leishmania tropica

Summary

Summary: A parasitic hemoflagellate of the subgenus Leishmania leishmania that infects man and rodents. This taxonomic complex includes species which cause a disease called Oriental sore which is a form of cutaneous leishmaniasis (LEISHMANIASIS, CUTANEOUS) of the Old World.

Top Publications

  1. Yaghoobi Ershadi M, Hanafi Bojd A, Javadian E, Jafari R, Zahraei Ramazani A, Mohebali M. A new focus of cutaneous leishmaniasis caused by Leishmania tropica. Saudi Med J. 2002;23:291-4 pubmed
    ..To determine the epidemiological status of the cutaneous leishmaniasis outbreak, isolation and identification of the parasite and preparation of a control program in a recently identified focus located in the Province of Yazd, Central Iran...
  2. Azmi K, Schonian G, Schnur L, Nasereddin A, Ereqat S, Abdeen Z. Development of assays using hexokinase and phosphoglucomutase gene sequences that distinguish strains of Leishmania tropica from different zymodemes and microsatellite clusters and their application to Palestinian foci of cutaneous leishmaniasis. PLoS Negl Trop Dis. 2013;7:e2464 pubmed publisher
    ..Both assays proved useful for identifying leishmanial parasites in clinical samples without resource to culture and MLEE. ..
  3. Mahmoudzadeh Niknam H, Khalili G, Abrishami F, Najafy A, Khaze V. The route of Leishmania tropica infection determines disease outcome and protection against Leishmania major in BALB/c mice. Korean J Parasitol. 2013;51:69-74 pubmed publisher
    b>Leishmania tropica is one of the causative agents of leishmaniasis in humans. Routes of infection have been reported to be an important variable for some species of Leishmania parasites. The role of this variable is not clear for L...
  4. Yahia H, Ready P, Hamdani A, Testa J, Guessous Idrissi N. Regional genetic differentiation of Phlebotomus sergenti in three Moroccan foci of cutaneous leishmaniasis caused by Leishmania tropica. Parasite. 2004;11:189-99 pubmed
    ..sergenti was identified morphologically in samples from three Moroccan foci of leishmaniasis caused by Leishmania tropica in the provinces of Azilal, Essaouira and Taza...
  5. Anders G, Eisenberger C, Jonas F, Greenblatt C. Distinguishing Leishmania tropica and Leishmania major in the Middle East using the polymerase chain reaction with kinetoplast DNA-specific primers. Trans R Soc Trop Med Hyg. 2002;96 Suppl 1:S87-92 pubmed
    ..Due to species-specific differences in the size of minicircles, these primers can be used in the polymerase chain reaction to answer diagnostic and epidemiological questions. ..
  6. Kazemi Rad E, Mohebali M, Khadem Erfan M, Hajjaran H, Hadighi R, Khamesipour A, et al. Overexpression of ubiquitin and amino acid permease genes in association with antimony resistance in Leishmania tropica field isolates. Korean J Parasitol. 2013;51:413-9 pubmed publisher
    ..This study aimed to recognize genes involved in antimony resistance of Leishmania tropica field isolates. Sensitive and resistant L...
  7. Svobodova M, Votypka J, Peckova J, Dvorák V, Nasereddin A, Baneth G, et al. Distinct transmission cycles of Leishmania tropica in 2 adjacent foci, Northern Israel. Emerg Infect Dis. 2006;12:1860-8 pubmed
    Transmission of Leishmania tropica was studied in 2 adjacent foci in Israel where vector populations differ. Only Phlebotomus sergenti was found infected with L. tropica in the southern focus; P...
  8. Goswami S, Adhya S. The alpha-subunit of Leishmania F1 ATP synthase hydrolyzes ATP in presence of tRNA. J Biol Chem. 2006;281:18914-7 pubmed
    ..The ATPase activity of the intact complex was inhibited by anti-RIC1 antibody, while knockdown of RIC1 in Leishmania tropica resulted in deficiency of the tRNA-dependent ATPase activity of the mitochondrial inner membrane...
  9. Kravchenko V, Wasserberg G, Warburg A. Bionomics of phlebotomine sandflies in the Galilee focus of cutaneous leishmaniasis in northern Israel. Med Vet Entomol. 2004;18:418-28 pubmed
    ..years (2001-2003) in the Galilee focus of cutaneous leishmaniasis in northern Israel, where the causative Leishmania tropica (Kinetoplastida: Trypanosomatidae) is transmitted by Phlebotomus (Adlerius) arabicus Theodor and Phlebotomus ..

More Information

Publications82

  1. Talmi Frank D, Kedem Vaanunu N, King R, Bar Gal G, Edery N, Jaffe C, et al. Leishmania tropica infection in golden jackals and red foxes, Israel. Emerg Infect Dis. 2010;16:1973-5 pubmed publisher
    ..of wild canids, internal transcribed spacer 1 real-time PCR and high-resolution melt analysis identified Leishmania tropica in samples from jackals and foxes. Infection was most prevalent in ear and spleen samples...
  2. Oshaghi M, Rasolian M, Shirzadi M, Mohtarami F, Doosti S. First report on isolation of Leishmania tropica from sandflies of a classical urban Cutaneous leishmaniasis focus in southern Iran. Exp Parasitol. 2010;126:445-50 pubmed publisher
    ..of Cutaneous leishmaniasis (CL) and previous research has consistently documented the etiologic agent to be Leishmania tropica and Leishmania major in urban and rural areas, respectively...
  3. Jacobson R. Leishmania tropica (Kinetoplastida: Trypanosomatidae)--a perplexing parasite. Folia Parasitol (Praha). 2003;50:241-50 pubmed
    b>Leishmania tropica is one of the causative agents of cutaneous leishmaniasis (CL), a disfiguring parasitic disease that recently was found to be viscerotropic...
  4. Basu S, Mukherjee S, Adhya S. Proton-guided movements of tRNA within the Leishmania mitochondrial RNA import complex. Nucleic Acids Res. 2008;36:1599-609 pubmed publisher
    The RNA import complex (RIC) from the mitochondrion of the kinetoplastid protozoan Leishmania tropica contains two subunits that directly bind to import signals on two distinct subsets of tRNA and interact with each other allosterically...
  5. Shirian S, Oryan A, Hatam G, Daneshbod Y. Mixed mucosal leishmaniasis infection caused by Leishmania tropica and Leishmania major. J Clin Microbiol. 2012;50:3805-8 pubmed publisher
    ..leishmaniasis (ML), a patient with both oral and nasal lesions was found to be concomitantly infected with Leishmania tropica and L. major...
  6. Schnur L, Nasereddin A, Eisenberger C, Jaffe C, El Fari M, Azmi K, et al. Multifarious characterization of leishmania tropica from a Judean desert focus, exposing intraspecific diversity and incriminating phlebotomus sergenti as its vector. Am J Trop Med Hyg. 2004;70:364-72 pubmed
    ..Leishmania isolates from Ph. sergenti and humans typed as Leishmania tropica. Sand fly and human isolates produced similar small nodular cutaneous lesions in hamsters...
  7. Bhattacharyya S, Chatterjee S, Adhya S. Mitochondrial RNA import in Leishmania tropica: aptamers homologous to multiple tRNA domains that interact cooperatively or antagonistically at the inner membrane. Mol Cell Biol. 2002;22:4372-82 pubmed
  8. Duran G, Duran N, Culha G, Ozcan B, Oztas H, Ozer B. In vitro antileishmanial activity of Adana propolis samples on Leishmania tropica: a preliminary study. Parasitol Res. 2008;102:1217-25 pubmed publisher
    ..aimed to investigate the in vitro effects of an ethanolic extract of Adana propolis samples on the growth of Leishmania tropica. Parasite cells were treated with five concentrations (25, 50, 100, 50, 500, and 750 microg/ml) of the ..
  9. Schwenkenbecher J, Wirth T, Schnur L, Jaffe C, Schallig H, Al Jawabreh A, et al. Microsatellite analysis reveals genetic structure of Leishmania tropica. Int J Parasitol. 2006;36:237-46 pubmed
    The current rapid spread of leishmaniases caused by Leishmania tropica and the complexity of its clinical spectrum call for this parasite's epidemiological and evolutionary investigation...
  10. Kazemi Rad E, Mohebali M, Khadem Erfan M, Saffari M, Raoofian R, Hajjaran H, et al. Identification of antimony resistance markers in Leishmania tropica field isolates through a cDNA-AFLP approach. Exp Parasitol. 2013;135:344-9 pubmed publisher
    ..used a cDNA-AFLP approach to identify gene(s) which are differentially expressed in resistant and sensitive Leishmania tropica field isolates...
  11. Alborzi A, Pouladfar G, Fakhar M, Motazedian M, Hatam G, Kadivar M. Isolation of Leishmania tropica from a patient with visceral leishmaniasis and disseminated cutaneous leishmaniasis, southern Iran. Am J Trop Med Hyg. 2008;79:435-7 pubmed
    We report a case visceral leishmaniasis with disseminated cutaneous leishmaniasis caused by Leishmania tropica in southern Iran...
  12. Hadighi R, Mohebali M, Boucher P, Hajjaran H, Khamesipour A, Ouellette M. Unresponsiveness to Glucantime treatment in Iranian cutaneous leishmaniasis due to drug-resistant Leishmania tropica parasites. PLoS Med. 2006;3:e162 pubmed
    ..This study was designed to determine whether the clinical responses (healing, or non-healing) were correlated with the susceptibility of Leishmania parasites to Glucantime...
  13. Jirku M, Zemanova E, Al Jawabreh A, Schonian G, Lukes J. Development of a direct species-specific PCR assay for differential diagnosis of Leishmania tropica. Diagn Microbiol Infect Dis. 2006;55:75-9 pubmed
    We have developed a polymerase chain reaction assay for differential diagnosis of Leishmania tropica, based on simple amplification of the target region...
  14. Talmi Frank D, Jaffe C, Nasereddin A, Warburg A, King R, Svobodova M, et al. Leishmania tropica in rock hyraxes (Procavia capensis) in a focus of human cutaneous leishmaniasis. Am J Trop Med Hyg. 2010;82:814-8 pubmed publisher
    Cutaneous leishmaniasis, caused by Leishmania tropica, has recently emerged in urban and rural foci of central and northern Israel, and constitutes a major public health concern...
  15. Perez Victoria J, Pérez Victoria F, Parodi Talice A, Jimenez I, Ravelo A, Castanys S, et al. Alkyl-lysophospholipid resistance in multidrug-resistant Leishmania tropica and chemosensitization by a novel P-glycoprotein-like transporter modulator. Antimicrob Agents Chemother. 2001;45:2468-74 pubmed
    ..i) First, a multidrug resistance (MDR) Leishmania tropica line overexpressing a P-glycoprotein-like transporter displays significant cross-resistance to the ALP ..
  16. Kumar R, Bumb R, Salotra P. Evaluation of localized and systemic immune responses in cutaneous leishmaniasis caused by Leishmania tropica: interleukin-8, monocyte chemotactic protein-1 and nitric oxide are major regulatory factors. Immunology. 2010;130:193-201 pubmed publisher
    We have established Leishmania tropica as the causative agent of cutaneous leishmaniasis (CL) in the region of India where the disease is endemic...
  17. Saliba E, Pratlong F, Dedet J, Saleh N, Khoury S, Oumeish O, et al. Identification of Leishmania strains from Jordan. Ann Trop Med Parasitol. 2004;98:677-83 pubmed
    ..e. isocitrate dehydrogenase and glucose phosphate isomerase), confirming the high level of enzymatic polymorphism of L. tropica. So far, MON-200 and MON-265 have only been found in Jordan...
  18. Mukherjee S, Basu S, Home P, Dhar G, Adhya S. Necessary and sufficient factors for the import of transfer RNA into the kinetoplast mitochondrion. EMBO Rep. 2007;8:589-95 pubmed
    ..Factors mediating the import of tRNA into the kinetoplast mitochondrion of the protozoon Leishmania tropica are organized into a multiprotein RNA import complex (RIC) at the inner membrane...
  19. Rhajaoui M, Fellah H, Pratlong F, Dedet J, Lyagoubi M. Leishmaniasis due to Leishmania tropica MON-102 in a new Moroccan focus. Trans R Soc Trop Med Hyg. 2004;98:299-301 pubmed
    ..Among 95 cases, 76 were positive by direct observation of Giemsa-stained smears. Sixteen stocks were isolated in NNN medium and identified as Leishmania tropica MON-102, using isoenzyme techniques on starch gel electrophoresis.
  20. Svobodova M, Votypka J. Experimental transmission of Leishmania tropica to hamsters and mice by the bite of Phlebotomus sergenti. Microbes Infect. 2003;5:471-4 pubmed
    Phlebotomus sergenti is a natural vector of Leishmania tropica. However, the ability of P. sergenti to transmit L. tropica by bite has not been proven experimentally yet. We have transmitted L...
  21. Svobodova M, Volf P, Votypka J. Experimental transmission of Leishmania tropica to hyraxes (Procavia capensis) by the bite of Phlebotomus arabicus. Microbes Infect. 2006;8:1691-4 pubmed
    The ability of the sand fly Phlebotomus (Adlerius) arabicus to transmit Leishmania tropica was studied experimentally using hyraxes (Procavia capensis), natural reservoir hosts of the parasite. Sand flies became infected with L...
  22. Hadighi R, Boucher P, Khamesipour A, Meamar A, Roy G, Ouellette M, et al. Glucantime-resistant Leishmania tropica isolated from Iranian patients with cutaneous leishmaniasis are sensitive to alternative antileishmania drugs. Parasitol Res. 2007;101:1319-22 pubmed
    ..SbV) based drug Glucantime is the first line of treatment for CL in Iran, but recently SbV-resistant Leishmania tropica isolates derived from unresponsive patients were reported...
  23. Allahverdiyev A, Koc R, Ateş S, Bagirova M, Elçıçek S, Oztel O. Leishmania tropica: the effect of darkness and light on biological activities in vitro. Exp Parasitol. 2011;128:318-23 pubmed publisher
    ..The aim of this study is to investigate the effects of light on various cell parameters of Leishmania tropica, in vitro. All experiments were conducted on L...
  24. Anderson C, Lira R, Kamhawi S, Belkaid Y, Wynn T, Sacks D. IL-10 and TGF-beta control the establishment of persistent and transmissible infections produced by Leishmania tropica in C57BL/6 mice. J Immunol. 2008;180:4090-7 pubmed
    b>Leishmania tropica is the causative agent of Old World anthroponotic cutaneous leishmaniasis, which is characterized by lesions that take an extended period of time to heal, often resulting in disfiguring scars, and are more refractory to ..
  25. Rhajaoui M, Nasereddin A, Fellah H, Azmi K, Amarir F, Al Jawabreh A, et al. New clinico-epidemiologic profile of cutaneous leishmaniasis, Morocco. Emerg Infect Dis. 2007;13:1358-60 pubmed publisher
    ..We describe distribution of Leishmania major and L. tropica in Morocco and a new focus of cutaneous leishmaniasis due to L. infantum. We recommend using molecular techniques to diagnose suspected leishmaniasis cases...
  26. Al Mulla Hummadi Y, Al Bashir N, Najim R. Leishmania major and Leishmania tropica: II. Effect of an immunomodulator, S(2) complex on the enzymes of the parasites. Exp Parasitol. 2006;112:85-91 pubmed
    ..Thus, the direct antileishmanial effect of S(2) complex may result, partially or entirely, from the inhibition of enzymes that are necessary for the parasites' carbohydrate metabolism...
  27. Shani Adir A, Kamil S, Rozenman D, Schwartz E, Ramon M, Zalman L, et al. Leishmania tropica in northern Israel: a clinical overview of an emerging focus. J Am Acad Dermatol. 2005;53:810-5 pubmed
    In Israel, most cutaneous leishmaniasis (CL) is caused by Leishmania major. Recently a new focus of CL caused by Leishmania tropica has been described in Tiberias and the surrounding area of northern Israel.
  28. Soares R, Barron T, McCoy Simandle K, Svobodova M, Warburg A, Turco S. Leishmania tropica: intraspecific polymorphisms in lipophosphoglycan correlate with transmission by different Phlebotomus species. Exp Parasitol. 2004;107:105-14 pubmed
    ..To provide additional evidence for its importance in transmission, the LPGs from three Leishmania tropica strains that differ in their capability to infect sand flies, were biochemically characterized...
  29. Greenblatt C, Schnur L, Bar Gal G, Ermolaev H, Peleg N, Barrett M. Polymorphism among alleles of the 6-phosphogluconate dehydrogenase gene from Leishmania major and Leishmania tropica. Mol Biochem Parasitol. 2002;125:185-8 pubmed
  30. Girginkardeşler N, Balcioglu I, Yereli K, Ozbilgin A, Ozbel Y. Cutaneous leishmaniasis infection in Balb/c mice using a Leishmania tropica strain isolated from Turkey. J Parasitol. 2001;87:1177-8 pubmed
    b>Leishmania tropica, which is endemic in Turkey, is the causative agent of cutaneous leishmaniasis...
  31. Rab M, al Rustamani L, Bhutta R, Mahmood M, Evans D. Cutaneous leishmaniasis: iso-enzyme characterisation of Leishmania tropica. J Pak Med Assoc. 1997;47:270-3 pubmed
    ..The study confirms the presence of anthroponotic Cutaneous Leishamaniasis caused by L. Tropica in Pakistan...
  32. Reithinger R, Mohsen M, Aadil K, Sidiqi M, Erasmus P, Coleman P. Anthroponotic cutaneous leishmaniasis, Kabul, Afghanistan. Emerg Infect Dis. 2003;9:727-9 pubmed
    ..Incidence of disease was estimated to be 2.9% (29 cases/1,000 persons per year; 95% confidence interval 0.018 to 0.031). Disease was associated with age and gender; logistic regression analyses showed significant clustering of cases...
  33. Kivcak B, Mert T, Ertabaklar H, Balcioglu I, Ozensoy Toz S. In vitro activity of Arbutus unedo against Leishmania tropica promastigotes. Turkiye Parazitol Derg. 2009;33:114-5 pubmed
    ..water and n-hexane extracts from the leaves of Arbutus unedo were originally tested in vitro against Leishmania tropica promastigotes...
  34. Bousslimi N, Ben Ayed S, Ben Abda I, Aoun K, Bouratbine A. Natural infection of North African gundi (Ctenodactylus gundi) by Leishmania tropica in the focus of cutaneous leishmaniasis, Southeast Tunisia. Am J Trop Med Hyg. 2012;86:962-5 pubmed publisher
    ..Real-time PCR on blood was positive in 6 of 13 (46.2%) tested gundis. Leishmania tropica was identified in five infected gundis and Leishmania major in one specimen...
  35. Rosypal A, Werbovetz K, Salem M, Stephens C, Kumar A, Boykin D, et al. Inhibition by Dications of in vitro growth of Leishmania major and Leishmania tropica: causative agents of old world cutaneous leishmaniasis. J Parasitol. 2008;94:743-9 pubmed publisher
    Old World cutaneous leishmaniasis is caused by infection with Leishmania major and Leishmania tropica. Pentamidine and related dications exhibit broad spectrum antiprotozoal activity...
  36. Stefanidou M, Antoniou M, Koutsopoulos A, Neofytou Y, Krasagakis K, Kruger Krasagakis S, et al. A rare case of leishmaniasis recidiva cutis evolving for 31 years caused by Leishmania tropica. Int J Dermatol. 2008;47:588-9 pubmed publisher
    ..A few Leishmania organisms were found on careful searching (Fig. 2). Leishmania tropica was identified by culture and PCR...
  37. Gebre Michael T, Balkew M, Ali A, Ludovisi A, Gramiccia M. The isolation of Leishmania tropica and L. aethiopica from Phlebotomus (Paraphlebotomus) species (Diptera: Psychodidae) in the Awash Valley, northeastern Ethiopia. Trans R Soc Trop Med Hyg. 2004;98:64-70 pubmed
    ..The possible presence of human cutaneous leishmaniasis (L. tropica and L. aethiopica), and wild reservoir host(s) of the parasites, especially rock hyrax (Procavia capensis) in the Upper and Middle Awash Valley remain to be determined...
  38. Faulde M, Schrader J, Heyl G, Amirih M. Differences in transmission seasons as an epidemiological tool for characterization of anthroponotic and zoonotic cutaneous leishmaniasis in northern Afghanistan. Acta Trop. 2008;105:131-8 pubmed
  39. Schwenkenbecher J, Fröhlich C, Gehre F, Schnur L, Schonian G. Evolution and conservation of microsatellite markers for Leishmania tropica. Infect Genet Evol. 2004;4:99-105 pubmed
    Sixteen polymorphic microsatellite markers were developed for phylogenetic analysis of Leishmania tropica. The phylogenetic tests done demonstrated that they do provide a powerful tool for epidemiological studies...
  40. Mahmoudzadeh Niknam H, McKerrow J. Leishmania tropica: cysteine proteases are essential for growth and pathogenicity. Exp Parasitol. 2004;106:158-63 pubmed
    ..Here, we establish a key role of cysteine proteases in growth, viability, and pathogenicity of Leishmania tropica by using a specific cysteine protease inhibitor (N-Pip-F-hF-VS Phenyl)...
  41. Ashford R, Kohestany K, Karimzad M. Cutaneous leishmaniasis in Kabul: observations on a 'prolonged epidemic'. Ann Trop Med Parasitol. 1992;86:361-71 pubmed
    ..It is suggested that Leishmania tropica is at the limit of its range in Kabul and only remains endemic because of the rapid turnover of people in ..
  42. Chatterjee S, Home P, Mukherjee S, Mahata B, Goswami S, Dhar G, et al. An RNA-binding respiratory component mediates import of type II tRNAs into Leishmania mitochondria. J Biol Chem. 2006;281:25270-7 pubmed
  43. Bousslimi N, Aoun K, Ben Abda I, Ben Alaya Bouafif N, Raouane M, Bouratbine A. Epidemiologic and clinical features of cutaneous leishmaniasis in southeastern Tunisia. Am J Trop Med Hyg. 2010;83:1034-9 pubmed publisher
    ..b>Leishmania tropica and L. major were identified in 31 (47%) and 35 (53%) cases respectively...
  44. Schonian G, Schnur L, El Fari M, Oskam L, Kolesnikov A, Sokolowska Kohler W, et al. Genetic heterogeneity in the species Leishmania tropica revealed by different PCR-based methods. Trans R Soc Trop Med Hyg. 2001;95:217-24 pubmed
    ..amplified ribosomal internal transcribed spacer, were used to investigate genetic variability in the species Leishmania tropica. Twenty-nine strains of the 'L...
  45. Saliba E, Disi A, Ayed R, Saleh N, al Younes H, Oumeish O, et al. Rodents as reservoir hosts of cutaneous leishmaniasis in Jordan. Ann Trop Med Parasitol. 1994;88:617-22 pubmed
    ..crassus, M. tristrami, Allactaga euphratica and Gerbillus spp.) yielded Leishmania parasites, confirming that P. obesus is the major reservoir host of cutaneous leishmaniasis in Jordan...
  46. Solomon M, Pavlotsky F, Leshem E, Ephros M, Trau H, Schwartz E. Liposomal amphotericin B treatment of cutaneous leishmaniasis due to Leishmania tropica. J Eur Acad Dermatol Venereol. 2011;25:973-7 pubmed publisher
    ..Over the last decade or so, an increase in Leishmania tropica (L. tropica) infections has occurred in several regions of Israel...
  47. Svobodova M, Votypka J, Nicolas L, Volf P. Leishmania tropica in the black rat (Rattus rattus): persistence and transmission from asymptomatic host to sand fly vector Phlebotomus sergenti. Microbes Infect. 2003;5:361-4 pubmed
    Black rats (Rattus rattus) receiving Leishmania tropica injected intradermally into the ear were studied for the persistence of parasites and infectivity to natural sand fly vector...
  48. Mihoubi I, Picot S, Hafirassou N, de Monbrison F. Cutaneous leishmaniasis caused by Leishmania tropica in Algeria. Trans R Soc Trop Med Hyg. 2008;102:1157-9 pubmed publisher
    ..Surprisingly, Leishmania tropica was detected in 6/69 patients, and confirmation was obtained by sequencing...
  49. Alborzi A, Rasouli M, Shamsizadeh A. Leishmania tropica-isolated patient with visceral leishmaniasis in southern Iran. Am J Trop Med Hyg. 2006;74:306-7 pubmed
    ..tropica was also detected. VL mostly involves children below 2 years of age in Iran, therefore infection with L. infantum was expected, but this study is the first report of VL that is caused by L. tropica in Iran...
  50. Mirande M. The ins and outs of tRNA transport. EMBO Rep. 2007;8:547-9 pubmed
  51. Meymandi S, Dabiri S, Dabiri D, Crawford R, Kharazmi A. A quantitative study of epidermal Langerhans cells in cutaneous leishmaniasis caused by Leishmania tropica. Int J Dermatol. 2004;43:819-23 pubmed
    ..The purpose of this study was to characterize the number and distribution of epidermal Langerhans cells in different clinical forms of dry-type cutaneous leishmaniasis (CL)...
  52. Goswami S, Dhar G, Mukherjee S, Mahata B, Chatterjee S, Home P, et al. A bifunctional tRNA import receptor from Leishmania mitochondria. Proc Natl Acad Sci U S A. 2006;103:8354-9 pubmed
    ..The inner membrane RNA import complex of Leishmania tropica contains multiple proteins and is active for import in vitro...
  53. Kobets T, Havelková H, Grekov I, Volkova V, Vojtísková J, Slapnicková M, et al. Genetics of host response to Leishmania tropica in mice - different control of skin pathology, chemokine reaction, and invasion into spleen and liver. PLoS Negl Trop Dis. 2012;6:e1667 pubmed publisher
    Leishmaniasis is a disease caused by protozoan parasites of genus Leishmania. The frequent involvement of Leishmania tropica in human leishmaniasis has been recognized only recently. Similarly as L. major, L...
  54. Azmi K, Schonian G, Nasereddin A, Schnur L, Sawalha S, Hamarsheh O, et al. Epidemiological and clinical features of cutaneous leishmaniases in Jenin District, Palestine, including characterisation of the causative agents in clinical samples. Trans R Soc Trop Med Hyg. 2012;106:554-62 pubmed publisher
    ..6%) were Leishmania tropica and 3 (6.4%) were L. major...
  55. Tabbabi A, Ghrab J, Aoun K, Ready P, Bouratbine A. Habitats of the sandfly vectors of Leishmania tropica and L. major in a mixed focus of cutaneous leishmaniasis in southeast Tunisia. Acta Trop. 2011;119:131-7 pubmed publisher
    ..Tataouine governorate, southeast Tunisia, a mixed focus of human cutaneous leishmaniasis caused by Leishmania tropica and Leishmania major...
  56. Hanafi H, El Din E, El Hossary S, Kaldas R, Villinski J, Furman B, et al. Experimental acquisition, development, and transmission of Leishmania tropica by Phlebotomus duboscqi. Acta Trop. 2013;125:37-42 pubmed publisher
    We report experimental infection and transmission of Leishmania tropica (Wright), by the blood-feeding sand fly Phlebotomus duboscqi (Neveu-Lemaire). Groups of laboratory-reared female sand flies that fed "naturally" on L...
  57. Kumar R, Bumb R, Ansari N, Mehta R, Salotra P. Cutaneous leishmaniasis caused by Leishmania tropica in Bikaner, India: parasite identification and characterization using molecular and immunologic tools. Am J Trop Med Hyg. 2007;76:896-901 pubmed
    ..3% (25/28). Except for the kDNA PCR, all other assays were 100% specific. This study provides the first comprehensive molecular and immunologic studies of CL in India...
  58. Mahmoudzadeh Niknam H, Kiaei S, Iravani D. Protective immunity against Leishmania major induced by Leishmania tropica infection of BALB/c mice. Exp Parasitol. 2011;127:448-53 pubmed publisher
    ..tropica infection in the studied intervals...
  59. Berens Riha N, Fleischmann E, Pratlong F, Bretzel G, von Sonnenburg F, Loscher T. Cutaneous leishmaniasis (Leishmania tropica) in a German tourist after travel to Greece. J Travel Med. 2009;16:220-2 pubmed publisher
    ..Greece with cutaneous leishmaniasis (CL) presenting as multiple erythematosquamous lesions caused by Leishmania tropica (zymodeme MON-57)...
  60. Bensoussan E, Nasereddin A, Jonas F, Schnur L, Jaffe C. Comparison of PCR assays for diagnosis of cutaneous leishmaniasis. J Clin Microbiol. 2006;44:1435-9 pubmed
    ..6% of the positive samples, which included strains of Leishmania major (50.9%), Leishmania tropica (47.2%), and the Leishmania braziliensis complex (1.9%)...
  61. Sharma N, Mahajan V, Kanga A, Sood A, Katoch V, Mauricio I, et al. Localized cutaneous leishmaniasis due to Leishmania donovani and Leishmania tropica: preliminary findings of the study of 161 new cases from a new endemic focus in himachal pradesh, India. Am J Trop Med Hyg. 2005;72:819-24 pubmed
    Localized cutaneous leishmaniasis (LCL) in India is due mostly to Leishmania tropica. It is mainly endemic in the deserts of Rajasthan. Recently, Himachal Pradesh has been identified as a new endemic focus for the disease...
  62. Reithinger R, Aadil K, Hami S, Kolaczinski J. Cutaneous leishmaniasis, northern Afghanistan. Emerg Infect Dis. 2004;10:966-7 pubmed
  63. Depaquit J, Ferté H, Léger N, Lefranc F, Alves Pires C, Hanafi H, et al. ITS 2 sequences heterogeneity in Phlebotomus sergenti and Phlebotomus similis (Diptera, Psychodidae): possible consequences in their ability to transmit Leishmania tropica. Int J Parasitol. 2002;32:1123-31 pubmed
    An intraspecific study on Phlebotomus sergenti, the main and only proven vector of Leishmania tropica among the members of the subgenus Paraphlebotomus was performed...
  64. Dvorak V, Votypka J, Aytekin A, Alten B, Volf P. Intraspecific variability of natural populations of Phlebotomus sergenti, the main vector of Leishmania tropica. J Vector Ecol. 2011;36 Suppl 1:S49-57 pubmed publisher
    ..A previously postulated hypothesis about a complex of sibling species within P. sergenti is therefore questionable. Cytochrome B seems to be a more discriminative marker for intraspecific variability assessment...
  65. Shokri A, Sharifi I, Khamesipour A, Nakhaee N, Fasihi Harandi M, Nosratabadi J, et al. The effect of verapamil on in vitro susceptibility of promastigote and amastigote stages of Leishmania tropica to meglumine antimoniate. Parasitol Res. 2012;110:1113-7 pubmed publisher
    ..present study, the effect of verapamil on in vitro susceptibility of promastigote and amastigote stages of Leishmania tropica to meglumine antimoniate (MA, Glucantime) was evaluated using colorimetric assay (MTT) and in a macrophage ..
  66. Talmi Frank D, Jaffe C, Nasereddin A, Baneth G. Leishmania tropica experimental infection in the rat using luciferase-transfected parasites. Vet Parasitol. 2012;187:57-62 pubmed publisher
    b>Leishmania tropica is the causative agent of zoonotic cutaneous leishmaniasis in different parts of the Old World...
  67. Hajjaran H, Azarian B, Mohebali M, Hadighi R, Assareh A, Vaziri B. Comparative proteomics study on meglumine antimoniate sensitive and resistant Leishmania tropica isolated from Iranian anthroponotic cutaneous leishmaniasis patients. East Mediterr Health J. 2012;18:165-71 pubmed
    ..leishmaniasis (CL), we performed a comparative proteomics analysis on sensitive and resistant strains of Leishmania tropica isolated from Iranian CL patients...
  68. Shehata M, Samy A, Doha S, Fahmy A, Kaldas R, Furman B, et al. First report of Leishmania tropica from a classical focus of L. major in North-Sinai, Egypt. Am J Trop Med Hyg. 2009;81:213-8 pubmed
    ..We report the first isolation of Leishmania tropica from human cases of CL in a Northern Sinai community bordering Palestine...
  69. Azmi K, Schnur L, Schonian G, Nasereddin A, Pratlong F, El Baidouri F, et al. Genetic, serological and biochemical characterization of Leishmania tropica from foci in northern Palestine and discovery of zymodeme MON-307. Parasit Vectors. 2012;5:121 pubmed publisher
    ..Many cases of cutaneous leishmaniasis (CL) have been recorded in the Jenin District based on their clinical appearance. Here, their parasites have been characterized in depth...
  70. Hailu A, Di Muccio T, Abebe T, Hunegnaw M, Kager P, Gramiccia M. Isolation of Leishmania tropica from an Ethiopian cutaneous leishmaniasis patient. Trans R Soc Trop Med Hyg. 2006;100:53-8 pubmed
    ..tropica zymodeme MON-71, one of the new zymodemes found in Ethiopia from P. sergenti in the same region so far. The epidemiological implications of the finding are discussed...
  71. Mahmoudzadeh Niknam H, Kiaei S, Iravani D. Leishmania tropica infection, in comparison to Leishmania major, induces lower delayed type hypersensitivity in BALB/c mice. Korean J Parasitol. 2007;45:103-9 pubmed
    b>Leishmania tropica and L. major are etiologic agents of human cutaneous leishmaniasis...
  72. Kennedy M, Cortés Selva F, Perez Victoria J, Jimenez I, Gonzalez A, Muñoz O, et al. Chemosensitization of a multidrug-resistant Leishmania tropica line by new sesquiterpenes from Maytenus magellanica and Maytenus chubutensis. J Med Chem. 2001;44:4668-76 pubmed
    ..Fourteen compounds, 1-3 and 6-16, have been tested on a multidrug-resistant Leishmania tropica line overexpressing a P-glycoprotein-like transporter to determine their ability to revert the resistance ..
  73. Katara G, Raj A, Kumar R, Avishek K, Kaushal H, Ansari N, et al. Analysis of localized immune responses reveals presence of Th17 and Treg cells in cutaneous leishmaniasis due to Leishmania tropica. BMC Immunol. 2013;14:52 pubmed publisher
    ..tropica infection. Expression of selected molecules was evaluated by real time PCR in dermal lesion tissues at pre- and post treatment stages. Plasma IL-17 level was estimated by sandwich ELISA...