leishmania infantum

Summary

Summary: A parasitic hemoflagellate of the subgenus Leishmania leishmania that infects man and animals and causes visceral leishmaniasis (LEISHMANIASIS, VISCERAL). Human infections are confined almost entirely to children. This parasite is commonly seen in dogs, other Canidae, and porcupines with humans considered only an accidental host. Transmission is by Phlebotomus sandflies.

Top Publications

  1. Miró G, Gálvez R, Fraile C, Descalzo M, Molina R. Infectivity to Phlebotomus perniciosus of dogs naturally parasitized with Leishmania infantum after different treatments. Parasit Vectors. 2011;4:52 pubmed publisher
    ..through direct xenodiagnosis the infectivity to Phlebotomus perniciosus of dogs naturally parasitized with Leishmania infantum after treatment, and to follow the clinical and parasite course of disease...
  2. Menezes Souza D, Correa Oliveira R, Guerra Sa R, Giunchetti R, Teixeira Carvalho A, Martins Filho O, et al. Cytokine and transcription factor profiles in the skin of dogs naturally infected by Leishmania (Leishmania) chagasi presenting distinct cutaneous parasite density and clinical status. Vet Parasitol. 2011;177:39-49 pubmed publisher
  3. Cunha J, Carrillo E, Sanchez C, Cruz I, Moreno J, Cordeiro da Silva A. Characterization of the biology and infectivity of Leishmania infantum viscerotropic and dermotropic strains isolated from HIV+ and HIV- patients in the murine model of visceral leishmaniasis. Parasit Vectors. 2013;6:122 pubmed publisher
    ..This work is supported by other studies that present the parasite's inherent features as factors for the multiplicity of clinical manifestations and severity of leishmaniasis. ..
  4. Michel G, Pomares C, Ferrua B, Marty P. Importance of worldwide asymptomatic carriers of Leishmania infantum (L. chagasi) in human. Acta Trop. 2011;119:69-75 pubmed publisher
    Leishmaniasis due to Leishmania infantum (syn. L. chagasi) infection is a zoonotic disease present mainly in Mediterranean basin, central Asia and Brazil...
  5. Lombardo G, Pennisi M, Lupo T, Migliazzo A, Caprì A, Solano Gallego L. Detection of Leishmania infantum DNA by real-time PCR in canine oral and conjunctival swabs and comparison with other diagnostic techniques. Vet Parasitol. 2012;184:10-7 pubmed publisher
    ..One hundred sixty-three dogs living outdoor and recruited in various provinces of Sicily were studied. Leishmania infantum indirect fluorescent antibody test (IFAT), delayed-type hypersensitivity reaction to leishmanin (DTH) and ..
  6. da Silva J, Werneck G, Macedo E, de Carvalho H, Cruz M. Factors associated with Leishmania chagasi infection in domestic dogs from Teresina, State of Piauí, Brazil. Rev Soc Bras Med Trop. 2012;45:480-4 pubmed
  7. Pratlong F, Lami P, Ravel C, Balard Y, Dereure J, Serres G, et al. Geographical distribution and epidemiological features of Old World Leishmania infantum and Leishmania donovani foci, based on the isoenzyme analysis of 2277 strains. Parasitology. 2013;140:423-34 pubmed publisher
    ..archibaldi (3 zymodemes, 46 strains) and L. infantum (37 zymodemes, 2,062 strains). The taxonomic position of these isoenzymatic groups is discussed in view of contradictory results obtained from recent molecular studies...
  8. Barbosa M, Alexandre Pires G, Soares Clemente M, Marques C, Rodrigues O, De Brito T, et al. Cytokine gene expression in the tissues of dogs infected by Leishmania infantum. J Comp Pathol. 2011;145:336-44 pubmed publisher
    Canine leishmaniosis (CanL) caused by the protozoan parasite Leishmania infantum is a chronic systemic disease that is endemic in certain parts of the world. The domestic dog is the most important reservoir of L...
  9. Gazanion E, Seblová V, Votypka J, Vergnes B, Garcia D, Volf P, et al. Leishmania infantum nicotinamidase is required for late-stage development in its natural sand fly vector, Phlebotomus perniciosus. Int J Parasitol. 2012;42:323-7 pubmed
    b>Leishmania infantum nicotinamidase, encoded by the Lipnc1 gene, converts nicotinamide into nicotinicacid to ensure Nicotinamide–Adenine–Dinucleotide (NAD+) biosynthesis. We were curious to explore the role of this enzyme during L...

More Information

Publications84

  1. Ferreira S, Almeida G, Silva S, Vogas G, Fujiwara R, de Andrade A, et al. Nasal, oral and ear swabs for canine visceral leishmaniasis diagnosis: new practical approaches for detection of Leishmania infantum DNA. PLoS Negl Trop Dis. 2013;7:e2150 pubmed publisher
    ..The aim of this study was to evaluate the potential use of nasal, oral, and ear swabs for molecular diagnosis of canine visceral leishmaniasis (CVL) in an endemic urban area in Brazil...
  2. Baiocco P, Poce G, Alfonso S, Cocozza M, Porretta G, Colotti G, et al. Inhibition of Leishmania infantum trypanothione reductase by azole-based compounds: a comparative analysis with its physiological substrate by X-ray crystallography. ChemMedChem. 2013;8:1175-83 pubmed publisher
    ..Enzymatic assays on Leishmania infantum trypanothione reductase (LiTR, belonging to the Leishmania donovani complex) shed light on both the ..
  3. Ilari A, Baiocco P, Messori L, Fiorillo A, Boffi A, Gramiccia M, et al. A gold-containing drug against parasitic polyamine metabolism: the X-ray structure of trypanothione reductase from Leishmania infantum in complex with auranofin reveals a dual mechanism of enzyme inhibition. Amino Acids. 2012;42:803-11 pubmed publisher
    ..Trypanothione reductase is a key enzyme of Leishmania infantum polyamine-dependent redox metabolism, and a validated target for antileishmanial drugs...
  4. Shang L, Peng W, Jin H, Xu D, Zhong N, Wang W, et al. The prevalence of canine Leishmania infantum infection in Sichuan Province, southwestern China detected by real time PCR. Parasit Vectors. 2011;4:173 pubmed publisher
    ..Infected dogs are the main reservoir for Leishmania infantum, and a potential sentinel for human VL in endemic areas...
  5. Vale Costa S, Gomes Pereira S, Teixeira C, Rosa G, Rodrigues P, Tomás A, et al. Iron overload favors the elimination of Leishmania infantum from mouse tissues through interaction with reactive oxygen and nitrogen species. PLoS Negl Trop Dis. 2013;7:e2061 pubmed publisher
    ..Additionally, the direct toxicity of iron against Leishmania suggests a potential use of this metal as a therapeutic tool or the further exploration of iron anti-parasitic mechanisms for the design of new drugs...
  6. Carrión J, Folgueira C, Soto M, Fresno M, Requena J. Leishmania infantum HSP70-II null mutant as candidate vaccine against leishmaniasis: a preliminary evaluation. Parasit Vectors. 2011;4:150 pubmed publisher
    ..Visceral leishmaniasis is the most severe form of leishmaniasis and no effective vaccine exists. The use of live attenuated vaccines is emerging as a promising vaccination strategy...
  7. de Arruda M, Figueiredo F, Cardoso F, Hiamamoto R, Brazuna J, de Oliveira M, et al. Validity and reliability of enzyme immunoassays using Leishmania major or L. infantum antigens for the diagnosis of canine visceral leishmaniasis in Brazil. PLoS ONE. 2013;8:e69988 pubmed publisher
    American visceral leishmaniasis is caused by the protozoan Leishmania infantum. Dogs are the main reservoirs in the domestic transmission cycle...
  8. Dostálová A, Votypka J, Favreau A, Barbian K, Volf P, Valenzuela J, et al. The midgut transcriptome of Phlebotomus (Larroussius) perniciosus, a vector of Leishmania infantum: comparison of sugar fed and blood fed sand flies. BMC Genomics. 2011;12:223 pubmed publisher
    ..Trypsin expression was measured in Leishmania infantum-infected and uninfected sand flies, which identified the L...
  9. Maia C, Seblová V, Sadlova J, Votypka J, Volf P. Experimental transmission of Leishmania infantum by two major vectors: a comparison between a viscerotropic and a dermotropic strain. PLoS Negl Trop Dis. 2011;5:e1181 pubmed publisher
    We quantified Leishmania infantum parasites transmitted by natural vectors for the first time. Both L...
  10. Maia C, Campino L. Can domestic cats be considered reservoir hosts of zoonotic leishmaniasis?. Trends Parasitol. 2011;27:341-4 pubmed publisher
    Canine and human zoonotic leishmaniasis caused by Leishmania infantum, which is transmitted by the bite of infected phlebotomine sand flies, is a serious public health problem in the Mediterranean basin and Latin America...
  11. Matrangolo F, Liarte D, Andrade L, de Melo M, Andrade J, Ferreira R, et al. Comparative proteomic analysis of antimony-resistant and -susceptible Leishmania braziliensis and Leishmania infantum chagasi lines. Mol Biochem Parasitol. 2013;190:63-75 pubmed publisher
    ..proteomic analysis of antimony-susceptible and antimony-resistant Leishmania braziliensis (LbSbR) and Leishmania infantum chagasi (LcSbR) lines was carried out using two-dimensional gel electrophoresis (2-DE) followed by mass ..
  12. Colombo F, Odorizzi R, Laurenti M, Galati E, Canavez F, Pereira Chioccola V. Detection of Leishmania (Leishmania) infantum RNA in fleas and ticks collected from naturally infected dogs. Parasitol Res. 2011;109:267-74 pubmed publisher
    ..The presence of viable L. (L.) infantum in ticks suggests the possible importance of dog ectoparasites in CVL dissemination. ..
  13. Coura Vital W, Marques M, Giunchetti R, Teixeira Carvalho A, Moreira N, Vitoriano Souza J, et al. Humoral and cellular immune responses in dogs with inapparent natural Leishmania infantum infection. Vet J. 2011;190:e43-7 pubmed publisher
    ..T lymphocytes and their subsets, B lymphocytes and monocytes were performed on dogs naturally infected with Leishmania infantum. Animals were categorised as asymptomatic dogs I (AD-I), with negative serology and positive molecular ..
  14. Michel G, Ferrua B, Lang T, Maddugoda M, Munro P, Pomares C, et al. Luciferase-expressing Leishmania infantum allows the monitoring of amastigote population size, in vivo, ex vivo and in vitro. PLoS Negl Trop Dis. 2011;5:e1323 pubmed publisher
    Here we engineered transgenic Leishmania infantum that express luciferase, the objectives being to more easily monitor in real time their establishment either in BALB/c mice--the liver and spleen being mainly studied-or in vitro...
  15. Fernández Cotrina J, Iniesta V, Belinchon Lorenzo S, Muñoz Madrid R, Serrano F, Parejo J, et al. Experimental model for reproduction of canine visceral leishmaniosis by Leishmania infantum. Vet Parasitol. 2013;192:118-28 pubmed publisher
    In this report an experimental model of Leishmania infantum (L. infantum) infection in dogs is described...
  16. Rodriguez N, Gaur Dixit U, Allen L, Wilson M. Stage-specific pathways of Leishmania infantum chagasi entry and phagosome maturation in macrophages. PLoS ONE. 2011;6:e19000 pubmed publisher
    ..These results suggest a model in which promastigotes and amastigotes use different mechanisms to enter macrophages, modulate the kinetics of phagosome maturation, and facilitate their intracellular survival...
  17. Miró G, Montoya A, Roura X, Gálvez R, Sainz A. Seropositivity rates for agents of canine vector-borne diseases in Spain: a multicentre study. Parasit Vectors. 2013;6:117 pubmed publisher
    ..to determine seropositivity rates in Spain for agents causing the following five CVBD: leishmaniosis (Leishmania infantum: Li), heartworm (Dirofilaria immitis: Di), ehrlichiosis (Ehrlichia canis: Ec), anaplasmosis (Anaplasma ..
  18. Mohammadi Ghalehbin B, Hatam G, Sarkari B, Mohebali M, Zare Z, Jaberipour M, et al. A Leishmania infantum FML-ELISA for the detection of symptomatic and asymptomatic canine visceral leishmaniasis in an endemic area of Iran. Iran J Immunol. 2011;8:244-50 pubmed publisher
    Visceral leishmaniasis (VL) is caused by Leishmania infantum in Mediterranean basin and is an endemic disease in some parts of Iran. Canines are the main reservoirs of VL in most of the endemic areas...
  19. Grimaldi G, Teva A, Santos C, Ferreira A, Falqueto A. The effect of removing potentially infectious dogs on the numbers of canine Leishmania infantum infections in an endemic area with high transmission rates. Am J Trop Med Hyg. 2012;86:966-71 pubmed publisher
    ..prevalence and incidence of canine infections, a prospective study was undertaken in an area endemic for Leishmania infantum. We used serological testing based on the rapid DPP rK28 fusion protein chromatographic immunoassay for ..
  20. Brotherton M, Bourassa S, Leprohon P, Legare D, Poirier G, Droit A, et al. Proteomic and genomic analyses of antimony resistant Leishmania infantum mutant. PLoS ONE. 2013;8:e81899 pubmed publisher
    ..Antimonials remain the primary antileishmanial drugs in most developing countries. However, drug resistance to these compounds is increasing and our understanding of resistance mechanisms is partial...
  21. Agallou M, Smirlis D, Soteriadou K, Karagouni E. Vaccination with Leishmania histone H1-pulsed dendritic cells confers protection in murine visceral leishmaniasis. Vaccine. 2012;30:5086-93 pubmed publisher
    ..The above data indicate the immunostimulatory capacity of Leishmania histone H1 and further support its exploitation as a candidate protein for vaccine development against leishmaniasis...
  22. Chitimia L, Muñoz García C, Sánchez Velasco D, Lizana V, Del Rio L, Murcia L, et al. Cryptic Leishmaniosis by Leishmania infantum, a feature of canines only? A study of natural infection in wild rabbits, humans and dogs in southeastern Spain. Vet Parasitol. 2011;181:12-6 pubmed publisher
    An epidemiological study was carried out to investigate asymptomatic Leishmania infantum infection by PCR and ELISA in wild rabbits, humans and domestic dogs in southeastern Spain...
  23. Alcolea P, Alonso A, Larraga V. Proteome profiling of Leishmania infantum promastigotes. J Eukaryot Microbiol. 2011;58:352-8 pubmed publisher
    A proteome analysis of the promastigote stage of the trypanosomatid parasite Leishmania infantum (MON-1 zymodeme) is described here for the first time...
  24. Chaouch M, Mhadhbi M, Adams E, Schoone G, Limam S, Gharbi Z, et al. Development and evaluation of a loop-mediated isothermal amplification assay for rapid detection of Leishmania infantum in canine leishmaniasis based on cysteine protease B genes. Vet Parasitol. 2013;198:78-84 pubmed publisher
    We developed a Leishmania infantum specific LAMP assay that was carried out using a set of, six primers targeting the cysteine protease B multi copy gene of L. infantum. Our result shows that we, successfully detect the L...
  25. Hartemink N, Vanwambeke S, Heesterbeek H, Rogers D, Morley D, Pesson B, et al. Integrated mapping of establishment risk for emerging vector-borne infections: a case study of canine leishmaniasis in southwest France. PLoS ONE. 2011;6:e20817 pubmed publisher
    ..The disease's causative agent, Leishmania infantum, is transmitted by blood-feeding female sandflies...
  26. Ferreira G, Dos Santos B, Dorval M, Ramos T, Porrozzi R, Peixoto A, et al. The genetic structure of Leishmania infantum populations in Brazil and its possible association with the transmission cycle of visceral leishmaniasis. PLoS ONE. 2012;7:e36242 pubmed publisher
    b>Leishmania infantum is the etiologic agent of visceral leishmaniasis (VL) in the Americas, Mediterranean basin and West and Central Asia. Although the geographic structure of L...
  27. Batista L, Segatto M, Guedes C, Sousa R, Rodrigues C, Brazuna J, et al. An assessment of the genetic diversity of Leishmania infantum isolates from infected dogs in Brazil. Am J Trop Med Hyg. 2012;86:799-806 pubmed publisher
    Correlations between the genetic diversity of Leishmania infantum (syn. L. chagasi) isolates and their respective geographic origins support the theoretic assumption that visceral leishmaniasis probably originated in the Old World...
  28. Zanette M, Lima V, Laurenti M, Rossi C, Vides J, Vieira R, et al. Serological cross-reactivity of Trypanosoma cruzi, Ehrlichia canis, Toxoplasma gondii, Neospora caninum and Babesia canis to Leishmania infantum chagasi tests in dogs. Rev Soc Bras Med Trop. 2014;47:105-7 pubmed publisher
    ..The aim of this study was to evaluate the serological cross-reactivity between Leishmania sp. and other canine pathogens...
  29. Jimenez M, Gonzalez E, Martín Martín I, Hernandez S, Molina R. Could wild rabbits (Oryctolagus cuniculus) be reservoirs for Leishmania infantum in the focus of Madrid, Spain?. Vet Parasitol. 2014;202:296-300 pubmed publisher
    ..high population of wild rabbits (Oryctolagus cuniculus) is present in the area, which shows detectable anti-Leishmania infantum antibodies and a large number of individuals with DNA of this parasite...
  30. Faucher B, Pomares C, Fourcade S, Benyamine A, Marty P, Pratlong L, et al. Mucosal Leishmania infantum leishmaniasis: specific pattern in a multicentre survey and historical cases. J Infect. 2011;63:76-82 pubmed publisher
    b>Leishmania infantum mucosally restricted leishmaniasis was rarely reported, so that diagnostic and treatment strategies remain debated. A long-term multicentric survey appeared thereby necessary.
  31. Jimenez M, Gonzalez E, Iriso A, Marco E, Alegret A, Fúster F, et al. Detection of Leishmania infantum and identification of blood meals in Phlebotomus perniciosus from a focus of human leishmaniasis in Madrid, Spain. Parasitol Res. 2013;112:2453-9 pubmed publisher
    ..of leishmaniasis proved that hares (Lepus granatensis) from this focus are able to infect with Leishmania infantum colonized Phlebotomus perniciosus...
  32. Farkas R, Tánczos B, Bongiorno G, Maroli M, Dereure J, Ready P. First surveys to investigate the presence of canine leishmaniasis and its phlebotomine vectors in Hungary. Vector Borne Zoonotic Dis. 2011;11:823-34 pubmed publisher
    ..imported dogs have increased in the last decade, raising concerns about the introduction of CanL caused by Leishmania infantum. Serum samples were collected from 725 dogs (22 localities, 6 counties) that had never traveled to endemic ..
  33. Lima I, Queiroz J, Lacerda H, Queiroz P, Pontes N, Barbosa J, et al. Leishmania infantum chagasi in northeastern Brazil: asymptomatic infection at the urban perimeter. Am J Trop Med Hyg. 2012;86:99-107 pubmed publisher
    ..We determined the prevalence of asymptomatic human infection with Leishmania infantum chagasi and associated environmental risks around Natal...
  34. Giorgobiani E, Chitadze N, Chanturya G, Grdzelidze M, Jochim R, Machablishvili A, et al. Epidemiologic aspects of an emerging focus of visceral leishmaniasis in Tbilisi, Georgia. PLoS Negl Trop Dis. 2011;5:e1415 pubmed publisher
    ..Over the last 15 years, visceral leishmaniasis (VL) has emerged as a public health concern in Tbilisi, the capital of Georgia...
  35. Hargrove T, Wawrzak Z, Liu J, Nes W, Waterman M, Lepesheva G. Substrate preferences and catalytic parameters determined by structural characteristics of sterol 14alpha-demethylase (CYP51) from Leishmania infantum. J Biol Chem. 2011;286:26838-48 pubmed publisher
    ..Here we report the structure/function characterization of sterol 14?-demethylase (CYP51) from Leishmania infantum. The enzyme catalyzes removal of the 14?-methyl group from sterol precursors...
  36. Wang J, Ha Y, Gao C, Wang Y, Yang Y, Chen H. The prevalence of canine Leishmania infantum infection in western China detected by PCR and serological tests. Parasit Vectors. 2011;4:69 pubmed publisher
    ..It is essential to evaluate the prevalence of canine Leishmania infantum infection for designing control policy...
  37. Dantas Torres F. Ticks as vectors of Leishmania parasites. Trends Parasitol. 2011;27:155-9 pubmed publisher
    ..In particular, the hypothesis of ticks as vectors of Leishmania infantum was studied in the 20th century and today is being revisited using modern molecular biology techniques...
  38. de Morais R, Gonçalves S, Costa P, da Silva K, da Silva F, Silva R, et al. Detection of Leishmania infantum in animals and their ectoparasites by conventional PCR and real time PCR. Exp Appl Acarol. 2013;59:473-81 pubmed publisher
    Visceral leishmaniosis (VL) is a parasitic disease caused by Leishmania infantum, which is primarily transmitted by phlebotomine sandflies...
  39. Coura Vital W, Reis A, Fausto M, Leal G, Marques M, Veloso V, et al. Risk factors for seroconversion by Leishmania infantum in a cohort of dogs from an endemic area of Brazil. PLoS ONE. 2013;8:e71833 pubmed publisher
    ..Identifying risk factors for seroconversion in dogs is crucial for developing adequate strategies for VL prevention and control...
  40. Suárez Rodríguez B, Isidoro Fernández B, Santos Sanz S, Sierra Moros M, Molina Moreno R, Astray Mochales J, et al. [Review of the current situation and the risk factors of Leishmania infantum in Spain]. Rev Esp Salud Publica. 2012;86:555-64 pubmed publisher
    ..The parasite detected is Leishmania infantum and the main reservoir is the dog...
  41. Faye B, Bucheton B, Bañuls A, Senghor M, Niang A, Diedhiou S, et al. Seroprevalence of Leishmania infantum in a rural area of Senegal: analysis of risk factors involved in transmission to humans. Trans R Soc Trop Med Hyg. 2011;105:333-40 pubmed publisher
    Whereas Leishmania infantum, the agent of visceral leishmaniasis (VL), is well known in North Africa, very limited data exist on its spread in West Africa, where mainly cutaneous leishmaniasis has been widely reported...
  42. Ritt J, Raymond F, Leprohon P, Legare D, Corbeil J, Ouellette M. Gene amplification and point mutations in pyrimidine metabolic genes in 5-fluorouracil resistant Leishmania infantum. PLoS Negl Trop Dis. 2013;7:e2564 pubmed publisher
    ..The human protozoan parasites Leishmania are prototrophic for pyrimidines with the ability of both de novo biosynthesis and uptake of pyrimidines...
  43. Cavalcanti A, Lobo R, Cupolillo E, Bustamante F, Porrozzi R. Canine cutaneous leishmaniasis caused by neotropical Leishmania infantum despite of systemic disease: A case report. Parasitol Int. 2012;61:738-40 pubmed publisher
    Visceral leishmaniasis is an anthropozoonosis caused by a protozoan Leishmania infantum (syn. Leishmania chagasi). Here, we report a typical case of canine cutaneous leishmaniasis due to L...
  44. Motoie G, Ferreira G, Cupolillo E, Canavez F, Pereira Chioccola V. Spatial distribution and population genetics of Leishmania infantum genotypes in São Paulo State, Brazil, employing multilocus microsatellite typing directly in dog infected tissues. Infect Genet Evol. 2013;18:48-59 pubmed publisher
    This study investigated the genetic characteristics of Leishmania infantum samples from São Paulo (SP) State, Brazil in order to collaborate with information about the possible origins of the parasites, as well as, the introduction and ..
  45. Nascimento M, Albuquerque T, Do Valle Matta M, Caldas I, Diniz L, Talvani A, et al. Naturally Leishmania infantum-infected dogs display an overall impairment of chemokine and chemokine receptor expression during visceral leishmaniasis. Vet Immunol Immunopathol. 2013;153:202-8 pubmed publisher
    Dogs are the primary reservoir for Leishmania parasites. The immune response induced by Leishmania infantum infection in these animals has not been completely elucidated, and few studies have investigated the relationship between the ..
  46. Athanasiou L, Kontos V, Saridomichelakis M, Rallis T, Diakou A. A cross-sectional sero-epidemiological study of canine leishmaniasis in Greek mainland. Acta Trop. 2012;122:291-5 pubmed publisher
    ..Epidemiological data on the seroprevalence of canine leishmaniasis provide indirect information on the prevalence of the infection and the disease and are necessary to implement and then to evaluate the effectiveness of control measures...
  47. Moreno I, Alvarez J, Garcia N, de la Fuente S, MARTINEZ I, Marino E, et al. Detection of anti-Leishmania infantum antibodies in sylvatic lagomorphs from an epidemic area of Madrid using the indirect immunofluorescence antibody test. Vet Parasitol. 2014;199:264-7 pubmed publisher
    ..Using promastigotes from six culture passages and a 1/25 threshold titer, we found anti-Leishmania infantum seroreactivity in 9.3% of cats (4 of 43), 45.7% of rabbits (16/35) and 74.1% of hares (63/85)...
  48. Foglia Manzillo V, Di Muccio T, Cappiello S, Scalone A, Paparcone R, Fiorentino E, et al. Prospective study on the incidence and progression of clinical signs in naïve dogs naturally infected by Leishmania infantum. PLoS Negl Trop Dis. 2013;7:e2225 pubmed publisher
    ..with the progression of infection was evaluated prospectively in 329 naïve young dogs exposed to Leishmania infantum transmission and examined periodically during 22 months (M)...
  49. Berdjane Brouk Z, Charrel R, Hamrioui B, Izri A. First detection of Leishmania infantum DNA in Phlebotomus longicuspis Nitzulescu, 1930 from visceral leishmaniasis endemic focus in Algeria. Parasitol Res. 2012;111:419-22 pubmed publisher
    Two clinico-epidemiological forms of leishmaniasis caused by Leishmania infantum complex are endemic in Algeria: human visceral leishmaniasis (HVL) and sporadic cutaneous leishmaniasis...
  50. Rodriguez Cortes A, Ojeda A, Todolí F, Alberola J. Performance of commercially available serological diagnostic tests to detect Leishmania infantum infection on experimentally infected dogs. Vet Parasitol. 2013;191:363-6 pubmed publisher
    b>Leishmania infantum (syn. Leishmania chagasi) is the etiological agent of a widespread serious zoonotic disease that affects both humans and dogs...
  51. Sousa S, Lopes A, Cardoso L, Silvestre R, Schallig H, Reed S, et al. Seroepidemiological survey of Leishmania infantum infection in dogs from northeastern Portugal. Acta Trop. 2011;120:82-7 pubmed publisher
    ..2%) and those living in a mixed habitat (27.5%). Risk factors for canine Leishmania infection, as defined by multiple logistic regression analysis, were of clinical status (odds ratio [OR] = 3.1) and Toxoplasma infection (OR = 1.5)...
  52. Reimão J, Colombo F, Pereira Chioccola V, Tempone A. Effectiveness of liposomal buparvaquone in an experimental hamster model of Leishmania (L.) infantum chagasi. Exp Parasitol. 2012;130:195-9 pubmed publisher
    ..These results show the potential of PS-liposome formulations for the successful targeted delivery of BPQ in visceral leishmaniasis...
  53. Vale Costa S, Vale N, Matos J, Tomás A, Moreira R, Gomes P, et al. Peptidomimetic and organometallic derivatives of primaquine active against Leishmania infantum. Antimicrob Agents Chemother. 2012;56:5774-81 pubmed publisher
    ..decided to evaluate these compounds against both the promastigote and intramacrophagic amastigote forms of Leishmania infantum, the agent of Mediterranean visceral leishmaniasis...
  54. Brotherton M, Racine G, Ouameur A, Leprohon P, Papadopoulou B, Ouellette M. Analysis of membrane-enriched and high molecular weight proteins in Leishmania infantum promastigotes and axenic amastigotes. J Proteome Res. 2012;11:3974-85 pubmed publisher
    ..This allowed the study of expression of both membrane-enriched and HMW proteins in Leishmania infantum promastigotes and amastigotes...
  55. Coelho Finamore J, Freitas V, Assis R, Melo M, Novozhilova N, Secundino N, et al. Leishmania infantum: Lipophosphoglycan intraspecific variation and interaction with vertebrate and invertebrate hosts. Int J Parasitol. 2011;41:333-42 pubmed publisher
    ..However, the degree of intraspecies polymorphism in LPG of Leishmania infantum (syn. Leishmania chagasi) is not known...
  56. Hernandez L, Gálvez R, Montoya A, Checa R, Bello A, Bosschaerts T, et al. First study on efficacy and tolerability of a new alkylphosphocholine molecule (oleylphosphocholine-OlPC) in the treatment of canine leishmaniosis due to Leishmania infantum. Parasitol Res. 2014;113:157-64 pubmed publisher
    ..OlPC) represents a potential new therapy for the treatment of canine leishmaniosis caused by Leishmania infantum. The aim of the present study was to evaluate the efficacy and safety of OlPC in a small cohort of dogs ..
  57. Naucke T, Lorentz S. First report of venereal and vertical transmission of canine leishmaniosis from naturally infected dogs in Germany. Parasit Vectors. 2012;5:67 pubmed publisher
    ..It is transmitted by phlebotomine sandflies but occasional non-vector transmissions have been reported, including vertical and horizontal transmission...
  58. Malafaia G, Marcon L, Pereira L, Pedrosa M, Rezende S. Leishmania chagasi: effect of the iron deficiency on the infection in BALB/c mice. Exp Parasitol. 2011;127:719-23 pubmed publisher
    ..In conclusion, the data reported in this paper suggest that iron deficiency may favor the host. If there is not enough iron available to the parasite, its multiplication may be reduced and infection attenuated...
  59. Moreira W, Leprohon P, Ouellette M. Tolerance to drug-induced cell death favours the acquisition of multidrug resistance in Leishmania. Cell Death Dis. 2011;2:e201 pubmed publisher
    ..apoptosis in Leishmania and this death mechanism was further studied in drug-sensitive and drug-resistant Leishmania infantum. In sensitive parasites, antimonials (SbIII), miltefosine (MF) and amphotericin B (AMB), but not ..
  60. Daneshvar H, Wyllie S, Phillips S, Hagan P, Burchmore R. Comparative proteomics profiling of a gentamicin-attenuated Leishmania infantum cell line identifies key changes in parasite thiol-redox metabolism. J Proteomics. 2012;75:1463-71 pubmed publisher
    We have previously described an attenuated line of Leishmania infantum (H-line), selected by culturing promastigotes in vitro in the presence of gentamicin...
  61. Casanova E, Moreno D, Gigante A, Rico E, Genes C, Oliva C, et al. 5'-Trityl-substituted thymidine derivatives as a novel class of antileishmanial agents: Leishmania infantum EndoG as a potential target. ChemMedChem. 2013;8:1161-74 pubmed publisher
    ..series of 5'-triphenylmethyl (trityl)-substituted thymidine derivatives were synthesized and tested against Leishmania infantum axenic promastigotes and amastigotes...
  62. Lynn M, Marr A, McMaster W. Differential quantitative proteomic profiling of Leishmania infantum and Leishmania mexicana density gradient separated membranous fractions. J Proteomics. 2013;82:179-92 pubmed publisher
    ..Leishmania mexicana and Leishmania infantum are causative agents of cutaneous and visceral leishmaniasis, respectively...
  63. Carreira J, da Silva A, de Pita Pereira D, Brazil R. Natural infection of Didelphis aurita (Mammalia: Marsupialia) with Leishmania infantum in Brazil. Parasit Vectors. 2012;5:111 pubmed publisher
    ..marsupialis and D. albiventris), have been mentioned as natural hosts of Leishmania infantum in Brazil and Colombia...
  64. Moreira D, Santarém N, Loureiro I, Tavares J, Silva A, Amorim A, et al. Impact of continuous axenic cultivation in Leishmania infantum virulence. PLoS Negl Trop Dis. 2012;6:e1469 pubmed publisher
    ..These results highlight the need for a standard operating protocol (SOP) when studying Leishmania species...
  65. Vlková M, Rohousova I, Drahota J, Stanneck D, Kruedewagen E, Mencke N, et al. Canine antibody response to Phlebotomus perniciosus bites negatively correlates with the risk of Leishmania infantum transmission. PLoS Negl Trop Dis. 2011;5:e1344 pubmed publisher
    ..In this study, we examined the canine antibody response against the saliva of Phlebotomus perniciosus, the main vector of Leishmania infantum in the Mediterranean Basin, and characterized salivary antigens of this sand fly species.
  66. Alcolea P, Alonso A, Larraga V. Genome-wide gene expression profile induced by exposure to cadmium acetate in Leishmania infantum promastigotes. Int Microbiol. 2011;14:1-11 pubmed
    b>Leishmania infantum is the etiological agent of visceral leishmaniasis in Mediterranean areas...
  67. Soares I, Silva S, Moreira F, Prado L, Fantini P, Maranhão R, et al. First evidence of autochthonous cases of Leishmania (Leishmania) infantum in horse (Equus caballus) in the Americas and mixed infection of Leishmania infantum and Leishmania (Viannia) braziliensis. Vet Parasitol. 2013;197:665-9 pubmed publisher
    This study reports the first evidence of infection by Leishmania infantum in Equus caballus in Americas and the first mixed infection of L. infantum/Leishmania braziliensis on this mammalian species in the world...
  68. Oliveira D, Costa M, Chávez Fumagalli M, Valadares D, Duarte M, Costa L, et al. Evaluation of parasitological and immunological parameters of Leishmania chagasi infection in BALB/c mice using different doses and routes of inoculation of parasites. Parasitol Res. 2012;110:1277-85 pubmed publisher
    ..chagasi in BALB/c mice can bring about an imbalance in the animals' immune response, thus allowing for the development of the disease at the expense of efficacy within the vaccine candidates...
  69. Daneshvar H, Molaei M, Kamiabi H, Burchmore R, Hagan P, Stephen Phillips R. Gentamicin-attenuated Leishmania infantum: cellular immunity production and protection of dogs against experimental canine leishmaniasis. Parasite Immunol. 2010;32:722-30 pubmed publisher
    An attenuated line of Leishmania infantum (L. infantum H-line) has been established by culturing promastigotes in vitro under gentamicin pressure. Here, we show that L...
  70. Boggiatto P, Gibson Corley K, Metz K, Gallup J, Hostetter J, Mullin K, et al. Transplacental transmission of Leishmania infantum as a means for continued disease incidence in North America. PLoS Negl Trop Dis. 2011;5:e1019 pubmed publisher
    ..infantum transmission in U.S. dogs is currently unknown. Possibilities include vertical (transplacental/transmammary) and horizontal/venereal transmission. Several reports have indicated that endemic ZVL may be transmitted vertically...
  71. Dantas Torres F, Latrofa M, Otranto D. Quantification of Leishmania infantum DNA in females, eggs and larvae of Rhipicephalus sanguineus. Parasit Vectors. 2011;4:56 pubmed publisher
    b>Leishmania infantum is a widespread parasite that affects dogs and humans worldwide...
  72. Guerra N, Vega Sendino M, P rez Morgado M, Ramos E, Soto M, Gonzalez V, et al. Identification and functional characterization of a poly(A)-binding protein from Leishmania infantum (LiPABP). FEBS Lett. 2011;585:193-8 pubmed publisher
    ..We describe a PABP from Leishmania infantum (LiPABP) that shows a very high homology with PABPs from other eukaryotic organisms, including mammals and ..
  73. Ballart C, Alcover M, Picado A, Nieto J, Castillejo S, Portús M, et al. First survey on canine leishmaniasis in a non classical area of the disease in Spain (Lleida, Catalonia) based on a veterinary questionnaire and a cross-sectional study. Prev Vet Med. 2013;109:116-27 pubmed publisher
    ..The seroprevalence study carried out on kennel dogs of local origin proved useful for detecting an autochthonous focus of leishmaniasis through the analysis of a small number of animals...
  74. Ballart C, Alcover M, Portus M, Gallego M. Is leishmaniasis widespread in Spain? First data on canine leishmaniasis in the province of Lleida, Catalonia, northeast Spain. Trans R Soc Trop Med Hyg. 2012;106:134-6 pubmed publisher
    ..Since the dog had never left the region and sandfly vectors, Phlebotomus ariasi and P. perniciosus, were present in the farm the case is considered as autochthonous and is the first to be published in this region of Spain...
  75. Giorgobiani E, Lawyer P, Babuadze G, Dolidze N, Jochim R, Tskhvaradze L, et al. Incrimination of Phlebotomus kandelakii and Phlebotomus balcanicus as vectors of Leishmania infantum in Tbilisi, Georgia. PLoS Negl Trop Dis. 2012;6:e1609 pubmed publisher
    ..The abundance, infection rate and feeding behavior of P. kandelakii and the infection rate in P. balcanicus establish these species as vectors in the Tbilisi VL focus...