aplysia

Summary

Summary: An opisthobranch mollusk of the order Anaspidea. It is used frequently in studies of nervous system development because of its large identifiable neurons. Aplysiatoxin and its derivatives are not biosynthesized by Aplysia, but acquired by ingestion of Lyngbya (seaweed) species.

Top Publications

  1. Ross G, Dyer J, Castellucci V, Sossin W. Mnk is a negative regulator of cap-dependent translation in Aplysia neurons. J Neurochem. 2006;97:79-91 pubmed
    To investigate the mechanisms underlying regulation of eukaryotic initiation factor 4E (eIF4E) phosphorylation in Aplysia neurons, we have cloned the Aplysia homolog of the vertebrate eIF4E kinases, Mnk1 and -2...
  2. Martínez Rubio C, Serrano G, Miller M. Localization of biogenic amines in the foregut of Aplysia californica: catecholaminergic and serotonergic innervation. J Comp Neurol. 2009;514:329-42 pubmed publisher
    This study examined the catecholaminergic and serotonergic innervation of the foregut of Aplysia californica, a model system in which the control of feeding behaviors can be investigated at the cellular level...
  3. Ye H, Morton D, Chiel H. Neuromechanics of coordination during swallowing in Aplysia californica. J Neurosci. 2006;26:1470-85 pubmed
    ..the roles of two identified motor neurons, B7 and B8, which contribute to feeding behavior in the marine mollusk Aplysia californica...
  4. Miller N, Katzoff A, Susswein A. Nitric oxide induces aspects of egg-laying behavior in Aplysia. J Exp Biol. 2008;211:2388-96 pubmed publisher
    b>Aplysia egg laying is a complex behavior requiring synchronized activity in many organs. Aspects of the behavior are synchronized via the direct effects of peptide bag cell neurohormones and via stimuli arising during the behavior...
  5. Choi S, Lee Y, Rim Y, Kim T, Moroz L, Kandel E, et al. Differential evolutionary rates of neuronal transcriptome in Aplysia kurodai and Aplysia californica as a tool for gene mining. J Neurogenet. 2010;24:75-82 pubmed publisher
    The marine mollusk Aplysia is a fascinating model organism for studying molecular mechanisms underlying learning and memory. However, evolutionary studies about Aplysia have been limited by the lack of its genomic information...
  6. Jing J, Sweedler J, Cropper E, Alexeeva V, Park J, Romanova E, et al. Feedforward compensation mediated by the central and peripheral actions of a single neuropeptide discovered using representational difference analysis. J Neurosci. 2010;30:16545-58 pubmed publisher
    ..We provide evidence that an Aplysia neuropeptide, identified using an enhanced representational difference analysis procedure, implements feedforward ..
  7. Liu J, Hu J, Wu F, Schwartz J, Schacher S. Two mRNA-binding proteins regulate the distribution of syntaxin mRNA in Aplysia sensory neurons. J Neurosci. 2006;26:5204-14 pubmed publisher
    Targeting mRNAs to different functional domains within neurons is crucial to memory storage. In Aplysia sensory neurons, syntaxin mRNA accumulates at the axon hillock during long-term facilitation of sensory-motor neuron synapses ..
  8. Ha T, Kohn A, Bobkova Y, Moroz L. Molecular characterization of NMDA-like receptors in Aplysia and Lymnaea: relevance to memory mechanisms. Biol Bull. 2006;210:255-70 pubmed
    ..Here, we cloned two NMDA-type receptors from the sea slug Aplysia californica, AcNR1-1 and AcNR1-2, as well as their homologs from the freshwater pulmonate snail Lymnaea stagnalis,..
  9. Decourt B, Munnamalai V, Lee A, Sanchez L, Suter D. Cortactin colocalizes with filopodial actin and accumulates at IgCAM adhesion sites in Aplysia growth cones. J Neurosci Res. 2009;87:1057-68 pubmed publisher
    ..Previous studies have shown that local clustering and immobilization of apCAM, the Aplysia homolog of NCAM, induces Src kinase activity and F-actin polymerization in the peripheral domain of cultured ..

More Information

Publications102 found, 100 shown here

  1. Burnette D, Ji L, Schaefer A, Medeiros N, Danuser G, Forscher P. Myosin II activity facilitates microtubule bundling in the neuronal growth cone neck. Dev Cell. 2008;15:163-9 pubmed publisher
    ..Upon Myosin II inhibition, the movement of actin filaments and MTs immediately stopped and MTs unbundled. Thus, Myosin II-dependent compressive force is necessary for normal MT bundling in the growth cone neck. ..
  2. Brams M, Gay E, Sáez J, Guskov A, van Elk R, van der Schors R, et al. Crystal structures of a cysteine-modified mutant in loop D of acetylcholine-binding protein. J Biol Chem. 2011;286:4420-8 pubmed publisher
  3. Jakubowski J, Hatcher N, Xie F, Sweedler J. The first gamma-carboxyglutamate-containing neuropeptide. Neurochem Int. 2006;49:223-9 pubmed publisher
    ..A rare carboxylation modification is described on the D-peptide from the insulin prohormone in the sea slug, Aplysia californica...
  4. Lee J, Lee S, Lee C, Chang D, Lee Y, Kim H, et al. PKA-activated ApAF-ApC/EBP heterodimer is a key downstream effector of ApCREB and is necessary and sufficient for the consolidation of long-term facilitation. J Cell Biol. 2006;174:827-38 pubmed
    ..b>Aplysia activating factor (ApAF) is known to be a positive transcription factor that forms heterodimers with ApC/EBP and ..
  5. Villareal G, Li Q, Cai D, Fink A, Lim T, Bougie J, et al. Role of protein kinase C in the induction and maintenance of serotonin-dependent enhancement of the glutamate response in isolated siphon motor neurons of Aplysia californica. J Neurosci. 2009;29:5100-7 pubmed publisher
    Serotonin (5-HT) mediates learning-related facilitation of sensorimotor synapses in Aplysia californica. Under some circumstances 5-HT-dependent facilitation requires the activity of protein kinase C (PKC)...
  6. Jin I, Udo H, Hawkins R. Rapid increase in clusters of synaptophysin at onset of homosynaptic potentiation in Aplysia. Proc Natl Acad Sci U S A. 2011;108:11656-61 pubmed publisher
    ..For example, recruitment of presynaptic proteins during long-term facilitation by 5HT in Aplysia is delayed for several hours, suggesting that whereas activity-dependent forms of plasticity, such as long-term ..
  7. Schaefer A, Schoonderwoert V, Ji L, Mederios N, Danuser G, Forscher P. Coordination of actin filament and microtubule dynamics during neurite outgrowth. Dev Cell. 2008;15:146-62 pubmed publisher
    ..These results reveal a role for Rho Kinase and myosin II contractility in regulation of microtubule behavior during neuronal growth. ..
  8. Fioravante D, Liu R, Netek A, Cleary L, Byrne J. Synapsin regulates Basal synaptic strength, synaptic depression, and serotonin-induced facilitation of sensorimotor synapses in Aplysia. J Neurophysiol. 2007;98:3568-80 pubmed
    ..We previously reported that the neuromodulator serotonin (5-HT) led to the phosphorylation and redistribution of Aplysia synapsin, suggesting that synapsin may be a good candidate for the regulation of vesicle mobilization underlying ..
  9. Kawasaki S, Watanabe S, Kimura S, Fujita R, Ochiai J, Sasaki K. Regulation of dopamine-induced Na+ current response by small G-protein RhoB or C and phospholipase D in Aplysia neurons. Neurosci Res. 2008;60:147-55 pubmed publisher
    ..stimulation of D1-like receptor by dopamine (DA) induces a slow Na+ current response in the identified neurons of Aplysia under voltage-clamp...
  10. Cummins S, Erpenbeck D, Zou Z, Claudianos C, Moroz L, Nagle G, et al. Candidate chemoreceptor subfamilies differentially expressed in the chemosensory organs of the mollusc Aplysia. BMC Biol. 2009;7:28 pubmed publisher
    ..In the mollusc Aplysia californica, mate-attraction is mediated by a blend of water-borne protein pheromones that are detected by ..
  11. Carroll M, Dyer J, Sossin W. Serotonin increases phosphorylation of synaptic 4EBP through TOR, but eukaryotic initiation factor 4E levels do not limit somatic cap-dependent translation in aplysia neurons. Mol Cell Biol. 2006;26:8586-98 pubmed
    The target of rapamycin (TOR) plays an important role in memory formation in Aplysia californica. Here, we characterize one of the downstream targets of TOR, the eukaryotic initiation factor 4E (eIF4E) binding protein (4EBP) from Aplysia...
  12. Pérez E, Cassels B, Zapata Torres G. Molecular modeling of the alpha9alpha10 nicotinic acetylcholine receptor subtype. Bioorg Med Chem Lett. 2009;19:251-4 pubmed publisher
    ..complexed with acetylcholine, nicotine and alpha-conotoxin RgIA, using as templates the crystal structures of Aplysia californica and Lymnaea stagnalis acetylcholine binding proteins...
  13. Xiong Y, Lee A, Suter D, Lee G. Topography and nanomechanics of live neuronal growth cones analyzed by atomic force microscopy. Biophys J. 2009;96:5060-72 pubmed publisher
    ..In this study, we used the AFM to study the P domain, T zone, and C domain of live Aplysia growth cones...
  14. Lyons L, Collado M, Khabour O, Green C, Eskin A. The circadian clock modulates core steps in long-term memory formation in Aplysia. J Neurosci. 2006;26:8662-71 pubmed
    The circadian clock modulates the induction of long-term sensitization (LTS) in Aplysia such that long-term memory formation is significantly suppressed when animals are trained at night...
  15. Collado M, Lyons L, Levenson J, Khabour O, Pita Almenar J, Schrader L, et al. In vivo regulation of an Aplysia glutamate transporter, ApGT1, during long-term memory formation. J Neurochem. 2007;100:1315-28 pubmed
    ..mechanisms responsible for the increase in glutamate uptake associated with increased glutamate release at the Aplysia sensorimotor synapse during long-term sensitization (LTS) and long-term facilitation...
  16. Barco A, Bailey C, Kandel E. Common molecular mechanisms in explicit and implicit memory. J Neurochem. 2006;97:1520-33 pubmed
    ..review, we focus on recent advances in our understanding of two types of memory storage: (i) sensitization in Aplysia, a simple form of implicit memory, and (ii) formation of explicit spatial memories in the mouse hippocampus...
  17. Philips G, Sherff C, Menges S, Carew T. The tail-elicited tail withdrawal reflex of Aplysia is mediated centrally at tail sensory-motor synapses and exhibits sensitization across multiple temporal domains. Learn Mem. 2011;18:272-82 pubmed publisher
    The defensive withdrawal reflexes of Aplysia californica have provided powerful behavioral systems for studying the cellular and molecular basis of memory formation...
  18. Carlson S, Fieber L. Physiological evidence that D-aspartate activates a current distinct from ionotropic glutamate receptor currents in Aplysia californica neurons. J Neurophysiol. 2011;106:1629-36 pubmed publisher
    D-Aspartate (D-Asp) activates an excitatory current in neurons of Aplysia californica. Although D-Asp is presumed to activate a subset of L-glutamate (L-Glu) channels, the identities of putative d-Asp receptors and channels are unclear...
  19. Moroz L, Edwards J, Puthanveettil S, Kohn A, Ha T, Heyland A, et al. Neuronal transcriptome of Aplysia: neuronal compartments and circuitry. Cell. 2006;127:1453-67 pubmed
    Molecular analyses of Aplysia, a well-established model organism for cellular and systems neural science, have been seriously handicapped by a lack of adequate genomic information...
  20. Cummins S, Degnan B, Nagle G. Characterization of Aplysia Alb-1, a candidate water-borne protein pheromone released during egg laying. Peptides. 2008;29:152-61 pubmed publisher
    Pheromones are known to be important to the innate behavior of marine animals. Attraction in Aplysia involves the long-distance water-borne protein pheromones attractin, enticin, temptin and seductin, which are released from the albumen ..
  21. Kasheverov I, Zhmak M, Fish A, Rucktooa P, Khruschov A, Osipov A, et al. Interaction of alpha-conotoxin ImII and its analogs with nicotinic receptors and acetylcholine-binding proteins: additional binding sites on Torpedo receptor. J Neurochem. 2009;111:934-44 pubmed publisher
    ..alpha7 nAChRs in the cell line GH(4)C(1) (IC(50) 17 and 23 microM, respectively) and from Lymnaea stagnalis and Aplysia californica AChBPs (IC(50) 2.0-9.0 microM)...
  22. Cummins S, Leblanc L, Degnan B, Nagle G. Molecular identification of candidate chemoreceptor genes and signal transduction components in the sensory epithelium of Aplysia. J Exp Biol. 2009;212:2037-44 pubmed publisher
    ..In this study, we cloned two genes from the marine mollusk Aplysia dactylomela which encode multi-transmembrane proteins...
  23. Kehoe J, Buldakova S, Acher F, Dent J, Bregestovski P, Bradley J. Aplysia cys-loop glutamate-gated chloride channels reveal convergent evolution of ligand specificity. J Mol Evol. 2009;69:125-41 pubmed publisher
    ..We have now cloned and expressed two 2-cys-loop receptors from Aplysia californica, a lophotrocozoan, and have shown that they form homomeric glutamate receptors...
  24. Farah C, Weatherill D, Dunn T, Sossin W. PKC differentially translocates during spaced and massed training in Aplysia. J Neurosci. 2009;29:10281-6 pubmed publisher
    Learning is highly regulated by the pattern of training. In Aplysia, an important organism for the development of cellular and molecular models of learning, spaced versus massed application of the same stimulus leads to different forms ..
  25. Antzoulatos E, Byrne J. Long-term sensitization training produces spike narrowing in Aplysia sensory neurons. J Neurosci. 2007;27:676-83 pubmed
    Both short- and long-term sensitization of withdrawal reflexes of Aplysia are attributable at least in part to facilitation of the sensorimotor synapse...
  26. Moreau C, Ashamu G, Bailey V, Galione A, Guse A, Potter B. Synthesis of cyclic adenosine 5'-diphosphate ribose analogues: a C2'endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor. Org Biomol Chem. 2011;9:278-90 pubmed publisher
  27. Liu Q, Graeff R, Kriksunov I, Jiang H, Zhang B, Oppenheimer N, et al. Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase. J Biol Chem. 2009;284:27637-45 pubmed publisher
    ..and degradation of cADPR are catalyzed by a family of related enzymes, including the ADP-ribosyl cyclase from Aplysia california (ADPRAC) and CD38 from human...
  28. Antonov I, Kandel E, Hawkins R. Presynaptic and postsynaptic mechanisms of synaptic plasticity and metaplasticity during intermediate-term memory formation in Aplysia. J Neurosci. 2010;30:5781-91 pubmed publisher
    ..short-term and intermediate-term behavioral sensitization and dishabituation in a semi-intact preparation of the Aplysia siphon-withdrawal reflex...
  29. Heyland A, Vue Z, Voolstra C, Medina M, Moroz L. Developmental transcriptome of Aplysia californica. J Exp Zool B Mol Dev Evol. 2011;316B:113-34 pubmed publisher
    ..Here, we characterize transcriptomes of embryonic, larval, and metamorphic development in the marine mollusc Aplysia californica and reveal novel molecular components associated with life history transitions...
  30. Zimmerman T, Rubakhin S, Sweedler J. MALDI mass spectrometry imaging of neuronal cell cultures. J Am Soc Mass Spectrom. 2011;22:828-36 pubmed publisher
    ..Cultures of Aplysia californica neurons are grown on an array of glass beads embedded in a stretchable layer of Parafilm M...
  31. Bougie J, Cai D, Hastings M, Farah C, Chen S, Fan X, et al. Serotonin-induced cleavage of the atypical protein kinase C Apl III in Aplysia. J Neurosci. 2012;32:14630-40 pubmed publisher
    ..of a transcript initiating in an intron of the protein kinase C? (PKC?) gene, this transcript does not exist in Aplysia californica despite the fact that inhibitors of PKM? erase memory in Aplysia in a fashion similar to rodents...
  32. Lyles V, Zhao Y, Martin K. Synapse formation and mRNA localization in cultured Aplysia neurons. Neuron. 2006;49:349-56 pubmed
    ..In isolated Aplysia sensory neurons, which do not form chemical synapses, sensorin mRNA is diffusely distributed throughout distal ..
  33. Reissner K, Shobe J, Carew T. Molecular nodes in memory processing: insights from Aplysia. Cell Mol Life Sci. 2006;63:963-74 pubmed
    ..e. have different 'weights') depending upon the nature and pattern of the activating stimulus. The marine mollusk Aplysia has proven useful for a molecular analysis of memory formation...
  34. Proekt A, Jing J, Weiss K. Multiple contributions of an input-representing neuron to the dynamics of the aplysia feeding network. J Neurophysiol. 2007;97:3046-56 pubmed
    In Aplysia, mutually antagonistic ingestive and egestive behaviors are produced by the same multifunctional central pattern generator (CPG) circuit...
  35. Hatcher N, Sweedler J. Aplysia bag cells function as a distributed neurosecretory network. J Neurophysiol. 2008;99:333-43 pubmed
    ..we probe the well-characterized hormonal model, the reproductive bag cell neuroendocrine system of the sea slug Aplysia californica...
  36. Lee Y, Choi S, Lee S, Kim H, Park H, Lee N, et al. Identification of a serotonin receptor coupled to adenylyl cyclase involved in learning-related heterosynaptic facilitation in Aplysia. Proc Natl Acad Sci U S A. 2009;106:14634-9 pubmed publisher
    Serotonin (5-HT) plays a critical role in modulating synaptic plasticity in the marine mollusc Aplysia and in the mammalian nervous system...
  37. Cummins S, Nuurai P, Nagle G, Degnan B. Conservation of the egg-laying hormone neuropeptide and attractin pheromone in the spotted sea hare, Aplysia dactylomela. Peptides. 2010;31:394-401 pubmed publisher
    In the marine opisthobranch mollusc, Aplysia, secreted peptides and proteins play an essential role in egg laying and mate attraction...
  38. Fieber L, Carlson S, Capo T, Schmale M. Changes in D-aspartate ion currents in the Aplysia nervous system with aging. Brain Res. 2010;1343:28-36 pubmed publisher
    ..D-Asp electrophysiological responses were studied as a potential correlate of aging in the California sea hare, Aplysia californica...
  39. Brams M, Pandya A, Kuzmin D, van Elk R, Krijnen L, Yakel J, et al. A structural and mutagenic blueprint for molecular recognition of strychnine and d-tubocurarine by different cys-loop receptors. PLoS Biol. 2011;9:e1001034 pubmed publisher
  40. Jin I, Puthanveettil S, Udo H, Karl K, Kandel E, Hawkins R. Spontaneous transmitter release is critical for the induction of long-term and intermediate-term facilitation in Aplysia. Proc Natl Acad Sci U S A. 2012;109:9131-6 pubmed publisher
    ..is critical for the induction of a learning-related form of synaptic plasticity, long-term facilitation in Aplysia. In addition, we have found that this signaling is engaged quite early, during an intermediate-term stage that is ..
  41. Abrams T. Studies on Aplysia neurons suggest treatments for chronic human disorders. Curr Biol. 2012;22:R705-11 pubmed publisher
    For decades, the marine snail Aplysia has proven to be a powerful system for analyzing basic neurobiological mechanisms, particularly cellular and molecular mechanisms of neural plasticity...
  42. Kachoei B, Knox R, Uthuza D, Levy S, Kaczmarek L, Magoski N. A store-operated Ca(2+) influx pathway in the bag cell neurons of Aplysia. J Neurophysiol. 2006;96:2688-98 pubmed
    ..In the bag cell neurons of Aplysia californica, prior work has suggested that a Ca(2+) entry pathway can be activated by Ca(2+) store depletion...
  43. Koh H, Weiss K. Activity-dependent peptidergic modulation of the plateau-generating neuron B64 in the feeding network of Aplysia. J Neurophysiol. 2007;97:1862-7 pubmed
    ..of such plasticity is the progressive shortening of the duration of protraction phase of feeding responses of Aplysia that occurs when feeding responses are repeatedly elicited...
  44. Lee S, Lim C, Park H, Lee J, Han J, Kim H, et al. Nuclear translocation of CAM-associated protein activates transcription for long-term facilitation in Aplysia. Cell. 2007;129:801-12 pubmed
    ..long-term facilitation (LTF) of the synapses between sensory and motor neurons of the gill-withdrawal reflex in Aplysia. To explore how apCAM downregulation at the plasma membrane and CREB-mediated transcription in the nucleus, both ..
  45. Nargeot R, Petrissans C, Simmers J. Behavioral and in vitro correlates of compulsive-like food seeking induced by operant conditioning in Aplysia. J Neurosci. 2007;27:8059-70 pubmed
    ..Here, we explored such behavioral plasticity in Aplysia by analyzing how appetitive reward stimulation in a form of operant conditioning can modify a goal-directed ..
  46. Zhang L, Tello J, Zhang W, Tsai P. Molecular cloning, expression pattern, and immunocytochemical localization of a gonadotropin-releasing hormone-like molecule in the gastropod mollusk, Aplysia californica. Gen Comp Endocrinol. 2008;156:201-9 pubmed publisher
    ..the full-length cDNA of a GnRH-like molecule from the central nervous system of a gastropod mollusk, the sea hare Aplysia californica. The open reading frame of this cDNA encodes a protein of 147 amino acids...
  47. Yamada K, Ojika M, Kigoshi H, Suenaga K. Aplyronine A, a potent antitumour macrolide of marine origin, and the congeners aplyronines B-H: chemistry and biology. Nat Prod Rep. 2009;26:27-43 pubmed
    Aplyronines A-H are cytotoxic macrolides isolated from the sea hare Aplysia kurodai...
  48. Zhang X, Forscher P. Rac1 modulates stimulus-evoked Ca(2+) release in neuronal growth cones via parallel effects on microtubule/endoplasmic reticulum dynamics and reactive oxygen species production. Mol Biol Cell. 2009;20:3700-12 pubmed publisher
    ..These results cast Rac1 as a key modulator of intracellular Ca(2+) function in the neuronal growth cone...
  49. Gorbushin A, Panchin Y, Iakovleva N. In search of the origin of FREPs: characterization of Aplysia californica fibrinogen-related proteins. Dev Comp Immunol. 2010;34:465-73 pubmed publisher
    ..Using genomic WGS database we have found two FREP genes from marine opistobranch Aplysia californica named AcFREP1 and AcFREP2...
  50. Si K, Choi Y, White Grindley E, Majumdar A, Kandel E. Aplysia CPEB can form prion-like multimers in sensory neurons that contribute to long-term facilitation. Cell. 2010;140:421-35 pubmed publisher
    ..Previously we found that a translation regulator CPEB from Aplysia, ApCPEB, that stabilizes activity-dependent changes in synaptic efficacy can display prion-like properties in ..
  51. Fiedler T, Hudder A, McKay S, Shivkumar S, Capo T, Schmale M, et al. The transcriptome of the early life history stages of the California Sea Hare Aplysia californica. Comp Biochem Physiol Part D Genomics Proteomics. 2010;5:165-70 pubmed publisher
    b>Aplysia californica is a marine opisthobranch mollusc used as a model organism in neurobiology for cellular analyses of learning and behavior because it possesses a comparatively small number of neurons of large size...
  52. Hart A, Fioravante D, Liu R, Phares G, Cleary L, Byrne J. Serotonin-mediated synapsin expression is necessary for long-term facilitation of the Aplysia sensorimotor synapse. J Neurosci. 2011;31:18401-11 pubmed publisher
    Serotonin (5-HT)-induced long-term facilitation (LTF) of the Aplysia sensorimotor synapse depends on enhanced gene expression and protein synthesis, but identification of the genes whose expression and regulation are necessary for LTF ..
  53. Acheampong A, Kelly K, Shields Johnson M, Hajovsky J, Wainwright M, Mozzachiodi R. Rapid and persistent suppression of feeding behavior induced by sensitization training in Aplysia. Learn Mem. 2012;19:159-63 pubmed publisher
    In Aplysia, noxious stimuli induce sensitization of defensive responses. However, it remains largely unknown whether such stimuli also alter nondefensive behaviors. In this study, we examined the effects of noxious stimuli on feeding...
  54. Puthanveettil S, Antonov I, Kalachikov S, Rajasethupathy P, Choi Y, Kohn A, et al. A strategy to capture and characterize the synaptic transcriptome. Proc Natl Acad Sci U S A. 2013;110:7464-9 pubmed publisher
    ..Using this strategy in Aplysia, we have identified 5,657 unique sequences consisting of both coding and noncoding RNAs from the CNS...
  55. Ulens C, Hogg R, Celie P, Bertrand D, Tsetlin V, Smit A, et al. Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP. Proc Natl Acad Sci U S A. 2006;103:3615-20 pubmed
    ..Here, we present the 2.2-A crystal structure of a homolog of the ligand-binding domain of the nAChR, Aplysia californica AChBP (Ac-AChBP), in complex with alpha-conotoxin ImI...
  56. Chin J, Liu R, Cleary L, Eskin A, Byrne J. TGF-beta1-induced long-term changes in neuronal excitability in aplysia sensory neurons depend on MAPK. J Neurophysiol. 2006;95:3286-90 pubmed
    ..It induces long-term increases in sensory neuron excitability in Aplysia as well as a long-term enhancement of synaptic efficacy at sensorimotor synapses...
  57. Baxter D, Byrne J. Feeding behavior of Aplysia: a model system for comparing cellular mechanisms of classical and operant conditioning. Learn Mem. 2006;13:669-80 pubmed
    Feeding behavior of Aplysia provides an excellent model system for analyzing and comparing mechanisms underlying appetitive classical conditioning and reward operant conditioning...
  58. Nagahama T, Suzuki T, Yoshikawa S, Iseki M. Functional transplant of photoactivated adenylyl cyclase (PAC) into Aplysia sensory neurons. Neurosci Res. 2007;59:81-8 pubmed
    ..we attempted functional transplant of a photoactivated adenylyl cyclase (PAC) isolated from Euglena into Aplysia neurons, and explored whether PAC can produce cAMP in the neurons by light stimulation...
  59. Zimmerman T, Rubakhin S, Romanova E, Tucker K, Sweedler J. MALDI mass spectrometric imaging using the stretched sample method to reveal neuropeptide distributions in aplysia nervous tissue. Anal Chem. 2009;81:9402-9 pubmed publisher
    ..that enable the imaging of stretched tissues and reveal neuropeptide distributions in nervous tissue from Aplysia californica...
  60. Shemesh O, Spira M. Hallmark cellular pathology of Alzheimer's disease induced by mutant human tau expression in cultured Aplysia neurons. Acta Neuropathol. 2010;120:209-22 pubmed publisher
    ..Here, we introduce the advantageous use of cultured Aplysia neurons (which express over 100 disease-related gene homologs shared with mammals), as a platform to study cell ..
  61. Jin I, Kandel E, Hawkins R. Whereas short-term facilitation is presynaptic, intermediate-term facilitation involves both presynaptic and postsynaptic protein kinases and protein synthesis. Learn Mem. 2011;18:96-102 pubmed publisher
    ..Consistent with that idea, although short-term term behavioral sensitization in Aplysia involves presynaptic mechanisms, intermediate-term sensitization involves both pre- and postsynaptic mechanisms...
  62. Zhong M, Lee C, Croushore C, Sweedler J. Label-free quantitation of peptide release from neurons in a microfluidic device with mass spectrometry imaging. Lab Chip. 2012;12:2037-45 pubmed publisher
    ..Using appropriate calibrations, we determined that an individual Aplysia bag cell neuron secretes 0.15 ± 0.03 pmol of AP and 0.13 ± 0...
  63. Heyland A, Plachetzki D, Donelly E, Gunaratne D, Bobkova Y, Jacobson J, et al. Distinct expression patterns of glycoprotein hormone subunits in the lophotrochozoan Aplysia: implications for the evolution of neuroendocrine systems in animals. Endocrinology. 2012;153:5440-51 pubmed publisher
    ..we cloned and analyzed phylogenetically two glycoprotein subunits, AcaGPH? and AcaGPH?, from the sea hare Aplysia californica...
  64. Bai L, Livnat I, Romanova E, Alexeeva V, Yau P, Vilim F, et al. Characterization of GdFFD, a D-amino acid-containing neuropeptide that functions as an extrinsic modulator of the Aplysia feeding circuit. J Biol Chem. 2013;288:32837-51 pubmed publisher
    ..We describe a multipronged approach to overcome these limitations using the sea slug Aplysia californica...
  65. Hawkins R, Cohen T, Kandel E. Dishabituation in Aplysia can involve either reversal of habituation or superimposed sensitization. Learn Mem. 2006;13:397-403 pubmed
    ..Previous studies using this approach in Aplysia have come to different conclusions about the nature of dishabituation, perhaps because those studies differed in ..
  66. Zhang B, Muller Steffner H, Schuber F, Potter B. Nicotinamide 2-fluoroadenine dinucleotide unmasks the NAD+ glycohydrolase activity of Aplysia californica adenosine 5'-diphosphate ribosyl cyclase. Biochemistry. 2007;46:4100-9 pubmed
    ..The invertebrate Aplysia californica ADP-ribosyl cyclase is unusual among this family of enzymes by acting exclusively as a cyclase, ..
  67. Burnette D, Schaefer A, Ji L, Danuser G, Forscher P. Filopodial actin bundles are not necessary for microtubule advance into the peripheral domain of Aplysia neuronal growth cones. Nat Cell Biol. 2007;9:1360-9 pubmed
    ..The resulting dynamic steady state has interesting implications for rapid microtubule-positioning responses in the P domain...
  68. Sasaki K, Jing J, Due M, Weiss K. An input-representing interneuron regulates spike timing and thereby phase switching in a motor network. J Neurosci. 2008;28:1916-28 pubmed publisher
    ..In the Aplysia feeding network, we show that interneuron B65 regulates the timing of the spike initiation of phase-switch ..
  69. Talley T, Harel M, Hibbs R, Radic Z, Tomizawa M, Casida J, et al. Atomic interactions of neonicotinoid agonists with AChBP: molecular recognition of the distinctive electronegative pharmacophore. Proc Natl Acad Sci U S A. 2008;105:7606-11 pubmed publisher
    ..Comparisons of the neonicotinoids imidacloprid and thiacloprid in the binding site from Aplysia californica AChBP at 2.48 and 1...
  70. Lee Y, Bailey C, Kandel E, Kaang B. Transcriptional regulation of long-term memory in the marine snail Aplysia. Mol Brain. 2008;1:3 pubmed publisher
    ..molecular features of transcriptional regulation involved in the long-term process are evolutionally conserved in Aplysia, Drosophila, and mouse, and indicate that gene regulation by the cyclic AMP response element binding protein (..
  71. Hu J, Chen Y, Bougie J, Sossin W, Schacher S. Aplysia cell adhesion molecule and a novel protein kinase C activity in the postsynaptic neuron are required for presynaptic growth and initial formation of specific synapses. J Neurosci. 2010;30:8353-66 pubmed publisher
    To explore the role of both Aplysia cell adhesion molecule (ApCAM) and activity of specific protein kinase C (PKC) isoforms in the initial formation of sensory neuron synapses with specific postsynaptic targets (L7 but not L11), we ..
  72. Weatherill D, McCamphill P, Pethoukov E, Dunn T, Fan X, Sossin W. Compartment-specific, differential regulation of eukaryotic elongation factor 2 and its kinase within Aplysia sensory neurons. J Neurochem. 2011;117:841-55 pubmed publisher
    Long-term facilitation (LTF) in Aplysia is a leading model for elucidating the biochemical mechanisms of synaptic plasticity underlying learning. LTF requires translational control downstream of target of rapamycin complex 1...
  73. Liu R, Shah S, Cleary L, Byrne J. Serotonin- and training-induced dynamic regulation of CREB2 in Aplysia. Learn Mem. 2011;18:245-9 pubmed publisher
    Long-term memory and plasticity, including long-term synaptic facilitation (LTF) of the Aplysia sensorimotor synapse, depend on the activation of transcription factors that regulate genes necessary for synaptic plasticity...
  74. Choi Y, Li H, Kassabov S, Jin I, Puthanveettil S, Karl K, et al. Neurexin-neuroligin transsynaptic interaction mediates learning-related synaptic remodeling and long-term facilitation in aplysia. Neuron. 2011;70:468-81 pubmed publisher
    ..explored the role of neurexin and neuroligin at sensory-to-motor neuron synapses of the gill-withdrawal reflex in Aplysia, which undergoes sensitization, a simple form of learned fear...
  75. Fan Y, Rubakhin S, Sweedler J. Collection of peptides released from single neurons with particle-embedded monolithic capillaries followed by detection with matrix-assisted laser desorption/ionization mass spectrometry. Anal Chem. 2011;83:9557-63 pubmed publisher
    ..were positioned in close proximity to individual neurons and 50 mM KCl was used as the secretagogue, peptides released from individual identified cultured neurons isolated from Aplysia californica were collected and characterized.
  76. Hawkins R, Clark G, Kandel E. Operant conditioning of gill withdrawal in Aplysia. J Neurosci. 2006;26:2443-8 pubmed
    ..To further address that question, we examined whether gill withdrawal in Aplysia, which has already been studied extensively for neuronal mechanisms contributing to habituation, sensitization, ..
  77. Katzoff A, Ben Gedalya T, Hurwitz I, Miller N, Susswein Y, Susswein A. Nitric oxide signals that aplysia have attempted to eat, a necessary component of memory formation after learning that food is inedible. J Neurophysiol. 2006;96:1247-57 pubmed
    Inhibiting nitric oxide (NO) synthesis during learning that food is inedible in Aplysia blocks subsequent memory formation...
  78. Weragoda R, Walters E. Serotonin induces memory-like, rapamycin-sensitive hyperexcitability in sensory axons of aplysia that contributes to injury responses. J Neurophysiol. 2007;98:1231-9 pubmed
    The induction of long-term facilitation (LTF) of synapses of Aplysia sensory neurons (SNs) by serotonin (5-HT) has provided an important mechanistic model of memory, but little is known about other long-term effects of 5-HT on sensory ..
  79. Villareal G, Li Q, Cai D, Glanzman D. The role of rapid, local, postsynaptic protein synthesis in learning-related synaptic facilitation in aplysia. Curr Biol. 2007;17:2073-80 pubmed
    ..Accordingly, we examined whether learning in an invertebrate, the marine snail Aplysia, involves local, postsynaptic protein synthesis...
  80. Tramice A, Andreotti G, Trincone A. Direct enzymatic glucosylation of naringin in grapefruit juice by alpha-D-glucosidase from the marine mollusc Aplysia fasciata. Biotechnol J. 2008;3:545-54 pubmed
    ..glucosylations of naringin, performed using alpha-D-glucosidase, identified in the Mediterranean mollusc Aplysia fasciata is reported...
  81. Glanzman D. Habituation in Aplysia: the Cheshire cat of neurobiology. Neurobiol Learn Mem. 2009;92:147-54 pubmed publisher
    The marine snail, Aplysia californica, is a valuable model system for cell biological studies of learning and memory...
  82. Wang D, Kim S, Zhao Y, Hwang H, Miura S, Sossin W, et al. Synapse- and stimulus-specific local translation during long-term neuronal plasticity. Science. 2009;324:1536-40 pubmed publisher
    ..translational reporters, we directly visualized local translation at synapses during long-term facilitation of Aplysia sensory-motor synapses...
  83. Malkinson G, Spira M. Imaging and analysis of evoked excitatory-postsynaptic-calcium-transients by individual presynaptic-boutons of cultured Aplysia sensorimotor synapse. Cell Calcium. 2010;47:315-25 pubmed publisher
    The use of the sensory-motor (SN-MN) synapse of the Aplysia gill withdrawal reflex has contributed immensely to the understanding of synaptic transmission, learning and memory acquisition processes...
  84. Nagakura I, Dunn T, Farah C, Heppner A, Li F, Sossin W. Regulation of protein kinase C Apl II by serotonin receptors in Aplysia. J Neurochem. 2010;115:994-1006 pubmed publisher
    Serotonin (5-hydroxytryptamine, 5HT) is the neurotransmitter that mediates dishabituation in Aplysia. Serotonin mediates this behavioral change through the reversal of synaptic depression in sensory neurons (SNs)...
  85. Heinrich S, Lindquist S. Protein-only mechanism induces self-perpetuating changes in the activity of neuronal Aplysia cytoplasmic polyadenylation element binding protein (CPEB). Proc Natl Acad Sci U S A. 2011;108:2999-3004 pubmed publisher
    ..To investigate, we take advantage of yeast cells wherein the neuronal CPEB of Aplysia is expressed in the absence of any neuronal factors and can stably adopt either an active or an inactive state...
  86. Shields Johnson M, Hernandez J, Torno C, Adams K, Wainwright M, Mozzachiodi R. Effects of aversive stimuli beyond defensive neural circuits: reduced excitability in an identified neuron critical for feeding in Aplysia. Learn Mem. 2012;20:1-5 pubmed publisher
    In Aplysia, repeated trials of aversive stimuli produce long-term sensitization (LTS) of defensive reflexes and suppression of feeding...
  87. Hawkins R, Kandel E, Bailey C. Molecular mechanisms of memory storage in Aplysia. Biol Bull. 2006;210:174-91 pubmed
    ..that underlie short-term, intermediate-term, and long-term forms of implicit memory in the marine invertebrate Aplysia californica, and consider how the conservation of common elements in each form may contribute to the different ..
  88. Lyons L, Rawashdeh O, Eskin A. Non-ocular circadian oscillators and photoreceptors modulate long term memory formation in Aplysia. J Biol Rhythms. 2006;21:245-55 pubmed
    In Aplysia californica, memory formation for long-term sensitization (LTS) and for a more complex type of associative learning, learning that food is inedible (LFI), is modulated by a circadian clock...
  89. Romanova E, Roth M, Rubakhin S, Jakubowski J, Kelley W, Kirk M, et al. Identification and characterization of homologues of vertebrate beta-thymosin in the marine mollusk Aplysia californica. J Mass Spectrom. 2006;41:1030-40 pubmed publisher
    ..beta-thymosin(Gln), have been de novo sequenced by top-down mass spectrometry in the common neurobiology model, Aplysia californica...
  90. Ye H, Morton D, Chiel H. Neuromechanics of multifunctionality during rejection in Aplysia californica. J Neurosci. 2006;26:10743-55 pubmed
    ..this question by analyzing the biomechanical and neural mechanisms of rejection responses in the marine mollusk Aplysia californica and compared these mechanisms with those used to generate swallowing responses (Ye et al., 2006)...
  91. Zhang B, Wagner G, Weber K, Garnham C, Morgan A, Galione A, et al. 2'-deoxy cyclic adenosine 5'-diphosphate ribose derivatives: importance of the 2'-hydroxyl motif for the antagonistic activity of 8-substituted cADPR derivatives. J Med Chem. 2008;51:1623-36 pubmed publisher
    ..b>Aplysia californica ADP-ribosyl cyclase tolerates even the bulky 8-phenyl-nicotinamide adenine 5'-dinucleotide as a ..
  92. Miniaci M, Kim J, Puthanveettil S, Si K, Zhu H, Kandel E, et al. Sustained CPEB-dependent local protein synthesis is required to stabilize synaptic growth for persistence of long-term facilitation in Aplysia. Neuron. 2008;59:1024-36 pubmed publisher
    ..the stabilization of learning-related synaptic growth and the persistence of long-term memory was examined using Aplysia bifurcated sensory neuron-motor neuron cultures...