leishmania braziliensis

Summary

Summary: A parasitic hemoflagellate of the subgenus Leishmania viannia that infects man and animals. It causes cutaneous (LEISHMANIASIS, CUTANEOUS), diffuse cutaneous (LEISHMANIASIS, DIFFUSE CUTANEOUS), and mucocutaneous leishmaniasis (LEISHMANIASIS, MUCOCUTANEOUS) depending on the subspecies of this organism. The sandfly, Lutzomyia, is the vector. The Leishmania braziliensis complex includes the subspecies braziliensis and peruviana. Uta, a form of cutaneous leishmaniasis in the New World, is caused by the subspecies peruviana.

Top Publications

  1. Novais F, Nguyen B, Beiting D, Carvalho L, Glennie N, Passos S, et al. Human classical monocytes control the intracellular stage of Leishmania braziliensis by reactive oxygen species. J Infect Dis. 2014;209:1288-96 pubmed publisher
    b>Leishmania braziliensis are intracellular parasites that cause unique clinical forms of cutaneous leishmaniasis...
  2. Schriefer A, Guimaraes L, Machado P, Lessa M, Lessa H, Lago E, et al. Geographic clustering of leishmaniasis in northeastern Brazil. Emerg Infect Dis. 2009;15:871-6 pubmed publisher
    To determine whether disease outcomes and clades of Leishmania braziliensis genotypes are associated, we studied geographic clustering of clades and most severe disease outcomes for leishmaniasis during 1999-2003 in Corte de Pedra in ..
  3. Zauli Nascimento R, Miguel D, Yokoyama Yasunaka J, Pereira L, Pelli de Oliveira M, Ribeiro Dias F, et al. In vitro sensitivity of Leishmania (Viannia) braziliensis and Leishmania (Leishmania) amazonensis Brazilian isolates to meglumine antimoniate and amphotericin B. Trop Med Int Health. 2010;15:68-76 pubmed publisher
    ..Isolates were also uniformly susceptible in vitro to amphotericin B...
  4. Turetz M, Machado P, Ko A, Alves F, Bittencourt A, Almeida R, et al. Disseminated leishmaniasis: a new and emerging form of leishmaniasis observed in northeastern Brazil. J Infect Dis. 2002;186:1829-34 pubmed
    ..The present report describes 42 cases of DL identified between 1992 and 1998 in an area where Leishmania braziliensis transmission is endemic; 8 of the patients were prospectively diagnosed...
  5. Vitoriano Souza J, Reis A, Moreira N, Giunchetti R, Correa Oliveira R, Carneiro C. Kinetics of cell migration to the dermis and hypodermis in dogs vaccinated with antigenic compounds of Leishmania braziliensis plus saponin. Vaccine. 2008;26:3922-31 pubmed publisher
    ..Our major findings indicated that saponin adjuvant alone or combined with Leishmania braziliensis antigen induced strong local acute inflammatory reaction...
  6. de Oliveira F, Valete Rosalino C, Schubach A, Pacheco R. kDNA minicircle signatures of Leishmania (Viannia) braziliensis in oral and nasal mucosa from mucosal leishmaniasis patients. Diagn Microbiol Infect Dis. 2010;66:361-5 pubmed publisher
    ..This is the first work to report genetic typing of L. (V.) braziliensis directly from human oral and nasal mucosal lesions. ..
  7. Adaui V, Schnorbusch K, Zimic M, Gutierrez A, Decuypere S, Vanaerschot M, et al. Comparison of gene expression patterns among Leishmania braziliensis clinical isolates showing a different in vitro susceptibility to pentavalent antimony. Parasitology. 2011;138:183-93 pubmed publisher
    ..We analysed here the gene expression profile of 21 L. braziliensis clinical isolates in vitro defined as Sb(V)-resistant and -sensitive, in order to identify potential resistance markers...
  8. O Neal S, Guimaraes L, Machado P, Alcântara L, Morgan D, Passos S, et al. Influence of helminth infections on the clinical course of and immune response to Leishmania braziliensis cutaneous leishmaniasis. J Infect Dis. 2007;195:142-8 pubmed
    ..Patients coinfected with Leishmania braziliensis and helminths took longer to heal (relative hazard for healing, 0.47 [95% confidence interval, 0.26-0...
  9. Peacock C, Seeger K, Harris D, Murphy L, Ruiz J, Quail M, et al. Comparative genomic analysis of three Leishmania species that cause diverse human disease. Nat Genet. 2007;39:839-47 pubmed
    ..Here we report the sequencing of the genomes of two species of Leishmania: Leishmania infantum and Leishmania braziliensis. The comparison of these sequences with the published genome of Leishmania major reveals marked ..

More Information

Publications99

  1. Campanelli A, Roselino A, Cavassani K, Pereira M, Mortara R, Brodskyn C, et al. CD4+CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells. J Infect Dis. 2006;193:1313-22 pubmed
    ..These findings suggest that functional Treg cells accumulate at sites of Leishmania infection in humans and possibly contribute to the local control of effector T cell functions. ..
  2. Faria D, Gollob K, Barbosa J, Schriefer A, Machado P, Lessa H, et al. Decreased in situ expression of interleukin-10 receptor is correlated with the exacerbated inflammatory and cytotoxic responses observed in mucosal leishmaniasis. Infect Immun. 2005;73:7853-9 pubmed
    Human infection with Leishmania braziliensis can lead to cutaneous leishmaniasis (CL) or mucosal leishmaniasis (ML)...
  3. Soares R, Cardoso T, Barron T, Araújo M, Pimenta P, Turco S. Leishmania braziliensis: a novel mechanism in the lipophosphoglycan regulation during metacyclogenesis. Int J Parasitol. 2005;35:245-53 pubmed
    ..braziliensis makes less LPG and add 1-2 (beta1-3) glucose residues that branch off the disaccharide-phosphate repeat units of LPG. Thus, this represents a novel mechanism in the regulation of LPG structure during metacyclogenesis. ..
  4. Junqueira Pedras M, Orsini M, Castro M, Passos V, Rabello A. Antibody subclass profile against Leishmania braziliensis and Leishmania amazonensis in the diagnosis and follow-up of mucosal leishmaniasis. Diagn Microbiol Infect Dis. 2003;47:477-85 pubmed
    ..and specificities of IgG subclasses-ELISA and IgG-indirect fluorescent antibody test (IFAT) against Leishmania braziliensis (Lb) and L...
  5. Boggild A, Ramos A, Espinosa D, Valencia B, Veland N, Miranda Verastegui C, et al. Clinical and demographic stratification of test performance: a pooled analysis of five laboratory diagnostic methods for American cutaneous leishmaniasis. Am J Trop Med Hyg. 2010;83:345-50 pubmed publisher
    ..That clinical factors influence performance of non-molecular assays offers clinicians a patient-focused approach to diagnostic test selection...
  6. Castellano L, Filho D, Argiro L, Dessein H, Prata A, Dessein A, et al. Th1/Th2 immune responses are associated with active cutaneous leishmaniasis and clinical cure is associated with strong interferon-gamma production. Hum Immunol. 2009;70:383-90 pubmed publisher
  7. Ishikawa E, Silveira F, Magalhães A, Guerra júnior R, Melo M, Gomes R, et al. Genetic variation in populations of Leishmania species in Brazil. Trans R Soc Trop Med Hyg. 2002;96 Suppl 1:S111-21 pubmed
    ..Our results support the clonal population structure of Leishmania isolates and suggest that their distribution is related to the origin of the gene pool as well as to present vector and reservoir movements. ..
  8. Miranda J, Reis E, Schriefer A, Goncalves M, Reis M, Carvalho L, et al. Frequency of infection of Lutzomyia phlebotomines with Leishmania braziliensis in a Brazilian endemic area as assessed by pinpoint capture and polymerase chain reaction. Mem Inst Oswaldo Cruz. 2002;97:185-8 pubmed
    ..Such a clustering may have implications in control strategies against leishmaniasis, and reinforces the necessity of understanding the ecological and geographical factors involved in leishmanial transmission. ..
  9. Schriefer A, Schriefer A, Goes Neto A, Guimarães L, Carvalho L, Almeida R, et al. Multiclonal Leishmania braziliensis population structure and its clinical implication in a region of endemicity for American tegumentary leishmaniasis. Infect Immun. 2004;72:508-14 pubmed
    In Corte de Pedra (CP), northeastern Brazil, Leishmania braziliensis causes three distinct forms of American tegumentary leishmaniasis (ATL)...
  10. C Falcão S, de Moura T, Clarencio J, Brodskyn C, Barral A, de Oliveira C. The presence of Tregs does not preclude immunity to reinfection with Leishmania braziliensis. Int J Parasitol. 2012;42:771-80 pubmed publisher
    Leishmania spp. cause a broad spectrum of diseases collectively known as leishmaniasis. Leishmania braziliensis is the main etiological agent of American cutaneous leishmaniasis and mucocutaneous leishmaniasis...
  11. Friedrich K, Vieira F, Porrozzi R, Marchevsky R, Miekeley N, Grimaldi G, et al. Disposition of antimony in rhesus monkeys infected with Leishmania braziliensis and treated with meglumine antimoniate. J Toxicol Environ Health A. 2012;75:63-75 pubmed publisher
    Antimony (Sb) disposition and toxicity was evaluated in Leishmania braziliensis-infected monkeys (Macaca mulatta) treated with a 21-d course of low (LOW) or standard (STD) meglumine antimoniate (MA) dosage regimens (5 or 20 mg Sb(V)/kg ..
  12. Velez I, Carrillo L, López L, Rodríguez E, Robledo S. An epidemic outbreak of canine cutaneous leishmaniasis in Colombia caused by Leishmania braziliensis and Leishmania panamensis. Am J Trop Med Hyg. 2012;86:807-11 pubmed publisher
    ..This work describes an epidemic outbreak of canine CL caused by Leishmania braziliensis and Leishmania panamensis in Colombia, South America...
  13. Carvalho M, de Andrade A, Fontes C, Hueb M, de Oliveira Silva S, Melo M. Leishmania (Viannia) braziliensis is the prevalent species infecting patients with tegumentary leishmaniasis from Mato Grosso State, Brazil. Acta Trop. 2006;98:277-85 pubmed
    ..V.) braziliensis samples from Mato Grosso. The importance of these results concerning the taxonomic status of New World Leishmania, and their implications for both clinical and epidemiological data is discussed. ..
  14. Bensoussan E, Nasereddin A, Jonas F, Schnur L, Jaffe C. Comparison of PCR assays for diagnosis of cutaneous leishmaniasis. J Clin Microbiol. 2006;44:1435-9 pubmed
    ..9%), Leishmania tropica (47.2%), and the Leishmania braziliensis complex (1.9%)...
  15. Vendrame C, Souza L, Carvalho M, Salgado K, Carvalho E, Goto H. Insulin-like growth factor-I induced and constitutive arginase activity differs among isolates of Leishmania derived from patients with diverse clinical forms of Leishmania braziliensis infection. Trans R Soc Trop Med Hyg. 2010;104:566-8 pubmed publisher
    ..Differences in arginase activity may influence disease outcomes such as evolution to mucosal lesion in patients with L. (V.) braziliensis infection. ..
  16. Antonelli L, Dutra W, Almeida R, Bacellar O, Gollob K. Antigen specific correlations of cellular immune responses in human leishmaniasis suggests mechanisms for immunoregulation. Clin Exp Immunol. 2004;136:341-8 pubmed
  17. Fakhar M, Motazedian M, Daly D, Lowe C, Kemp S, Noyes H. An integrated pipeline for the development of novel panels of mapped microsatellite markers for Leishmania donovani complex, Leishmania braziliensis and Leishmania major. Parasitology. 2008;135:567-74 pubmed publisher
    ..The limit of detection was approximately 1.6 parasite equivalents. However, only 6/56 DNA from slides stored at ambient temperature for over 6 months gave positive PCR results. ..
  18. Tavares N, Silva R, Costa D, Pitombo M, Fukutani K, Miranda J, et al. Lutzomyia longipalpis saliva or salivary protein LJM19 protects against Leishmania braziliensis and the saliva of its vector, Lutzomyia intermedia. PLoS Negl Trop Dis. 2011;5:e1169 pubmed publisher
    ..However, immunization with Lutzomyia intermedia saliva did not protect mice against Leishmania braziliensis plus Lu. intermedia saliva. In the present study, we have studied whether the immunization with Lu...
  19. Carmelo E, Martinez E, González A, Piñero J, Patarroyo M, del Castillo A, et al. Antigenicity of Leishmania braziliensis histone H1 during cutaneous leishmaniasis: localization of antigenic determinants. Clin Diagn Lab Immunol. 2002;9:808-11 pubmed
    The humoral immune response against Leishmania braziliensis histone H1 by patients with cutaneous leishmaniasis is described...
  20. Salomon O, Acardi S, Liotta D, Fernandez M, Lestani E, López D, et al. Epidemiological aspects of cutaneous leishmaniasis in the Iguazú falls area of Argentina. Acta Trop. 2009;109:5-11 pubmed publisher
    ..In addition, the risk of periurban transmission seems likely, and this is discussed within the framework of surveillance and prevention strategies...
  21. Tonui W, Titus R. Cross-protection against Leishmania donovani but not L. Braziliensis caused by vaccination with L. Major soluble promastigote exogenous antigens in BALB/c mice. Am J Trop Med Hyg. 2007;76:579-84 pubmed
    ..Such mice were protected against L. donovani but not L. braziliensis infection. Leishmania braziliensis-infected mice developed lesions that were not significantly different from those of controls and that ..
  22. Soares R, Margonari C, Secundino N, Macedo M, da Costa S, Rangel E, et al. Differential midgut attachment of Leishmania (Viannia) braziliensis in the sand flies Lutzomyia (Nyssomyia) whitmani and Lutzomyia (Nyssomyia) intermedia. J Biomed Biotechnol. 2010;2010:439174 pubmed publisher
    ..whitmani than in L. intermedia. The epidemiological relevance of L. whitmani as a vector of American Cutaneous Leishmaniasis (ACL) in Brazil is discussed. ..
  23. Faria D, Souza P, Durães F, Carvalho E, Gollob K, Machado P, et al. Recruitment of CD8(+) T cells expressing granzyme A is associated with lesion progression in human cutaneous leishmaniasis. Parasite Immunol. 2009;31:432-9 pubmed publisher
    Human infection with Leishmania braziliensis leads to the establishment of cutaneous leishmaniasis (CL), characterized by the appearance of skin lesions that progress from nonulcerated to ulcerated forms...
  24. Martins L, Alexandrino A, Guimarães G. Detection of Leishmania braziliensis DNA in American tegumentary leishmaniasis patients. Rev Saude Publica. 2010;44:571-4 pubmed
    ..The tests used primers specific for the kinetoplast mini-circle DNA (kDNA) of Leishmania braziliensis, a species circulating in Pernambuco, which amplify a 750 base pair target sequence...
  25. Follador I, Araujo C, Bacellar O, Araújo C, Carvalho L, Almeida R, et al. Epidemiologic and immunologic findings for the subclinical form of Leishmania braziliensis infection. Clin Infect Dis. 2002;34:E54-8 pubmed
    The epidemiologic and immunologic findings for 104 subjects with subclinical Leishmania braziliensis infection were compared with those for 29 patients with cutaneous leishmaniasis (CL) from the same area of endemicity...
  26. Giudice A, Camada I, Leopoldo P, Pereira J, Riley L, Wilson M, et al. Resistance of Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensis to nitric oxide correlates with disease severity in Tegumentary Leishmaniasis. BMC Infect Dis. 2007;7:7 pubmed
    ..Nitric oxide (NO*) plays a pivotal role as a leishmanicidal agent in mouse macrophages. NO* resistant Escherichia coli and Mycobacterium tuberculosis have been associated with a severe outcome of these diseases...
  27. Ram rez C, Requena J, Puerta C. Identification of the HSP70-II gene in Leishmania braziliensis HSP70 locus: genomic organization and UTRs characterization. Parasit Vectors. 2011;4:166 pubmed publisher
    ..braziliensis, complementing the information available in the GeneDB genome database for this species. L. braziliensis HSP70 gene regulation does not seem to operate by mRNA stabilization as occurs in other Leishmania species...
  28. Da Cruz A, Bertho A, Oliveira Neto M, Coutinho S. Flow cytometric analysis of cellular infiltrate from American tegumentary leishmaniasis lesions. Br J Dermatol. 2005;153:537-43 pubmed
    ..CD4+ and CD8+ T lymphocytes play different roles in the outcome of leishmaniasis. However, T-cell distribution in lesions shows significant variability in in situ immunocytochemical studies...
  29. Soto J, Rea J, Balderrama M, Toledo J, Soto P, Valda L, et al. Efficacy of miltefosine for Bolivian cutaneous leishmaniasis. Am J Trop Med Hyg. 2008;78:210-1 pubmed
    ..intramuscular antimony (20 mg/kg/d for 20 days) in the treatment of cutaneous leishmaniasis caused by Leishmania braziliensis in Palos Blancos, Bolivia...
  30. Depledge D, Evans K, Ivens A, Aziz N, Maroof A, Kaye P, et al. Comparative expression profiling of Leishmania: modulation in gene expression between species and in different host genetic backgrounds. PLoS Negl Trop Dis. 2009;3:e476 pubmed publisher
    ..braziliensis. It is not yet known how many of these genes are expressed in the disease-promoting intracellular amastigotes of these species or whether genes conserved between the species are differentially expressed in the host...
  31. Mendes Aguiar C, Gomes Silva A, Nunes E, Pereira Carvalho R, Nogueira R, Oliveira Neto M, et al. The skin homing receptor cutaneous leucocyte-associated antigen (CLA) is up-regulated by Leishmania antigens in T lymphocytes during active cutaneous leishmaniasis. Clin Exp Immunol. 2009;157:377-84 pubmed publisher
  32. Indiani de Oliveira C, Teixeira M, Teixeira C, Ramos de Jesus J, Bomura Rosato A, Santa da Silva J, et al. Leishmania braziliensis isolates differing at the genome level display distinctive features in BALB/c mice. Microbes Infect. 2004;6:977-84 pubmed
    b>Leishmania braziliensis is the species responsible for the majority of cases of human cutaneous leishmaniasis in Brazil. In the present study, L...
  33. Gomes Silva A, de Cássia Bittar R, Dos Santos Nogueira R, Amato V, da Silva Mattos M, Oliveira Neto M, et al. Can interferon-gamma and interleukin-10 balance be associated with severity of human Leishmania (Viannia) braziliensis infection?. Clin Exp Immunol. 2007;149:440-4 pubmed
    ..Conversely, lower IFN-gamma/IL-10 balance observed in CCL, SH and ASY individuals can represent a better-modulated immune response associated with a favourable prognosis...
  34. Matrangolo F, Liarte D, Andrade L, de Melo M, Andrade J, Ferreira R, et al. Comparative proteomic analysis of antimony-resistant and -susceptible Leishmania braziliensis and Leishmania infantum chagasi lines. Mol Biochem Parasitol. 2013;190:63-75 pubmed publisher
    ..A comparative proteomic analysis of antimony-susceptible and antimony-resistant Leishmania braziliensis (LbSbR) and Leishmania infantum chagasi (LcSbR) lines was carried out using two-dimensional gel ..
  35. Dias F, Ruiz J, Lopes W, Squina F, Renzi A, Cruz A, et al. Organization of H locus conserved repeats in Leishmania (Viannia) braziliensis correlates with lack of gene amplification and drug resistance. Parasitol Res. 2007;101:667-76 pubmed
    ..The absence of amplicons in L. braziliensis suggests that this species may not favour extra-chromosomal gene amplification as a source of phenotypic heterogeneity and fitness maintenance in changing environments...
  36. Maretti Mira A, de Pinho Rodrigues K, de Oliveira Neto M, Pirmez C, Craft N. MMP-9 activity is induced by Leishmania braziliensis infection and correlates with mucosal leishmaniasis. Acta Trop. 2011;119:160-4 pubmed publisher
    Infection of humans with Leishmania braziliensis typically results in localized cutaneous leishmaniasis (LCL). Rarely, after months or years of apparent clinical cure, some patients develop the destructive mucosal leishmaniasis (ML)...
  37. Peterson A, Shaw J. Lutzomyia vectors for cutaneous leishmaniasis in Southern Brazil: ecological niche models, predicted geographic distributions, and climate change effects. Int J Parasitol. 2003;33:919-31 pubmed
    ..More generally, this technique offers the possibility of new views into the distributional ecology of disease, vector, and reservoir species...
  38. Machado P, Ampuero J, Guimaraes L, Villasboas L, Rocha A, Schriefer A, et al. Miltefosine in the treatment of cutaneous leishmaniasis caused by Leishmania braziliensis in Brazil: a randomized and controlled trial. PLoS Negl Trop Dis. 2010;4:e912 pubmed publisher
    ..Cutaneous leishmaniasis (CL) is treated with parenteral drugs for decades with decreasing rate cures. Miltefosine is an oral medication with anti-leishmania activity and may increase the cure rates and improve compliance...
  39. Jackson A, Vaughan S, Gull K. Comparative genomics and concerted evolution of beta-tubulin paralogs in Leishmania spp. BMC Genomics. 2006;7:137 pubmed
    ..infantum and L. braziliensis. Untranscribed regions and coding sequences for each isoform were compared within and between species in relation to the known diversity of beta-tubulin transcripts in Leishmania spp...
  40. Gonçalves G, Fernandes A, Souza R, Cardoso J, de Oliveira Silva F, Maciel F, et al. Activity of a paromomycin hydrophilic formulation for topical treatment of infections by Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensis. Acta Trop. 2005;93:161-7 pubmed
    ..These results suggest that this formulation could be suitable for clinical studies and may represent an alternative novel formulation for topical treatment of CL...
  41. Carvalho L, Passos S, Dutra W, Soto M, Alonso C, Gollob K, et al. Effect of LACK and KMP11 on IFN-gamma production by peripheral blood mononuclear cells from cutaneous and mucosal leishmaniasis patients. Scand J Immunol. 2005;61:337-42 pubmed
    ..However, in some clinical conditions, as demonstrated for ML, these molecules are not able to suppress the IFN-gamma response, even inducing IL-10 production...
  42. Falqueto A, Sessa P, Ferreira A, Vieira V, Santos C, Varejão J, et al. Epidemiological and clinical features of Leishmania (Viannia) braziliensis American cutaneous and mucocutaneous leishmaniasis in the State of Espírito Santo, Brazil. Mem Inst Oswaldo Cruz. 2003;98:1003-10 pubmed
  43. Morais Teixeira E, Carvalho A, Costa J, Duarte S, Mendonça J, Boechat N, et al. In vitro and in vivo activity of meglumine antimoniate produced at Farmanguinhos-Fiocruz, Brazil, against Leishmania (Leishmania) amazonensis, L (L.) chagasi and L (Viannia) braziliensis. Mem Inst Oswaldo Cruz. 2008;103:358-62 pubmed
    ..The meglumine antimoniate produced by Farmanguinhos was as effective as the reference drug, Glucantime-Aventis, against three species of Leishmania that are of medical importance in Brazil...
  44. Brito M, Andrade M, Mendonça M, Silva C, Almeida E, Lima B, et al. Species diversity of Leishmania (Viannia) parasites circulating in an endemic area for cutaneous leishmaniasis located in the Atlantic rainforest region of northeastern Brazil. Trop Med Int Health. 2009;14:1278-86 pubmed publisher
  45. De Lima H, De Guglielmo Z, Rodriguez A, Convit J, Rodriguez N. Cotton rats (Sigmodon hispidus) and black rats (Rattus rattus) as possible reservoirs of Leishmania spp. in Lara State, Venezuela. Mem Inst Oswaldo Cruz. 2002;97:169-74 pubmed
    ..braziliensis in two others. The latter species was also identified in the single positive specimen of S. hispidus. The results suggested both species of animals as possible reservoirs of Leishmania sp...
  46. de Oliveira Camera P, Junger J, do Espírito Santo Silva Pires F, Mattos M, Oliveira Neto M, Fernandes O, et al. Haematogenous dissemination of Leishmania (Viannia) braziliensis in human American tegumentary leishmaniasis. Trans R Soc Trop Med Hyg. 2006;100:1112-7 pubmed
    ..These data suggest that persistence of parasites within the host may last for many years and, rather than being a risk factor, might be important in maintaining the protective response in those living in endemic areas...
  47. de Moura T, Oliveira F, Novais F, Miranda J, Clarencio J, Follador I, et al. Enhanced Leishmania braziliensis infection following pre-exposure to sandfly saliva. PLoS Negl Trop Dis. 2007;1:e84 pubmed
    ..study, we have studied the immune response against Lutzomyia intermedia saliva, the main vector of Leishmania braziliensis in Brazil, and the effects of saliva pre-exposure on L...
  48. Azevedo Pereira R, Pereira M, Oliveria Junior F, Brazil R, Côrtes L, Madeira M, et al. Heparin binding proteins from Leishmania (Viannia) braziliensis promastigotes. Vet Parasitol. 2007;145:234-9 pubmed
    ..V.) braziliensis with a suggestion of its biological activity in the interaction of Leishmania with Lutzomyia gut cells, which maybe a crucial step during this parasite's life cycle...
  49. Menezes M, Costa D, Clarencio J, Miranda J, Barral A, Barral Netto M, et al. Immunomodulation of human monocytes following exposure to Lutzomyia intermedia saliva. BMC Immunol. 2008;9:12 pubmed publisher
    ..we evaluated the effects of salivary gland sonicate (SGS) of Lutzomyia intermedia, the natural vector of Leishmania braziliensis, on monocytes obtained from the peripheral blood mononuclear cells (PBMC) of healthy volunteers...
  50. Ramasawmy R, Menezes E, Magalhaes A, Oliveira J, Castellucci L, Almeida R, et al. The -2518bp promoter polymorphism at CCL2/MCP1 influences susceptibility to mucosal but not localized cutaneous leishmaniasis in Brazil. Infect Genet Evol. 2010;10:607-13 pubmed publisher
    Mucosal leishmaniasis (ML) follows localized cutaneous leishmaniasis (CL) caused by Leishmania braziliensis. Proinflammatory responses mediate CL self-healing but are exaggerated in ML...
  51. Brandão Filho S, Shaw J. Molecular tools versus parasite isolation for evaluating the hosts of Leishmania braziliensis. Trends Parasitol. 2006;22:500-1; author reply 501-2 pubmed
  52. de Souza Neto S, Carneiro C, Vieira L, Afonso L. Leishmania braziliensis: partial control of experimental infection by interleukin-12 p40 deficient mice. Mem Inst Oswaldo Cruz. 2004;99:289-94 pubmed
    ..Furthermore, as opposed to previous reports on L. major-infected animals, no switch to a Th2 response was observed in IL-12p40 -/- infected with L. braziliensis...
  53. Sampaio M, Barbosa A, Este M, Pirmez C, Bello A, Traub Cseko Y. A 245kb mini-chromosome impacts on Leishmania braziliensis infection and survival. Biochem Biophys Res Commun. 2009;382:74-8 pubmed publisher
  54. Miguel D, Zauli Nascimento R, Yokoyama Yasunaka J, Katz S, Barbiéri C, Uliana S. Tamoxifen as a potential antileishmanial agent: efficacy in the treatment of Leishmania braziliensis and Leishmania chagasi infections. J Antimicrob Chemother. 2009;63:365-8 pubmed publisher
    The aim of this study was to evaluate the efficacy of tamoxifen in vivo in experimental models of cutaneous (CL) and visceral leishmaniasis (VL) caused by Leishmania braziliensis and Leishmania chagasi, respectively.
  55. Salay G, Dorta M, Santos N, Mortara R, Brodskyn C, Oliveira C, et al. Testing of four Leishmania vaccine candidates in a mouse model of infection with Leishmania (Viannia) braziliensis, the main causative agent of cutaneous leishmaniasis in the New World. Clin Vaccine Immunol. 2007;14:1173-81 pubmed
    ..V.) braziliensis, the main causative agent of cutaneous leishmaniasis in the New World, should be redirected toward distinct antigens or different vaccination strategies...
  56. Romero G, Guerra M, Paes M, Macedo V. Comparison of cutaneous leishmaniasis due to Leishmania (Viannia) braziliensis and L. (V.) guyanensis in Brazil: therapeutic response to meglumine antimoniate. Am J Trop Med Hyg. 2001;65:456-65 pubmed
    ..We concluded that Leishmania species constitute an important factor in predicting the outcome of cutaneous leishmaniasis treated with a pentavalent antimonial...
  57. Solomon M, Baum S, Barzilai A, Scope A, Trau H, Schwartz E. Liposomal amphotericin B in comparison to sodium stibogluconate for cutaneous infection due to Leishmania braziliensis. J Am Acad Dermatol. 2007;56:612-6 pubmed
    ..In this study, we assessed liposomal amphotericin B (AmBisome) as an alternative treatment for cutaneous L (V.) braziliensis infection...
  58. Rocha F, Schleicher U, Mattner J, Alber G, Bogdan C. Cytokines, signaling pathways, and effector molecules required for the control of Leishmania (Viannia) braziliensis in mice. Infect Immun. 2007;75:3823-32 pubmed
    ..These results not only define essential components of a protective immune response to L. braziliensis but also illustrate that the requirements for the control of cutaneous leishmaniasis vary between different parasite species...
  59. Tuon F, Gomes Silva A, Da Cruz A, Duarte M, Neto V, Amato V. Local immunological factors associated with recurrence of mucosal leishmaniasis. Clin Immunol. 2008;128:442-6 pubmed publisher
    ..These data suggest that exacerbated CD8(+) activity, in addition to a poor regulatory response, could underlie an unfavorable fate with regard to ML. These markers may be useful for predicting the prognosis of ML in lesion studies...
  60. Adaui V, Maes I, Huyse T, Van den Broeck F, Talledo M, Kuhls K, et al. Multilocus genotyping reveals a polyphyletic pattern among naturally antimony-resistant Leishmania braziliensis isolates from Peru. Infect Genet Evol. 2011;11:1873-80 pubmed publisher
    ..leishmaniasis and its link with treatment outcome, we analyzed the population structure of 24 Peruvian Leishmania braziliensis clinical isolates with known in vitro antimony susceptibility and clinical phenotype by multilocus ..
  61. Romero G, Ishikawa E, Cupolillo E, Toaldo C, Guerra M, Paes M, et al. The rarity of infection with Leishmania (Viannia) braziliensis among patients from the Manaus region of Amazonas state, Brazil, who have cutaneous leishmaniasis. Ann Trop Med Parasitol. 2002;96:131-6 pubmed
    ..V.) guyanensis. In the Manaus region, therefore, almost all human cutaneous leishmaniasis is the result of infection with L. (V.) guyanensis, and L. ( V.) braziliensis is a relatively rare cause of the disease...
  62. Guimarães L, Machado P, Lago E, Morgan D, Schriefer A, Bacellar O, et al. Atypical manifestations of tegumentary leishmaniasis in a transmission area of Leishmania braziliensis in the state of Bahia, Brazil. Trans R Soc Trop Med Hyg. 2009;103:712-5 pubmed publisher
    ..Thirteen cases healed with amphotericin B, introduced after failure of three or more courses of antimony, suggesting that amphotericin B should be considered as the drug of choice for all patients diagnosed with atypical ATL...
  63. Ogg M, Carrion R, Botelho A, Mayrink W, Correa Oliveira R, Patterson J. Short report: quantification of leishmaniavirus RNA in clinical samples and its possible role in pathogenesis. Am J Trop Med Hyg. 2003;69:309-13 pubmed
    ..RNA virus that infects the protozoa Leishmania and has been identified in numerous strains of Leishmania braziliensis and L. braziliensis guyanensis...
  64. Vargas Inchaustegui D, Hogg A, Tulliano G, Llanos Cuentas A, Arevalo J, Endsley J, et al. CXCL10 production by human monocytes in response to Leishmania braziliensis infection. Infect Immun. 2010;78:301-8 pubmed publisher
    ..Our results suggest that, following L. braziliensis infection, the production of multiple inflammatory mediators by the host may contribute to disease severity by increasing cellular recruitment...
  65. Machado P, Rosa M, Costa D, Mignac M, Silva J, Schriefer A, et al. Reappraisal of the immunopathogenesis of disseminated leishmaniasis: in situ and systemic immune response. Trans R Soc Trop Med Hyg. 2011;105:438-44 pubmed publisher
    Disseminated leishmaniasis (DL) is an emerging form of Leishmania braziliensis infection characterised by multiple cutaneous lesions on different parts of the body and a high rate of mucosal involvement...
  66. Azeredo Coutinho R, Mendonça S, Callahan H, Portal A, Max G. Sensitivity of Leishmania braziliensis promastigotes to meglumine antimoniate (glucantime) is higher than that of other Leishmania species and correlates with response to therapy in American tegumentary leishmaniasis. J Parasitol. 2007;93:688-93 pubmed
    ..b>Leishmania braziliensis promastigotes were significantly more sensitive than those belonging to other species...
  67. Shapiro J, da Costa Lima Junior M, Dorval M, de Oliveira França A, Cepa Matos M, Bordignon M. First record of Leishmania braziliensis presence detected in bats, Mato Grosso do Sul, southwest Brazil. Acta Trop. 2013;128:171-4 pubmed publisher
  68. Gontijo C, da Silva E, De Fuccio M, de Sousa M, Pacheco R, Dias E, et al. Epidemiological studies of an outbreak of cutaneous leishmaniasis in the Rio Jequitinhonha Valley, Minas Gerais, Brazil. Acta Trop. 2002;81:143-50 pubmed
    ..Four samples from human and three from canine cases were isolated and characterised by PCR and isoenzymes as being Leishmania (Viannia) braziliensis. The peridomiciliary nature of the disease is discussed...
  69. de Moura T, Novais F, Oliveira F, Clarencio J, Noronha A, Barral A, et al. Toward a novel experimental model of infection to study American cutaneous leishmaniasis caused by Leishmania braziliensis. Infect Immun. 2005;73:5827-34 pubmed
    Leishmania spp. cause a broad spectrum of diseases collectively known as leishmaniasis. Leishmania braziliensis is the main etiological agent of American cutaneous leishmaniasis (ACL) and mucocutaneous leishmaniasis...
  70. Oliveira J, Novais F, de Oliveira C, da Cruz Junior A, Campos L, da Rocha A, et al. Polymerase chain reaction (PCR) is highly sensitive for diagnosis of mucosal leishmaniasis. Acta Trop. 2005;94:55-9 pubmed
    ..reaction (PCR) for diagnosis of mucosal leishmaniasis (ML) in an endemic area in Acre, Brazil, where Leishmania braziliensis is present. Leishmania DNA was detected 34 of 35 cases, yielding a positivity rate of 97...
  71. Assis R, Ibraim I, Noronha F, Turco S, Soares R. Glycoinositolphospholipids from Leishmania braziliensis and L. infantum: modulation of innate immune system and variations in carbohydrate structure. PLoS Negl Trop Dis. 2012;6:e1543 pubmed publisher
    ..In conclusion, there are major differences in the structure and composition of GIPLs from L. braziliensis and L. infantum. Also, GIPLs are important inhibitory molecules during the interaction with macrophages...
  72. Cuervo P, Saboia Vahia L, Costa Silva Filho F, Fernandes O, Cupolillo E, de Jesus J. A zymographic study of metalloprotease activities in extracts and extracellular secretions of Leishmania (Viannia) braziliensis strains. Parasitology. 2006;132:177-85 pubmed
    ..Distinct profiles of metalloproteases were observed among the studied L. (V.) braziliensis strains. Differences among the microorganisms might be related to the geographical origin of the strains and/or to the clinical presentation...
  73. Ferreira M, Roselino A, Nascimento M, Aires J, Figueiredo J. Sensitivity of an immunoenzymatic test for detection of anti-L. brasiliensis antibodies compared to other tests used for the diagnosis of American cutaneous leishmaniasis. Rev Inst Med Trop Sao Paulo. 2006;48:215-7 pubmed
    ..an immunoenzymatic test (ELISA) for the detection of IgG in the serum of patients with ACL using a crude Leishmania braziliensis antigen, the results obtained were compared to those of other tests routinely used for the diagnosis...
  74. Gamboa D, Torres K, De Doncker S, Zimic M, Arevalo J, Dujardin J. Evaluation of an in vitro and in vivo model for experimental infection with Leishmania (Viannia) braziliensis and L. (V.) peruviana. Parasitology. 2008;135:319-26 pubmed
    ..However, our data open new perspectives for understanding the process of speciation in Leishmania and its implications in terms of pathogenicity...
  75. Rougeron V, de Meeus T, Hide M, Waleckx E, Bermudez H, Arevalo J, et al. Extreme inbreeding in Leishmania braziliensis. Proc Natl Acad Sci U S A. 2009;106:10224-9 pubmed publisher
    Leishmania species of the subgenus Viannia and especially Leishmania braziliensis are responsible for a large proportion of New World leishmaniasis cases...
  76. Newlove T, Guimaraes L, Morgan D, Alcântara L, Glesby M, Carvalho E, et al. Antihelminthic therapy and antimony in cutaneous leishmaniasis: a randomized, double-blind, placebo-controlled trial in patients co-infected with helminths and Leishmania braziliensis. Am J Trop Med Hyg. 2011;84:551-5 pubmed publisher
    ..and are associated with delayed healing time of patients with cutaneous leishmaniasis (CL) caused by Leishmania braziliensis. We conducted a randomized, double-blind, placebo-controlled clinical trial to examine the role of early ..
  77. Carmelo E, Zurita A, Martinez E, Valladares B. The sera from individuals suffering from cutaneous leishmaniasis due to Leishmania brazilensis present antibodies against parasitic conserved proteins, but not their human counterparts. Parasite. 2006;13:231-6 pubmed
    ..we investigate whether there is any relationship between the recognition of some conserved proteins from leishmania braziliensis by individuals suffering from cutaneous (CL) and mucocutaneous (MCL) leishmaniasis, and the recognition ..
  78. Marcelino A, Ferreira E, Avendanha J, Costa C, Chiarelli D, Almeida G, et al. Molecular detection of Leishmania braziliensis in Rattus norvegicus in an area endemic for cutaneous leishmaniasis in Brazil. Vet Parasitol. 2011;183:54-8 pubmed publisher
    ..51% (19/29) of the positive animals were infected by parasites belonging to the Leishmania braziliensis complex. The identification of L. braziliensis DNA in R...
  79. Lanfranco M, Loayza Muro R, Clark D, Núñez R, Zavaleta A, Jimenez M, et al. Expression and substrate specificity of a recombinant cysteine proteinase B of Leishmania braziliensis. Mol Biochem Parasitol. 2008;161:91-100 pubmed publisher
    ..In this study we have expressed, isolated and characterized for the first time a recombinant CPB from Leishmania braziliensis, the causative agent of mucocutaneous leishmaniosis...
  80. Gil J, Hoyos C, Cimino R, Krolewiecki A, López Quiroga I, Cajal S, et al. [Role of three ELISA tests using promastigote homogenates of Leishmania braziliensis, L. amazonensis and L. guyanensis in the diagnosis of tegumentary leishmaniasis]. Medicina (B Aires). 2011;71:420-8 pubmed
    ..225). The high reactivity obtained for these ELISAs in sera of patients with mucocutaneous leishmaniasis indicates this test as an important complement in the diagnosis of the disease...
  81. Lima A, Elias C, Souza J, Santos A, Dutra P. Dissimilar peptidase production by avirulent and virulent promastigotes of Leishmania braziliensis: inference on the parasite proliferation and interaction with macrophages. Parasitology. 2009;136:1179-91 pubmed publisher
    ..paper, we have analysed the cellular and extracellular proteolytic activity profiles in 2 distinct Leishmania braziliensis strains: a recently isolated (virulent) and a laboratory-adapted (avirulent) strain...
  82. Sánchez Cañete M, Carvalho L, Pérez Victoria F, Gamarro F, Castanys S. Low plasma membrane expression of the miltefosine transport complex renders Leishmania braziliensis refractory to the drug. Antimicrob Agents Chemother. 2009;53:1305-13 pubmed publisher
    ..have suggested that MLF shows significantly less efficiency against the cutaneous leishmaniasis caused by Leishmania braziliensis. In this work, we have determined the cellular and molecular basis for the natural MLF resistance ..
  83. Carregaro V, Costa D, Brodskyn C, Barral A, Barral Netto M, Cunha F, et al. Dual effect of Lutzomyia longipalpis saliva on Leishmania braziliensis infection is mediated by distinct saliva-induced cellular recruitment into BALB/c mice ear. BMC Microbiol. 2013;13:102 pubmed publisher
    ..In this study, we investigated the initial inflammatory leucocyte composition induced by one or three inocula of salivary gland extract (SGE) from Lutzomyia longipalpis in the presence or absence of Leishmania braziliensis.
  84. de Moura T, Oliveira F, Carneiro M, Miranda J, Clarencio J, Barral Netto M, et al. Functional transcriptomics of wild-caught Lutzomyia intermedia salivary glands: identification of a protective salivary protein against Leishmania braziliensis infection. PLoS Negl Trop Dis. 2013;7:e2242 pubmed publisher
    ..Leishmania major infection, while immunity to Lutzomyia intermedia SG homogenate exacerbated experimental Leishmania braziliensis infection. In humans, antibodies to Lu. intermedia saliva are associated with risk of acquiring L...
  85. Grenfell R, Marques da Silva E, Souza Testasicca M, Coelho E, Fernandes A, Afonso L, et al. Antigenic extracts of Leishmania braziliensis and Leishmania amazonensis associated with saponin partially protects BALB/c mice against Leishmania chagasi infection by suppressing IL-10 and IL-4 production. Mem Inst Oswaldo Cruz. 2010;105:818-22 pubmed
    ..These immunogenic preparations were composed of Leishmania amazonensis or Leishmania braziliensis antigenic extracts in association with saponin adjuvant...
  86. Weinkopff T, Mariotto A, Simon G, Hauyon La Torre Y, Auderset F, Schuster S, et al. Role of Toll-like receptor 9 signaling in experimental Leishmania braziliensis infection. Infect Immun. 2013;81:1575-84 pubmed publisher
    Infection with Leishmania braziliensis causes cutaneous or mucocutaneous leishmaniasis in humans. Toll-like receptor 9 (TLR9) expression has been found in granulomas of lesions in L. braziliensis-infected individuals. L...
  87. Gamboa D, van Eys G, Victoir K, Torres K, Adaui V, Arevalo J, et al. Putative markers of infective life stages in Leishmania (Viannia) braziliensis. Parasitology. 2007;134:1689-98 pubmed
    ..The oligopeptidase b showed a higher expression in amastigotes. Two genes, glucose-6-phosphate dehydrogenase and a serine/threonine protein kinase, were found to be similarly expressed in the different biological samples...
  88. Carvalho L, Pearce E, Scott P. Functional dichotomy of dendritic cells following interaction with Leishmania braziliensis: infected cells produce high levels of TNF-alpha, whereas bystander dendritic cells are activated to promote T cell responses. J Immunol. 2008;181:6473-80 pubmed
    b>Leishmania braziliensis infections are often associated with exaggerated immune responses that can sometimes lead to severe disease associated with high levels of IFN-gamma and TNF-alpha...
  89. Baptista C, Schubach A, Madeira M, Leal C, Pires M, Oliveira F, et al. Leishmania (Viannia) braziliensis genotypes identified in lesions of patients with atypical or typical manifestations of tegumentary leishmaniasis: evaluation by two molecular markers. Exp Parasitol. 2009;121:317-22 pubmed publisher
    ..V.) braziliensis circulating in the State of Rio de Janeiro and demonstrate the useful application of these molecular markers in genetics variability studies...
  90. Vargas Inchaustegui D, Tai W, Xin L, Hogg A, Corry D, Soong L. Distinct roles for MyD88 and Toll-like receptor 2 during Leishmania braziliensis infection in mice. Infect Immun. 2009;77:2948-56 pubmed publisher
    We have previously reported that Leishmania braziliensis infection can activate murine dendritic cells (DCs) and upregulate signaling pathways that are essential for the initiation of innate immunity...