rate-limiting step of a fast-cleaving Varkud satellite ribozyme. Proc Natl Acad Sci U S A. 2007;104:5818-23 pubmed
    ..These results suggest that the RG ribozyme provides a good experimental system to investigate the nature of fast, rate-limiting steps in a ribozyme cleavage reaction. ..
  50. Gabius H, von der Haar F, Cramer F. Evolutionary aspects of accuracy of phenylalanyl-tRNA synthetase. A comparative study with enzymes from Escherichia coli, Saccharomyces cerevisiae, Neurospora crassa, and turkey liver using phenylalanine analogues. Biochemistry. 1983;22:2331-9 pubmed
    The phenylalanyl-tRNA synthetases from Escherichia coli, Saccharomyces cerevisiae, Neurospora crassa, and turkey liver activate a number of phenylalanine analogues (tyrosine, leucine, methionine, p-fluorophenylalanine, beta-phenylserine, ..
  51. Saenz G, Stam J, Jacobson D, Natvig D. Heteroallelism at the het-c locus contributes to sexual dysfunction in outcrossed strains of Neurospora tetrasperma. Fungal Genet Biol. 2001;34:123-9 pubmed
    b>Neurospora tetrasperma is naturally heterokaryotic, with cells possessing haploid nuclei of both a and A mating types. As a result, isolates are self-fertile (pseudohomothallic)...
  52. Geever R, Huiet L, Baum J, Tyler B, Patel V, Rutledge B, et al. DNA sequence, organization and regulation of the qa gene cluster of Neurospora crassa. J Mol Biol. 1989;207:15-34 pubmed
    In Neurospora, five structural and two regulatory genes mediate the initial events in quinate/shikimate metabolism as a carbon source. These genes are clustered in an 18 x 10(3) base-pair region as a contiguous array...
  53. Dettman J, Harbinski F, Taylor J. Ascospore morphology is a poor predictor of the phylogenetic relationships of Neurospora and Gelasinospora. Fungal Genet Biol. 2001;34:49-61 pubmed
    The genera Neurospora and Gelasinospora are conventionally distinguished by differences in ascospore ornamentation, with elevated longitudinal ridges (ribs) separated by depressed grooves (veins) in Neurospora and spherical or oval ..
  54. Dettman J, Taylor J. Mutation and evolution of microsatellite loci in Neurospora. Genetics. 2004;168:1231-48 pubmed
    The patterns of mutation and evolution at 13 microsatellite loci were studied in the filamentous fungal genus Neurospora. First, a detailed investigation was performed on five microsatellite loci by sequencing each microsatellite, ..
  55. Nygren K, Strandberg R, Wallberg A, Nabholz B, Gustafsson T, García D, et al. A comprehensive phylogeny of Neurospora reveals a link between reproductive mode and molecular evolution in fungi. Mol Phylogenet Evol. 2011;59:649-63 pubmed publisher
    The filamentous ascomycete genus Neurospora encompasses taxa with a wide range of reproductive modes...
  56. Germann U, Muller G, Hunziker P, Lerch K. Characterization of two allelic forms of Neurospora crassa laccase. Amino- and carboxyl-terminal processing of a precursor. J Biol Chem. 1988;263:885-96 pubmed
    The complete structures of the laccase genes isolated from two different Neurospora crassa wild-type strains are described. The genes were cloned by screening partial genomic DNA libraries with a nick-translated laccase-specified 1...
  57. Liu Y, He Q, Cheng P. Photoreception in Neurospora: a tale of two White Collar proteins. Cell Mol Life Sci. 2003;60:2131-8 pubmed
    b>Neurospora crassa is the best-understood fungal organism in terms of the mechanism of light responses. All known Neurospora photoresponses are mediated by blue light...
  58. Bhat A, Tamuli R, Kasbekar D. Genetic transformation of Neurospora tetrasperma, demonstration of repeat-induced point mutation (RIP) in self-crosses and a screen for recessive RIP-defective mutants. Genetics. 2004;167:1155-64 pubmed
    The pseudohomothallic fungus Neurospora tetrasperma is naturally resistant to the antibiotic hygromycin...
  59. Rehman S, Shawl A, Verma V, Kour A, Athar M, Andrabi R, et al. An endophytic Neurospora sp. from Nothapodytes foetida producing camptothecin. Prikl Biokhim Mikrobiol. 2008;44:225-31 pubmed
    ..Isolated endophyte (Neurospora crassa) producing camptothecin may become an easily accessible source for the production of precursor anticancer ..
  60. Perkins D. The use of duplication-generating rearrangements for studying heterokaryon incompatibility genes in Neurospora. Genetics. 1975;80:87-105 pubmed
    ..The results how that the duplication method can be used to identify and map additional vegetative incompatibility loci, without the necessity of heterokaryon tests...
  61. Flinders J, Dieckmann T. A pH controlled conformational switch in the cleavage site of the VS ribozyme substrate RNA. J Mol Biol. 2001;308:665-79 pubmed
    The VS ribozyme is a 154 nucleotide sequence found in certain natural strains of Neurospora. The RNA can be divided into a substrate and a catalytic domain...
  62. Turner B, Perkins D, Fairfield A. Neurospora from natural populations: a global study. Fungal Genet Biol. 2001;32:67-92 pubmed
    This is a summary report on samples of conidiating Neurospora species collected over three decades, in many regions around the world, primarily from burned vegetation...
  63. Dunlap J. Proteins in the Neurospora circadian clockworks. J Biol Chem. 2006;281:28489-93 pubmed
  64. Keeping A, Deabreu D, DiBernardo M, Collins R. Gel-based mass spectrometric and computational approaches to the mitochondrial proteome of Neurospora. Fungal Genet Biol. 2011;48:526-36 pubmed publisher
    ..SDS first dimensions and SDS Laemmli or tricine second dimensions to separate the proteins from highly-purified Neurospora mitochondria and sub-mitochondrial fractions (membrane, soluble, protein complexes and ribonucleoproteins)...
  65. Plesofsky N, Brambl R. Glucose metabolism in Neurospora is altered by heat shock and by disruption of HSP30. Biochim Biophys Acta. 1999;1449:73-82 pubmed
    We compared the metabolism of [1-13C]glucose by wild type cells of Neurospora crassa at normal growth temperature and at heat shock temperatures, using nuclear magnetic resonance analysis of cell extracts...
  66. Sood V, Yekta S, Collins R. The contribution of 2'-hydroxyls to the cleavage activity of the Neurospora VS ribozyme. Nucleic Acids Res. 2002;30:1132-8 pubmed
    ..A cluster of important 2'-OHs lining the minor groove of stem-loop I and helix II suggests that these regions of the backbone may play an important role in positioning helices in the active structure of the ribozyme...
  67. Schafmeier T, Káldi K, Diernfellner A, Mohr C, Brunner M. Phosphorylation-dependent maturation of Neurospora circadian clock protein from a nuclear repressor toward a cytoplasmic activator. Genes Dev. 2006;20:297-306 pubmed
    ..is a central component of interconnected negative and positive limbs of feedback loops of the circadian clock of Neurospora. In the negative limb, FRQ inhibits its transcriptional activator White Collar Complex (WCC) and in the positive ..
  68. Pregueiro A, Liu Q, Baker C, Dunlap J, Loros J. The Neurospora checkpoint kinase 2: a regulatory link between the circadian and cell cycles. Science. 2006;313:644-9 pubmed
    The clock gene period-4 (prd-4) in Neurospora was identified by a single allele displaying shortened circadian period and altered temperature compensation...
  69. Campbell D, Bouchard P, Desjardins G, Legault P. NMR structure of varkud satellite ribozyme stem-loop V in the presence of magnesium ions and localization of metal-binding sites. Biochemistry. 2006;45:10591-605 pubmed
    In the Neurospora VS ribozyme, magnesium ions facilitate formation of a loop-loop interaction between stem-loops I and V, which is important for recognition and activation of the stem-loop I substrate...
  70. Saelices L, Youssar L, Holdermann I, Al Babili S, Avalos J. Identification of the gene responsible for torulene cleavage in the Neurospora carotenoid pathway. Mol Genet Genomics. 2007;278:527-37 pubmed
    Torulene, a C(40) carotene, is the precursor of the end product of the Neurospora carotenoid pathway, the C(35) xanthophyll neurosporaxanthin...
  71. Cha J, Huang G, Guo J, Liu Y. Posttranslational control of the Neurospora circadian clock. Cold Spring Harb Symp Quant Biol. 2007;72:185-91 pubmed publisher
    ..Investigations of the Neurospora circadian clock system have elucidated many of the basic mechanisms that underlie circadian rhythms, including ..
  72. Neiss A, Schafmeier T, Brunner M. Transcriptional regulation and function of the Neurospora clock gene white collar 2 and its isoforms. EMBO Rep. 2008;9:788-94 pubmed publisher
    ..WC1 and WC2 subunits, are crucial components of positive and negative feedback loops of the circadian clock of Neurospora. In the positive limb, FRQ supports the accumulation of WC1 on a post-translational level and activates ..
  73. Zhang F, Liu S, Lu X, Guo L, Zhang H, Che Y. Allenyl and alkynyl phenyl ethers from the endolichenic fungus Neurospora terricola. J Nat Prod. 2009;72:1782-5 pubmed publisher
    ..4-6), new alkynyl phenyl ethers, have been isolated from the crude extract of the endolichenic fungus Neurospora terricola. The structures of these compounds were elucidated primarily by NMR experiments...
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    b>Neurospora mitochondrial tyrosyl-tRNA synthetase (mt TyrRS), which is encoded by nuclear gene cyt-18, functions in splicing group I introns...
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    ..of both plasmids exhibit similarity to the reverse transcriptase of the Mauriceville and Varkud plasmids of Neurospora spp...
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    ..NAIM experiments indicate that a protonated base is required at this position for the ligation reaction. A756 is thus a strong candidate for nucleobase participation in the catalytic chemistry...
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    Protein phosphorylation plays essential roles in eukaryotic circadian clocks. Like PERIOD in animals, the Neurospora core circadian protein FRQ is progressively phosphorylated and becomes extensively phosphorylated before its degradation...
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    ..The Neurospora tetrasperma mating-type (mat) chromosomes contain a young (<6 Mya) and large region (>6...
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    ..To distinguish between these two possibilities, we used traditional circadian entrainment protocols on a genetic model system, Neurospora crassa.