plakortis

Summary

Summary: A genus of SPONGES in the family Plakinidae, with the skeleton formed by small diactine (and some triactine) needle-like terminations.

Top Publications

  1. Fattorusso C, Campiani G, Catalanotti B, Persico M, Basilico N, Parapini S, et al. Endoperoxide derivatives from marine organisms: 1,2-dioxanes of the plakortin family as novel antimalarial agents. J Med Chem. 2006;49:7088-94 pubmed
    Plakortin (1) is a remarkably simple 1,2-dioxane derivative, extracted from the marine sponge Plakortis simplex, showing a submicromolar activity against chloroquine-resistant strains of Plasmodium falciparum...
  2. Ankisetty S, Gochfeld D, Diaz M, Khan S, Slattery M. Chemical constituents of the deep reef caribbean sponges Plakortis angulospiculatus and Plakortis halichondrioides and their anti-inflammatory activities. J Nat Prod. 2010;73:1494-8 pubmed publisher
    Chemical investigations of two collections of the deep reef Caribbean sponge Plakortis angulospiculatus resulted in the isolation of a new compound (1) along with the known compound spiculoic acid B (2) belonging to the spiculoic acid ..
  3. Davis R, Duffy S, Fletcher S, Avery V, Quinn R. Thiaplakortones A-D: antimalarial thiazine alkaloids from the Australian marine sponge Plakortis lita. J Org Chem. 2013;78:9608-13 pubmed publisher
    ..library and an in vitro antimalarial assay identified active fractions derived from the Australian marine sponge Plakortis lita . Bioassay-guided fractionation of the CH2Cl2/CH3OH extract from P...
  4. Yu H, Liu X, Xu Y, Gan J, Jiao W, Shen Y, et al. Woodylides A-C, new cytotoxic linear polyketides from the South China Sea sponge Plakortis simplex. Mar Drugs. 2012;10:1027-36 pubmed publisher
    Three new polyketides, woodylides A-C (1-3), were isolated from the ethanol extract of the South China Sea sponge Plakortis simplex. The structures were elucidated by spectroscopic data (IR, 1D and 2D NMR, and HRESIMS)...
  5. Della Sala G, Hochmuth T, Costantino V, Teta R, GERWICK W, Gerwick L, et al. Polyketide genes in the marine sponge Plakortis simplex: a new group of mono-modular type I polyketide synthases from sponge symbionts. Environ Microbiol Rep. 2013;5:809-18 pubmed publisher
    ..Screening of the metagenome of the marine sponge Plakortis simplex led to the discovery of the swf family, a new group of mono-modular type I polyketide synthase/fatty ..
  6. Barber J, Quek N, Leahy D, Miller J, Bellows D, Northcote P. Lehualides E-K, cytotoxic metabolites from the Tongan marine sponge Plakortis sp. J Nat Prod. 2011;74:809-15 pubmed publisher
    Spectroscopy-guided chemical analysis of a marine sponge from the genus Plakortis, collected in Tonga, yielded seven new metabolites of polyketide origin, lehualides E-K (5-11), four of which incorporate various sulfur functionalities...
  7. Fattorusso C, Persico M, Calcinai B, Cerrano C, Parapini S, Taramelli D, et al. Manadoperoxides A-D from the Indonesian sponge Plakortis cfr. simplex. Further insights on the structure-activity relationships of simple 1,2-dioxane antimalarials. J Nat Prod. 2010;73:1138-45 pubmed publisher
    The new endoperoxyketal polyketides manadoperoxides A-D (2-5) have been isolated from the Indonesian sponge Plakortis cfr. simplex and their stereostructures established by means of spectroscopic data and semisynthetic transformations...
  8. Sata N, Abinsay H, Yoshida W, Horgen F, Sitachitta N, Kelly M, et al. Lehualides A-D, metabolites from a Hawaiian sponge of the genus Plakortis. J Nat Prod. 2005;68:1400-3 pubmed
    A collection of an undescribed marine sponge of the genus Plakortis yielded four new "polyketide-derived" metabolites, lehualides A-D (1-4). The structures of compounds 1-4 were elucidated by interpretation of spectral data...
  9. Kossuga M, Nascimento A, Reimão J, Tempone A, Taniwaki N, Veloso K, et al. Antiparasitic, antineuroinflammatory, and cytotoxic polyketides from the marine sponge Plakortis angulospiculatus collected in Brazil. J Nat Prod. 2008;71:334-9 pubmed publisher
    Investigation of the bioactive crude extract from the sponge Plakortis angulospiculatus from Brazil led to the isolation of plakortenone ( 1) as a new polyketide, along with five known polyketides ( 2- 6) previously isolated from other ..

More Information

Publications44

  1. Chianese G, Fattorusso E, Scala F, Teta R, Calcinai B, Bavestrello G, et al. Manadoperoxides, a new class of potent antitrypanosomal agents of marine origin. Org Biomol Chem. 2012;10:7197-207 pubmed publisher
    Chemical investigation of the marine sponge Plakortis cfr. lita afforded a library of endoperoxyketal polyketides, manadoperoxides B-K (3-5 and 7-13) and peroxyplakoric esters B(3) (6) and C (14)...
  2. Liu X, Song Y, Zhang H, Yang F, Yu H, Jiao W, et al. Simplextones A and B, unusual polyketides from the marine sponge Plakortis simplex. Org Lett. 2011;13:3154-7 pubmed publisher
    Two novel polyketides, simplextones A (1) and B (2), were isolated from the sponge Plakortis simplex. Their structures were established by spectroscopic methods...
  3. Ralifo P, Sanchez L, Gassner N, Tenney K, Lokey R, Holman T, et al. Pyrroloacridine alkaloids from Plakortis quasiamphiaster: structures and bioactivity. J Nat Prod. 2007;70:95-9 pubmed
    A re-collection of Plakortis quasiamphiaster from Vanuatu in 2003 resulted in the isolation of three known compounds, plakinidine A (1) and amphiasterins B1 (6) and B2 (7)...
  4. Feng Y, Davis R, Sykes M, Avery V, Camp D, Quinn R. Antitrypanosomal cyclic polyketide peroxides from the Australian marine sponge Plakortis sp. J Nat Prod. 2010;73:716-9 pubmed publisher
    Bioassay-guided fractionation of the crude extract from the Australian marine sponge Plakortis sp...
  5. Schirmeister T, Oli S, Wu H, Della Sala G, Costantino V, Seo E, et al. Cytotoxicity of Endoperoxides from the Caribbean Sponge Plakortis halichondrioides towards Sensitive and Multidrug-Resistant Leukemia Cells: Acids vs. Esters Activity Evaluation. Mar Drugs. 2017;15: pubmed publisher
    ..b>3), and dihydroplakortin (4) have been isolated from a sample of the Caribbean sponge Plakortis halichondrioides...
  6. Domingos C, Moraes F, Muricy G. Four new species of Plakinidae (Porifera: Homoscleromorpha) from Brazil. Zootaxa. 2013;3718:530-44 pubmed
    ..trilopha), Plakinastrella (P. microspiculfera, P. onkodes), and Plakortis (P. angulospiculatus, P. halichondrioides, P. insularis, and P microrhabdifera)...
  7. Li J, Li C, Riccio R, Lauro G, Bifulco G, Li T, et al. Chemistry and Selective Tumor Cell Growth Inhibitory Activity of Polyketides from the South China Sea Sponge Plakortis sp. Mar Drugs. 2017;15: pubmed publisher
    ..origin, was isolated with eight known analogues (2-9) from the South China Sea sponge Plakortis sp...
  8. Feng G, Sun W, Zhang F, Orlic S, Li Z. Functional Transcripts Indicate Phylogenetically Diverse Active Ammonia-Scavenging Microbiota in Sympatric Sponges. Mar Biotechnol (NY). 2018;20:131-143 pubmed publisher
    ..were analyzed to reveal the active ammonia-scavenging microbiota in the sympatric sponges Theonella swinhoei, Plakortis simplex, and Phakellia fusca, and seawater...
  9. Skorokhod O, Davalos Schafler D, Gallo V, Valente E, Ulliers D, Notarpietro A, et al. Oxidative stress-mediated antimalarial activity of plakortin, a natural endoperoxide from the tropical sponge Plakortis simplex. Free Radic Biol Med. 2015;89:624-37 pubmed publisher
    Plakortin, a polyketide endoperoxide from the sponge Plakortis simplex has antiparasitic activity against P. falciparum. Similar to artemisinin, its activity depends on the peroxide functionality...
  10. Vicente J, Zea S, Hill R. Sponge epizoism in the Caribbean and the discovery of new Plakortis and <br />Haliclona species, and polymorphism of Xestospongia deweerdtae (Porifera). Zootaxa. 2016;4178:209-233 pubmed publisher
    The new discovery by Vicente et al. (2014) of specialized epizoic symbioses between sponges of the genera Plakortis and Xestospongia revealed the obligate interaction of two new Plakortis spp...
  11. Jamison M, Dalisay D, Molinski T. Peroxide Natural Products from Plakortis zyggompha and the Sponge Association Plakortis halichondrioides-Xestospongia deweerdtae: Antifungal Activity against Cryptococcus gattii. J Nat Prod. 2016;79:555-63 pubmed publisher
    ..Investigation of antifungal extracts of the marine sponge association Plakortis halichondrioides-Xestospongia deweerdtae and the sponge Plakortis zyggompha from the Bahamas led to the ..
  12. Costantino V, Della Sala G, Saurav K, Teta R, Bar Shalom R, Mangoni A, et al. Plakofuranolactone as a Quorum Quenching Agent from the Indonesian Sponge Plakortis cf. lita. Mar Drugs. 2017;15: pubmed publisher
    ..the LasI/R QS system, plakofuranolactone (1), was discovered in the extract of the marine sponge Plakortis cf...
  13. Jiménez Romero C, Rode J, Pérez Y, Franzblau S, Rodriguez A. Exploring the Sponge Consortium Plakortis symbiotica-Xestospongia deweerdtae as a Potential Source of Antimicrobial Compounds and Probing the Pharmacophore for Antituberculosis Activity of Smenothiazole A by Diverted Total Synthesis. J Nat Prod. 2017;80:2295-2303 pubmed publisher
    ..of the bioactive CHCl3-MeOH (1:1) extracts obtained from two collections of the sponge consortium Plakortis symbiotica-Xestospongia deweerdtae from Puerto Rico provided two new plakinidone analogues, designated as ..
  14. Chianese G, Scala F, Calcinai B, Cerrano C, Dien H, Kaiser M, et al. Natural and semisynthetic analogues of manadoperoxide B reveal new structural requirements for trypanocidal activity. Mar Drugs. 2013;11:3297-308 pubmed publisher
    Chemical analysis of the Indonesian sponge Plakortis cfr. lita afforded two new analogues of the potent trypanocidal agent manadoperoxide B (1), namely 12-isomanadoperoxide B (2) and manadoperoxidic acid B (3)...
  15. Oh J, Hwang B, Kang O, Kwon D, Rho J. New constituents from the Korean sponge Plakortis simplex. Mar Drugs. 2013;11:4407-18 pubmed publisher
    Six new cyclic peroxides (1-6) were isolated from the Korean sponge Plakortis simplex, along with two new alkylpyridinium alkaloids (7 and 8)...
  16. Tanaka N, Asai M, Takahashi Nakaguchi A, Gonoi T, Fromont J, Kobayashi J. Manzamenone O, new trimeric fatty acid derivative from a marine sponge Plakortis sp. Org Lett. 2013;15:2518-21 pubmed publisher
    A new structurally unique trimeric fatty acid derivative, manzamenone O (1), was isolated from a marine sponge Plakortis sp. Manzamenone O (1) has a novel skeleton consisting of C-C bonded octahydroindenone and dioxabicyclo[3.3...
  17. Kubota T, Ishiguro Y, Takahashi Nakaguchi A, Fromont J, Gonoi T, Kobayashi J. Manzamenones L-N, new dimeric fatty-acid derivatives from an Okinawan marine sponge Plakortis sp. Bioorg Med Chem Lett. 2013;23:244-7 pubmed publisher
    Three new polyketides, manzamenones L-N (1-3), have been isolated from an Okinawan marine sponge of the genus Plakortis. The structures of 1-3 were elucidated on the basis of spectroscopic data...
  18. Yong K, Barnych B, De Voss J, Vatèle J, Garson M. Plakortolide stereochemistry revisited: the checkered history of plakortolides e and I. J Nat Prod. 2012;75:1792-7 pubmed publisher
    The relative configuration of the plakortolide metabolite (4) isolated from a Madagascan Plakortis sp...
  19. Bourcet E, Kaufmann L, Arzt S, Bihlmeier A, Klopper W, Schepers U, et al. The plakotenins: biomimetic Diels-Alder reactions, total synthesis, structural investigations, and chemical biology. Chemistry. 2012;18:15004-20 pubmed publisher
    ..The syntheses prove the relative and absolute stereochemistry of the latter. The chemical biology of the plakotenins was investigated on selected compounds...
  20. Holla H, Labaied M, Pham N, Jenkins I, Stuart K, Quinn R. Synthesis of antitrypanosomal 1,2-dioxane derivatives based on a natural product scaffold. Bioorg Med Chem Lett. 2011;21:4793-7 pubmed publisher
    ..natural product based scaffold (6), based on antitrypanosomal and antimalarial compounds isolated from different Plakortis species is described...
  21. Arzt S, Bourcet E, Muller T, Bräse S. Enantioselective total synthesis of plakotenin, a cytotoxic metabolite from Plakortis sp. Org Biomol Chem. 2010;8:3300-6 pubmed publisher
    ..This marine natural product was isolated from an Okinawan sponge of the genus Plakortis and shows potent biological activity against several cancerous cell lines...
  22. Marty M, Vicente J, Oyler B, PLACE A, Hill R. Sponge symbioses between Xestospongia deweerdtae and Plakortis spp. are not motivated by shared chemical defense against predators. PLoS ONE. 2017;12:e0174816 pubmed publisher
    The recently described epizoic sponge-sponge symbioses between Xestospongia deweerdtae and two species of Plakortis present an unusual series of sponge interactions...
  23. Berrue F, Thomas O, Fernandez R, Amade P. Iso-, nor-, and dinor-spiculoic acids A, polyketides from the marine sponge Plakortis zyggompha. J Nat Prod. 2005;68:547-9 pubmed
    ..acids A (1, 2, and 3, respectively) with a rare spiculane skeleton were isolated from the marine sponge Plakortis zyggompha, collected in the waters south of Martinique...
  24. Zhang J, Tang X, Li J, Li P, de Voogd N, Ni X, et al. Cytotoxic polyketide derivatives from the South China Sea sponge Plakortis simplex. J Nat Prod. 2013;76:600-6 pubmed publisher
    ..4), and plakorsin D (5), together with six known analogues (6-11) were isolated from the South China Sea sponge Plakortis simplex. Their structures were identified by spectroscopic and chemical methods, including NMR, MS, and IR...
  25. Kaur I, Das A, Acharya M, Klenk H, Sree A, Mayilraj S. Planococcus plakortidis sp. nov., isolated from the marine sponge Plakortis simplex (Schulze). Int J Syst Evol Microbiol. 2012;62:883-9 pubmed publisher
    A novel coccoid-shaped strain, AS/ASP6 (II)T, was isolated from a sample taken from Plakortis simplex (Schulze), a marine sponge, collected at a depth of 30 m from the Bay of Bengal...
  26. Taglialatela Scafati O, Fattorusso E, Romano A, Scala F, Barone V, Cimino P, et al. Insight into the mechanism of action of plakortins, simple 1,2-dioxane antimalarials. Org Biomol Chem. 2010;8:846-56 pubmed publisher
    ..of the antimalarial action of plakortin and dihydroplakortin, simple 1,2-dioxanes isolated from the sponge Plakortis simplex...
  27. Salim H, Piva O. A short access to 3-hydroxy-4-hydroxymethyltetrahydrofurans: application to the total synthesis of amphiasterin B4. J Org Chem. 2009;74:2257-60 pubmed publisher
    The first total synthesis of amphiasterin B4, a secondary metabolite previously isolated from Plakortis quasiamphiaster has been achieved...
  28. Fattorusso E, Romano A, Scala F, Taglialatela Scafati O. Simplexidine, a 4-alkylpyridinium alkaloid from the Caribbean sponge Plakortis simplex. Molecules. 2008;13:1465-71 pubmed
    Chemical analysis of the secondary metabolites of the Caribbean sponge Plakortis simplex, a source of many bioactive compounds, showed the presence of the new metabolite simplexidine (4), belonging to the extremely rare class of 4-alkyl-..
  29. Wang X, Lavrov D. Seventeen new complete mtDNA sequences reveal extensive mitochondrial genome evolution within the Demospongiae. PLoS ONE. 2008;3:e2723 pubmed publisher
    ..order Homosclerophorida) including gene rearrangements, loss of tRNA genes, and the presence of two introns in Plakortis angulospiculatus...
  30. Kirkham J, Lee V, Baldwin J. Stereochemical reassignment of Mehta and Kundu's spiculoic acid a analogue. Org Lett. 2006;8:5537-40 pubmed
    ..A revised structure is proposed for Mehta and Kundu's analogue after a careful analysis of their key synthetic transformations and published data. [reaction: see text]...
  31. Costantino V, Fattorusso E, Menna M, Taglialatela Scafati O. Chemical diversity of bioactive marine natural products: an illustrative case study. Curr Med Chem. 2004;11:1671-92 pubmed
    ..variety of the structures present in marine organisms has been illustrated through the case study of the sponge Plakortis simplex, whose chemical analysis, started in our laboratories about ten years ago, revealed an incredible ..
  32. Di Brisco R, Ronchetti F, Mangoni A, Costantino V, Compostella F. Development of a fluorescent probe for the study of the sponge-derived simplexide immunological properties. Carbohydr Res. 2012;348:27-32 pubmed publisher
  33. Ko J, Hwang H, Chin J, Hahn D, Lee J, Yang I, et al. A stereo-controlled synthesis of 2,4-dimethyl-4-hydroxy-16-phenylhexadecanoic acid 1,4-lactone and its PPAR activities. Bioorg Med Chem Lett. 2010;20:6017-9 pubmed publisher
    ..In the PPAR agonistic assay, the most potent of the four stereoisomers had EC(50) values of 12 ?M for mPPAR?, 9 ?M for mPPAR? and >100 ?M for mPPAR?...
  34. Dalisay D, Quach T, Nicholas G, Molinski T. Amplification of the Cotton effect of a single chromophore through liposomal ordering-stereochemical assignment of plakinic acids I and J. Angew Chem Int Ed Engl. 2009;48:4367-71 pubmed publisher
    ..This effect was exploited to assign the configuration of new polyketide peroxides such as 1 from the sponge Plakortis halichondroides.
  35. Borchert M, Nielsen P, Graeber I, Kaesler I, Szewzyk U, Pape T, et al. Bacillus plakortidis sp. nov. and Bacillus murimartini sp. nov., novel alkalitolerant members of rRNA group 6. Int J Syst Evol Microbiol. 2007;57:2888-93 pubmed
    ..Strain P203(T) was isolated from material from the sponge Plakortis simplex that was obtained from the Sula-Ridge, Norwegian Sea...