haemonchus

Summary

Summary: A genus of parasitic nematode worms which infest the duodenum and stomach of domestic and wild herbivores, which ingest it with the grasses (POACEAE) they eat. Infestation of man is accidental.

Top Publications

  1. Redmond D, Knox D. Further protection studies using recombinant forms of Haemonchus contortus cysteine proteinases. Parasite Immunol. 2006;28:213-9 pubmed
    Significant levels of protection against Haemonchus contortus have been achieved in sheep by vaccination with a cysteine proteinase-enriched fraction (TSBP) isolated from the gut of adult parasites...
  2. Terefe G, Grisez C, Prevot F, Bergeaud J, Dorchies P, Brunel J, et al. In vitro pre-exposure of Haemonchus contortus L3 to blood eosinophils reduces their establishment potential in sheep. Vet Res. 2007;38:647-54 pubmed
    ..The objective of this experimental study was therefore to substantiate the role of eosinophils in the killing of Haemonchus contortus infective larvae by comparing the infectivity in sheep of larvae that had been incubated with ..
  3. Cantacessi C, Campbell B, Young N, Jex A, Hall R, Presidente P, et al. Differences in transcription between free-living and CO2-activated third-stage larvae of Haemonchus contortus. BMC Genomics. 2010;11:266 pubmed publisher
    The disease caused by Haemonchus contortus, a blood-feeding nematode of small ruminants, is of major economic importance worldwide...
  4. Murray L, Geldhof P, Clark D, Knox D, Britton C. Expression and purification of an active cysteine protease of Haemonchus contortus using Caenorhabditis elegans. Int J Parasitol. 2007;37:1117-25 pubmed
    ..In an effort to overcome these difficulties we have tested Caenorhabditis elegans as an expression system for a Haemonchus contortus cathepsin L cysteine protease, Hc-CPL-1...
  5. Rufener L, Baur R, Kaminsky R, Maser P, Sigel E. Monepantel allosterically activates DEG-3/DES-2 channels of the gastrointestinal nematode Haemonchus contortus. Mol Pharmacol. 2010;78:895-902 pubmed publisher
    ..derivatives (AAD), presently used to treat ruminants infected with gastrointestinal nematodes such as Haemonchus contortus...
  6. Cudeková P, Várady M, Dolinská M, Königová A. Phenotypic and genotypic characterisation of benzimidazole susceptible and resistant isolates of Haemonchus contortus. Vet Parasitol. 2010;172:155-9 pubmed publisher
    ..polymerase chain reaction PCR (AS-PCR) methods as tools for detection of benzimidazole resistance in Haemonchus contortus, a nematode parasite of small ruminants...
  7. Buckingham S, Sattelle D. Fast, automated measurement of nematode swimming (thrashing) without morphometry. BMC Neurosci. 2009;10:84 pubmed publisher
    ..Furthermore, the algorithm successfully measured the actions of levamisole on a parasitic nematode, Haemonchus contortus, which undergoes complex contorted shapes whilst swimming, without alterations in the code or of any ..
  8. Rocha R, Bricarello P, Silva M, Houdijk J, Almeida F, Cardia D, et al. Influence of protein supplementation during late pregnancy and lactation on the resistance of Santa Ines and Ile de France ewes to Haemonchus contortus. Vet Parasitol. 2011;181:229-38 pubmed publisher
    ..experiment aimed to evaluate the effect of periparturient metabolizable protein (MP) nutrition on resistance to Haemonchus contortus in single rearing Ile de France and Santa Ines ewes...
  9. Sahoo S, Murugavel S, Devi I, Vedamurthy G, Gupta S, Singh B, et al. Glyceraldehyde-3-phosphate dehydrogenase of the parasitic nematode Haemonchus contortus binds to complement C3 and inhibits its activity. Parasite Immunol. 2013;35:457-67 pubmed publisher
    b>Haemonchus contortus is an economically important gastrointestinal parasite that infects primarily sheep and goats. To survive inside the host, the parasite must overcome the host immune response...

More Information

Publications102 found, 100 shown here

  1. Zawadzki J, Presidente P, Meeusen E, de Veer M. RNAi in Haemonchus contortus: a potential method for target validation. Trends Parasitol. 2006;22:495-9 pubmed
    ..There have been several attempts to apply this method to parasitic nematodes. In a recent study undertaken in Haemonchus contortus, Geldhof and colleagues concluded that, although a mechanism for RNAi existed, the methods developed ..
  2. Redman E, Packard E, Grillo V, Smith J, Jackson F, Gilleard J. Microsatellite analysis reveals marked genetic differentiation between Haemonchus contortus laboratory isolates and provides a rapid system of genetic fingerprinting. Int J Parasitol. 2008;38:111-22 pubmed
    Many of the Haemonchus contortus isolates currently used for experimental work were originally derived from different regions of the world and are commonly exchanged between laboratories...
  3. Rowe A, McMaster K, Emery D, Sangster N. Haemonchus contortus infection in sheep: parasite fecundity correlates with worm size and host lymphocyte counts. Vet Parasitol. 2008;153:285-93 pubmed publisher
    Two experiments were conducted to elucidate the timing and nature of the sheep immune response to Haemonchus contortus (Barber's pole worm). The first experiment examined the establishment of H...
  4. MacKinnon K, Burton J, Zajac A, Notter D. Microarray analysis reveals difference in gene expression profiles of hair and wool sheep infected with Haemonchus contortus. Vet Immunol Immunopathol. 2009;130:210-20 pubmed publisher
    Sheep infected with the abomasal parasite, Haemonchus contortus, have reduced growth rates, decreased wool production, and anemia, and heavy infections may result in death...
  5. de Vries E, Bakker N, Krijgsveld J, Knox D, Heck A, Yatsuda A. An AC-5 cathepsin B-like protease purified from Haemonchus contortus excretory secretory products shows protective antigen potential for lambs. Vet Res. 2009;40:41 pubmed publisher
    The immunogenic properties of cysteine proteases obtained from excretory/secretory products (ES) of Haemonchus contortus were investigated with a fraction purified with a recombinant H. contortus cystatin affinity column...
  6. Graham L, Kotze A, Fernley R, Hill R. An ortholog of the ecdysone receptor protein (EcR) from the parasitic nematode Haemonchus contortus. Mol Biochem Parasitol. 2010;171:104-7 pubmed publisher
    High concentrations (> or =4.2mM) of 20E inhibit the development of Haemonchus contortus eggs to the L3 larval stage. We report the cloning of cDNA encoding an EcR ortholog (HcEcR) from H. contortus mRNA expressed during L3...
  7. Umair S, Knight J, Patchett M, Bland R, Simpson H. Nucleotide allosteric regulation of the glutamate dehydrogenases of Teladorsagia circumcincta and Haemonchus contortus. Comp Biochem Physiol B Biochem Mol Biol. 2012;161:255-60 pubmed publisher
    The expression of glutamate dehydrogenase (GDH; EC 1.4.1.3) in L3 of the nematode Haemonchus contortus was confirmed by detecting GDH mRNA, contrary to earlier reports. The enzyme was active in both L3 and adult H...
  8. Yacob H, Mistre C, Adem A, Basu A. Parasitological and clinical responses of lambs experimentally infected with Haemonchus contortus (L3) with and without ivermectin treatment. Vet Parasitol. 2009;166:119-23 pubmed publisher
    b>Haemonchus contortus is one of the most important parasites that infects sheep and exerts its pathogenic effects by sucking blood, causing disturbances of organ-functions and thus inducing alterations in various normal physiological ..
  9. Muñoz Guzmán M, Cuenca Verde C, Valdivia Anda G, Cuéllar Ordaz J, Alba Hurtado F. Differential immune response between fundic and pyloric abomasal regions upon experimental ovine infection with Haemonchus contortus. Vet Parasitol. 2012;185:175-80 pubmed publisher
    ..These differences indicate that the immunological response is not homogenous in all abomasal mucosa and that evaluating the response from a single abomasal region may not be representative of the cellular response across the abomasum...
  10. Galindo Barboza A, Torres Acosta J, Cámara Sarmiento R, Sandoval Castro C, Aguilar Caballero A, Ojeda Robertos N, et al. Persistence of the efficacy of copper oxide wire particles against Haemonchus contortus in sheep. Vet Parasitol. 2011;176:201-7 pubmed publisher
    The aim was to determine the persistent efficacy of copper oxide wire particles (COWP) against Haemonchus contortus in sheep, using the harmonization guidelines protocol...
  11. von Samson Himmelstjerna G, Walsh T, Donnan A, Carriere S, Jackson F, Skuce P, et al. Molecular detection of benzimidazole resistance in Haemonchus contortus using real-time PCR and pyrosequencing. Parasitology. 2009;136:349-58 pubmed publisher
    ..In the present study, we investigated beta-tubulin isotype 1 sequences of 18 Haemonchus contortus isolates with varying levels of resistance to thiabendazole...
  12. Learmount J, Conyers C, Hird H, Morgan C, Craig B, von Samson Himmelstjerna G, et al. Development and validation of real-time PCR methods for diagnosis of Teladorsagia circumcincta and Haemonchus contortus in sheep. Vet Parasitol. 2009;166:268-74 pubmed publisher
    ..to develop and test a real-time PCR method for routine diagnosis of infection by Teladorsagia circumcincta and Haemonchus contortus in sheep...
  13. van Wyk J, Reynecke D. Blueprint for an automated specific decision support system for countering anthelmintic resistance in Haemonchus spp. at farm level. Vet Parasitol. 2011;177:212-23 pubmed publisher
  14. Hunt P, Knox M, Le Jambre L, McNally J, Anderson L. Genetic and phenotypic differences between isolates of Haemonchus contortus in Australia. Int J Parasitol. 2008;38:885-900 pubmed
    We believe this study is the first to consider the genetic and phenotypic divergence between isolates of Haemonchus contortus in Australia...
  15. Rufener L, Maser P, Roditi I, Kaminsky R. Haemonchus contortus acetylcholine receptors of the DEG-3 subfamily and their role in sensitivity to monepantel. PLoS Pathog. 2009;5:e1000380 pubmed publisher
    Gastro-intestinal nematodes in ruminants, especially Haemonchus contortus, are a global threat to sheep and cattle farming...
  16. Terefe G, Lacroux C, Prevot F, Grisez C, Bergeaud J, Bleuart C, et al. Eosinophils in Haemonchus contortus-infected resistant and susceptible breeds of sheep: abomasal tissue recruitment and in vitro functional state. Vet Parasitol. 2009;165:161-4 pubmed publisher
    ..Barbados Black Belly (resistant) and INRA-401 (susceptible) breeds of sheep in which primary infection with Haemonchus contortus was terminated on day 16...
  17. Muleke C, Ruofeng Y, Lixin X, Xinwen B, Xiangrui L. Cloning and sequence analysis of Hemonchus contortus HC58cDNA. DNA Seq. 2007;18:176-83 pubmed
    ..Phylogenetic analysis revealed close evolutionary proximity of the protein sequence to counterpart sequences in the CBL, suggesting that HC58cDNA was a member of the papain family. ..
  18. Blackhall W, Prichard R, Beech R. P-glycoprotein selection in strains of Haemonchus contortus resistant to benzimidazoles. Vet Parasitol. 2008;152:101-7 pubmed publisher
    ..In Haemonchus contortus, resistance to avermectins has been correlated with genetic changes at a gene encoding a P-..
  19. Yin Y, Martin J, Abubucker S, Scott A, McCarter J, Wilson R, et al. Intestinal transcriptomes of nematodes: comparison of the parasites Ascaris suum and Haemonchus contortus with the free-living Caenorhabditis elegans. PLoS Negl Trop Dis. 2008;2:e269 pubmed publisher
    ..However, the lack of detailed knowledge on the molecular and cellular functions of the intestine and the level of its conservation across nematodes has impeded breakthroughs in this application...
  20. Scheuerle M, Mahling M, Pfister K. Anthelminthic resistance of Haemonchus contortus in small ruminants in Switzerland and Southern Germany. Wien Klin Wochenschr. 2009;121 Suppl 3:46-9 pubmed publisher
    ..3%, respectively, thus also demonstrating resistance against macrocyclic lactones. Pre- and post-treatment faecal larval cultures revealed Haemonchus contortus as the predominant resistant species.
  21. Nikolaou S, Gasser R. Prospects for exploring molecular developmental processes in Haemonchus contortus. Int J Parasitol. 2006;36:859-68 pubmed
    b>Haemonchus contortus of small ruminants is a parasitic nematode of major socio-economic importance world-wide. While there is considerable knowledge of the morphological changes which take place during the life cycle of H...
  22. McCavera S, Rogers A, Yates D, Woods D, Wolstenholme A. An ivermectin-sensitive glutamate-gated chloride channel from the parasitic nematode Haemonchus contortus. Mol Pharmacol. 2009;75:1347-55 pubmed publisher
    ..In Xenopus laevis oocytes, channels formed by the GluClalpha3B subunit from the parasite Haemonchus contortus were more sensitive to l-glutamate (EC(50) = 27.6 +/- 2...
  23. Prince L, Gowane G, Swarnkar C, Singh D, Arora A. Estimates of genetic parameters for faecal egg count of Haemonchus contortus infection and relationship with growth traits in Avikalin sheep. Trop Anim Health Prod. 2010;42:785-91 pubmed publisher
    ..Result suggests that direct genetic and maternal permanent environmental effects were important for this trait; thus, they need to be considered for improvement in the trait. ..
  24. Squires J, Ferreira J, Lindsay D, Zajac A. Effects of artemisinin and Artemisia extracts on Haemonchus contortus in gerbils (Meriones unguiculatus). Vet Parasitol. 2011;175:103-8 pubmed publisher
    b>Haemonchus contortus is a blood-sucking abomasal parasite of small ruminants that is responsible for major losses to producers worldwide...
  25. Maciel M, Morais S, Bevilaqua C, Camurça Vasconcelos A, Costa C, Castro C. Ovicidal and larvicidal activity of Melia azedarach extracts on Haemonchus contortus. Vet Parasitol. 2006;140:98-104 pubmed
    b>Haemonchus contortus is responsible for severe economic losses in sheep and goat breeding in the Northeast of Brazil. However, the effectiveness of control is compromised due to anthelmintic resistance and misuse...
  26. Redman E, Grillo V, Saunders G, Packard E, Jackson F, Berriman M, et al. Genetics of mating and sex determination in the parasitic nematode Haemonchus contortus. Genetics. 2008;180:1877-87 pubmed publisher
    ..b>Haemonchus contortus is one of the most economically significant livestock parasites worldwide and is a key experimental ..
  27. Kemper K, Elwin R, Bishop S, Goddard M, Woolaston R. Haemonchus contortus and Trichostrongylus colubriformis did not adapt to long-term exposure to sheep that were genetically resistant or susceptible to nematode infections. Int J Parasitol. 2009;39:607-14 pubmed publisher
    We tested the hypothesis that Haemonchus contortus and Trichostrongylus colubriformis would adapt to long-term exposure to sheep that were either genetically resistant or susceptible to H. contortus...
  28. Angulo Cubillán F, García Coiradas L, Alunda J, Cuquerella M, de la Fuente C. Biological characterization and pathogenicity of three Haemonchus contortus isolates in primary infections in lambs. Vet Parasitol. 2010;171:99-105 pubmed publisher
    The biological characterization and differential pathogenicity of three isolates of Haemonchus contortus, one autochthonous (Aran 99) and two allochthonous (Moredun Research Institute, MRI, and Merck Sharp and Dohme, MSD) were studied by ..
  29. Lloberas M, Alvarez L, Entrocasso C, Virkel G, Lanusse C, Lifschitz A. Measurement of ivermectin concentrations in target worms and host gastrointestinal tissues: influence of the route of administration on the activity against resistant Haemonchus contortus in lambs. Exp Parasitol. 2012;131:304-9 pubmed publisher
    ..in the bloodstream, the gastrointestinal mucosal tissues/fluid contents and within a target abomasal parasite (Haemonchus contortus) was evaluated in lambs...
  30. Welz C, Krüger N, Schniederjans M, Miltsch S, Krucken J, Guest M, et al. SLO-1-channels of parasitic nematodes reconstitute locomotor behaviour and emodepside sensitivity in Caenorhabditis elegans slo-1 loss of function mutants. PLoS Pathog. 2011;7:e1001330 pubmed publisher
    ..In this study we identified orthologues of slo-1 in Ancylostoma caninum, Cooperia oncophora, and Haemonchus contortus, all important parasitic nematodes in veterinary medicine...
  31. Gilleard J. Haemonchus contortus as a paradigm and model to study anthelmintic drug resistance. Parasitology. 2013;140:1506-22 pubmed publisher
    ..b>Haemonchus contortus, a gastro-intestinal parasite of sheep, has shown a remarkable propensity to develop resistance to all ..
  32. Ingham A, Reverter A, Windon R, Hunt P, Menzies M. Gastrointestinal nematode challenge induces some conserved gene expression changes in the gut mucosa of genetically resistant sheep. Int J Parasitol. 2008;38:431-42 pubmed
    ..Expression profiles were determined in response to two different nematode species, Haemonchus contortus and Trichostrongylus colubriformis, and in divergent sheep originating from two different genetic ..
  33. Campbell B, Nisbet A, Mulvenna J, Loukas A, Gasser R. Molecular and phylogenetic characterization of cytochromes c from Haemonchus contortus and Trichostrongylus vitrinus (Nematoda: Trichostrongylida). Gene. 2008;424:121-9 pubmed publisher
    ..In the present study, we investigated this group of molecules in Haemonchus contortus (barber's pole worm) and Trichostrongylus vitrinus (black scour worm), two parasitic nematodes of ..
  34. Han K, Xu L, Yan R, Song X, Li X. Molecular cloning, expression and characterization of enolase from adult Haemonchus contortus. Res Vet Sci. 2012;92:259-65 pubmed publisher
    ..In the present research, the enolase gene of Haemonchus contortus (HcENO) was cloned and characterized...
  35. Brasil B, Nunes R, Bastianetto E, Drummond M, Carvalho D, Leite R, et al. Genetic diversity patterns of Haemonchus placei and Haemonchus contortus populations isolated from domestic ruminants in Brazil. Int J Parasitol. 2012;42:469-79 pubmed
    Parasitic nematodes of the genus Haemonchus infect a range of ruminant hosts and are of major veterinary and economic importance...
  36. Eng J, Blackhall W, Osei Atweneboana M, Bourguinat C, Galazzo D, Beech R, et al. Ivermectin selection on beta-tubulin: evidence in Onchocerca volvulus and Haemonchus contortus. Mol Biochem Parasitol. 2006;150:229-35 pubmed
    Ivermectin resistance is common in trichostrongylid nematodes of livestock, such as Haemonchus contortus...
  37. Walsh T, Donnan A, Jackson F, Skuce P, Wolstenholme A. Detection and measurement of benzimidazole resistance alleles in Haemonchus contortus using real-time PCR with locked nucleic acid Taqman probes. Vet Parasitol. 2007;144:304-12 pubmed
    ..In Haemonchus contortus a single nucleotide polymorphism at codon 200 of the beta-tubulin gene (TTC to TAC), causing a ..
  38. Sotirchos I, Hudson A, Ellis J, Davey M. Thioredoxins of a parasitic nematode: comparison of the 16- and 12-kDA thioredoxins from Haemonchus contortus. Free Radic Biol Med. 2008;44:2026-33 pubmed publisher
    ..We report that in the parasitic nematode Haemonchus contortus, both the 12-kDa (HcTrx1) and the 16-kDa (HcTrx3) species are expressed through the life cycle...
  39. Marshall K, Maddox J, Lee S, Zhang Y, Kahn L, Graser H, et al. Genetic mapping of quantitative trait loci for resistance to Haemonchus contortus in sheep. Anim Genet. 2009;40:262-72 pubmed publisher
    This paper presents results from a mapping experiment to detect quantitative trait loci (QTL) for resistance to Haemonchus contortus infestation in merino sheep...
  40. Vatta A, Waller P, Githiori J, Medley G. The potential to control Haemonchus contortus in indigenous South African goats with copper oxide wire particles. Vet Parasitol. 2009;162:306-13 pubmed publisher
    The high prevalence of resistance of Haemonchus contortus to all major anthelmintic groups has prompted investigations into alternative control methods in South Africa, including the use of copper oxide wire particle (COWP) boluses...
  41. Winter A, Weir W, Hunt M, Berriman M, Gilleard J, Devaney E, et al. Diversity in parasitic nematode genomes: the microRNAs of Brugia pahangi and Haemonchus contortus are largely novel. BMC Genomics. 2012;13:4 pubmed publisher
    ..Here we describe the the miRNA repertoire of two important parasitic nematodes as an essential first step in addressing this question...
  42. Nagaraj S, Harsha H, Reverter A, Colgrave M, Sharma R, Andronicos N, et al. Proteomic analysis of the abomasal mucosal response following infection by the nematode, Haemonchus contortus, in genetically resistant and susceptible sheep. J Proteomics. 2012;75:2141-52 pubmed publisher
    ..Samples were collected from the abomasal mucosa three days after experimental challenge with the nematode, Haemonchus contortus...
  43. Balic A, Cunningham C, Meeusen E. Eosinophil interactions with Haemonchus contortus larvae in the ovine gastrointestinal tract. Parasite Immunol. 2006;28:107-15 pubmed
    Sheep were immunized by weekly oral infections with Haemonchus contortus for 9 weeks followed by anthelmintic treatment...
  44. Miller J, Horohov D. Immunological aspects of nematode parasite control in sheep. J Anim Sci. 2006;84 Suppl:E124-32 pubmed
    ..The nematode of particular concern is Haemonchus contortus, which can cause severe blood loss resulting in anemia, anorexia, depression, loss of condition, and ..
  45. Gilleard J. Understanding anthelmintic resistance: the need for genomics and genetics. Int J Parasitol. 2006;36:1227-39 pubmed
    ..However, these are now being developed for the trichostrongylid nematode Haemonchus contortus and the current progress and research priorities in this area are discussed.
  46. Jasmer D, Lahmers K, Brown W. Haemonchus contortus intestine: a prominent source of mucosal antigens. Parasite Immunol. 2007;29:139-51 pubmed
    We sought to identify antigens from Haemonchus contortus, an abomasal nematode of small ruminants, that stimulate local (abomasal lymph node, ALN) CD4+ T lymphocyte responses during a primary infection...
  47. Kaplan R, Vidyashankar A, Howell S, Neiss J, Williamson L, Terrill T. A novel approach for combining the use of in vitro and in vivo data to measure and detect emerging moxidectin resistance in gastrointestinal nematodes of goats. Int J Parasitol. 2007;37:795-804 pubmed
    ..The larval development assay (LDA) is routinely used to diagnose ivermectin resistance in Haemonchus contortus but laboratory diagnosis of moxidectin resistance is hampered by the lack of any validated in vitro ..
  48. Sotirchos I, Hudson A, Ellis J, Davey M. A unique thioredoxin of the parasitic nematode Haemonchus contortus with glutaredoxin activity. Free Radic Biol Med. 2009;46:579-85 pubmed publisher
    ..Here we describe the identification of a unique thioredoxin in the parasitic nematode, Haemonchus contortus...
  49. Shakya K, Miller J, Horohov D. A Th2 type of immune response is associated with increased resistance to Haemonchus contortus in naturally infected Gulf Coast Native lambs. Vet Parasitol. 2009;163:57-66 pubmed publisher
    b>Haemonchus contortus is one of the major nematode parasites causing substantial economic losses in small ruminant farming worldwide...
  50. Li C, Wei X, Xu L, Li X. Recombinant galectins of male and female Haemonchus contortus do not hemagglutinate erythrocytes of their natural host. Vet Parasitol. 2007;144:299-303 pubmed
    Recombinant galectins of female and male adult worms of Haemonchus contortus were expressed in Escherichia coli and their hemagglutinating activities to human and different animal erythrocytes were analyzed...
  51. Rowe A, Gondro C, Emery D, Sangster N. Genomic analyses of Haemonchus contortus infection in sheep: abomasal fistulation and two Haemonchus strains do not substantially confound host gene expression in microarrays. Vet Parasitol. 2008;154:71-81 pubmed publisher
    To determine whether fistulation and differing strains of Haemonchus contortus complicate genome analysis of the host response to infection, two pilot experiments examined parasite development and gene expression in the abomasal mucosa of ..
  52. Kemp J, Robinson N, Meeusen E, Piedrafita D. The relationship between the rapid rejection of Haemonchus contortus larvae with cells and mediators in abomasal tissues in immune sheep. Int J Parasitol. 2009;39:1589-94 pubmed publisher
    ..tissue explant model to examine in more detail the cells and mediators involved in preventing establishment of Haemonchus contortus L3s in abomasal tissue of sensitised sheep...
  53. Cachat E, Newlands G, Ekoja S, McAllister H, Smith W. Attempts to immunize sheep against Haemonchus contortus using a cocktail of recombinant proteases derived from the protective antigen, H-gal-GP. Parasite Immunol. 2010;32:414-9 pubmed publisher
    ..expressed versions of most of the protective proteases of H-gal-GP, a known protective antigen from Haemonchus contortus, would confer any protection to lambs in a vaccine-challenge trial...
  54. Martinez Ortiz de Montellano C, Vargas Magaña J, Canul Ku H, Miranda Soberanis R, Capetillo Leal C, Sandoval Castro C, et al. Effect of a tropical tannin-rich plant Lysiloma latisiliquum on adult populations of Haemonchus contortus in sheep. Vet Parasitol. 2010;172:283-90 pubmed publisher
    ..latisiliquum fodder consumption on adult Haemonchus contortus. Twenty-two parasite-naïve hair sheep lambs were allocated to an infected group (I) (400H...
  55. Bambou J, Archimede H, Arquet R, Mahieu M, Alexandre G, Gonzalez Garcia E, et al. Effect of dietary supplementation on resistance to experimental infection with Haemonchus contortus in Creole kids. Vet Parasitol. 2011;178:279-85 pubmed publisher
    ..the present study was to test the effect of dietary supplementation on resistance to experimental infection with Haemonchus contortus in Creole kids...
  56. Saddiqi H, Jabbar A, Sarwar M, Iqbal Z, Muhammad G, Nisa M, et al. Small ruminant resistance against gastrointestinal nematodes: a case of Haemonchus contortus. Parasitol Res. 2011;109:1483-500 pubmed publisher
    ..This paper reviews the published reports on natural resistance in small ruminants and discusses the prospects of developing small ruminants, which could be resistant to GINs...
  57. Troell K, Engström A, Morrison D, Mattsson J, Hoglund J. Global patterns reveal strong population structure in Haemonchus contortus, a nematode parasite of domesticated ruminants. Int J Parasitol. 2006;36:1305-16 pubmed
    We have examined the global population genetic structure of Haemonchus contortus. The genetic variability was studied using both amplified fragment length polymorphism (AFLP) and nad4 sequences of the mitochondrial genome...
  58. Bethony J, Loukas A, Hotez P, Knox D. Vaccines against blood-feeding nematodes of humans and livestock. Parasitology. 2006;133 Suppl:S63-79 pubmed
    ..towards vaccine development against the major blood-feeding nematodes of man and livestock, the hookworms and Haemonchus contortus, respectively...
  59. Burke J, Kaplan R, Miller J, Terrill T, Getz W, Mobini S, et al. Accuracy of the FAMACHA system for on-farm use by sheep and goat producers in the southeastern United States. Vet Parasitol. 2007;147:89-95 pubmed
    ..a practical on-farm system designed to provide small ruminant producers a tool for improving their management of Haemonchus contortus infections...
  60. González J, Hernandez A, Molina J, Fernandez A, Raadsma H, Meeusen E, et al. Comparative experimental Haemonchus contortus infection of two sheep breeds native to the Canary Islands. Vet Parasitol. 2008;153:374-8 pubmed publisher
    This study compares the susceptibility to Haemonchus contortus infection in two breeds of sheep endemic to the Canary Islands, the Canaria Hair Breed sheep and the Canaria sheep. Sheep were experimentally infected with 20,000 larvae of H...
  61. Naresha S, Suryawanshi A, Agarwal M, Singh B, Joshi P. Mapping the complement C1q binding site in Haemonchus contortus calreticulin. Mol Biochem Parasitol. 2009;166:42-6 pubmed publisher
    b>Haemonchus contortus is an economically important gastrointestinal parasite of domestic animals. The parasite secretes calreticulin (CalR), a Ca(++) binding protein which modulates the host immune response...
  62. Beech R, Levitt N, Cambos M, Zhou S, Forrester S. Association of ion-channel genotype and macrocyclic lactone sensitivity traits in Haemonchus contortus. Mol Biochem Parasitol. 2010;171:74-80 pubmed publisher
    Resistance to macrocyclic lactones in the strongylid parasite of sheep, Haemonchus contortus, is associated with specific alleles of several genes, including those encoding ligand-gated chloride-channels...
  63. Salle G, Jacquiet P, Gruner L, Cortet J, Sauve C, Prevot F, et al. A genome scan for QTL affecting resistance to Haemonchus contortus in sheep. J Anim Sci. 2012;90:4690-705 pubmed publisher
    ..To identify loci affecting the resistance to Haemonchus contortus, a genome scan was carried out using 1,275 Romane × Martinik Black Belly backcross lambs...
  64. Piedrafita D, de Veer M, Sherrard J, Kraska T, Elhay M, Meeusen E. Field vaccination of sheep with a larval-specific antigen of the gastrointestinal nematode, Haemonchus contortus, confers significant protection against an experimental challenge infection. Vaccine. 2012;30:7199-204 pubmed publisher
    ..treated with anthelmintic 8 weeks before vaccination with a larval surface antigen of the nematode parasite, Haemonchus contortus, under a commercially acceptable protocol, i.e...
  65. Akkari H, Jebali J, Gharbi M, Mhadhbi M, Awadi S, Darghouth M. Epidemiological study of sympatric Haemonchus species and genetic characterization of Haemonchus contortus in domestic ruminants in Tunisia. Vet Parasitol. 2013;193:118-25 pubmed publisher
    Parasitic gastroenteritis caused by Haemonchus spp. is a major cause of economic losses in the livestock industry, especially in tropical and subtropical areas...
  66. Kotze A, Le Jambre L, O Grady J. A modified larval migration assay for detection of resistance to macrocyclic lactones in Haemonchus contortus, and drug screening with Trichostrongylidae parasites. Vet Parasitol. 2006;137:294-305 pubmed
    ..system in 96-well plate format which is able to detect resistance to the macrocyclic lactone group of drugs in Haemonchus contortus...
  67. Ghisi M, Kaminsky R, Maser P. Phenotyping and genotyping of Haemonchus contortus isolates reveals a new putative candidate mutation for benzimidazole resistance in nematodes. Vet Parasitol. 2007;144:313-20 pubmed
    In order to monitor and eventually control the spread of drug-resistant Haemonchus contortus, knowledge of the molecular mechanisms underlying resistance is essential...
  68. O Connor L, Kahn L, Walkden Brown S. Moisture requirements for the free-living development of Haemonchus contortus: quantitative and temporal effects under conditions of low evaporation. Vet Parasitol. 2007;150:128-38 pubmed
    The key influence of moisture availability on development of the free-living stages of Haemonchus contortus is well-documented, although quantitative relationships between moisture variables and development are poorly defined...
  69. Gillan V, Maitland K, McCormack G, Him N, Devaney E. Functional genomics of hsp-90 in parasitic and free-living nematodes. Int J Parasitol. 2009;39:1071-81 pubmed publisher
    ..three nematodes, the free-living Caenorhabditis elegans (Ce) and the parasitic worms Brugia pahangi (Bp) and Haemonchus contortus (Hc). These molecules were functionally characterised by rescue of a Ce-daf-21 (hsp-90) null mutant...
  70. Rao V, Siddiqui S, Prichard R, Forrester S. A dopamine-gated ion channel (HcGGR3*) from Haemonchus contortus is expressed in the cervical papillae and is associated with macrocyclic lactone resistance. Mol Biochem Parasitol. 2009;166:54-61 pubmed publisher
    b>Haemonchus contortus, a parasitic nematode of great economic importance, is a major challenge for the livestock industries. The parasite is controlled by nematocidal drugs, several of which target ligand-gated chloride channels (LGCCs)...
  71. Saddiqi H, Iqbal Z, Khan M, Sarwar M, Muhammad G, Yaseen M, et al. Evaluation of three Pakistani sheep breeds for their natural resistance to artificial infection of Haemonchus contortus. Vet Parasitol. 2010;168:141-5 pubmed publisher
    ..Pakistani sheep breeds (Kachhi, Lohi and Thalli) for their natural resistance against artificial infection of Haemonchus contortus...
  72. Castillo J, Medina R, Villalobos J, Gayosso Vázquez A, Ulloa Arvízu R, Rodríguez R, et al. Association between major histocompatibility complex microsatellites, fecal egg count, blood packed cell volume and blood eosinophilia in Pelibuey sheep infected with Haemonchus contortus. Vet Parasitol. 2011;177:339-44 pubmed publisher
    ..of this study was to assess the correlation among traits associated with resistance or susceptibility to Haemonchus contortus infestation and to evaluate the participation of the ovine major histocompatibility complex (MHC) in ..
  73. Williamson S, Wolstenholme A. P-glycoproteins of Haemonchus contortus: development of real-time PCR assays for gene expression studies. J Helminthol. 2012;86:202-8 pubmed publisher
    ..We identified several sequences from the genome of the parasite Haemonchus contortus with convincing homology to the known P-gp coding genes of the model nematode Caenorhabditis elegans...
  74. Vokřál I, Jedličková V, Jirásko R, Stuchlíková L, Bártíková H, Skalova L, et al. The metabolic fate of ivermectin in host (Ovis aries) and parasite (Haemonchus contortus). Parasitology. 2013;140:361-7 pubmed publisher
    ..of our work was (1) to find and identify phase I and II metabolites of IVE formed by the Barber's pole worm (Haemonchus contortus), and (2) to compare IVE metabolites in helminths with IVE biotransformation in sheep (Ovis aries) as ..
  75. Zhu L, Dai J, Yang L, Qiu J. Anthelmintic activity of Arisaema franchetianum and Arisaema lobatum essential oils against Haemonchus contortus. J Ethnopharmacol. 2013;148:311-6 pubmed publisher
    ..The aim of this study was to determine the composition of the essential oils from Arisaema franchetianum and Arisaema lobatum and evaluate the anthelmintic effect against Haemonchus contortus.
  76. O Connor L, Kahn L, Walkden Brown S. The effects of amount, timing and distribution of simulated rainfall on the development of Haemonchus contortus to the infective larval stage. Vet Parasitol. 2007;146:90-101 pubmed
    ..determine the effects of amount, timing and distribution of simulated rainfall on the developmental success of Haemonchus contortus. Faeces containing H...
  77. Yanming S, Ruofeng Y, Muleke C, Guangwei Z, Lixin X, Xiangrui L. Vaccination of goats with recombinant galectin antigen induces partial protection against Haemonchus contortus infection. Parasite Immunol. 2007;29:319-26 pubmed
    The efficacy of vaccination against Haemonchus contortus infection with two recombinant proteins, rHco-gal-m and rHco-gal-f, was studied in 9-10-month-old goats...
  78. Nagaraj S, Deshpande N, Gasser R, Ranganathan S. ESTExplorer: an expressed sequence tag (EST) assembly and annotation platform. Nucleic Acids Res. 2007;35:W143-7 pubmed
    ..ESTExplorer runs on a Linux cluster and is freely available for the academic community at http://estexplorer.biolinfo.org...
  79. Andronicos N, Hunt P, Windon R. Expression of genes in gastrointestinal and lymphatic tissues during parasite infection in sheep genetically resistant or susceptible to Trichostrongylus colubriformis and Haemonchus contortus. Int J Parasitol. 2010;40:417-29 pubmed publisher
    ..produced lambs genetically resistant or susceptible to GIN, were acutely challenged once or thrice with either Haemonchus contortus or Trichostrongylus colubriformis. Faecal-egg counts (FECs), and plasma and tissue anti-parasite (H...
  80. Chiejina S, Behnke J, Musongong G, Nnadi P, Ngongeh L. Resistance and resilience of West African Dwarf goats of the Nigerian savanna zone exposed to experimental escalating primary and challenge infections with Haemonchus contortus. Vet Parasitol. 2010;171:81-90 pubmed publisher
    We assessed the resilience and resistance to infection with Haemonchus contortus of savanna West African Dwarf (WAD) goats from northern Nigeria...
  81. Campbell B, Tarleton M, Gordon C, Sakoff J, Gilbert J, McCluskey A, et al. Norcantharidin analogues with nematocidal activity in Haemonchus contortus. Bioorg Med Chem Lett. 2011;21:3277-81 pubmed publisher
    ..the design of a series of norcantharidin analogues (n=54) for activity testing against the barber's pole worm (Haemonchus contortus) of small ruminants in a larval development assay (LDA) and also for toxicity testing on nine distinct ..
  82. de la Chevrotière C, Bambou J, Arquet R, Jacquiet P, Mandonnet N. Genetic analysis of the potential role of IgA and IgE responses against Haemonchus contortus in parasite resistance of Creole goats. Vet Parasitol. 2012;186:337-43 pubmed publisher
    ..The aim of this study was thus to investigate genetic parameters of IgA and IgE responses against Haemonchus contortus in Creole kids naturally challenged at pasture and to determine the relationship with other resistance ..
  83. Juhnke J, Miller J, Hall J, Provenza F, Villalba J. Preference for condensed tannins by sheep in response to challenge infection with Haemonchus contortus. Vet Parasitol. 2012;188:104-14 pubmed publisher
    ..Subsequently, all animals were dosed with 10,000 L(3) stage larvae of Haemonchus contortus...
  84. Ejlertsen M, Githigia S, Otieno R, Thamsborg S. Accuracy of an anaemia scoring chart applied on goats in sub-humid Kenya and its potential for control of Haemonchus contortus infections. Vet Parasitol. 2006;141:291-301 pubmed
    We tested the practical application of an anaemia scoring chart (the FAMACHA chart) as a method for controlling Haemonchus contortus in goats kept under smallholder conditions in a sub-humid area of Central Kenya...
  85. Nikolaou S, Gasser R. Extending from PARs in Caenorhabditis elegans to homologues in Haemonchus contortus and other parasitic nematodes. Parasitology. 2007;134:461-82 pubmed
    ..in the knowledge and understanding of PAR-1 homologues from the economically important parasitic nematode, Haemonchus contortus, of small ruminants is summarized and discussed in the context of exploring avenues for future ..
  86. Eguale T, Tilahun G, Debella A, Feleke A, Makonnen E. In vitro and in vivo anthelmintic activity of crude extracts of Coriandrum sativum against Haemonchus contortus. J Ethnopharmacol. 2007;110:428-33 pubmed
    ..extracts of the seeds of Coriandrum sativum (Apiaceae) were investigated on the egg and adult nematode parasite Haemonchus contortus...
  87. Alba Hurtado F, Romero Escobedo E, Muñoz Guzmán M, Torres Hernández G, Becerril Pérez C. Comparison of parasitological and productive traits of Criollo lambs native to the central Mexican Plateau and Suffolk lambs experimentally infected with Haemonchus contortus. Vet Parasitol. 2010;172:277-82 pubmed publisher
    ..Criollo lambs native to the central Mexican Plateau (CNCMP) and Suffolk (SU) lambs experimentally infected with Haemonchus contortus. CNCMP lambs (n=20) and SU lambs (n=15) were infected with L3 of H...
  88. Buttle D, Behnke J, Bartley Y, Elsheikha H, Bartley D, Garnett M, et al. Oral dosing with papaya latex is an effective anthelmintic treatment for sheep infected with Haemonchus contortus. Parasit Vectors. 2011;4:36 pubmed publisher
    ..The cysteine proteinases in papaya latex have been shown to have potent anthelmintic properties in monogastric hosts such as rodents, pigs and humans, but this has not been demonstrated in ruminants...
  89. Boulin T, Fauvin A, Charvet C, Cortet J, Cabaret J, Bessereau J, et al. Functional reconstitution of Haemonchus contortus acetylcholine receptors in Xenopus oocytes provides mechanistic insights into levamisole resistance. Br J Pharmacol. 2011;164:1421-32 pubmed publisher
    ..been compromised by the emergence of drug-resistant parasites, especially in gastrointestinal nematodes such as Haemonchus contortus. We report here the first functional reconstitution and pharmacological characterization of H...
  90. Heckendorn F, Häring D, Maurer V, Zinsstag J, Langhans W, Hertzberg H. Effect of sainfoin (Onobrychis viciifolia) silage and hay on established populations of Haemonchus contortus and Cooperia curticei in lambs. Vet Parasitol. 2006;142:293-300 pubmed
    ..was to examine the effect of dried and ensiled sainfoin (Onobrychis viciifolia) on established populations of Haemonchus contortus (abomasum) and Cooperia curticei (small intestine) in lambs under controlled conditions...
  91. García Coiradas L, Angulo Cubillán F, Mendez S, Larraga V, de la Fuente C, Cuquerella M, et al. Isolation and immunolocalization of a putative protective antigen (p26/23) from adult Haemonchus contortus. Parasitol Res. 2009;104:363-9 pubmed publisher
    The putative protective antigen, p26/23, from adult Haemonchus contortus was isolated...
  92. Bambou J, de la Chevrotière C, Varo H, Arquet R, Kooyman F, Mandonnet N. Serum antibody responses in Creole kids experimentally infected with Haemonchus contortus. Vet Parasitol. 2008;158:311-8 pubmed publisher
    ..After drenching the animals were maintained worm-free during 1 month until experimental infection with 10,000 Haemonchus contortus infective larvae (L3)...