echinococcus multilocularis

Summary

Summary: A north temperate species of tapeworm (CESTODA) whose adult form infects FOXES and wild RODENTS. The larval form can infect humans producing HEPATIC HYDATID CYSTS.

Top Publications

  1. Danson F, Giraudoux P, Craig P. Spatial modelling and ecology of Echinococcus multilocularis transmission in China. Parasitol Int. 2006;55 Suppl:S227-31 pubmed
    Recent research in central China has suggested that the most likely transmission mechanism for Echinococcus multilocularis to humans is via domestic dogs which are allowed to roam freely and hunt (infected) small mammals within areas ..
  2. Manfredi M, Casulli A, La Rosa G, Di Cerbo A, Trevisio K, Genchi C, et al. Echinococcus multilocularis in north Italy. Parassitologia. 2006;48:43-6 pubmed
    Alveolar echinococcosis is a zoonotic infection caused by the metacestode of the tapeworm Echinococcus multilocularis. Fox populations living in the Alpine regions of Italy had been considered free from this parasite until 2002, when two ..
  3. Stadelmann B, Spiliotis M, Muller J, Scholl S, Muller N, Gottstein B, et al. Echinococcus multilocularis phosphoglucose isomerase (EmPGI): a glycolytic enzyme involved in metacestode growth and parasite-host cell interactions. Int J Parasitol. 2010;40:1563-74 pubmed publisher
    In Echinococcus multilocularis metacestodes, the surface-associated and highly glycosylated laminated layer, and molecules associated with this structure, is believed to be involved in modulating the host-parasite interface...
  4. Stumpe K, Renner Schneiter E, Kuenzle A, Grimm F, Kadry Z, Clavien P, et al. F-18-fluorodeoxyglucose (FDG) positron-emission tomography of Echinococcus multilocularis liver lesions: prospective evaluation of its value for diagnosis and follow-up during benzimidazole therapy. Infection. 2007;35:11-8 pubmed
    ..The rapid improvement of positive PET scans with benzimidazole therapy in some patients indicates that absent FDG uptake does not necessarily reflect parasite viability. ..
  5. Robardet E, Giraudoux P, Caillot C, Boue F, Cliquet F, Augot D, et al. Infection of foxes by Echinococcocus multilocularis in urban and suburban areas of Nancy, France: influence of feeding habits and environment. Parasite. 2008;15:77-85 pubmed
    ..the impact of biological and environmental factors on the infection of red foxes (Vulpes vulpes) by Echinococcus multilocularis in an endemic area of north-east France. From January 2004 to April 2006, 127 foxes were examined for E...
  6. Dubinsky P, Malczewski A, Miterpakova M, Gawor J, Reiterová K. Echinococcus multilocularis in the red fox Vulpes vulpes from the East Carpathian region of Poland and the Slovak Republic. J Helminthol. 2006;80:243-7 pubmed
    The occurrence of Echinococcus multilocularis in the Poland-Slovak frontier zone of the East Carpathian region was assessed, for comparison with that in adjacent regions in both countries...
  7. Mathy A, Hanosset R, Adant S, Losson B. The carriage of larval echinococcus multilocularis and other cestodes by the musk rat (Ondatra zibethicus) along the Ourthe River and its tributaries (Belgium). J Wildl Dis. 2009;45:279-87 pubmed
    In Belgium, the carriage of Echinococcus multilocularis by the red fox (Vulpes vulpes) can be very high in some areas. This study was designed to evaluate the carriage of the larval form of E...
  8. Kouguchi H, Matsumoto J, Katoh Y, Suzuki T, Oku Y, Yagi K. Echinococcus multilocularis: two-dimensional Western blotting method for the identification and expression analysis of immunogenic proteins in infected dogs. Exp Parasitol. 2010;124:238-43 pubmed publisher
    Domesticated dogs are an important potential source of Echinococcus multilocularis infection in humans; therefore, new molecular approaches for the prevention of the parasite infection in dogs need to be developed...
  9. Davidson R, Oines O, Madslien K, Mathis A. Echinococcus multilocularis--adaptation of a worm egg isolation procedure coupled with a multiplex PCR assay to carry out large-scale screening of red foxes (Vulpes vulpes) in Norway. Parasitol Res. 2009;104:509-14 pubmed publisher
    b>Echinococcus multilocularis, causing alveolar echinococcosis in humans, is a highly pathogenic emerging zoonotic disease in central Europe...

More Information

Publications112 found, 100 shown here

  1. Dang Z, Watanabe J, Kajino K, Oku Y, Matsumoto J, Yagi K, et al. Molecular cloning and characterization of a T24-like protein in Echinococcus multilocularis. Mol Biochem Parasitol. 2009;168:117-9 pubmed publisher
    ..One tetraspanin, designated as E24, was cloned from a full-length enriched vector-capping cDNA library of Echinococcus multilocularis metacestode. The amino acid sequence and phylogenetic analysis suggested that E24 is a T24-like protein...
  2. Bernthaler P, Epping K, Schmitz G, Deplazes P, Brehm K. Molecular characterization of EmABP, an apolipoprotein A-I binding protein secreted by the Echinococcus multilocularis metacestode. Infect Immun. 2009;77:5564-71 pubmed publisher
    ..of a novel gene, Emabp, which is expressed by larval stages and adults of the fox tapeworm Echinococcus multilocularis. The encoded protein, EmABP, displays significant homologies to apolipoprotein A-I binding protein (AI-..
  3. Mejri N, Muller J, Gottstein B. Intraperitoneal murine Echinococcus multilocularis infection induces differentiation of TGF-?-expressing DCs that remain immature. Parasite Immunol. 2011;33:471-82 pubmed publisher
    Intraperitoneal larval infection (alveolar echinococcosis, AE) with Echinococcus multilocularis in mice impairs host immunity. Metacestode metabolites may modulate immunity putatively via dendritic cells...
  4. Koizumi A, Hada N, Kaburaki A, Yamano K, Schweizer F, Takeda T. Synthetic studies on the carbohydrate moiety of the antigen from the parasite Echinococcus multilocularis. Carbohydr Res. 2009;344:856-68 pubmed publisher
    ..a Gal beta 1-->3GalNAc core in the glycan portion of the glycoprotein antigen from the parasite Echinococcus multilocularis have been accomplished...
  5. Spiliotis M, Mizukami C, Oku Y, Kiss F, Brehm K, Gottstein B. Echinococcus multilocularis primary cells: improved isolation, small-scale cultivation and RNA interference. Mol Biochem Parasitol. 2010;174:83-7 pubmed publisher
    In this study we demonstrate RNA interference mediated knock-down of target gene expression in Echinococcus multilocularis primary cells on both the transcriptional and translational level...
  6. Peregrine A, Jenkins E, BARNES B, Johnson S, Polley L, Barker I, et al. Alveolar hydatid disease (Echinococcus multilocularis) in the liver of a Canadian dog in British Columbia, a newly endemic region. Can Vet J. 2012;53:870-4 pubmed
    ..of a hepatic mass confirmed the presence of an alveolar hydatid cyst, the first description of Echinococcus multilocularis in British Columbia...
  7. Kouguchi H, Suzuki T, Yamano K, Honma H, Sawada Y. Characterization of various recombinant antigens from Echinococcus multilocularis for use in the immunodiagnosis. Protein J. 2005;24:57-64 pubmed
    Using four clones isolated from Echinococcus multilocularis cDNA library with alveolar echinococcosis (AE) patient sera, various antigens were expressed as ThioHis tag-fused protein...
  8. Fischer C, Reperant L, Weber J, Hegglin D, Deplazes P. Echinococcus multlocularis infections of rural, residential and urban foxes (Vulpes vulpes) in the canton of Geneva, Switzerland. Parasite. 2005;12:339-46 pubmed
    ..267 red foxes (Vulpes vulpes) from the canton of Geneva, Switzerland, for intestinal infections with Echinococcus multilocularis. This region is situated in the core area of the endemic range of this zoonotic cestode in Central ..
  9. Craig P, Larrieu E. Control of cystic echinococcosis/hydatidosis: 1863-2002. Adv Parasitol. 2006;61:443-508 pubmed
    ..The application of new control tools, including use of a hydatid vaccine, are also considered. ..
  10. Andrade M, Siles Lucas M, Espinoza E, Pérez Arellano J, Gottstein B, Muro A. Echinococcus multilocularis laminated-layer components and the E14t 14-3-3 recombinant protein decrease NO production by activated rat macrophages in vitro. Nitric Oxide. 2004;10:150-5 pubmed
    b>Echinococcus multilocularis and Echinococcus granulosus cause alveolar and cystic (unilocular) echinococcosis, respectively, in humans and animals...
  11. Kapel C, Torgerson P, Thompson R, Deplazes P. Reproductive potential of Echinococcus multilocularis in experimentally infected foxes, dogs, raccoon dogs and cats. Int J Parasitol. 2006;36:79-86 pubmed
    ..15 raccoon dogs, 15 domestic dogs and 15 domestic cats were each infected with 20,000 protoscolices of Echinococcus multilocularis. At 35, 63, and 90 days post inoculation (dpi), five animals from each group were necropsied and the ..
  12. Zhang Y, Bart J, Giraudoux P, Craig P, Vuitton D, Wen H. Morphological and molecular characteristics of Echinococcus multilocularis and Echinococcus granulosus mixed infection in a dog from Xinjiang, China. Vet Parasitol. 2006;139:244-8 pubmed
    ..echinococcosis (CE) caused by Echinococcus granulosus, and human alveolar echinococcosis (AE) caused by Echinococcus multilocularis. The domestic dog is suspected to be the primary definitive host for the transmission of both E...
  13. Paul M, Stefaniak J, Rychlicki W, Komarnicki M, Mazur Roszak M. [Role of adhesion molecules in a determination of progression stages and clinical prognosis of patients with Echinococcus multilocularis]. Wiad Parazytol. 2004;50:483-9 pubmed
    ..High serum levels of soluble PECAM-1 molecule were strongly related to the advanced, progressive disease and the fatality of patients' clinical prognosis. ..
  14. Hegglin D, Deplazes P. Control of Echinococcus multilocularis: strategies, feasibility and cost-benefit analyses. Int J Parasitol. 2013;43:327-37 pubmed publisher
    b>Echinococcus multilocularis, the zoonotic agent of human alveolar echinococcosis, has considerably extended its range and became more prevalent in many parts of the endemic areas...
  15. Küster T, Stadelmann B, Hermann C, Scholl S, Keiser J, Hemphill A. In vitro and in vivo efficacies of mefloquine-based treatment against alveolar echinococcosis. Antimicrob Agents Chemother. 2011;55:713-21 pubmed publisher
    Alveolar echinococcosis (AE) is caused by the metacestode stage of the fox tapeworm Echinococcus multilocularis and causes severe disease in the human liver, and occasionally in other organs, that is fatal when treatment is unsuccessful...
  16. Zhang C, Wang J, Lu G, Li J, Lu X, Mantion G, et al. Hepatocyte proliferation/growth arrest balance in the liver of mice during E. multilocularis infection: a coordinated 3-stage course. PLoS ONE. 2012;7:e30127 pubmed publisher
  17. Mejri N, Gottstein B. Intraperitoneal Echinococcus multilocularis infection in C57BL/6 mice affects CD40 and B7 costimulator expression on peritoneal macrophages and impairs peritoneal T cell activation. Parasite Immunol. 2006;28:373-85 pubmed
    ..Taken together, the obstructed presenting-activity of AE-MØs appeared to trigger an unresponsiveness of T cells, contributing to the suppression of their clonal expansion during the chronic phase of AE-infection. ..
  18. Muller N, Frei E, Nunez S, Gottstein B. Improved serodiagnosis of alveolar echinococcosis of humans using an in vitro-produced Echinococcus multilocularis antigen. Parasitology. 2007;134:879-88 pubmed
    ..multilocularis-specific antibody reactivities not detectable by ELISA. ..
  19. Hübner C, Wiehr S, Kocherscheidt L, Wehrl H, Pichler B, Schmid A, et al. Effects of in vitro exposure of Echinococcus multilocularis metacestodes to cytostatic drugs on in vivo growth and proliferation of the parasite. Parasitol Res. 2010;107:459-63 pubmed publisher
    ..and Methotrexate (MTX) were evaluated for their growth inhibitory potential against metacestodes of Echinococcus multilocularis (Em) by in vitro and in vivo assays. In vitro cultures of E...
  20. Beiromvand M, Akhlaghi L, Fattahi Massom S, Mobedi I, Meamar A, Oormazdi H, et al. Detection of Echinococcus multilocularis in carnivores in Razavi Khorasan province, Iran using mitochondrial DNA. PLoS Negl Trop Dis. 2011;5:e1379 pubmed publisher
    b>Echinococcus multilocularis is the source of alveolar echinococcosis, a potentially fatal zoonotic disease. This investigation assessed the presence of E...
  21. Takumi K, van der Giessen J. Transmission dynamics of Echinococcus multilocularis; its reproduction number, persistence in an area of low rodent prevalence, and effectiveness of control. Parasitology. 2005;131:133-40 pubmed
    On the basis of high prevalences of Echinococcus multilocularis in the growing fox populations in Central Europe, its total biomass may have increased significantly in the past 20 years. E...
  22. Giraudoux P, Pleydell D, Raoul F, Quéré J, Wang Q, Yang Y, et al. Transmission ecology of Echinococcus multilocularis: what are the ranges of parasite stability among various host communities in China?. Parasitol Int. 2006;55 Suppl:S237-46 pubmed
    A striking feature of the transmission ecology of Echinococcus multilocularis in China is the diversity of hosts that contribute to the parasite cycle...
  23. Yang Y, Ellis M, Sun T, Li Z, Liu X, Vuitton D, et al. Unique family clustering of human echinococcosis cases in a chinese community. Am J Trop Med Hyg. 2006;74:487-94 pubmed
    ..Although suggestive that host genotype might play a role in susceptibility to AE, this hypothesis requires further investigation...
  24. Tappe D, Kern P, Frosch M, Kern P. A hundred years of controversy about the taxonomic status of Echinococcus species. Acta Trop. 2010;115:167-74 pubmed publisher
    ..In contrast, the natural final and intermediate hosts of Echinococcus multilocularis remained unknown, and the advocates of either theory had to draw on a number of surrogate arguments to ..
  25. Koziol U, Lalanne A, Castillo E. Hox genes in the parasitic platyhelminthes Mesocestoides corti, Echinococcus multilocularis, and Schistosoma mansoni: evidence for a reduced Hox complement. Biochem Genet. 2009;47:100-16 pubmed publisher
    ..directed to the Hox homeobox in the cestode Mesocestoides corti, and we searched genomic assemblies of Echinococcus multilocularis and Schistosoma mansoni. We identified two Hox genes in M. corti, seven in E...
  26. Torgerson P, Deplazes P. Echinococcosis: diagnosis and diagnostic interpretation in population studies. Trends Parasitol. 2009;25:164-70 pubmed publisher
    ..Here, we discuss analytical approaches to population studies of echinococcosis. ..
  27. Brunetti E, Kern P, Vuitton D. Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans. Acta Trop. 2010;114:1-16 pubmed publisher
    ..Among the recognized species, two are of medical importance -Echinococcus granulosus and Echinococcus multilocularis - causing cystic echinococcosis (CE) and alveolar echinococcosis (AE), respectively...
  28. Duscher G, Pleydell D, Prosl H, Joachim A. Echinococcus multilocularis in Austrian foxes from 1991 until 2004. J Vet Med B Infect Dis Vet Public Health. 2006;53:138-44 pubmed
    The prevalence rates of Echinococcus multilocularis in foxes (n=5600) evaluated in several Austrian surveys conducted between 1991 and 2004 were analysed for spatial and temporal differences...
  29. Zhou H, Mo J, Chen G, Bao G, Shi D. [Effect of combined pentoxifylline and albendazole against echinococcus multilocularis infection in mice]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2006;24:333-6 pubmed
    ..of pentoxifylline (PTX), albendazole (ABZ), and a combination of PTX and ABZ in mice infected with Echinococcus multilocularis (E.M). The first part of the experiment was to observe the in vitro effect of PTX on the cultured E...
  30. Knapp J, Guislain M, Bart J, Raoul F, Gottstein B, Giraudoux P, et al. Genetic diversity of Echinococcus multilocularis on a local scale. Infect Genet Evol. 2008;8:367-73 pubmed publisher
    ..These results confirm the usefulness of microsatellite targets for assessing genetic polymorphism in a geographically restricted local range. ..
  31. Berke O, Romig T, von Keyserlingk M. Emergence of Echinococcus multilocularis among Red Foxes in northern Germany, 1991--2005. Vet Parasitol. 2008;155:319-22 pubmed publisher
    The parasite Echinococcus multilocularis is currently of great concern in Europe because of its spreading behavior, which has public health implications...
  32. Moro P, Schantz P. Echinococcosis: a review. Int J Infect Dis. 2009;13:125-33 pubmed publisher
    ..Despite some progress in the control of echinococcosis, this zoonosis continues to be a major public health problem in several countries, and in several others it constitutes an emerging and re-emerging disease. ..
  33. Kern P, Wen H, Sato N, Vuitton D, Gruener B, Shao Y, et al. WHO classification of alveolar echinococcosis: principles and application. Parasitol Int. 2006;55 Suppl:S283-7 pubmed
    Alveolar echinococcosis is caused by the larval stage of the fox tapeworm (Echinococcus multilocularis) and is frequently diagnosed as a space occupying lesion in the liver...
  34. Buttenschoen K, Kern P, Reuter S, Barth T. Hepatic infestation of Echinococcus multilocularis with extension to regional lymph nodes. Langenbecks Arch Surg. 2009;394:699-704 pubmed publisher
    The objective of this paper is to prove lymph node infestation by Echinococcus multilocularis and provide evidence for systematic lymph node dissection in curative resections for alveolar echinococcosis (AE)...
  35. Romig T. Echinococcus multilocularis in Europe--state of the art. Vet Res Commun. 2009;33 Suppl 1:31-4 pubmed publisher
    New information has become available on the epidemiological situation of Echinococcus multilocularis in Europe. Additional endemic areas have been identified, and, in some areas, prevalences in foxes have drastically increased...
  36. Nahorski W, Knap J, Pawłowski Z, Krawczyk M, Polański J, Stefaniak J, et al. Human alveolar echinococcosis in Poland: 1990-2011. PLoS Negl Trop Dis. 2013;7:e1986 pubmed publisher
    Alveolar echinococcosis (AE) caused by Echinococcus multilocularis infections is a dangerous old disease in the Northern Hemisphere. The aim of the paper was to collect and analyze data on human AE in Poland in the last two decades...
  37. Yang Y, Sun T, Li Z, Zhang J, Teng J, Liu X, et al. Community surveys and risk factor analysis of human alveolar and cystic echinococcosis in Ningxia Hui Autonomous Region, China. Bull World Health Organ. 2006;84:714-21 pubmed
    ..Echinococcosis continues to be a severe public health problem in this part of China because of unhygienic practices/habits and poor knowledge among the communities regarding this disease. ..
  38. Knapp J, Bart J, Giraudoux P, Glowatzki M, Breyer I, Raoul F, et al. Genetic diversity of the cestode Echinococcus multilocularis in red foxes at a continental scale in Europe. PLoS Negl Trop Dis. 2009;3:e452 pubmed publisher
    ..echinococcosis (AE) is a severe helminth disease affecting humans, which is caused by the fox tapeworm Echinococcus multilocularis. AE represents a serious public health issue in larger regions of China, Siberia, and other regions in ..
  39. Dinkel A, Kern S, Brinker A, Oehme R, Vaniscotte A, Giraudoux P, et al. A real-time multiplex-nested PCR system for coprological diagnosis of Echinococcus multilocularis and host species. Parasitol Res. 2011;109:493-8 pubmed publisher
    ..probe-based real-time multiplex-nested PCR system was developed for the simultaneous detection of Echinococcus multilocularis and host species directly from faecal samples...
  40. Reperant L, Hegglin D, Tanner I, Fischer C, Deplazes P. Rodents as shared indicators for zoonotic parasites of carnivores in urban environments. Parasitology. 2009;136:329-37 pubmed publisher
    Rodents are shared intermediate or paratenic hosts for Echinococcus multilocularis, Toxocara spp...
  41. Catalano S, Lejeune M, Liccioli S, Verocai G, Gesy K, Jenkins E, et al. Echinococcus multilocularis in urban coyotes, Alberta, Canada. Emerg Infect Dis. 2012;18:1625-8 pubmed publisher
    b>Echinococcus multilocularis is a zoonotic parasite in wild canids. We determined its frequency in urban coyotes (Canis latrans) in Alberta, Canada. We detected E. multilocularis in 23 of 91 coyotes in this region...
  42. Yamano K, Goto A, Nakamura Uchiyama F, Nawa Y, Hada N, Takeda T. Galbeta1-6Gal, antigenic epitope which accounts for serological cross-reaction in diagnosis of Echinococcus multilocularis infection. Parasite Immunol. 2009;31:481-7 pubmed publisher
    ..Our previous study showed that the Galbeta1-6Gal sequence was a common epitope between Echinococcus multilocularis (Em) and E. granulosus (Eg)...
  43. Craig P. Epidemiology of human alveolar echinococcosis in China. Parasitol Int. 2006;55 Suppl:S221-5 pubmed
    ..The role of the dog in transmission of Echinococcus multilocularis to humans now appears to be significant and may be one of the most important risk factor, in ..
  44. Zavala Góngora R, Derrer B, Gelmedin V, Knaus P, Brehm K. Molecular characterisation of a second structurally unusual AR-Smad without an MH1 domain and a Smad4 orthologue from Echinococcus multilocularis. Int J Parasitol. 2008;38:161-76 pubmed
    ..of the receptor-regulated Smad (R-Smad) family, EmSmadA and EmSmadB, from the human parasitic cestode Echinococcus multilocularis and now present evidence for two additional Smads that are expressed by the larval stages of the ..
  45. Matsumoto J, Sakamoto K, Shinjyo N, Kido Y, Yamamoto N, Yagi K, et al. Anaerobic NADH-fumarate reductase system is predominant in the respiratory chain of Echinococcus multilocularis, providing a novel target for the chemotherapy of alveolar echinococcosis. Antimicrob Agents Chemother. 2008;52:164-70 pubmed
    Alveolar echinococcosis, which is due to the massive growth of larval Echinococcus multilocularis, is a life-threatening parasitic zoonosis distributed widely across the northern hemisphere...
  46. Spicher M, Naguleswaran A, Ortega Mora L, Muller J, Gottstein B, Hemphill A. In vitro and in vivo effects of 2-methoxyestradiol, either alone or combined with albendazole, against Echinococcus metacestodes. Exp Parasitol. 2008;119:475-82 pubmed publisher
    The metacestode (larval) stage of the tapeworm Echinococcus multilocularis causes alveolar echinococcosis (AE), a mainly hepatic disease characterized by continuous asexual proliferation of metacestodes by exogenous budding, resulting in ..
  47. Gottstein B, Wittwer M, Schild M, Merli M, Leib S, Muller N, et al. Hepatic gene expression profile in mice perorally infected with Echinococcus multilocularis eggs. PLoS ONE. 2010;5:e9779 pubmed publisher
    ..Despite this severe course and outcome of disease, the genetic program that regulates the host response leading to organ damage as a consequence of hepatic alveolar echinococcosis is largely unknown...
  48. Burlet P, Deplazes P, Hegglin D. Age, season and spatio-temporal factors affecting the prevalence of Echinococcus multilocularis and Taenia taeniaeformis in Arvicola terrestris. Parasit Vectors. 2011;4:6 pubmed publisher
    Taenia taeniaeformis and the related zoonotic cestode Echinococcus multilocularis both infect the water vole Arvicola terrestris...
  49. Nono J, Pletinckx K, Lutz M, Brehm K. Excretory/secretory-products of Echinococcus multilocularis larvae induce apoptosis and tolerogenic properties in dendritic cells in vitro. PLoS Negl Trop Dis. 2012;6:e1516 pubmed publisher
    Alveolar echinococcosis, caused by Echinococcus multilocularis larvae, is a chronic disease associated with considerable modulation of the host immune response...
  50. Mathis A, Wild P, Boettger E, Kapel C, Deplazes P. Mitochondrial ribosome as the target for the macrolide antibiotic clarithromycin in the helminth Echinococcus multilocularis. Antimicrob Agents Chemother. 2005;49:3251-5 pubmed
    The mitochondrial rRNA of the tapeworm species Echinococcus multilocularis carries an adenine at sequence position 2058 (numbering according to that for Escherichia coli) of the large-subunit rRNA (lsrRNA), while the nucleus-encoded rRNA,..
  51. Vuitton D, Zhang S, Yang Y, Godot V, Beurton I, Mantion G, et al. Survival strategy of Echinococcus multilocularis in the human host. Parasitol Int. 2006;55 Suppl:S51-5 pubmed
    ..by "aborted" calcified liver lesions commonly found in patients from endemic areas, Echinococcus multilocularis metacestodes develop only in a minority of individuals exposed to infection with the papasite...
  52. Reuter S, Manfras B, Merkle M, Härter G, Kern P. In vitro activities of itraconazole, methiazole, and nitazoxanide versus Echinococcus multilocularis larvae. Antimicrob Agents Chemother. 2006;50:2966-70 pubmed
    ..the armamentarium against this deadly disease, we tested a series of drugs for their efficacy against Echinococcus multilocularis larvae. E...
  53. Takumi K, de Vries A, Chu M, Mulder J, Teunis P, van der Giessen J. Evidence for an increasing presence of Echinococcus multilocularis in foxes in The Netherlands. Int J Parasitol. 2008;38:571-8 pubmed
    b>Echinococcus multilocularis, a tapeworm causing alveolar echinococcosis which is considered a serious zoonosis known to affect humans, appears to be expanding its geographical range in Europe...
  54. Guislain M, Raoul F, Giraudoux P, Terrier M, Froment G, Ferté H, et al. Ecological and biological factors involved in the transmission of Echinococcus multilocularis in the French Ardennes. J Helminthol. 2008;82:143-51 pubmed publisher
    ..the respective importance of the ecological and biological factors involved in the transmission of Echinococcus multilocularis, we estimated grassland vole intermediate host (Microtus sp...
  55. Antolová D, Reiterová K, Miterpakova M, Dinkel A, Dubinsky P. The first finding of Echinococcus multilocularis in dogs in Slovakia: an emerging risk for spreading of infection. Zoonoses Public Health. 2009;56:53-8 pubmed publisher
    Alveolar echinococcosis, caused by the metacestode Echinococcus multilocularis, is a zoonosis of public health significance. Apart from red foxes, other carnivore species can also serve as definitive hosts of this parasite...
  56. Gelmedin V, Caballero Gamiz R, Brehm K. Characterization and inhibition of a p38-like mitogen-activated protein kinase (MAPK) from Echinococcus multilocularis: antiparasitic activities of p38 MAPK inhibitors. Biochem Pharmacol. 2008;76:1068-81 pubmed publisher
    Alveolar echinococcosis (AE), caused by the metacestode larval stage of the fox-tapeworm Echinococcus multilocularis, is a life-threatening disease with very limited treatment options...
  57. Pohle S, Ernst R, Mackenzie C, Spicher M, Romig T, Hemphill A, et al. Echinococcus multilocularis: the impact of ionizing radiation on metacestodes. Exp Parasitol. 2011;127:127-34 pubmed publisher
    Alveolar echinococcosis is caused by the metacestode stage of the fox tapeworm Echinococcus multilocularis. Current chemotherapeutical options for the treatment of echinococcosis are not satisfactory, and novel drugs and/or other ..
  58. Enemark H, Al Sabi M, Knapp J, Staahl M, Chriel M. Detection of a high-endemic focus of Echinococcus multilocularis in red foxes in southern Denmark, January 2013. Euro Surveill. 2013;18:20420 pubmed
    The Danish surveillance programme for Echinococcus multilocularis was initiated in September 2011, and so far 679 wild carnivores have been examined...
  59. Lidove O, Chauveheid M, Papo T, Vuitton D, Piarroux R, Hernigou A, et al. Echinococcus multilocularis massive pericardial infection: late and dramatic improvement under albendazole therapy. Am J Med. 2005;118:195-7 pubmed
  60. Romig T, Dinkel A, Mackenstedt U. The present situation of echinococcosis in Europe. Parasitol Int. 2006;55 Suppl:S187-91 pubmed
    ..attempt is made to assess the present epidemiological situation in Europe separately for each species (Echinococcus multilocularis, Echinococcus granulosus sensu stricto, Echinococcus equinus, Echinococcus ortleppi, and Echinococcus ..
  61. Thompson R, Kapel C, Hobbs R, Deplazes P. Comparative development of Echinococcus multilocularis in its definitive hosts. Parasitology. 2006;132:709-16 pubmed
    The comparative development of Echinococcus multilocularis was studied in its definitive hosts, the fox, dog, cat and raccoon dog, beyond the pre-patent period to 90 days post-infection...
  62. Yang Y, Craig P, Sun T, Vuitton D, Giraudoux P, Jones M, et al. Echinococcosis in Ningxia Hui Autonomous Region, northwest China. Trans R Soc Trop Med Hyg. 2008;102:319-28 pubmed publisher
  63. Kocherscheidt L, Flakowski A, Grüner B, Hamm D, Dietz K, Kern P, et al. Echinococcus multilocularis: inflammatory and regulatory chemokine responses in patients with progressive, stable and cured alveolar echinococcosis. Exp Parasitol. 2008;119:467-74 pubmed publisher
    The progressive growth of Echinococcus multilocularis metacestodes and their tissue infiltration will cause organ malfunction and finally failure. In few patients, E...
  64. Hegglin D, Deplazes P. Control strategy for Echinococcus multilocularis. Emerg Infect Dis. 2008;14:1626-8 pubmed publisher
    b>Echinococcus multilocularis, the causative agent of zoonotic alveolar echinococcosis, can be controlled effectively by the experimental delivery of anthelminthic baits for urban foxes...
  65. Dvoroznakova E, Porubcová J, Sevcíková Z. Immune response of mice with alveolar echinococcosis to therapy with transfer factor, alone and in combination with albendazole. Parasitol Res. 2009;105:1067-76 pubmed publisher
    The effect of dialysable leucocyte extract (transfer factor TF) on immune response of mice infected with Echinococcus multilocularis and treated with albendazole (ABZ) was observed...
  66. Gelmedin V, Spiliotis M, Brehm K. Molecular characterisation of MEK1/2- and MKK3/6-like mitogen-activated protein kinase kinases (MAPKK) from the fox tapeworm Echinococcus multilocularis. Int J Parasitol. 2010;40:555-67 pubmed publisher
    ..the identification and molecular characterisation of two such molecules in the human parasitic cestode Echinococcus multilocularis, the causative agent of alveolar echinococcosis...
  67. Bao Y, Mao R, Qi H, Zhang Y, Ni Y, Xie Z, et al. [X-ray irradiation against Echinococcus multilocularis protoscoleces in vitro]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2011;29:208-11 pubmed
    To explore the effect of X-ray irradiation on Echinococcus multilocularis protoscoleces in vitro.
  68. Davidson R, Romig T, Jenkins E, Tryland M, Robertson L. The impact of globalisation on the distribution of Echinococcus multilocularis. Trends Parasitol. 2012;28:239-47 pubmed publisher
    In the past three decades, Echinococcus multilocularis, the cause of human alveolar echinococcosis, has been reported in several new countries both in definitive hosts (canids) as well as in people...
  69. Nonaka N, Kamiya M, Oku Y. Towards the control of Echinococcus multilocularis in the definitive host in Japan. Parasitol Int. 2006;55 Suppl:S263-6 pubmed
    b>Echinococcus multilocularis is distributed all over Hokkaido, the northern island of Japan. The prevalence in foxes has been around 40% in the last decade...
  70. Brehm K, Spiliotis M. Recent advances in the in vitro cultivation and genetic manipulation of Echinococcus multilocularis metacestodes and germinal cells. Exp Parasitol. 2008;119:506-15 pubmed publisher
    ..has been relatively successfully carried out in the past is the larval stage of the fox-tapeworm Echinococcus multilocularis, the causative agent of alveolar echinococcosis...
  71. Wang Z, Wang X, Liu X. Echinococcosis in China, a review of the epidemiology of Echinococcus spp. Ecohealth. 2008;5:115-26 pubmed publisher
    ..In addition, human activities and their potential influence on the transmission of echinococcosis are also discussed...
  72. Nonaka N, Kamiya M, Kobayashi F, Ganzorig S, Ando S, Yagi K, et al. Echinococcus multilocularis infection in pet dogs in Japan. Vector Borne Zoonotic Dis. 2009;9:201-6 pubmed publisher
    A survey of Echinococcus multilocularis infections in pet dogs in Japan from 1997 to 2007 was conducted by testing for coproantigen reactivity, fecal taeniid eggs, and egg DNA. In Hokkaido, the only island where E...
  73. McManus D. Reflections on the biochemistry of Echinococcus: past, present and future. Parasitology. 2009;136:1643-52 pubmed publisher
    ..As well, I provide brief insight on new research directions, emphasizing the impact of molecular biology and associated techniques on future studies of Echinococcus and hydatid disease...
  74. McManus D. Echinococcosis with particular reference to Southeast Asia. Adv Parasitol. 2010;72:267-303 pubmed publisher
    ..Chemotherapy has facilitated less invasive surgical management of CE and AE. Nevertheless, as will be emphasised, there is a clear need for new advances in the prevention and control of both these neglected diseases...
  75. Richter D, Richter J, Grüner B, Kranz K, Franz J, Kern P. In vitro efficacy of triclabendazole and clorsulon against the larval stage of Echinococcus multilocularis. Parasitol Res. 2013;112:1655-60 pubmed publisher
    Alveolar echinococcosis (AE) caused by the cestode Echinococcus multilocularis (E. multilocularis) is endemic in wide areas of the Northern hemisphere. Untreated AE progresses and leads to death in more than 90% of cases...
  76. Tsai I, Zarowiecki M, Holroyd N, Garciarrubio A, Sanchez Flores A, Brooks K, et al. The genomes of four tapeworm species reveal adaptations to parasitism. Nature. 2013;496:57-63 pubmed publisher
    ..Here we present an analysis of tapeworm genome sequences using the human-infective species Echinococcus multilocularis, E. granulosus, Taenia solium and the laboratory model Hymenolepis microstoma as examples...
  77. Giraudoux P, Raoul F, Pleydell D, Li T, Han X, Qiu J, et al. Drivers of Echinococcus multilocularis transmission in China: small mammal diversity, landscape or climate?. PLoS Negl Trop Dis. 2013;7:e2045 pubmed publisher
    ..We tested the hypotheses that human disease distribution can be explained by either the biodiversity of small mammal intermediate host species, or by environmental factors such as climate or landscape characteristics...
  78. Giraudoux P, Raoul F, Afonso E, Ziadinov I, Yang Y, Li L, et al. Transmission ecosystems of Echinococcus multilocularis in China and Central Asia. Parasitology. 2013;140:1655-66 pubmed publisher
    From continental to regional scales, the zoonosis alveolar echinococcosis (AE) (caused by Echinococcus multilocularis) forms discrete patches of endemicity within which transmission hotspots of much larger prevalence may occur...
  79. Deplazes P, Grimm F, Sydler T, Tanner I, Kapel C. Experimental alveolar echinococcosis in pigs, lesion development and serological follow up. Vet Parasitol. 2005;130:213-22 pubmed
    Liver lesions were found in 6/6 pigs 7 months after oral inoculation with 5000 or 35,000 Echinococcus multilocularis eggs. However, lesion morphology differed considerably among the animals...
  80. Vervaeke M, van der Giessen J, Brochier B, Losson B, Jordaens K, Verhagen R, et al. Spatial spreading of Echinococcus multilocularis in Red foxes (Vulpes vulpes) across nation borders in Western Europe. Prev Vet Med. 2006;76:137-50 pubmed
    The occurrence of the fox tapeworm Echinococcus multilocularis in Red foxes was studied in Belgium and a neighbouring region in The Netherlands...
  81. Tanner F, Hegglin D, Thoma R, Brosi G, Deplazes P. [Echinococcus multilocularis in Grisons: distribution in foxes and presence of potential intermediate hosts]. Schweiz Arch Tierheilkd. 2006;148:501-10 pubmed
    The southern border of the European endemic area of Echinococcus multilocularis runs along the alpine crest. This endemic transition area was analysed in the canton Grisons on a small spatial scale...
  82. Brehm K, Spiliotis M. The influence of host hormones and cytokines on Echinococcus multilocularis signalling and development. Parasite. 2008;15:286-90 pubmed
    ..Due to its approachability concerning in vitro cultivation, the larval stage of the fox-tapeworm Echinococcus multilocularis has recently emerged as a model system to study the molecular nature of such host-derived stimuli and ..
  83. Nonaka N, Sano T, Inoue T, Teresa Armua M, Fukui D, Katakura K, et al. Multiplex PCR system for identifying the carnivore origins of faeces for an epidemiological study on Echinococcus multilocularis in Hokkaido, Japan. Parasitol Res. 2009;106:75-83 pubmed publisher
    ..identify the carnivore origins of faeces collected in Hokkaido, Japan, for epidemiological studies on Echinococcus multilocularis. Primers were designed against the D-loop region of mitochondrial DNA...
  84. Dang Z, Yagi K, Oku Y, Kouguchi H, Kajino K, Watanabe J, et al. Evaluation of Echinococcus multilocularis tetraspanins as vaccine candidates against primary alveolar echinococcosis. Vaccine. 2009;27:7339-45 pubmed publisher
    b>Echinococcus multilocularis causes an important zoonotic cestode disease. The metacestode stage proliferates in the liver of intermediate hosts including human and rodents and forms multiple cysts...
  85. Hülsmeier A, Deplazes P, Naem S, Nonaka N, Hennet T, KOHLER P. An Echinococcus multilocularis coproantigen is a surface glycoprotein with unique O-gycosylation. Glycobiology. 2010;20:127-35 pubmed publisher
    A major surface constituent of Echinococcus multilocularis adult worms, referred to as an EmA9 antigen, was immunoaffinity purified and identified as a high-molecular-weight glycoconjugate...
  86. Umhang G, Woronoff Rhen N, Combes B, Boue F. Segmental sedimentation and counting technique (SSCT): an adaptable method for qualitative diagnosis of Echinococcus multilocularis in fox intestines. Exp Parasitol. 2011;128:57-60 pubmed publisher
    A modified Segmental Sedimentation and Counting Technique (SSCT) to examine the presence of Echinococcus multilocularis helminths in segments of fox (Vulpes vulpes) intestine is described and compared to the "gold standard", ..
  87. Kouguchi H, Matsumoto J, Yamano K, Katoh Y, Oku Y, Suzuki T, et al. Echinococcus multilocularis: purification and characterization of glycoprotein antigens with serodiagnostic potential for canine infection. Exp Parasitol. 2011;128:50-6 pubmed publisher
    We show that a conventionally purified glycoprotein component of Echinococcus multilocularis protoscolex, designated as Emgp-89, may be useful as a serodiagnostic antigen for detecting E...
  88. Piarroux M, Piarroux R, Giorgi R, Knapp J, Bardonnet K, Sudre B, et al. Clinical features and evolution of alveolar echinococcosis in France from 1982 to 2007: results of a survey in 387 patients. J Hepatol. 2011;55:1025-33 pubmed publisher
    Alveolar echinococcosis (AE) is a rare disease in humans, caused by the larval stage of the fox tapeworm Echinococcus multilocularis.
  89. van Dommelen L, Stoot J, Cappendijk V, Abdul Hamid M, Stelma F, Kortbeek L, et al. The first locally acquired human infection of Echinococcus multilocularis in The Netherlands. J Clin Microbiol. 2012;50:1818-20 pubmed publisher
    In the northern part of Western Europe, Echinococcus multilocularis is primarily detected in and spreading among foxes. The present case marks E...
  90. Bart J, Knapp J, Gottstein B, El Garch F, Giraudoux P, Glowatzki M, et al. EmsB, a tandem repeated multi-loci microsatellite, new tool to investigate the genetic diversity of Echinococcus multilocularis. Infect Genet Evol. 2006;6:390-400 pubmed
    In order to explore the genetic diversity within Echinococcus multilocularis (E...
  91. Morishima Y, Sugiyama H, Arakawa K, Kawanaka M. Echinococcus multilocularis in dogs, Japan. Emerg Infect Dis. 2006;12:1292-4 pubmed
  92. Zhang S, Hue S, Sene D, Penfornis A, Bresson Hadni S, Kantelip B, et al. Expression of major histocompatibility complex class I chain-related molecule A, NKG2D, and transforming growth factor-beta in the liver of humans with alveolar echinococcosis: new actors in the tolerance to parasites?. J Infect Dis. 2008;197:1341-9 pubmed publisher
    b>Echinococcus multilocularis growth and persistent granuloma, which lead to the development of the severe parasitic disease alveolar echinococcosis (AE), might be caused by abnormal expression of stress-induced proteins, with subsequent ..