schistosoma japonicum

Summary

Summary: A species of trematode blood flukes belonging to the family Schistosomatidae whose distribution is confined to areas of the Far East. The intermediate host is a snail. It occurs in man and other mammals.

Top Publications

  1. Wang J, Yu C, Yin X, Zhang W, Qian C, Song L, et al. Monitoring specific antibody responses against the hydrophilic domain of the 23 kDa membrane protein of Schistosoma japonicum for early detection of infection in sentinel mice. Parasit Vectors. 2011;4:172 pubmed publisher
  2. Carlton E, Bates M, Zhong B, Seto E, Spear R. Evaluation of mammalian and intermediate host surveillance methods for detecting schistosomiasis reemergence in southwest China. PLoS Negl Trop Dis. 2011;5:e987 pubmed publisher
    ..Schistosomiasis has reemerged in China, threatening schistosomiasis elimination efforts. Surveillance methods that can identify locations where schistosomiasis has reemerged are needed to prevent the further spread of infections...
  3. Zeng H, Yang X, Meng S, Wang H, Tang X, Tang W, et al. Awareness and knowledge of schistosomiasis infection and prevention in the "Three Gorges Dam" reservoir area: a cross-sectional study on local residents and health personnel. Acta Trop. 2011;120:238-44 pubmed publisher
    ..Although there were multiple risks for potential Schistosoma japonicum infections in the study area, the knowledge level on schistosomiasis and surveillance was relatively low ..
  4. Remais J, Zhong B, Carlton E, Spear R. Model approaches for estimating the influence of time-varying socio-environmental factors on macroparasite transmission in two endemic regions. Epidemics. 2009;1:213-20 pubmed publisher
    ..The importance of these factors for control programs and surveillance is discussed. ..
  5. Su J, Zhou F, Lu D. A circular analysis of chronobiology of Schistosoma japonicum cercarial emergence from hilly areas of Anhui, China. Exp Parasitol. 2013;135:421-5 pubmed publisher
    About 46 mammal species have been suspected as reservoir hosts for Schistosoma japonicum and therefore the track of the target parasites, in relation to definitive host species, may be of great importance in terms of theoretical and ..
  6. Chen L, Liu W, Lei J, Guan F, Li M, Song W, et al. Chronic Schistosoma japonicum infection reduces immune response to vaccine against hepatitis B in mice. PLoS ONE. 2012;7:e51512 pubmed publisher
    ..In this paper, we demonstrate in a mouse model that a chronic Schistosoma japonicum infection can inhibit the immune response to hepatitis B vaccine (HBV vaccine) and lead to lower ..
  7. Zhang M, Hong Y, Han Y, Han H, Peng J, Qiu C, et al. Proteomic analysis of tegument-exposed proteins of female and male Schistosoma japonicum worms. J Proteome Res. 2013;12:5260-70 pubmed publisher
    ..combined with LC-MS/MS was used to analyze putative tegument-exposed proteins in female and male adult Schistosoma japonicum worms...
  8. Zhao F, Huang X, Hou X, Deng Y, Wu M, Guan F, et al. Schistosoma japonicum: susceptibility of neonate mice born to infected and noninfected mothers following subsequent challenge. Parasite Immunol. 2013;35:157-63 pubmed publisher
    This study was to investigate the differences between neonate mice born to Schistosoma japonicum-infected mothers and those born to noninfected mothers in subsequent challenge...
  9. Kumagai T, Furushima Shimogawara R, Ohmae H, Wang T, Lu S, Chen R, et al. Detection of early and single infections of Schistosoma japonicum in the intermediate host snail, Oncomelania hupensis, by PCR and loop-mediated isothermal amplification (LAMP) assay. Am J Trop Med Hyg. 2010;83:542-8 pubmed publisher
    Polymerase chain reaction (PCR) with the specific primer set amplifying 28S ribosomal DNA (rDNA) of Schistosoma japonicum was able to detect genomic DNA of S. japonicum, but not S. mansoni, at 100 fg...

More Information

Publications92

  1. Jiang Y, Xu X, Qing X, Pan W. Identification and characterization of six novel tetraspanins from Schistosoma japonicum. Parasit Vectors. 2011;4:190 pubmed publisher
    ..In the work presented here, six novel TSP proteins from the human blood fluke Schistosoma japonicum (S...
  2. Burke M, McGarvey L, McSorley H, Bielefeldt Ohmann H, McManus D, Gobert G. Migrating Schistosoma japonicum schistosomula induce an innate immune response and wound healing in the murine lung. Mol Immunol. 2011;49:191-200 pubmed publisher
    ..initiate a primary host immune response we have characterised the host lung response to migrating Schistosoma japonicum schistosomula using a combination of histopathology, microarray analysis and real-time PCR...
  3. Zhang M, Han Y, Zhu Z, Li D, Hong Y, Wu X, et al. Cloning, expression, and characterization of Schistosoma japonicum tegument protein phosphodiesterase-5. Parasitol Res. 2012;110:775-86 pubmed publisher
    ..In the present study, SjNPP-5, identified as one of the tegument proteins of Schistosoma japonicum in our previous proteomic studies, was cloned on a fragment of 1,371 bp and expressed as a recombinant ..
  4. Liu J, Hu W, Xu B, Wang J, Wang S, Wang X. [Schistosomicidal mechanism of auranofin on Schistosoma japonicum and its cytotoxicity]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2012;30:450-4 pubmed
    To compare the effect and acted target of auranofin on juvenile and adult Schistosoma japonicum, and detect the cytotoxicity of auranofin against host cells...
  5. Zhang M, Gao Y, Du X, Zhang D, Ji M, Wu G. Toll-like receptor (TLR) 2 and TLR4 deficiencies exert differential in vivo effects against Schistosoma japonicum. Parasite Immunol. 2011;33:199-209 pubmed publisher
    Little is known about the functions of Toll-like receptor 2 (TLR2) and TLR4 in innate/acquired responses to Schistosoma japonicum. Through in vivo study, the contributions of TLR2 and TLR4 to host immune responses during S...
  6. Chuah C, Jones M, Burke M, Owen H, Anthony B, McManus D, et al. Spatial and temporal transcriptomics of Schistosoma japonicum-induced hepatic granuloma formation reveals novel roles for neutrophils. J Leukoc Biol. 2013;94:353-65 pubmed publisher
    ..zones within, and directly proximal to, hepatic granulomas that developed in C57BL/6 mice infected with Schistosoma japonicum. There was significant up-regulation of type-1, type-2, and type-17 immune-associated genes within the ..
  7. Shaw J, Aggarwal N, Acosta L, Jiz M, Wu H, Leenstra T, et al. Reduction in hookworm infection after praziquantel treatment among children and young adults in Leyte, the Philippines. Am J Trop Med Hyg. 2010;83:416-21 pubmed publisher
    ..and every 3 months for 18 months, three stool samples were collected, and the intensity of infection with Schistosoma japonicum and soil-transmitted helminths (STHs) was quantified...
  8. Wei F, Zhai Y, Jin H, Shang L, Men J, Lin J, et al. Development and immunogenicity of a recombinant pseudorabies virus expressing Sj26GST and SjFABP from Schistosoma japonicum. Vaccine. 2010;28:5161-6 pubmed publisher
    Recombinant pseudorabies virus (PRV) Bartha-K61 vaccine strains expressing Schistosoma japonicum 26kDa glutathione S-transferase (Sj26GST) and fatty acid binding protein (SjFABP), designated as rPRV/Sj26GST, rPRV/SjFABP and rPRV/Sj26GST-..
  9. Lu D, Rudge J, Wang T, Donnelly C, Fang G, Webster J. Transmission of Schistosoma japonicum in marshland and hilly regions of China: parasite population genetic and sibship structure. PLoS Negl Trop Dis. 2010;4:e781 pubmed publisher
    The transmission dynamics of Schistosoma japonicum remain poorly understood, as over forty species of mammals are suspected of serving as reservoir hosts...
  10. Spear R. Internal versus external determinants of Schistosoma japonicum transmission in irrigated agricultural villages. J R Soc Interface. 2012;9:272-82 pubmed publisher
    ..This need is underscored by the high cost and limited sensitivity of current methods for diagnosing human infection and mounting evidence of the inadequacy of snail surveys to identify environments supporting low levels of transmission. ..
  11. You H, Gobert G, Duke M, Zhang W, Li Y, Jones M, et al. The insulin receptor is a transmission blocking veterinary vaccine target for zoonotic Schistosoma japonicum. Int J Parasitol. 2012;42:801-7 pubmed publisher
    Insulin receptors have been previously identified in Schistosoma japonicum that can bind human insulin. We used the purified recombined protein of the ligand domain of S...
  12. Yang J, Qiu C, Xia Y, Yao L, Fu Z, Yuan C, et al. Molecular cloning and functional characterization of Schistosoma japonicum enolase which is highly expressed at the schistosomulum stage. Parasitol Res. 2010;107:667-77 pubmed publisher
    ..In the present study, the enolase of Schistosoma japonicum has been cloned and expressed. In western blot analysis, the recombinant enolase from S...
  13. Mbanefo E, Chuanxin Y, Kikuchi M, Shuaibu M, Boamah D, Kirinoki M, et al. Origin of a novel protein-coding gene family with similar signal sequence in Schistosoma japonicum. BMC Genomics. 2012;13:260 pubmed publisher
    ..Recently, we identified six protein-coding genes with similar signal sequence from Schistosoma japonicum egg stage mRNA using signal sequence trap (SST)...
  14. Thanchomnang T, Intapan P, Sri aroon P, Lulitanond V, Janwan P, Sanpool O, et al. Molecular detection of Schistosoma japonicum in infected snails and mouse faeces using a real-time PCR assay with FRET hybridisation probes. Mem Inst Oswaldo Cruz. 2011;106:831-6 pubmed
    ..energy transfer (FRET) hybridisation probes combined with melting curve analysis was developed to detect Schistosoma japonicum in experimentally infected snails and in faecal samples of infected mice...
  15. Burke M, McManus D, Ramm G, Duke M, Li Y, Jones M, et al. Co-ordinated gene expression in the liver and spleen during Schistosoma japonicum infection regulates cell migration. PLoS Negl Trop Dis. 2010;4:e686 pubmed publisher
    ..defines the transcriptional and cellular events occurring in the murine spleen during the progression of Schistosoma japonicum infection...
  16. Song L, Li J, Xie S, Qian C, Wang J, Zhang W, et al. Thioredoxin glutathione reductase as a novel drug target: evidence from Schistosoma japonicum. PLoS ONE. 2012;7:e31456 pubmed publisher
    ..existense and the potential value of TGR as a target for development of novel antischistosomal agents in Schistosoma japonicum, a platyhelminth endemic in Asia. After cloning the S...
  17. Wan C, Liu Y, Tu X, Zhang Y, Xu J, Lin D, et al. A cellular automaton model of Schistosoma japonicum infection. Acta Trop. 2013;126:256-64 pubmed publisher
    Due to the life cycle complexity of Schistosoma japonicum and the characteristics of schistosomias is immuno-epidemiology, it is very challenging to give a group of certain rules and thus describe the transmission dynamics of S...
  18. Wu C, Cai P, Chang Q, Hao L, Peng S, Sun X, et al. Mapping the binding between the tetraspanin molecule (Sjc23) of Schistosoma japonicum and human non-immune IgG. PLoS ONE. 2011;6:e19112 pubmed publisher
    ..Sjc23, a member of the tetraspanin (TSP) family of Schistosoma japonicum, was previously found to be highly immunogenic and regarded as a vaccine candidate against schistosomiasis...
  19. Ezeamama A, McGarvey S, Hogan J, Lapane K, Bellinger D, Acosta L, et al. Treatment for Schistosoma japonicum, reduction of intestinal parasite load, and cognitive test score improvements in school-aged children. PLoS Negl Trop Dis. 2012;6:e1634 pubmed publisher
    ..children, we examined changes in cognitive testscores over 18 months in relation to: (i) treatment-related Schistosoma japonicum intensity decline, (ii) spontaneous reduction of single soil-transmitted helminth (STH) species, and (iii) ..
  20. Liu J, Yu H, Shi Y, Li H, He L, Li J, et al. Seasonal dynamics of Schistosoma japonicum infection in buffaloes in the Poyang Lake region and suggestions on local treatment schemes. Vet Parasitol. 2013;198:219-22 pubmed publisher
    ..Buffaloes play a major role in the transmission of Schistosoma japonicum to humans...
  21. Liu J, Zhu C, Shi Y, Li H, Wang L, Qin S, et al. Surveillance of Schistosoma japonicum infection in domestic ruminants in the Dongting Lake region, Hunan province, China. PLoS ONE. 2012;7:e31876 pubmed publisher
    ..Domestic ruminants, especially bovines, have long been considered to play a major role in the transmission of Schistosoma japonicum to humans.
  22. Yang Y, Jin Y, Liu P, Shi Y, Cao Y, Liu J, et al. RNAi silencing of type V collagen in Schistosoma japonicum affects parasite morphology, spawning, and hatching. Parasitol Res. 2012;111:1251-7 pubmed publisher
    ..si) RNAs targeting different regions of the gene were designed to suppress the expression of SjColV in Schistosoma japonicum using a soaking method...
  23. Yang J, Yang L, Lv Z, Wang J, Zhang Q, Zheng H, et al. Molecular cloning and characterization of a HSP70 gene from Schistosoma japonicum. Parasitol Res. 2012;110:1785-93 pubmed publisher
    b>Schistosoma japonicum is the pathogen responsible for schistosomiasis japonica, one of the major infectious diseases targeted for prevention nationally in China...
  24. Han H, Peng J, Gobert G, Hong Y, Zhang M, Han Y, et al. Apoptosis phenomenon in the schistosomulum and adult worm life cycle stages of Schistosoma japonicum. Parasitol Int. 2013;62:100-8 pubmed publisher
    ..7 activities in schistosome demonstrated that both caspases were active in each developmental stage of Schistosoma japonicum, but was highest in the 14 days post infection schistosomula...
  25. Yang F, Sun X, Shen J, Yu L, Liang J, Zheng H, et al. A recombined protein (rSj16) derived from Schistosoma japonicum induces cell cycle arrest and apoptosis of murine myeloid leukemia cells. Parasitol Res. 2013;112:1261-72 pubmed publisher
    rSj16, a recombined protein from Schistosoma japonicum, has been identified as an anti-inflammatory molecule...
  26. Wang M, Cao Y, Luo E, Zhang Y, Guo Y. Pre-existing Schistosoma japonicum infection alters the immune response to Plasmodium berghei infection in C57BL/6 mice. Malar J. 2013;12:322 pubmed publisher
    ..In the current study, distinct response profiles for splenic DCs and regulatory T cell (Treg) responses were assessed to evaluate the effects of a pre-existing Schistosoma japonicum infection on malaria infection.
  27. Xu J, Ren Y, Xu X, Chen J, Li Y, Gan W, et al. Schistosoma japonicum tegumental protein 20.8, role in reproduction through its calcium binding ability. Parasitol Res. 2014;113:491-7 pubmed publisher
    Schistosomiasis threatens thousands of millions of peoples' health every year in the world. Schistosoma japonicum, a pathogen of schistosomiasis, is covered by a lipid bilayer membrane which plays an important role in nutrient transport, ..
  28. Worrell C, Xiao N, Vidal J, Chen L, Zhong B, Remais J. Field detection of Schistosoma japonicum cercariae in environmental water samples by quantitative PCR. Appl Environ Microbiol. 2011;77:2192-5 pubmed publisher
    ..japonicum in surface waters. The novel methods were capable of capturing cercariae and, with subsequent analysis through qPCR, detecting the presence of a minimum of 1 cercaria...
  29. Xiao S, Zhang C. Further observation on histopathological alterations of adult Schistosoma japonicum harbored in mice following treatment with mefloquine at a smaller single dose. Parasitol Res. 2010;107:773-81 pubmed publisher
    ..Mice were infected with Schistosoma japonicum cercariae for 35 days and then treated with a single 200 mg/kg oral dose of mefloquine...
  30. He Y, Li J, Zhuang W, Yin L, Chen C, Li J, et al. The inhibitory effect against collagen-induced arthritis by Schistosoma japonicum infection is infection stage-dependent. BMC Immunol. 2010;11:28 pubmed publisher
    ..The present study was designed to study whether different stages of schistosome infection offer unique protection in collagen-induced arthritis and its mechanisms...
  31. Li J, Zhuang W, Cong L, Shi W, Cai X, Huang F, et al. Cyclophilin A from Schistosoma japonicum promotes a Th2 response in mice. Parasit Vectors. 2013;6:330 pubmed publisher
    ..A cyclophilin A homologue of Schistosoma japonicum was reported to be an egg-stage specific antigen, but its immunogenicity and immunoregulatory activities ..
  32. Guo F, Wang Y, Li Y, Peng J, Hong Y, Qiu C, et al. [Evaluation on the immuno-protective efficacy of the recombinant antigen SjPGAM-SjEnol against Schistosoma japonicum in mice]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2010;28:246-51 pubmed
    To construct and express the recombinant plasmid pET32a-SjPGAM-SjEnol and evaluate its immuno-protective efficacy against the infection of Schistosoma japonicum in mice.
  33. Wang X, Liu F, Zhou S, Xu Z, Hoellwarth J, Chen X, et al. Partial regulatory T cell depletion prior to schistosomiasis vaccination does not enhance the protection. PLoS ONE. 2012;7:e40359 pubmed publisher
    ..In this study, a DNA vaccine encoding a 26 kDa glutathione S-transferase of Schistosoma japonicum (pVAX1-Sj26GST) was constructed and its potential effects were evaluated by depleting CD25(+) cells prior ..
  34. Sun X, Liu Y, Lv Z, Yang L, Hu S, Zheng H, et al. rSj16, a recombinant protein of Schistosoma japonicum-derived molecule, reduces severity of the complete Freund's adjuvant-induced adjuvant arthritis in rats' model. Parasite Immunol. 2010;32:739-48 pubmed publisher
    Sj16, a 16-kDa protein produced by Schistosoma japonicum, has been demonstrated to have anti-inflammatory effect. However, the possible mechanism of these phenomena has not been discovered...
  35. Feng Y, Liu L, Wang J, Liu J, Hu W, Wang X, et al. Integrated refolding techniques for Schistosoma japonicum MTH1 overexpressed as inclusion bodies in Escherichia coli. Protein Expr Purif. 2012;84:181-7 pubmed publisher
    The full-length cDNA of MTH1in Schistosoma japonicum was previously isolated. However, insoluble protein expression in Escherichia coli is the biggest bottleneck limiting biological and biophysical studies...
  36. Tian F, Lin D, Wu J, Gao Y, Zhang D, Ji M, et al. Immune events associated with high level protection against Schistosoma japonicum infection in pigs immunized with UV-attenuated cercariae. PLoS ONE. 2010;5:e13408 pubmed publisher
    The vaccination of radiation-attenuated Schistosoma japonicum cercariae can induce effective protection in artiodactyl, but the immune events related to protective immunity are not fully understood...
  37. Han H, Peng J, Hong Y, Fu Z, Xu J, Lin J, et al. Molecular cloning and characterization of a cyclophilin A homologue from Schistosoma japonicum. Parasitol Res. 2012;111:807-17 pubmed publisher
    ..The SjCyPA protein was located on the subtegumental musculature of Schistosoma japonicum as determined by immunohistochemical staining analysis...
  38. Carlton E, Hubbard A, Wang S, Spear R. Repeated Schistosoma japonicum infection following treatment in two cohorts: evidence for host susceptibility to helminthiasis?. PLoS Negl Trop Dis. 2013;7:e2098 pubmed publisher
    ..Such individuals are not only at risk of morbidity, but may be important parasite reservoirs and appropriate targets for disease control interventions...
  39. Yuan C, Fu Y, Li J, Yue Y, Cai L, Xiao W, et al. Schistosoma japonicum: efficient and rapid purification of the tetraspanin extracellular loop 2, a potential protective antigen against schistosomiasis in mammalian. Exp Parasitol. 2010;126:456-61 pubmed publisher
    The extracellular loop 2 of a tetraspanin from Schistosoma japonicum (Sj-TSP-2) is homologous to Schistosoma mansoni TSP-2. In our initial study, Sj-TSP-2 is an identical antigen against schistosomiasis caused by S. japonicum...
  40. Chen J, Yang Y, Guo S, Peng J, Liu Z, Li J, et al. Molecular cloning and expression profiles of Argonaute proteins in Schistosoma japonicum. Parasitol Res. 2010;107:889-99 pubmed publisher
    ..In the present study, we systematically investigated Argonaute proteins in Schistosoma japonicum by using bioinformatics in combination with 5'- and 3'-Rapid Amplification of cDNA ends techniques and ..
  41. Chen Q, Guan F, Yan D, Lei D, Fu L, Xia H, et al. The dynamic expression of allograft inflammatory factor-1 in hepatic tissues and splenic cells of BALB/c mice with Schistosoma japonicum infection. Tissue Antigens. 2012;79:33-41 pubmed publisher
    ..japonicum, and the interaction between AIF-1 and TNF-? or other cytokines played an important role in the pathogenesis and progression of hepatic schistosomiasis...
  42. Angeles J, Goto Y, Kirinoki M, Leonardo L, Tongol Rivera P, Villacorte E, et al. Human antibody response to thioredoxin peroxidase-1 and tandem repeat proteins as immunodiagnostic antigen candidates for Schistosoma japonicum infection. Am J Trop Med Hyg. 2011;85:674-9 pubmed publisher
    ..These results suggest the potential defined antigens for development of an accurate diagnostic test for schistosomiasis...
  43. Wen X, He L, Chi Y, Zhou S, Hoellwarth J, Zhang C, et al. Dynamics of Th17 cells and their role in Schistosoma japonicum infection in C57BL/6 mice. PLoS Negl Trop Dis. 2011;5:e1399 pubmed publisher
    ..in vivo data are available on the dynamics of Th17 cells, another important CD4(+) T cell subset, after Schistosoma japonicum infection or whether these cells and their defining IL-17 cytokine mediate host protective responses early ..
  44. Xiao H, Wei H, Yang G, Peng H, Zhang C. [Effects of paeoniflorin on expressions of CTGF, PDGF and TNF-alpha in mice with hepatic fibrosis due to Schistosoma japonicum infection]. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2011;23:288-91 pubmed
    ..on the expressions of CTGF and PDGF in liver tissue of fibrosis and the serum level of TNF-alpha in mice infected with Schistosoma japonicum, and to explore the protective effect and its mechanisms of paeoniflorin on liver fibrosis.
  45. Fabre V, Wu H, Pondtor S, Coutinho H, Acosta L, Jiz M, et al. Tissue inhibitor of matrix-metalloprotease-1 predicts risk of hepatic fibrosis in human Schistosoma japonicum infection. J Infect Dis. 2011;203:707-14 pubmed publisher
    ..Little is known regarding the mechanisms of schistosome-associated hepatic fibrosis in humans, and few biomarkers for risk of fibrosis have been identified...
  46. Xu J, Peeling R, Chen J, Wu X, Wu Z, Wang S, et al. Evaluation of immunoassays for the diagnosis of Schistosoma japonicum infection using archived sera. PLoS Negl Trop Dis. 2011;5:e949 pubmed publisher
    With a national program initiated recently to reduce transmission of Schistosoma japonicum in the People's Republic of China (P.R...
  47. Luo R, Zhou C, Lin J, Yang D, Shi Y, Cheng G. Identification of in vivo protein phosphorylation sites in human pathogen Schistosoma japonicum by a phosphoproteomic approach. J Proteomics. 2012;75:868-77 pubmed publisher
    ..vivo protein phosphorylation events in different developmental stages (schistosomula and adult worms) of Schistosoma japonicum by using microvolume immobilized metal-ion affinity chromatography (IMAC) pipette tips coupled to nanoLC-..
  48. Cao Y, Shi Y, Qiao H, Yang Y, Liu J, Shi Y, et al. Distribution of lethal giant larvae (Lgl) protein in the tegument and negative impact of siRNA-based gene silencing on worm surface structure and egg hatching in Schistosoma japonicum. Parasitol Res. 2014;113:1-9 pubmed publisher
    ..Here, we report the presence of Lgl gene in the blood fluke Schistosoma japonicum (SjLgl) (GenBank: KF246684)...
  49. Piao X, Cai P, Liu S, Hou N, Hao L, Yang F, et al. Global expression analysis revealed novel gender-specific gene expression features in the blood fluke parasite Schistosoma japonicum. PLoS ONE. 2011;6:e18267 pubmed publisher
    b>Schistosoma japonicum is one of the remarkable Platyhelminths that are endemic in China and Southeast Asian countries. The parasite is dioecious and can reside inside the host for many years...
  50. Zhou Y, Liang S, Chen G, Rea C, Han S, He Z, et al. Spatial-temporal variations of Schistosoma japonicum distribution after an integrated national control strategy: a cohort in a marshland area of China. BMC Public Health. 2013;13:297 pubmed publisher
    ..Schistosomiasis transmission is typically focal. Understanding spatial variations of Schistosoma infections and their associated factors is important to help to invent site-specific intervention strategies...
  51. Xu J, Feng T, Lin D, Wang Q, Tang L, Wu X, et al. Performance of a dipstick dye immunoassay for rapid screening of Schistosoma japonicum infection in areas of low endemicity. Parasit Vectors. 2011;4:87 pubmed publisher
    ..R. China), is a rapid and simple test to detect human antibodies against Schistosoma Japonicum. Its performance and utility for screening schistosome infection in low endemic areas is little known...
  52. Qian C, Huang B, Yu C, Zhang J, Yin X, Wang J, et al. Detection of the circulating antigen 14-3-3 protein of Schistosoma japonicum by time-resolved fluoroimmunoassay in rabbits. Parasit Vectors. 2011;4:95 pubmed publisher
    ..In this study, a time-resolved fluoroimmunoassay (TRFIA) was developed for detecting the signal transduction protein 14-3-3, a circulating antigen of Schistosoma japonicum.
  53. Cai P, Piao X, Hao L, Liu S, Hou N, Wang H, et al. A deep analysis of the small non-coding RNA population in Schistosoma japonicum eggs. PLoS ONE. 2013;8:e64003 pubmed publisher
    b>Schistosoma japonicum is a parasitic flatworm that causes zoonotic schistosomiasis. The typical outcome of schistosomiasis is hepatic granuloma and fibrosis, which is primarily induced by soluble egg-derived antigens...
  54. Li M, Lei J, Wang T, Lu S, Guan F, Liu W, et al. Cimetidine enhances the protective effect of GST DNA vaccine against Schistosoma japonicum. Exp Parasitol. 2011;128:427-32 pubmed publisher
    ..enhanced green fluorescent protein gene and the gene encoding 26 kDa glutathione S-transferase of Schistosoma japonicum) DNA vaccine to immunized mice and attempted to enhance the protective effect against S. japonicum...
  55. Li H, Wang X, Jin Y, Xia Y, Feng X, Yang J, et al. Wnt4, the first member of the Wnt family identified in Schistosoma japonicum, regulates worm development by the canonical pathway. Parasitol Res. 2010;107:795-805 pubmed publisher
    ..We therefore isolated the Wnt4 gene from Schistosoma japonicum. Wnt4 encodes a putative protein of 558 amino acids which contains the conserved functional domain of the ..
  56. McWilliam H, Piedrafita D, Li Y, Zheng M, He Y, Yu X, et al. Local immune responses of the Chinese water buffalo, Bubalus bubalis, against Schistosoma japonicum larvae: crucial insights for vaccine design. PLoS Negl Trop Dis. 2013;7:e2460 pubmed publisher
    ..This study offers a deeper understanding into the immunobiology of schistosomiasis in a natural host, which may aid in the future design of more effective vaccines. ..
  57. Yang K, Li W, Sun L, Huang Y, Zhang J, Wu F, et al. Spatio-temporal analysis to identify determinants of Oncomelania hupensis infection with Schistosoma japonicum in Jiangsu province, China. Parasit Vectors. 2013;6:138 pubmed publisher
  58. Tang H, Ming Z, Liu R, Xiong T, Grevelding C, Dong H, et al. Development of adult worms and granulomatous pathology are collectively regulated by T- and B-cells in mice infected with Schistosoma japonicum. PLoS ONE. 2013;8:e54432 pubmed publisher
    ..of B cells can more seriously hamper the development and paring of adult worms, but granuloma formation of Schistosoma japonicum in scid mice was not down-regulated comparing with that in nude mice...
  59. Wang W, Li H, Qu G, Xing Y, Yang Z, Dai J, et al. Is there a reduced sensitivity of dihydroartemisinin against praziquantel-resistant Schistosoma japonicum?. Parasitol Res. 2014;113:223-8 pubmed publisher
    ..However, it has been proved that Schistosoma japonicum subjected to drug pressure may develop resistance to praziquantel...
  60. McManus D, Gray D, Ross A, Williams G, He H, Li Y. Schistosomiasis research in the dongting lake region and its impact on local and national treatment and control in China. PLoS Negl Trop Dis. 2011;5:e1053 pubmed publisher
    ..This is not the case in the People's Republic of China (PRC), where the disease, caused by Schistosoma japonicum, has long captured the attention of the Chinese authorities who have, over the past 50-60 years, ..
  61. Chen G, Dai Y, Chen J, Wang X, Tang B, Zhu Y, et al. Oral delivery of the Sj23LHD-GST antigen by Salmonella typhimurium type III secretion system protects against Schistosoma japonicum infection in mice. PLoS Negl Trop Dis. 2011;5:e1313 pubmed publisher
    ..work used an attenuated Salmonella typhimurium strain VNP20009 to secretory expression of Sj23LHDGST bivalent antigen from Schistosoma japonicum and tested the protective efficacy against S. japonicum infection in orally immunized mice.
  62. Peng J, Gobert G, Hong Y, Jiang W, Han H, McManus D, et al. Apoptosis governs the elimination of Schistosoma japonicum from the non-permissive host Microtus fortis. PLoS ONE. 2011;6:e21109 pubmed publisher
    The reed vole, Microtus fortis, is the only known mammalian host in which schistosomes of Schistosoma japonicum are unable to mature and cause significant pathogenesis...
  63. Lin D, Tian F, Wu H, Gao Y, Wu J, Zhang D, et al. Multiple vaccinations with UV- attenuated cercariae in pig enhance protective immunity against Schistosoma japonicum infection as compared to single vaccination. Parasit Vectors. 2011;4:103 pubmed publisher
    ..To compare the efficacy of a single vaccination and multiple vaccinations with UV-attenuated Schistosoma japonicum cercariae, two groups of pigs received either one or three exposures to 10,000 cercariae attenuated with ..
  64. Sun L, Liang Y, Wu H, Tian Z, Dai J, Yang K, et al. A Google Earth-based surveillance system for schistosomiasis japonica implemented in the lower reaches of the Yangtze River, China. Parasit Vectors. 2011;4:223 pubmed publisher
    ..In this study, we imported Google Earth technology and a Global Positioning System (GPS) into the monitoring system for schistosomiasis surveillance of the banks of the Yangtze River in Jiangsu Province, China...
  65. Wang W, Li Y, Li H, Xing Y, Qu G, Dai J, et al. Immunodiagnostic efficacy of detection of Schistosoma japonicum human infections in China: a meta analysis. Asian Pac J Trop Med. 2012;5:15-23 pubmed publisher
    ..used indirect hemagglutination assay (IHA) and enzyme-linked immunosorbent assay (ELISA) for detection of Schistosoma japonicum human infections...
  66. Zhao G, Li J, Song H, Li X, Chen F, Lin R, et al. A specific PCR assay for the identification and differentiation of Schistosoma japonicum geographical isolates in mainland China based on analysis of mitochondrial genome sequences. Infect Genet Evol. 2012;12:1027-36 pubmed publisher
    In the present study, near-complete mt genome sequences for eight representative Schistosoma japonicum samples from seven endemic provinces in mainland China were analyzed. Sequence differences among the eight mt genomes of S...
  67. Sun L, Wang W, Liang Y, Tian Z, Hong Q, Yang K, et al. Effect of an integrated control strategy for schistosomiasis japonica in the lower reaches of the Yangtze River, China: an evaluation from 2005 to 2008. Parasit Vectors. 2011;4:243 pubmed publisher
    ..There are many interventions implemented to control the transmission of the disease. The purpose of the present study was to investigate the effects of an integrated control strategy for schistosomiasis control...
  68. Peng J, Han H, Gobert G, Hong Y, Jiang W, Wang X, et al. Differential gene expression in Schistosoma japonicum schistosomula from Wistar rats and BALB/c mice. Parasit Vectors. 2011;4:155 pubmed publisher
    More than 46 species of mammals can be naturally infected with Schistosoma japonicum in the mainland of China. Mice are permissive and may act as the definitive host of the life cycle. In contrast, rats are less susceptible to S...
  69. Liu R, Dong H, Jiang M. What is the role of health education in the integrated strategy to control transmission of Schistosoma japonicum in China?. Parasitol Res. 2012;110:2081-2 pubmed publisher
    ..reported that a comprehensive strategy aiming to reduce the roles of humans and cattle as sources of Schistosoma japonicum infection in snails was implemented and proved effective and promising in dramatically reducing the ..
  70. Wang S, Carlton E, Chen L, Liu Y, Spear R. Evaluation of an educational intervention on villagers' knowledge, attitude and behaviour regarding transmission of Schistosoma japonicum in Sichuan province, China. Acta Trop. 2013;127:226-35 pubmed publisher
    ..Considering the difficulties of occupation-associated behaviour change and knowledge reinforcement in general, longer-term education programmes should be considered in the future. ..
  71. Wang H, Zhao Q, Nie P, Jiang M, Song J. Identification of differentially expressed genes in Oncomelania hupensis chronically infected with Schistosoma japonicum. Exp Parasitol. 2012;130:374-83 pubmed publisher
    Oncomelania hupensis is the unique intermediate host of Schistosoma japonicum. The schistosome-snail interaction is biomedically important. To identify differentially expressed transcripts in O. hupensis chronically infected with S...
  72. Wang J, Zhao F, Yu C, Xiao D, Song L, Yin X, et al. Identification of proteins inducing short-lived antibody responses from excreted/secretory products of Schistosoma japonicum adult worms by immunoproteomic analysis. J Proteomics. 2013;87:53-67 pubmed publisher
    The excretory/secretory antigens of Schistosoma japonicum (Sj ESAgs) play important roles in host-parasite immune interactions...
  73. Han Y, Zhang M, Hong Y, Zhu Z, Li D, Li X, et al. Characterization of thioredoxin glutathione reductase in Schiotosoma japonicum. Parasitol Int. 2012;61:475-80 pubmed publisher
    ..In this study, we cloned a cDNA encoding Schistosoma japonicum (S. japonicum) thioredoxin glutathione reductase (SjTGR) from the cDNA of 42-day-old adult worms...
  74. Xu H, Qian H, Zhu W, Zhang X, Yan Y, Mao F, et al. Mesenchymal stem cells relieve fibrosis of Schistosoma japonicum-induced mouse liver injury. Exp Biol Med (Maywood). 2012;237:585-92 pubmed publisher
    ..b>Schistosoma japonicum (S. japonicum) infection is characterized by formation of parasite egg granulomas and host liver fibrosis...
  75. Tokuhiro S, Uda K, Yano H, Nagataki M, Jarilla B, Suzuki T, et al. Phosphagen kinase in Schistosoma japonicum: characterization of its enzymatic properties and determination of its gene structure. Mol Biochem Parasitol. 2013;188:91-8 pubmed publisher
    ..Here, we report the enzymatic properties and gene structure of PK in the trematode Schistosoma japonicum (Sj). SjPK has a unique contiguous dimeric structure comprising domain 1 (D1) and domain 2 (D2)...
  76. Cai P, Piao X, Liu S, Hou N, Wang H, Chen Q. MicroRNA-gene expression network in murine liver during Schistosoma japonicum infection. PLoS ONE. 2013;8:e67037 pubmed publisher
    ..However, the molecular mechanism underling the hepatic pathogenesis is still not clear...
  77. Peng J, Han H, Hong Y, Fu Z, Liu J, Lin J. Molecular cloning and characterization of a gene encoding methionine aminopeptidase 2 of Schistosoma japonicum. Parasitol Res. 2010;107:939-46 pubmed publisher
    ..In the present study, a gene encoding methionine aminopeptidase 2 of Schistosoma japonicum (SjMAP2) was cloned and characterized...
  78. Hu Y, Lu W, Shen Y, Xu Y, Yuan Z, Zhang C, et al. Immune changes of Schistosoma japonicum infections in various rodent disease models. Exp Parasitol. 2012;131:180-9 pubmed publisher
    Rodent models for Schistosoma japonicum infections have demonstrated that these animals possess a degree of resistance to schistosome infections that may be both T and B lymphocyte-mediated...
  79. Song X, Shen J, Wen H, Zhong Z, Luo Q, Chu D, et al. Impact of Schistosoma japonicum infection on collagen-induced arthritis in DBA/1 mice: a murine model of human rheumatoid arthritis. PLoS ONE. 2011;6:e23453 pubmed publisher
    ..The hygiene hypothesis suggests that helminth infections prevent a range of autoimmune diseases...
  80. Yang S, Brindley P, Zeng Q, Li Y, Zhou J, Liu Y, et al. Transduction of Schistosoma japonicum schistosomules with vesicular stomatitis virus glycoprotein pseudotyped murine leukemia retrovirus and expression of reporter human telomerase reverse transcriptase in the transgenic schistosomes. Mol Biochem Parasitol. 2010;174:109-16 pubmed publisher
    Although draft genome sequences of two of the major human schistosomes, Schistosoma japonicum and Schistosoma mansoni are available, the structures and characteristics of most genes and the influence of exogenous genes on the metabolism ..
  81. Qian C, Song L, Hua W, Yin X, Wang J, Zhang W, et al. Kinetics of circulating antigen 14-3-3 in sera of rabbits firstly infected with Schistosoma japonicum and treated with/without praziquantel. Parasitol Res. 2011;108:493-5 pubmed publisher
    ..Rabbits that were infected with 500 cercariae of Schistosoma japonicum were grouped and the kinetics of 14-3-3 was observed...
  82. Wang T, Fang Z, Lei J, Guan F, Liu W, Bartlett A, et al. Delayed tail loss during the invasion of mouse skin by cercariae of Schistosoma japonicum. Parasitology. 2012;139:244-7 pubmed publisher
    ..Furthermore, it was demonstrated that there was a density-dependent increase in DTL as cercarial densities increased. No such density-dependent enhancement was shown for percentage attachment over the same cercarial density range...
  83. Zhu R, Gray D, Thrift A, Williams G, Zhang Y, Qiu D, et al. A 5-year longitudinal study of schistosomiasis transmission in Shian village, the Anning River Valley, Sichuan Province, the Peoples' Republic of China. Parasit Vectors. 2011;4:43 pubmed publisher
    b>Schistosoma japonicum is a major public health concern in the Peoples' Republic of China (PRC), with over one million people infected and another 50 million living in areas at risk of infection...