schistosoma mansoni

Summary

Summary: A species of trematode blood flukes of the family Schistosomatidae. It is common in the Nile delta. The intermediate host is the planorbid snail. This parasite causes schistosomiasis mansoni and intestinal bilharziasis.

Top Publications

  1. Tukahebwa E, Vennervald B, Nuwaha F, Kabatereine N, Magnussen P. Comparative efficacy of one versus two doses of praziquantel on cure rate of Schistosoma mansoni infection and re-infection in Mayuge District, Uganda. Trans R Soc Trop Med Hyg. 2013;107:397-404 pubmed publisher
    ..We assessed the effect of one versus two doses of praziquantel on cure rate and re-infection with Schistosoma mansoni in a high endemic community along Lake Victoria, Uganda...
  2. Skinner D, Rinaldi G, Suttiprapa S, Mann V, Smircich P, Cogswell A, et al. Vasa-Like DEAD-Box RNA Helicases of Schistosoma mansoni. PLoS Negl Trop Dis. 2012;6:e1686 pubmed publisher
    ..Germ cell specific expression of schistosome vasa-like genes should provide an informative landmark for germ line transgenesis of schistosomes, etiologic agents of major neglected tropical diseases. ..
  3. Ittiprasert W, Knight M. Reversing the resistance phenotype of the Biomphalaria glabrata snail host Schistosoma mansoni infection by temperature modulation. PLoS Pathog. 2012;8:e1002677 pubmed publisher
    ..glabrata snails that display either resistant or susceptible phenotypes to the parasitic trematode, Schistosoma mansoni provide an invaluable resource towards elucidating the molecular basis of the snail-host/schistosome ..
  4. Peterson N, Anderson T, Yoshino T. In silico analysis of the fucosylation-associated genome of the human blood fluke Schistosoma mansoni: cloning and characterization of the fucosyltransferase multigene family. PLoS ONE. 2013;8:e63299 pubmed publisher
    Fucosylated glycans of the parasitic flatworm Schistosoma mansoni play key roles in its development and immunobiology...
  5. van Diepen A, Smit C, van Egmond L, Kabatereine N, Pinot de Moira A, Dunne D, et al. Differential anti-glycan antibody responses in Schistosoma mansoni-infected children and adults studied by shotgun glycan microarray. PLoS Negl Trop Dis. 2012;6:e1922 pubmed publisher
    ..mansoni infections. These findings are significant for further exploration of Schistosoma glycan antigens in relation to immunity. ..
  6. Martins Souza R, Pereira C, Rodrigues L, Araújo E, Coelho P, Correa A, et al. Participation of N-acetyl-D-glucosamine carbohydrate moieties in the recognition of Schistosoma mansoni sporocysts by haemocytes of Biomphalaria tenagophila. Mem Inst Oswaldo Cruz. 2011;106:884-91 pubmed
    Lectin-carbohydrate binding may be involved in the recognition of Schistosoma mansoni sporocysts by haemocytes of Biomphalaria; therefore, we tested if this interaction is associated with snail resistance against Schistosoma infection...
  7. Everts B, Hussaarts L, Driessen N, Meevissen M, Schramm G, van der Ham A, et al. Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor. J Exp Med. 2012;209:1753-67, S1 pubmed
    Omega-1, a glycosylated T2 ribonuclease (RNase) secreted by Schistosoma mansoni eggs and abundantly present in soluble egg antigen, has recently been shown to condition dendritic cells (DCs) to prime Th2 responses...
  8. Grenfell R, Harn D, Tundup S, Da dara A, Siqueira L, Coelho P. New approaches with different types of circulating cathodic antigen for the diagnosis of patients with low Schistosoma mansoni load. PLoS Negl Trop Dis. 2013;7:e2054 pubmed publisher
    ..Recently, focus has been given to highly purified Schistosoma mansoni antigens, especially to circulating antigens...
  9. El Lakkany N, Hammam O, El Maadawy W, Badawy A, Ain Shoka A, Ebeid F. Anti-inflammatory/anti-fibrotic effects of the hepatoprotective silymarin and the schistosomicide praziquantel against Schistosoma mansoni-induced liver fibrosis. Parasit Vectors. 2012;5:9 pubmed publisher
    ..This study investigates the anti-inflammatory/anti-fibrotic effects of silymarin and/or PZQ on schistosomal hepatic fibrosis...

More Information

Publications93

  1. Figueiredo J, Oliveira R, Cardoso L, Barnes K, Grant A, Carvalho E, et al. Adult worm-specific IgE/IgG4 balance is associated with low infection levels of Schistosoma mansoni in an endemic area. Parasite Immunol. 2012;34:604-10 pubmed publisher
    Field studies have suggested an immune-mediated mechanism associated with resistance to Schistosoma mansoni infection...
  2. Araujo J, de Melo T, de Sena I, Alves C, Araujo N, Durães F, et al. Schistosoma mansoni schistosomula tegument (Smteg) immunization in absence of adjuvant induce IL-10 production by CD4+ cells and failed to protect mice against challenge infection. Acta Trop. 2012;124:140-6 pubmed publisher
    The Schistosoma mansoni tegument interaction with the immune system plays a key role in disease establishment or elimination. We have recently demonstrated that S...
  3. de Saram P, Ressurreição M, Davies A, Rollinson D, Emery A, Walker A. Functional mapping of protein kinase A reveals its importance in adult Schistosoma mansoni motor activity. PLoS Negl Trop Dis. 2013;7:e1988 pubmed publisher
    ..exclusively detect activated PKA, we provide a detailed in situ analysis of PKA signalling in intact adult Schistosoma mansoni, a causative agent of debilitating human intestinal schistosomiasis...
  4. Seto E, Sousa Figueiredo J, Betson M, Byalero C, Kabatereine N, Stothard J. Patterns of intestinal schistosomiasis among mothers and young children from Lake Albert, Uganda: water contact and social networks inferred from wearable global positioning system dataloggers. Geospat Health. 2012;7:1-13 pubmed
    ..We believe that this should now be formally considered within NCP, which may benefit from more in-depth ethnographic exploration of factors related to water contact as this should provide new opportunities for sustaining control...
  5. Oliveira K, Carvalho M, Verjovski Almeida S, LoVerde P. Effect of human TGF-? on the gene expression profile of Schistosoma mansoni adult worms. Mol Biochem Parasitol. 2012;183:132-9 pubmed publisher
    b>Schistosoma mansoni is responsible for schistosomiasis, a parasitic disease that affects 200 million people worldwide...
  6. Pinot de Moira A, Sousa Figueiredo J, Jones F, Fitzsimmons C, Betson M, Kabatereine N, et al. Schistosoma mansoni infection in preschool-aged children: development of immunoglobulin E and immunoglobulin G4 responses to parasite allergen-like proteins. J Infect Dis. 2013;207:362-6 pubmed publisher
    ..proteins SmTAL1 and SmTAL2 among preschool-aged children from 2 villages with different levels of Schistosoma mansoni transmission...
  7. Mohamed A, El Din A, Mohamed A, Habib M. The relationship between genetic variability and the susceptibility of Biomphalaria alexandrina snails to Schistosoma mansoni infection. Mem Inst Oswaldo Cruz. 2012;107:326-37 pubmed
    ..Experimental infection of the F? of progeny from the collected snails with Schistosoma mansoni (SBSC strain) showed variable susceptibility rates ranging from 15% in the Fayoum snail group to 50...
  8. Perona Wright G, Lundie R, Jenkins S, Webb L, Grencis R, MacDonald A. Concurrent bacterial stimulation alters the function of helminth-activated dendritic cells, resulting in IL-17 induction. J Immunol. 2012;188:2350-8 pubmed publisher
  9. Ugbomoiko U, Dalumo V, Danladi Y, Heukelbach J, Ofoezie I. Concurrent urinary and intestinal schistosomiasis and intestinal helminthic infections in schoolchildren in Ilobu, South-western Nigeria. Acta Trop. 2012;123:16-21 pubmed publisher
    ..and intensity of soil-transmitted nematodes and the co-occurrence with Schistosoma haematobium and Schistosoma mansoni. Urine and stool samples from 419 schoolchildren were examined, and a questionnaire was administered to ..
  10. Lockyer A, Emery A, Kane R, Walker A, Mayer C, Mitta G, et al. Early differential gene expression in haemocytes from resistant and susceptible Biomphalaria glabrata strains in response to Schistosoma mansoni. PLoS ONE. 2012;7:e51102 pubmed publisher
    The outcome of infection in the host snail Biomphalaria glabrata with the digenean parasite Schistosoma mansoni is determined by the initial molecular interplay occurring between them...
  11. Espírito Santo M, Alvarado Mora M, Pinto P, Carrilho F, Pinho J, Gryschek R. Two sequential PCR amplifications for detection of Schistosoma mansoni in stool samples with low parasite load. Rev Inst Med Trop Sao Paulo. 2012;54:245-8 pubmed
    ..The aim of this study is to present the PCR reamplification (Re-PCR) protocol for the detection of Schistosoma mansoni in samples with low parasite load (with less than 100 eggs per gram (epg) of feces)...
  12. Coulibaly J, N Goran E, Utzinger J, Doenhoff M, Dawson E. A new rapid diagnostic test for detection of anti-Schistosoma mansoni and anti-Schistosoma haematobium antibodies. Parasit Vectors. 2013;6:29 pubmed publisher
    ..antibodies have the merit of high sensitivity and recently a rapid diagnostic test (RDT), incorporating Schistosoma mansoni cercarial transformation fluid (SmCTF) for detection of anti-schistosome antibodies in blood has been ..
  13. Sousa Figueiredo J, Betson M, Atuhaire A, Arinaitwe M, Navaratnam A, Kabatereine N, et al. Performance and safety of praziquantel for treatment of intestinal schistosomiasis in infants and preschool children. PLoS Negl Trop Dis. 2012;6:e1864 pubmed publisher
    ..We have formally assessed parasitological cure and putative side-effects in a prospective cohort of Schistosoma mansoni-infected children (aged 5 months-7 years old) in lakeshore settings of Uganda.
  14. Ahmad G, Zhang W, Torben W, Ahrorov A, Damian R, Wolf R, et al. Preclinical prophylactic efficacy testing of Sm-p80-based vaccine in a nonhuman primate model of Schistosoma mansoni infection and immunoglobulin G and E responses to Sm-p80 in human serum samples from an area where schistosomiasis is endemic. J Infect Dis. 2011;204:1437-49 pubmed publisher
    ..This study provided the proof of concept to move Sm-p80 forward into further preclinical development leading to human clinical trials...
  15. Hahnel S, Lu Z, Wilson R, Grevelding C, Quack T. Whole-organ isolation approach as a basis for tissue-specific analyses in Schistosoma mansoni. PLoS Negl Trop Dis. 2013;7:e2336 pubmed publisher
    ..protocol using a combined detergent/protease-treatment removing the tegument and the musculature of adult Schistosoma mansoni. All steps were monitored by scanning electron microscopy (SEM) and bright-field microscopy (BF)...
  16. Truscott M, Evans D, Gunn M, Hoffmann K. Schistosoma mansoni hemozoin modulates alternative activation of macrophages via specific suppression of Retnla expression and secretion. Infect Immun. 2013;81:133-42 pubmed publisher
    The trematode Schistosoma mansoni is one of the etiological agents of schistosomiasis, a key neglected tropical disease responsible for an estimated annual loss of 70 million disability-adjusted life years...
  17. Silva L, Marcet Houben M, Zerlotini A, Gabaldón T, Oliveira G, Nahum L. Evolutionary histories of expanded peptidase families in Schistosoma mansoni. Mem Inst Oswaldo Cruz. 2011;106:864-77 pubmed
    b>Schistosoma mansoni is one of the three main causative agents of human schistosomiasis, a major health problem with a vast socio-economic impact...
  18. Taman A, Ribeiro P. Characterization of a truncated metabotropic glutamate receptor in a primitive metazoan, the parasitic flatworm Schistosoma mansoni. PLoS ONE. 2011;6:e27119 pubmed publisher
    A novel glutamate-binding protein was identified in Schistosoma mansoni. The protein (SmGBP) is related to metabotropic glutamate receptors from other species and has a predicted glutamate binding site located within a Venus Flytrap ..
  19. Fairfax K, Everts B, Smith A, Pearce E. Regulation of the development of the hepatic B cell compartment during Schistosoma mansoni infection. J Immunol. 2013;191:4202-10 pubmed publisher
    During infection with the helminth parasite Schistosoma mansoni, Ab regulates hepatic inflammation, and local production of Ig in the liver appears to play a role in this process...
  20. Samuels A, Matey E, Mwinzi P, Wiegand R, Muchiri G, Ireri E, et al. Schistosoma mansoni morbidity among school-aged children: a SCORE project in Kenya. Am J Trop Med Hyg. 2012;87:874-82 pubmed publisher
    ..twenty-two schoolchildren 7-8 years of age from Nyanza Province, Kenya, contributed stool for diagnosis of Schistosoma mansoni and soil-transmitted helminths (STH) and blood smears for malaria, and were evaluated for anemia, quality ..
  21. Lodh N, Mwansa J, Mutengo M, Shiff C. Diagnosis of Schistosoma mansoni without the stool: comparison of three diagnostic tests to detect Schistosoma [corrected] mansoni infection from filtered urine in Zambia. Am J Trop Med Hyg. 2013;89:46-50 pubmed publisher
    Diagnosis for intestinal Schistosoma mansoni lacks sensitivity and is arduous to conduct...
  22. El Ridi R, Tallima H. Vaccine-induced protection against murine schistosomiasis mansoni with larval excretory-secretory antigens and papain or type-2 cytokines. J Parasitol. 2013;99:194-202 pubmed publisher
    b>Schistosoma mansoni glyceraldehyde 3-phosphate dehydrogenase (SG3PDH), peroxiredoxin (TPX), and other larval excretory-secretory products (ESP) essentially induce T helper (Th) 1 and Th17 immune responses during a non-protective natural ..
  23. Rinaldi G, Eckert S, Tsai I, Suttiprapa S, Kines K, Tort J, et al. Germline transgenesis and insertional mutagenesis in Schistosoma mansoni mediated by murine leukemia virus. PLoS Pathog. 2012;8:e1002820 pubmed publisher
    ..characterization of role and essentiality of newly available genome sequences of the human schistosomes, Schistosoma mansoni, S. japonicum and S. haematobium...
  24. Betson M, Sousa Figueiredo J, Kabatereine N, Stothard J. Use of fecal occult blood tests as epidemiologic indicators of morbidity associated with intestinal schistosomiasis during preventive chemotherapy in young children. Am J Trop Med Hyg. 2012;87:694-700 pubmed publisher
    ..We therefore propose that FOB is useful for assessing dynamics of intestinal morbidity in young children at the community level and monitoring changes in morbidity after mass chemotherapy...
  25. Webster B, Webster J, Gouvras A, Garba A, Lamine M, Diaw O, et al. DNA 'barcoding' of Schistosoma mansoni across sub-Saharan Africa supports substantial within locality diversity and geographical separation of genotypes. Acta Trop. 2013;128:250-60 pubmed publisher
    b>Schistosoma mansoni is a widespread human helminth and causes intestinal schistosomiasis in 54 countries, mainly across Africa but also in Madagascar, the Arabian Peninsula and the neotropics...
  26. Suttiprapa S, Rinaldi G, Brindley P. Prototypic chromatin insulator cHS4 protects retroviral transgene from silencing in Schistosoma mansoni. Transgenic Res. 2012;21:555-66 pubmed publisher
    ..Cultured larvae of Schistosoma mansoni were transduced with virions from producer cells transfected with control or cHS4-bearing plasmids...
  27. Lancelot J, Caby S, Dubois Abdesselem F, Vanderstraete M, Trolet J, Oliveira G, et al. Schistosoma mansoni Sirtuins: characterization and potential as chemotherapeutic targets. PLoS Negl Trop Dis. 2013;7:e2428 pubmed publisher
    ..In order to determine whether Schistosoma mansoni sirtuins are potential therapeutic targets we first identified and characterized their protein sequences...
  28. Meurs L, Mbow M, Boon N, Van den Broeck F, Vereecken K, Dieye T, et al. Micro-geographical heterogeneity in Schistosoma mansoni and S. haematobium infection and morbidity in a co-endemic community in northern Senegal. PLoS Negl Trop Dis. 2013;7:e2608 pubmed publisher
    b>Schistosoma mansoni and S. haematobium are co-endemic in many areas in Africa. Yet, little is known about the micro-geographical distribution of these two infections or associated disease within such foci...
  29. King C, Olbrych S, Soon M, Singer M, Carter J, Colley D. Utility of repeated praziquantel dosing in the treatment of schistosomiasis in high-risk communities in Africa: a systematic review. PLoS Negl Trop Dis. 2011;5:e1321 pubmed publisher
    ..In a systematic review of published studies, we examined evidence for incremental benefits from repeated praziquantel dosing, given 2 to 8 weeks after an initial dose, in Schistosoma-endemic areas of Africa...
  30. Duvoisin R, Ayuk M, Rinaldi G, Suttiprapa S, Mann V, Lee C, et al. Human U6 promoter drives stronger shRNA activity than its schistosome orthologue in Schistosoma mansoni and human fibrosarcoma cells. Transgenic Res. 2012;21:511-21 pubmed publisher
    ..Following transduction of both HT1080 fibrosarcoma cells and schistosomules of Schistosoma mansoni with pseudotyped MLV virions, stronger knockdown of luciferase activity was seen with the virions encoding ..
  31. Fitzsimmons C, Jones F, Stearn A, Chalmers I, Hoffmann K, Wawrzyniak J, et al. The Schistosoma mansoni tegumental-allergen-like (TAL) protein family: influence of developmental expression on human IgE responses. PLoS Negl Trop Dis. 2012;6:e1593 pubmed publisher
    A human IgE response to Sm22.6 (a dominant IgE target in Schistosoma mansoni) is associated with the development of partial immunity...
  32. Ingram J, Rafi S, Eroy Reveles A, Ray M, Lambeth L, Hsieh I, et al. Investigation of the proteolytic functions of an expanded cercarial elastase gene family in Schistosoma mansoni. PLoS Negl Trop Dis. 2012;6:e1589 pubmed publisher
    Cercarial elastase is the major invasive larval protease in Schistosoma mansoni, a parasitic blood fluke, and is essential for host skin invasion...
  33. Torben W, Ahmad G, Zhang W, Nash S, Le L, Karmakar S, et al. Role of antibody dependent cell mediated cytotoxicity (ADCC) in Sm-p80-mediated protection against Schistosoma mansoni. Vaccine. 2012;30:6753-8 pubmed publisher
    ..In this regard, Sm-p80 mediated protection against intestinal schistosomiasis caused by Schistosoma mansoni has been observed to be promising in two animal models of infection and disease...
  34. Elhag S, Abdelkareem E, Yousif A, Frah E, Mohamed A. Detection of schistosomiasis antibodies in urine patients as a promising diagnostic maker. Asian Pac J Trop Med. 2011;4:773-7 pubmed publisher
    ..Statistically no significant difference between the IgG levels in serum and urine samples was observed. This study shows that the detection of secreted IgG antibodies in urine can substitute serum for diagnosis of schistosomiasis. ..
  35. Graham B, Chabon J, Gebreab L, Poole J, Debella E, Davis L, et al. Transforming growth factor-? signaling promotes pulmonary hypertension caused by Schistosoma mansoni. Circulation. 2013;128:1354-64 pubmed publisher
    ..We hypothesized that transforming growth factor-? (TGF-?) signaling as a consequence of Th2 inflammation is critical for the pathogenesis of this disease...
  36. Khalid A, Abdelgadir M, Ashmaig A, Ibrahim A, Ahmed A, Adam I. Schistosoma mansoni infection among prenatal attendees at a secondary-care hospital in central Sudan. Int J Gynaecol Obstet. 2012;116:10-2 pubmed publisher
    To investigate the epidemiology of Schistosoma mansoni infection among pregnant women in a secondary-care hospital in Geizera state, Sudan.
  37. Fitzsimmons C, Jones F, Pinot de Moira A, Protasio A, Khalife J, Dickinson H, et al. Progressive cross-reactivity in IgE responses: an explanation for the slow development of human immunity to schistosomiasis?. Infect Immun. 2012;80:4264-70 pubmed publisher
    People in regions of Schistosoma mansoni endemicity slowly acquire immunity, but why this takes years to develop is still not clear...
  38. Tweyongyere R, Mawa P, Kihembo M, Jones F, Webb E, Cose S, et al. Effect of praziquantel treatment of Schistosoma mansoni during pregnancy on immune responses to schistosome antigens among the offspring: results of a randomised, placebo-controlled trial. BMC Infect Dis. 2011;11:234 pubmed publisher
    ..controlled-trials.com/ISRCTN32849447/elliott), offspring of women with Schistosoma mansoni were examined for cytokine and antibody responses to schistosome worm (SWA) and egg (SEA) antigen, in cord ..
  39. Abay S, Tilahun M, Fikrie N, Habtewold A. Plasmodium falciparum and Schistosoma mansoni coinfection and the side benefit of artemether-lumefantrine in malaria patients. J Infect Dev Ctries. 2013;7:468-74 pubmed publisher
    ..This study aimed to investigate the extent of malaria-schistosomiasis co-infection and the antischistosomal effect of artemether-lumefantrine when administered to treat falciparum malaria in Kemise, Northeast Ethiopia...
  40. El Shehabi F, Taman A, Moali L, El Sakkary N, Ribeiro P. A novel G protein-coupled receptor of Schistosoma mansoni (SmGPR-3) is activated by dopamine and is widely expressed in the nervous system. PLoS Negl Trop Dis. 2012;6:e1523 pubmed publisher
    ..Here we describe a novel Schistosoma mansoni G protein-coupled receptor (named SmGPR-3) that was cloned, expressed heterologously and shown to be ..
  41. Galanti S, Huang S, Pearce E. Cell death and reproductive regression in female Schistosoma mansoni. PLoS Negl Trop Dis. 2012;6:e1509 pubmed publisher
    ..Both processes are negatively affected by removal from the host regardless of whether male worms are present or not, and are unsustainable using standard tissue culture approaches...
  42. Erko B, Medhin G, Teklehaymanot T, Degarege A, Legesse M. Evaluation of urine-circulating cathodic antigen (Urine-CCA) cassette test for the detection of Schistosoma mansoni infection in areas of moderate prevalence in Ethiopia. Trop Med Int Health. 2013;18:1029-35 pubmed publisher
    To evaluate the diagnostic performance of antigen detecting urine-CCA cassette test for the detection of Schistosoma mansoni infection in areas of moderate prevalence in Ethiopia.
  43. Manneck T, Keiser J, Muller J. Mefloquine interferes with glycolysis in schistosomula of Schistosoma mansoni via inhibition of enolase. Parasitology. 2012;139:497-505 pubmed publisher
    ..The mode of action and involved drug targets of mefloquine in Schistosoma mansoni schistosomula are unknown...
  44. Farias L, Rodrigues D, Cunna V, Rofatto H, Faquim Mauro E, Leite L. Schistosoma mansoni venom allergen like proteins present differential allergic responses in a murine model of airway inflammation. PLoS Negl Trop Dis. 2012;6:e1510 pubmed publisher
    The Schistosoma mansoni Venom-Allergen-Like proteins (SmVALs) are members of the SCP/TAPS (Sperm-coating protein/Tpx-1/Ag5/PR-1/Sc7) protein superfamily, which may be important in the host-pathogen interaction...
  45. Patocka N, Ribeiro P. The functional role of a serotonin transporter in Schistosoma mansoni elucidated through immunolocalization and RNA interference (RNAi). Mol Biochem Parasitol. 2013;187:32-42 pubmed publisher
    Serotonin is an important neurotransmitter in both vertebrates and invertebrates. In the parasitic flatworm, Schistosoma mansoni, serotonin stimulates worm movement and potentiates muscle contraction...
  46. Parker Manuel S, Ivens A, Dillon G, Wilson R. Gene expression patterns in larval Schistosoma mansoni associated with infection of the mammalian host. PLoS Negl Trop Dis. 2011;5:e1274 pubmed publisher
    ..Patterns of gene expression underlying this transition have been characterised...
  47. Coulibaly J, N gbesso Y, Knopp S, Keiser J, N Goran E, Utzinger J. Efficacy and safety of praziquantel in preschool-aged children in an area co-endemic for Schistosoma mansoni and S. haematobium. PLoS Negl Trop Dis. 2012;6:e1917 pubmed publisher
    ..Since a pediatric formulation (e.g., syrup) is not available outside of Egypt, crushed praziquantel tablets are used, but the efficacy and safety of this treatment regimen is insufficiently studied...
  48. Odiere M, Rawago F, Ombok M, Secor W, Karanja D, Mwinzi P, et al. High prevalence of schistosomiasis in Mbita and its adjacent islands of Lake Victoria, western Kenya. Parasit Vectors. 2012;5:278 pubmed publisher
    ..Consequently, there is a paucity of data on prevalence of schistosomiasis and soil-transmitted helminth (STH) infections that are endemic in this region...
  49. Lepore R, Simeoni S, Raimondo D, Caroli A, Tramontano A, Via A. Identification of the Schistosoma mansoni molecular target for the antimalarial drug artemether. J Chem Inf Model. 2011;51:3005-16 pubmed publisher
    ..Our analysis of the mode of binding of artemether to Ca²?-ATPases also provides an explanation for the apparent paradox that, although the molecule has no side effect in humans, it has been shown to possess antitumoral activity...
  50. Woodhall D, Wiegand R, Wellman M, Matey E, Abudho B, Karanja D, et al. Use of geospatial modeling to predict Schistosoma mansoni prevalence in Nyanza Province, Kenya. PLoS ONE. 2013;8:e71635 pubmed publisher
    ..are known to contribute to the focal distribution of schistosomiasis, we sought to determine if specific environmental and geographic factors could be used to accurately predict Schistosoma mansoni prevalence in Nyanza Province, Kenya.
  51. Collins J, Wang B, Lambrus B, Tharp M, Iyer H, Newmark P. Adult somatic stem cells in the human parasite Schistosoma mansoni. Nature. 2013;494:476-9 pubmed publisher
    ..Here we describe a population of neoblast-like cells in the trematode Schistosoma mansoni. These cells resemble planarian neoblasts morphologically and share their ability to proliferate and ..
  52. Faro M, Perazzini M, Corrêa L, Mello Silva C, Pinheiro J, Mota E, et al. Biological, biochemical and histopathological features related to parasitic castration of Biomphalaria glabrata infected by Schistosoma mansoni. Exp Parasitol. 2013;134:228-34 pubmed publisher
    ..This study was designed to observe the parasitic castration of Biomphalaria glabrata infected with Schistosoma mansoni during both the pre-patent and patent periods...
  53. Kinkel H, Dittrich S, Bäumer B, Weitzel T. Evaluation of eight serological tests for diagnosis of imported schistosomiasis. Clin Vaccine Immunol. 2012;19:948-53 pubmed publisher
    ..The sensitivity values for detection of schistosomiasis cases ranged from 41% to 78% and were higher for Schistosoma mansoni than for S. haematobium infections...
  54. Dufour V, Beech R, Wever C, Dent J, Geary T. Molecular cloning and characterization of novel glutamate-gated chloride channel subunits from Schistosoma mansoni. PLoS Pathog. 2013;9:e1003586 pubmed publisher
    ..In this study, we characterized the anion-selective, non-acetylcholine-gated Cys-loop LGICs from Schistosoma mansoni. Full-length cDNAs were obtained for SmGluCl-1 (Smp_096480), SmGluCl-2 (Smp_015630) and SmGluCl-3 (..
  55. Adriko M, Standley C, Tinkitina B, Mwesigwa G, Kristensen T, Stothard J, et al. Compatibility of Ugandan Schistosoma mansoni isolates with Biomphalaria snail species from Lake Albert and Lake Victoria. Acta Trop. 2013;128:303-8 pubmed publisher
    In order to investigate the capacity of being intermediate host for Schistosoma mansoni, the Ugandan F1 generation of Biomphalaria snail species that were laboratory-bred from parent populations originally collected from either Lake ..
  56. El Beshbishi S, Taman A, El Malky M, Azab M, El Hawary A, El Tantawy D. First insight into the effect of single oral dose therapy with artemisinin-naphthoquine phosphate combination in a mouse model of Schistosoma mansoni infection. Int J Parasitol. 2013;43:521-30 pubmed publisher
    ..protocols were evaluated in experimentally infected mice harbouring juvenile or adult stages of Schistosoma mansoni (Egyptian strain)...
  57. Valentim C, Cioli D, Chevalier F, Cao X, Taylor A, Holloway S, et al. Genetic and molecular basis of drug resistance and species-specific drug action in schistosome parasites. Science. 2013;342:1385-9 pubmed publisher
    Oxamniquine resistance evolved in the human blood fluke (Schistosoma mansoni) in Brazil in the 1970s...
  58. Zeraik A, Pereira H, Santos Y, Brand o Neto J, Spoerner M, Santos M, et al. Crystal structure of a Schistosoma mansoni septin reveals the phenomenon of strand slippage in septins dependent on the nature of the bound nucleotide. J Biol Chem. 2014;289:7799-811 pubmed publisher
    ..Here, we present two crystal structures of the GTPase domain of a Schistosoma mansoni septin (SmSEPT10), one bound to GDP and the other to GTP...
  59. Raddatz G, Guzzardo P, Olova N, Fantappié M, Rampp M, Schaefer M, et al. Dnmt2-dependent methylomes lack defined DNA methylation patterns. Proc Natl Acad Sci U S A. 2013;110:8627-31 pubmed publisher
    ..Our results show that the genomes of Schistosoma mansoni and Drosophila melanogaster lack detectable DNA methylation patterns...
  60. Ramalhete C, Magalhaes L, Rodrigues V, Mulhovo S, da Silva Filho A, Ferreira M. In vitro schistosomicidal activity of balsaminol F and karavilagenin C. Planta Med. 2012;78:1912-7 pubmed publisher
    ..6-10) of karavilagenin C (2), were evaluated for their potential schistosomicidal activity against Schistosoma mansoni adult worms...
  61. el Agamy D, Shebl A, Said S. Prevention and treatment of Schistosoma mansoni-induced liver fibrosis in mice. Inflammopharmacology. 2011;19:307-16 pubmed publisher
    ..and curative effects of curcumin, resveratrol, imatinib, rosiglitazone, losartan and bosentan (BOS) on Schistosoma mansoni-induced liver fibrosis in mice...
  62. Nacif Pimenta R, de Mattos A, Orfanó A, Barbosa L, Pimenta P, Coelho P. Schistosoma mansoni in susceptible and resistant snail strains Biomphalaria tenagophila: in vivo tissue response and in vitro hemocyte interactions. PLoS ONE. 2012;7:e45637 pubmed publisher
    ..Biomphalaria tenagophila is an important invertebrate host of Schistosoma mansoni in Brazil, with some strains (e.g. Cabo Frio) being highly susceptible to the parasite, whereas others (e.g...
  63. Gower C, Gouvras A, Lamberton P, Deol A, Shrivastava J, Mutombo P, et al. Population genetic structure of Schistosoma mansoni and Schistosoma haematobium from across six sub-Saharan African countries: implications for epidemiology, evolution and control. Acta Trop. 2013;128:261-74 pubmed publisher
    ..the first meta-analysis of ten Schistosoma haematobium (one published and nine unpublished) and eight Schistosoma mansoni (two published and six unpublished) microsatellite datasets collected from individual schistosome-infected ..
  64. Meurs L, Mbow M, Vereecken K, Menten J, Mboup S, Polman K. Bladder morbidity and hepatic fibrosis in mixed Schistosoma haematobium and S. mansoni Infections: a population-wide study in Northern Senegal. PLoS Negl Trop Dis. 2012;6:e1829 pubmed publisher
    ..Here, we investigated the relationship between mixed Schistosoma infections and morbidity in the same population. So far, this has only been studied in children...
  65. Ingram J, Knudsen G, Lim K, Hansell E, Sakanari J, McKerrow J. Proteomic analysis of human skin treated with larval schistosome peptidases reveals distinct invasion strategies among species of blood flukes. PLoS Negl Trop Dis. 2011;5:e1337 pubmed publisher
    ..activity against insoluble elastin appears to be essential for this process in one species of schistosomes, Schistosoma mansoni, it is unknown whether other schistosome species use the same peptidase to facilitate entry into their hosts...
  66. Hodges M, Paye J, Koroma M, Nyorkor E, Fofonah I, Zhang Y. High level of Schistosoma mansoni infection in pre-school children in Sierra Leone highlights the need in targeting this age group for praziquantel treatment. Acta Trop. 2012;124:120-5 pubmed publisher
    ..The national control program currently does not target this group of children for schistosomiasis, while mass drug administration (MDA) has been performed six monthly for STHs in children 12-59 months of age since 2006...
  67. Anderson L, Pierce R, Verjovski Almeida S. Schistosoma mansoni histones: from transcription to chromatin regulation; an in silico analysis. Mol Biochem Parasitol. 2012;183:105-14 pubmed publisher
    b>Schistosoma mansoni is a human endoparasite with a complex life cycle that also infects an invertebrate mollusk intermediate host and exhibits many diverse phenotypes...
  68. Cupit P, Steinauer M, Tonnessen B, Eric Agola L, Kinuthia J, Mwangi I, et al. Polymorphism associated with the Schistosoma mansoni tetraspanin-2 gene. Int J Parasitol. 2011;41:1249-52 pubmed publisher
    ..Towards this end, inoculation with the large extracellular loop (EC-2) of Schistosoma mansoni tetraspanin-2 protein (Sm-TSP-2) has proved effective in reducing worm and egg burdens in S...
  69. Garba A, Lamine M, Djibo A, Tahirou A, Aouami M, Alfari A, et al. Safety and efficacy of praziquantel syrup (Epiquantel®) against Schistosoma haematobium and Schistosoma mansoni in preschool-aged children in Niger. Acta Trop. 2013;128:318-25 pubmed publisher
    ..9% (95% CI 90.5-97.6%), respectively. Considerably lower cure and egg reduction rates were observed against Schistosoma mansoni (e.g. cure rate at 6-week post-treatment follow-up was only 50.6% (95% CI 39.9-61.2%)...
  70. Bafica A, Cardoso L, Oliveira S, Loukas A, Varela G, Oliveira R, et al. Schistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis. Mem Inst Oswaldo Cruz. 2011;106:856-63 pubmed
    b>Schistosoma mansoni infection or associated products are able to down-modulate the type 1 CD4+ T cell inflammatory response characteristic of autoimmune diseases. In this study, we evaluated how S...
  71. Marco A, Kozomara A, Hui J, Emery A, Rollinson D, Griffiths Jones S, et al. Sex-biased expression of microRNAs in Schistosoma mansoni. PLoS Negl Trop Dis. 2013;7:e2402 pubmed publisher
    ..Here we characterize 112 microRNAs from adult Schistosoma mansoni individuals, including 84 novel microRNA families, and investigate the expression pattern in different ..
  72. Rinaldi G, Suttiprapa S, Tort J, Folley A, Skinner D, Brindley P. An antibiotic selection marker for schistosome transgenesis. Int J Parasitol. 2012;42:123-30 pubmed publisher
    ..concentrations were established: 125-1,000?g/ml G418 were progressively more toxic for schistosomules of Schistosoma mansoni with toxicity increasing with antibiotic concentration and with duration of exposure...
  73. Milligan J, Jolly E. Identification and characterization of a Mef2 transcriptional activator in schistosome parasites. PLoS Negl Trop Dis. 2012;6:e1443 pubmed publisher
    ..Here, we identify and characterize Mef2 from the schistosome worm Schistosoma mansoni (SmMef2)...
  74. Said E, Said S, Elkashef W, Gameil N, Ammar E. Tranilast ameliorates impaired hepatic functions in Schistosoma mansoni-infected mice. Inflammopharmacology. 2012;20:77-87 pubmed publisher
    ..cell stabilizer and anti-transforming growth factor(?) (TGF(?)) to improve impaired hepatic functions in Schistosoma mansoni (S...
  75. Peine M, Rausch S, Helmstetter C, Fröhlich A, Hegazy A, Kuhl A, et al. Stable T-bet(+)GATA-3(+) Th1/Th2 hybrid cells arise in vivo, can develop directly from naive precursors, and limit immunopathologic inflammation. PLoS Biol. 2013;11:e1001633 pubmed publisher
    ..Thus, we propose the self-limitation of effector T cells based on the stable cell-intrinsic balance of two opposing differentiation programs as a novel concept of how the immune system can prevent excessive inflammation. ..
  76. Miranda M, Magalhães L, Tiossi R, Kuehn C, Oliveira L, Rodrigues V, et al. Evaluation of the schistosomicidal activity of the steroidal alkaloids from Solanum lycocarpum fruits. Parasitol Res. 2012;111:257-62 pubmed publisher
    ..lycocarpum fruits and its isolated steroidal alkaloids were undertaken against adult worms of Schistosoma mansoni. The alkaloidic extract (20, 32, and 50 ?g mL(-1)), solasonine (50 ?M), solamargine (32 and 50 ?M), and ..
  77. Veras L, Guimaraes M, Campelo Y, Vieira M, Nascimento C, Lima D, et al. Activity of epiisopiloturine against Schistosoma mansoni. Curr Med Chem. 2012;19:2051-8 pubmed
    ..Here, we report the in vitro effect of this drug on the survival time of Schistosoma mansoni of different ages, such as 3 h old and 1, 3, 5, and 7 days old schistosomula, 49-day-old adults, and on egg ..
  78. Mouahid G, Idris M, Verneau O, Theron A, Shaban M, Moné H. A new chronotype of Schistosoma mansoni: adaptive significance. Trop Med Int Health. 2012;17:727-32 pubmed publisher
    ..b>Schistosoma mansoni has a strictly diurnal shedding pattern involving two circadian chronotypes: an early shedding pattern with ..
  79. Grant A, Araujo M, Ponte E, Oliveira R, Gao P, Cruz A, et al. Functional polymorphisms in IL13 are protective against high Schistosoma mansoni infection intensity in a Brazilian population. PLoS ONE. 2012;7:e35863 pubmed publisher
    ..IL-13 is a signature cytokine of the helper T cell type 2 (TH2) pathway which underlies host defense to helminthic infection and activates production of IgE in both parasitized populations and in urban settings after allergen exposure...
  80. Gryseels B. Schistosomiasis. Infect Dis Clin North Am. 2012;26:383-97 pubmed publisher
    ..Praziquantel is the drug of choice, active against all species in a single or a few oral doses. Current control strategies consist mainly of preventive therapy in communities or groups at risk...
  81. Caldeira K, Teixeira C, Silveira M, Fries L, Romanzini J, Bittencourt H, et al. Comparison of the Kato-Katz and Helmintex methods for the diagnosis of schistosomiasis in a low-intensity transmission focus in Bandeirantes, Paraná, southern Brazil. Mem Inst Oswaldo Cruz. 2012;107:690-2 pubmed
    ..The results confirm the previously demonstrated higher sensitivity of the Helmintex method compared with the KK method...
  82. Butler S, Muok E, Montgomery S, Odhiambo K, Mwinzi P, Secor W, et al. Mechanism of anemia in Schistosoma mansoni-infected school children in Western Kenya. Am J Trop Med Hyg. 2012;87:862-7 pubmed publisher
    A better understanding of the mechanism of anemia associated with Schistosoma mansoni infection might provide useful information on how treatment programs are implemented to minimize schistosomiasis-associated morbidity and maximize ..
  83. de Moraes J, Keiser J, Ingram K, Nascimento C, Yamaguchi L, Bittencourt C, et al. In vitro synergistic interaction between amide piplartine and antimicrobial peptide dermaseptin against Schistosoma mansoni schistosomula and adult worms. Curr Med Chem. 2013;20:301-9 pubmed
    ..amide piplartine and the antimicrobial peptide dermaseptin 01 administered singly or in combination against Schistosoma mansoni of different ages including 3-hour-old and 7-day-old schistosomula and 49-day-old adult schistosomes as ..
  84. Levitz S, Standley C, Adriko M, Kabatereine N, Stothard J. Environmental epidemiology of intestinal schistosomiasis and genetic diversity of Schistosoma mansoni infections in snails at Bugoigo village, Lake Albert. Acta Trop. 2013;128:284-91 pubmed publisher
    ..factors that determine the local distribution and abundance of Biomphalaria, as well as infection(s) with Schistosoma mansoni inclusive of their genetic diversity...