leishmania guyanensis

Summary

Summary: A parasitic hemoflagellate of the subgenus Leishmania viannia that infects man and animals and causes mucocutaneous leishmaniasis (LEISHMANIASIS, MUCOCUTANEOUS). Transmission is by Lutzomyia sandflies.

Top Publications

  1. Bourreau E, Prevot G, Gardon J, Pradinaud R, Launois P. High intralesional interleukin-10 messenger RNA expression in localized cutaneous leishmaniasis is associated with unresponsiveness to treatment. J Infect Dis. 2001;184:1628-30 pubmed
    ..IL-10, and interferon-gamma) was analyzed in 65 patients with localized cutaneous leishmaniasis due to Leishmania guyanensis before specific treatment with pentamidine isethionate...
  2. Sousa Franco J, Araújo Mendes E, Silva Jardim I, L Santos J, Faria D, Dutra W, et al. Infection-induced respiratory burst in BALB/c macrophages kills Leishmania guyanensis amastigotes through apoptosis: possible involvement in resistance to cutaneous leishmaniasis. Microbes Infect. 2006;8:390-400 pubmed
    ..This innate killing mechanism of macrophages may account for the resistance of BALB/c mice to infection by L. guyanensis...
  3. Robledo S, Wozencraft A, Valencia A, Saravia N. Human monocyte infection by Leishmania (Viannia) panamensis. Role of complement receptors and correlation of susceptibility in vitro with clinical phenotype. J Immunol. 1994;152:1265-76 pubmed
    ..V). panamensis and demonstrate a correlation between clinical phenotype and in vitro infection of PBMs cultured in the presence of autologous plasma before experimental infection...
  4. Walker J, Acestor N, Gongora R, Quadroni M, Segura I, Fasel N, et al. Comparative protein profiling identifies elongation factor-1beta and tryparedoxin peroxidase as factors associated with metastasis in Leishmania guyanensis. Mol Biochem Parasitol. 2006;145:254-64 pubmed
    ..Both polypeptides are active in resistance to chemical and oxidant stress, providing a basis for further elucidation of the importance of antioxidant defence in the pathogenesis underlying MCL...
  5. Couppie P, Clyti E, Sainte Marie D, Dedet J, Carme B, Pradinaud R. Disseminated cutaneous leishmaniasis due to Leishmania guyanensis: case of a patient with 425 lesions. Am J Trop Med Hyg. 2004;71:558-60 pubmed
    ..These include anergic diffuse cutaneous leishmaniasis, post-kala-azar leishmaniasis, and leishmaniasis associated with HIV infection...
  6. Rotureau B, Ravel C, Nacher M, Couppie P, Curtet I, Dedet J, et al. Molecular epidemiology of Leishmania (Viannia) guyanensis in French Guiana. J Clin Microbiol. 2006;44:468-73 pubmed
    ..V.) guyanensis isolates from diverse ecological areas and with different clinical implications...
  7. Bourreau E, Ronet C, Darsissac E, Lise M, Marie D, Clity E, et al. In leishmaniasis due to Leishmania guyanensis infection, distinct intralesional interleukin-10 and Foxp3 mRNA expression are associated with unresponsiveness to treatment. J Infect Dis. 2009;199:576-9 pubmed publisher
    ..by the expression of Foxp3 mRNA, was analyzed in patients with localized leishmaniasis due to Leishmania guyanensis infection that was unresponsive to treatment with pentamidine isethionate...
  8. Bourreau E, Ronet C, Darcissac E, Lise M, Sainte Marie D, Clity E, et al. Intralesional regulatory T-cell suppressive function during human acute and chronic cutaneous leishmaniasis due to Leishmania guyanensis. Infect Immun. 2009;77:1465-74 pubmed publisher
    ..CD25(-) T cells purified from peripheral blood mononuclear cells from the same patient in response to Leishmania guyanensis stimulation...
  9. Romero G, Ishikawa E, Cupolillo E, Toaldo C, Guerra M, Paes M, et al. The rarity of infection with Leishmania (Viannia) braziliensis among patients from the Manaus region of Amazonas state, Brazil, who have cutaneous leishmaniasis. Ann Trop Med Parasitol. 2002;96:131-6 pubmed
    ..V.) guyanensis. In the Manaus region, therefore, almost all human cutaneous leishmaniasis is the result of infection with L. (V.) guyanensis, and L. ( V.) braziliensis is a relatively rare cause of the disease...

More Information

Publications86

  1. Chrusciak Talhari A, Ribeiro Rodrigues R, Talhari C, Silva R, Ferreira L, Botileiro S, et al. Tegumentary leishmaniasis as the cause of immune reconstitution inflammatory syndrome in a patient co-infected with human immunodeficiency virus and Leishmania guyanensis. Am J Trop Med Hyg. 2009;81:559-64 pubmed publisher
    ..inflammatory syndrome (IRIS) in a 32-year-old man infected with human immunodeficiency virus and Leishmania guyanensis. Three months after initiation of highly active anti-retroviral therapy (HAART), the patient had ..
  2. Gallego C, Golenbock D, Gomez M, Saravia N. Toll-like receptors participate in macrophage activation and intracellular control of Leishmania (Viannia) panamensis. Infect Immun. 2011;79:2871-9 pubmed publisher
    ..Together, these findings support the participation of TLR4 and endosomal TLRs in the activation of host macrophages by L. panamensis and in the early control of infection...
  3. Benicio E, Gadelha E, Talhari A, Silva R, Ferreira L, Santos M, et al. Combining diagnostic procedures for the management of leishmaniasis in areas with high prevalence of Leishmania guyanensis. An Bras Dermatol. 2011;86:1141-4 pubmed
    ..The study addresses how a combination of procedures improves diagnosis in areas with high prevalence of Leishmania guyanensis.
  4. Neves L, Talhari A, Gadelha E, Silva Junior R, Guerra J, Ferreira L, et al. A randomized clinical trial comparing meglumine antimoniate, pentamidine and amphotericin B for the treatment of cutaneous leishmaniasis by Leishmania guyanensis. An Bras Dermatol. 2011;86:1092-101 pubmed
    ..Moreover, treatment outcome may depend on the causative species of Leishmania...
  5. Bourreau E, Collet M, Prévot G, Milon G, Ashimoff D, Hasagewa H, et al. IFN-gamma-producing CD45RA+CD8+ and IL-10-producing CD45RA-CD4+ T cells generated in response to LACK in naive subjects never exposed to Leishmania. Eur J Immunol. 2002;32:510-20 pubmed
    b>Leishmania guyanensis (L.g.)-specific CD8+ T cells can be isolated from PBMC of subjects who have never been previously exposed to Leishmania. Cells that produce IFN-gamma in response to live L.g...
  6. Torres D, Adaui V, Ribeiro Alves M, Romero G, Arevalo J, Cupolillo E, et al. Targeted gene expression profiling in Leishmania braziliensis and Leishmania guyanensis parasites isolated from Brazilian patients with different antimonial treatment outcomes. Infect Genet Evol. 2010;10:727-33 pubmed publisher
    ..of parasite factors to this phenomenon, we characterised 12 Leishmania braziliensis (LB) and 25 Leishmania guyanensis (LG) isolates collected from patients experiencing different antimonial treatment outcomes...
  7. Scarpassa V, Alencar R. Lutzomyia umbratilis, the main vector of Leishmania guyanensis, represents a novel species complex?. PLoS ONE. 2012;7:e37341 pubmed publisher
    Lutzomyia umbratilis is an important Leishmania guyanensis vector in South America. Previous studies have suggested differences in the vector competence between L...
  8. Bourreau E, Prevot G, Pradinaud R, Launois P. Unresponsiveness of specific T cells to IL-12 is associated with active cutaneous leishmaniasis owing to Leishmania guyanensis. Scand J Immunol. 2001;54:335-9 pubmed
    ..More IL-13 was produced by specific T cells in response to Leishmania guyanensis (L. guyanensis) antigens in active compared to in inactive leishmaniasis...
  9. Bourreau E, Ronet C, Couppie P, Sainte Marie D, Tacchini Cottier F, Launois P. IL-10 producing CD8+ T cells in human infection with Leishmania guyanensis. Microbes Infect. 2007;9:1034-41 pubmed
    ..IL-10 and IFN-gamma by PBMC of unexposed naïve subjects and LCL patients after stimulation with live Leishmania guyanensis (L.g.)...
  10. Kariminia A, Bourreau E, Ronet C, Couppie P, Sainte Marie D, Tacchini Cottier F, et al. Selective expression of the V beta 14 T cell receptor on Leishmania guyanensis--specific CD8+ T cells during human infection. J Infect Dis. 2007;195:739-47 pubmed
    Peripheral blood mononuclear cells from subjects never exposed to Leishmania were stimulated with Leishmania guyanensis. We demonstrated that L...
  11. Kuhlmann F, Robinson J, Bluemling G, Ronet C, Fasel N, Beverley S. Antiviral screening identifies adenosine analogs targeting the endogenous dsRNA Leishmania RNA virus 1 (LRV1) pathogenicity factor. Proc Natl Acad Sci U S A. 2017;114:E811-E819 pubmed publisher
    ..models and human disease, and associated with drug-treatment failures in Leishmania braziliensis and Leishmania guyanensis infections. Thus, methods targeting LRV1 could have therapeutic benefit...
  12. Adaui V, Lye L, Akopyants N, Zimic M, Llanos Cuentas A, Garcia L, et al. Association of the Endobiont Double-Stranded RNA Virus LRV1 With Treatment Failure for Human Leishmaniasis Caused by Leishmania braziliensis in Peru and Bolivia. J Infect Dis. 2016;213:112-21 pubmed publisher
    ..contain a double-stranded RNA virus named Leishmaniavirus 1 (LRV1), which has also been reported in Leishmania guyanensis, for which an association with increased pathology, metastasis, and parasite replication was found in ..
  13. Kariminia A, Bourreau E, Pascalis H, Couppie P, Sainte Marie D, Tacchini Cottier F, et al. Transforming growth factor beta 1 production by CD4+ CD25+ regulatory T cells in peripheral blood mononuclear cells from healthy subjects stimulated with Leishmania guyanensis. Infect Immun. 2005;73:5908-14 pubmed
    ..peripheral blood mononuclear cells from healthy subjects never exposed to leishmaniae in response to live Leishmania guyanensis, and the TGF-beta1-producing cells were described as a distinct subpopulation of CD4(+) CD25(+) regulatory ..
  14. Ehrlich A, Fernández O, Rodriguez Pinto D, Castilho T, Corral Caridad M, Goldsmith Pestana K, et al. Local Delivery of the Toll-Like Receptor 9 Ligand CpG Downregulates Host Immune and Inflammatory Responses, Ameliorating Established Leishmania (Viannia) panamensis Chronic Infection. Infect Immun. 2017;85: pubmed publisher
  15. de Souza Freitas M, Ríos Velasquez C, da Silva L, Costa C, Marcelino A, Leal Balbino T, et al. Analysis of the genetic structure of allopatric populations of Lutzomyia umbratilis using the period clock gene. Acta Trop. 2016;154:149-54 pubmed publisher
    In South America, Lutzomyia umbratilis is the main vector of Leishmania guyanensis, one of the species involved in the transmission of American tegumentary leishmaniasis. In Brazil, L...
  16. Ginouvès M, Simon S, Bourreau E, Lacoste V, Ronet C, Couppié P, et al. Prevalence and Distribution of Leishmania RNA Virus 1 in Leishmania Parasites from French Guiana. Am J Trop Med Hyg. 2016;94:102-6 pubmed publisher
    In South America, the presence of the Leishmania RNA virus type 1 (LRV1) was described in Leishmania guyanensis and Leishmania braziliensis strains...
  17. Varela M R, Muñoz D, Robledo S, Kolli B, Dutta S, Chang K, et al. Leishmania (Viannia) panamensis: an in vitro assay using the expression of GFP for screening of antileishmanial drug. Exp Parasitol. 2009;122:134-9 pubmed publisher
    ..The availability of this fluorescent assay for infection of macrophages by L. (V.) panamensis facilitates drug discovery program for the Viannia species, which differ significantly from those of the Leishmania subgenus. ..
  18. Bourreau E, Ginouves M, Prévot G, Hartley M, Gangneux J, Robert Gangneux F, et al. Presence of Leishmania RNA Virus 1 in Leishmania guyanensis Increases the Risk of First-Line Treatment Failure and Symptomatic Relapse. J Infect Dis. 2016;213:105-11 pubmed publisher
    ..Such complications are seen frequently in Leishmania guyanensis infections, in which patients respond variously to first-line antileishmanials and are more prone to ..
  19. Eren R, Kopelyanskiy D, Moreau D, Chapalay J, Chambon M, Turcatti G, et al. Development of a semi-automated image-based high-throughput drug screening system. Front Biosci (Elite Ed). 2018;10:242-253 pubmed
    ..Moreover, this technique allows the concomitant assessment of the effect of drug toxicity on host cell number. ..
  20. Delgado G, Parra López C, Vargas L, Hoya R, Estupiñán M, Guzman F, et al. Characterizing cellular immune response to kinetoplastid membrane protein-11 (KMP-11) during Leishmania (Viannia) panamensis infection using dendritic cells (DCs) as antigen presenting cells (APCs). Parasite Immunol. 2003;25:199-209 pubmed
    ..The experimental approach used here may prove useful for characterizing T-cell epitopes in a protein useful in designing peptide-based vaccine candidates for Leishmania and other intracellular pathogens...
  21. Banuls A, Guerrini F, Le Pont F, Barrera C, Espinel I, Guderian R, et al. Evidence for hybridization by multilocus enzyme electrophoresis and random amplified polymorphic DNA between Leishmania braziliensis and Leishmania panamensis/guyanensis in Ecuador. J Eukaryot Microbiol. 1997;44:408-11 pubmed
    ..panamensis/guyanensis and L. braziliensis. MLEE data show that the results cannot be attributed to either mixture of stocks, or an F1 in the framework of a simple Mendelian inheritance. ..
  22. de Souza e Souza I, Naiff R, Guimarães T, Naiff M, Cupolillo E, Rodrigues W, et al. American cutaneous leishmaniasis due to Leishmania (Viannia) guyanensis as an initial clinical presentation of human immunodeficiency virus infection. J Eur Acad Dermatol Venereol. 1998;10:214-7 pubmed
    ..L.(V.) guyanenesis was typed by an immunoenzymatic technique. Various therapies were attempted, but the patient relapsed after each episode of treatment. ..
  23. Moreira E, Anacleto C, Petrillo Peixoto M. Effect of glucantime on field and patient isolates of New World Leishmania: use of growth parameters of promastigotes to assess antimony susceptibility. Parasitol Res. 1998;84:720-6 pubmed
    ..No amplified sequence could be detected, suggesting that pgpA amplification is not involved in glucantime resistance in these wild Leishmania strains. ..
  24. de Araujo F, da Silva L, Mesquita T, Pinheiro S, Vital W, Chrusciak Talhari A, et al. Polymorphisms in the TOLLIP Gene Influence Susceptibility to Cutaneous Leishmaniasis Caused by Leishmania guyanensis in the Amazonas State of Brazil. PLoS Negl Trop Dis. 2015;9:e0003875 pubmed publisher
    ..The r2 and D' linkage disequilibrium between the two polymorphisms are 0.05 and 0.473 with a confidence bounds of 0.37 to 0.57 respectively. The two polymorphisms are independently associated with an increased risk of developing CL. ..
  25. Espir T, Guerreiro T, Naiff M, Figueira L, Soares F, da Silva S, et al. Evaluation of different diagnostic methods of American Cutaneous Leishmaniasis in the Brazilian Amazon. Exp Parasitol. 2016;167:1-6 pubmed publisher
    ..However, flaws in specificity are observed in the diagnosis of cutaneous leishmaniasis. Actually the diagnosis needs to be done as an associated methods depending on the question to be solved. ..
  26. Mans D, Kent A, Hu R, Lai A Fat E, Schoone G, Adams E, et al. Monitoring the response of patients with cutaneous leishmaniasis to treatment with pentamidine isethionate by quantitative real-time PCR, and identification of Leishmania parasites not responding to therapy. Clin Exp Dermatol. 2016;41:610-5 pubmed publisher
    ..V.) braziliensis and L. (L.) amazonensis. Furthermore, patient response to PI can be better anticipated based on the parasite load 6 weeks after the treatment rather than on parasite load before treatment. ..
  27. Benício E, Cordeiro M, Monteiro H, Saboia Moura M, Oliveira C, Nunes Gadelha E, et al. Sustained Presence of Cutaneous Leishmaniasis in Urban Manaus, the Largest Human Settlement in the Amazon. Am J Trop Med Hyg. 2015;93:1208-13 pubmed publisher
    ..It cannot be determined from these data whether transmission of these cases occurred within or outside the city of Manaus. ..
  28. Dea Ayuela M, Bilbao Ramos P, Bolas Fernandez F, González Cardenete M. Synthesis and antileishmanial activity of C7- and C12-functionalized dehydroabietylamine derivatives. Eur J Med Chem. 2016;121:445-450 pubmed publisher
    ..Thus, the activity in vitro against Leishmania infantum, Leishmania donovani, Leishmania amazonensis and Leishmania guyanensis, was studied...
  29. de Souza Freitas M, Ríos Velasquez C, Costa C, Figueirêdo C, Aragão N, da Silva L, et al. Phenotypic and genotypic variations among three allopatric populations of Lutzomyia umbratilis, main vector of Leishmania guyanensis. Parasit Vectors. 2015;8:448 pubmed publisher
    In South America, Lutzomyia umbratilis is the main vector of Leishmania guyanensis, one of the species involved in the transmission of American tegumentary leishmaniasis. In Brazil, L...
  30. Rougeron V, de Meeus T, Hide M, Waleckx E, Dereure J, Arevalo J, et al. A battery of 12 microsatellite markers for genetic analysis of the Leishmania (Viannia) guyanensis complex. Parasitology. 2010;137:1879-84 pubmed publisher
    ..markers developed for Leishmania braziliensis to genotype 28 strains of the main species of the Leishmania guyanensis complex (i.e. L. guyanensis and L. panamensis) collected in Ecuador and Peru...
  31. Ro Y, Kim E, Lee H, Saiz M, Carrion R, Patterson J. Evidence that the fully assembled capsid of Leishmania RNA virus 1-4 possesses catalytically active endoribonuclease activity. Exp Mol Med. 2004;36:145-56 pubmed
    In this study, Leishmania RNA virus 1-4 (LRV1-4) particles purified from host Leishmania guyanensis promastigotes were examined for capsid endoribonuclease...
  32. Muñoz E, Santander S, Rojas Silva P, Cardenas P, Fornasini M, Cifuentes S, et al. Diagnostic Efficacy of Molecular Techniques for Detection and Identification of Leishmania Species in Human Whole Blood and Skin Samples from Ecuador. Am J Trop Med Hyg. 2016;95:803-805 pubmed
    ..Cytochrome b gene (cyt-b) amplification and sequencing identified Leishmania guyanensis, Leishmania shawi, and Leishmania naiffi from skin and blood samples...
  33. Fourcade S, Huber F, Blanchet D, Aznar C, Clyti E, Simon S, et al. [Mucocutaneous leishmaniasis due to Leishmania guyanensis: a case report in an HIV-infected patient]. Med Trop (Mars). 2008;68:533-6 pubmed
    ..braziliensis accounting for all previously reported cases. The purpose of this report is to describe a case of mucocutaneous leishmaniasis due to L. guyanensis that led to diagnosis of HIV infection in a patient living in French Guiana. ..
  34. Pascalis H, Lavergne A, Bourreau E, Prévot Linguet G, Kariminia A, Pradinaud R, et al. Th1 cell development induced by cysteine proteinases A and B in localized cutaneous leishmaniasis due to Leishmania guyanensis. Infect Immun. 2003;71:2924-6 pubmed
    ..proteinases CPA and CPB from Leishmania major induced Th1 responses in patients with leishmaniasis due to Leishmania guyanensis. Furthermore, cysteine proteinases induced neither interleukin 4 (IL-4) nor IL-13 and low levels of IL-10 ..
  35. Cruz Saavedra L, Díaz Roa A, Gaona M, Cruz M, Ayala M, Cortés Vecino J, et al. The effect of Lucilia sericata- and Sarconesiopsis magellanica-derived larval therapy on Leishmania panamensis. Acta Trop. 2016;164:280-289 pubmed publisher
    ..These results potentially validate effective LT treatment against cutaneous leishmaniasis aimed at using it with humans in the future. ..
  36. Castaño M, Cardona W, Quiñones W, Robledo S, Echeverri F. Leishmanicidal activity of aliphatic and aromatic lactones: correlation structure-activity. Molecules. 2009;14:2491-500 pubmed publisher
    ..It was also observed that a decrease in the size of the lactone ring increases the selectivity index...
  37. Martínez L, Rebollo J, Luna A, Cochero S, Bejarano E. Molecular identification of the parasites causing cutaneous leishmaniasis on the Caribbean coast of Colombia. Parasitol Res. 2010;106:647-52 pubmed publisher
    ..This represents the first report of the presence of L. (V.) guyanensis on the Caribbean coast of Colombia...
  38. Romero G, Ishikawa E, Cupolillo E, Toaldo C, Guerra M, Paes M, et al. Identification of antigenically distinct populations of Leishmania (Viannia) guyanensis from Manaus, Brazil, using monoclonal antibodies. Acta Trop. 2002;82:25-9 pubmed
    ..The lack of B19 expression by the L. (V.) guyanensis strains in the present study contrasts with that of the vast majority of the strains of the same parasite from eastern Amazonia and French Guyana that express the epitope...
  39. Miller D, Gilchrest B, Garg A, Goldberg L, Bhawan J. Acute New World cutaneous leishmaniasis presenting as tuberculoid granulomatous dermatitis. J Cutan Pathol. 2012;39:361-5 pubmed publisher
    ..PCR testing should be employed in cases with high clinical suspicion when histopathology is not definitive...
  40. Bourreau E, Prevot G, Pradinaud R, Launois P. Interleukin (IL)-13 is the predominant Th2 cytokine in localized cutaneous leishmaniasis lesions and renders specific CD4+ T cells unresponsive to IL-12. J Infect Dis. 2001;183:953-9 pubmed
    ..of IL-13 in most lesions from patients with American localized cutaneous leishmaniasis caused by Leishmania guyanensis. IL-13 production by peripheral blood mononuclear cells in response to specific leishmania antigens was ..
  41. Ronet C, Beverley S, Fasel N. Muco-cutaneous leishmaniasis in the New World: the ultimate subversion. Virulence. 2011;2:547-52 pubmed publisher
    ..The presence of LRV in Leishmania opens new perspectives not only in basic understanding of the intimate relation between the parasite and LRV, but also in understanding the importance of the inflammatory response in MCL patients...
  42. Rougeron V, Bañuls A, Carme B, Simon S, Couppie P, Nacher M, et al. Reproductive strategies and population structure in Leishmania: substantial amount of sex in Leishmania Viannia guyanensis. Mol Ecol. 2011;20:3116-27 pubmed publisher
    ..These results are of epidemiological relevance and suggest a major role for natural hosts and/or vectors in parasite strain diffusion across the country as compared to human hosts...
  43. Poeppl W, Burgmann H, Auer H, Mooseder G, Walochnik J. Leishmania (Viannia) guyanensis infection, Austria. Emerg Infect Dis. 2012;18:1534-5 pubmed publisher
  44. Gazola K, Ferreira A, Anacleto C, Michalick M, Andrade A, Moreira E. Cell surface carbohydrates and in vivo infectivity of glucantime-sensitive and resistant Leishmania (Viannia) guyjanensis cell lines. Parasitol Res. 2001;87:935-40 pubmed
    ..This study opens possibilities for exploring the relationship between drug susceptibility, infectivity and surface carbohydrate composition of protozoan parasites...
  45. Zamora M, Guilbride L, Sacks L, Stuart K. Phylogenetic analysis of the 5' subterminal region of isolates of Leishmania RNA virus-1. Ann Trop Med Parasitol. 2000;94:123-33 pubmed
    ..The significance and relevance of these findings in the context of the function of the 5' UTR of LRV1 as an IRES element are discussed...
  46. Muñoz G, Davies C. Leishmania panamensis transmission in the domestic environment: the results of a prospective epidemiological survey in Santander, Colombia. Biomedica. 2006;26 Suppl 1:131-44 pubmed
    ..This paper presents the results of the disease patterns in a representative population of the Opón focus, in Santander, Colombia...
  47. Bourreau E, Prévot G, Gardon J, Pradinaud R, Hasagewa H, Milon G, et al. LACK-specific CD4(+) T cells that induce gamma interferon production in patients with localized cutaneous leishmaniasis during an early stage of infection. Infect Immun. 2002;70:3122-9 pubmed
    ..source of the cytokines produced in response to these antigens were analyzed in patients infected with Leishmania guyanensis. Gamma interferon (IFN-gamma) and interleukin-10 (IL-10) were produced in response to LACK...
  48. Teixeira A, Paes M, Guerra J, Prata A, Silva Vergara M. Low efficacy of azithromycin to treat cutaneous leishmaniasis in Manaus, AM, Brazil. Rev Inst Med Trop Sao Paulo. 2007;49:235-8 pubmed
    ..The intention-treatment overall response rate was 22% and whole cure was seen in three (7.3%) of cases. Thus, azithromycin showed a low efficacy to treat cutaneous leishmaniasis in Manaus...
  49. Velez I, Carrillo L, López L, Rodríguez E, Robledo S. An epidemic outbreak of canine cutaneous leishmaniasis in Colombia caused by Leishmania braziliensis and Leishmania panamensis. Am J Trop Med Hyg. 2012;86:807-11 pubmed publisher
    ..The clinical features of the disease and the response to treatment with pentavalent antimonials observed in 72 guard dogs from the Colombian Army are described. A program for prevention and control of canine CL is also discussed...
  50. Berger F, Romary P, Brachet D, Rapp C, Imbert P, Garrabe E, et al. [Outbreak of cutaneous leishmaniasis in military population coming back from French Guiana]. Rev Epidemiol Sante Publique. 2006;54:213-21 pubmed
    ..The aims of this study were (i) to describe outbreak and (ii) to determine risk factors of cutaneous leishmaniasis...
  51. Romero I, Saravia N, Walker J. Selective action of fluoroquinolones against intracellular amastigotes of Leishmania (Viannia) panamensis in vitro. J Parasitol. 2005;91:1474-9 pubmed
    ..These findings support the potential of fluoroquinolones and derivatives as novel antileishmanials and encourage their clinical evaluation...
  52. Hu R, Kent A, Adams E, van der Veer C, Sabajo L, Mans D, et al. First case of cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis in Suriname. Am J Trop Med Hyg. 2012;86:825-7 pubmed publisher
    ..Clinicians should be aware that chronic cutaneous ulcers in patients from the Guyana region could be caused by L. braziliensis...
  53. Gil J, Hoyos C, Cimino R, Krolewiecki A, López Quiroga I, Cajal S, et al. [Role of three ELISA tests using promastigote homogenates of Leishmania braziliensis, L. amazonensis and L. guyanensis in the diagnosis of tegumentary leishmaniasis]. Medicina (B Aires). 2011;71:420-8 pubmed
    ..225). The high reactivity obtained for these ELISAs in sera of patients with mucocutaneous leishmaniasis indicates this test as an important complement in the diagnosis of the disease...
  54. Chrusciak Talhari A, Dietze R, Chrusciak Talhari C, da Silva R, Gadelha Yamashita E, de Oliveira Penna G, et al. Randomized controlled clinical trial to access efficacy and safety of miltefosine in the treatment of cutaneous leishmaniasis Caused by Leishmania (Viannia) guyanensis in Manaus, Brazil. Am J Trop Med Hyg. 2011;84:255-60 pubmed publisher
    ..05) for miltefosine and antimonial, respectively. There were no differences in cure rates between age groups within the same treatment arms. Miltefosine was safe and relatively well tolerated and cure rate was higher than antimony...
  55. Garcia A, Tellez T, Parrado R, Rojas E, Bermudez H, Dujardin J. Epidemiological monitoring of American tegumentary leishmaniasis: molecular characterization of a peridomestic transmission cycle in the Amazonian lowlands of Bolivia. Trans R Soc Trop Med Hyg. 2007;101:1208-13 pubmed
    ..This study demonstrated the use of PCR-RFLP in the identification of Leishmania in sand fly pools which could lead to the development of methods for screening large sand fly populations in Latin America...
  56. Delgado G, Puentes F, Moreno A, Patarroyo M. Flow cytometry, a useful tool for detecting the lethal effect of pentamidine on Leishmania viannia complex promastigote forms. Pharmacol Res. 2001;44:281-6 pubmed
  57. Fischer M, GomesPaes M, Reinel D, Talhari S. [Diffuse infiltration of the external ear in a 59-year-old Brazilian patient. "New world" cutaneous leishmaniasis (leishmaniasis tegumentar Americana)]. Hautarzt. 2002;53:342-6 pubmed
  58. de Oliveira Ramos Pereira L, Brandao A. An analysis of trypanosomatids kDNA minicircle by absolute dinucleotide frequency. Parasitol Int. 2013;62:397-403 pubmed publisher
    ..Using Trypanosoma rangeli and Leishmania guyanensis minicircles as example of sequence length heterogeneity, we show that dinucleotide frequency of ..
  59. Dedet J, Carme B, Desbois N, Bourdoiseau G, Lachaud L, Pratlong F. [Epidemiology of autochthonous leishmaniases in France]. Presse Med. 2013;42:1469-81 pubmed publisher
    ..In Guadeloupe Island, a few autochthonous visceral leishmaniasis cases have been reported, needing a prospective study...
  60. Cortázar T, Coombs G, Walker J. Leishmania panamensis: comparative inhibition of nuclear DNA topoisomerase II enzymes from promastigotes and human macrophages reveals anti-parasite selectivity of fluoroquinolones, flavonoids and pentamidine. Exp Parasitol. 2007;116:475-82 pubmed
    ..3-fold greater potency against the macrophage enzyme. These findings suggest that the leishmanicidal activities of certain fluoroquinolones and pentamidine may be mediated partly through TOPII inhibition...
  61. Banuls A, Jonquieres R, Guerrini F, Le Pont F, Barrera C, Espinel I, et al. Genetic analysis of leishmania parasites in Ecuador: are Leishmania (Viannia) panamensis and Leishmania (V.) Guyanensis distinct taxa?. Am J Trop Med Hyg. 1999;61:838-45 pubmed
    ..V.) panamensis and L. (V.) guyanensis correspond to distinct monophyletic lines. Population genetic analysis performed on the L. (V.) panamensis/guyanensis group favors the hypothesis of a basically clonal population structure...
  62. Walker J, Gongora R, Vasquez J, Drummelsmith J, Burchmore R, Roy G, et al. Discovery of factors linked to antimony resistance in Leishmania panamensis through differential proteome analysis. Mol Biochem Parasitol. 2012;183:166-76 pubmed publisher
    ..These data re-enforce the importance of thiol metabolism in Leishmania Sb resistance, reveal previously unrecognized steps in the mechanism(s) of Sb tolerance, and suggest a cross-talk between drug resistance, metabolism and virulence...
  63. Travi B, Arteaga L, Leon A, Adler G. Susceptibility of spiny rats (Proechimys semispinosus) to Leishmania (Viannia) panamensis and Leishmania (Leishmania) chagasi. Mem Inst Oswaldo Cruz. 2002;97:887-92 pubmed
    ..panamensis, combined with population characteristics, e.g., abundance, exploitation of degraded habitats and high reproductive rates, could make them epidemiologically suitable reservoirs...
  64. Rotureau B, Joubert M, Clyti E, Djossou F, Carme B. Leishmaniasis among gold miners, French Guiana. Emerg Infect Dis. 2006;12:1169-70 pubmed
  65. Romero G, Vinitius De Farias Guerra M, Gomes Paes M, de Oliveira Macêdo V. Comparison of cutaneous leishmaniasis due to Leishmania (Viannia) braziliensis and L. (V.) guyanensis in Brazil: clinical findings and diagnostic approach. Clin Infect Dis. 2001;32:1304-12 pubmed
    ..Our data provide substantial evidence that indicate that the disease caused by these species differs with regard to clinical presentation and diagnostic approach...
  66. Dedet J, Pratlong F, Pradinaud R, Moreau B. Delayed culture of Leishmania in skin biopsies. Trans R Soc Trop Med Hyg. 1999;93:673-4 pubmed
    ..Positive results were obtained at all seasons and for 3 different Leishmania species. The study indicates that delayed culture can yield useful results from biopsies taken in field conditions...
  67. Ro Y, Scheffter S, Patterson J. Specific in vitro cleavage of a Leishmania virus capsid-RNA-dependent RNA polymerase polyprotein by a host cysteine-like protease. J Virol. 1997;71:8983-90 pubmed
    ..From these results, we suggest that failure to detect a capsid-polymerase fusion protein produced by translational frameshifting in vivo may be due to specific proteolytic processing...
  68. Santamaría E, Ponce N, Zipa Y, Ferro C. [Presence of infected vectors of Leishmania (V.) panamensis within dwellings in two endemic foci in the foothill of the middle Magdalena valley, western Boyacá, Colombia]. Biomedica. 2006;26 Suppl 1:82-94 pubmed
    ..Age and gender distribution of cases supported a domestic transmission...
  69. Anacleto C, Abdo M, Ferreira A, Murta S, Romanha A, Fernandes A, et al. Structural and functional analysis of an amplification containing a PGPA gene in a glucantime-resistant Leishmania (Viannia) guyanensis cell line. Parasitol Res. 2003;90:110-8 pubmed
    ..V.) guyanensis. Our work indicates that, in this pathogenic New World Leishmania species, amplification of the PGPA gene is the major determinant in oxyanion resistance...
  70. Peláez R, Muskus C, Cuervo P, Marín Villa M. [Differential expression of proteins in Leishmania (Viannia) panamensis associated with mechanisms of resistance to meglumine antimoniate]. Biomedica. 2012;32:418-29 pubmed publisher
  71. Ramirez C, Díaz Toro Y, Tellez J, Castilho T, Rojas R, Ettinger N, et al. Human macrophage response to L. (Viannia) panamensis: microarray evidence for an early inflammatory response. PLoS Negl Trop Dis. 2012;6:e1866 pubmed publisher
  72. Mulvaney P, Aram G, Maggiore P, Kutzner H, Carlson J. Delay in diagnosis: trauma- and coinfection-related cutaneous leishmaniasis because of Leishmania guyanensis infection. J Cutan Pathol. 2009;36:53-60 pubmed publisher
    ..reaction (PCR) assays for infectious agents on DNA extracted from the biopsy specimens were performed, and Leishmania guyanensis was detected in all specimens...
  73. Taylor V, Muñoz D, Cedeño D, Velez I, Jones M, Robledo S. Leishmania tarentolae: utility as an in vitro model for screening of antileishmanial agents. Exp Parasitol. 2010;126:471-5 pubmed publisher
    ..L. tarentolae amastigotes offer a suitable model for the in vitro screening of compounds for antileishmanial activity...
  74. Montalvo Alvarez A, Nodarse J, Goodridge I, Fidalgo L, Marin M, Van der Auwera G, et al. Differentiation of Leishmania (Viannia) panamensis and Leishmania (V.) guyanensis using BccI for hsp70 PCR-RFLP. Trans R Soc Trop Med Hyg. 2010;104:364-7 pubmed publisher
    Leishmania panamensis and Leishmania guyanensis are two species of the subgenus Viannia that are genetically very similar...
  75. Matta N, Nogueira R, Franco A, de Souza E Souza I, Mattos M, Oliveira Neto M, et al. Leishmania (Viannia) guyanensis induces low immunologic responsiveness in leishmaniasis patients from an endemic area of the Brazilian Amazon Highland. Am J Trop Med Hyg. 2009;80:339-44 pubmed
    ..braziliensis. This finding could explain some aspects of clinical presentation of CL-Lguy, such as high tissue parasite burden and frequent resistance to therapy...
  76. Pérez Cordero J, Sánchez Suárez J, Delgado G. Use of a fluorescent stain for evaluating in vitro infection with Leishmania panamensis. Exp Parasitol. 2011;129:31-5 pubmed publisher
    ..These results support the use of SYBR® Safe as a promising tool for evaluating potential antileishmanials given its advantages over the traditional technique...
  77. Alzate J, Ramírez Pineda J, González V, Patiño E, Velez I, Jimenez Ruiz A. Leishmania (Viannia) panamensis: cloning of the histone H1 genes by representational difference analysis. Exp Parasitol. 2006;112:126-9 pubmed
    ..The gene is present in two copies that are expressed at different levels in promastigotes and also in amastigotes, which seems to be a consequence of their different 3' untranslated regions...